HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Durham

$87+ Cheap flights from Des Moines (DSM) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/23. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — RDU
ene. 11 — ene. 181
dom. 1/11
dom. 1/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Durham with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Des Moines to Durham are usually found in September or October, booked 30 days in advance, depart on a Wednesday or Tuesday and return on a Friday

Cheap flight deals from Des Moines to Durham

Cheapest flights from Des Moines to Durham
Explore the most affordable flight options available from Des Moines to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 12, 2025.

This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/2412:56 pmDSM - RDU
1 stop5h 55mAmerican Airlines
vie. 1/26:37 amRDU - DSM
1 stop6h 49mAmerican Airlines
Deal found 12/10$357
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/233:45 pmDSM - RDU
1 stop24h 10mMultiple Airlines
mar. 1/64:20 pmRDU - DSM
2 stops48h 20mMultiple Airlines
Deal found 12/10$405
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/236:00 amDSM - RDU
1 stop10h 50mAmerican Airlines
mar. 1/67:35 pmRDU - DSM
1 stop4h 33mAmerican Airlines
Deal found 12/10$455
This Southwest deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/248:20 amDSM - RDU
1 stop6h 20mSouthwest
vie. 1/23:55 pmRDU - DSM
2 stops9h 10mSouthwest
Deal found 12/10$472
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/2511:15 amDSM - RDU
2 stops11h 31mUnited Airlines
lun. 12/296:31 amRDU - DSM
1 stop5h 19mUnited Airlines
Deal found 12/10$478
This Southwest deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/235:30 amDSM - RDU
2 stops11h 25mSouthwest
mar. 1/611:50 amRDU - DSM
2 stops10h 20mSouthwest
Deal found 12/10$540
This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/206:30 pmDSM - RDU
1 stop4h 27mDelta
dom. 1/45:30 amRDU - DSM
1 stop5h 19mDelta
Deal found 12/10$552
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/236:00 amDSM - RDU
1 stop10h 50mAmerican Airlines
mar. 12/306:37 pmRDU - DSM
1 stop7h 00mAmerican Airlines
Deal found 12/11$553
This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/2110:29 amDSM - RDU
1 stop5h 10mDelta
dom. 12/286:30 amRDU - DSM
1 stop5h 08mDelta
Deal found 12/10$582
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/201:24 pmDSM - RDU
1 stop6h 33mAmerican Airlines
dom. 1/48:17 pmRDU - DSM
1 stop5h 20mAmerican Airlines
Deal found 12/11$587

Find flight deals from Des Moines to Durham

Keep the following information in mind while searching for Des Moines to Durham flight deals. Data was last updated diciembre 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$237
(Kiwi.com)

One-way from

$87
(Expedia)

Popular in

December

Cheapest in

September

Average price

$427
Provider with most accurate pricing for Des Moines-Raleigh-Durham flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Raleigh-Durham flights.
Search Deals
From Des Moines to Durham
Search Deals
One-way flight from Des Moines to Durham
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($48 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
Use the filters below to find and compare flights from Des Moines to Durham that are best for you.

Fly from

Des Moines

Fly to

Durham

Route

Depart

Return

Price

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

dom. 1/25

2:58 pm-2:13 pm

1 stop22h 15m

Raleigh-Durham

dom. 2/1

6:10 am-9:21 pm

2 stops40h 11m

$287

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

mar. 1/6

3:35 pm-11:44 pm

2 stops7h 09m

Raleigh-Durham

jue. 1/8

6:18 am-2:22 pm

2 stops9h 04m

$300

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

lun. 1/12

4:21 pm-11:27 pm

1 stop6h 06m

Raleigh-Durham

jue. 1/15

6:00 am-10:19 am

1 stop5h 19m

$309

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

jue. 1/29

7:40 am-1:06 pm

1 stop4h 26m

Raleigh-Durham

lun. 2/2

5:56 pm-10:11 pm

1 stop5h 15m

$309

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

sáb. 1/24

6:24 am-12:03 pm

1 stop4h 39m

Raleigh-Durham

sáb. 1/31

8:21 am-12:15 pm

1 stop4h 54m

$309

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

sáb. 1/24

7:00 am-2:49 pm

2 stops6h 49m

Raleigh-Durham

sáb. 1/31

7:27 pm-11:42 pm

1 stop5h 15m

$314

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

mié. 12/24

12:56 pm-7:51 pm

1 stop5h 55m

Raleigh-Durham

vie. 1/2

6:37 am-12:26 pm

1 stop6h 49m

$357

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

mié. 1/7

6:14 pm-9:17 am

1 stop14h 03m

$92

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

jue. 2/12

7:32 pm-1:39 pm

1 stop17h 07m

$133

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

sáb. 2/14

7:00 am-3:20 pm

1 stop7h 20m

$135

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 18 results
1
2

Best time to book a flight from Des Moines to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Durham

How far ahead should I book a flight from Des Moines to Durham?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Durham. Price data was last updated on December 5, 2025.

Booking 30 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Durham. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Des Moines to Durham?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Durham (average of $146). Flying from Des Moines to Durham in December is currently the most expensive (average of $349). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to DU8?

Find hourly flight availability from Des Moines to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 12, 2025.

A simple way to save on the total cost of your ticket is to fly from Des Moines to Durham in the evening. If you’re flexible enough to do this you can expect to save up to 70% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated diciembre 12, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Des Moines to Durham by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,253 reviews

Boarding

8.1

Overall

7.9

Comfort

8.0

Crew

8.6

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
7.9
Good
4,253 reviews
Southwest
7.9
Good
4,253 reviews

Boarding

8.1

Overall

7.9

Comfort

8.0

Crew

8.6

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,008 reviews
Southwest
7.9
Good
4,253 reviews

Boarding

8.1

Overall

7.9

Comfort

8.0

Crew

8.6

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,095 reviews
Southwest
7.9
Good
4,253 reviews

Boarding

8.1

Overall

7.9

Comfort

8.0

Crew

8.6

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,050 reviews
Southwest
7.9
Good
4,253 reviews

Boarding

8.1

Overall

7.9

Comfort

8.0

Crew

8.6

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Durham?

    For a flight from Des Moines to Durham, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 0 outbound flights to Durham per day. 4 airlines have flights to Durham from Des Moines on a regular basis.

  • How long is the flight from Des Moines to Durham?

    Departing from Des Moines to Durham will take you 6h 06m. The distance between Des Moines and Durham is about 890 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Des Moines to Durham one-way?

    For one-way options, check prices for Southwest. According to our data, you can fly for as low as $135. Users have also found prices from $135 and $148 on American Airlines and United Airlines, respectively.

  • Can I find deals for flights from Des Moines to Durham that include hotel bookings?

    Yes. In addition to deals on Des Moines to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Durham.

  • Can I find deals for business class flights from Des Moines to Durham?

    Yes. Cheapflights offers flight deals from Des Moines to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Durham?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Durham (average of $146). Flying from Des Moines to Durham in December is currently the most expensive (average of $349). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Durham

See prices for flight routes from nearby airports that may be better suited for you.
Des Moines to Charlotte flights
Cedar Rapids to Charlotte flights
Moline to Charlotte flights
Omaha to Raleigh flights
Omaha to Charlotte flights
Des Moines to Knoxville flights
Des Moines to Raleigh flights
Moline to Raleigh flights
Cedar Rapids to Raleigh flights
Cedar Rapids to Knoxville flights
Moline to Myrtle Beach flights
Cedar Rapids to Myrtle Beach flights
Moline to Fayetteville flights
Des Moines to Greensboro flights
Des Moines to Norfolk flights
Omaha to Norfolk flights
Des Moines to Wilmington flights
Cedar Rapids to Wilmington flights
Omaha to Myrtle Beach flights
Omaha to Asheville flights
Des Moines to Asheville flights
Moline to Norfolk flights
Cedar Rapids to Asheville flights
Des Moines to Myrtle Beach flights
Omaha to Greensboro flights
Omaha to Knoxville flights
Moline to Wilmington flights
Omaha to Wilmington flights
Cedar Rapids to Norfolk flights
Moline to Knoxville flights
Cedar Rapids to Greensboro flights
Omaha to Jacksonville flights
Cedar Rapids to Jacksonville flights
Moline to Greensboro flights
Des Moines to Jacksonville flights
Omaha to Fayetteville flights
Cedar Rapids to Blountville flights
Moline to Asheville flights
Des Moines to Blountville flights
La Crosse to Charlotte flights
Sioux City to Charlotte flights
Sioux City to Greensboro flights
Sioux City to Raleigh flights
Sioux City to Knoxville flights
Omaha to Greenville flights
Moline to Jacksonville flights
Waterloo to Charlotte flights
Des Moines to Fayetteville flights
Waterloo to Raleigh flights

Top 4 airlines flying from Des Moines to Durham

Discover the top 4 airlines that operate flights from Des Moines to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$216Average$417FlexibilityNo cancel feeOn-time63%
DeltaCheapest$236Average$320FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$390FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$276Average$351FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.