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$81+ Cheap flights from South Carolina to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/2. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — CHI
Jun 11 — Jun 181
Thu 6/11
Thu 6/18
1 adult, Economy
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Cheap flight deals from South Carolina to Chicago

Cheapest flights from South Carolina to Chicago
Explore the most affordable flight options available from South Carolina to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 12, 2026.

This Expedia deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/910:01 am
CLT
-
ORD
1 stop15h 47m
Frontier
Tue 6/164:59 pm
ORD
-
CLT
1 stop22h 54m
Frontier
Deal found 5/10$190
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:05 am
SAV
-
ORD
1 stop27h 20m
Multiple Airlines
Wed 9/27:55 am
ORD
-
SAV
1 stop6h 56m
Multiple Airlines
Deal found 5/7$192
This Kiwi.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/910:01 am
CLT
-
ORD
1 stop15h 47m
Frontier
Wed 6/175:29 pm
ORD
-
CLT
1 stop18h 08m
Frontier
Deal found 5/10$203
This Frontier deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:57 pm
CLT
-
ORD
1 stop7h 52m
Frontier
Sat 7/188:05 pm
ORD
-
CLT
1 stop11h 34m
Frontier
Deal found 5/12$204
This Frontier deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:57 pm
CLT
-
ORD
1 stop7h 52m
Frontier
Thu 8/69:34 pm
ORD
-
CLT
1 stop12h 42m
Frontier
Deal found 5/10$210
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/155:57 pm
CLT
-
ORD
1 stop7h 52m
Frontier
Sat 7/188:05 pm
ORD
-
CLT
1 stop11h 34m
Frontier
Deal found 5/7$211
This Kiwi.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:57 pm
CLT
-
ORD
1 stop7h 52m
Frontier
Thu 7/1612:44 am
ORD
-
CLT
1 stop11h 08m
Frontier
Deal found 5/10$212
This CheapOair deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:59 pm
CLT
-
ORD
1 stop7h 43m
Frontier
Mon 8/249:48 pm
ORD
-
CLT
1 stop19h 31m
Frontier
Deal found 5/11$214
This Mytrip deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:05 pm
CLT
-
ORD
1 stop17h 35m
Contour
Mon 6/111:20 am
ORD
-
CLT
1 stop4h 40m
Contour
Deal found 5/7$215
This Gotogate deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/910:01 am
CLT
-
ORD
1 stop15h 47m
Multiple Airlines
Thu 6/1111:20 am
ORD
-
CLT
1 stop4h 40m
Multiple Airlines
Deal found 5/11$216
This Kiwi.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:59 pm
CLT
-
ORD
1 stop7h 49m
Frontier
Tue 6/164:59 pm
ORD
-
CLT
1 stop17h 35m
Frontier
Deal found 5/10$217
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1012:22 pm
MYR
-
ORD
Nonstop2h 32m
American Airlines
Tue 6/168:30 am
ORD
-
MYR
Nonstop2h 23m
American Airlines
Deal found 5/12$217

Find flight deals from South Carolina to Chicago

Keep the following information in mind while searching for South Carolina to Chicago flight deals. Data was last updated May 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$190
(Expedia)

One-way from

$81
(Kiwi.com)

Popular in

November

Cheapest in

August

Average price

$331

Good round-trip deal

$309 or less

Good one-way deal

$180 or less
Provider with most accurate pricing for Myrtle Beach Intl-Chicago (CHI) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Chicago (CHI) flights.
Search Deals
From South Carolina to Chicago (CHI)
Search Deals
One-way flight from South Carolina to Chicago (CHI)
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($60 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals
Price to beat on a round-trip flight from South Carolina to Chicago (CHI).
Search Deals
Price to beat on a one-way flight from South Carolina to Chicago (CHI).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 12, 2026.
Use the filters below to find and compare flights from South Carolina to Chicago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachChicago

MYR - ORD

MYRORD

Myrtle Beach Intl

Wed 6/10

7:57 pm-11:59 pm

1 stop5h 02m

Chicago O'Hare Intl

Tue 6/16

1:46 pm-7:07 pm

1 stop4h 21m

$237

Myrtle BeachChicago

MYR - ORD

MYRORD

Myrtle Beach Intl

Tue 6/23

4:17 pm-8:32 pm

1 stop5h 15m

Chicago O'Hare Intl

Tue 7/28

5:30 am-10:47 am

1 stop4h 17m

$247

SavannahChicago

SAV - ORD

SAVORD

Savannah/Hilton Head

Wed 6/17

8:00 am-9:39 am

Nonstop2h 39m

Chicago O'Hare Intl

Tue 6/23

6:20 pm-9:56 pm

Nonstop2h 36m

$257

GreenvilleChicago

GSP - ORD

GSPORD

Greenville

Fri 5/29

5:41 pm-6:58 pm

Nonstop2h 17m

Chicago O'Hare Intl

Mon 6/1

6:55 am-9:55 am

Nonstop2h 00m

$262

Myrtle BeachChicago

MYR - ORD

MYRORD

Myrtle Beach Intl

Thu 5/28

6:30 pm-8:04 pm

Nonstop2h 34m

Chicago O'Hare Intl

Wed 6/10

7:03 am-10:36 am

Nonstop2h 33m

$266

SavannahChicago

SAV - ORD

SAVORD

Savannah/Hilton Head

Wed 6/3

7:15 pm-11:26 pm

1 stop5h 11m

Chicago O'Hare Intl

Tue 6/9

6:20 pm-9:56 pm

Nonstop2h 36m

$267

ColumbiaChicago

CAE - ORD

CAEORD

Columbia Metropolitan

Tue 6/9

6:25 am-7:52 am

Nonstop2h 27m

Chicago O'Hare Intl

Thu 6/25

5:55 pm-9:16 pm

Nonstop2h 21m

$269

GreenvilleChicago

GSP - ORD

GSPORD

Greenville

Mon 6/8

5:43 pm-7:00 pm

Nonstop2h 17m

Chicago O'Hare Intl

Mon 6/15

6:10 pm-9:17 pm

Nonstop2h 07m

$269

GreenvilleChicago

GSP - ORD

GSPORD

Greenville

Wed 6/3

5:43 pm-7:00 pm

Nonstop2h 17m

Chicago O'Hare Intl

Sat 6/6

6:55 am-9:55 am

Nonstop2h 00m

$269

GreenvilleChicago

GSP - ORD

GSPORD

Greenville

Thu 9/17

6:30 am-7:37 am

Nonstop2h 07m

Chicago O'Hare Intl

Mon 9/21

6:40 am-9:43 am

Nonstop2h 03m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/9

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from South Carolina to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Chicago

How far ahead should I book a flight from South Carolina to Chicago?

Booking 76 days in advance of your planned departure date is, on average, the best time to get cheap flights from South Carolina to Chicago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from South Carolina to Chicago?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Chicago (average of $47). Flying from South Carolina to Chicago in February is currently the most expensive (average of $181). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to CHI?

Find hourly flight availability from South Carolina to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 12, 2026.

When flying from South Carolina to Chicago, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 32% versus a flight at noon.

What is the cheapest day to fly from South Carolina to Chicago?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Chicago. Price data was last updated on May 9, 2026.

Travelers seeking maximum savings on their South Carolina to Chicago flight should consider departing on Friday at noon when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from South Carolina to Chicago

Explore weekly flight availability from South Carolina to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated May 12, 2026.

The most flights from USSC to CHI are scheduled on a Monday (31 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (18 on average).

How much does it cost to fly round-trip from South Carolina to Chicago?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Chicago?

    Delta, United Airlines, and Southwest can get you from South Carolina to Chicago in just under 2h 10m. Your travel time can differ by up to 2h 52m. Airlines will cover a distance of 745 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Chicago one-way?

    $60 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Southwest and American Airlines, with prices starting from $78 and $99, respectively.

  • What are the most popular routes from South Carolina to Chicago?

    While some choose either Greenville - Chicago O'Hare Intl or Columbia Metropolitan - Chicago O'Hare Intl, Charlotte Douglas - Chicago O'Hare Intl is the most popular route from South Carolina to Chicago.

  • What are the most reliable airlines from South Carolina to Chicago?

    Consider Envoy Air (87%), Qatar Airways (80%) or American Airlines (80%) when booking your flight. These represent the most reliable airlines when flying from South Carolina to Chicago.

  • What are the cheapest flights from South Carolina to Chicago?

    The cheapest flight price from South Carolina to Chicago is $132. On average you can expect to pay $899. The most popular route, (Charlotte Douglas - Chicago O'Hare Intl), can usually be booked for $222.

  • Can I find deals for flights from South Carolina to Chicago that include hotel bookings?

    Yes. In addition to deals on South Carolina to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Chicago.

  • Can I find deals for business class flights from South Carolina to Chicago?

    Yes. Cheapflights offers flight deals from South Carolina to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Chicago?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Chicago (average of $47). Flying from South Carolina to Chicago in February is currently the most expensive (average of $181). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Benton Harbor
Lansing
Merrillville
Hammond
Porter

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Alternative routes for South Carolina to Chicago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from South Carolina to Chicago

Discover the top 5 airlines that operate flights from South Carolina to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$60Average$182FlexibilityNo cancel feeOn-time65%
DeltaCheapest$107Average$376FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$135Average$350FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$178Average$356FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$190Average$362FlexibilityNo cancel feeOn-time63%

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