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$41+ Cheap flights from Knoxville (TYS) to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/28. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHI
Jun 3 — Jun 101
Wed 6/3
Wed 6/10
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Chicago are usually found in January or August, booked 34 days in advance, depart on a Friday or Thursday and return on a Saturday

Cheap flight deals from Knoxville to Chicago

Cheapest flights from Knoxville to Chicago
Explore the most affordable flight options available from Knoxville to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 4, 2026.

This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:20 pm
TYS
-
MDW
2 stops41h 49m
Multiple Airlines
Thu 5/212:47 pm
MDW
-
TYS
Nonstop1h 26m
Multiple Airlines
Deal found 5/1$210
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:25 pm
TYS
-
MDW
1 stop15h 59m
Allegiant Air
Thu 8/132:49 pm
MDW
-
TYS
Nonstop1h 30m
Allegiant Air
Deal found 5/1$212
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:25 pm
TYS
-
MDW
1 stop15h 59m
Allegiant Air
Sun 8/162:49 pm
MDW
-
TYS
Nonstop1h 30m
Allegiant Air
Deal found 5/1$215
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:22 pm
TYS
-
MDW
Nonstop1h 35m
Multiple Airlines
Mon 5/256:00 am
MDW
-
TYS
2 stops16h 37m
Multiple Airlines
Deal found 4/29$217
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1012:40 pm
TYS
-
MDW
2 stops23h 27m
Multiple Airlines
Sun 7/122:48 pm
MDW
-
TYS
Nonstop1h 30m
Multiple Airlines
Deal found 5/3$220
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1912:40 pm
TYS
-
ORD
2 stops20h 23m
Multiple Airlines
Sat 6/208:00 pm
ORD
-
TYS
1 stop23h 48m
Multiple Airlines
Deal found 5/1$224
This Cheapflightsfares deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/161:22 pm
TYS
-
MDW
Nonstop1h 36m
Allegiant Air
Sun 7/192:48 pm
MDW
-
TYS
Nonstop1h 30m
Allegiant Air
Deal found 5/2$226
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/712:50 pm
TYS
-
MDW
2 stops10h 18m
Multiple Airlines
Thu 8/132:49 pm
MDW
-
TYS
Nonstop1h 30m
Multiple Airlines
Deal found 5/1$229
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3112:40 pm
TYS
-
MDW
2 stops23h 27m
Multiple Airlines
Sun 8/22:48 pm
MDW
-
TYS
Nonstop1h 30m
Multiple Airlines
Deal found 4/30$230
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/241:22 pm
TYS
-
MDW
Nonstop1h 35m
Allegiant Air
Mon 5/259:30 pm
MDW
-
TYS
1 stop21h 01m
Allegiant Air
Deal found 4/29$232
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/712:50 pm
TYS
-
MDW
2 stops10h 18m
Multiple Airlines
Sun 8/162:49 pm
MDW
-
TYS
Nonstop1h 30m
Multiple Airlines
Deal found 5/1$233
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/281:22 pm
TYS
-
MDW
Nonstop1h 34m
Multiple Airlines
Mon 6/296:00 am
MDW
-
TYS
2 stops14h 50m
Multiple Airlines
Deal found 4/29$238

Find flight deals from Knoxville to Chicago

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Chicago (CHI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$210
(Kiwi.com)

One-way from

$41
(Kiwi.com)

Popular in

March

Cheapest in

January

Average price

$249

Good round-trip deal

$120 or less

Good one-way deal

$80 or less
Provider with most accurate pricing for Knoxville McGhee Tyson-Chicago (CHI) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Chicago (CHI) flights.
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From Knoxville McGhee Tyson to Chicago (CHI)
Search Deals
One-way flight from Knoxville McGhee Tyson to Chicago (CHI)
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($56 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals
Price to beat on a round-trip flight from Knoxville McGhee Tyson to Chicago (CHI).
Search Deals
Price to beat on a one-way flight from Knoxville McGhee Tyson to Chicago (CHI).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 4, 2026.
Use the filters below to find and compare flights from Knoxville to Chicago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Tue 6/23

6:55 pm-9:10 pm

1 stop3h 15m

Chicago Midway

Tue 6/30

9:00 am-5:00 pm

1 stop7h 00m

$249
Quickest round-trip

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 6/12

6:30 am-7:29 am

Nonstop1h 59m

Chicago O'Hare Intl

Sat 6/13

2:02 pm-4:51 pm

Nonstop1h 49m

$249

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 5/21

6:30 am-7:29 am

Nonstop1h 59m

Chicago O'Hare Intl

Tue 5/26

2:00 pm-5:00 pm

Nonstop2h 00m

$257

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Mon 7/6

7:17 pm-11:30 pm

1 stop5h 13m

Chicago O'Hare Intl

Sat 7/11

8:01 am-10:51 am

Nonstop1h 50m

$259

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Sat 5/23

5:35 pm-9:09 pm

1 stop4h 34m

Chicago Midway

Mon 5/25

6:23 am-11:09 am

1 stop3h 46m

$269

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Mon 7/6

7:45 pm-9:55 pm

1 stop3h 10m

Chicago Midway

Sat 7/11

3:30 pm-7:35 pm

1 stop3h 05m

$269

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 6/11

1:59 pm-6:42 pm

1 stop5h 43m

Chicago O'Hare Intl

Mon 6/15

5:30 am-11:09 am

1 stop4h 39m

$269

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 5/28

5:40 am-8:39 am

1 stop3h 59m

Chicago O'Hare Intl

Mon 6/1

5:30 am-1:10 pm

1 stop6h 40m

$269

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 7/3

7:35 am-12:36 pm

1 stop6h 01m

Chicago O'Hare Intl

Tue 7/7

6:35 am-1:16 pm

1 stop5h 41m

$269

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 6/25

3:59 pm-8:31 pm

1 stop5h 32m

Chicago O'Hare Intl

Sun 6/28

5:30 am-11:09 am

1 stop4h 39m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/3

Showing 1-10 of 40 resultsSorted by cheapest first
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Compare providers for flights from Knoxville to Chicago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Chicago in May.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
MytripPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Chicago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Chicago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Chicago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Chicago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Chicago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Chicago

How far ahead should I book a flight from Knoxville to Chicago?

The best time to book flights from Knoxville to Chicago is 70 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to Chicago?

Currently, November is the cheapest month in which you can book a flight from Knoxville to Chicago (average of $48). Flying from Knoxville to Chicago in March is currently the most expensive (average of $189). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CHI?

Find hourly flight availability from Knoxville to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 4, 2026.

It’s typically best to fly out from Knoxville to Chicago in the morning. Doing so could potentially save you 16% on the flight price compared to flying at noon, which is usually more expensive.

What is the cheapest day to fly from Knoxville to Chicago?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Chicago. Price data was last updated on April 25, 2026.

Travelers seeking maximum savings on their Knoxville to Chicago flight should consider departing on Wednesday at noon when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Knoxville to Chicago

Explore weekly flight availability from Knoxville to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated May 4, 2026.

The most flights from TYS to CHI are scheduled on a Sunday (33 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (11 on average).

How much does it cost to fly round-trip from Knoxville to Chicago?

Reviews of airlines servicing Chicago

Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated May 4, 2026.
Peruse reviews from past customers who have flown with United Airlines,Allegiant Air, andAmerican Airlines from Knoxville to Chicago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,681 reviews

Overall

7.4

Crew

8.1

Comfort

7.3

Entertainment

7.1

Boarding

7.7

Food

6.6

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
United Airlines
7.4
Good
9,681 reviews
United Airlines
7.4
Good
9,681 reviews

Overall

7.4

Crew

8.1

Comfort

7.3

Entertainment

7.1

Boarding

7.7

Food

6.6

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
Allegiant Air
7.3
Good
707 reviews
United Airlines
7.4
Good
9,681 reviews

Overall

7.4

Crew

8.1

Comfort

7.3

Entertainment

7.1

Boarding

7.7

Food

6.6

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
American Airlines
7.1
Good
11,670 reviews
United Airlines
7.4
Good
9,681 reviews

Overall

7.4

Crew

8.1

Comfort

7.3

Entertainment

7.1

Boarding

7.7

Food

6.6

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Chicago?

    If you book a flight to Chicago from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 25 flights from McGhee Tyson to Chicago per day from 3 different airlines.

  • How long is the flight from Knoxville to Chicago?

    There are many flights that can get you from Knoxville to Chicago in 1h 59m. Fly via Southwest, United Airlines, or American Airlines to get the fastest option. The distance from Knoxville to Chicago is about 475 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Knoxville to Chicago round-trip?

    Our cheapest airline available from Knoxville to Chicago is Allegiant Air. Our recent data shows that you can find tickets from as low as $60 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $189 and $189 round-trip. Allegiant Air is currently priced 77% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Knoxville to Chicago one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $49. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Knoxville to Chicago for a low price.

  • What are the most reliable airlines from Knoxville to Chicago?

    The top 3 most reliable airlines when flying from Knoxville to Chicago are ANA (73%), Japan Airlines (69%) and Air Canada (68%).

  • What are the cheapest flights from Knoxville to Chicago?

    On average you can expect to pay $812 for a flight from Knoxville to Chicago. The cheapest flight overall is $168 while the most popular route, (Knoxville McGhee Tyson - Chicago O'Hare Intl) is currently priced at $224.

  • Can I find deals for flights from Knoxville to Chicago that include hotel bookings?

    Yes. In addition to deals on Knoxville to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Chicago.

  • Can I find deals for business class flights from Knoxville to Chicago?

    Yes. Cheapflights offers flight deals from Knoxville to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Chicago?

    Currently, November is the cheapest month in which you can book a flight from Knoxville to Chicago (average of $48). Flying from Knoxville to Chicago in March is currently the most expensive (average of $189). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Benton Harbor
Lansing
Merrillville
Hammond
Porter

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Top 3 airlines flying from Knoxville to Chicago

Discover the top 3 airlines that operate flights from Knoxville to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$60Average$103FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$189Average$314FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$189Average$285FlexibilityNo cancel feeOn-time71%

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