$81+ Cheap flights from South Carolina to Chicago (CHI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/18. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — CHI
Dec 12 — Dec 191
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Chicago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Chicago
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Cheapest flights from South Carolina to ChicagoExplore the most affordable flight options available from South Carolina to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2026.
Explore the most affordable flight options available from South Carolina to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/92:57 pm -
1 stop24h 03m
Mon 12/148:59 am -
2 stops23h 56m
Deal found 11/9![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/112:49 pm -
1 stop9h 03m
Sun 12/133:30 pm -
1 stop15h 09m
Deal found 11/9![Multiple Airlines logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:09 pm -
1 stop21h 50m
Wed 12/308:59 am -
1 stop9h 30m
Deal found 11/11![Multiple Airlines logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/98:09 pm -
1 stop18h 51m
Mon 12/147:59 am -
1 stop27h 32m
Deal found 11/9![Multiple Airlines logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:10 pm -
1 stop18h 50m
Mon 12/76:07 am -
1 stop26h 48m
Deal found 11/10![Multiple Airlines logo]()
$323
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:52 pm -
2 stops27h 42m
Fri 11/274:00 pm -
1 stop14h 54m
Deal found 11/8![Multiple Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/182:42 pm -
1 stop27h 10m
Fri 12/255:01 am -
1 stop9h 46m
Deal found 11/7![Multiple Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/232:42 pm -
1 stop9h 52m
Fri 11/274:00 pm -
1 stop14h 54m
Deal found 11/9![Multiple Airlines logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/72:58 pm -
2 stops32h 02m
Mon 12/146:07 am -
1 stop7h 01m
Deal found 11/7![Multiple Airlines logo]()
$332
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/83:00 pm -
1 stop11h 08m
Tue 12/154:00 pm -
2 stops15h 38m
Deal found 11/7![Multiple Airlines logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/248:10 pm -
1 stop21h 49m
Tue 12/298:59 am -
1 stop23h 29m
Deal found 11/8![Multiple Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/104:02 pm -
2 stops30h 27m
Mon 1/117:10 am -
1 stop9h 16m
Deal found 11/10![Multiple Airlines logo]()
$334
Best flights from South Carolina to ChicagoDiscover carefully curated flight deals from South Carolina to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 12, 2026.
Discover carefully curated flight deals from South Carolina to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 12, 2026.
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:00 am -
Nonstop2h 33m
Sun 12/138:44 pm -
Nonstop2h 12m
Deal found 11/11![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/3110:43 am -
Nonstop2h 15m
Sun 1/36:35 am -
Nonstop1h 58m
Deal found 11/9![United Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:00 pm -
1 stop6h 00m
Wed 12/307:15 pm -
Nonstop2h 10m
Deal found 11/7![Southwest logo]()
$369
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/192:38 pm -
1 stop5h 10m
Mon 1/257:10 am -
1 stop5h 43m
Deal found 11/11![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:30 am -
Nonstop2h 16m
Sun 12/61:49 pm -
Nonstop2h 04m
Deal found 11/10![United Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/129:45 am -
1 stop6h 50m
Wed 12/161:25 pm -
Nonstop2h 05m
Deal found 11/7![Southwest logo]()
$369
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:05 pm -
1 stop4h 57m
Mon 12/215:21 am -
1 stop4h 17m
Deal found 11/8![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:26 am -
1 stop5h 51m
Tue 12/1510:36 am -
1 stop6h 27m
Deal found 11/8![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1212:10 pm -
Nonstop2h 42m
Wed 12/1610:38 am -
Nonstop2h 22m
Deal found 11/7![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/202:38 pm -
1 stop5h 10m
Wed 2/177:05 am -
1 stop5h 47m
Deal found 11/10![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/310:45 am -
2 stops8h 40m
Mon 12/78:00 am -
1 stop4h 15m
Deal found 11/10![Southwest logo]()
$374
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2411:08 am -
1 stop6h 11m
Thu 12/315:21 am -
1 stop4h 17m
Deal found 11/9![American Airlines logo]()
$376
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/125:45 pm -
Nonstop2h 20m
Sat 1/98:40 am -
1 stop4h 44m
Deal found 11/11![United Airlines logo]()
$368
This Delta deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/217:03 pm -
1 stop5h 59m
Thu 12/316:00 am -
1 stop4h 25m
Deal found 11/7![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/281:30 pm -
2 stops8h 35m
Mon 2/17:45 am -
1 stop4h 05m
Deal found 11/9![Southwest logo]()
$374
This Delta deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/105:35 am -
1 stop5h 53m
Thu 12/176:00 am -
1 stop4h 08m
Deal found 11/7![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/279:23 am -
Nonstop2h 06m
Tue 12/11:49 pm -
Nonstop2h 04m
Deal found 11/10![United Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/222:49 pm -
1 stop6h 14m
Thu 11/265:19 am -
1 stop4h 17m
Deal found 11/7![American Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/510:50 am -
1 stop5h 45m
Mon 12/711:30 am -
2 stops8h 20m
Deal found 11/10![Southwest logo]()
$374
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/115:30 am -
1 stop5h 35m
Mon 2/155:49 pm -
1 stop4h 57m
Deal found 11/10![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:47 pm -
1 stop5h 47m
Fri 11/2711:44 am -
1 stop4h 24m
Deal found 11/8![American Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/177:15 am -
2 stops8h 05m
Thu 2/183:40 pm -
1 stop5h 10m
Deal found 11/9![Southwest logo]()
$374
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/119:45 am -
Nonstop2h 39m
Thu 1/147:30 am -
Nonstop2h 38m
Deal found 11/8![United Airlines logo]()
$389
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/77:50 pm -
1 stop4h 04m
Mon 12/146:00 am -
1 stop4h 08m
Deal found 11/9![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:47 pm -
1 stop7h 12m
Sun 11/296:41 am -
1 stop6h 37m
Deal found 11/10![American Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/168:15 am -
2 stops9h 50m
Sat 1/237:55 am -
2 stops8h 55m
Deal found 11/11![Southwest logo]()
$379
This United Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:37 pm -
Nonstop2h 23m
Fri 11/278:50 am -
1 stop4h 27m
Deal found 11/7![United Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/55:20 am -
1 stop5h 40m
Wed 1/136:00 am -
1 stop4h 30m
Deal found 11/8![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:45 pm -
1 stop5h 00m
Fri 1/18:00 am -
1 stop5h 10m
Deal found 11/9![Southwest logo]()
$389
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/295:09 am -
1 stop6h 51m
Thu 12/316:50 am -
1 stop6h 20m
Deal found 11/8![American Airlines logo]()
$436
Last-minute flights from South Carolina to ChicagoDiscover last-minute flight deals from South Carolina to Chicago. Data last updated November 12, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Chicago. Data last updated November 12, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:52 pm -
2 stops27h 42m
Fri 11/274:00 pm -
1 stop14h 54m
Deal found 11/8![Multiple Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/232:42 pm -
1 stop9h 52m
Fri 11/274:00 pm -
1 stop14h 54m
Deal found 11/9![Multiple Airlines logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:10 pm -
1 stop18h 50m
Mon 12/76:07 am -
1 stop26h 48m
Deal found 11/10![Multiple Airlines logo]()
$323
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/72:58 pm -
2 stops32h 02m
Mon 12/146:07 am -
1 stop7h 01m
Deal found 11/7![Multiple Airlines logo]()
$332
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/83:00 pm -
1 stop11h 08m
Tue 12/154:00 pm -
2 stops15h 38m
Deal found 11/7![Multiple Airlines logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/92:57 pm -
1 stop24h 03m
Mon 12/148:59 am -
2 stops23h 56m
Deal found 11/9![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/98:09 pm -
1 stop18h 51m
Mon 12/147:59 am -
1 stop27h 32m
Deal found 11/9![Multiple Airlines logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/104:02 pm -
2 stops30h 27m
Mon 1/117:10 am -
1 stop9h 16m
Deal found 11/10![Multiple Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/112:49 pm -
1 stop9h 03m
Sun 12/133:30 pm -
1 stop15h 09m
Deal found 11/9![Multiple Airlines logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/182:42 pm -
1 stop27h 10m
Fri 12/255:01 am -
1 stop9h 46m
Deal found 11/7![Multiple Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:09 pm -
1 stop21h 50m
Wed 12/308:59 am -
1 stop9h 30m
Deal found 11/11![Multiple Airlines logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/248:10 pm -
1 stop21h 49m
Tue 12/298:59 am -
1 stop23h 29m
Deal found 11/8![Multiple Airlines logo]()
$334
One-way flights from South Carolina to ChicagoSearch for one-way flight options from South Carolina to Chicago. Find affordable one-way fares based on user searches. Data last updated November 12, 2026.
Search for one-way flight options from South Carolina to Chicago. Find affordable one-way fares based on user searches. Data last updated November 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/182:42 pm -
1 stop27h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/11![Multiple Airlines logo]()
$81
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/98:09 pm -
1 stop18h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/11![Multiple Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/151:21 pm -
2 stops26h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/11![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:13 pm -
1 stop26h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/10![Multiple Airlines logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/77:18 pm -
1 stop21h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:40 am -
2 stops16h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/11![Multiple Airlines logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/51:21 pm -
2 stops33h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/11![Multiple Airlines logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/116:12 pm -
2 stops31h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$132
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/78:52 pm -
3 stops15h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/11![Multiple Airlines logo]()
$132
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/72:42 pm -
2 stops32h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/193:07 pm -
2 stops33h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/78:58 pm -
2 stops18h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$136
Find flight deals from South Carolina to Chicago
Keep the following information in mind while searching for South Carolina to Chicago flight deals. Data was last updated November 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $304 (Kiwi.com) |
One-way from | $81 (Kiwi.com) |
Popular in | July |
Cheapest in | December |
Average price | $376 |
Good round-trip deal | $376 or less |
Good one-way deal | $188 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 12, 2026.
Use the filters below to find and compare flights from South Carolina to Chicago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachChicago
MYR Myrtle Beach Intl - ORD Chicago O'Hare Intl
MYRORD
Myrtle Beach Intl
Fri 12/11
6:12 pm-10:00 pm
2 stops28h 48m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$142
CharlestonChicago
CHS Charleston - ORD Chicago O'Hare Intl
CHSORD
Charleston
Thu 12/3
10:15 pm-2:00 pm
1 stop16h 45m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$148
Myrtle BeachChicago
MYR Myrtle Beach Intl - MDW Chicago Midway
MYRMDW
Myrtle Beach Intl
Fri 12/11
6:12 pm-11:33 am
3 stops18h 21m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$163
CharlestonChicago
CHS Charleston - ORD Chicago O'Hare Intl
CHSORD
Charleston
Tue 12/22
4:55 pm-6:37 pm
Nonstop2h 42m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$180
CharlestonChicago
CHS Charleston - ORD Chicago O'Hare Intl
CHSORD
Charleston
Tue 1/19
12:50 pm-2:33 pm
Nonstop2h 43m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$180
GreenvilleChicago
GSP Greenville - ORD Chicago O'Hare Intl
GSPORD
Greenville
Sat 12/12
5:34 pm-7:00 pm
Nonstop2h 26m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$180
Myrtle BeachChicago
MYR Myrtle Beach Intl - ORD Chicago O'Hare Intl
MYRORD
Myrtle Beach Intl
Thu 12/17
8:10 pm-4:59 pm
1 stop21h 49m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$181
Quickest round-trip
CharlestonChicago
CHS Charleston - MDW Chicago Midway
CHSMDW
Charleston
Tue 12/15
8:00 am-9:15 am
Nonstop2h 15m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$185
Myrtle BeachChicago
MYR Myrtle Beach Intl - ORD Chicago O'Hare Intl
MYRORD
Myrtle Beach Intl
Sat 12/12
10:52 am-5:06 pm
1 stop7h 14m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$185
CharlestonChicago
CHS Charleston - MDW Chicago Midway
CHSMDW
Charleston
Wed 12/16
8:00 am-9:15 am
Nonstop2h 15m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$185
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Chicago
Have a flexible travel schedule? Discover the best time to fly to Chicago from South Carolina with our price prediction graph.
MYR-ORD
CHS-ORD
CHS-MDW
MYR-MDW
GSP-ORD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Chicago
USSC-CHI
MYR-ORD
CHS-ORD
CHS-MDW
MYR-MDW
What is the cheapest month to book a flight from South Carolina to Chicago?
Currently, January is the cheapest month in which you can book a flight from South Carolina to Chicago (average of $327). Flying from South Carolina to Chicago in June is currently the most expensive (average of $390). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to CHI?
Find hourly flight availability from South Carolina to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 12, 2026.
When flying from South Carolina to Chicago, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 34% versus a flight at noon.
Weekly flight availability from South Carolina to Chicago
Explore weekly flight availability from South Carolina to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated November 12, 2026.
The most flights from USSC to CHI are scheduled on a Monday (25 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (11 on average).
How much does it cost to fly round-trip from South Carolina to Chicago?
Airfare is below average for this route at the moment.
South Carolina to Chicago flights typically cost between $338 and $497 in January.The cheapest round-trip price found within the last 5 days was $299 on Multiple Airlines (Jan 23-Jan 26).
How far ahead should I book a flight from South Carolina to Chicago?
Booking 66 days in advance of your planned departure date is, on average, the best time to get cheap flights from South Carolina to Chicago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest day to fly from South Carolina to Chicago?
Use this chart to determine the cheapest time to fly round-trip from South Carolina to Chicago. Price data was last updated on November 7, 2026.
Travelers seeking maximum savings on their South Carolina to Chicago flight should consider departing on Friday at noon when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Chicago?
Book flights to Chicago if you plan to visit one of these locationsBenton Harbor
Merrillville
Lansing
Valparaiso
Hammond
Saint Joseph
Porter
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Chicago flight routes
Complete your trip
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Alternative routes for South Carolina to Chicago
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Chicago
Explore flights to Chicago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 12, 2026.
Complete your trip
Complete your trip to Chicago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Chicago by cabin class
Find flights from South Carolina to Chicago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Chicago flights
Browse other South Carolina and Chicago flight options. Last updated on November 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Chicago flights
Consider these flights traveling from South Carolina to Chicago.
Top 4 airlines flying from South Carolina to Chicago
Discover the top 4 airlines that operate flights from South Carolina to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$156 | Average$314 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$209 | Average$359 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$218 | Average$398 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$258 | Average$370 | FlexibilityNo cancel fee | On-time63% |