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$92+ Cheap flights from Knoxville to Charleston (TYS - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
oct. 11 — oct. 181
sáb. 10/11
sáb. 10/18
1 adult, Economy
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Cheap flight deals from Knoxville to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 11, 2025.

Round-trip from

$183
(American Airlines)

One-way from

$92
(American Airlines)

Popular in

December

Cheapest in

August

Average price

$366
From Knoxville McGhee Tyson to Charleston
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One-way flight from Knoxville McGhee Tyson to Charleston
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Highest demand for flights based on searches. 17% potential increase in price ($93 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Charleston

Cheapest flights from Knoxville to Charleston
Explore the most affordable flight options available from Knoxville to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/215:00 amTYS - CHS
1 stop6h 35mAmerican Airlines
sáb. 10/257:43 pmCHS - TYS
1 stop4h 07mAmerican Airlines
Deal found 9/10$183
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/255:55 pmTYS - CHS
1 stop15h 10mMultiple Airlines
lun. 9/2910:10 amCHS - TYS
1 stop6h 27mMultiple Airlines
Deal found 9/10$225
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/257:00 amTYS - CHS
1 stop3h 49mAmerican Airlines
lun. 10/277:43 pmCHS - TYS
1 stop4h 07mAmerican Airlines
Deal found 9/11$235
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/238:37 pmTYS - CHS
1 stop3h 28mAmerican Airlines
sáb. 10/257:43 pmCHS - TYS
1 stop4h 07mAmerican Airlines
Deal found 9/11$236
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/306:51 pmTYS - CHS
1 stop14h 06mMultiple Airlines
mar. 11/47:55 pmCHS - TYS
2 stops46h 27mMultiple Airlines
Deal found 9/9$258
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/244:31 pmTYS - CHS
1 stop18h 14mMultiple Airlines
dom. 9/2812:08 pmCHS - TYS
1 stop28h 29mMultiple Airlines
Deal found 9/9$273
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/114:26 pmTYS - CHS
1 stop16h 40mMultiple Airlines
lun. 10/1310:11 amCHS - TYS
1 stop24h 22mMultiple Airlines
Deal found 9/10$285
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/247:43 pmTYS - CHS
1 stop3h 25mAmerican Airlines
dom. 10/265:00 amCHS - TYS
1 stop4h 32mAmerican Airlines
Deal found 9/10$289
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/99:15 pmTYS - CHS
1 stop11h 51mMultiple Airlines
dom. 10/199:38 pmCHS - TYS
2 stops36h 55mMultiple Airlines
Deal found 9/9$307
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/248:10 pmTYS - CHS
1 stop3h 49mDelta
dom. 10/265:35 amCHS - TYS
1 stop3h 45mDelta
Deal found 9/9$308

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
Use the filters below to find and compare flights from Knoxville to Charleston that are best for you.

Fly from

Knoxville

Fly to

Charleston

Route

Depart

Return

Price

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

sáb. 10/25

7:00 am-10:49 am

1 stop3h 49m

Charleston

lun. 10/27

7:43 pm-11:50 pm

1 stop4h 07m

$235

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

jue. 10/23

8:37 pm-12:05 am

1 stop3h 28m

Charleston

sáb. 10/25

7:43 pm-11:50 pm

1 stop4h 07m

$236

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

vie. 11/7

5:07 pm-11:59 pm

1 stop6h 52m

Charleston

mar. 11/11

6:10 am-11:46 am

1 stop5h 36m

$285

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

vie. 10/24

7:43 pm-11:08 pm

1 stop3h 25m

Charleston

dom. 10/26

5:00 am-9:32 am

1 stop4h 32m

$289

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

vie. 10/24

7:15 am-6:13 pm

1 stop10h 58m

Charleston

dom. 10/26

7:10 pm-7:32 pm

2 stops24h 22m

$320

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

sáb. 9/27

5:45 am-11:48 am

1 stop6h 03m

Charleston

mié. 10/1

6:20 am-9:44 am

1 stop3h 24m

$328

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

vie. 9/26

4:13 pm-3:24 pm

2 stops23h 11m

Charleston

lun. 9/29

10:10 am-4:37 pm

1 stop6h 27m

$328

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

jue. 10/23

9:15 pm-9:06 am

1 stop11h 51m

Charleston

sáb. 10/25

7:55 pm-2:42 pm

2 stops18h 47m

$335

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

vie. 11/7

9:09 pm-10:45 am

1 stop13h 36m

Charleston

mar. 11/11

5:30 pm-3:42 pm

2 stops22h 12m

$346

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

mié. 10/8

7:15 am-6:41 pm

1 stop11h 26m

Charleston

vie. 10/10

10:11 am-10:18 am

1 stop24h 07m

$347

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Showing 1-10 of 17 results
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Best time to book a flight from Knoxville to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Charleston

What is the cheapest month to book a flight from Knoxville to Charleston?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Charleston (average of $217). Flying from Knoxville to Charleston in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CHS?

Find hourly flight availability from Knoxville to Charleston. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 11, 2025.

When flying from Knoxville to Charleston, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 19% versus a flight in the afternoon.

How much does it cost to fly round-trip from Knoxville to Charleston?

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated septiembre 11, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Charleston to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Charleston?

    A quick flight from Knoxville to Charleston can take about 3h 49m. American Airlines provides one of the quickest options available for as low as $235. The distance between Knoxville and Charleston is about 302 mi.

  • What are the cheapest airlines flying from Knoxville to Charleston round-trip?

    Currently priced at $316, Delta will fly you from Knoxville to Charleston and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $331. You may be able to fly from Knoxville to Charleston for 29% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Charleston that include hotel bookings?

    Yes. In addition to deals on Knoxville to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Charleston.

  • Can I find deals for business class flights from Knoxville to Charleston?

    Yes. Cheapflights offers flight deals from Knoxville to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Charleston?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Charleston (average of $217). Flying from Knoxville to Charleston in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Summerville
Walterboro
Mount Pleasant
Isle of Palms
Santee
Edisto Beach

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Top 2 airlines flying from Knoxville to Charleston

Discover the top 2 airlines that operate flights from Knoxville to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$316Average$468FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$331Average$466FlexibilityNo cancel feeOn-time71%

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