$375+ Cheap flights from Florence, SC (FLO) to Chicago (CHI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/2. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — CHI
Oct 4 — Oct 111
Round-trip
1 adult, Economy
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Find cheap flights from Florence to Chicago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Florence to Chicago
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Last-minute
Cheapest flights from Florence to ChicagoExplore the most affordable flight options available from Florence to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 4, 2026.
Explore the most affordable flight options available from Florence to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 4, 2026.
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/23:37 pm -
1 stop4h 59m
Sat 12/59:00 am -
1 stop5h 09m
Deal found 8/31![American Airlines logo]()
$375
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:37 pm -
1 stop4h 59m
Sat 11/214:58 pm -
1 stop5h 56m
Deal found 8/31![American Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/152:34 pm -
1 stop6h 17m
Sun 10/189:02 am -
1 stop4h 07m
Deal found 9/3![American Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:43 pm -
1 stop6h 55m
Thu 9/248:05 am -
1 stop4h 13m
Deal found 9/1![American Airlines logo]()
$465
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:43 pm -
1 stop4h 55m
Wed 9/238:05 am -
1 stop4h 13m
Deal found 9/4![American Airlines logo]()
$469
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:22 am -
1 stop5h 29m
Sat 9/51:22 pm -
1 stop6h 58m
Deal found 8/30![American Airlines logo]()
$488
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:22 am -
1 stop5h 29m
Fri 9/45:49 pm -
1 stop4h 10m
Deal found 9/1![American Airlines logo]()
$507
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:09 am -
1 stop4h 50m
Sat 12/52:55 pm -
2 stops7h 04m
Deal found 9/2![American Airlines logo]()
$606
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:24 am -
2 stops6h 52m
Sun 9/206:45 am -
1 stop6h 25m
Deal found 9/1![American Airlines logo]()
$649
Best flights from Florence to ChicagoDiscover carefully curated flight deals from Florence to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 4, 2026.
Discover carefully curated flight deals from Florence to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 4, 2026.
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/23:37 pm -
1 stop4h 59m
Sat 12/59:00 am -
1 stop5h 09m
Deal found 8/31![American Airlines logo]()
$375
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/15:09 am -
1 stop4h 50m
Fri 12/48:05 am -
1 stop5h 05m
Deal found 8/31![American Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/152:34 pm -
1 stop6h 17m
Sun 10/189:02 am -
1 stop4h 07m
Deal found 9/3![American Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:24 am -
1 stop5h 21m
Sun 9/276:45 am -
1 stop6h 25m
Deal found 9/1![American Airlines logo]()
$465
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:43 pm -
1 stop6h 55m
Thu 9/248:05 am -
1 stop4h 13m
Deal found 9/1![American Airlines logo]()
$465
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:43 pm -
1 stop4h 55m
Wed 9/238:05 am -
1 stop4h 13m
Deal found 9/4![American Airlines logo]()
$469
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/161:43 pm -
1 stop4h 55m
Sun 9/208:05 am -
1 stop5h 05m
Deal found 9/1![American Airlines logo]()
$488
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:24 am -
1 stop6h 50m
Mon 9/215:20 am -
1 stop6h 58m
Deal found 9/1![American Airlines logo]()
$507
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/252:35 pm -
1 stop6h 28m
Fri 11/276:29 am -
2 stops6h 40m
Deal found 8/31![American Airlines logo]()
$659
Last-minute flights from Florence to ChicagoDiscover last-minute flight deals from Florence to Chicago. Data last updated September 4, 2026 and is based on user searches.
Discover last-minute flight deals from Florence to Chicago. Data last updated September 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:22 am -
1 stop5h 29m
Sat 9/51:22 pm -
1 stop6h 58m
Deal found 8/30![American Airlines logo]()
$488
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:22 am -
1 stop5h 29m
Fri 9/45:49 pm -
1 stop4h 10m
Deal found 9/1![American Airlines logo]()
$507
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:24 am -
2 stops6h 52m
Sun 9/206:45 am -
1 stop6h 25m
Deal found 9/1![American Airlines logo]()
$649
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:24 am -
2 stops7h 26m
Mon 9/214:45 pm -
1 stop5h 13m
Deal found 9/1![American Airlines logo]()
$714
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:43 pm -
1 stop4h 55m
Wed 9/238:05 am -
1 stop4h 13m
Deal found 9/4![American Airlines logo]()
$469
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:43 pm -
1 stop6h 55m
Thu 9/248:05 am -
1 stop4h 13m
Deal found 9/1![American Airlines logo]()
$465
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:24 am -
1 stop6h 50m
Sun 9/276:29 am -
2 stops6h 41m
Deal found 9/1![American Airlines logo]()
$704
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/152:34 pm -
1 stop6h 17m
Sun 10/189:02 am -
1 stop4h 07m
Deal found 9/3![American Airlines logo]()
$409
Find flight deals from Florence to Chicago
Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to Chicago (CHI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $375 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Florence to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 4, 2026.
Use the filters below to find and compare flights from Florence to Chicago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
FlorenceChicago
FLO Florence - ORD Chicago O'Hare Intl
FLOORD
Florence
Wed 12/2
3:37 pm-7:36 pm
1 stop4h 59m
Chicago O'Hare Intl
Sat 12/5
9:00 am-3:09 pm
1 stop5h 09m
$375
FlorenceChicago
FLO Florence - ORD Chicago O'Hare Intl
FLOORD
Florence
Tue 12/1
5:09 am-8:59 am
1 stop4h 50m
Chicago O'Hare Intl
Fri 12/4
8:05 am-2:10 pm
1 stop5h 05m
$387
FlorenceChicago
FLO Florence - ORD Chicago O'Hare Intl
FLOORD
Florence
Thu 10/15
2:34 pm-7:51 pm
1 stop6h 17m
Chicago O'Hare Intl
Sun 10/18
9:02 am-2:09 pm
1 stop4h 07m
$409
FlorenceChicago
FLO Florence - ORD Chicago O'Hare Intl
FLOORD
Florence
Thu 9/24
6:24 am-10:45 am
1 stop5h 21m
Chicago O'Hare Intl
Sun 9/27
6:45 am-2:10 pm
1 stop6h 25m
$465
FlorenceChicago
FLO Florence - ORD Chicago O'Hare Intl
FLOORD
Florence
Wed 9/23
1:43 pm-7:38 pm
1 stop6h 55m
Chicago O'Hare Intl
Thu 9/24
8:05 am-1:18 pm
1 stop4h 13m
$465
Quickest round-trip
FlorenceChicago
FLO Florence - ORD Chicago O'Hare Intl
FLOORD
Florence
Sat 9/19
1:43 pm-5:38 pm
1 stop4h 55m
Chicago O'Hare Intl
Wed 9/23
8:05 am-1:18 pm
1 stop4h 13m
$469
FlorenceChicago
FLO Florence - ORD Chicago O'Hare Intl
FLOORD
Florence
Wed 9/16
1:43 pm-5:38 pm
1 stop4h 55m
Chicago O'Hare Intl
Sun 9/20
8:05 am-2:10 pm
1 stop5h 05m
$488
FlorenceChicago
FLO Florence - ORD Chicago O'Hare Intl
FLOORD
Florence
Thu 9/17
6:24 am-12:14 pm
1 stop6h 50m
Chicago O'Hare Intl
Mon 9/21
5:20 am-1:18 pm
1 stop6h 58m
$507
FlorenceChicago
FLO Florence - ORD Chicago O'Hare Intl
FLOORD
Florence
Wed 11/25
2:35 pm-8:03 pm
1 stop6h 28m
Chicago O'Hare Intl
Fri 11/27
6:29 am-2:09 pm
2 stops6h 40m
$659
Sorted by cheapest first
Compare providers for flights from Florence to Chicago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Florence to Chicago in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Florence, South Carolina-Chicago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-Chicago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-Chicago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Florence, South Carolina-Chicago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-Chicago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Florence to Chicago
Have a flexible travel schedule? Discover the best time to fly to Chicago from Florence with our price prediction graph.
FLO-CHI
FLO-ORD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Florence to Chicago
FLO-CHI
FLO-ORD
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Florence to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Chicago?
Book flights to Chicago if you plan to visit one of these locationsBenton Harbor
Lansing
Merrillville
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Hammond
Saint Joseph
Porter
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