$339+ Cheap flights from Des Moines (DSM) to Biloxi, MS
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MSY
Oct 17 — Oct 241
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Biloxi
Cheapest
Best
Last-minute
Cheapest flights from Des Moines to BiloxiExplore the most affordable flight options available from Des Moines to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
Explore the most affordable flight options available from Des Moines to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/102:59 pm -
1 stop6h 53m
Sat 11/146:20 am -
1 stop4h 31m
Deal found 9/16![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:26 am -
2 stops11h 26m
Sat 11/146:20 am -
2 stops10h 29m
Deal found 9/16![Delta logo]()
$394
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
1 stop5h 18m
Mon 10/55:14 pm -
1 stop5h 01m
Deal found 9/16![United Airlines logo]()
$400
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:12 pm -
1 stop6h 45m
Tue 10/2011:47 am -
1 stop7h 13m
Deal found 9/15![American Airlines logo]()
$404
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1811:31 am -
1 stop5h 43m
Sun 9/206:25 am -
1 stop4h 21m
Deal found 9/12![Delta logo]()
$444
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/242:13 pm -
2 stops8h 19m
Fri 10/26:22 pm -
1 stop4h 50m
Deal found 9/16![American Airlines logo]()
$549
Best flights from Des Moines to BiloxiDiscover carefully curated flight deals from Des Moines to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
Discover carefully curated flight deals from Des Moines to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/112:59 pm -
1 stop6h 53m
Sat 11/1410:04 am -
1 stop5h 17m
Deal found 9/16![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/268:00 am -
1 stop8h 02m
Sat 1/305:15 pm -
1 stop5h 15m
Deal found 9/13![United Airlines logo]()
$419
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/102:59 pm -
1 stop6h 53m
Sat 11/146:20 am -
1 stop4h 31m
Deal found 9/16![Delta logo]()
$339
Last-minute flights from Des Moines to BiloxiDiscover last-minute flight deals from Des Moines to Biloxi. Data last updated September 17, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Biloxi. Data last updated September 17, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1811:31 am -
1 stop5h 43m
Mon 9/215:59 pm -
1 stop4h 27m
Deal found 9/12![Delta logo]()
$444
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:00 am -
2 stops11h 14m
Sun 9/206:25 am -
1 stop4h 21m
Deal found 9/12![Delta logo]()
$449
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/242:13 pm -
2 stops8h 19m
Fri 10/26:22 pm -
1 stop4h 50m
Deal found 9/16![American Airlines logo]()
$549
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
1 stop5h 18m
Mon 10/55:14 pm -
1 stop5h 01m
Deal found 9/16![United Airlines logo]()
$400
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:12 pm -
1 stop6h 45m
Sun 10/186:42 pm -
1 stop5h 16m
Deal found 9/14![American Airlines logo]()
$649
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:12 pm -
1 stop6h 45m
Tue 10/2011:47 am -
1 stop7h 13m
Deal found 9/15![American Airlines logo]()
$404
Find flight deals from Des Moines to Biloxi
Keep the following information in mind while searching for Des Moines to Biloxi flight deals. Data was last updated September 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $339 (Delta) |
One-way from | $229 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
Use the filters below to find and compare flights from Des Moines to Biloxi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesGulfport
DSM Des Moines - GPT Gulfport Biloxi Regional
DSMGPT
Des Moines
Wed 11/11
2:59 pm-9:52 pm
1 stop6h 53m
Gulfport Biloxi Regional
Sat 11/14
10:04 am-3:21 pm
1 stop5h 17m
$339
Quickest round-trip
Des MoinesGulfport
DSM Des Moines - GPT Gulfport Biloxi Regional
DSMGPT
Des Moines
Tue 11/10
2:59 pm-9:52 pm
1 stop6h 53m
Gulfport Biloxi Regional
Sat 11/14
6:20 am-10:51 am
1 stop4h 31m
$339
Des MoinesGulfport
DSM Des Moines - GPT Gulfport Biloxi Regional
DSMGPT
Des Moines
Tue 1/26
8:00 am-4:02 pm
1 stop8h 02m
Gulfport Biloxi Regional
Sat 1/30
5:15 pm-10:30 pm
1 stop5h 15m
$419
Sorted by cheapest first
Best time to book a flight from Des Moines to Biloxi
Have a flexible travel schedule? Discover the best time to fly to Biloxi from Des Moines with our price prediction graph.
DSM-GPT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Biloxi
DSM-B1L
DSM-GPT
What is the cheapest time of day to fly from DSM to B1L?
Find hourly flight availability from Des Moines to Biloxi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Biloxi as you normally would.
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Biloxi
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Complete your trip
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Des Moines and Biloxi flights
Browse other Des Moines and Biloxi flight options. Last updated on September 17, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 17, 2026.
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Des Moines to Biloxi flights
Consider these flights traveling from Des Moines to Biloxi.
Top 5 airlines flying from Des Moines to Biloxi
Discover the top 5 airlines that operate flights from Des Moines to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$129 | Average$217 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$258 | Average$386 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$258 | Average$432 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$290 | Average$433 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$312 | Average$392 | FlexibilityNo cancel fee | On-time63% |