$64+ Cheap flights from St. Louis (STL) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/7. Fares are subject to change and may not be available on all flights or dates of travel.
STL — RDU
Sep 6 — Sep 131
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from St. Louis to Durham with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Lambert-St Louis to Durham are usually found in October or February, booked 16 days in advance, depart on a Saturday or Wednesday and return on a Wednesday
Cheap flight deals from St. Louis to Durham
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to DurhamExplore the most affordable flight options available from St. Louis to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 7, 2026.
Explore the most affordable flight options available from St. Louis to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:29 pm -
1 stop9h 00m
Mon 9/146:35 am -
1 stop7h 35m
Deal found 8/3![Frontier logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:29 pm -
1 stop9h 00m
Mon 10/56:35 am -
1 stop7h 35m
Deal found 8/7![Frontier logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/252:29 pm -
1 stop9h 00m
Sun 9/271:56 pm -
1 stop24h 14m
Deal found 8/2![Frontier logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/182:29 pm -
1 stop9h 00m
Sun 9/201:56 pm -
1 stop24h 14m
Deal found 8/3![Frontier logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/46:17 pm -
1 stop14h 39m
Sun 9/66:05 am -
1 stop12h 17m
Deal found 8/5![Frontier logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:17 pm -
1 stop12h 19m
Tue 9/810:11 pm -
1 stop15h 59m
Deal found 8/3![Frontier logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/232:29 pm -
1 stop9h 00m
Mon 9/286:35 am -
1 stop7h 35m
Deal found 8/6![Frontier logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:17 pm -
1 stop13h 15m
Thu 9/36:05 am -
1 stop12h 17m
Deal found 8/4![Frontier logo]()
$142
Best flights from St. Louis to DurhamDiscover carefully curated flight deals from St. Louis to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 7, 2026.
Discover carefully curated flight deals from St. Louis to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 7, 2026.
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/273:39 pm -
1 stop6h 46m
Tue 9/159:50 am -
1 stop4h 16m
Deal found 8/2![Delta logo]()
$315
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:20 am -
Nonstop1h 50m
Mon 10/56:00 am -
Nonstop2h 10m
Deal found 8/4![Southwest logo]()
$315
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3112:27 pm -
1 stop5h 13m
Tue 9/16:00 am -
1 stop4h 39m
Deal found 8/3![United Airlines logo]()
$320
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:35 pm -
1 stop5h 53m
Tue 11/38:00 am -
1 stop6h 39m
Deal found 8/5![Delta logo]()
$325
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3112:55 pm -
1 stop6h 55m
Tue 9/16:55 pm -
Nonstop2h 05m
Deal found 8/6![Southwest logo]()
$325
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:30 am -
2 stops7h 30m
Wed 10/216:05 pm -
1 stop5h 10m
Deal found 8/7![Southwest logo]()
$340
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:00 am -
2 stops8h 07m
Tue 11/36:15 am -
1 stop5h 17m
Deal found 8/3![United Airlines logo]()
$390
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:50 pm -
1 stop4h 20m
Sun 10/46:10 am -
Nonstop2h 10m
Deal found 8/2![Southwest logo]()
$367
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:30 am -
2 stops7h 55m
Mon 8/316:30 pm -
1 stop4h 10m
Deal found 8/6![Southwest logo]()
$381
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:30 am -
2 stops8h 55m
Sun 10/2510:20 am -
2 stops7h 55m
Deal found 8/6![Southwest logo]()
$426
Last-minute flights from St. Louis to DurhamDiscover last-minute flight deals from St. Louis to Durham. Data last updated August 7, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Durham. Data last updated August 7, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:17 pm -
1 stop13h 15m
Thu 9/36:05 am -
1 stop12h 17m
Deal found 8/4![Frontier logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/46:17 pm -
1 stop14h 39m
Sun 9/66:05 am -
1 stop12h 17m
Deal found 8/5![Frontier logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:17 pm -
1 stop12h 19m
Tue 9/810:11 pm -
1 stop15h 59m
Deal found 8/3![Frontier logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:29 pm -
1 stop9h 00m
Mon 9/146:35 am -
1 stop7h 35m
Deal found 8/3![Frontier logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/182:29 pm -
1 stop9h 00m
Sun 9/201:56 pm -
1 stop24h 14m
Deal found 8/3![Frontier logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/232:29 pm -
1 stop9h 00m
Mon 9/286:35 am -
1 stop7h 35m
Deal found 8/6![Frontier logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/232:29 pm -
1 stop21h 09m
Sun 9/271:56 pm -
1 stop24h 14m
Deal found 8/3![Frontier logo]()
$146
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/252:29 pm -
1 stop9h 00m
Sun 9/271:56 pm -
1 stop24h 14m
Deal found 8/2![Frontier logo]()
$133
One-way flights from St. Louis to DurhamSearch for one-way flight options from St. Louis to Durham. Find affordable one-way fares based on user searches. Data last updated August 7, 2026.
Search for one-way flight options from St. Louis to Durham. Find affordable one-way fares based on user searches. Data last updated August 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:17 pm -
1 stop12h 19m
Deal found 8/6![Frontier logo]()
$64
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:17 pm -
1 stop13h 15m
Deal found 8/4![Frontier logo]()
$65
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/510:35 am -
1 stop12h 42m
Deal found 8/7![Frontier logo]()
$66
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:29 pm -
1 stop9h 00m
Deal found 8/3![Frontier logo]()
$68
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/810:35 am -
1 stop19h 55m
Deal found 8/7![Frontier logo]()
$69
This Trip.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/182:29 pm -
1 stop9h 00m
Deal found 8/5![Frontier logo]()
$71
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:29 pm -
1 stop9h 00m
Deal found 8/6![Frontier logo]()
$72
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/46:17 pm -
1 stop14h 39m
Deal found 8/5![Frontier logo]()
$73
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/306:17 pm -
1 stop13h 15m
Deal found 8/3![Frontier logo]()
$79
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/92:29 pm -
1 stop9h 00m
Deal found 8/6![Frontier logo]()
$80
Find flight deals from St. Louis to Durham
Keep the following information in mind while searching for St. Louis to Durham flight deals. Data was last updated August 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $130 (Kiwi.com) |
One-way from | $64 (Kiwi.com) |
Popular in | May |
Cheapest in | October |
Average price | $488 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 7, 2026.
Use the filters below to find and compare flights from St. Louis to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisRaleigh
STL Lambert-St Louis - RDU Raleigh-Durham
STLRDU
Lambert-St Louis
Thu 8/27
3:39 pm-11:25 pm
1 stop6h 46m
Raleigh-Durham
Tue 9/15
9:50 am-1:06 pm
1 stop4h 16m
$315
Quickest round-trip
St. LouisRaleigh
STL Lambert-St Louis - RDU Raleigh-Durham
STLRDU
Lambert-St Louis
Thu 10/1
10:20 am-1:10 pm
Nonstop1h 50m
Raleigh-Durham
Mon 10/5
6:00 am-7:10 am
Nonstop2h 10m
$315
St. LouisRaleigh
STL Lambert-St Louis - RDU Raleigh-Durham
STLRDU
Lambert-St Louis
Mon 8/31
12:27 pm-6:40 pm
1 stop5h 13m
Raleigh-Durham
Tue 9/1
6:00 am-9:39 am
1 stop4h 39m
$320
St. LouisRaleigh
STL Lambert-St Louis - RDU Raleigh-Durham
STLRDU
Lambert-St Louis
Wed 10/28
5:35 pm-12:28 am
1 stop5h 53m
Raleigh-Durham
Tue 11/3
8:00 am-1:39 pm
1 stop6h 39m
$325
St. LouisRaleigh
STL Lambert-St Louis - RDU Raleigh-Durham
STLRDU
Lambert-St Louis
Mon 8/31
12:55 pm-8:50 pm
1 stop6h 55m
Raleigh-Durham
Tue 9/1
6:55 pm-8:00 pm
Nonstop2h 05m
$325
St. LouisRaleigh
STL Lambert-St Louis - RDU Raleigh-Durham
STLRDU
Lambert-St Louis
Wed 10/21
8:30 am-5:00 pm
2 stops7h 30m
Raleigh-Durham
Wed 10/21
6:05 pm-10:15 pm
1 stop5h 10m
$340
St. LouisRaleigh
STL Lambert-St Louis - RDU Raleigh-Durham
STLRDU
Lambert-St Louis
Fri 10/2
5:50 pm-11:10 pm
1 stop4h 20m
Raleigh-Durham
Sun 10/4
6:10 am-7:20 am
Nonstop2h 10m
$367
St. LouisRaleigh
STL Lambert-St Louis - RDU Raleigh-Durham
STLRDU
Lambert-St Louis
Mon 8/31
8:30 am-5:25 pm
2 stops7h 55m
Raleigh-Durham
Mon 8/31
6:30 pm-9:40 pm
1 stop4h 10m
$381
St. LouisRaleigh
STL Lambert-St Louis - RDU Raleigh-Durham
STLRDU
Lambert-St Louis
Wed 10/28
5:00 am-2:07 pm
2 stops8h 07m
Raleigh-Durham
Tue 11/3
6:15 am-10:32 am
1 stop5h 17m
$390
St. LouisRaleigh
STL Lambert-St Louis - RDU Raleigh-Durham
STLRDU
Lambert-St Louis
Wed 10/21
8:30 am-6:25 pm
2 stops8h 55m
Raleigh-Durham
Sun 10/25
10:20 am-5:15 pm
2 stops7h 55m
$426
Showing 1-10 of 22 resultsSorted by cheapest first
Best time to book a flight from St. Louis to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from St. Louis with our price prediction graph.
STL-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Durham
STL-DU8
STL-RDU
What is the cheapest time of day to fly from STL to DU8?
Find hourly flight availability from St. Louis to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 7, 2026.
It’s optimal to fly from St. Louis to Durham at noon. By choosing this option you can save up to 13% on the cost of your flight, compared to a flight in the afternoon.
How much does it cost to fly round-trip from St. Louis to Durham?
Airfare is below average for this route at the moment.
St. Louis to Durham flights typically cost between $351 and $581 in September.The cheapest round-trip price found within the last 5 days was $130 on Frontier (Sep 11-Sep 14).
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated August 7, 2026.
See what other customers who have flown with Southwest,Delta, andAmerican Airlines from St. Louis to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
6.0
GoodLauren,Dec 2024
MCI - DCA
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
6.0
GoodLauren,Dec 2024
MCI - DCA
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
6.0
GoodLauren,Dec 2024
MCI - DCA
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
6.0
GoodLauren,Dec 2024
MCI - DCA
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
6.0
GoodLauren,Dec 2024
MCI - DCA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from St. Louis
Popular flights
Top destinations
Alternative routes for St. Louis to Durham
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Durham by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Durham by cabin class
Find flights from St. Louis to Durham, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Durham flights
Browse other St. Louis and Durham flight options. Last updated on August 7, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on August 7, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
St. Louis to Durham flights
Consider these flights traveling from St. Louis to Durham.
Top 4 airlines flying from St. Louis to Durham
Discover the top 4 airlines that operate flights from St. Louis to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$126 | Average$191 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$127 | Average$387 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$196 | Average$426 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$297 | Average$464 | FlexibilityNo cancel fee | On-time63% |