$378+ Cheap flights from Medford to Des Moines (MFR - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — DSM
Nov 8 — Nov 151
Round-trip
1 adult, Economy
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Find cheap flights from Medford to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Medford to Des Moines
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Best
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One-way
Cheapest flights from Medford to Des MoinesExplore the most affordable flight options available from Medford to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 9, 2026.
Explore the most affordable flight options available from Medford to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 9, 2026.
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:00 pm -
1 stop5h 36m
Fri 11/275:09 pm -
1 stop6h 09m
Deal found 10/8![United Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/231:30 pm -
1 stop8h 14m
Wed 1/62:27 pm -
1 stop7h 03m
Deal found 10/7![American Airlines logo]()
$581
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/15:04 am -
1 stop6h 34m
Sat 12/57:14 am -
2 stops11h 32m
Deal found 10/8![American Airlines logo]()
$636
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:10 am -
2 stops8h 01m
Sat 12/512:33 pm -
2 stops11h 43m
Deal found 10/8![Delta logo]()
$654
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/112:47 pm -
1 stop5h 46m
Sat 12/55:15 pm -
1 stop6h 11m
Deal found 10/8![United Airlines logo]()
$657
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/235:00 am -
1 stop13h 25m
Wed 1/69:00 am -
2 stops11h 13m
Deal found 10/7![United Airlines logo]()
$660
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:15 am -
2 stops9h 34m
Fri 11/276:45 am -
2 stops8h 06m
Deal found 10/8![Delta logo]()
$669
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/251:28 pm -
1 stop8h 08m
Mon 11/306:02 pm -
1 stop7h 22m
Deal found 10/8![American Airlines logo]()
$690
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:04 am -
1 stop7h 33m
Sun 11/295:00 am -
1 stop9h 58m
Deal found 10/6![American Airlines logo]()
$776
Best flights from Medford to Des MoinesDiscover carefully curated flight deals from Medford to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 9, 2026.
Discover carefully curated flight deals from Medford to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 9, 2026.
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:25 am -
2 stops12h 11m
Fri 11/275:09 pm -
1 stop6h 09m
Deal found 10/8![United Airlines logo]()
$429
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/175:55 am -
2 stops8h 02m
Sat 1/234:00 pm -
2 stops8h 19m
Deal found 10/5![Delta logo]()
$539
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/236:00 am -
2 stops8h 11m
Wed 1/279:00 am -
2 stops11h 13m
Deal found 10/7![United Airlines logo]()
$479
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Tue 12/16:10 am -
2 stops8h 01m
Sat 12/512:33 pm -
2 stops11h 43m
Deal found 10/8![Delta logo]()
$654
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/235:00 am -
1 stop13h 25m
Wed 1/69:00 am -
2 stops11h 13m
Deal found 10/7![United Airlines logo]()
$660
Last-minute flights from Medford to Des MoinesDiscover last-minute flight deals from Medford to Des Moines. Data last updated October 9, 2026 and is based on user searches.
Discover last-minute flight deals from Medford to Des Moines. Data last updated October 9, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:00 pm -
1 stop5h 36m
Fri 11/275:09 pm -
1 stop6h 09m
Deal found 10/8![United Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:15 am -
2 stops9h 34m
Fri 11/276:45 am -
2 stops8h 06m
Deal found 10/8![Delta logo]()
$669
This Orbitz deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:33 am -
2 stops11h 21m
Fri 11/275:00 am -
3 stops14h 04m
Deal found 10/8![Alaska Airlines logo]()
$1,772
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/251:28 pm -
1 stop8h 08m
Mon 11/306:02 pm -
1 stop7h 22m
Deal found 10/8![American Airlines logo]()
$690
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/252:06 pm -
2 stops7h 36m
Mon 11/305:09 pm -
1 stop6h 09m
Deal found 10/8![United Airlines logo]()
$1,048
This Expedia deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:41 pm -
2 stops13h 20m
Mon 11/301:58 pm -
2 stops12h 01m
Deal found 10/8![Alaska Airlines logo]()
$1,110
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:04 am -
1 stop7h 33m
Sun 11/295:00 am -
1 stop9h 58m
Deal found 10/6![American Airlines logo]()
$776
This deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:01 am -
1 stop5h 30m
Sun 11/295:09 pm -
1 stop6h 09m
Deal found 10/8![United Airlines logo]()
$1,043
One-way flights from Medford to Des MoinesSearch for one-way flight options from Medford to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 9, 2026.
Search for one-way flight options from Medford to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/154:49 pm -
1 stop16h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Allegiant Air logo]()
$378
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/141:22 pm -
1 stop8h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![American Airlines logo]()
$476
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/142:08 pm -
2 stops7h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![United Airlines logo]()
$481
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:00 am -
2 stops10h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![United Airlines logo]()
$504
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/154:49 pm -
3 stops24h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Multiple Airlines logo]()
$617
Find flight deals from Medford to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $424 (United Airlines) |
One-way from | $378 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Medford to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 9, 2026.
Use the filters below to find and compare flights from Medford to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Wed 11/18
6:25 am-8:36 pm
2 stops12h 11m
Des Moines
Fri 11/27
5:09 pm-9:18 pm
1 stop6h 09m
$429
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Sat 1/23
6:00 am-4:11 pm
2 stops8h 11m
Des Moines
Wed 1/27
9:00 am-6:13 pm
2 stops11h 13m
$479
Quickest round-trip
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Wed 10/14
2:08 pm-11:48 pm
2 stops7h 40m
Des Moines
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$481
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Thu 10/15
5:00 am-5:48 pm
2 stops10h 48m
Des Moines
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$504
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Sun 1/17
5:55 am-3:57 pm
2 stops8h 02m
Des Moines
Sat 1/23
4:00 pm-10:19 pm
2 stops8h 19m
$539
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Tue 12/1
6:10 am-4:11 pm
2 stops8h 01m
Des Moines
Sat 12/5
12:33 pm-10:16 pm
2 stops11h 43m
$654
MedfordDes Moines
MFR Medford - DSM Des Moines
MFRDSM
Medford
Wed 12/23
5:00 am-8:25 pm
1 stop13h 25m
Des Moines
Wed 1/6
9:00 am-6:13 pm
2 stops11h 13m
$660
Sorted by cheapest first
Compare providers for flights from Medford to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Des Moines in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Medford-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Medford-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Medford-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Medford-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Medford to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Medford with our price prediction graph.
MFR-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 9, 2026.
Peruse reviews from past customers who have flown with United Airlines from Medford to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Entertainment
7.1
Comfort
7.3
Boarding
7.7
Food
6.7
Overall
7.4
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Crew
8.1
Entertainment
7.1
Comfort
7.3
Boarding
7.7
Food
6.7
Overall
7.4
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from Medford to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
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Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 9, 2026.
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Medford and Des Moines flights
Browse other Medford and Des Moines flight options. Last updated on October 9, 2026.
Other flights from Medford
Browse through other flights departing from Medford. Flights are based on user searches made on Cheapflights and were last updated on October 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Medford to Des Moines
Discover the top airline that operate flights from Medford to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$338 | Average$598 | FlexibilityNo cancel fee | On-time69% |