How long is the flight from Myrtle Beach to Des Moines?

For as low as $457, American Airlines can have you in Des Moines from Myrtle Beach in 4h 16m. The distance between Myrtle Beach and Des Moines is about 969 mi.

What is the cheapest day to fly from Myrtle Beach to Des Moines?

Travelers seeking maximum savings on their Myrtle Beach to Des Moines flight should consider departing on Thursday mornings when fares are most often at their lowest. Thursday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

What is the cheapest day to fly round-trip from Myrtle Beach to Des Moines?

Departing on a Monday is a good option for securing a great price. You can expect to save up to 18% when planning your travel around this day of the week.

Can I find deals for flights from Myrtle Beach to Des Moines that include hotel bookings?

Yes. In addition to deals on Myrtle Beach to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Myrtle Beach to Des Moines?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Des Moines.

Can I find deals for business class flights from Myrtle Beach to Des Moines?

Yes. Cheapflights offers flight deals from Myrtle Beach to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$153+ Flights from Myrtle Beach to Des Moines

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Cheap flight deals from Myrtle Beach to Des Moines

Round-trip from	$457 (American Airlines)
One-way from	$153 (Delta)

From Myrtle Beach Intl to Des Moines

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One-way flight from Myrtle Beach Intl to Des Moines

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Best flights from Myrtle Beach to Des Moines
Discover carefully curated flight deals from Myrtle Beach to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated septiembre 11, 2025.

mar. 3/106:37 pmMYR - DSM

1 stop4h 16mAmerican Airlines

mié. 3/116:56 amDSM - MYR

1 stop6h 07mAmerican Airlines

Deal found 9/9

$457

One-way flights from Myrtle Beach to Des Moines
Search for one-way flight options from Myrtle Beach to Des Moines. Find affordable one-way fares based on user searches. Data last updated septiembre 11, 2025.

vie. 11/1412:30 pmMYR - DSM

1 stop7h 48mDelta

Deal found 9/11

$153

vie. 11/141:54 pmMYR - DSM

2 stops9h 08mAmerican Airlines

Deal found 9/10

$158

Cheapflights Fare Finder

Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

mar. 3/10

6:37 pm-9:53 pm

1 stop4h 16m

Des Moines

mié. 3/11

6:56 am-2:03 pm

1 stop6h 07m

$457

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

vie. 11/14

5:46 pm-10:59 pm

1 stop6h 13m

$153

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

vie. 11/14

12:30 pm-7:18 pm

1 stop7h 48m

$153

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from Myrtle Beach to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Myrtle Beach with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Des Moines

What is the cheapest month to book a flight from Myrtle Beach to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Des Moines (average of $336). Flying from Myrtle Beach to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to DSM?

When flying from Myrtle Beach to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 4% versus a flight at noon.

Related info for your journey

How long is the flight from Myrtle Beach to Des Moines?
For as low as $457, American Airlines can have you in Des Moines from Myrtle Beach in 4h 16m. The distance between Myrtle Beach and Des Moines is about 969 mi.
Can I find deals for flights from Myrtle Beach to Des Moines that include hotel bookings?
Yes. In addition to deals on Myrtle Beach to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Myrtle Beach to Des Moines?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Des Moines.
Can I find deals for business class flights from Myrtle Beach to Des Moines?
Yes. Cheapflights offers flight deals from Myrtle Beach to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Myrtle Beach to Des Moines?
Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to Des Moines (average of $336). Flying from Myrtle Beach to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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West Des Moines

Ankeny

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$153+ Cheap flights from Myrtle Beach to Des Moines (MYR - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Myrtle Beach to Des Moines with Cheapflights

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Best flights from Myrtle Beach to Des MoinesDiscover carefully curated flight deals from Myrtle Beach to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated septiembre 11, 2025.

Discover carefully curated flight deals from Myrtle Beach to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated septiembre 11, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.

Best time to book a flight from Myrtle Beach to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Myrtle Beach with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Des Moines

What is the cheapest month to book a flight from Myrtle Beach to Des Moines?

What is the cheapest time of day to fly from MYR to DSM?

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Myrtle Beach to Des Moines?

Can I find deals for flights from Myrtle Beach to Des Moines that include hotel bookings?

How can I find direct flights from Myrtle Beach to Des Moines?

Can I find deals for business class flights from Myrtle Beach to Des Moines?

What is the cheapest month to book a flight from Myrtle Beach to Des Moines?

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Best flights from Myrtle Beach to Des Moines
Discover carefully curated flight deals from Myrtle Beach to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated septiembre 11, 2025.