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Des Moines

$104+ Cheap flights from Spartanburg, SC to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/29. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — DSM
Aug 10 — Aug 171
Sun 8/10
Sun 8/17
1 adult, Economy
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Cheapflights Tip: The best prices from Spartanburg to Des Moines are usually found in March or September, booked 45 days in advance, depart on a Tuesday or Thursday and return on a Wednesday

Cheap flight deals from Spartanburg to Des Moines

Keep the following information in mind while searching for Spartanburg to Des Moines flight deals. Data was last updated August 5, 2025.

Round-trip from

$231
(Mytrip)

One-way from

$104
(Mytrip)

Popular in

December

Cheapest in

March

Average price

$406
From Spartanburg to Des Moines
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One-way flight from Spartanburg to Des Moines
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Highest demand for flights based on searches. 6% potential increase in price ($26 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Spartanburg to Des Moines

Cheapest flights from Spartanburg to Des Moines
Explore the most affordable flight options available from Spartanburg to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 5, 2025.

This Mytrip deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/222:52 pmCLT - DSM
1 stop6h 49mMultiple Airlines
Sun 8/247:15 pmDSM - CLT
2 stops24h 08mMultiple Airlines
Deal found 8/4$231
This Mytrip deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/222:52 pmCLT - DSM
1 stop6h 49mMultiple Airlines
Mon 8/254:29 pmDSM - CLT
2 stops14h 36mMultiple Airlines
Deal found 8/4$232
This Mytrip deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/199:10 amCLT - DSM
1 stop6h 30mMultiple Airlines
Sun 9/215:49 pmDSM - CLT
2 stops21h 42mMultiple Airlines
Deal found 8/4$244
This Mytrip deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/269:10 amCLT - DSM
1 stop6h 30mMultiple Airlines
Sun 9/285:49 pmDSM - CLT
2 stops21h 42mMultiple Airlines
Deal found 8/5$247
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/411:19 amCLT - DSM
1 stop6h 03mDelta
Sat 10/116:05 amDSM - CLT
1 stop5h 06mDelta
Deal found 8/4$255
This Mytrip deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/189:52 pmCLT - DSM
2 stops16h 40mMultiple Airlines
Thu 9/255:49 pmDSM - CLT
2 stops18h 04mMultiple Airlines
Deal found 8/4$258
This Mytrip deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/292:52 pmCLT - DSM
1 stop6h 17mMultiple Airlines
Mon 9/14:30 pmDSM - CLT
2 stops14h 35mMultiple Airlines
Deal found 8/4$261
This Mytrip deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/39:10 amCLT - DSM
1 stop6h 40mMultiple Airlines
Sun 10/58:47 pmDSM - CLT
2 stops18h 44mMultiple Airlines
Deal found 8/4$269

Cheapflights Fare Finder

 
Customize your flight search to find flights from Spartanburg to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 5, 2025.
Use the filters below to find and compare flights from Spartanburg to Des Moines that are best for you.

Fly from

Spartanburg

Fly to

Des Moines

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Fri 8/22

2:52 pm-8:41 pm

1 stop6h 49m

Des Moines

Sun 8/24

7:15 pm-8:23 pm

2 stops24h 08m

$231

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Fri 8/22

2:52 pm-8:41 pm

1 stop6h 49m

Des Moines

Mon 8/25

4:29 pm-8:05 am

2 stops14h 36m

$232

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Fri 9/19

9:10 am-2:40 pm

1 stop6h 30m

Des Moines

Sun 9/21

5:49 pm-4:31 pm

2 stops21h 42m

$244

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Fri 9/26

9:10 am-2:40 pm

1 stop6h 30m

Des Moines

Sun 9/28

5:49 pm-4:31 pm

2 stops21h 42m

$247

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Sat 10/4

11:19 am-4:22 pm

1 stop6h 03m

Des Moines

Sat 10/11

6:05 am-12:11 pm

1 stop5h 06m

$255

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 9/18

9:52 pm-1:32 pm

2 stops16h 40m

Des Moines

Thu 9/25

5:49 pm-12:53 pm

2 stops18h 04m

$258

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Fri 8/29

2:52 pm-8:09 pm

1 stop6h 17m

Des Moines

Mon 9/1

4:30 pm-8:05 am

2 stops14h 35m

$261

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Fri 10/3

9:10 am-2:50 pm

1 stop6h 40m

Des Moines

Sun 10/5

8:47 pm-4:31 pm

2 stops18h 44m

$269

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Fri 8/29

2:52 pm-8:09 pm

1 stop6h 17m

$104

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 9/4

9:52 pm-1:32 pm

2 stops16h 40m

$114

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/4

Showing 1-10 of 19 results
1
2

Best time to book a flight from Spartanburg to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Des Moines

How far ahead should I book a flight from Spartanburg to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from Spartanburg to Des Moines. Price data was last updated on August 1, 2025.

To ensure you get the cheapest price possible for a flight from Spartanburg to Des Moines, you should look to book at least 45 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Spartanburg to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Spartanburg to Des Moines (average of $336). Flying from Spartanburg to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to DSM?

Find hourly flight availability from Spartanburg to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 5, 2025.

When flying from Spartanburg to Des Moines, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Spartanburg to Des Moines?

Use this chart to determine the cheapest time to fly round-trip from Spartanburg to Des Moines. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Spartanburg to Des Moines flight should consider departing on Tuesday mornings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated August 5, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Spartanburg to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,246 reviews
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,985 reviews
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,916 reviews
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Frontier
5.9
Fair
3,232 reviews
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Spartanburg?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Des Moines from Spartanburg. Booking flights from Spartanburg to Des Moines (DSM) should be relatively easy as there are 0 daily inbound flights from Spartanburg from 3 different airlines.

  • What are the cheapest flights from Spartanburg to Des Moines?

    The cheapest flight price from Spartanburg to Des Moines is $373. On average you can expect to pay $446. The most popular route, (Charlotte Douglas - Des Moines), can usually be booked for $231.

  • Can I find deals for flights from Spartanburg to Des Moines that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Des Moines.

  • Can I find deals for business class flights from Spartanburg to Des Moines?

    Yes. Cheapflights offers flight deals from Spartanburg to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Spartanburg to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Spartanburg to Des Moines (average of $336). Flying from Spartanburg to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

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Top 3 airlines flying from Spartanburg to Des Moines

Discover the top 3 airlines that operate flights from Spartanburg to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 5, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$384FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$247Average$385FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$293Average$353FlexibilityNo cancel feeOn-time69%

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