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Des Moines

$384+ Cheap flights from Medford to Des Moines (MFR - DSM)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — DSM
Dec 20 — Dec 271
Sat 12/20
Sat 12/27
1 adult, Economy
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Find flight deals from Medford to Des Moines

Cheapest flights from Medford to Des Moines
Explore the most affordable flight options available from Medford to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 20, 2025.

This United Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/612:50 pmMFR - DSM
1 stop5h 58mUnited Airlines
Wed 12/105:15 pmDSM - MFR
1 stop6h 14mUnited Airlines
Deal found 11/19$384
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/21:37 pmMFR - DSM
1 stop8h 22mAmerican Airlines
Tue 12/162:33 pmDSM - MFR
1 stop7h 38mAmerican Airlines
Deal found 11/19$422
This United Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/28:00 amMFR - DSM
2 stops10h 48mUnited Airlines
Tue 12/165:15 pmDSM - MFR
1 stop6h 14mUnited Airlines
Deal found 11/19$424
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/211:45 pmMFR - DSM
1 stop8h 09mAmerican Airlines
Fri 11/285:10 amDSM - MFR
1 stop9h 50mAmerican Airlines
Deal found 11/18$439
This United Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2112:47 pmMFR - DSM
1 stop5h 58mUnited Airlines
Fri 11/281:05 pmDSM - MFR
2 stops11h 25mUnited Airlines
Deal found 11/18$593
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/285:20 amMFR - DSM
1 stop6h 29mAmerican Airlines
Sun 11/305:10 amDSM - MFR
1 stop9h 50mAmerican Airlines
Deal found 11/18$655
This Alaska Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/218:57 pmMFR - DSM
2 stops18h 34mAlaska Airlines
Fri 11/2811:30 amDSM - MFR
2 stops13h 15mAlaska Airlines
Deal found 11/18$712

Cheap flight deals from Medford to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 20, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$384
(United Airlines)

Popular in

November

Cheapest in

September

Average price

$909
Provider with most accurate pricing for Medford-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Medford-Des Moines flights.
Search Deals
From Medford to Des Moines
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($47 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($34 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
Use the filters below to find and compare flights from Medford to Des Moines that are best for you.

Fly from

Medford

Fly to

Des Moines

Route

Depart

Return

Price

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 12/6

12:50 pm-8:48 pm

1 stop5h 58m

Des Moines

Wed 12/10

5:15 pm-9:29 pm

1 stop6h 14m

$384

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Tue 12/2

8:00 am-8:48 pm

2 stops10h 48m

Des Moines

Tue 12/16

5:15 pm-9:29 pm

1 stop6h 14m

$424

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Wed 5/13

5:10 am-12:34 pm

1 stop5h 24m

Des Moines

Wed 5/20

5:03 pm-9:10 pm

1 stop6h 07m

$439

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Wed 4/15

5:00 am-12:50 pm

1 stop5h 50m

Des Moines

Sat 4/18

5:30 am-11:34 am

2 stops8h 04m

$444

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/19

Compare providers for flights from Medford to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Des Moines in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Medford-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Medford-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Medford-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Medford-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Medford to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to Des Moines

What is the cheapest month to book a flight from Medford to Des Moines?

Currently, September is the cheapest month in which you can book a flight from Medford to Des Moines (average of $268). Flying from Medford to Des Moines in November is currently the most expensive (average of $909). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated November 20, 2025.
Peruse reviews from past customers who have flown with United Airlines from Medford to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,029 reviews

Boarding

7.7

Food

6.6

Entertainment

7.1

Overall

7.4

Comfort

7.3

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000
United Airlines
7.4
Good
9,029 reviews
United Airlines
7.4
Good
9,029 reviews

Boarding

7.7

Food

6.6

Entertainment

7.1

Overall

7.4

Comfort

7.3

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

Related info for your journey

Find useful and relevant information for your journey from Medford to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Medford to Des Moines?

    Departing from Medford to Des Moines will take you 5h 58m. There are 1494 mi between Medford and Des Moines.

  • What is the cheapest airline to fly from Medford to Des Moines round-trip?

    Cheapflights users have booked flights from Medford to Des Moines round-trip from $266. United Airlines is priced at 50% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Medford to Des Moines that include hotel bookings?

    Yes. In addition to deals on Medford to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to Des Moines.

  • Can I find deals for business class flights from Medford to Des Moines?

    Yes. Cheapflights offers flight deals from Medford to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Medford to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from Medford to Des Moines (average of $268). Flying from Medford to Des Moines in November is currently the most expensive (average of $909). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Top airline flying from Medford to Des Moines

Discover the top airline that operate flights from Medford to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$266Average$509FlexibilityNo cancel feeOn-time69%

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