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$173+ Cheap flights from Florence, SC (FLO) to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/8. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — CHI
Jun 3 — Jun 101
Wed 6/3
Wed 6/10
1 adult, Economy
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1. Tell us where you want to go

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Cheap flight deals from Florence to Chicago

Cheapest flights from Florence to Chicago
Explore the most affordable flight options available from Florence to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 4, 2026.

This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:20 am
FLO
-
ORD
1 stop6h 24m
American Airlines
Wed 5/203:26 pm
ORD
-
FLO
1 stop5h 21m
American Airlines
Deal found 5/1$339
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:15 am
FLO
-
ORD
1 stop7h 21m
American Airlines
Sat 5/235:00 am
ORD
-
FLO
2 stops8h 10m
American Airlines
Deal found 5/4$344
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:20 am
FLO
-
ORD
1 stop4h 10m
American Airlines
Tue 5/198:39 am
ORD
-
FLO
1 stop5h 53m
American Airlines
Deal found 4/30$380
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:35 pm
FLO
-
ORD
1 stop6h 13m
American Airlines
Sun 5/317:58 am
ORD
-
FLO
1 stop5h 12m
American Airlines
Deal found 4/30$382
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/24:16 pm
FLO
-
ORD
1 stop4h 06m
American Airlines
Wed 5/63:26 pm
ORD
-
FLO
1 stop5h 21m
American Airlines
Deal found 5/1$419
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/24:16 pm
FLO
-
ORD
2 stops7h 31m
American Airlines
Tue 5/56:00 am
ORD
-
FLO
2 stops8h 32m
American Airlines
Deal found 5/1$429
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:05 am
FLO
-
ORD
1 stop4h 57m
American Airlines
Mon 5/256:55 am
ORD
-
FLO
1 stop6h 15m
American Airlines
Deal found 5/2$437
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:20 am
FLO
-
ORD
1 stop6h 24m
American Airlines
Thu 5/216:55 am
ORD
-
FLO
1 stop6h 15m
American Airlines
Deal found 5/2$439

Find flight deals from Florence to Chicago

Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to Chicago (CHI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$339
(American Airlines)

One-way from

$173
(American Airlines)
Provider with most accurate pricing for Florence-Chicago (CHI) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-Chicago (CHI) flights.
Search Deals
From Florence to Chicago (CHI)
Search Deals
One-way flight from Florence to Chicago (CHI)
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 4, 2026.
Use the filters below to find and compare flights from Florence to Chicago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceChicago

FLO - ORD

FLOORD

Florence

Tue 5/19

6:15 am-10:11 am

1 stop4h 56m

Chicago O'Hare Intl

Sat 5/23

7:58 am-2:10 pm

1 stop5h 12m

$339

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sat 5/16

5:20 am-10:44 am

1 stop6h 24m

Chicago O'Hare Intl

Wed 5/20

3:26 pm-9:47 pm

1 stop5h 21m

$339
Quickest round-trip

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 5/15

5:20 am-8:30 am

1 stop4h 10m

Chicago O'Hare Intl

Tue 5/19

8:39 am-3:32 pm

1 stop5h 53m

$380

FlorenceChicago

FLO - ORD

FLOORD

Florence

Thu 5/28

5:05 am-9:02 am

1 stop4h 57m

Chicago O'Hare Intl

Sun 5/31

5:00 am-2:10 pm

2 stops8h 10m

$387

FlorenceChicago

FLO - ORD

FLOORD

Florence

Thu 5/21

5:05 am-9:02 am

1 stop4h 57m

Chicago O'Hare Intl

Mon 5/25

6:55 am-2:10 pm

1 stop6h 15m

$437

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sun 5/17

5:20 am-10:44 am

1 stop6h 24m

Chicago O'Hare Intl

Thu 5/21

6:55 am-2:10 pm

1 stop6h 15m

$439

FlorenceChicago

FLO - ORD

FLOORD

Florence

Mon 6/1

5:05 am-11:32 am

2 stops7h 27m

Chicago O'Hare Intl

Sun 6/7

5:00 am-2:10 pm

2 stops8h 10m

$599
Cheapest one-way
Quickest one-way

FlorenceChicago

FLO - ORD

FLOORD

Florence

Mon 6/8

2:35 pm-7:45 pm

1 stop6h 10m

$173

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/3

Sorted by cheapest first

Compare providers for flights from Florence to Chicago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Florence to Chicago in May.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Florence, South Carolina-Chicago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-Chicago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-Chicago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Florence, South Carolina-Chicago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-Chicago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Florence to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Chicago
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Florence to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Chicago?

    Florence (FLO) is the airport you will fly out of if you book a flight from Florence to Chicago. You should not have trouble finding flights to Chicago from Florence; the airport handles an average of 0 outbound flights to Chicago per day. You should also have plenty of airline options to choose from since 1 airline has flights from the Florence airport to Chicago. It is only a 2.3 mi journey to Florence (FLO) from Florence’s city center.

  • How long is the flight from Florence, South Carolina to Chicago?

    A quick flight from Florence, South Carolina to Chicago can take about 4h 56m. American Airlines provides one of the quickest options available for as low as $339. Airlines will cover a distance of 697 mi.

  • Can I find deals for flights from Florence to Chicago that include hotel bookings?

    Yes. In addition to deals on Florence to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Chicago.

  • Can I find deals for business class flights from Florence to Chicago?

    Yes. Cheapflights offers flight deals from Florence to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
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Lansing
Merrillville
Hammond
Porter

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Top airline flying from Florence to Chicago

Discover the top airline that operate flights from Florence to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$176Average$336FlexibilityNo cancel feeOn-time71%

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