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$209+ Cheap flights from Florence, SC (FLO) to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/7. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — CHI
Aug 25 — Sep 11
Mon 8/25
Mon 9/1
1 adult, Economy
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Cheap flight deals from Florence to Chicago

Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to Chicago (CHI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 20, 2025.

Round-trip from

$417
(American Airlines)

One-way from

$209
(American Airlines)
From Florence to Chicago (CHI)
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One-way flight from Florence to Chicago (CHI)
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Find flight deals from Florence to Chicago

Cheapest flights from Florence to Chicago
Explore the most affordable flight options available from Florence to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.

This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/212:11 pmFLO - ORD
1 stop5h 37mAmerican Airlines
Sat 9/69:51 amORD - FLO
1 stop6h 21mAmerican Airlines
Deal found 8/18$417
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/412:27 pmFLO - ORD
2 stops7h 01mAmerican Airlines
Mon 9/83:33 pmORD - FLO
2 stops6h 43mAmerican Airlines
Deal found 8/20$427

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Florence to Chicago that are best for you.

Fly from

Florence

Fly to

Chicago

Route

Depart

Return

Price

FlorenceChicago

FLO - ORD

FLOORD

Florence

Tue 9/2

12:11 pm-4:48 pm

1 stop5h 37m

Chicago O'Hare Intl

Sat 9/6

9:51 am-5:12 pm

1 stop6h 21m

$417

FlorenceChicago

FLO - ORD

FLOORD

Florence

Thu 9/4

6:14 am-10:43 am

1 stop5h 29m

Chicago O'Hare Intl

Mon 9/8

5:08 pm-11:16 pm

1 stop5h 08m

$417

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sun 9/7

5:14 am-10:47 am

1 stop6h 33m

$209

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/19

Best time to book a flight from Florence to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Chicago

What is the cheapest month to book a flight from Florence, South Carolina to Chicago?

Currently, August is the cheapest month in which you can book a flight from Florence, South Carolina to Chicago (average of $245). Flying from Florence, South Carolina to Chicago in March is currently the most expensive (average of $321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Chicago?

    Florence (FLO) is the airport you will fly out of if you book a flight from Florence to Chicago. You should not have trouble finding flights to Chicago from Florence; the airport handles an average of 0 outbound flights to Chicago per day. You should also have plenty of airline options to choose from since 1 airline has flights from the Florence airport to Chicago. It is only a 2.3 mi journey to Florence (FLO) from Florence’s city center.

  • How long is the flight from Florence, South Carolina to Chicago?

    A quick flight from Florence, South Carolina to Chicago can take about 5h 37m. American Airlines provides one of the quickest options available for as low as $417. Airlines will cover a distance of 697 mi.

  • Can I find deals for flights from Florence to Chicago that include hotel bookings?

    Yes. In addition to deals on Florence to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Chicago.

  • Can I find deals for business class flights from Florence to Chicago?

    Yes. Cheapflights offers flight deals from Florence to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Chicago?

    Currently, August is the cheapest month in which you can book a flight from Florence, South Carolina to Chicago (average of $245). Flying from Florence, South Carolina to Chicago in March is currently the most expensive (average of $321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
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Hammond
Benton Harbor
Porter
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Top airline flying from Florence to Chicago

Discover the top airline that operate flights from Florence to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$176Average$372FlexibilityNo cancel feeOn-time71%

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