$116+ Cheap flights from South Carolina to Chicago (CHI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/19. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — CHI
Oct 24 — Oct 311
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from South Carolina to Chicago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Chicago
Cheapest
Best
Last-minute
One-way
Cheapest flights from South Carolina to ChicagoExplore the most affordable flight options available from South Carolina to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
Explore the most affordable flight options available from South Carolina to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/134:03 pm -
1 stop24h 27m
Tue 10/208:04 am -
1 stop24h 09m
Deal found 9/20![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/142:42 pm -
1 stop25h 48m
Wed 10/218:04 am -
2 stops27h 10m
Deal found 9/19![Multiple Airlines logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/33:00 pm -
2 stops22h 51m
Sat 11/78:00 am -
1 stop10h 12m
Deal found 9/22![Multiple Airlines logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/112:42 pm -
1 stop25h 55m
Mon 11/168:00 am -
1 stop24h 55m
Deal found 9/19![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1511:59 am -
1 stop28h 31m
Mon 10/198:04 am -
1 stop24h 51m
Deal found 9/22![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/142:42 pm -
1 stop25h 48m
Tue 10/208:04 am -
1 stop24h 09m
Deal found 9/23![Multiple Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
2 stops13h 16m
Sat 11/148:00 am -
1 stop10h 12m
Deal found 9/22![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:36 am -
1 stop14h 07m
Mon 11/98:00 am -
1 stop24h 55m
Deal found 9/20![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/310:15 pm -
1 stop16h 41m
Mon 12/76:10 am -
1 stop13h 51m
Deal found 9/19![Multiple Airlines logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
2 stops34h 30m
Mon 10/268:04 am -
1 stop11h 57m
Deal found 9/22![Multiple Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:49 pm -
1 stop25h 48m
Fri 11/68:00 am -
2 stops11h 12m
Deal found 9/22![Multiple Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/273:00 pm -
2 stops22h 51m
Sat 10/318:00 am -
1 stop10h 12m
Deal found 9/23![Multiple Airlines logo]()
$284
Best flights from South Carolina to ChicagoDiscover carefully curated flight deals from South Carolina to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
Discover carefully curated flight deals from South Carolina to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/48:00 am -
Nonstop2h 15m
Mon 11/912:45 pm -
Nonstop2h 05m
Deal found 9/23![Southwest logo]()
$317
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:20 am -
Nonstop2h 09m
Sun 10/186:55 am -
Nonstop2h 03m
Deal found 9/20![United Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/142:28 pm -
1 stop5h 37m
Mon 11/1611:35 am -
1 stop3h 54m
Deal found 9/22![Delta logo]()
$337
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:47 pm -
1 stop7h 12m
Fri 11/279:00 am -
1 stop4h 18m
Deal found 9/20![American Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:46 pm -
Nonstop2h 19m
Sun 10/256:29 am -
Nonstop2h 01m
Deal found 9/21![United Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:15 am -
2 stops8h 45m
Tue 10/271:30 pm -
Nonstop2h 10m
Deal found 9/23![Southwest logo]()
$332
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1112:25 pm -
1 stop4h 45m
Sat 11/149:00 am -
1 stop5h 47m
Deal found 9/21![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:04 pm -
1 stop5h 50m
Sun 11/226:00 am -
1 stop4h 08m
Deal found 9/20![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/226:30 am -
Nonstop2h 23m
Tue 12/296:35 am -
Nonstop1h 58m
Deal found 9/21![United Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:00 am -
Nonstop2h 15m
Fri 12/41:25 pm -
Nonstop2h 05m
Deal found 9/22![Southwest logo]()
$333
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:08 pm -
1 stop5h 52m
Mon 10/2612:05 pm -
1 stop4h 33m
Deal found 9/23![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:55 pm -
1 stop3h 59m
Mon 11/166:00 am -
1 stop4h 08m
Deal found 9/22![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/92:52 pm -
1 stop4h 59m
Thu 11/127:47 am -
Nonstop2h 34m
Deal found 9/22![United Airlines logo]()
$327
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2010:55 am -
1 stop6h 20m
Sat 10/245:00 am -
1 stop5h 05m
Deal found 9/23![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:28 am -
1 stop5h 46m
Mon 11/26:04 am -
1 stop6h 10m
Deal found 9/19![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:40 pm -
1 stop4h 15m
Sat 10/176:45 am -
1 stop4h 25m
Deal found 9/19![Southwest logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:51 pm -
1 stop4h 50m
Sun 10/186:55 am -
Nonstop2h 03m
Deal found 9/20![United Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:59 pm -
1 stop5h 34m
Tue 10/276:04 am -
1 stop3h 39m
Deal found 9/22![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:20 pm -
1 stop3h 55m
Sat 10/319:10 am -
1 stop6h 15m
Deal found 9/19![Southwest logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:00 pm -
Nonstop2h 40m
Mon 11/92:32 pm -
Nonstop2h 34m
Deal found 9/23![United Airlines logo]()
$333
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:11 pm -
1 stop6h 22m
Sat 10/244:19 pm -
1 stop6h 28m
Deal found 9/22![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:55 pm -
1 stop4h 15m
Thu 11/1212:45 pm -
2 stops7h 15m
Deal found 9/23![Southwest logo]()
$342
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:00 pm -
Nonstop2h 36m
Sat 12/1210:38 am -
Nonstop2h 22m
Deal found 9/23![United Airlines logo]()
$333
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:55 am -
1 stop6h 20m
Thu 10/296:29 am -
1 stop6h 57m
Deal found 9/22![American Airlines logo]()
$409
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:59 pm -
1 stop6h 12m
Wed 10/288:05 am -
1 stop6h 03m
Deal found 9/19![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:20 pm -
1 stop3h 55m
Fri 10/308:35 am -
1 stop10h 25m
Deal found 9/21![Southwest logo]()
$344
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:19 pm -
1 stop5h 38m
Sun 10/255:27 am -
1 stop4h 16m
Deal found 9/20![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/61:00 pm -
Nonstop2h 40m
Fri 1/88:40 am -
1 stop4h 33m
Deal found 9/19![United Airlines logo]()
$343
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:40 pm -
1 stop4h 15m
Sat 10/2410:25 am -
2 stops5h 35m
Deal found 9/23![Southwest logo]()
$344
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/34:17 pm -
1 stop7h 13m
Tue 11/106:41 am -
1 stop4h 12m
Deal found 9/19![American Airlines logo]()
$426
Last-minute flights from South Carolina to ChicagoDiscover last-minute flight deals from South Carolina to Chicago. Data last updated September 24, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Chicago. Data last updated September 24, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/64:03 pm -
1 stop24h 17m
Wed 10/148:30 am -
2 stops31h 55m
Deal found 9/19![Multiple Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/134:03 pm -
1 stop24h 27m
Tue 10/208:04 am -
1 stop24h 09m
Deal found 9/20![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/142:42 pm -
1 stop25h 48m
Wed 10/218:04 am -
2 stops27h 10m
Deal found 9/19![Multiple Airlines logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/142:42 pm -
1 stop25h 48m
Tue 10/208:04 am -
1 stop24h 09m
Deal found 9/23![Multiple Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1511:59 am -
1 stop28h 31m
Mon 10/198:04 am -
1 stop24h 51m
Deal found 9/22![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1510:13 pm -
1 stop18h 17m
Mon 10/198:04 am -
1 stop11h 57m
Deal found 9/23![Multiple Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:57 pm -
1 stop23h 33m
Mon 10/2610:26 am -
2 stops21h 12m
Deal found 9/21![Multiple Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
2 stops34h 30m
Mon 10/268:04 am -
1 stop11h 57m
Deal found 9/22![Multiple Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:08 pm -
1 stop22h 22m
Thu 10/298:00 am -
1 stop23h 51m
Deal found 9/22![Multiple Airlines logo]()
$288
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/273:00 pm -
2 stops22h 51m
Sat 10/318:00 am -
1 stop10h 12m
Deal found 9/23![Multiple Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:49 pm -
1 stop25h 48m
Fri 11/68:00 am -
2 stops11h 12m
Deal found 9/22![Multiple Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:53 pm -
1 stop26h 44m
Tue 11/37:15 am -
2 stops24h 58m
Deal found 9/23![Multiple Airlines logo]()
$299
One-way flights from South Carolina to ChicagoSearch for one-way flight options from South Carolina to Chicago. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
Search for one-way flight options from South Carolina to Chicago. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:08 pm -
2 stops21h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/204:03 pm -
1 stop24h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/244:03 pm -
1 stop21h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/248:58 am -
1 stop28h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/168:09 pm -
1 stop17h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:52 pm -
1 stop20h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2011:28 am -
2 stops29h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:21 pm -
2 stops27h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1510:13 pm -
1 stop18h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/199:36 am -
1 stop14h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Frontier logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/232:49 pm -
1 stop22h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/208:43 am -
1 stop29h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Multiple Airlines logo]()
$132
Find flight deals from South Carolina to Chicago
Keep the following information in mind while searching for South Carolina to Chicago flight deals. Data was last updated September 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $241 (Kiwi.com) |
One-way from | $116 (Kiwi.com) |
Popular in | July |
Cheapest in | January |
Average price | $329 |
Good round-trip deal | $369 or less |
Good one-way deal | $195 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
Use the filters below to find and compare flights from South Carolina to Chicago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
CharlestonChicago
CHS Charleston - MDW Chicago Midway
CHSMDW
Charleston
Wed 10/21
7:15 am-8:25 am
Nonstop2h 10m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$159
CharlestonChicago
CHS Charleston - ORD Chicago O'Hare Intl
CHSORD
Charleston
Thu 10/22
6:50 pm-11:30 pm
1 stop5h 40m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$159
CharlestonChicago
CHS Charleston - ORD Chicago O'Hare Intl
CHSORD
Charleston
Mon 10/19
6:30 am-8:00 am
Nonstop2h 30m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$159
CharlestonChicago
CHS Charleston - ORD Chicago O'Hare Intl
CHSORD
Charleston
Sat 10/10
6:50 pm-11:30 pm
1 stop5h 40m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$159
CharlestonChicago
CHS Charleston - ORD Chicago O'Hare Intl
CHSORD
Charleston
Mon 10/26
6:56 pm-11:57 pm
1 stop6h 01m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$159
GreenvilleChicago
GSP Greenville - ORD Chicago O'Hare Intl
GSPORD
Greenville
Wed 10/28
5:37 pm-6:59 pm
Nonstop2h 22m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$160
CharlestonChicago
CHS Charleston - MDW Chicago Midway
CHSMDW
Charleston
Wed 10/21
6:30 am-10:03 am
1 stop4h 33m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$169
CharlestonChicago
CHS Charleston - MDW Chicago Midway
CHSMDW
Charleston
Mon 11/16
7:04 pm-10:54 pm
1 stop4h 50m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$169
CharlestonChicago
CHS Charleston - MDW Chicago Midway
CHSMDW
Charleston
Thu 10/22
4:45 pm-10:00 pm
1 stop6h 15m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$169
CharlestonChicago
CHS Charleston - MDW Chicago Midway
CHSMDW
Charleston
Tue 10/20
5:43 pm-10:33 pm
1 stop5h 50m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$169
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Chicago
Have a flexible travel schedule? Discover the best time to fly to Chicago from South Carolina with our price prediction graph.
MYR-ORD
CHS-ORD
GSP-ORD
CHS-MDW
GSP-MDW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Chicago
USSC-CHI
MYR-ORD
CHS-ORD
GSP-ORD
CHS-MDW
What is the cheapest month to book a flight from South Carolina to Chicago?
Currently, January is the cheapest month in which you can book a flight from South Carolina to Chicago (average of $310). Flying from South Carolina to Chicago in June is currently the most expensive (average of $389). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to CHI?
Find hourly flight availability from South Carolina to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 24, 2026.
When flying from South Carolina to Chicago, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 34% versus a flight at noon.
Weekly flight availability from South Carolina to Chicago
Explore weekly flight availability from South Carolina to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 24, 2026.
The most flights from USSC to CHI are scheduled on a Monday (22 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (5 on average).
How much does it cost to fly round-trip from South Carolina to Chicago?
Airfare is below average for this route at the moment.
South Carolina to Chicago flights typically cost between $272 and $460 in November.The cheapest round-trip price found within the last 5 days was $268 on Multiple Airlines (Nov 3-Nov 7).
How far ahead should I book a flight from South Carolina to Chicago?
Booking 83 days in advance of your planned departure date is, on average, the best time to get cheap flights from South Carolina to Chicago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest day to fly from South Carolina to Chicago?
Use this chart to determine the cheapest time to fly round-trip from South Carolina to Chicago. Price data was last updated on September 19, 2026.
Travelers seeking maximum savings on their South Carolina to Chicago flight should consider departing on Friday at noon when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Chicago?
Book flights to Chicago if you plan to visit one of these locationsBenton Harbor
Lansing
Merrillville
Valparaiso
Hammond
Saint Joseph
Porter
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Chicago flight routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for South Carolina to Chicago
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Chicago
Explore flights to Chicago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 24, 2026.
Complete your trip
Complete your trip to Chicago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Chicago by cabin class
Find flights from South Carolina to Chicago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Chicago flights
Browse other South Carolina and Chicago flight options. Last updated on September 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Chicago flights
Consider these flights traveling from South Carolina to Chicago.
Top 4 airlines flying from South Carolina to Chicago
Discover the top 4 airlines that operate flights from South Carolina to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$156 | Average$316 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$202 | Average$388 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$209 | Average$354 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$258 | Average$370 | FlexibilityNo cancel fee | On-time63% |