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Des Moines

$81+ Cheap flights from Spartanburg, SC to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/9. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — DSM
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheapflights Tip: The best prices from Spartanburg to Des Moines are usually found in March or September, booked 65 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Cheap flight deals from Spartanburg to Des Moines

Cheapest flights from Spartanburg to Des Moines
Explore the most affordable flight options available from Spartanburg to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:00 amCLT - DSM
1 stop17h 10mMultiple Airlines
Mon 1/56:35 amDSM - CLT
1 stop27h 28mMultiple Airlines
Deal found 12/9$320
This American Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/102:52 pmCLT - DSM
Nonstop2h 43mAmerican Airlines
Tue 12/165:05 pmDSM - CLT
Nonstop2h 36mAmerican Airlines
Deal found 12/9$469
This Southwest deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:45 amCLT - DSM
2 stops6h 15mSouthwest
Mon 1/55:45 amDSM - CLT
2 stops11h 20mSouthwest
Deal found 12/9$474
This American Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3011:49 amCLT - DSM
Nonstop2h 32mAmerican Airlines
Mon 1/53:27 pmDSM - CLT
1 stop16h 43mAmerican Airlines
Deal found 12/9$475
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/105:28 pmCLT - DSM
1 stop5h 09mUnited Airlines
Tue 12/161:31 pmDSM - CLT
1 stop8h 25mUnited Airlines
Deal found 12/9$489
This Southwest deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/141:05 pmCLT - DSM
1 stop8h 55mSouthwest
Tue 12/166:15 amDSM - CLT
1 stop10h 25mSouthwest
Deal found 12/10$491
This Southwest deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:45 amCLT - DSM
2 stops6h 15mSouthwest
Sun 12/285:30 amDSM - CLT
2 stops13h 00mSouthwest
Deal found 12/10$529
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/229:38 pmCLT - DSM
1 stop26h 32mMultiple Airlines
Sun 12/287:30 pmDSM - CLT
1 stop13h 09mMultiple Airlines
Deal found 12/11$533

Find flight deals from Spartanburg to Des Moines

Keep the following information in mind while searching for Spartanburg to Des Moines flight deals. Data was last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$227
(Mytrip)

One-way from

$81
(Frontier)

Popular in

December

Cheapest in

March

Average price

$508
Provider with most accurate pricing for Charlotte Douglas-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charlotte Douglas-Des Moines flights.
Search Deals
From Spartanburg to Des Moines
Search Deals
One-way flight from Spartanburg to Des Moines
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($51 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Spartanburg to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Spartanburg to Des Moines that are best for you.

Fly from

Spartanburg

Fly to

Des Moines

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 1/8

1:24 pm-10:46 pm

1 stop10h 22m

Des Moines

Mon 1/12

11:09 am-10:55 am

2 stops22h 46m

$227

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 1/8

11:12 am-10:46 pm

2 stops12h 34m

Des Moines

Thu 1/15

4:30 pm-11:59 pm

2 stops30h 29m

$326

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Tue 12/30

7:00 am-11:10 pm

1 stop17h 10m

Des Moines

Mon 1/5

8:00 am-3:37 pm

2 stops54h 37m

$331

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Mon 1/19

5:05 pm-10:15 pm

1 stop6h 10m

Des Moines

Sat 1/24

5:45 am-2:45 pm

1 stop8h 00m

$387

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Sun 1/18

8:25 am-11:25 am

1 stop4h 00m

Des Moines

Sat 1/31

5:45 am-2:45 pm

1 stop8h 00m

$390

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 1/8

11:05 am-7:20 pm

2 stops9h 15m

Des Moines

Mon 1/12

6:10 am-4:20 pm

2 stops9h 10m

$397

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 1/1

4:33 pm-11:30 pm

1 stop7h 57m

Des Moines

Mon 1/5

6:52 pm-9:10 am

1 stop13h 18m

$399

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Mon 3/9

12:17 pm-6:46 pm

1 stop7h 29m

$81

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 3/11

9:08 am-9:45 am

1 stop25h 37m

$115

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 1/7

9:38 pm-10:09 pm

2 stops25h 31m

$129

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 17 results
1
2

Best time to book a flight from Spartanburg to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Des Moines

How far ahead should I book a flight from Spartanburg to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from Spartanburg to Des Moines. Price data was last updated on December 5, 2025.

To ensure you get the cheapest price possible for a flight from Spartanburg to Des Moines, you should look to book at least 63 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Spartanburg to Des Moines?

Currently, June is the cheapest month in which you can book a flight from Spartanburg to Des Moines (average of $208). Flying from Spartanburg to Des Moines in January is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to DSM?

Find hourly flight availability from Spartanburg to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

When flying from Spartanburg to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 9% versus a flight in the evening.

What is the cheapest day to fly from Spartanburg to Des Moines?

Use this chart to determine the cheapest time to fly round-trip from Spartanburg to Des Moines. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Spartanburg to Des Moines flight should consider departing on Saturday afternoons when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Spartanburg to Des Moines

Explore weekly flight availability from Spartanburg to Des Moines. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated December 12, 2025.

The most flights from SB1 to DSM are scheduled on a Tuesday (3 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated December 12, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Spartanburg to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,007 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Spartanburg?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Des Moines from Spartanburg. Booking flights from Spartanburg to Des Moines (DSM) should be relatively easy as there are 2 daily inbound flights from Spartanburg from 3 different airlines.

  • How popular is this Spartanburg to Des Moines flight route?

    This flight path from Spartanburg to Des Moines was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Spartanburg to Des Moines one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $42. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Spartanburg to Des Moines for a low price.

  • What are the cheapest flights from Spartanburg to Des Moines?

    The cheapest flight price from Spartanburg to Des Moines is $397. On average you can expect to pay $421. The most popular route, (Charlotte Douglas - Des Moines), can usually be booked for $387.

  • Can I find deals for flights from Spartanburg to Des Moines that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Des Moines.

  • Can I find deals for business class flights from Spartanburg to Des Moines?

    Yes. Cheapflights offers flight deals from Spartanburg to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Spartanburg to Des Moines?

    Currently, June is the cheapest month in which you can book a flight from Spartanburg to Des Moines (average of $208). Flying from Spartanburg to Des Moines in January is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Top 3 airlines flying from Spartanburg to Des Moines

Discover the top 3 airlines that operate flights from Spartanburg to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$367FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$462FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$384FlexibilityNo cancel feeOn-time71%

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