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Durham

$57+ Cheap flights from St. Louis (STL) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — RDU
Nov 22 — Nov 291
Sat 11/22
Sat 11/29
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Durham are usually found in September or November, booked 49 days in advance, depart on a Monday or Wednesday and return on a Wednesday

Cheap flight deals from St. Louis to Durham

Keep the following information in mind while searching for St. Louis to Durham flight deals. Data was last updated October 23, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$149
(American Airlines)

One-way from

$57
(Kiwi.com)

Popular in

August

Cheapest in

September

Average price

$364
Provider with most accurate pricing for Lambert-St Louis-Raleigh-Durham flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Raleigh-Durham flights.
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From Lambert-St Louis to Durham
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One-way flight from Lambert-St Louis to Durham
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Highest demand for flights based on searches. 11% potential increase in price ($50 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from St. Louis to Durham

Cheapest flights from St. Louis to Durham
Explore the most affordable flight options available from St. Louis to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:02 amSTL - RDU
1 stop4h 30mAmerican Airlines
Sat 12/133:01 pmRDU - STL
1 stop5h 29mAmerican Airlines
Deal found 10/21$149
This Frontier deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1311:07 amSTL - RDU
1 stop5h 55mFrontier
Thu 11/206:00 amRDU - STL
1 stop9h 29mFrontier
Deal found 10/22$150
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:58 pmSTL - RDU
1 stop4h 04mAmerican Airlines
Tue 12/93:39 pmRDU - STL
1 stop4h 04mAmerican Airlines
Deal found 10/21$159
This Booking.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/157:45 pmSTL - RDU
1 stop19h 51mFrontier
Thu 11/209:19 amRDU - STL
1 stop15h 38mFrontier
Deal found 10/23$160
This Priceline deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/212:20 pmSTL - RDU
1 stop10h 35mFrontier
Sat 11/810:45 amRDU - STL
1 stop5h 53mFrontier
Deal found 10/22$163
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:13 amSTL - RDU
1 stop5h 35mAmerican Airlines
Mon 12/84:22 pmRDU - STL
1 stop5h 16mAmerican Airlines
Deal found 10/23$172
This Booking.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/14:33 pmSTL - RDU
1 stop16h 10mFrontier
Sat 11/810:45 amRDU - STL
1 stop5h 53mFrontier
Deal found 10/23$173
This Priceline deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/314:52 pmSTL - RDU
1 stop5h 13mFrontier
Sun 11/25:00 amRDU - STL
1 stop6h 09mFrontier
Deal found 10/22$176
This Frontier deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1311:07 amSTL - RDU
1 stop10h 51mFrontier
Sun 11/166:00 amRDU - STL
1 stop12h 22mFrontier
Deal found 10/21$179
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1311:07 amSTL - RDU
1 stop5h 55mFrontier
Wed 11/196:10 amRDU - STL
1 stop17h 51mFrontier
Deal found 10/22$181
This Mytrip deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/611:07 amSTL - RDU
1 stop5h 55mFrontier
Mon 11/105:21 pmRDU - STL
1 stop16h 46mFrontier
Deal found 10/23$188
This Booking.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:45 pmSTL - RDU
1 stop19h 51mFrontier
Mon 11/175:21 pmRDU - STL
1 stop16h 46mFrontier
Deal found 10/23$191

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
Use the filters below to find and compare flights from St. Louis to Durham that are best for you.

Fly from

St. Louis

Fly to

Durham

Route

Depart

Return

Price

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Fri 12/5

5:58 pm-11:02 pm

1 stop4h 04m

Raleigh-Durham

Tue 12/9

3:39 pm-6:43 pm

1 stop4h 04m

$159

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Fri 12/5

10:42 am-12:12 am

1 stop12h 30m

Raleigh-Durham

Mon 12/8

6:10 am-10:33 pm

2 stops17h 23m

$210

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Fri 11/14

4:56 pm-8:24 am

2 stops14h 28m

Raleigh-Durham

Sun 11/16

9:35 pm-9:40 am

1 stop13h 05m

$243

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Tue 11/18

6:09 pm-11:15 pm

1 stop4h 06m

Raleigh-Durham

Thu 11/20

5:30 am-9:46 am

1 stop5h 16m

$249

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Wed 12/10

7:43 pm-11:49 am

2 stops15h 06m

Raleigh-Durham

Fri 12/12

6:26 pm-10:14 am

1 stop16h 48m

$251

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Sat 11/15

7:45 pm-10:48 pm

2 stops26h 03m

Raleigh-Durham

Thu 11/20

6:00 am-2:29 pm

1 stop9h 29m

$262

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Thu 1/1

10:42 am-12:13 am

1 stop12h 31m

Raleigh-Durham

Mon 1/5

9:47 pm-10:33 pm

2 stops25h 46m

$284

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Thu 11/20

3:14 pm-11:32 pm

1 stop7h 18m

Raleigh-Durham

Thu 11/27

3:58 pm-3:08 pm

2 stops24h 10m

$295

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Fri 12/5

6:10 pm-8:55 pm

Nonstop1h 45m

Raleigh-Durham

Tue 12/9

6:15 pm-7:30 pm

Nonstop2h 15m

$328

St. LouisRaleigh

STL - RDU

STLRDU

Lambert-St Louis

Mon 11/24

4:13 pm-8:47 am

1 stop15h 34m

Raleigh-Durham

Thu 11/27

6:00 am-2:29 pm

1 stop9h 29m

$328

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/21

Showing 1-10 of 22 results
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Best time to book a flight from St. Louis to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Durham

How far ahead should I book a flight from St. Louis to Durham?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Durham. Price data was last updated on October 17, 2025.

The best time to book flights from St. Louis to Durham is 49 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from St. Louis to Durham?

Currently, October is the cheapest month in which you can book a flight from St. Louis to Durham (average of $144). Flying from St. Louis to Durham in December is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to DU8?

Find hourly flight availability from St. Louis to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 23, 2025.

It’s optimal to fly from St. Louis to Durham in the evening. By choosing this option you can save up to 37% on the cost of your flight, compared to a flight at noon.

What is the cheapest day to fly from St. Louis to Durham?

Use this chart to determine the cheapest time to fly round-trip from St. Louis to Durham. Price data was last updated on November 3, 2024.

Travelers seeking maximum savings on their St. Louis to Durham flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated October 23, 2025.
See what other customers who have flown with Southwest, Delta, and American Airlines from St. Louis to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,237 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,237 reviews
Southwest
8.0
Very good
4,237 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,981 reviews
Southwest
8.0
Very good
4,237 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,028 reviews
Southwest
8.0
Very good
4,237 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Frontier
5.8
Fair
3,128 reviews
Southwest
8.0
Very good
4,237 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to Durham?

    Lambert-St Louis (STL), located 12.7 mi from the city center, is the airport you fly out of when you book flights from St. Louis to Durham. 4 airlines have flights from Lambert-St Louis to Durham on a regular basis. Booking flights from Lambert-St Louis to Durham should not be difficult; the airport handles an average of 1 outbound flight to Durham per day.

  • How popular is this St. Louis to Durham flight route?

    Within the past month, 4 users have taken a look at flights from Lambert-St Louis to Durham.

  • How long is the flight from St. Louis to Durham?

    There are many flights that can get you from St. Louis to Durham in 4h 04m. Fly via American Airlines, Frontier, or Delta to get the fastest option. The distance from St. Louis to Durham is about 666 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest flights from St. Louis to Durham?

    Looking for the cheapest flight from St. Louis to Durham? While on average our users pay $286, our data indicates the cheapest price to be $168. The most popular route (Lambert-St Louis - Raleigh-Durham), is priced around $177.

  • Can I find deals for flights from St. Louis to Durham that include hotel bookings?

    Yes. In addition to deals on St. Louis to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Durham.

  • Can I find deals for business class flights from St. Louis to Durham?

    Yes. Cheapflights offers flight deals from St. Louis to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Durham?

    Currently, October is the cheapest month in which you can book a flight from St. Louis to Durham (average of $144). Flying from St. Louis to Durham in December is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from St. Louis to Durham

Discover the top 4 airlines that operate flights from St. Louis to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$118Average$178FlexibilityNo cancel feeOn-time62%
DeltaCheapest$218Average$369FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$236Average$386FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$240Average$380FlexibilityNo cancel feeOn-time63%

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