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Des Moines

$146+ Cheap flights from Myrtle Beach to Des Moines (MYR - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/7. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — DSM
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2025.

Round-trip from

$252
(Mytrip)

One-way from

$146
(Mytrip)
From Myrtle Beach Intl to Des Moines
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One-way flight from Myrtle Beach Intl to Des Moines
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Find flight deals from Myrtle Beach to Des Moines

Cheapest flights from Myrtle Beach to Des Moines
Explore the most affordable flight options available from Myrtle Beach to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/107:36 pmMYR - DSM
2 stops22h 23mMultiple Airlines
Mon 9/158:00 amDSM - MYR
1 stop9h 41mMultiple Airlines
Deal found 7/28$252
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1012:30 pmMYR - DSM
1 stop7h 37mDelta
Mon 9/156:30 pmDSM - MYR
1 stop4h 19mDelta
Deal found 7/28$302
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/112:11 pmMYR - DSM
1 stop8h 29mAmerican Airlines
Tue 9/167:03 amDSM - MYR
2 stops10h 43mAmerican Airlines
Deal found 7/28$307
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/226:11 pmMYR - DSM
2 stops20h 59mUnited Airlines
Mon 8/256:15 pmDSM - MYR
3 stops16h 36mUnited Airlines
Deal found 7/27$774

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.

Fly from

Myrtle Beach

Fly to

Des Moines

Route

Depart

Return

Price

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 9/10

7:36 pm-4:59 pm

2 stops22h 23m

Des Moines

Mon 9/15

8:00 am-6:41 pm

1 stop9h 41m

$252

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 9/10

12:30 pm-7:07 pm

1 stop7h 37m

Des Moines

Mon 9/15

6:30 pm-11:49 pm

1 stop4h 19m

$302

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 9/11

2:11 pm-9:40 pm

1 stop8h 29m

Des Moines

Tue 9/16

7:03 am-6:46 pm

2 stops10h 43m

$307

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Fri 8/22

6:11 pm-2:10 pm

2 stops20h 59m

Des Moines

Mon 8/25

6:15 pm-11:51 am

3 stops16h 36m

$774

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 8/7

7:20 am-10:38 pm

2 stops16h 18m

$146

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 8/7

2:37 pm-9:45 pm

1 stop8h 08m

$324

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from Myrtle Beach to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Des Moines

What is the cheapest month to book a flight from Myrtle Beach to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Des Moines (average of $336). Flying from Myrtle Beach to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to DSM?

Find hourly flight availability from Myrtle Beach to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

When flying from Myrtle Beach to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 4% versus a flight at noon.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated July 29, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to Des Moines, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,979 reviews

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,979 reviews
Delta
8.0
Very good
7,979 reviews

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,979 reviews

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,979 reviews

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Myrtle Beach to Des Moines round-trip?

    Delta, at $302, was found to be the cheapest airline from Myrtle Beach to Des Moines.Alternate airlines to your destination round-trip include American Airlines and United Airlines.

  • Can I find deals for flights from Myrtle Beach to Des Moines that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Des Moines.

  • Can I find deals for business class flights from Myrtle Beach to Des Moines?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Des Moines (average of $336). Flying from Myrtle Beach to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

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Top airline flying from Myrtle Beach to Des Moines

Discover the top airline that operate flights from Myrtle Beach to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$256Average$287FlexibilityNo cancel feeOn-timeN/A

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