$359+ Cheap flights from Medford to Des Moines (MFR - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — DSM
Nov 13 — Nov 201
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Medford to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Medford to Des Moines
Cheapest
Best
Last-minute
Cheapest flights from Medford to Des MoinesExplore the most affordable flight options available from Medford to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2026.
Explore the most affordable flight options available from Medford to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2026.
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:00 pm -
1 stop5h 36m
Wed 11/185:09 pm -
1 stop6h 09m
Deal found 10/14![United Airlines logo]()
$359
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/112:06 pm -
2 stops7h 36m
Thu 11/191:27 pm -
2 stops10h 51m
Deal found 10/14![United Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:15 am -
2 stops9h 34m
Tue 11/172:59 pm -
2 stops10h 56m
Deal found 10/14![Delta logo]()
$439
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:15 am -
2 stops9h 34m
Thu 11/192:48 pm -
2 stops10h 39m
Deal found 10/14![Delta logo]()
$449
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:00 pm -
1 stop5h 36m
Mon 11/95:09 pm -
1 stop6h 09m
Deal found 10/12![United Airlines logo]()
$469
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:01 am -
2 stops12h 15m
Wed 11/185:09 pm -
1 stop6h 09m
Deal found 10/14![United Airlines logo]()
$474
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/101:00 pm -
1 stop5h 36m
Thu 11/195:30 am -
2 stops8h 15m
Deal found 10/14![United Airlines logo]()
$484
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/201:00 pm -
1 stop5h 36m
Mon 11/305:09 pm -
1 stop6h 09m
Deal found 10/14![United Airlines logo]()
$577
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/225:00 am -
1 stop6h 51m
Tue 12/296:04 pm -
1 stop7h 24m
Deal found 10/11![American Airlines logo]()
$775
Best flights from Medford to Des MoinesDiscover carefully curated flight deals from Medford to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 14, 2026.
Discover carefully curated flight deals from Medford to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 14, 2026.
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:00 pm -
1 stop5h 36m
Wed 11/185:09 pm -
1 stop6h 09m
Deal found 10/14![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:15 am -
2 stops9h 34m
Thu 11/192:48 pm -
2 stops10h 39m
Deal found 10/14![Delta logo]()
$449
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:45 pm -
2 stops12h 47m
Mon 11/95:09 pm -
1 stop6h 09m
Deal found 10/11![United Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:01 am -
1 stop5h 30m
Tue 11/175:09 pm -
1 stop6h 09m
Deal found 10/14![United Airlines logo]()
$469
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:01 am -
1 stop5h 30m
Wed 11/185:09 pm -
1 stop6h 09m
Deal found 10/14![United Airlines logo]()
$469
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:01 am -
1 stop5h 30m
Tue 11/1711:22 am -
2 stops11h 56m
Deal found 10/14![United Airlines logo]()
$474
Last-minute flights from Medford to Des MoinesDiscover last-minute flight deals from Medford to Des Moines. Data last updated October 14, 2026 and is based on user searches.
Discover last-minute flight deals from Medford to Des Moines. Data last updated October 14, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:00 pm -
1 stop5h 36m
Mon 11/95:09 pm -
1 stop6h 09m
Deal found 10/12![United Airlines logo]()
$469
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:15 am -
2 stops9h 34m
Tue 11/172:59 pm -
2 stops10h 56m
Deal found 10/14![Delta logo]()
$439
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:15 am -
2 stops9h 34m
Thu 11/192:48 pm -
2 stops10h 39m
Deal found 10/14![Delta logo]()
$449
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:01 am -
1 stop5h 30m
Tue 11/1711:22 am -
2 stops11h 56m
Deal found 10/14![United Airlines logo]()
$474
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/101:00 pm -
1 stop5h 36m
Thu 11/195:30 am -
2 stops8h 15m
Deal found 10/14![United Airlines logo]()
$484
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:00 pm -
1 stop5h 36m
Wed 11/185:09 pm -
1 stop6h 09m
Deal found 10/14![United Airlines logo]()
$359
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/112:06 pm -
2 stops7h 36m
Thu 11/191:27 pm -
2 stops10h 51m
Deal found 10/14![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/201:00 pm -
1 stop5h 36m
Mon 11/305:09 pm -
1 stop6h 09m
Deal found 10/14![United Airlines logo]()
$577
Find flight deals from Medford to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $359 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Medford to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 14, 2026.
Use the filters below to find and compare flights from Medford to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Wed 11/11
1:00 pm-8:36 pm
1 stop5h 36m
Des Moines
Wed 11/18
5:09 pm-9:18 pm
1 stop6h 09m
$359
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Fri 11/6
7:45 pm-10:32 am
2 stops12h 47m
Des Moines
Mon 11/9
5:09 pm-9:18 pm
1 stop6h 09m
$364
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Tue 11/10
5:15 am-4:49 pm
2 stops9h 34m
Des Moines
Thu 11/19
2:48 pm-11:27 pm
2 stops10h 39m
$449
Quickest round-trip
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Wed 11/11
5:01 am-12:31 pm
1 stop5h 30m
Des Moines
Tue 11/17
5:09 pm-9:18 pm
1 stop6h 09m
$469
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Tue 11/10
5:01 am-12:31 pm
1 stop5h 30m
Des Moines
Wed 11/18
5:09 pm-9:18 pm
1 stop6h 09m
$469
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Tue 11/10
5:01 am-12:31 pm
1 stop5h 30m
Des Moines
Tue 11/17
11:22 am-9:18 pm
2 stops11h 56m
$474
Sorted by cheapest first
Compare providers for flights from Medford to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Des Moines in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Medford-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Medford-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Medford-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Medford-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Medford to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Medford with our price prediction graph.
MFR-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 14, 2026.
Peruse reviews from past customers who have flown with United Airlines from Medford to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.4
Crew
8.1
Comfort
7.3
Entertainment
7.1
Boarding
7.7
Food
6.7
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Overall
7.4
Crew
8.1
Comfort
7.3
Entertainment
7.1
Boarding
7.7
Food
6.7
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from Medford to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Des Moines flight routes
Flights by cabin class
Other flight options
Other flights from Medford
Popular flights
Alternative routes for Medford to Des Moines
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 14, 2026.
Search flights from Medford to Des Moines by cabin class
Find flights from Medford to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Medford and Des Moines flights
Browse other Medford and Des Moines flight options. Last updated on October 14, 2026.
Other flights from Medford
Browse through other flights departing from Medford. Flights are based on user searches made on Cheapflights and were last updated on October 14, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Medford to Des Moines
Discover the top airline that operate flights from Medford to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$338 | Average$598 | FlexibilityNo cancel fee | On-time69% |