$349+ Cheap flights from Medford to Des Moines (MFR - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — DSM
Dec 13 — Dec 201
Round-trip
1 adult, Economy
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Find cheap flights from Medford to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Medford to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Medford to Des MoinesExplore the most affordable flight options available from Medford to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2026.
Explore the most affordable flight options available from Medford to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2026.
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/275:04 am -
1 stop6h 35m
Tue 12/15:00 am -
1 stop9h 58m
Deal found 11/12![American Airlines logo]()
$469
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/276:00 am -
2 stops8h 07m
Tue 12/15:15 pm -
1 stop6h 11m
Deal found 11/12![United Airlines logo]()
$474
Best flights from Medford to Des MoinesDiscover carefully curated flight deals from Medford to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 13, 2026.
Discover carefully curated flight deals from Medford to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 13, 2026.
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/195:00 am -
1 stop5h 54m
Thu 1/288:00 am -
2 stops14h 09m
Deal found 11/8![United Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/215:05 am -
2 stops10h 10m
Sat 1/3012:25 pm -
2 stops11h 44m
Deal found 11/8![Delta logo]()
$389
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/305:04 am -
2 stops12h 03m
Tue 2/92:27 pm -
1 stop7h 12m
Deal found 11/12![American Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/236:00 am -
2 stops8h 11m
Sat 2/68:00 am -
2 stops14h 09m
Deal found 11/8![United Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3012:40 pm -
1 stop5h 58m
Tue 2/96:15 am -
2 stops13h 19m
Deal found 11/11![United Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2012:40 pm -
1 stop5h 58m
Sat 1/3011:22 am -
2 stops12h 08m
Deal found 11/11![United Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/166:00 am -
2 stops12h 38m
Sat 1/2311:22 am -
2 stops10h 47m
Deal found 11/8![United Airlines logo]()
$410
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/276:00 am -
2 stops8h 07m
Tue 12/15:15 pm -
1 stop6h 11m
Deal found 11/12![United Airlines logo]()
$474
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/66:00 am -
2 stops8h 11m
Sat 1/99:25 am -
2 stops12h 44m
Deal found 11/10![United Airlines logo]()
$499
Last-minute flights from Medford to Des MoinesDiscover last-minute flight deals from Medford to Des Moines. Data last updated November 13, 2026 and is based on user searches.
Discover last-minute flight deals from Medford to Des Moines. Data last updated November 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/275:04 am -
1 stop6h 35m
Tue 12/15:00 am -
1 stop9h 58m
Deal found 11/12![American Airlines logo]()
$469
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/276:00 am -
2 stops8h 07m
Tue 12/15:15 pm -
1 stop6h 11m
Deal found 11/12![United Airlines logo]()
$474
One-way flights from Medford to Des MoinesSearch for one-way flight options from Medford to Des Moines. Find affordable one-way fares based on user searches. Data last updated November 13, 2026.
Search for one-way flight options from Medford to Des Moines. Find affordable one-way fares based on user searches. Data last updated November 13, 2026.
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1112:47 pm -
1 stop5h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/10![United Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:55 pm -
3 stops44h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/10![Multiple Airlines logo]()
$774
Find flight deals from Medford to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $379 (American Airlines) |
One-way from | $349 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Medford to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 13, 2026.
Use the filters below to find and compare flights from Medford to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Fri 12/11
12:47 pm-8:33 pm
1 stop5h 46m
Des Moines
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$349
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Tue 1/19
5:00 am-12:54 pm
1 stop5h 54m
Des Moines
Thu 1/28
8:00 am-8:09 pm
2 stops14h 09m
$384
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Thu 1/21
5:05 am-5:15 pm
2 stops10h 10m
Des Moines
Sat 1/30
12:25 pm-10:09 pm
2 stops11h 44m
$389
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Sat 1/23
6:00 am-4:11 pm
2 stops8h 11m
Des Moines
Sat 2/6
8:00 am-8:09 pm
2 stops14h 09m
$389
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Sat 1/30
5:04 am-7:07 pm
2 stops12h 03m
Des Moines
Tue 2/9
2:27 pm-7:39 pm
1 stop7h 12m
$394
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Sat 1/30
12:40 pm-8:38 pm
1 stop5h 58m
Des Moines
Tue 2/9
6:15 am-5:34 pm
2 stops13h 19m
$394
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Wed 1/20
12:40 pm-8:38 pm
1 stop5h 58m
Des Moines
Sat 1/30
11:22 am-9:30 pm
2 stops12h 08m
$394
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Sat 1/16
6:00 am-8:38 pm
2 stops12h 38m
Des Moines
Sat 1/23
11:22 am-8:09 pm
2 stops10h 47m
$410
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Fri 11/27
6:00 am-4:07 pm
2 stops8h 07m
Des Moines
Tue 12/1
5:15 pm-9:26 pm
1 stop6h 11m
$474
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Wed 1/6
6:00 am-4:11 pm
2 stops8h 11m
Des Moines
Sat 1/9
9:25 am-8:09 pm
2 stops12h 44m
$499
Sorted by cheapest first
Compare providers for flights from Medford to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Des Moines in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Medford-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Medford-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Medford-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Medford-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Medford to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Medford with our price prediction graph.
MFR-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated November 13, 2026.
Peruse reviews from past customers who have flown with United Airlines from Medford to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.3
Boarding
7.7
Overall
7.3
Food
6.7
Crew
8.1
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Comfort
7.3
Boarding
7.7
Overall
7.3
Food
6.7
Crew
8.1
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from Medford to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
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Medford and Des Moines flights
Browse other Medford and Des Moines flight options. Last updated on November 13, 2026.
Other flights from Medford
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Top airline flying from Medford to Des Moines
Discover the top airline that operate flights from Medford to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$358 | Average$508 | FlexibilityNo cancel fee | On-time69% |