$59+ Cheap flights from St. Louis (STL) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/26. Fares are subject to change and may not be available on all flights or dates of travel.
STL — RDU
May 31 — Jun 71
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Durham with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Lambert-St Louis to Durham are usually found in October or January, booked 58 days in advance, depart on a Saturday or Sunday and return on a Wednesday
Cheap flight deals from St. Louis to Durham
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to DurhamExplore the most affordable flight options available from St. Louis to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2026.
Explore the most affordable flight options available from St. Louis to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:27 pm
STL
- RDU
1 stop6h 06m
Frontier
Tue 6/912:54 pm
RDU
- STL
1 stop5h 36m
Frontier
Deal found 4/30![Frontier logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- RDU
1 stop5h 00m
Frontier
Tue 6/26:15 am
RDU
- STL
1 stop12h 18m
Frontier
Deal found 4/29![Frontier logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- RDU
1 stop5h 00m
Frontier
Fri 5/296:15 am
RDU
- STL
1 stop27h 40m
Frontier
Deal found 4/30![Frontier logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:27 pm
STL
- RDU
1 stop5h 57m
Frontier
Thu 6/412:54 pm
RDU
- STL
1 stop5h 39m
Frontier
Deal found 4/26![Frontier logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:27 pm
STL
- RDU
1 stop17h 32m
Frontier
Thu 6/412:54 pm
RDU
- STL
1 stop5h 39m
Frontier
Deal found 4/29![Frontier logo]()
$136
This Frontier deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:27 pm
STL
- RDU
1 stop5h 59m
Frontier
Sun 5/2412:54 pm
RDU
- STL
1 stop5h 39m
Frontier
Deal found 4/30![Frontier logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- RDU
1 stop12h 31m
Frontier
Wed 6/32:17 pm
RDU
- STL
1 stop10h 40m
Frontier
Deal found 4/29![Frontier logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:27 pm
STL
- RDU
1 stop17h 32m
Frontier
Fri 6/52:42 pm
RDU
- STL
1 stop10h 15m
Frontier
Deal found 4/29![Frontier logo]()
$158
This Frontier deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- RDU
1 stop5h 00m
Frontier
Sat 6/68:25 am
RDU
- STL
1 stop6h 30m
Frontier
Deal found 4/29![Frontier logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/314:19 pm
STL
- RDU
1 stop16h 02m
Frontier
Tue 6/212:54 pm
RDU
- STL
1 stop5h 39m
Frontier
Deal found 4/29![Frontier logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:27 pm
STL
- RDU
1 stop5h 59m
Frontier
Mon 5/257:52 pm
RDU
- STL
2 stops38h 03m
Frontier
Deal found 4/27![Frontier logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:27 pm
STL
- RDU
2 stops16h 25m
Multiple Airlines
Tue 6/96:00 am
RDU
- STL
1 stop12h 30m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$167
Best flights from St. Louis to DurhamDiscover carefully curated flight deals from St. Louis to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2026.
Discover carefully curated flight deals from St. Louis to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2026.
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:50 pm
STL
- RDU
Nonstop1h 50m
Southwest
Tue 6/96:35 am
RDU
- STL
Nonstop2h 05m
Southwest
Deal found 4/30![Southwest logo]()
$297
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
STL
- RDU
2 stops7h 08m
United Airlines
Mon 6/15:07 pm
RDU
- STL
1 stop5h 09m
United Airlines
Deal found 4/26![United Airlines logo]()
$370
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:50 pm
STL
- RDU
Nonstop1h 50m
Southwest
Tue 6/26:10 am
RDU
- STL
Nonstop2h 10m
Southwest
Deal found 4/28![Southwest logo]()
$297
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:35 am
STL
- RDU
1 stop4h 10m
Southwest
Wed 6/36:45 pm
RDU
- STL
Nonstop2h 15m
Southwest
Deal found 4/27![Southwest logo]()
$307
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:55 pm
STL
- RDU
1 stop7h 50m
Southwest
Wed 6/36:45 pm
RDU
- STL
Nonstop2h 15m
Southwest
Deal found 4/26![Southwest logo]()
$322
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/14:40 pm
STL
- RDU
1 stop4h 05m
Southwest
Thu 6/47:55 pm
RDU
- STL
Nonstop2h 05m
Southwest
Deal found 4/26![Southwest logo]()
$337
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:45 pm
STL
- RDU
Nonstop1h 50m
Southwest
Fri 5/297:45 pm
RDU
- STL
Nonstop2h 10m
Southwest
Deal found 4/26![Southwest logo]()
$408
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/182:30 pm
STL
- RDU
1 stop5h 05m
Southwest
Sun 6/216:25 am
RDU
- STL
Nonstop2h 05m
Southwest
Deal found 4/30![Southwest logo]()
$413
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:00 am
STL
- RDU
1 stop7h 25m
Southwest
Wed 5/206:45 pm
RDU
- STL
Nonstop2h 15m
Southwest
Deal found 4/27![Southwest logo]()
$439
Last-minute flights from St. Louis to DurhamDiscover last-minute flight deals from St. Louis to Durham. Data last updated May 1, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Durham. Data last updated May 1, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:27 pm
STL
- RDU
1 stop5h 59m
Frontier
Sun 5/2412:54 pm
RDU
- STL
1 stop5h 39m
Frontier
Deal found 4/30![Frontier logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:27 pm
STL
- RDU
1 stop5h 59m
Frontier
Mon 5/257:52 pm
RDU
- STL
2 stops38h 03m
Frontier
Deal found 4/27![Frontier logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:27 pm
STL
- RDU
1 stop17h 32m
Frontier
Thu 6/412:54 pm
RDU
- STL
1 stop5h 39m
Frontier
Deal found 4/29![Frontier logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:27 pm
STL
- RDU
1 stop17h 32m
Frontier
Fri 6/52:42 pm
RDU
- STL
1 stop10h 15m
Frontier
Deal found 4/29![Frontier logo]()
$158
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- RDU
1 stop5h 00m
Frontier
Tue 6/212:54 pm
RDU
- STL
1 stop5h 39m
Frontier
Deal found 4/28![Frontier logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- RDU
1 stop5h 00m
Frontier
Fri 5/296:15 am
RDU
- STL
1 stop27h 40m
Frontier
Deal found 4/30![Frontier logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- RDU
1 stop12h 31m
Frontier
Wed 6/32:17 pm
RDU
- STL
1 stop10h 40m
Frontier
Deal found 4/29![Frontier logo]()
$151
This Frontier deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- RDU
1 stop5h 00m
Frontier
Sat 6/68:25 am
RDU
- STL
1 stop6h 30m
Frontier
Deal found 4/29![Frontier logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:27 pm
STL
- RDU
1 stop6h 06m
Multiple Airlines
Mon 6/12:32 pm
RDU
- STL
1 stop10h 25m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$169
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/314:19 pm
STL
- RDU
1 stop16h 02m
Frontier
Tue 6/212:54 pm
RDU
- STL
1 stop5h 39m
Frontier
Deal found 4/29![Frontier logo]()
$162
One-way flights from St. Louis to DurhamSearch for one-way flight options from St. Louis to Durham. Find affordable one-way fares based on user searches. Data last updated May 1, 2026.
Search for one-way flight options from St. Louis to Durham. Find affordable one-way fares based on user searches. Data last updated May 1, 2026.
This Trip.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- RDU
1 stop12h 31m
Frontier
Deal found 4/30![Frontier logo]()
$59
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:06 pm
STL
- RDU
1 stop6h 15m
Frontier
Deal found 4/29![Frontier logo]()
$63
This Trip.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:27 pm
STL
- RDU
1 stop5h 57m
Frontier
Deal found 4/27![Frontier logo]()
$66
This Frontier deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:27 pm
STL
- RDU
1 stop5h 59m
Frontier
Deal found 4/29![Frontier logo]()
$70
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:27 pm
STL
- RDU
1 stop17h 32m
Frontier
Deal found 4/28![Frontier logo]()
$71
This Priceline deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:33 pm
STL
- RDU
1 stop5h 00m
Frontier
Deal found 4/27![Frontier logo]()
$90
This Frontier deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/224:52 pm
STL
- RDU
1 stop6h 33m
Frontier
Deal found 4/27![Frontier logo]()
$95
This Trip.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/256:31 pm
STL
- RDU
1 stop12h 32m
Frontier
Deal found 4/27![Frontier logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:27 pm
STL
- RDU
2 stops16h 25m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$99
Find flight deals from St. Louis to Durham
Keep the following information in mind while searching for St. Louis to Durham flight deals. Data was last updated May 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $124 (Kiwi.com) |
One-way from | $59 (Trip.com) |
Popular in | August |
Cheapest in | October |
Average price | $384 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2026.
Use the filters below to find and compare flights from St. Louis to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Wed 6/3
6:50 pm-9:40 pm
Nonstop1h 50m
Raleigh-Durham
Tue 6/9
6:35 am-7:40 am
Nonstop2h 05m
$297
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Tue 5/26
6:50 pm-9:40 pm
Nonstop1h 50m
Raleigh-Durham
Tue 6/2
6:10 am-7:20 am
Nonstop2h 10m
$297
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Wed 5/27
7:35 am-12:45 pm
1 stop4h 10m
Raleigh-Durham
Wed 6/3
6:45 pm-8:00 pm
Nonstop2h 15m
$307
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Mon 6/1
1:55 pm-10:45 pm
1 stop7h 50m
Raleigh-Durham
Wed 6/3
6:45 pm-8:00 pm
Nonstop2h 15m
$322
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Mon 6/1
4:40 pm-9:45 pm
1 stop4h 05m
Raleigh-Durham
Thu 6/4
7:55 pm-9:00 pm
Nonstop2h 05m
$337
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Thu 5/28
6:00 am-2:08 pm
2 stops7h 08m
Raleigh-Durham
Mon 6/1
5:07 pm-9:16 pm
1 stop5h 09m
$370
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Mon 5/25
7:45 pm-10:35 pm
Nonstop1h 50m
Raleigh-Durham
Fri 5/29
7:45 pm-8:55 pm
Nonstop2h 10m
$408
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Thu 6/18
2:30 pm-8:35 pm
1 stop5h 05m
Raleigh-Durham
Sun 6/21
6:25 am-7:30 am
Nonstop2h 05m
$413
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Sun 5/17
5:00 am-1:25 pm
1 stop7h 25m
Raleigh-Durham
Wed 5/20
6:45 pm-8:00 pm
Nonstop2h 15m
$439
Cheapest one-way
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Mon 6/8
5:27 pm-12:24 am
1 stop5h 57m
$66
Showing 1-10 of 17 resultsSorted by cheapest first
Best time to book a flight from St. Louis to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from St. Louis with our price prediction graph.
STL-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Durham
STL-DU8
STL-RDU
What is the cheapest time of day to fly from STL to DU8?
Find hourly flight availability from St. Louis to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2026.
It’s optimal to fly from St. Louis to Durham in the afternoon. By choosing this option you can save up to 12% on the cost of your flight, compared to a flight at noon.
How much does it cost to fly round-trip from St. Louis to Durham?
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated May 1, 2026.
See what other customers who have flown with Southwest,Delta, andAmerican Airlines from St. Louis to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
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Top 4 airlines flying from St. Louis to Durham
Discover the top 4 airlines that operate flights from St. Louis to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$134 | Average$185 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$196 | Average$363 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$196 | Average$384 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$231 | Average$424 | FlexibilityNo cancel fee | On-time63% |