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$244+ Cheap flights from Medford to Des Moines (MFR - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/29. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — DSM
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheap flight deals from Medford to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2025.

Round-trip from

$329
(American Airlines)

One-way from

$244
(Kiwi.com)

Popular in

April

Cheapest in

January

Average price

$448
From Medford to Des Moines
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One-way flight from Medford to Des Moines
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Highest demand for flights based on searches. 11% potential increase in price ($71 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($26 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Medford to Des Moines

Cheapest flights from Medford to Des Moines
Explore the most affordable flight options available from Medford to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/102:40 pmMFR - DSM
1 stop7h 38mAmerican Airlines
Wed 9/178:16 amDSM - MFR
1 stop7h 12mAmerican Airlines
Deal found 8/12$329
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:35 pmMFR - DSM
2 stops14h 04mUnited Airlines
Wed 9/175:15 pmDSM - MFR
1 stop5h 49mUnited Airlines
Deal found 8/12$340
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/226:35 pmMFR - DSM
2 stops14h 04mUnited Airlines
Sat 9/278:00 amDSM - MFR
3 stops14h 29mUnited Airlines
Deal found 8/14$364
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/222:40 pmMFR - DSM
1 stop7h 38mAmerican Airlines
Sat 9/278:16 amDSM - MFR
1 stop7h 12mAmerican Airlines
Deal found 8/14$414
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/151:52 pmMFR - DSM
1 stop8h 22mAmerican Airlines
Sun 8/175:30 amDSM - MFR
1 stop9h 40mAmerican Airlines
Deal found 8/13$511
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/165:00 amMFR - DSM
1 stop5h 51mUnited Airlines
Sun 8/176:00 amDSM - MFR
2 stops7h 52mUnited Airlines
Deal found 8/13$644

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Medford to Des Moines that are best for you.

Fly from

Medford

Fly to

Des Moines

Route

Depart

Return

Price

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Wed 9/10

2:40 pm-12:18 am

1 stop7h 38m

Des Moines

Wed 9/17

8:16 am-1:28 pm

1 stop7h 12m

$329

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Wed 9/10

6:35 pm-10:39 am

2 stops14h 04m

Des Moines

Wed 9/17

5:15 pm-9:04 pm

1 stop5h 49m

$340

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Mon 9/22

6:35 pm-10:39 am

2 stops14h 04m

Des Moines

Sat 9/27

8:00 am-8:29 pm

3 stops14h 29m

$364

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Mon 9/22

2:40 pm-12:18 am

1 stop7h 38m

Des Moines

Sat 9/27

8:16 am-1:28 pm

1 stop7h 12m

$414

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Fri 8/29

9:51 pm-10:32 pm

2 stops46h 41m

$244

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Fri 8/29

1:52 pm-12:14 am

1 stop8h 22m

$313

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Best time to book a flight from Medford to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to Des Moines

What is the cheapest month to book a flight from Medford to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Medford to Des Moines (average of $336). Flying from Medford to Des Moines in June is currently the most expensive (average of $401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated August 14, 2025.
Peruse reviews from past customers who have flown with United Airlines and American Airlines from Medford to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,916 reviews

Crew

8.1

Food

6.6

Boarding

7.7

Comfort

7.3

Overall

7.4

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
United Airlines
7.4
Good
8,916 reviews
United Airlines
7.4
Good
8,916 reviews

Crew

8.1

Food

6.6

Boarding

7.7

Comfort

7.3

Overall

7.4

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,916 reviews

Crew

8.1

Food

6.6

Boarding

7.7

Comfort

7.3

Overall

7.4

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

Related info for your journey

Find useful and relevant information for your journey from Medford to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Medford to Des Moines round-trip?

    Cheapflights users have booked flights from Medford to Des Moines round-trip from $266. Another airline that can offer you cheap pricing is American Airlines. United Airlines is priced at 49% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Medford to Des Moines that include hotel bookings?

    Yes. In addition to deals on Medford to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to Des Moines.

  • Can I find deals for business class flights from Medford to Des Moines?

    Yes. Cheapflights offers flight deals from Medford to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Medford to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Medford to Des Moines (average of $336). Flying from Medford to Des Moines in June is currently the most expensive (average of $401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

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Top 2 airlines flying from Medford to Des Moines

Discover the top 2 airlines that operate flights from Medford to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$266Average$509FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$268Average$398FlexibilityNo cancel feeOn-time71%

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