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Des Moines

$191+ Cheap flights from Medford to Des Moines (MFR - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/3. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — DSM
May 25 — Jun 11
Mon 5/25
Mon 6/1
1 adult, Economy
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Find cheap flights from Medford to Des Moines with Cheapflights

1. Tell us where you want to go

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Cheap flight deals from Medford to Des Moines

Cheapest flights from Medford to Des Moines
Explore the most affordable flight options available from Medford to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 25, 2026.

This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:26 pm
MFR
-
DSM
2 stops13h 45m
United Airlines
Fri 8/215:16 pm
DSM
-
MFR
1 stop6h 00m
United Airlines
Deal found 4/21$388
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:00 am
MFR
-
DSM
2 stops12h 16m
United Airlines
Sun 5/105:30 am
DSM
-
MFR
2 stops8h 17m
United Airlines
Deal found 4/21$409
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/131:32 pm
MFR
-
DSM
1 stop8h 25m
American Airlines
Sat 8/222:39 pm
DSM
-
MFR
1 stop6h 41m
American Airlines
Deal found 4/21$432
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/112:52 pm
MFR
-
DSM
1 stop5h 24m
United Airlines
Tue 5/55:17 pm
DSM
-
MFR
1 stop6h 14m
United Airlines
Deal found 4/20$444
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/142:06 pm
MFR
-
DSM
2 stops7h 49m
United Airlines
Sat 8/221:40 pm
DSM
-
MFR
2 stops11h 01m
United Airlines
Deal found 4/21$461
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:26 pm
MFR
-
DSM
2 stops13h 45m
United Airlines
Tue 8/185:50 am
DSM
-
MFR
2 stops8h 12m
United Airlines
Deal found 4/21$494
This Alaska Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/307:35 pm
MFR
-
DSM
2 stops10h 47m
Alaska Airlines
Tue 8/42:26 pm
DSM
-
MFR
2 stops11h 38m
Alaska Airlines
Deal found 4/20$504
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:36 pm
MFR
-
DSM
2 stops12h 47m
United Airlines
Wed 5/205:17 pm
DSM
-
MFR
1 stop6h 14m
United Airlines
Deal found 4/23$529
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/131:32 pm
MFR
-
DSM
1 stop8h 25m
American Airlines
Fri 8/215:45 am
DSM
-
MFR
1 stop9h 02m
American Airlines
Deal found 4/21$532

Find flight deals from Medford to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 25, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$388
(United Airlines)

One-way from

$191
(Kiwi.com)
Provider with most accurate pricing for Medford-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Medford-Des Moines flights.
Search Deals
From Medford to Des Moines
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One-way flight from Medford to Des Moines
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 25, 2026.
Use the filters below to find and compare flights from Medford to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Thu 8/13

6:26 pm-10:11 am

2 stops13h 45m

Des Moines

Tue 8/18

5:16 pm-9:16 pm

1 stop6h 00m

$388

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Thu 8/13

1:32 pm-11:57 pm

1 stop8h 25m

Des Moines

Tue 8/18

5:45 am-12:47 pm

1 stop9h 02m

$432

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Thu 7/30

7:35 pm-8:22 am

2 stops10h 47m

Des Moines

Tue 8/4

2:26 pm-12:04 am

2 stops11h 38m

$504

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Fri 5/15

6:36 pm-9:23 am

2 stops12h 47m

Des Moines

Wed 5/20

5:17 pm-9:31 pm

1 stop6h 14m

$529

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Wed 6/17

5:00 am-12:36 pm

1 stop5h 36m

Des Moines

Tue 6/23

1:35 pm-10:59 pm

2 stops11h 24m

$559

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Fri 5/15

4:11 pm-9:54 pm

2 stops27h 43m

Des Moines

Wed 5/20

5:19 am-3:34 pm

2 stops12h 15m

$608

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Wed 6/17

3:52 pm-8:12 am

2 stops14h 20m

Des Moines

Tue 6/23

2:24 pm-12:04 am

2 stops11h 40m

$646
Quickest round-trip

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Thu 7/30

1:10 pm-8:30 pm

1 stop5h 20m

Des Moines

Tue 8/4

5:50 am-12:04 pm

2 stops8h 14m

$648

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Fri 5/15

6:36 pm-9:23 am

2 stops12h 47m

Des Moines

Mon 5/18

5:17 pm-9:31 pm

1 stop6h 14m

$731
Cheapest one-way

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sun 5/3

9:12 pm-7:25 pm

1 stop20h 13m

$191

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/24

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Compare providers for flights from Medford to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Des Moines in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Medford-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Medford-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Medford-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Medford-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Medford to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Medford to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Medford to Des Moines?

    Departing from Medford to Des Moines will take you 8h 25m. There are 1494 mi between Medford and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Medford to Des Moines that include hotel bookings?

    Yes. In addition to deals on Medford to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to Des Moines.

  • Can I find deals for business class flights from Medford to Des Moines?

    Yes. Cheapflights offers flight deals from Medford to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny

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