$56+ Cheap flights from Knoxville (TYS) to Chicago (CHI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHI
Oct 18 — Oct 251
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Chicago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Chicago are usually found in January or April, booked 46 days in advance, depart on a Friday or Thursday and return on a Thursday
Cheap flight deals from Knoxville to Chicago
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Cheapest flights from Knoxville to ChicagoExplore the most affordable flight options available from Knoxville to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
Explore the most affordable flight options available from Knoxville to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2612:04 pm -
Nonstop1h 32m
Tue 10/279:53 am -
2 stops23h 12m
Deal found 9/15![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/58:55 am -
1 stop7h 42m
Sat 11/77:15 am -
2 stops27h 08m
Deal found 9/16![Multiple Airlines logo]()
$259
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:20 am -
2 stops5h 25m
Mon 11/28:45 am -
2 stops7h 05m
Deal found 9/14![Southwest logo]()
$262
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:25 pm -
1 stop5h 30m
Mon 10/196:30 pm -
1 stop3h 15m
Deal found 9/16![Southwest logo]()
$264
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:25 pm -
1 stop5h 30m
Tue 10/277:40 am -
1 stop3h 40m
Deal found 9/15![Southwest logo]()
$265
This Booking.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/238:00 am -
Nonstop1h 39m
Sun 11/293:27 pm -
Nonstop1h 27m
Deal found 9/13![Allegiant Air logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/129:33 pm -
2 stops27h 10m
Mon 10/261:26 pm -
Nonstop1h 25m
Deal found 9/14![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:05 am -
1 stop7h 25m
Mon 10/268:36 am -
1 stop12h 08m
Deal found 9/16![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:12 pm -
1 stop9h 31m
Thu 11/51:06 pm -
1 stop28h 00m
Deal found 9/15![Multiple Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:57 pm -
1 stop10h 42m
Mon 10/268:36 am -
1 stop12h 08m
Deal found 9/16![Multiple Airlines logo]()
$273
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:15 pm -
2 stops7h 35m
Wed 10/141:40 pm -
2 stops5h 30m
Deal found 9/16![Southwest logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:04 pm -
1 stop21h 26m
Mon 10/197:44 pm -
2 stops21h 30m
Deal found 9/15![Multiple Airlines logo]()
$278
Best flights from Knoxville to ChicagoDiscover carefully curated flight deals from Knoxville to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
Discover carefully curated flight deals from Knoxville to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:50 pm -
2 stops9h 00m
Mon 11/912:55 pm -
2 stops7h 50m
Deal found 9/17![Southwest logo]()
$262
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:00 am -
Nonstop1h 56m
Sun 10/116:03 pm -
Nonstop1h 46m
Deal found 9/15![United Airlines logo]()
$299
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:23 pm -
1 stop5h 10m
Sat 11/71:27 pm -
1 stop5h 22m
Deal found 9/14![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:10 pm -
1 stop6h 30m
Mon 11/96:41 am -
1 stop6h 01m
Deal found 9/17![American Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:25 pm -
1 stop5h 30m
Tue 10/272:45 pm -
2 stops5h 20m
Deal found 9/15![Southwest logo]()
$271
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:07 pm -
1 stop5h 47m
Mon 11/166:00 am -
1 stop4h 28m
Deal found 9/16![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/41:00 pm -
1 stop7h 35m
Sun 11/87:20 am -
1 stop6h 40m
Deal found 9/18![Southwest logo]()
$296
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:00 am -
Nonstop1h 56m
Sun 10/46:59 am -
Nonstop1h 46m
Deal found 9/14![United Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:17 pm -
1 stop5h 38m
Mon 1/185:25 pm -
1 stop5h 21m
Deal found 9/17![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:30 pm -
1 stop7h 50m
Sun 10/253:00 pm -
2 stops6h 45m
Deal found 9/16![Southwest logo]()
$297
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:28 pm -
1 stop4h 27m
Fri 1/16:00 am -
1 stop6h 38m
Deal found 9/13![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:45 am -
Nonstop2h 09m
Sun 11/296:55 am -
Nonstop1h 58m
Deal found 9/16![United Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:25 pm -
2 stops6h 45m
Mon 10/196:30 pm -
1 stop3h 15m
Deal found 9/14![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:45 am -
1 stop5h 41m
Sat 11/71:55 pm -
1 stop4h 54m
Deal found 9/14![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:30 am -
Nonstop2h 11m
Sat 1/27:15 am -
Nonstop1h 55m
Deal found 9/13![United Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:45 am -
1 stop5h 47m
Sat 11/71:55 pm -
1 stop4h 54m
Deal found 9/14![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/76:40 am -
Nonstop2h 10m
Mon 1/116:55 am -
Nonstop1h 55m
Deal found 9/15![United Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/178:25 am -
1 stop4h 55m
Fri 1/19:00 am -
1 stop3h 38m
Deal found 9/13![Delta logo]()
$319
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2511:43 am -
1 stop5h 35m
Mon 11/305:30 am -
1 stop4h 58m
Deal found 9/16![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:26 am -
1 stop3h 45m
Thu 11/55:27 am -
1 stop4h 18m
Deal found 9/14![Delta logo]()
$379
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:40 am -
1 stop4h 45m
Sat 11/71:55 pm -
1 stop4h 54m
Deal found 9/15![Delta logo]()
$379
Last-minute flights from Knoxville to ChicagoDiscover last-minute flight deals from Knoxville to Chicago. Data last updated September 18, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Chicago. Data last updated September 18, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:15 pm -
2 stops7h 35m
Wed 10/141:40 pm -
2 stops5h 30m
Deal found 9/16![Southwest logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:55 pm -
1 stop28h 44m
Wed 10/148:04 am -
2 stops33h 17m
Deal found 9/16![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/129:33 pm -
2 stops27h 10m
Mon 10/261:26 pm -
Nonstop1h 25m
Deal found 9/14![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:04 pm -
1 stop21h 26m
Mon 10/197:44 pm -
2 stops21h 30m
Deal found 9/15![Multiple Airlines logo]()
$278
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:25 pm -
1 stop5h 30m
Mon 10/196:30 pm -
1 stop3h 15m
Deal found 9/16![Southwest logo]()
$264
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:25 pm -
1 stop5h 30m
Fri 10/302:50 pm -
2 stops5h 45m
Deal found 9/15![Southwest logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:05 am -
1 stop7h 25m
Mon 10/268:36 am -
1 stop12h 08m
Deal found 9/16![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:57 pm -
1 stop10h 42m
Mon 10/268:36 am -
1 stop12h 08m
Deal found 9/16![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2612:04 pm -
Nonstop1h 32m
Tue 10/279:53 am -
2 stops23h 12m
Deal found 9/15![Multiple Airlines logo]()
$259
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:25 pm -
1 stop5h 30m
Tue 10/277:40 am -
1 stop3h 40m
Deal found 9/15![Southwest logo]()
$265
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:20 am -
2 stops5h 25m
Mon 11/28:45 am -
2 stops7h 05m
Deal found 9/14![Southwest logo]()
$262
This Kissandfly.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:23 pm -
1 stop5h 10m
Mon 11/21:26 pm -
Nonstop1h 25m
Deal found 9/17![Allegiant Air logo]()
$281
One-way flights from Knoxville to ChicagoSearch for one-way flight options from Knoxville to Chicago. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
Search for one-way flight options from Knoxville to Chicago. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:04 pm -
Nonstop1h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Allegiant Air logo]()
$56
This CheapOair deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:08 pm -
Nonstop1h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Allegiant Air logo]()
$62
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:04 pm -
1 stop21h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$83
This Flightnetwork deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:02 pm -
Nonstop1h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Allegiant Air logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/162:21 pm -
1 stop9h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:55 pm -
1 stop28h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:54 pm -
1 stop7h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$102
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/52:50 pm -
1 stop5h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Southwest logo]()
$106
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/102:55 pm -
1 stop7h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/144:14 pm -
1 stop24h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:15 am -
1 stop10h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:55 am -
1 stop7h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$117
Find flight deals from Knoxville to Chicago
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Chicago (CHI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $259 (Kiwi.com) |
One-way from | $56 (Kiwi.com) |
Popular in | March |
Cheapest in | January |
Average price | $353 |
Good round-trip deal | $358 or less |
Good one-way deal | $291 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
Use the filters below to find and compare flights from Knoxville to Chicago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Sat 12/5
2:50 pm-7:35 pm
1 stop5h 45m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$106
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Sat 10/31
6:40 am-1:15 pm
2 stops7h 35m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$111
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Mon 10/19
7:25 pm-11:55 pm
1 stop5h 30m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$160
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Mon 10/5
7:25 pm-11:55 pm
1 stop5h 30m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$175
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Fri 10/9
7:25 pm-11:55 pm
1 stop5h 30m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$176
Quickest round-trip
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Mon 10/5
11:34 am-12:06 pm
Nonstop1h 32m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$184
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Fri 10/30
9:28 pm-5:47 pm
2 stops21h 19m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$188
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Mon 10/12
7:25 pm-11:55 pm
1 stop5h 30m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$200
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Fri 10/16
5:30 pm-12:20 am
1 stop7h 50m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$204
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Wed 12/23
12:40 pm-8:20 pm
2 stops8h 40m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$210
Showing 1-10 of 42 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Chicago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Chicago in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Chicago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Chicago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Chicago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Chicago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Chicago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Chicago
Have a flexible travel schedule? Discover the best time to fly to Chicago from Knoxville with our price prediction graph.
TYS-CHI
TYS-MDW
TYS-ORD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Chicago
TYS-CHI
TYS-MDW
TYS-ORD
What is the cheapest month to book a flight from Knoxville to Chicago?
Currently, January is the cheapest month in which you can book a flight from Knoxville to Chicago (average of $236). Flying from Knoxville to Chicago in September is currently the most expensive (average of $349). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from TYS to CHI?
Find hourly flight availability from Knoxville to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 18, 2026.
It’s typically best to fly out from Knoxville to Chicago in the morning. Doing so could potentially save you 35% on the flight price compared to flying at noon, which is usually more expensive.
Weekly flight availability from Knoxville to Chicago
Explore weekly flight availability from Knoxville to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 18, 2026.
The most flights from TYS to CHI are scheduled on a Thursday (34 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (23 on average).
How much does it cost to fly round-trip from Knoxville to Chicago?
Airfare is typical for this route at the moment.
Knoxville to Chicago flights typically cost between $259 and $418 in October.The cheapest round-trip price found within the last 5 days was $259 on Multiple Airlines (Oct 26-Oct 27).
How far ahead should I book a flight from Knoxville to Chicago?
The best time to book flights from Knoxville to Chicago is 45 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest day to fly from Knoxville to Chicago?
Use this chart to determine the cheapest time to fly round-trip from Knoxville to Chicago. Price data was last updated on September 12, 2026.
Travelers seeking maximum savings on their Knoxville to Chicago flight should consider departing on Monday afternoons when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing Chicago
Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated September 18, 2026.
Peruse reviews from past customers who have flown with United Airlines,Allegiant Air, andAmerican Airlines from Knoxville to Chicago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.4
Boarding
7.7
Crew
8.1
Comfort
7.3
Entertainment
7.1
Food
6.7
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Overall
7.4
Boarding
7.7
Crew
8.1
Comfort
7.3
Entertainment
7.1
Food
6.7
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Overall
7.4
Boarding
7.7
Crew
8.1
Comfort
7.3
Entertainment
7.1
Food
6.7
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Overall
7.4
Boarding
7.7
Crew
8.1
Comfort
7.3
Entertainment
7.1
Food
6.7
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Chicago?
Book flights to Chicago if you plan to visit one of these locationsBenton Harbor
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Hammond
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Knoxville and Chicago flights
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Top 3 airlines flying from Knoxville to Chicago
Discover the top 3 airlines that operate flights from Knoxville to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$79 | Average$133 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$189 | Average$329 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$189 | Average$322 | FlexibilityNo cancel fee | On-time71% |