$78+ Cheap flights from Knoxville (TYS) to Chicago (CHI)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHI
Aug 31 — Sep 71
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Chicago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Chicago are usually found in January or April, booked 73 days in advance, depart on a Friday or Thursday and return on a Thursday
Cheap flight deals from Knoxville to Chicago
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Cheapest flights from Knoxville to ChicagoExplore the most affordable flight options available from Knoxville to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 1, 2026.
Explore the most affordable flight options available from Knoxville to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2310:54 am
TYS
- ORD
1 stop28h 51m
Multiple Airlines
Tue 9/297:11 am
ORD
- TYS
1 stop25h 54m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$194
This Cheapflightsfares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/91:23 pm
TYS
- MDW
Nonstop1h 36m
Allegiant Air
Sun 8/162:49 pm
MDW
- TYS
Nonstop1h 30m
Allegiant Air
Deal found 7/29![Allegiant Air logo]()
$197
This Cheapflightsfares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/61:23 pm
TYS
- MDW
Nonstop1h 36m
Allegiant Air
Thu 8/132:49 pm
MDW
- TYS
Nonstop1h 30m
Allegiant Air
Deal found 7/29![Allegiant Air logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/131:23 pm
TYS
- MDW
Nonstop1h 36m
Allegiant Air
Sun 8/162:49 pm
MDW
- TYS
Nonstop1h 30m
Allegiant Air
Deal found 7/29![Allegiant Air logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/23:46 pm
TYS
- ORD
1 stop22h 04m
Multiple Airlines
Wed 9/237:11 am
ORD
- TYS
1 stop25h 53m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/910:54 am
TYS
- ORD
1 stop28h 51m
Multiple Airlines
Wed 9/167:11 am
ORD
- TYS
1 stop25h 53m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/263:49 pm
TYS
- ORD
1 stop22h 01m
Multiple Airlines
Wed 9/28:05 am
ORD
- TYS
1 stop24h 59m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/23:46 pm
TYS
- ORD
1 stop22h 04m
Multiple Airlines
Tue 9/227:11 am
ORD
- TYS
1 stop25h 53m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:54 am
TYS
- ORD
1 stop29h 26m
Multiple Airlines
Tue 9/297:11 am
ORD
- TYS
1 stop25h 54m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$215
This Cheapflightsfares deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/301:22 pm
TYS
- MDW
Nonstop1h 36m
Allegiant Air
Sun 8/22:48 pm
MDW
- TYS
Nonstop1h 30m
Allegiant Air
Deal found 7/27![Allegiant Air logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1712:50 pm
TYS
- ORD
2 stops20h 03m
Multiple Airlines
Wed 8/198:05 am
ORD
- TYS
1 stop24h 59m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:42 pm
TYS
- MDW
Nonstop1h 37m
Allegiant Air
Sun 11/810:42 am
MDW
- TYS
1 stop28h 50m
Allegiant Air
Deal found 7/27![Allegiant Air logo]()
$229
Best flights from Knoxville to ChicagoDiscover carefully curated flight deals from Knoxville to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 1, 2026.
Discover carefully curated flight deals from Knoxville to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 1, 2026.
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/104:50 pm
TYS
- MDW
1 stop8h 00m
Southwest
Sat 9/126:45 am
MDW
- TYS
1 stop5h 30m
Southwest
Deal found 7/30![Southwest logo]()
$243
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/284:38 pm
TYS
- MDW
1 stop6h 58m
Delta
Fri 9/412:46 pm
MDW
- TYS
1 stop6h 17m
Delta
Deal found 7/31![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:00 am
TYS
- ORD
Nonstop1h 56m
United Airlines
Sat 8/2210:30 am
ORD
- TYS
Nonstop1h 48m
United Airlines
Deal found 7/27![United Airlines logo]()
$329
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:55 pm
TYS
- MDW
2 stops8h 55m
Southwest
Thu 9/38:00 am
MDW
- TYS
1 stop3h 35m
Southwest
Deal found 7/27![Southwest logo]()
$248
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:45 pm
TYS
- MDW
2 stops6h 40m
Southwest
Mon 9/147:25 am
MDW
- TYS
1 stop5h 00m
Southwest
Deal found 7/27![Southwest logo]()
$248
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:15 am
TYS
- ORD
1 stop6h 53m
Delta
Fri 9/41:50 pm
ORD
- TYS
1 stop5h 13m
Delta
Deal found 7/31![Delta logo]()
$279
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:40 am
TYS
- ORD
1 stop4h 04m
Delta
Wed 9/91:55 pm
ORD
- TYS
1 stop4h 43m
Delta
Deal found 7/31![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/284:50 pm
TYS
- MDW
1 stop7h 55m
Southwest
Sat 8/296:50 am
MDW
- TYS
1 stop8h 20m
Southwest
Deal found 7/28![Southwest logo]()
$261
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:41 pm
TYS
- ORD
1 stop5h 16m
Delta
Sat 8/2911:22 am
ORD
- TYS
1 stop7h 04m
Delta
Deal found 7/28![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:45 pm
TYS
- MDW
2 stops6h 40m
Southwest
Mon 9/215:30 am
MDW
- TYS
1 stop6h 55m
Southwest
Deal found 7/29![Southwest logo]()
$266
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/152:40 pm
TYS
- ORD
1 stop5h 22m
Delta
Fri 1/19:30 am
ORD
- TYS
1 stop4h 35m
Delta
Deal found 7/27![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:30 pm
TYS
- MDW
1 stop5h 50m
Southwest
Thu 8/2011:15 am
MDW
- TYS
1 stop4h 55m
Southwest
Deal found 7/30![Southwest logo]()
$276
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:40 am
TYS
- ORD
1 stop4h 04m
Delta
Tue 9/88:05 am
ORD
- TYS
1 stop5h 35m
Delta
Deal found 7/31![Delta logo]()
$279
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:25 pm
TYS
- ORD
1 stop5h 34m
Delta
Mon 9/215:30 am
ORD
- TYS
1 stop6h 51m
Delta
Deal found 7/27![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/157:55 am
TYS
- MDW
1 stop7h 40m
Southwest
Fri 1/17:05 am
MDW
- TYS
1 stop5h 55m
Southwest
Deal found 7/27![Southwest logo]()
$286
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:18 pm
TYS
- ORD
1 stop4h 12m
Delta
Sun 10/115:27 am
ORD
- TYS
1 stop4h 27m
Delta
Deal found 7/31![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/113:40 pm
TYS
- MDW
2 stops9h 15m
Southwest
Tue 12/159:40 am
MDW
- TYS
2 stops9h 05m
Southwest
Deal found 7/31![Southwest logo]()
$297
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/182:16 pm
TYS
- ORD
1 stop5h 33m
Delta
Sat 8/221:50 pm
ORD
- TYS
1 stop5h 20m
Delta
Deal found 7/27![Delta logo]()
$279
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/247:30 am
TYS
- ORD
1 stop6h 07m
Delta
Fri 12/257:10 am
ORD
- TYS
1 stop6h 55m
Delta
Deal found 7/28![Delta logo]()
$279
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:41 pm
TYS
- MDW
1 stop3h 55m
Delta
Sat 8/2910:56 am
MDW
- TYS
1 stop3h 34m
Delta
Deal found 7/30![Delta logo]()
$299
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:40 am
TYS
- ORD
1 stop4h 04m
Delta
Tue 8/185:30 am
ORD
- TYS
1 stop4h 41m
Delta
Deal found 7/31![Delta logo]()
$309
Last-minute flights from Knoxville to ChicagoDiscover last-minute flight deals from Knoxville to Chicago. Data last updated August 1, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Chicago. Data last updated August 1, 2026 and is based on user searches.
This Cheapflightsfares deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/301:22 pm
TYS
- MDW
Nonstop1h 36m
Allegiant Air
Sun 8/22:48 pm
MDW
- TYS
Nonstop1h 30m
Allegiant Air
Deal found 7/27![Allegiant Air logo]()
$223
This Cheapflightsfares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/61:23 pm
TYS
- MDW
Nonstop1h 36m
Allegiant Air
Thu 8/132:49 pm
MDW
- TYS
Nonstop1h 30m
Allegiant Air
Deal found 7/29![Allegiant Air logo]()
$198
This Cheapflightsfares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/91:23 pm
TYS
- MDW
Nonstop1h 36m
Allegiant Air
Sun 8/162:49 pm
MDW
- TYS
Nonstop1h 30m
Allegiant Air
Deal found 7/29![Allegiant Air logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/131:23 pm
TYS
- MDW
Nonstop1h 36m
Allegiant Air
Sun 8/162:49 pm
MDW
- TYS
Nonstop1h 30m
Allegiant Air
Deal found 7/29![Allegiant Air logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1712:50 pm
TYS
- ORD
2 stops20h 03m
Multiple Airlines
Wed 8/198:05 am
ORD
- TYS
1 stop24h 59m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/179:08 pm
TYS
- ORD
1 stop27h 00m
Multiple Airlines
Sat 8/228:05 am
ORD
- TYS
1 stop24h 59m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1712:50 pm
TYS
- ORD
2 stops20h 03m
Multiple Airlines
Thu 8/205:46 pm
ORD
- TYS
1 stop23h 57m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/193:49 pm
TYS
- ORD
1 stop22h 01m
Multiple Airlines
Sat 8/228:05 am
ORD
- TYS
1 stop24h 59m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/241:26 pm
TYS
- ORD
1 stop12h 23m
Multiple Airlines
Sat 8/298:05 am
ORD
- TYS
1 stop24h 59m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:45 pm
TYS
- MDW
1 stop5h 35m
Southwest
Thu 8/2711:15 am
MDW
- TYS
1 stop4h 55m
Southwest
Deal found 7/30![Southwest logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2510:30 am
TYS
- ORD
1 stop13h 38m
Multiple Airlines
Sat 8/298:05 am
ORD
- TYS
1 stop24h 59m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/263:49 pm
TYS
- ORD
1 stop22h 01m
Multiple Airlines
Wed 9/28:05 am
ORD
- TYS
1 stop24h 59m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$212
One-way flights from Knoxville to ChicagoSearch for one-way flight options from Knoxville to Chicago. Find affordable one-way fares based on user searches. Data last updated August 1, 2026.
Search for one-way flight options from Knoxville to Chicago. Find affordable one-way fares based on user searches. Data last updated August 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1912:04 pm
TYS
- MDW
Nonstop1h 32m
Allegiant Air
Deal found 7/28![Allegiant Air logo]()
$78
This Super.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/161:23 pm
TYS
- MDW
Nonstop1h 36m
Allegiant Air
Deal found 7/29![Allegiant Air logo]()
$79
This Super.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/131:23 pm
TYS
- MDW
Nonstop1h 36m
Allegiant Air
Deal found 7/27![Allegiant Air logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:40 pm
TYS
- ORD
1 stop22h 40m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:54 am
TYS
- ORD
1 stop28h 51m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2310:54 am
TYS
- ORD
1 stop28h 51m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$114
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/88:05 am
TYS
- MDW
1 stop4h 30m
Southwest
Deal found 7/31![Southwest logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/284:14 pm
TYS
- ORD
1 stop24h 10m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/263:49 pm
TYS
- ORD
1 stop22h 01m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/285:08 pm
TYS
- ORD
1 stop20h 42m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am
TYS
- ORD
1 stop28h 31m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$128
This Super.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/78:19 pm
TYS
- ORD
1 stop25h 33m
Frontier
Deal found 7/31![Frontier logo]()
$129
Find flight deals from Knoxville to Chicago
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Chicago (CHI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $194 (Kiwi.com) |
One-way from | $78 (Kiwi.com) |
Popular in | March |
Cheapest in | January |
Average price | $249 |
Good round-trip deal | $98 or less |
Good one-way deal | $115 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2026.
Use the filters below to find and compare flights from Knoxville to Chicago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleChicago
TYS - MDW
TYSMDW
Knoxville McGhee Tyson
Thu 9/10
4:50 pm-11:50 pm
1 stop8h 00m
Chicago Midway
Sat 9/12
6:45 am-1:15 pm
1 stop5h 30m
$243
KnoxvilleChicago
TYS - MDW
TYSMDW
Knoxville McGhee Tyson
Tue 9/1
1:55 pm-9:50 pm
2 stops8h 55m
Chicago Midway
Thu 9/3
8:00 am-12:35 pm
1 stop3h 35m
$248
KnoxvilleChicago
TYS - MDW
TYSMDW
Knoxville McGhee Tyson
Thu 9/10
5:45 pm-11:25 pm
2 stops6h 40m
Chicago Midway
Mon 9/14
7:25 am-1:25 pm
1 stop5h 00m
$248
KnoxvilleChicago
TYS - MDW
TYSMDW
Knoxville McGhee Tyson
Fri 8/28
4:50 pm-11:45 pm
1 stop7h 55m
Chicago Midway
Sat 8/29
6:50 am-4:10 pm
1 stop8h 20m
$261
KnoxvilleChicago
TYS - MDW
TYSMDW
Knoxville McGhee Tyson
Fri 9/18
5:45 pm-11:25 pm
2 stops6h 40m
Chicago Midway
Mon 9/21
5:30 am-1:25 pm
1 stop6h 55m
$266
KnoxvilleChicago
TYS - MDW
TYSMDW
Knoxville McGhee Tyson
Tue 8/18
5:30 pm-10:20 pm
1 stop5h 50m
Chicago Midway
Thu 8/20
11:15 am-5:10 pm
1 stop4h 55m
$276
KnoxvilleChicago
TYS - MDW
TYSMDW
Knoxville McGhee Tyson
Fri 8/28
4:38 pm-10:36 pm
1 stop6h 58m
Chicago Midway
Fri 9/4
12:46 pm-8:03 pm
1 stop6h 17m
$279
KnoxvilleChicago
TYS - ORD
TYSORD
Knoxville McGhee Tyson
Fri 8/28
7:15 am-1:08 pm
1 stop6h 53m
Chicago O'Hare Intl
Fri 9/4
1:50 pm-8:03 pm
1 stop5h 13m
$279
KnoxvilleChicago
TYS - ORD
TYSORD
Knoxville McGhee Tyson
Thu 9/3
5:40 am-8:44 am
1 stop4h 04m
Chicago O'Hare Intl
Wed 9/9
1:55 pm-7:38 pm
1 stop4h 43m
$279
KnoxvilleChicago
TYS - ORD
TYSORD
Knoxville McGhee Tyson
Fri 8/28
7:41 pm-11:57 pm
1 stop5h 16m
Chicago O'Hare Intl
Sat 8/29
11:22 am-7:26 pm
1 stop7h 04m
$279
Showing 1-10 of 39 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Chicago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Chicago in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Chicago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Chicago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Chicago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Chicago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Chicago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Chicago
Have a flexible travel schedule? Discover the best time to fly to Chicago from Knoxville with our price prediction graph.
TYS-CHI
TYS-MDW
TYS-ORD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Chicago
TYS-CHI
TYS-MDW
TYS-ORD
What is the cheapest month to book a flight from Knoxville to Chicago?
Currently, January is the cheapest month in which you can book a flight from Knoxville to Chicago (average of $236). Flying from Knoxville to Chicago in March is currently the most expensive (average of $343). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from TYS to CHI?
Find hourly flight availability from Knoxville to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 1, 2026.
It’s typically best to fly out from Knoxville to Chicago in the morning. Doing so could potentially save you 35% on the flight price compared to flying at noon, which is usually more expensive.
Weekly flight availability from Knoxville to Chicago
Explore weekly flight availability from Knoxville to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 1, 2026.
The most flights from TYS to CHI are scheduled on a Thursday (36 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (9 on average).
How much does it cost to fly round-trip from Knoxville to Chicago?
Airfare is typical for this route at the moment.
Knoxville to Chicago flights typically cost between $189 and $299 in September.The cheapest round-trip price found within the last 5 days was $194 on Multiple Airlines (Sep 23-Sep 29).
How far ahead should I book a flight from Knoxville to Chicago?
The best time to book flights from Knoxville to Chicago is 70 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest day to fly from Knoxville to Chicago?
Use this chart to determine the cheapest time to fly round-trip from Knoxville to Chicago. Price data was last updated on August 1, 2026.
Travelers seeking maximum savings on their Knoxville to Chicago flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing Chicago
Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated August 1, 2026.
Peruse reviews from past customers who have flown with United Airlines,Allegiant Air, andAmerican Airlines from Knoxville to Chicago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.4
Comfort
7.3
Boarding
7.7
Entertainment
7.1
Crew
8.1
Food
6.7
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Overall
7.4
Comfort
7.3
Boarding
7.7
Entertainment
7.1
Crew
8.1
Food
6.7
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Overall
7.4
Comfort
7.3
Boarding
7.7
Entertainment
7.1
Crew
8.1
Food
6.7
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Overall
7.4
Comfort
7.3
Boarding
7.7
Entertainment
7.1
Crew
8.1
Food
6.7
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Chicago?
Book flights to Chicago if you plan to visit one of these locationsBenton Harbor
Lansing
Merrillville
Valparaiso
Hammond
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Porter
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Other flights to Chicago
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Knoxville and Chicago flights
Browse other Knoxville and Chicago flight options. Last updated on August 1, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on August 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Chicago
Discover the top 3 airlines that operate flights from Knoxville to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$78 | Average$141 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$189 | Average$318 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$189 | Average$312 | FlexibilityNo cancel fee | On-time71% |