Durham

$59+ Cheap flights from St. Louis (STL) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/26. Fares are subject to change and may not be available on all flights or dates of travel.
STL — RDU
May 31 — Jun 71
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Cheapflights Tip: The best prices from Lambert-St Louis to Durham are usually found in October or January, booked 58 days in advance, depart on a Saturday or Sunday and return on a Wednesday

Cheap flight deals from St. Louis to Durham

Cheapest flights from St. Louis to Durham
Explore the most affordable flight options available from St. Louis to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:27 pm
STL
-
RDU
1 stop6h 06m
Frontier
Tue 6/912:54 pm
RDU
-
STL
1 stop5h 36m
Frontier
Deal found 4/30$124
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
-
RDU
1 stop5h 00m
Frontier
Tue 6/26:15 am
RDU
-
STL
1 stop12h 18m
Frontier
Deal found 4/29$126
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
-
RDU
1 stop5h 00m
Frontier
Fri 5/296:15 am
RDU
-
STL
1 stop27h 40m
Frontier
Deal found 4/30$129
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:27 pm
STL
-
RDU
1 stop5h 57m
Frontier
Thu 6/412:54 pm
RDU
-
STL
1 stop5h 39m
Frontier
Deal found 4/26$133
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:27 pm
STL
-
RDU
1 stop17h 32m
Frontier
Thu 6/412:54 pm
RDU
-
STL
1 stop5h 39m
Frontier
Deal found 4/29$136
This Frontier deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:27 pm
STL
-
RDU
1 stop5h 59m
Frontier
Sun 5/2412:54 pm
RDU
-
STL
1 stop5h 39m
Frontier
Deal found 4/30$140
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
-
RDU
1 stop12h 31m
Frontier
Wed 6/32:17 pm
RDU
-
STL
1 stop10h 40m
Frontier
Deal found 4/29$151
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:27 pm
STL
-
RDU
1 stop17h 32m
Frontier
Fri 6/52:42 pm
RDU
-
STL
1 stop10h 15m
Frontier
Deal found 4/29$158
This Frontier deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
-
RDU
1 stop5h 00m
Frontier
Sat 6/68:25 am
RDU
-
STL
1 stop6h 30m
Frontier
Deal found 4/29$160
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/314:19 pm
STL
-
RDU
1 stop16h 02m
Frontier
Tue 6/212:54 pm
RDU
-
STL
1 stop5h 39m
Frontier
Deal found 4/29$162
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:27 pm
STL
-
RDU
1 stop5h 59m
Frontier
Mon 5/257:52 pm
RDU
-
STL
2 stops38h 03m
Frontier
Deal found 4/27$166
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:27 pm
STL
-
RDU
2 stops16h 25m
Multiple Airlines
Tue 6/96:00 am
RDU
-
STL
1 stop12h 30m
Multiple Airlines
Deal found 4/30$167

Find flight deals from St. Louis to Durham

Keep the following information in mind while searching for St. Louis to Durham flight deals. Data was last updated May 1, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$124
(Kiwi.com)

One-way from

$59
(Trip.com)

Popular in

August

Cheapest in

October

Average price

$384
Provider with most accurate pricing for Lambert-St Louis-Raleigh-Durham flight deals.
Provider most trusted by Cheapflights users for Lambert-St Louis-Raleigh-Durham flights.
From Lambert-St Louis to Durham
One-way flight from Lambert-St Louis to Durham
Highest demand for flights based on searches. 11% potential increase in price ($51 potential increase over avg. RT price).
Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
Average for round-trip flights in May 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2026.
Use the filters below to find and compare flights from St. Louis to Durham that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Wed 6/3

6:50 pm-9:40 pm

Nonstop1h 50m

Raleigh-Durham

Tue 6/9

6:35 am-7:40 am

Nonstop2h 05m

$297

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Tue 5/26

6:50 pm-9:40 pm

Nonstop1h 50m

Raleigh-Durham

Tue 6/2

6:10 am-7:20 am

Nonstop2h 10m

$297

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Wed 5/27

7:35 am-12:45 pm

1 stop4h 10m

Raleigh-Durham

Wed 6/3

6:45 pm-8:00 pm

Nonstop2h 15m

$307

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Mon 6/1

1:55 pm-10:45 pm

1 stop7h 50m

Raleigh-Durham

Wed 6/3

6:45 pm-8:00 pm

Nonstop2h 15m

$322

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Mon 6/1

4:40 pm-9:45 pm

1 stop4h 05m

Raleigh-Durham

Thu 6/4

7:55 pm-9:00 pm

Nonstop2h 05m

$337

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Thu 5/28

6:00 am-2:08 pm

2 stops7h 08m

Raleigh-Durham

Mon 6/1

5:07 pm-9:16 pm

1 stop5h 09m

$370

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Mon 5/25

7:45 pm-10:35 pm

Nonstop1h 50m

Raleigh-Durham

Fri 5/29

7:45 pm-8:55 pm

Nonstop2h 10m

$408

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Thu 6/18

2:30 pm-8:35 pm

1 stop5h 05m

Raleigh-Durham

Sun 6/21

6:25 am-7:30 am

Nonstop2h 05m

$413

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Sun 5/17

5:00 am-1:25 pm

1 stop7h 25m

Raleigh-Durham

Wed 5/20

6:45 pm-8:00 pm

Nonstop2h 15m

$439
Cheapest one-way

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Mon 6/8

5:27 pm-12:24 am

1 stop5h 57m

$66

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/27

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Best time to book a flight from St. Louis to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Durham

What is the cheapest time of day to fly from STL to DU8?

Find hourly flight availability from St. Louis to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2026.

It’s optimal to fly from St. Louis to Durham in the afternoon. By choosing this option you can save up to 12% on the cost of your flight, compared to a flight at noon.

How much does it cost to fly round-trip from St. Louis to Durham?

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated May 1, 2026.
See what other customers who have flown with Southwest,Delta, andAmerican Airlines from St. Louis to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Comfort

8.0

Boarding

8.1

Overall

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Comfort

8.0

Boarding

8.1

Overall

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Comfort

8.0

Boarding

8.1

Overall

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Comfort

8.0

Boarding

8.1

Overall

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Comfort

8.0

Boarding

8.1

Overall

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from St. Louis to Durham?

    Lambert-St Louis (STL), located 12.7 mi from the city center, is the airport you fly out of when you book flights from St. Louis to Durham. 4 airlines have flights from Lambert-St Louis to Durham on a regular basis. Booking flights from Lambert-St Louis to Durham should not be difficult; the airport handles an average of 1 outbound flight to Durham per day.

  • How popular is this St. Louis to Durham flight route?

  • How long is the flight from St. Louis to Durham?

    There are many flights that can get you from St. Louis to Durham in 1h 50m. Fly via Southwest to get the fastest option. The distance from St. Louis to Durham is about 666 mi. Generally, flights for this route are nonstop.

  • What are the cheapest airlines to fly from St. Louis to Durham one-way?

    $72 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $103 and $126, respectively.

  • What are the cheapest flights from St. Louis to Durham?

    Looking for the cheapest flight from St. Louis to Durham? While on average our users pay $460, our data indicates the cheapest price to be $205. The most popular route (Lambert-St Louis - Raleigh-Durham), is priced around $175.

  • Can I find deals for flights from St. Louis to Durham that include hotel bookings?

    Yes. In addition to deals on St. Louis to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Durham.

  • Can I find deals for business class flights from St. Louis to Durham?

    Yes. Cheapflights offers flight deals from St. Louis to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top 4 airlines flying from St. Louis to Durham

Discover the top 4 airlines that operate flights from St. Louis to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$134Average$185FlexibilityNo cancel feeOn-time62%
DeltaCheapest$196Average$363FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$196Average$384FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$231Average$424FlexibilityNo cancel feeOn-time63%

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