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$70+ Cheap flights from Des Moines (DSM) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — RDU
feb. 28 — mar. 71
sáb. 2/28
sáb. 3/7
1 adult, Economy
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Cheap flight deals from Des Moines to Durham

Cheapest flights from Des Moines to Durham
Explore the most affordable flight options available from Des Moines to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 29, 2026.

This Frontier deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/57:27 pm
DSM
-
RDU
1 stop21h 21m
Frontier
mié. 3/118:47 am
RDU
-
DSM
1 stop25h 58m
Frontier
Deal found 1/28$196
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/57:27 pm
DSM
-
RDU
1 stop21h 21m
Multiple Airlines
mié. 3/114:12 pm
RDU
-
DSM
2 stops29h 02m
Multiple Airlines
Deal found 1/28$231
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/246:10 am
DSM
-
RDU
1 stop3h 55m
Southwest
mar. 3/35:35 pm
RDU
-
DSM
1 stop4h 35m
Southwest
Deal found 1/27$271
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/57:27 pm
DSM
-
RDU
2 stops13h 11m
Frontier
dom. 3/810:07 pm
RDU
-
DSM
1 stop22h 09m
Frontier
Deal found 1/27$278
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 3/44:20 pm
DSM
-
RDU
1 stop6h 29m
Delta
lun. 3/96:15 am
RDU
-
DSM
1 stop5h 33m
Delta
Deal found 1/28$290
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/55:35 am
DSM
-
RDU
2 stops6h 30m
Southwest
mié. 3/1112:00 pm
RDU
-
DSM
2 stops9h 50m
Southwest
Deal found 1/28$300
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/197:45 am
DSM
-
RDU
1 stop5h 26m
American Airlines
lun. 2/235:00 am
RDU
-
DSM
1 stop5h 01m
American Airlines
Deal found 1/27$309
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/286:59 pm
DSM
-
RDU
1 stop4h 31m
United Airlines
dom. 5/36:20 am
RDU
-
DSM
1 stop5h 17m
United Airlines
Deal found 1/29$329

Find flight deals from Des Moines to Durham

Keep the following information in mind while searching for Des Moines to Durham flight deals. Data was last updated enero 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$196
(Frontier)

One-way from

$70
(Trip.com)

Popular in

January

Cheapest in

September

Average price

$549
Provider with most accurate pricing for Des Moines-Raleigh-Durham flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Raleigh-Durham flights.
Search Deals
From Des Moines to Durham
Search Deals
One-way flight from Des Moines to Durham
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($74 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 29, 2026.
Use the filters below to find and compare flights from Des Moines to Durham that are best for you.

Fly from

Des Moines

Fly to

Durham

Route

Depart

Return

Price

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

jue. 3/5

7:27 pm-5:48 pm

1 stop21h 21m

Raleigh-Durham

mié. 3/11

4:12 pm-8:14 pm

2 stops29h 02m

$231

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

mar. 2/24

7:52 am-3:40 pm

1 stop6h 48m

Raleigh-Durham

mar. 3/3

5:14 pm-9:41 pm

1 stop5h 27m

$271

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

mar. 2/24

6:10 am-11:05 am

1 stop3h 55m

Raleigh-Durham

mar. 3/3

5:35 pm-9:10 pm

1 stop4h 35m

$271

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

jue. 3/5

7:27 pm-9:38 am

2 stops13h 11m

Raleigh-Durham

dom. 3/8

10:07 pm-7:16 pm

1 stop22h 09m

$278

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

jue. 3/5

5:35 am-1:05 pm

2 stops6h 30m

Raleigh-Durham

mié. 3/11

12:00 pm-8:50 pm

2 stops9h 50m

$300

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

jue. 2/19

7:45 am-2:11 pm

1 stop5h 26m

Raleigh-Durham

lun. 2/23

5:00 am-9:01 am

1 stop5h 01m

$309

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

mié. 4/29

5:45 pm-11:39 pm

1 stop4h 54m

Raleigh-Durham

dom. 5/3

6:20 am-11:05 am

1 stop5h 45m

$329

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

mar. 4/28

6:59 pm-12:30 am

1 stop4h 31m

Raleigh-Durham

dom. 5/3

6:20 am-10:37 am

1 stop5h 17m

$329

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

mar. 4/28

11:51 am-5:04 pm

1 stop4h 13m

Raleigh-Durham

dom. 5/3

6:00 am-10:18 am

1 stop5h 18m

$329

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

mié. 5/20

11:40 am-5:23 pm

1 stop4h 43m

$136

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 19 results
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Best time to book a flight from Des Moines to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Durham

What is the cheapest month to book a flight from Des Moines to Durham?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Durham (average of $184). Flying from Des Moines to Durham in December is currently the most expensive (average of $346). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated enero 29, 2026.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Des Moines to Durham by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,267 reviews
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,128 reviews
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,215 reviews
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,205 reviews
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Durham?

    For a flight from Des Moines to Durham, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 0 outbound flights to Durham per day. 4 airlines have flights to Durham from Des Moines on a regular basis.

  • How long is the flight from Des Moines to Durham?

    Departing from Des Moines to Durham will take you 3h 55m. The distance between Des Moines and Durham is about 890 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Des Moines to Durham one-way?

    For one-way options, check prices for Southwest. According to our data, you can fly for as low as $135. Users have also found prices from $135 and $148 on American Airlines and United Airlines, respectively.

  • Can I find deals for flights from Des Moines to Durham that include hotel bookings?

    Yes. In addition to deals on Des Moines to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Durham.

  • Can I find deals for business class flights from Des Moines to Durham?

    Yes. Cheapflights offers flight deals from Des Moines to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Durham?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Durham (average of $184). Flying from Des Moines to Durham in December is currently the most expensive (average of $346). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Des Moines to Durham

Discover the top 4 airlines that operate flights from Des Moines to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$216Average$386FlexibilityNo cancel feeOn-time63%
DeltaCheapest$236Average$315FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$390FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$276Average$349FlexibilityNo cancel feeOn-time69%

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