$53+ Cheap flights from Knoxville (TYS) to Chicago (CHI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHI
Nov 29 — Dec 61
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Chicago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Chicago are usually found in January or April, booked 46 days in advance, depart on a Friday or Thursday and return on a Thursday
Cheap flight deals from Knoxville to Chicago
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Cheapest flights from Knoxville to ChicagoExplore the most affordable flight options available from Knoxville to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from Knoxville to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/163:04 pm -
Nonstop1h 37m
Fri 11/202:30 pm -
Nonstop1h 27m
Deal found 10/29![Allegiant Air logo]()
$228
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:46 pm -
Nonstop2h 12m
Mon 1/189:32 pm -
Nonstop1h 56m
Deal found 10/29![American Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:30 am -
2 stops34h 17m
Mon 11/239:29 am -
Nonstop1h 27m
Deal found 10/29![Multiple Airlines logo]()
$241
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:40 am -
1 stop5h 45m
Mon 11/232:44 pm -
1 stop5h 45m
Deal found 10/29![Delta logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/131:49 pm -
Nonstop1h 37m
Tue 11/176:08 am -
2 stops28h 58m
Deal found 10/29![Multiple Airlines logo]()
$243
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/58:35 pm -
Nonstop2h 12m
Mon 12/712:55 pm -
1 stop7h 50m
Deal found 10/28![American Airlines logo]()
$243
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1011:22 am -
Nonstop2h 22m
Tue 1/199:32 pm -
Nonstop1h 56m
Deal found 10/29![American Airlines logo]()
$245
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/15:15 pm -
1 stop6h 30m
Thu 12/39:40 am -
2 stops10h 10m
Deal found 10/28![Southwest logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:39 pm -
2 stops27h 08m
Mon 11/239:29 am -
Nonstop1h 27m
Deal found 10/29![Multiple Airlines logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/199:54 pm -
2 stops34h 39m
Mon 11/239:29 am -
Nonstop1h 27m
Deal found 10/29![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/201:01 pm -
Nonstop1h 39m
Mon 11/231:16 pm -
2 stops31h 50m
Deal found 10/26![Multiple Airlines logo]()
$251
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:50 pm -
Nonstop2h 09m
Fri 11/275:19 am -
1 stop4h 14m
Deal found 10/28![American Airlines logo]()
$251
Best flights from Knoxville to ChicagoDiscover carefully curated flight deals from Knoxville to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from Knoxville to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:40 am -
1 stop5h 45m
Mon 11/232:44 pm -
1 stop5h 45m
Deal found 10/29![Delta logo]()
$241
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:50 pm -
Nonstop2h 09m
Fri 11/271:20 pm -
Nonstop1h 42m
Deal found 10/29![American Airlines logo]()
$241
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/52:50 pm -
1 stop5h 45m
Mon 12/71:15 pm -
2 stops6h 35m
Deal found 10/28![Southwest logo]()
$246
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:45 am -
Nonstop2h 09m
Sun 11/156:55 am -
Nonstop1h 58m
Deal found 10/26![United Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:26 pm -
1 stop5h 30m
Sat 12/122:41 pm -
1 stop4h 19m
Deal found 10/26![Delta logo]()
$253
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:00 pm -
1 stop6h 05m
Sun 11/225:05 am -
1 stop4h 35m
Deal found 10/28![Southwest logo]()
$285
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:40 am -
1 stop4h 46m
Wed 12/92:41 pm -
1 stop5h 52m
Deal found 10/26![Delta logo]()
$265
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/22:36 pm -
1 stop5h 33m
Sat 12/122:41 pm -
1 stop4h 19m
Deal found 10/26![Delta logo]()
$265
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2112:40 pm -
2 stops9h 25m
Mon 1/412:45 pm -
2 stops6h 50m
Deal found 10/28![Southwest logo]()
$299
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:10 am -
1 stop4h 49m
Fri 12/116:16 pm -
1 stop4h 41m
Deal found 10/26![Delta logo]()
$265
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/247:10 pm -
1 stop5h 34m
Wed 1/271:55 pm -
Nonstop1h 59m
Deal found 10/28![United Airlines logo]()
$354
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:25 pm -
1 stop5h 45m
Sat 12/193:40 pm -
1 stop5h 00m
Deal found 10/28![Southwest logo]()
$324
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:40 am -
1 stop5h 48m
Sun 12/136:00 am -
1 stop6h 51m
Deal found 10/26![Delta logo]()
$285
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:40 pm -
Nonstop2h 03m
Sun 11/85:59 pm -
Nonstop1h 55m
Deal found 10/27![United Airlines logo]()
$409
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/216:00 am -
1 stop4h 13m
Mon 1/410:47 am -
1 stop4h 07m
Deal found 10/28![Delta logo]()
$289
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:26 pm -
1 stop5h 30m
Sun 1/175:30 am -
1 stop5h 30m
Deal found 10/29![Delta logo]()
$290
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/25:40 am -
1 stop5h 48m
Sun 12/61:41 pm -
1 stop3h 41m
Deal found 10/26![Delta logo]()
$302
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/277:10 am -
1 stop5h 15m
Fri 12/46:00 am -
1 stop4h 27m
Deal found 10/26![Delta logo]()
$312
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:10 am -
1 stop6h 41m
Sun 11/226:00 am -
1 stop4h 28m
Deal found 10/29![Delta logo]()
$320
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:10 pm -
1 stop4h 07m
Tue 11/242:44 pm -
1 stop5h 45m
Deal found 10/26![Delta logo]()
$324
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:07 pm -
1 stop5h 47m
Mon 11/166:00 am -
1 stop4h 28m
Deal found 10/25![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/67:10 am -
1 stop6h 51m
Sun 12/136:00 am -
1 stop4h 27m
Deal found 10/26![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/307:25 am -
1 stop6h 21m
Sat 1/26:25 am -
1 stop6h 14m
Deal found 10/25![Delta logo]()
$364
Last-minute flights from Knoxville to ChicagoDiscover last-minute flight deals from Knoxville to Chicago. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Chicago. Data last updated October 30, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/610:03 pm -
2 stops20h 44m
Mon 11/94:31 pm -
Nonstop1h 30m
Deal found 10/27![Multiple Airlines logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/131:49 pm -
Nonstop1h 37m
Tue 11/176:08 am -
2 stops28h 58m
Deal found 10/29![Multiple Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1410:55 am -
2 stops13h 52m
Mon 11/239:29 am -
Nonstop1h 27m
Deal found 10/29![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/163:04 pm -
Nonstop1h 37m
Fri 11/202:30 pm -
Nonstop1h 27m
Deal found 10/29![Allegiant Air logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/163:54 pm -
2 stops26h 53m
Mon 11/239:29 am -
Nonstop1h 27m
Deal found 10/29![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:30 am -
2 stops34h 17m
Mon 11/239:29 am -
Nonstop1h 27m
Deal found 10/29![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:39 pm -
2 stops27h 08m
Mon 11/239:29 am -
Nonstop1h 27m
Deal found 10/29![Multiple Airlines logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1812:56 pm -
1 stop29h 11m
Mon 11/239:29 am -
Nonstop1h 27m
Deal found 10/26![Allegiant Air logo]()
$262
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:40 am -
1 stop5h 45m
Mon 11/232:44 pm -
1 stop5h 45m
Deal found 10/29![Delta logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/199:54 pm -
2 stops34h 39m
Mon 11/239:29 am -
Nonstop1h 27m
Deal found 10/29![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/201:01 pm -
Nonstop1h 39m
Mon 11/231:16 pm -
2 stops31h 50m
Deal found 10/26![Multiple Airlines logo]()
$251
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:50 pm -
Nonstop2h 09m
Fri 11/275:19 am -
1 stop4h 14m
Deal found 10/28![American Airlines logo]()
$251
One-way flights from Knoxville to ChicagoSearch for one-way flight options from Knoxville to Chicago. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from Knoxville to Chicago. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This CheapOair deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/201:01 pm -
Nonstop1h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Allegiant Air logo]()
$53
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/71:58 pm -
1 stop7h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$98
This Super.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:04 pm -
Nonstop1h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Allegiant Air logo]()
$101
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/145:07 pm -
Nonstop2h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1712:53 pm -
1 stop29h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$115
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:17 pm -
1 stop5h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Delta logo]()
$121
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/147:26 pm -
1 stop5h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Delta logo]()
$121
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:30 am -
2 stops16h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:30 am -
2 stops35h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Multiple Airlines logo]()
$125
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/58:15 am -
2 stops10h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![Southwest logo]()
$126
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:44 am -
Nonstop2h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$131
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:55 am -
2 stops12h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Southwest logo]()
$132
Find flight deals from Knoxville to Chicago
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Chicago (CHI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $228 (Kiwi.com) |
One-way from | $53 (CheapOair) |
Popular in | September |
Cheapest in | January |
Average price | $347 |
Good round-trip deal | $192 or less |
Good one-way deal | $99 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from Knoxville to Chicago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Mon 11/9
3:04 pm-3:41 pm
Nonstop1h 37m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$101
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Thu 11/19
5:40 pm-6:43 pm
Nonstop2h 03m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$111
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Tue 12/1
5:15 pm-10:45 pm
1 stop6h 30m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$121
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Wed 12/9
6:17 pm-10:54 pm
1 stop5h 37m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$121
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Tue 12/8
1:00 pm-6:05 pm
1 stop6h 05m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$121
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Tue 12/1
7:10 am-10:59 am
1 stop4h 49m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$121
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Wed 12/9
1:00 pm-6:05 pm
1 stop6h 05m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$121
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Mon 12/14
5:10 pm-8:15 pm
1 stop4h 05m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$121
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Tue 11/10
8:30 am-6:30 pm
2 stops35h 00m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$125
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Sat 12/5
8:15 am-5:25 pm
2 stops10h 10m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$126
Showing 1-10 of 44 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Chicago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Chicago in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Chicago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Chicago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Chicago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Chicago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Chicago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Chicago
Have a flexible travel schedule? Discover the best time to fly to Chicago from Knoxville with our price prediction graph.
TYS-CHI
TYS-MDW
TYS-ORD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Chicago
TYS-CHI
TYS-MDW
TYS-ORD
What is the cheapest month to book a flight from Knoxville to Chicago?
Currently, January is the cheapest month in which you can book a flight from Knoxville to Chicago (average of $245). Flying from Knoxville to Chicago in September is currently the most expensive (average of $390). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from TYS to CHI?
Find hourly flight availability from Knoxville to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2026.
It’s typically best to fly out from Knoxville to Chicago in the evening. Doing so could potentially save you 46% on the flight price compared to flying at noon, which is usually more expensive.
How much does it cost to fly round-trip from Knoxville to Chicago?
Airfare is typical for this route at the moment.
Knoxville to Chicago flights typically cost between $199 and $425 in November.The cheapest round-trip price found within the last 5 days was $228 on Allegiant Air (Nov 16-Nov 20).
How far ahead should I book a flight from Knoxville to Chicago?
The best time to book flights from Knoxville to Chicago is 36 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest day to fly from Knoxville to Chicago?
Use this chart to determine the cheapest time to fly round-trip from Knoxville to Chicago. Price data was last updated on October 24, 2026.
Travelers seeking maximum savings on their Knoxville to Chicago flight should consider departing on Monday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing Chicago
Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated October 30, 2026.
Peruse reviews from past customers who have flown with Southwest,United Airlines, andAllegiant Air from Knoxville to Chicago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Entertainment
7.4
Food
7.0
Overall
7.9
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Crew
8.6
Entertainment
7.4
Food
7.0
Overall
7.9
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Crew
8.6
Entertainment
7.4
Food
7.0
Overall
7.9
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Crew
8.6
Entertainment
7.4
Food
7.0
Overall
7.9
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Crew
8.6
Entertainment
7.4
Food
7.0
Overall
7.9
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Chicago?
Book flights to Chicago if you plan to visit one of these locationsBenton Harbor
Merrillville
Lansing
Valparaiso
Hammond
Saint Joseph
Porter
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Other flights to Chicago
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Knoxville and Chicago flights
Browse other Knoxville and Chicago flight options. Last updated on October 30, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Chicago
Discover the top 3 airlines that operate flights from Knoxville to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$78 | Average$148 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$189 | Average$331 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$189 | Average$312 | FlexibilityNo cancel fee | On-time71% |