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Des Moines

$118+ Cheap flights from Spartanburg, SC to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — DSM
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Find cheap flights from Spartanburg to Des Moines with Cheapflights

1. Tell us where you want to go

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Cheapflights Tip: The best prices from Spartanburg to Des Moines are usually found in September or March, booked 65 days in advance, depart on a Wednesday or Sunday and return on a Wednesday

Cheap flight deals from Spartanburg to Des Moines

Cheapest flights from Spartanburg to Des Moines
Explore the most affordable flight options available from Spartanburg to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:00 am
CLT
-
DSM
2 stops37h 04m
Multiple Airlines
Thu 3/57:27 pm
DSM
-
CLT
1 stop22h 21m
Multiple Airlines
Deal found 1/27$231
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/191:24 pm
CLT
-
DSM
1 stop10h 48m
Multiple Airlines
Mon 2/238:38 pm
DSM
-
CLT
2 stops26h 18m
Multiple Airlines
Deal found 1/28$248
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1211:00 am
CLT
-
DSM
1 stop13h 12m
Multiple Airlines
Mon 2/168:38 pm
DSM
-
CLT
2 stops34h 48m
Multiple Airlines
Deal found 1/28$276
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/56:00 am
CLT
-
DSM
1 stop17h 46m
Multiple Airlines
Sun 2/84:30 pm
DSM
-
CLT
2 stops27h 47m
Multiple Airlines
Deal found 1/28$316
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2112:22 pm
CLT
-
DSM
1 stop11h 09m
Multiple Airlines
Mon 5/259:59 pm
DSM
-
CLT
2 stops33h 27m
Multiple Airlines
Deal found 1/29$344
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/512:55 pm
CLT
-
DSM
1 stop9h 25m
Southwest
Tue 2/108:35 am
DSM
-
CLT
1 stop8h 55m
Southwest
Deal found 1/27$349
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/158:46 pm
CLT
-
DSM
Nonstop2h 32m
American Airlines
Tue 4/211:38 pm
DSM
-
CLT
Nonstop2h 24m
American Airlines
Deal found 1/26$351
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/51:24 pm
CLT
-
DSM
1 stop10h 27m
Multiple Airlines
Sat 3/148:21 pm
DSM
-
CLT
1 stop21h 27m
Multiple Airlines
Deal found 1/27$357

Find flight deals from Spartanburg to Des Moines

Keep the following information in mind while searching for Spartanburg to Des Moines flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$231
(Kiwi.com)

One-way from

$118
(Kiwi.com)

Popular in

November

Cheapest in

September

Average price

$431
Provider with most accurate pricing for Charlotte Douglas-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charlotte Douglas-Des Moines flights.
Search Deals
From Spartanburg to Des Moines
Search Deals
One-way flight from Spartanburg to Des Moines
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($24 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Spartanburg to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Spartanburg to Des Moines that are best for you.

Fly from

Spartanburg

Fly to

Des Moines

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 2/26

7:00 am-7:04 pm

2 stops37h 04m

Des Moines

Thu 3/5

7:27 pm-6:48 pm

1 stop22h 21m

$231

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 2/25

1:35 pm-7:20 pm

1 stop6h 45m

Des Moines

Wed 3/4

8:35 am-6:30 pm

1 stop8h 55m

$349

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Tue 2/24

1:35 pm-7:20 pm

1 stop6h 45m

Des Moines

Tue 3/3

8:35 am-6:30 pm

1 stop8h 55m

$349

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 4/15

7:35 am-11:25 am

1 stop4h 50m

Des Moines

Tue 4/21

3:15 pm-8:55 pm

1 stop4h 40m

$349

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 6/17

8:20 am-11:30 am

1 stop4h 10m

Des Moines

Tue 6/30

3:45 pm-9:10 pm

1 stop4h 25m

$349

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 2/25

1:24 pm-2:18 pm

2 stops25h 54m

$135

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 4/23

6:00 am-4:00 pm

1 stop11h 00m

$136

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 2/26

11:00 am-11:06 pm

1 stop13h 06m

$137

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Sun 3/1

5:03 pm-6:32 pm

1 stop26h 29m

$144

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Tue 3/24

7:48 pm-7:16 pm

2 stops24h 28m

$147

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/29

Showing 1-10 of 15 results
1
2

Best time to book a flight from Spartanburg to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Des Moines

How far ahead should I book a flight from Spartanburg to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from Spartanburg to Des Moines. Price data was last updated on January 23, 2026.

To ensure you get the cheapest price possible for a flight from Spartanburg to Des Moines, you should look to book at least 63 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Spartanburg to Des Moines?

Currently, June is the cheapest month in which you can book a flight from Spartanburg to Des Moines (average of $208). Flying from Spartanburg to Des Moines in January is currently the most expensive (average of $308). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to DSM?

Find hourly flight availability from Spartanburg to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

When flying from Spartanburg to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 21% versus a flight in the evening.

What is the cheapest day to fly from Spartanburg to Des Moines?

Use this chart to determine the cheapest time to fly round-trip from Spartanburg to Des Moines. Price data was last updated on January 24, 2026.

Travelers seeking maximum savings on their Spartanburg to Des Moines flight should consider departing on Saturday afternoons when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated January 29, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Spartanburg to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,205 reviews
Delta
7.9
Good
8,128 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Spartanburg?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Des Moines from Spartanburg. Booking flights from Spartanburg to Des Moines (DSM) should be relatively easy as there is 1 daily inbound flight from Spartanburg from 3 different airlines.

  • How popular is this Spartanburg to Des Moines flight route?

    This flight path from Spartanburg to Des Moines was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Spartanburg to Des Moines?

    A quick flight from Spartanburg to Des Moines can take about 6h 45m. Southwest provides one of the quickest options available for as low as $349. The distance between Spartanburg and Des Moines is about 813 mi.

  • What are the cheapest flights from Spartanburg to Des Moines?

    The cheapest flight price from Spartanburg to Des Moines is $331. On average you can expect to pay $413. The most popular route, (Charlotte Douglas - Des Moines), can usually be booked for $276.

  • Can I find deals for flights from Spartanburg to Des Moines that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Des Moines.

  • Can I find deals for business class flights from Spartanburg to Des Moines?

    Yes. Cheapflights offers flight deals from Spartanburg to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Spartanburg to Des Moines?

    Currently, June is the cheapest month in which you can book a flight from Spartanburg to Des Moines (average of $208). Flying from Spartanburg to Des Moines in January is currently the most expensive (average of $308). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Top 3 airlines flying from Spartanburg to Des Moines

Discover the top 3 airlines that operate flights from Spartanburg to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$367FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$462FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$379FlexibilityNo cancel feeOn-time71%

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