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Des Moines

$257+ Cheap flights from Myrtle Beach to Des Moines (MYR - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/15. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — DSM
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$379
(Kiwi.com)

One-way from

$257
(Kiwi.com)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
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From Myrtle Beach Intl to Des Moines
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One-way flight from Myrtle Beach Intl to Des Moines
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Find flight deals from Myrtle Beach to Des Moines

Cheapest flights from Myrtle Beach to Des Moines
Explore the most affordable flight options available from Myrtle Beach to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/239:54 amMYR - DSM
1 stop14h 16mMultiple Airlines
Sun 12/287:30 pmDSM - MYR
1 stop21h 38mMultiple Airlines
Deal found 10/28$379
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:39 pmMYR - DSM
1 stop21h 19mMultiple Airlines
Mon 11/38:00 amDSM - MYR
1 stop23h 20mMultiple Airlines
Deal found 10/25$393
This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/303:29 pmMYR - DSM
2 stops20h 46mMultiple Airlines
Thu 11/209:19 amDSM - MYR
1 stop13h 35mMultiple Airlines
Deal found 10/27$432
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2312:40 pmMYR - DSM
2 stops11h 30mSouthwest
Sat 12/275:40 amDSM - MYR
2 stops15h 10mSouthwest
Deal found 10/28$483
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2312:40 pmMYR - DSM
2 stops11h 30mSouthwest
Sun 12/285:30 amDSM - MYR
2 stops13h 05mSouthwest
Deal found 10/28$494

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.

Fly from

Myrtle Beach

Fly to

Des Moines

Route

Depart

Return

Price

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Tue 12/23

9:54 am-11:10 pm

1 stop14h 16m

Des Moines

Sun 12/28

7:30 pm-6:08 pm

1 stop21h 38m

$379

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Tue 3/10

5:37 pm-10:32 pm

1 stop5h 55m

Des Moines

Wed 3/11

6:56 am-2:03 pm

1 stop6h 07m

$457

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Tue 3/10

1:00 pm-4:56 pm

1 stop4h 56m

Des Moines

Wed 3/11

10:15 am-5:56 pm

2 stops6h 41m

$457

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Tue 12/23

12:40 pm-11:10 pm

2 stops11h 30m

Des Moines

Sat 12/27

5:40 am-9:50 pm

2 stops15h 10m

$483

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Sun 3/15

5:04 pm-12:33 pm

3 stops44h 29m

$257

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Sun 3/15

2:05 pm-11:35 pm

1 stop10h 30m

$270

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Sun 3/15

5:04 pm-9:36 am

2 stops17h 32m

$287

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Compare providers for flights from Myrtle Beach to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Des Moines in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Myrtle Beach-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Des Moines

What is the cheapest month to book a flight from Myrtle Beach to Des Moines?

Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to Des Moines (average of $162). Flying from Myrtle Beach to Des Moines in April is currently the most expensive (average of $334). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Des Moines?

    For as low as $457, American Airlines can have you in Des Moines from Myrtle Beach in 5h 55m. The distance between Myrtle Beach and Des Moines is about 969 mi.

  • Can I find deals for flights from Myrtle Beach to Des Moines that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Des Moines.

  • Can I find deals for business class flights from Myrtle Beach to Des Moines?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to Des Moines (average of $162). Flying from Myrtle Beach to Des Moines in April is currently the most expensive (average of $334). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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