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Des Moines

$194+ Cheap flights from Myrtle Beach to Des Moines (MYR - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/25. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — DSM
Apr 10 — Apr 171
Fri 4/10
Fri 4/17
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Des Moines

Cheapest flights from Myrtle Beach to Des Moines
Explore the most affordable flight options available from Myrtle Beach to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.

This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/273:08 pm
MYR
-
DSM
1 stop7h 32m
United Airlines
Tue 6/96:00 am
DSM
-
MYR
1 stop7h 12m
United Airlines
Deal found 3/10$319
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:45 am
MYR
-
DSM
1 stop9h 31m
Multiple Airlines
Sun 5/314:41 pm
DSM
-
MYR
2 stops29h 48m
Multiple Airlines
Deal found 3/7$336
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:45 am
MYR
-
DSM
1 stop9h 31m
Multiple Airlines
Thu 6/117:30 am
DSM
-
MYR
1 stop26h 27m
Multiple Airlines
Deal found 3/10$347
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/25:19 pm
MYR
-
DSM
1 stop7h 23m
American Airlines
Mon 4/65:00 am
DSM
-
MYR
1 stop5h 46m
American Airlines
Deal found 3/10$355
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:07 pm
MYR
-
DSM
1 stop7h 25m
Delta
Sun 5/316:41 pm
DSM
-
MYR
1 stop4h 16m
Delta
Deal found 3/7$361
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/262:10 pm
MYR
-
DSM
2 stops9h 00m
Southwest
Mon 6/84:40 pm
DSM
-
MYR
1 stop5h 05m
Southwest
Deal found 3/10$366
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:00 am
MYR
-
DSM
1 stop5h 14m
Delta
Tue 6/236:30 pm
DSM
-
MYR
1 stop4h 08m
Delta
Deal found 3/8$387
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:06 pm
MYR
-
DSM
1 stop7h 04m
American Airlines
Tue 6/237:00 am
DSM
-
MYR
2 stops9h 26m
American Airlines
Deal found 3/8$392

Find flight deals from Myrtle Beach to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(United Airlines)

One-way from

$194
(American Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
Search Deals
From Myrtle Beach Intl to Des Moines
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One-way flight from Myrtle Beach Intl to Des Moines
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 5/27

3:08 pm-9:40 pm

1 stop7h 32m

Des Moines

Tue 6/9

6:00 am-2:12 pm

1 stop7h 12m

$319

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Tue 5/26

2:10 pm-10:10 pm

2 stops9h 00m

Des Moines

Mon 6/8

4:40 pm-10:45 pm

1 stop5h 05m

$366
Quickest round-trip

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

6:00 am-10:14 am

1 stop5h 14m

Des Moines

Tue 6/23

6:30 pm-11:38 pm

1 stop4h 08m

$387

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 7/16

6:00 am-10:14 am

1 stop5h 14m

Des Moines

Mon 7/20

6:30 pm-11:38 pm

1 stop4h 08m

$387

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

6:06 pm-12:10 am

1 stop7h 04m

Des Moines

Tue 6/23

6:02 am-3:32 pm

2 stops8h 30m

$392
Cheapest one-way

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Mon 8/17

5:07 pm-11:26 pm

1 stop7h 19m

$194

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 6/25

5:15 am-12:50 pm

1 stop8h 35m

$194
Quickest one-way

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Fri 3/20

9:14 am-1:07 pm

1 stop4h 53m

$479

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 6/25

10:34 am-10:27 am

3 stops24h 53m

$539

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/8

Sorted by cheapest first

Compare providers for flights from Myrtle Beach to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Des Moines in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Des Moines

What is the cheapest month to book a flight from Myrtle Beach to Des Moines?

Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to Des Moines (average of $162). Flying from Myrtle Beach to Des Moines in March is currently the most expensive (average of $375). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Des Moines?

    For as low as $387, United Airlines can have you in Des Moines from Myrtle Beach in 5h 14m. The distance between Myrtle Beach and Des Moines is about 969 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Myrtle Beach to Des Moines that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Des Moines.

  • Can I find deals for business class flights from Myrtle Beach to Des Moines?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to Des Moines (average of $162). Flying from Myrtle Beach to Des Moines in March is currently the most expensive (average of $375). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ankeny
Ames
Boone
Clive
West Des Moines

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