$144+ Cheap flights from Knoxville to Charleston (TYS - CHS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Nov 13 — Nov 201
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Charleston with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Charleston
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Best
Last-minute
One-way
Cheapest flights from Knoxville to CharlestonExplore the most affordable flight options available from Knoxville to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2026.
Explore the most affordable flight options available from Knoxville to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2026.
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:19 pm -
1 stop3h 45m
Mon 11/167:26 pm -
1 stop3h 22m
Deal found 10/9![American Airlines logo]()
$287
This Southwest deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:55 am -
1 stop4h 50m
Tue 11/178:00 am -
2 stops11h 50m
Deal found 10/11![Southwest logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:00 am -
1 stop25h 38m
Fri 10/308:58 pm -
2 stops13h 07m
Deal found 10/13![Multiple Airlines logo]()
$298
This Delta deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/44:01 pm -
1 stop4h 05m
Sun 12/66:19 am -
1 stop3h 42m
Deal found 10/12![Delta logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:08 pm -
1 stop25h 06m
Mon 11/168:58 pm -
2 stops20h 20m
Deal found 10/9![Multiple Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:05 am -
2 stops12h 55m
Sun 12/67:40 am -
2 stops12h 50m
Deal found 10/12![Southwest logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:05 am -
1 stop7h 06m
Mon 10/268:58 pm -
2 stops20h 16m
Deal found 10/10![Multiple Airlines logo]()
$341
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:37 pm -
1 stop27h 24m
Thu 11/192:13 pm -
1 stop21h 35m
Deal found 10/13![Multiple Airlines logo]()
$357
Best flights from Knoxville to CharlestonDiscover carefully curated flight deals from Knoxville to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 14, 2026.
Discover carefully curated flight deals from Knoxville to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 14, 2026.
This Delta deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/76:00 am -
1 stop3h 42m
Sat 1/912:15 pm -
1 stop2h 50m
Deal found 10/9![Delta logo]()
$287
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:19 pm -
1 stop3h 45m
Mon 11/167:26 pm -
1 stop3h 22m
Deal found 10/9![American Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:08 pm -
1 stop25h 06m
Mon 11/168:58 pm -
2 stops20h 20m
Deal found 10/9![Multiple Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/166:40 am -
2 stops9h 10m
Tue 3/236:30 am -
1 stop6h 10m
Deal found 10/11![Southwest logo]()
$372
This Delta deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/44:01 pm -
1 stop4h 05m
Sun 12/66:19 am -
1 stop3h 42m
Deal found 10/12![Delta logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:00 am -
1 stop25h 38m
Fri 10/304:57 pm -
1 stop17h 08m
Deal found 10/13![Multiple Airlines logo]()
$324
This Delta deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/235:30 am -
1 stop3h 10m
Fri 3/267:59 pm -
1 stop3h 47m
Deal found 10/11![Delta logo]()
$367
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:33 pm -
2 stops47h 57m
Thu 11/192:13 pm -
1 stop21h 35m
Deal found 10/13![Multiple Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:55 am -
2 stops11h 40m
Mon 11/1611:00 am -
2 stops9h 50m
Deal found 10/9![Southwest logo]()
$443
This Delta deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/255:30 am -
1 stop4h 12m
Sun 3/287:59 pm -
1 stop3h 47m
Deal found 10/13![Delta logo]()
$387
This Southwest deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/236:55 am -
2 stops9h 05m
Fri 3/266:20 am -
1 stop5h 40m
Deal found 10/11![Southwest logo]()
$452
Last-minute flights from Knoxville to CharlestonDiscover last-minute flight deals from Knoxville to Charleston. Data last updated October 14, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Charleston. Data last updated October 14, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:05 am -
1 stop7h 06m
Mon 10/268:58 pm -
2 stops20h 16m
Deal found 10/10![Multiple Airlines logo]()
$341
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:00 am -
1 stop25h 38m
Fri 10/308:58 pm -
2 stops13h 07m
Deal found 10/13![Multiple Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:19 pm -
1 stop3h 45m
Mon 11/167:26 pm -
1 stop3h 22m
Deal found 10/9![American Airlines logo]()
$287
This Southwest deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:55 am -
1 stop4h 50m
Tue 11/178:00 am -
2 stops11h 50m
Deal found 10/11![Southwest logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:08 pm -
1 stop25h 06m
Mon 11/168:58 pm -
2 stops20h 20m
Deal found 10/9![Multiple Airlines logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:37 pm -
1 stop27h 24m
Thu 11/192:13 pm -
1 stop21h 35m
Deal found 10/13![Multiple Airlines logo]()
$357
One-way flights from Knoxville to CharlestonSearch for one-way flight options from Knoxville to Charleston. Find affordable one-way fares based on user searches. Data last updated October 14, 2026.
Search for one-way flight options from Knoxville to Charleston. Find affordable one-way fares based on user searches. Data last updated October 14, 2026.
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:22 pm -
1 stop4h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Delta logo]()
$144
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:25 pm -
2 stops14h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Southwest logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/131:17 pm -
3 stops24h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Multiple Airlines logo]()
$231
Find flight deals from Knoxville to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $287 (American Airlines) |
Popular in | November |
Cheapest in | September |
Average price | $517 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 14, 2026.
Use the filters below to find and compare flights from Knoxville to Charleston that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Fri 11/13
7:25 pm-10:05 am
2 stops14h 40m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$155
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Fri 11/13
1:17 pm-1:24 pm
3 stops24h 07m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$231
Quickest round-trip
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Thu 1/7
6:00 am-9:42 am
1 stop3h 42m
Charleston
Sat 1/9
12:15 pm-3:05 pm
1 stop2h 50m
$287
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Tue 11/10
5:19 pm-9:04 pm
1 stop3h 45m
Charleston
Mon 11/16
7:26 pm-10:48 pm
1 stop3h 22m
$287
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Fri 12/4
4:01 pm-8:06 pm
1 stop4h 05m
Charleston
Sun 12/6
6:19 am-10:01 am
1 stop3h 42m
$313
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Tue 11/10
6:08 pm-7:14 pm
1 stop25h 06m
Charleston
Mon 11/16
8:58 pm-5:18 pm
2 stops20h 20m
$322
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Mon 10/26
7:00 am-8:38 am
1 stop25h 38m
Charleston
Fri 10/30
4:57 pm-10:05 am
1 stop17h 08m
$324
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Tue 3/23
5:30 am-8:40 am
1 stop3h 10m
Charleston
Fri 3/26
7:59 pm-11:46 pm
1 stop3h 47m
$367
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Thu 11/12
6:33 pm-6:30 pm
2 stops47h 57m
Charleston
Thu 11/19
2:13 pm-11:48 am
1 stop21h 35m
$371
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Tue 3/16
6:40 am-3:50 pm
2 stops9h 10m
Charleston
Tue 3/23
6:30 am-12:40 pm
1 stop6h 10m
$372
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Charleston
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Charleston in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from Knoxville with our price prediction graph.
TYS-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Charleston
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated October 14, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Charleston to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.8
Food
7.2
Comfort
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Boarding
8.1
Entertainment
7.8
Food
7.2
Comfort
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Boarding
8.1
Entertainment
7.8
Food
7.2
Comfort
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Summerville
Walterboro
Mount Pleasant
Goose Creek
Edisto Beach
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Other flights to Charleston
Explore flights to Charleston departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 14, 2026.
Complete your trip
Complete your trip to Charleston by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Knoxville to Charleston, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Charleston flights
Browse other Knoxville and Charleston flight options. Last updated on October 14, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on October 14, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Charleston
Discover the top 2 airlines that operate flights from Knoxville to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$289 | Average$548 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$318 | Average$427 | FlexibilityNo cancel fee | On-timeN/A |