$189+ Cheap flights from Knoxville to Charleston (TYS - CHS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/5. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Jul 15 — Jul 221
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Charleston with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Charleston
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Best
Last-minute
One-way
Cheapest flights from Knoxville to CharlestonExplore the most affordable flight options available from Knoxville to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
Explore the most affordable flight options available from Knoxville to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:00 am
TYS
- CHS
1 stop26h 38m
Multiple Airlines
Fri 7/109:44 pm
CHS
- TYS
1 stop25h 13m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:20 pm
TYS
- CHS
1 stop13h 18m
Multiple Airlines
Fri 7/103:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:20 pm
TYS
- CHS
1 stop13h 28m
Multiple Airlines
Fri 7/173:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$255
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2811:57 am
TYS
- CHS
1 stop3h 56m
Delta
Tue 8/45:10 am
CHS
- TYS
1 stop6h 01m
Delta
Deal found 6/13![Delta logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:20 pm
TYS
- CHS
1 stop13h 28m
Multiple Airlines
Mon 7/133:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:20 pm
TYS
- CHS
1 stop13h 28m
Multiple Airlines
Mon 7/133:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/144:20 pm
TYS
- CHS
1 stop16h 48m
Multiple Airlines
Fri 7/173:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$274
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/288:10 am
TYS
- CHS
2 stops12h 20m
Southwest
Tue 8/48:10 am
CHS
- TYS
2 stops10h 45m
Southwest
Deal found 6/13![Southwest logo]()
$275
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:40 am
TYS
- CHS
1 stop3h 18m
Delta
Mon 8/102:17 pm
CHS
- TYS
1 stop5h 53m
Delta
Deal found 6/15![Delta logo]()
$281
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:45 am
TYS
- CHS
1 stop2h 56m
Delta
Mon 9/217:13 pm
CHS
- TYS
1 stop4h 37m
Delta
Deal found 6/11![Delta logo]()
$287
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3011:01 am
TYS
- CHS
1 stop3h 40m
American Airlines
Fri 7/36:17 pm
CHS
- TYS
1 stop5h 34m
American Airlines
Deal found 6/11![American Airlines logo]()
$295
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:54 pm
TYS
- CHS
1 stop6h 13m
Delta
Mon 7/137:59 pm
CHS
- TYS
1 stop3h 53m
Delta
Deal found 6/12![Delta logo]()
$301
Best flights from Knoxville to CharlestonDiscover carefully curated flight deals from Knoxville to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
Discover carefully curated flight deals from Knoxville to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/288:10 am
TYS
- CHS
2 stops12h 20m
Southwest
Tue 8/41:25 pm
CHS
- TYS
1 stop6h 25m
Southwest
Deal found 6/13![Southwest logo]()
$270
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:40 am
TYS
- CHS
1 stop3h 18m
Delta
Mon 8/102:17 pm
CHS
- TYS
1 stop5h 53m
Delta
Deal found 6/15![Delta logo]()
$281
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3011:01 am
TYS
- CHS
1 stop3h 40m
American Airlines
Fri 7/36:17 pm
CHS
- TYS
1 stop5h 34m
American Airlines
Deal found 6/11![American Airlines logo]()
$295
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:54 pm
TYS
- CHS
1 stop6h 13m
Delta
Mon 7/137:59 pm
CHS
- TYS
1 stop3h 53m
Delta
Deal found 6/12![Delta logo]()
$301
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:10 am
TYS
- CHS
2 stops14h 20m
Southwest
Fri 7/174:10 pm
CHS
- TYS
1 stop6h 25m
Southwest
Deal found 6/12![Southwest logo]()
$312
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:45 pm
TYS
- CHS
1 stop3h 48m
Delta
Mon 9/215:25 am
CHS
- TYS
1 stop4h 14m
Delta
Deal found 6/15![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1812:35 pm
TYS
- CHS
2 stops9h 50m
Southwest
Thu 10/221:15 pm
CHS
- TYS
2 stops7h 45m
Southwest
Deal found 6/14![Southwest logo]()
$319
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:25 am
TYS
- CHS
1 stop7h 00m
Southwest
Mon 9/217:00 am
CHS
- TYS
2 stops12h 55m
Southwest
Deal found 6/15![Southwest logo]()
$320
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/78:10 am
TYS
- CHS
2 stops12h 20m
Southwest
Mon 7/1310:35 am
CHS
- TYS
2 stops10h 40m
Southwest
Deal found 6/10![Southwest logo]()
$332
Last-minute flights from Knoxville to CharlestonDiscover last-minute flight deals from Knoxville to Charleston. Data last updated June 15, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Charleston. Data last updated June 15, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3011:01 am
TYS
- CHS
1 stop3h 40m
American Airlines
Fri 7/36:17 pm
CHS
- TYS
1 stop5h 34m
American Airlines
Deal found 6/11![American Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:20 pm
TYS
- CHS
1 stop13h 28m
Multiple Airlines
Mon 7/133:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:00 am
TYS
- CHS
1 stop26h 38m
Multiple Airlines
Fri 7/109:44 pm
CHS
- TYS
1 stop25h 13m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:20 pm
TYS
- CHS
1 stop13h 18m
Multiple Airlines
Fri 7/103:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$246
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:54 pm
TYS
- CHS
1 stop6h 13m
Delta
Mon 7/137:59 pm
CHS
- TYS
1 stop3h 53m
Delta
Deal found 6/12![Delta logo]()
$301
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/78:10 am
TYS
- CHS
2 stops12h 20m
Southwest
Mon 7/136:25 am
CHS
- TYS
1 stop5h 35m
Southwest
Deal found 6/12![Southwest logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:20 pm
TYS
- CHS
1 stop13h 28m
Multiple Airlines
Fri 7/173:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:20 pm
TYS
- CHS
1 stop13h 28m
Multiple Airlines
Mon 7/133:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/144:20 pm
TYS
- CHS
1 stop16h 48m
Multiple Airlines
Fri 7/173:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$274
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2811:57 am
TYS
- CHS
1 stop3h 56m
Delta
Tue 8/45:10 am
CHS
- TYS
1 stop6h 01m
Delta
Deal found 6/13![Delta logo]()
$265
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/288:10 am
TYS
- CHS
2 stops12h 20m
Southwest
Tue 8/48:10 am
CHS
- TYS
2 stops10h 45m
Southwest
Deal found 6/13![Southwest logo]()
$275
One-way flights from Knoxville to CharlestonSearch for one-way flight options from Knoxville to Charleston. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
Search for one-way flight options from Knoxville to Charleston. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/57:46 pm
TYS
- CHS
1 stop3h 38m
Delta
Deal found 6/12![Delta logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/271:19 pm
TYS
- CHS
3 stops43h 19m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$192
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/612:35 pm
TYS
- CHS
2 stops9h 25m
Southwest
Deal found 6/12![Southwest logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/53:38 pm
TYS
- CHS
3 stops55h 09m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/512:45 pm
TYS
- CHS
2 stops9h 05m
Southwest
Deal found 6/12![Southwest logo]()
$274
Find flight deals from Knoxville to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $241 (Kiwi.com) |
One-way from | $148 (American Airlines) |
Popular in | January |
Cheapest in | August |
Average price | $531 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Knoxville to Charleston that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Tue 7/28
8:10 am-8:30 pm
2 stops12h 20m
Charleston
Tue 8/4
1:25 pm-7:50 pm
1 stop6h 25m
$270
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Thu 8/6
5:40 am-8:58 am
1 stop3h 18m
Charleston
Mon 8/10
2:17 pm-8:10 pm
1 stop5h 53m
$281
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Tue 6/30
11:01 am-2:41 pm
1 stop3h 40m
Charleston
Fri 7/3
6:17 pm-11:51 pm
1 stop5h 34m
$295
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Tue 7/7
3:54 pm-10:07 pm
1 stop6h 13m
Charleston
Mon 7/13
7:59 pm-11:52 pm
1 stop3h 53m
$301
Quickest round-trip
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Fri 9/11
5:45 pm-9:33 pm
1 stop3h 48m
Charleston
Mon 9/21
5:25 am-9:39 am
1 stop4h 14m
$309
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Tue 7/14
7:10 am-9:30 pm
2 stops14h 20m
Charleston
Fri 7/17
4:10 pm-10:35 pm
1 stop6h 25m
$312
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Sun 10/18
12:35 pm-10:25 pm
2 stops9h 50m
Charleston
Thu 10/22
1:15 pm-9:00 pm
2 stops7h 45m
$319
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Fri 9/11
8:25 am-3:25 pm
1 stop7h 00m
Charleston
Mon 9/21
7:00 am-7:55 pm
2 stops12h 55m
$320
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Tue 7/7
8:10 am-8:30 pm
2 stops12h 20m
Charleston
Mon 7/13
10:35 am-9:15 pm
2 stops10h 40m
$332
Cheapest one-way
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Sun 9/27
4:57 pm-8:48 am
1 stop15h 51m
$199
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Charleston
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Charleston in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from Knoxville with our price prediction graph.
TYS-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Charleston
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated June 15, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Charleston to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Entertainment
7.8
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Entertainment
7.8
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Entertainment
7.8
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Goose Creek
Edisto Beach
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Alternative routes for Knoxville to Charleston
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Other flights to Charleston
Explore flights to Charleston departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 15, 2026.
Complete your trip
Complete your trip to Charleston by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Charleston by cabin class
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Knoxville and Charleston flights
Browse other Knoxville and Charleston flight options. Last updated on June 15, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on June 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Charleston
Discover the top 2 airlines that operate flights from Knoxville to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$279 | Average$525 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$412 | FlexibilityNo cancel fee | On-timeN/A |