$81+ Cheap flights from St. Louis (STL) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — RDU
Jul 16 — Jul 231
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Durham with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Lambert-St Louis to Durham are usually found in October or January, booked 58 days in advance, depart on a Saturday or Wednesday and return on a Wednesday
Cheap flight deals from St. Louis to Durham
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Best
Last-minute
One-way
Cheapest flights from St. Louis to DurhamExplore the most affordable flight options available from St. Louis to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2026.
Explore the most affordable flight options available from St. Louis to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:34 pm
STL
- RDU
1 stop12h 37m
Frontier
Fri 8/712:04 pm
RDU
- STL
1 stop21h 53m
Frontier
Deal found 6/12![Frontier logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/34:57 pm
STL
- RDU
1 stop6h 07m
Frontier
Sun 8/96:14 pm
RDU
- STL
1 stop15h 43m
Frontier
Deal found 6/11![Frontier logo]()
$164
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/84:57 pm
STL
- RDU
1 stop6h 07m
Frontier
Sun 7/126:14 pm
RDU
- STL
1 stop15h 43m
Frontier
Deal found 6/15![Frontier logo]()
$167
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1710:35 am
STL
- RDU
1 stop12h 42m
Frontier
Sun 9/204:20 pm
RDU
- STL
1 stop18h 20m
Frontier
Deal found 6/11![Frontier logo]()
$186
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:34 pm
STL
- RDU
1 stop12h 37m
Frontier
Sun 7/196:15 am
RDU
- STL
1 stop27h 42m
Frontier
Deal found 6/14![Frontier logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:06 pm
STL
- RDU
1 stop13h 57m
Frontier
Sun 7/56:14 pm
RDU
- STL
1 stop15h 43m
Frontier
Deal found 6/13![Frontier logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:33 pm
STL
- RDU
1 stop12h 30m
Frontier
Mon 8/248:06 pm
RDU
- STL
2 stops22h 24m
Frontier
Deal found 6/14![Frontier logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:33 pm
STL
- RDU
2 stops21h 36m
Frontier
Tue 9/156:35 am
RDU
- STL
1 stop28h 05m
Frontier
Deal found 6/15![Frontier logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/134:57 pm
STL
- RDU
1 stop6h 07m
Frontier
Mon 7/207:32 pm
RDU
- STL
2 stops23h 05m
Frontier
Deal found 6/15![Frontier logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/34:57 pm
STL
- RDU
1 stop6h 07m
Frontier
Mon 8/106:15 am
RDU
- STL
2 stops33h 41m
Frontier
Deal found 6/11![Frontier logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:34 pm
STL
- RDU
2 stops19h 35m
Multiple Airlines
Fri 8/712:04 pm
RDU
- STL
1 stop21h 53m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/14:57 pm
STL
- RDU
1 stop6h 06m
Multiple Airlines
Mon 8/38:29 pm
RDU
- STL
1 stop28h 30m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$214
Best flights from St. Louis to DurhamDiscover carefully curated flight deals from St. Louis to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 16, 2026.
Discover carefully curated flight deals from St. Louis to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 16, 2026.
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/217:10 pm
STL
- RDU
Nonstop1h 55m
Southwest
Tue 7/286:35 am
RDU
- STL
Nonstop2h 05m
Southwest
Deal found 6/11![Southwest logo]()
$297
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:25 am
STL
- RDU
2 stops10h 15m
United Airlines
Wed 8/196:00 am
RDU
- STL
2 stops10h 38m
United Airlines
Deal found 6/11![United Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/89:40 am
STL
- RDU
1 stop3h 35m
Southwest
Sat 7/116:15 pm
RDU
- STL
Nonstop2h 05m
Southwest
Deal found 6/15![Southwest logo]()
$313
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/199:00 am
STL
- RDU
Nonstop1h 50m
Southwest
Tue 9/226:15 am
RDU
- STL
Nonstop2h 05m
Southwest
Deal found 6/14![Southwest logo]()
$316
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:00 am
STL
- RDU
1 stop5h 07m
United Airlines
Wed 8/266:55 am
RDU
- STL
2 stops9h 43m
United Airlines
Deal found 6/15![United Airlines logo]()
$374
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:00 am
STL
- RDU
2 stops7h 07m
United Airlines
Tue 9/156:25 am
RDU
- STL
2 stops10h 13m
United Airlines
Deal found 6/11![United Airlines logo]()
$402
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am
STL
- RDU
1 stop4h 15m
Southwest
Sat 10/316:25 am
RDU
- STL
Nonstop2h 05m
Southwest
Deal found 6/11![Southwest logo]()
$377
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:55 pm
STL
- RDU
Nonstop1h 50m
Southwest
Sun 7/57:50 pm
RDU
- STL
Nonstop2h 05m
Southwest
Deal found 6/13![Southwest logo]()
$403
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/159:00 am
STL
- RDU
Nonstop1h 50m
Southwest
Sun 8/235:20 am
RDU
- STL
1 stop6h 20m
Southwest
Deal found 6/12![Southwest logo]()
$412
Last-minute flights from St. Louis to DurhamDiscover last-minute flight deals from St. Louis to Durham. Data last updated June 16, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Durham. Data last updated June 16, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:06 pm
STL
- RDU
1 stop13h 57m
Frontier
Sun 7/56:14 pm
RDU
- STL
1 stop15h 43m
Frontier
Deal found 6/13![Frontier logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:06 pm
STL
- RDU
1 stop6h 15m
Frontier
Mon 7/67:32 pm
RDU
- STL
2 stops23h 05m
Frontier
Deal found 6/11![Frontier logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/84:57 pm
STL
- RDU
1 stop6h 07m
Frontier
Sun 7/126:14 pm
RDU
- STL
1 stop15h 43m
Frontier
Deal found 6/15![Frontier logo]()
$167
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/84:57 pm
STL
- RDU
1 stop6h 07m
Multiple Airlines
Sat 7/119:48 pm
RDU
- STL
2 stops36h 09m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:34 pm
STL
- RDU
1 stop12h 37m
Multiple Airlines
Mon 7/139:27 pm
RDU
- STL
2 stops21h 10m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:34 pm
STL
- RDU
1 stop12h 37m
Frontier
Sun 7/196:15 am
RDU
- STL
1 stop27h 42m
Frontier
Deal found 6/14![Frontier logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/134:57 pm
STL
- RDU
1 stop6h 07m
Frontier
Mon 7/207:32 pm
RDU
- STL
2 stops23h 05m
Frontier
Deal found 6/15![Frontier logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/154:57 pm
STL
- RDU
1 stop6h 07m
Multiple Airlines
Sat 8/19:48 pm
RDU
- STL
2 stops36h 09m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:34 pm
STL
- RDU
1 stop12h 37m
Frontier
Tue 7/216:15 am
RDU
- STL
1 stop12h 22m
Frontier
Deal found 6/15![Frontier logo]()
$164
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:34 pm
STL
- RDU
1 stop12h 37m
Frontier
Tue 7/2810:34 pm
RDU
- STL
2 stops44h 03m
Frontier
Deal found 6/11![Frontier logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:34 pm
STL
- RDU
1 stop12h 37m
Multiple Airlines
Mon 7/278:29 pm
RDU
- STL
1 stop28h 30m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$230
One-way flights from St. Louis to DurhamSearch for one-way flight options from St. Louis to Durham. Find affordable one-way fares based on user searches. Data last updated June 16, 2026.
Search for one-way flight options from St. Louis to Durham. Find affordable one-way fares based on user searches. Data last updated June 16, 2026.
This Trip.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/154:57 pm
STL
- RDU
1 stop6h 07m
Frontier
Deal found 6/11![Frontier logo]()
$81
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/266:34 pm
STL
- RDU
1 stop12h 37m
Frontier
Deal found 6/14![Frontier logo]()
$85
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/104:57 pm
STL
- RDU
1 stop6h 07m
Frontier
Deal found 6/11![Frontier logo]()
$87
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:33 pm
STL
- RDU
1 stop19h 34m
Frontier
Deal found 6/11![Frontier logo]()
$99
This Trip.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1110:35 am
STL
- RDU
1 stop12h 42m
Frontier
Deal found 6/14![Frontier logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:06 pm
STL
- RDU
1 stop17h 53m
Frontier
Deal found 6/11![Frontier logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:33 pm
STL
- RDU
1 stop5h 49m
Frontier
Deal found 6/11![Frontier logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:34 pm
STL
- RDU
1 stop12h 37m
Frontier
Deal found 6/13![Frontier logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:34 pm
STL
- RDU
2 stops19h 35m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:33 pm
STL
- RDU
2 stops23h 38m
Frontier
Deal found 6/15![Frontier logo]()
$131
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/810:15 am
STL
- RDU
Nonstop1h 50m
Southwest
Deal found 6/11![Southwest logo]()
$132
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:20 am
STL
- RDU
1 stop5h 47m
Delta
Deal found 6/11![Delta logo]()
$135
Find flight deals from St. Louis to Durham
Keep the following information in mind while searching for St. Louis to Durham flight deals. Data was last updated June 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $159 (Kiwi.com) |
One-way from | $81 (Trip.com) |
Popular in | May |
Cheapest in | October |
Average price | $403 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
Use the filters below to find and compare flights from St. Louis to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Tue 7/21
7:10 pm-10:05 pm
Nonstop1h 55m
Raleigh-Durham
Tue 7/28
6:35 am-7:40 am
Nonstop2h 05m
$297
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Wed 7/8
9:40 am-2:15 pm
1 stop3h 35m
Raleigh-Durham
Sat 7/11
6:15 pm-7:20 pm
Nonstop2h 05m
$313
Quickest round-trip
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Sat 9/19
9:00 am-11:50 am
Nonstop1h 50m
Raleigh-Durham
Tue 9/22
6:15 am-7:20 am
Nonstop2h 05m
$316
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Tue 8/18
7:25 am-6:40 pm
2 stops10h 15m
Raleigh-Durham
Wed 8/19
6:00 am-3:38 pm
2 stops10h 38m
$369
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Tue 8/25
8:00 am-2:07 pm
1 stop5h 07m
Raleigh-Durham
Wed 8/26
6:55 am-3:38 pm
2 stops9h 43m
$374
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Sat 10/24
6:00 am-11:15 am
1 stop4h 15m
Raleigh-Durham
Sat 10/31
6:25 am-7:30 am
Nonstop2h 05m
$377
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Thu 8/27
6:00 am-2:07 pm
2 stops7h 07m
Raleigh-Durham
Tue 9/15
6:25 am-3:38 pm
2 stops10h 13m
$402
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Fri 7/3
7:55 pm-10:45 pm
Nonstop1h 50m
Raleigh-Durham
Sun 7/5
7:50 pm-8:55 pm
Nonstop2h 05m
$403
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Sat 8/15
9:00 am-11:50 am
Nonstop1h 50m
Raleigh-Durham
Sun 8/23
5:20 am-10:40 am
1 stop6h 20m
$412
Cheapest one-way
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Tue 12/8
7:20 am-2:07 pm
1 stop5h 47m
$135
Showing 1-10 of 19 resultsSorted by cheapest first
Best time to book a flight from St. Louis to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from St. Louis with our price prediction graph.
STL-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Durham
STL-DU8
STL-RDU
What is the cheapest time of day to fly from STL to DU8?
Find hourly flight availability from St. Louis to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 16, 2026.
It’s optimal to fly from St. Louis to Durham in the morning. By choosing this option you can save up to 14% on the cost of your flight, compared to a flight in the afternoon.
How much does it cost to fly round-trip from St. Louis to Durham?
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated June 16, 2026.
See what other customers who have flown with Southwest,Delta, andAmerican Airlines from St. Louis to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for St. Louis to Durham
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Complete your trip
Complete your trip to Durham by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Durham by cabin class
Find flights from St. Louis to Durham, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Durham flights
Browse other St. Louis and Durham flight options. Last updated on June 16, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on June 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
St. Louis to Durham flights
Consider these flights traveling from St. Louis to Durham.
Top 4 airlines flying from St. Louis to Durham
Discover the top 4 airlines that operate flights from St. Louis to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$126 | Average$180 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$127 | Average$373 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$196 | Average$412 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$231 | Average$444 | FlexibilityNo cancel fee | On-time63% |