$70+ Cheap flights from St. Louis (STL) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — RDU
Apr 17 — Apr 241
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Durham with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Lambert-St Louis to Durham are usually found in October or January, booked 58 days in advance, depart on a Monday or Wednesday and return on a Wednesday
Cheap flight deals from St. Louis to Durham
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to DurhamExplore the most affordable flight options available from St. Louis to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 18, 2026.
Explore the most affordable flight options available from St. Louis to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:23 pm
STL
- RDU
1 stop12h 07m
Frontier
Sun 5/33:42 pm
RDU
- STL
1 stop16h 08m
Frontier
Deal found 3/17![Frontier logo]()
$163
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:23 pm
STL
- RDU
1 stop11h 43m
Frontier
Wed 4/224:00 pm
RDU
- STL
1 stop19h 30m
Frontier
Deal found 3/15![Frontier logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:55 pm
STL
- RDU
1 stop12h 09m
Frontier
Sun 5/1712:54 pm
RDU
- STL
1 stop21h 01m
Frontier
Deal found 3/17![Frontier logo]()
$169
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:19 pm
STL
- RDU
1 stop20h 43m
Frontier
Tue 4/147:37 pm
RDU
- STL
1 stop28h 42m
Frontier
Deal found 3/15![Frontier logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:21 am
STL
- RDU
1 stop10h 59m
Frontier
Thu 5/712:54 pm
RDU
- STL
1 stop5h 00m
Frontier
Deal found 3/16![Frontier logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:55 pm
STL
- RDU
1 stop12h 09m
Frontier
Mon 5/118:40 pm
RDU
- STL
2 stops37h 15m
Frontier
Deal found 3/17![Frontier logo]()
$187
This Gotogate deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/204:59 pm
STL
- RDU
1 stop22h 57m
Frontier
Tue 4/217:37 pm
RDU
- STL
1 stop28h 42m
Frontier
Deal found 3/15![Frontier logo]()
$189
This Mytrip deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/284:59 pm
STL
- RDU
1 stop16h 00m
Frontier
Tue 5/512:54 pm
RDU
- STL
1 stop5h 42m
Frontier
Deal found 3/14![Frontier logo]()
$190
This CheapOair deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/144:59 pm
STL
- RDU
1 stop16h 00m
Frontier
Fri 4/178:43 pm
RDU
- STL
1 stop27h 36m
Frontier
Deal found 3/17![Frontier logo]()
$191
This Frontier deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:21 am
STL
- RDU
1 stop10h 59m
Frontier
Sat 5/211:53 am
RDU
- STL
1 stop12h 26m
Frontier
Deal found 3/15![Frontier logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:27 pm
STL
- RDU
1 stop13h 37m
Multiple Airlines
Mon 5/116:03 pm
RDU
- STL
2 stops24h 30m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$206
Best flights from St. Louis to DurhamDiscover carefully curated flight deals from St. Louis to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 18, 2026.
Discover carefully curated flight deals from St. Louis to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 18, 2026.
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/137:45 pm
STL
- RDU
Nonstop1h 50m
Southwest
Wed 4/156:45 pm
RDU
- STL
Nonstop2h 15m
Southwest
Deal found 3/13![Southwest logo]()
$317
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:30 am
STL
- RDU
2 stops6h 36m
United Airlines
Sun 4/56:00 am
RDU
- STL
1 stop5h 28m
United Airlines
Deal found 3/13![United Airlines logo]()
$344
This CheapOair deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/24:54 pm
STL
- RDU
1 stop14h 02m
Frontier
Sun 4/56:00 am
RDU
- STL
1 stop5h 30m
Frontier
Deal found 3/17![Frontier logo]()
$346
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:35 am
STL
- RDU
1 stop4h 10m
Southwest
Tue 5/56:50 am
RDU
- STL
2 stops9h 00m
Southwest
Deal found 3/16![Southwest logo]()
$322
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:10 pm
STL
- RDU
Nonstop1h 50m
Southwest
Mon 4/206:25 am
RDU
- STL
Nonstop2h 10m
Southwest
Deal found 3/13![Southwest logo]()
$327
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:30 am
STL
- RDU
2 stops6h 36m
United Airlines
Tue 5/53:02 pm
RDU
- STL
2 stops7h 11m
United Airlines
Deal found 3/16![United Airlines logo]()
$385
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:35 am
STL
- RDU
1 stop6h 45m
Southwest
Tue 5/56:45 pm
RDU
- STL
Nonstop2h 15m
Southwest
Deal found 3/14![Southwest logo]()
$327
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:40 pm
STL
- RDU
1 stop4h 05m
Southwest
Tue 6/26:50 am
RDU
- STL
2 stops7h 00m
Southwest
Deal found 3/13![Southwest logo]()
$369
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2910:25 am
STL
- RDU
Nonstop1h 50m
Southwest
Thu 6/47:55 pm
RDU
- STL
Nonstop2h 05m
Southwest
Deal found 3/15![Southwest logo]()
$392
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:45 pm
STL
- RDU
1 stop3h 50m
Southwest
Tue 3/3110:15 am
RDU
- STL
2 stops8h 45m
Southwest
Deal found 3/14![Southwest logo]()
$396
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/97:35 am
STL
- RDU
1 stop3h 35m
Southwest
Thu 4/94:50 pm
RDU
- STL
2 stops7h 25m
Southwest
Deal found 3/15![Southwest logo]()
$396
Last-minute flights from St. Louis to DurhamDiscover last-minute flight deals from St. Louis to Durham. Data last updated March 18, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Durham. Data last updated March 18, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:47 am
STL
- RDU
1 stop6h 49m
Frontier
Thu 4/306:10 am
RDU
- STL
1 stop5h 16m
Frontier
Deal found 3/16![Frontier logo]()
$215
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:19 pm
STL
- RDU
1 stop20h 43m
Frontier
Tue 4/147:37 pm
RDU
- STL
1 stop28h 42m
Frontier
Deal found 3/15![Frontier logo]()
$180
This CheapOair deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/144:59 pm
STL
- RDU
1 stop16h 00m
Frontier
Fri 4/178:43 pm
RDU
- STL
1 stop27h 36m
Frontier
Deal found 3/17![Frontier logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:25 am
STL
- RDU
1 stop10h 30m
Frontier
Sun 4/196:10 am
RDU
- STL
1 stop25h 40m
Frontier
Deal found 3/15![Frontier logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:23 pm
STL
- RDU
1 stop11h 43m
Frontier
Wed 4/224:00 pm
RDU
- STL
1 stop19h 30m
Frontier
Deal found 3/15![Frontier logo]()
$166
This Gotogate deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/204:59 pm
STL
- RDU
1 stop22h 57m
Frontier
Tue 4/217:37 pm
RDU
- STL
1 stop28h 42m
Frontier
Deal found 3/15![Frontier logo]()
$189
This CheapOair deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/214:59 pm
STL
- RDU
1 stop16h 00m
Frontier
Sun 4/269:49 pm
RDU
- STL
1 stop22h 43m
Frontier
Deal found 3/17![Frontier logo]()
$212
This Mytrip deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/284:59 pm
STL
- RDU
1 stop16h 00m
Frontier
Tue 5/512:54 pm
RDU
- STL
1 stop5h 42m
Frontier
Deal found 3/14![Frontier logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:21 am
STL
- RDU
1 stop10h 59m
Frontier
Thu 5/712:54 pm
RDU
- STL
1 stop5h 00m
Frontier
Deal found 3/16![Frontier logo]()
$184
This Frontier deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:21 am
STL
- RDU
1 stop10h 59m
Frontier
Sat 5/211:53 am
RDU
- STL
1 stop12h 26m
Frontier
Deal found 3/15![Frontier logo]()
$201
One-way flights from St. Louis to DurhamSearch for one-way flight options from St. Louis to Durham. Find affordable one-way fares based on user searches. Data last updated March 18, 2026.
Search for one-way flight options from St. Louis to Durham. Find affordable one-way fares based on user searches. Data last updated March 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/158:23 pm
STL
- RDU
1 stop11h 00m
Frontier
Deal found 3/17![Frontier logo]()
$70
This Trip.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:25 am
STL
- RDU
1 stop10h 30m
Frontier
Deal found 3/17![Frontier logo]()
$77
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:23 pm
STL
- RDU
1 stop11h 43m
Frontier
Deal found 3/17![Frontier logo]()
$82
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:27 pm
STL
- RDU
1 stop13h 37m
Frontier
Deal found 3/17![Frontier logo]()
$88
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:29 pm
STL
- RDU
1 stop13h 17m
Frontier
Deal found 3/13![Frontier logo]()
$89
This Frontier deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:27 pm
STL
- RDU
1 stop6h 06m
Frontier
Deal found 3/17![Frontier logo]()
$90
This Expedia deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:19 pm
STL
- RDU
1 stop20h 43m
Frontier
Deal found 3/14![Frontier logo]()
$96
This CheapOair deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/144:59 pm
STL
- RDU
1 stop16h 00m
Frontier
Deal found 3/16![Frontier logo]()
$102
Find flight deals from St. Louis to Durham
Keep the following information in mind while searching for St. Louis to Durham flight deals. Data was last updated March 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $163 (Kiwi.com) |
One-way from | $70 (Kiwi.com) |
Popular in | August |
Cheapest in | October |
Average price | $423 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 18, 2026.
Use the filters below to find and compare flights from St. Louis to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Mon 4/13
7:45 pm-10:35 pm
Nonstop1h 50m
Raleigh-Durham
Wed 4/15
6:45 pm-8:00 pm
Nonstop2h 15m
$317
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Wed 4/8
7:35 am-12:45 pm
1 stop4h 10m
Raleigh-Durham
Tue 5/5
6:50 am-2:50 pm
2 stops9h 00m
$322
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Sat 4/18
5:10 pm-8:00 pm
Nonstop1h 50m
Raleigh-Durham
Mon 4/20
6:25 am-7:35 am
Nonstop2h 10m
$327
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Tue 4/28
8:35 am-4:20 pm
1 stop6h 45m
Raleigh-Durham
Tue 5/5
6:45 pm-8:00 pm
Nonstop2h 15m
$327
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Fri 4/3
6:30 am-2:06 pm
2 stops6h 36m
Raleigh-Durham
Sun 4/5
6:00 am-10:28 am
1 stop5h 28m
$344
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Thu 4/2
4:54 pm-7:56 am
1 stop14h 02m
Raleigh-Durham
Sun 4/5
6:00 am-10:30 am
1 stop5h 30m
$346
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Fri 5/29
4:40 pm-9:45 pm
1 stop4h 05m
Raleigh-Durham
Tue 6/2
6:50 am-12:50 pm
2 stops7h 00m
$369
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Wed 4/8
6:30 am-2:06 pm
2 stops6h 36m
Raleigh-Durham
Tue 5/5
3:02 pm-9:13 pm
2 stops7h 11m
$385
Quickest round-trip
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Fri 5/29
10:25 am-1:15 pm
Nonstop1h 50m
Raleigh-Durham
Thu 6/4
7:55 pm-9:00 pm
Nonstop2h 05m
$392
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
Mon 3/23
4:45 pm-9:35 pm
1 stop3h 50m
Raleigh-Durham
Tue 3/31
10:15 am-6:00 pm
2 stops8h 45m
$396
Showing 1-10 of 23 resultsSorted by cheapest first
Best time to book a flight from St. Louis to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from St. Louis with our price prediction graph.
STL-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Durham
STL-DU8
STL-RDU
How far ahead should I book a flight from St. Louis to Durham?
Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Durham. Price data was last updated on March 13, 2026.
The best time to book flights from St. Louis to Durham is 58 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from St. Louis to Durham?
Currently, December is the cheapest month in which you can book a flight from St. Louis to Durham (average of $135). Flying from St. Louis to Durham in March is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to DU8?
Find hourly flight availability from St. Louis to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 18, 2026.
It’s optimal to fly from St. Louis to Durham in the evening. By choosing this option you can save up to 62% on the cost of your flight, compared to a flight at noon.
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated March 18, 2026.
See what other customers who have flown with Southwest,Delta, andAmerican Airlines from St. Louis to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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St. Louis and Durham flights
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Top 4 airlines flying from St. Louis to Durham
Discover the top 4 airlines that operate flights from St. Louis to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$134 | Average$200 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$196 | Average$361 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$196 | Average$401 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$257 | Average$406 | FlexibilityNo cancel fee | On-time63% |