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Des Moines

$342+ Cheap flights from Myrtle Beach to Des Moines (MYR - DSM)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/28. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — DSM
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Des Moines

Cheapest flights from Myrtle Beach to Des Moines
Explore the most affordable flight options available from Myrtle Beach to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:31 pm
MYR
-
DSM
1 stop19h 29m
Multiple Airlines
Sun 5/317:30 am
DSM
-
MYR
1 stop10h 26m
Multiple Airlines
Deal found 1/24$342
This Kiwi.com deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/273:29 pm
MYR
-
DSM
1 stop23h 47m
Multiple Airlines
Sun 5/317:30 am
DSM
-
MYR
1 stop10h 26m
Multiple Airlines
Deal found 1/24$350
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/171:05 pm
MYR
-
DSM
1 stop5h 37m
Delta
Tue 6/235:45 am
DSM
-
MYR
1 stop5h 34m
Delta
Deal found 1/25$387
This American Airlines deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/178:34 pm
MYR
-
DSM
1 stop4h 17m
American Airlines
Tue 6/231:45 pm
DSM
-
MYR
2 stops6h 58m
American Airlines
Deal found 1/23$392
This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:50 am
MYR
-
DSM
2 stops7h 25m
American Airlines
Sat 5/301:45 pm
DSM
-
MYR
2 stops6h 58m
American Airlines
Deal found 1/24$398
This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:35 pm
MYR
-
DSM
1 stop7h 37m
American Airlines
Sat 5/301:45 pm
DSM
-
MYR
2 stops6h 58m
American Airlines
Deal found 1/24$462
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/104:00 pm
MYR
-
DSM
1 stop7h 29m
Delta
Thu 2/125:27 am
DSM
-
MYR
1 stop7h 06m
Delta
Deal found 1/25$467
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/1012:05 pm
MYR
-
DSM
2 stops9h 59m
American Airlines
Thu 2/125:00 am
DSM
-
MYR
2 stops8h 27m
American Airlines
Deal found 1/25$478

Find flight deals from Myrtle Beach to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$387
(Delta)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
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From Myrtle Beach Intl to Des Moines
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.

Fly from

Myrtle Beach

Fly to

Des Moines

Route

Depart

Return

Price

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 5/28

7:31 pm-2:00 pm

1 stop19h 29m

Des Moines

Sun 5/31

7:30 am-6:56 pm

1 stop10h 26m

$342

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 5/27

3:29 pm-2:16 pm

1 stop23h 47m

Des Moines

Sun 5/31

7:30 am-6:56 pm

1 stop10h 26m

$350

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 5/28

2:40 pm-9:17 pm

1 stop7h 37m

Des Moines

Sat 5/30

5:45 am-12:19 pm

1 stop5h 34m

$387

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

1:05 pm-5:42 pm

1 stop5h 37m

Des Moines

Tue 6/23

5:45 am-12:19 pm

1 stop5h 34m

$387

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 7/16

6:00 am-10:14 am

1 stop5h 14m

Des Moines

Mon 7/20

6:30 pm-11:39 pm

1 stop4h 09m

$387

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

8:34 pm-11:51 pm

1 stop4h 17m

Des Moines

Tue 6/23

1:45 pm-9:43 pm

2 stops6h 58m

$392

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/24

Compare providers for flights from Myrtle Beach to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Des Moines in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Des Moines

What is the cheapest month to book a flight from Myrtle Beach to Des Moines?

Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to Des Moines (average of $162). Flying from Myrtle Beach to Des Moines in April is currently the most expensive (average of $334). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated January 26, 2026.
Read through reviews of airlines operating flights from Myrtle Beach to Des Moines, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,189 reviews

Crew

8.0

Boarding

7.5

Food

6.4

Entertainment

6.9

Overall

7.2

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,189 reviews
American Airlines
7.2
Good
11,189 reviews

Crew

8.0

Boarding

7.5

Food

6.4

Entertainment

6.9

Overall

7.2

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Des Moines?

    For as low as $387, Delta can have you in Des Moines from Myrtle Beach in 7h 37m. The distance between Myrtle Beach and Des Moines is about 969 mi.

  • What is the cheapest airline to fly from Myrtle Beach to Des Moines round-trip?

    American Airlines, at $238, was found to be the cheapest airline from Myrtle Beach to Des Moines..

  • Can I find deals for flights from Myrtle Beach to Des Moines that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Des Moines.

  • Can I find deals for business class flights from Myrtle Beach to Des Moines?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to Des Moines (average of $162). Flying from Myrtle Beach to Des Moines in April is currently the most expensive (average of $334). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Top airline flying from Myrtle Beach to Des Moines

Discover the top airline that operate flights from Myrtle Beach to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$238Average$506FlexibilityNo cancel feeOn-time71%

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