HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Durham

$85+ Cheap flights from Des Moines (DSM) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — RDU
Nov 26 — Dec 31
Wed 11/26
Wed 12/3
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Durham with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Des Moines to Durham are usually found in September or May, booked 30 days in advance, depart on a Wednesday or Tuesday and return on a Friday

Cheap flight deals from Des Moines to Durham

Keep the following information in mind while searching for Des Moines to Durham flight deals. Data was last updated October 27, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$201
(Booking.com)

One-way from

$85
(Mytrip)

Popular in

June

Cheapest in

September

Average price

$366
Provider with most accurate pricing for Des Moines-Raleigh-Durham flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Raleigh-Durham flights.
Search Deals
From Des Moines to Durham
Search Deals
One-way flight from Des Moines to Durham
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($7 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Find flight deals from Des Moines to Durham

Cheapest flights from Des Moines to Durham
Explore the most affordable flight options available from Des Moines to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.

This Booking.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/132:41 pmDSM - RDU
1 stop24h 55mFrontier
Sun 11/165:21 pmRDU - DSM
1 stop21h 26mFrontier
Deal found 10/25$201
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/97:30 amDSM - RDU
1 stop10h 42mMultiple Airlines
Thu 11/138:27 pmRDU - DSM
1 stop19h 28mMultiple Airlines
Deal found 10/25$238
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:28 pmDSM - RDU
2 stops15h 24mMultiple Airlines
Mon 12/152:14 pmRDU - DSM
1 stop7h 55mMultiple Airlines
Deal found 10/26$248
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/132:41 pmDSM - RDU
2 stops15h 55mMultiple Airlines
Sun 11/169:06 amRDU - DSM
1 stop5h 55mMultiple Airlines
Deal found 10/25$274
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:56 pmDSM - RDU
1 stop24h 59mMultiple Airlines
Mon 12/86:10 amRDU - DSM
2 stops16h 03mMultiple Airlines
Deal found 10/26$275
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/78:40 amDSM - RDU
1 stop27h 39mMultiple Airlines
Sun 11/99:06 amRDU - DSM
1 stop5h 55mMultiple Airlines
Deal found 10/26$304
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/101:17 pmDSM - RDU
1 stop6h 03mAmerican Airlines
Wed 12/176:09 amRDU - DSM
1 stop7h 14mAmerican Airlines
Deal found 10/26$312

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 27, 2025.
Use the filters below to find and compare flights from Des Moines to Durham that are best for you.

Fly from

Des Moines

Fly to

Durham

Route

Depart

Return

Price

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Sun 11/9

7:30 am-7:12 pm

1 stop10h 42m

Raleigh-Durham

Thu 11/13

8:27 pm-2:55 pm

1 stop19h 28m

$238

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Wed 12/10

3:18 pm-8:48 pm

1 stop4h 30m

Raleigh-Durham

Wed 12/17

7:00 am-11:42 am

1 stop5h 42m

$312

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Tue 12/9

11:23 am-7:16 pm

1 stop6h 53m

Raleigh-Durham

Tue 12/16

10:02 am-1:31 pm

1 stop4h 29m

$313

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Tue 11/25

5:26 pm-12:39 am

1 stop6h 13m

Raleigh-Durham

Wed 11/26

6:33 pm-12:21 am

1 stop6h 48m

$317

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Fri 12/12

5:43 pm-11:17 pm

1 stop4h 34m

Raleigh-Durham

Mon 12/15

9:57 am-4:16 pm

1 stop7h 19m

$350

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Tue 11/25

5:41 am-12:31 pm

1 stop5h 50m

Raleigh-Durham

Fri 11/28

9:11 am-1:29 pm

1 stop5h 18m

$352

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Tue 3/3

5:45 am-11:18 am

1 stop4h 33m

Raleigh-Durham

Thu 3/5

5:45 am-9:30 am

1 stop4h 45m

$352

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Tue 12/30

6:40 am-1:30 pm

1 stop5h 50m

Raleigh-Durham

Thu 1/1

8:17 pm-12:37 am

1 stop5h 20m

$355

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Fri 12/12

3:17 pm-11:44 pm

2 stops7h 27m

Raleigh-Durham

Mon 12/15

3:05 pm-9:37 pm

2 stops7h 32m

$360

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Mon 11/17

2:32 pm-5:08 pm

2 stops25h 36m

$105

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/26

Showing 1-10 of 21 results
1
2
3

Best time to book a flight from Des Moines to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Durham

How far ahead should I book a flight from Des Moines to Durham?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Durham. Price data was last updated on October 24, 2025.

Booking 30 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Durham. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Des Moines to Durham?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Durham (average of $146). Flying from Des Moines to Durham in December is currently the most expensive (average of $327). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to DU8?

Find hourly flight availability from Des Moines to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 27, 2025.

A simple way to save on the total cost of your ticket is to fly from Des Moines to Durham in the evening. If you’re flexible enough to do this you can expect to save up to 70% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated October 27, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Des Moines to Durham by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,235 reviews

Food

7.0

Boarding

8.1

Overall

8.0

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,235 reviews
Southwest
8.0
Very good
4,235 reviews

Food

7.0

Boarding

8.1

Overall

8.0

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,997 reviews
Southwest
8.0
Very good
4,235 reviews

Food

7.0

Boarding

8.1

Overall

8.0

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,999 reviews
Southwest
8.0
Very good
4,235 reviews

Food

7.0

Boarding

8.1

Overall

8.0

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,030 reviews
Southwest
8.0
Very good
4,235 reviews

Food

7.0

Boarding

8.1

Overall

8.0

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Durham?

    For a flight from Des Moines to Durham, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 0 outbound flights to Durham per day. 4 airlines have flights to Durham from Des Moines on a regular basis.

  • How long is the flight from Des Moines to Durham?

    Departing from Des Moines to Durham will take you 4h 30m. The distance between Des Moines and Durham is about 890 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Des Moines to Durham that include hotel bookings?

    Yes. In addition to deals on Des Moines to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Durham.

  • Can I find deals for business class flights from Des Moines to Durham?

    Yes. Cheapflights offers flight deals from Des Moines to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Durham?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Durham (average of $146). Flying from Des Moines to Durham in December is currently the most expensive (average of $327). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Durham

See prices for flight routes from nearby airports that may be better suited for you.
Moline to Charlotte flights
Cedar Rapids to Charlotte flights
Cedar Rapids to Knoxville flights
Omaha to Charlotte flights
Des Moines to Charlotte flights
Des Moines to Raleigh flights
Omaha to Raleigh flights
Cedar Rapids to Wilmington flights
Des Moines to Knoxville flights
Omaha to Knoxville flights
Des Moines to Norfolk flights
Moline to Norfolk flights
Moline to Raleigh flights
Cedar Rapids to Raleigh flights
Omaha to Norfolk flights
Omaha to Asheville flights
Cedar Rapids to Asheville flights
Cedar Rapids to Norfolk flights
Cedar Rapids to Greensboro flights
Moline to Myrtle Beach flights
Omaha to Wilmington flights
Des Moines to Asheville flights
Moline to Knoxville flights
Des Moines to Myrtle Beach flights
Moline to Wilmington flights
Cedar Rapids to Myrtle Beach flights
Omaha to Fayetteville flights
Des Moines to Wilmington flights
Omaha to Myrtle Beach flights
Des Moines to Greensboro flights
Omaha to Greensboro flights
Cedar Rapids to Blountville flights
Des Moines to Blountville flights
Moline to Jacksonville flights
Cedar Rapids to Jacksonville flights
Moline to Greensboro flights
Moline to Asheville flights
Moline to Fayetteville flights
Omaha to Blountville flights
Waterloo to Raleigh flights
Sioux City to Raleigh flights
La Crosse to Raleigh flights
Waterloo to Charlotte flights
Des Moines to Jacksonville flights
Sioux City to Charlotte flights
Omaha to Jacksonville flights
Moline to New Bern flights
Des Moines to Fayetteville flights
Omaha to Greenville flights

Top 4 airlines flying from Des Moines to Durham

Discover the top 4 airlines that operate flights from Des Moines to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$216Average$426FlexibilityNo cancel feeOn-time63%
DeltaCheapest$236Average$307FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$393FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$276Average$386FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.