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$53+ Cheap flights from South Carolina to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/4. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — CHI
Mar 13 — Mar 201
Fri 3/13
Fri 3/20
1 adult, Economy
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Cheap flight deals from South Carolina to Chicago

Cheapest flights from South Carolina to Chicago
Explore the most affordable flight options available from South Carolina to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.

This Frontier deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1910:42 pm
CLT
-
ORD
Nonstop2h 31m
Frontier
Mon 3/237:11 pm
ORD
-
CLT
Nonstop2h 02m
Frontier
Deal found 2/9$62
This Super.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2010:42 pm
CLT
-
ORD
Nonstop2h 31m
Frontier
Mon 3/237:11 pm
ORD
-
CLT
Nonstop2h 02m
Frontier
Deal found 2/10$65
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:26 pm
CLT
-
ORD
Nonstop2h 27m
Frontier
Mon 5/45:16 pm
ORD
-
CLT
Nonstop2h 15m
Frontier
Deal found 2/9$76
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/149:26 pm
CLT
-
ORD
Nonstop2h 27m
Frontier
Mon 5/185:16 pm
ORD
-
CLT
Nonstop2h 15m
Frontier
Deal found 2/11$77
This Frontier deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/610:46 pm
CLT
-
ORD
Nonstop2h 31m
Frontier
Mon 3/97:11 pm
ORD
-
CLT
Nonstop2h 02m
Frontier
Deal found 2/8$78
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/249:26 pm
CLT
-
ORD
Nonstop2h 27m
Frontier
Sun 4/265:16 pm
ORD
-
CLT
Nonstop2h 15m
Frontier
Deal found 2/10$81
This Frontier deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:26 pm
CLT
-
ORD
Nonstop2h 27m
Frontier
Mon 4/205:16 pm
ORD
-
CLT
Nonstop2h 15m
Frontier
Deal found 2/8$82
This Frontier deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/2610:46 pm
CLT
-
ORD
Nonstop2h 31m
Frontier
Thu 4/21:02 pm
ORD
-
CLT
Nonstop2h 10m
Frontier
Deal found 2/9$87
This Priceline deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1910:42 pm
CLT
-
ORD
Nonstop2h 31m
Multiple Airlines
Mon 3/236:01 pm
ORD
-
CLT
1 stop4h 52m
Multiple Airlines
Deal found 2/10$89
This Mytrip deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:00 pm
CHS
-
ORD
1 stop8h 40m
Spirit Airlines
Tue 3/176:01 pm
ORD
-
CHS
1 stop16h 08m
Spirit Airlines
Deal found 2/10$118
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/293:35 pm
CHS
-
MDW
1 stop22h 25m
Multiple Airlines
Wed 5/67:30 am
MDW
-
CHS
1 stop6h 10m
Multiple Airlines
Deal found 2/8$127
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/293:35 pm
CHS
-
ORD
1 stop8h 08m
Spirit Airlines
Tue 5/54:47 pm
ORD
-
CHS
1 stop14h 53m
Spirit Airlines
Deal found 2/8$128

Find flight deals from South Carolina to Chicago

Keep the following information in mind while searching for South Carolina to Chicago flight deals. Data was last updated February 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$62
(Frontier)

One-way from

$53
(Cheapflightsfares)

Popular in

November

Cheapest in

August

Average price

$368

Good round-trip deal

$303 or less

Good one-way deal

$151 or less
Provider with most accurate pricing for Myrtle Beach Intl-Chicago (CHI) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Chicago (CHI) flights.
Search Deals
From South Carolina to Chicago (CHI)
Search Deals
One-way flight from South Carolina to Chicago (CHI)
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($66 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a round-trip flight from South Carolina to Chicago (CHI).
Search Deals
Price to beat on a one-way flight from South Carolina to Chicago (CHI).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from South Carolina to Chicago that are best for you.

Fly from

South Carolina

Fly to

Chicago

Route

Depart

Return

Price

CharlotteChicago

CLT - ORD

CLTORD

Charlotte Douglas

Thu 4/23

9:26 pm-10:53 pm

Nonstop2h 27m

Chicago O'Hare Intl

Mon 4/27

5:16 pm-8:31 pm

Nonstop2h 15m

$76

CharlotteChicago

CLT - ORD

CLTORD

Charlotte Douglas

Thu 4/23

9:26 pm-10:53 pm

Nonstop2h 27m

Chicago O'Hare Intl

Sat 4/25

7:06 am-2:13 pm

1 stop6h 07m

$121

CharlotteChicago

CLT - ORD

CLTORD

Charlotte Douglas

Thu 4/23

9:26 pm-10:53 pm

Nonstop2h 27m

Chicago O'Hare Intl

Sun 4/26

5:16 pm-8:31 pm

Nonstop2h 15m

$122

CharlestonChicago

CHS - MDW

CHSMDW

Charleston

Tue 5/5

3:35 pm-1:00 pm

1 stop22h 25m

Chicago Midway

Sat 5/9

7:30 am-2:40 pm

1 stop6h 10m

$130

CharlotteChicago

CLT - MDW

CLTMDW

Charlotte Douglas

Thu 4/23

9:28 pm-1:00 pm

1 stop16h 32m

Chicago Midway

Sat 4/25

9:14 am-6:22 pm

1 stop8h 08m

$138

CharlotteChicago

CLT - ORD

CLTORD

Charlotte Douglas

Fri 3/6

10:46 pm-12:17 am

Nonstop2h 31m

Chicago O'Hare Intl

Sun 3/8

6:55 pm-9:57 pm

Nonstop2h 02m

$143

GreenvilleChicago

GSP - ORD

GSPORD

Greenville

Sat 3/7

5:40 am-10:17 am

1 stop5h 37m

Chicago O'Hare Intl

Wed 3/11

6:00 am-2:56 pm

1 stop7h 56m

$147

GreenvilleChicago

GSP - MDW

GSPMDW

Greenville

Sat 3/7

7:20 am-12:46 pm

1 stop6h 26m

Chicago Midway

Wed 3/11

6:07 pm-11:54 pm

1 stop4h 47m

$147

CharlotteChicago

CLT - ORD

CLTORD

Charlotte Douglas

Wed 4/29

6:30 am-6:54 pm

2 stops13h 24m

Chicago O'Hare Intl

Sun 5/3

5:16 pm-8:31 pm

Nonstop2h 15m

$147

CharlotteChicago

CLT - ORD

CLTORD

Charlotte Douglas

Thu 4/23

8:55 am-7:47 pm

1 stop11h 52m

Chicago O'Hare Intl

Sat 4/25

5:05 am-2:13 pm

1 stop8h 08m

$148

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/11

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Chicago

What is the cheapest month to book a flight from South Carolina to Chicago?

Currently, June is the cheapest month in which you can book a flight from South Carolina to Chicago (average of $95). Flying from South Carolina to Chicago in February is currently the most expensive (average of $202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to CHI?

Find hourly flight availability from South Carolina to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 11, 2026.

When flying from South Carolina to Chicago, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 27% versus a flight at noon.

What is the cheapest day to fly from South Carolina to Chicago?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Chicago. Price data was last updated on February 7, 2026.

Travelers seeking maximum savings on their South Carolina to Chicago flight should consider departing on Friday at noon when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from South Carolina to Chicago?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Chicago?

    Frontier, Delta, and Spirit Airlines can get you from South Carolina to Chicago in just under 2h 27m. Your travel time can differ by up to 13h 04m. Airlines will cover a distance of 599 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Chicago one-way?

    $58 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $93 and $99, respectively.

  • What are the most popular routes from South Carolina to Chicago?

    While some choose either Charleston - Chicago O'Hare Intl or Charlotte Douglas - Chicago Midway, Charlotte Douglas - Chicago O'Hare Intl is the most popular route from South Carolina to Chicago.

  • What are the most reliable airlines from South Carolina to Chicago?

    Consider PSA Airlines (100%), Envoy Air (84%) or Qatar Airways (83%) when booking your flight. These represent the most reliable airlines when flying from South Carolina to Chicago.

  • What are the cheapest flights from South Carolina to Chicago?

    The cheapest flight price from South Carolina to Chicago is $125. On average you can expect to pay $939. The most popular route, (Charlotte Douglas - Chicago O'Hare Intl), can usually be booked for $90.

  • Can I find deals for flights from South Carolina to Chicago that include hotel bookings?

    Yes. In addition to deals on South Carolina to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Chicago.

  • Can I find deals for business class flights from South Carolina to Chicago?

    Yes. Cheapflights offers flight deals from South Carolina to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Chicago?

    Currently, June is the cheapest month in which you can book a flight from South Carolina to Chicago (average of $95). Flying from South Carolina to Chicago in February is currently the most expensive (average of $202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lansing
Merrillville
Hammond
Porter
Benton Harbor

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Alternative routes for South Carolina to Chicago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from South Carolina to Chicago

Discover the top 5 airlines that operate flights from South Carolina to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$65Average$193FlexibilityNo cancel feeOn-time65%
DeltaCheapest$107Average$372FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$135Average$339FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$178Average$367FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$190Average$368FlexibilityNo cancel feeOn-time63%

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