$59+ Cheap flights from St. Louis (STL) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — RDU
feb. 28 — mar. 71
1 adult, Economy
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Find cheap flights from St. Louis to Durham with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Lambert-St Louis to Durham are usually found in October or September, booked 58 days in advance, depart on a Monday or Wednesday and return on a Wednesday
Cheap flight deals from St. Louis to Durham
Cheapest flights from St. Louis to DurhamExplore the most affordable flight options available from St. Louis to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 29, 2026.
Explore the most affordable flight options available from St. Louis to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/253:49 pm
STL
- RDU
1 stop15h 03m
Frontier
mié. 3/42:53 pm
RDU
- STL
1 stop8h 34m
Frontier
Deal found 1/28![Frontier logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/188:17 pm
STL
- RDU
1 stop20h 38m
Frontier
dom. 2/224:30 pm
RDU
- STL
1 stop15h 21m
Frontier
Deal found 1/29![Frontier logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/203:49 pm
STL
- RDU
1 stop17h 39m
Frontier
dom. 2/224:30 pm
RDU
- STL
1 stop15h 21m
Frontier
Deal found 1/27![Frontier logo]()
$132
This CheapOair deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/253:49 pm
STL
- RDU
1 stop17h 04m
Frontier
mar. 3/35:54 pm
RDU
- STL
1 stop5h 33m
Frontier
Deal found 1/28![Frontier logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/45:42 pm
STL
- RDU
1 stop20h 58m
Frontier
dom. 2/86:10 am
RDU
- STL
1 stop25h 41m
Frontier
Deal found 1/28![Frontier logo]()
$142
This CheapOair deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/183:49 pm
STL
- RDU
1 stop15h 03m
Frontier
lun. 2/234:04 pm
RDU
- STL
1 stop8h 55m
Frontier
Deal found 1/28![Frontier logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/253:49 pm
STL
- RDU
1 stop15h 03m
Multiple Airlines
mar. 3/36:08 pm
RDU
- STL
2 stops13h 43m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$154
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/273:49 pm
STL
- RDU
1 stop15h 03m
Frontier
dom. 3/14:30 pm
RDU
- STL
1 stop15h 21m
Frontier
Deal found 1/27![Frontier logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/183:49 pm
STL
- RDU
1 stop15h 03m
Multiple Airlines
lun. 2/236:08 pm
RDU
- STL
2 stops37h 43m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$156
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/188:17 pm
STL
- RDU
2 stops19h 54m
Multiple Airlines
dom. 2/224:30 pm
RDU
- STL
1 stop15h 21m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/55:42 pm
STL
- RDU
1 stop20h 58m
Frontier
lun. 2/99:56 pm
RDU
- STL
1 stop25h 31m
Frontier
Deal found 1/26![Frontier logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/35:42 pm
STL
- RDU
1 stop21h 48m
Frontier
mié. 2/186:14 pm
RDU
- STL
2 stops37h 37m
Frontier
Deal found 1/26![Frontier logo]()
$172
Find flight deals from St. Louis to Durham
Keep the following information in mind while searching for St. Louis to Durham flight deals. Data was last updated enero 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $128 (Kiwi.com) |
One-way from | $59 (Trip.com) |
Popular in | August |
Cheapest in | October |
Average price | $371 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 29, 2026.
Use the filters below to find and compare flights from St. Louis to Durham that are best for you.
Fly from
St. Louis
Fly to
Durham
Route
Depart
Return
Price
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
mié. 2/25
3:49 pm-7:52 am
1 stop15h 03m
Raleigh-Durham
mié. 3/4
2:53 pm-10:27 pm
1 stop8h 34m
$128
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
mié. 2/18
8:17 pm-5:55 pm
1 stop20h 38m
Raleigh-Durham
dom. 2/22
4:30 pm-6:51 am
1 stop15h 21m
$131
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
vie. 2/20
3:49 pm-10:28 am
1 stop17h 39m
Raleigh-Durham
dom. 2/22
4:30 pm-6:51 am
1 stop15h 21m
$132
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
mié. 2/25
3:49 pm-9:53 am
1 stop17h 04m
Raleigh-Durham
mar. 3/3
5:54 pm-10:27 pm
1 stop5h 33m
$139
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
mié. 2/25
8:17 pm-5:11 pm
2 stops19h 54m
Raleigh-Durham
mié. 3/4
2:53 pm-10:27 pm
1 stop8h 34m
$162
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
vie. 2/27
8:22 pm-10:03 am
2 stops12h 41m
Raleigh-Durham
dom. 3/1
4:30 pm-6:51 am
1 stop15h 21m
$198
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
lun. 5/4
8:12 pm-5:05 pm
1 stop19h 53m
Raleigh-Durham
vie. 5/8
6:50 pm-11:19 pm
1 stop5h 29m
$206
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
lun. 3/30
7:47 am-3:36 pm
1 stop6h 49m
Raleigh-Durham
jue. 4/30
6:00 am-10:30 am
1 stop5h 30m
$210
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
vie. 4/17
8:12 pm-9:04 pm
1 stop23h 52m
Raleigh-Durham
lun. 4/20
1:22 pm-11:19 pm
1 stop10h 57m
$247
St. LouisRaleigh
STL - RDU
STLRDU
Lambert-St Louis
sáb. 3/28
8:12 pm-8:27 am
2 stops11h 15m
Raleigh-Durham
lun. 3/30
4:06 pm-10:32 am
1 stop19h 26m
$261
Showing 1-10 of 23 results
Best time to book a flight from St. Louis to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Durham
How far ahead should I book a flight from St. Louis to Durham?
Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Durham. Price data was last updated on January 23, 2026.
The best time to book flights from St. Louis to Durham is 58 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from St. Louis to Durham?
Currently, December is the cheapest month in which you can book a flight from St. Louis to Durham (average of $135). Flying from St. Louis to Durham in May is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to DU8?
Find hourly flight availability from St. Louis to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated enero 29, 2026.
It’s optimal to fly from St. Louis to Durham in the evening. By choosing this option you can save up to 77% on the cost of your flight, compared to a flight at noon.
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated enero 29, 2026.
See what other customers who have flown with Southwest, Delta, and American Airlines from St. Louis to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for St. Louis to Durham
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from St. Louis to Durham
Discover the top 4 airlines that operate flights from St. Louis to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$132 | Average$200 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$138 | Average$361 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$236 | Average$390 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$257 | Average$402 | FlexibilityNo cancel fee | On-time63% |