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Biloxi

$206+ Cheap flights from Des Moines (DSM) to Biloxi, MS

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MSY
Jun 27 — Jul 41
Sat 6/27
Sat 7/4
1 adult, Economy
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Cheap flight deals from Des Moines to Biloxi

Cheapest flights from Des Moines to Biloxi
Explore the most affordable flight options available from Des Moines to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 28, 2026.

This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/114:48 pm
DSM
-
GPT
1 stop6h 09m
American Airlines
Sat 7/186:35 pm
GPT
-
DSM
1 stop5h 34m
American Airlines
Deal found 5/27$309
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/35:12 am
DSM
-
GPT
1 stop5h 43m
American Airlines
Sat 8/85:53 pm
GPT
-
DSM
1 stop5h 55m
American Airlines
Deal found 5/27$393
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:40 am
DSM
-
GPT
1 stop7h 23m
Delta
Fri 8/146:00 pm
GPT
-
DSM
1 stop4h 37m
Delta
Deal found 5/27$459
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/165:12 am
DSM
-
GPT
1 stop5h 43m
American Airlines
Sun 7/196:35 pm
GPT
-
DSM
1 stop5h 34m
American Airlines
Deal found 5/23$487
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/169:33 pm
DSM
-
GPT
1 stop19h 18m
Multiple Airlines
Sun 7/197:25 pm
GPT
-
DSM
2 stops21h 15m
Multiple Airlines
Deal found 5/23$491
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:30 am
DSM
-
GPT
1 stop5h 22m
American Airlines
Sat 7/116:35 pm
GPT
-
DSM
1 stop5h 34m
American Airlines
Deal found 5/27$500
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:30 am
DSM
-
GPT
1 stop5h 22m
American Airlines
Mon 6/1511:23 am
GPT
-
DSM
1 stop6h 59m
American Airlines
Deal found 5/27$517
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/298:00 am
DSM
-
GPT
2 stops11h 38m
United Airlines
Tue 9/14:59 pm
GPT
-
DSM
1 stop5h 31m
United Airlines
Deal found 5/26$550
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/35:12 am
DSM
-
GPT
1 stop5h 43m
American Airlines
Sun 8/95:53 pm
GPT
-
DSM
1 stop5h 55m
American Airlines
Deal found 5/27$553

Find flight deals from Des Moines to Biloxi

Keep the following information in mind while searching for Des Moines to Biloxi flight deals. Data was last updated May 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$309
(American Airlines)

One-way from

$206
(Delta)

Popular in

March

Cheapest in

July

Average price

$431
Provider with most accurate pricing for Des Moines-Gulfport Biloxi Regional flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Gulfport Biloxi Regional flights.
Search Deals
From Des Moines to Biloxi
Search Deals
One-way flight from Des Moines to Biloxi
Search Deals
Highest demand for flights based on searches. 26% potential increase in price ($132 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($28 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 28, 2026.
Use the filters below to find and compare flights from Des Moines to Biloxi that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Thu 7/16

9:33 pm-4:51 pm

1 stop19h 18m

Gulfport Biloxi Regional

Sun 7/19

7:25 pm-4:40 pm

2 stops21h 15m

$491
Quickest round-trip

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sat 7/11

4:48 pm-10:57 pm

1 stop6h 09m

Gulfport Biloxi Regional

Sat 7/18

6:35 pm-12:09 am

1 stop5h 34m

$514

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sat 8/29

6:00 am-4:12 pm

2 stops10h 12m

Gulfport Biloxi Regional

Tue 9/1

4:59 pm-10:30 pm

1 stop5h 31m

$550

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Wed 6/10

1:33 pm-11:59 pm

2 stops10h 26m

Gulfport Biloxi Regional

Sun 6/14

6:32 pm-12:12 am

1 stop5h 40m

$567
Cheapest one-way

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Tue 6/16

11:28 am-5:11 pm

1 stop5h 43m

$206
Quickest one-way

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Tue 6/23

5:30 am-10:52 am

1 stop5h 22m

$206

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Tue 6/23

2:54 pm-7:10 pm

3 stops52h 16m

$374

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/24

Sorted by cheapest first

Best time to book a flight from Des Moines to Biloxi

Have a flexible travel schedule? Discover the best time to fly to Biloxi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Biloxi

What is the cheapest time of day to fly from DSM to B1L?

Find hourly flight availability from Des Moines to Biloxi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 28, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Biloxi as you normally would.

How much does it cost to fly round-trip from Des Moines to Biloxi?

Reviews of airlines servicing Biloxi

Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated May 28, 2026.
Read reviews from past customers who have flown United Airlines and American Airlines from Des Moines to Biloxi. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,751 reviews

Entertainment

7.1

Food

6.6

Boarding

7.7

Comfort

7.3

Crew

8.1

Overall

7.4

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.
United Airlines
7.4
Good
9,751 reviews
United Airlines
7.4
Good
9,751 reviews

Entertainment

7.1

Food

6.6

Boarding

7.7

Comfort

7.3

Crew

8.1

Overall

7.4

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.
American Airlines
7.1
Good
11,639 reviews
United Airlines
7.4
Good
9,751 reviews

Entertainment

7.1

Food

6.6

Boarding

7.7

Comfort

7.3

Crew

8.1

Overall

7.4

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Biloxi?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Biloxi from Des Moines. Booking flights from Des Moines (DSM) to Biloxi should be relatively easy as there are 0 daily outbound flights to Biloxi from 5 different airlines.

  • How long is the flight from Des Moines to Biloxi?

    American Airlines and United Airlines can get you from Des Moines to Biloxi in just under 6h 09m. Your travel time can differ by up to 4h 03m. Des Moines and Biloxi are separated by a distance of 810 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Des Moines to Biloxi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Biloxi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Biloxi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Biloxi.

  • Can I find deals for business class flights from Des Moines to Biloxi?

    Yes. Cheapflights offers flight deals from Des Moines to Biloxi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top 5 airlines flying from Des Moines to Biloxi

Discover the top 5 airlines that operate flights from Des Moines to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$129Average$218FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$216Average$383FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$435FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$258Average$367FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$270Average$387FlexibilityNo cancel feeOn-time63%

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