HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Biloxi

$184+ Cheap flights from Des Moines (DSM) to Biloxi, MS

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MSY
Aug 29 — Sep 51
Sat 8/29
Sat 9/5
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Biloxi with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Biloxi

Cheapest flights from Des Moines to Biloxi
Explore the most affordable flight options available from Des Moines to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.

This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:22 pm
DSM
-
GPT
1 stop4h 54m
American Airlines
Wed 8/266:34 pm
GPT
-
DSM
1 stop4h 51m
American Airlines
Deal found 7/29$319
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am
DSM
-
GPT
2 stops10h 12m
United Airlines
Sat 9/54:59 pm
GPT
-
DSM
1 stop5h 31m
United Airlines
Deal found 7/28$344
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:00 am
DSM
-
GPT
2 stops10h 12m
United Airlines
Wed 8/262:00 pm
GPT
-
DSM
2 stops9h 44m
United Airlines
Deal found 7/29$349
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1311:28 am
DSM
-
GPT
1 stop5h 47m
American Airlines
Sun 11/155:40 pm
GPT
-
DSM
1 stop6h 17m
American Airlines
Deal found 7/27$379
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/306:00 am
DSM
-
GPT
2 stops10h 12m
United Airlines
Sat 9/54:59 pm
GPT
-
DSM
1 stop5h 31m
United Airlines
Deal found 7/29$389
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/14:48 pm
DSM
-
GPT
1 stop6h 09m
American Airlines
Tue 8/46:35 pm
GPT
-
DSM
1 stop5h 34m
American Airlines
Deal found 7/28$424
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/274:48 pm
DSM
-
GPT
1 stop6h 09m
American Airlines
Fri 8/76:34 pm
GPT
-
DSM
1 stop4h 51m
American Airlines
Deal found 7/25$439
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:22 pm
DSM
-
GPT
1 stop4h 54m
American Airlines
Fri 9/46:34 pm
GPT
-
DSM
1 stop4h 51m
American Airlines
Deal found 7/29$458
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/306:11 pm
DSM
-
GPT
1 stop5h 48m
American Airlines
Thu 9/36:34 pm
GPT
-
DSM
1 stop4h 56m
American Airlines
Deal found 7/28$471
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/254:14 pm
DSM
-
GPT
1 stop7h 10m
American Airlines
Sun 9/275:35 am
GPT
-
DSM
1 stop5h 37m
American Airlines
Deal found 7/29$478
This Delta deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2711:30 am
DSM
-
GPT
1 stop5h 42m
Delta
Fri 8/710:01 am
GPT
-
DSM
2 stops10h 38m
Delta
Deal found 7/25$482

Find flight deals from Des Moines to Biloxi

Keep the following information in mind while searching for Des Moines to Biloxi flight deals. Data was last updated July 30, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(American Airlines)

One-way from

$184
(American Airlines)

Popular in

March

Cheapest in

December

Average price

$308
Provider with most accurate pricing for Des Moines-Gulfport Biloxi Regional flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Gulfport Biloxi Regional flights.
Search Deals
From Des Moines to Biloxi
Search Deals
One-way flight from Des Moines to Biloxi
Search Deals
Highest demand for flights based on searches. 32% potential increase in price ($198 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 14% potential price decrease ($51 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
Use the filters below to find and compare flights from Des Moines to Biloxi that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Fri 8/21

6:22 pm-11:16 pm

1 stop4h 54m

Gulfport Biloxi Regional

Wed 8/26

6:34 pm-11:25 pm

1 stop4h 51m

$319

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Fri 8/21

2:54 pm-10:21 pm

1 stop7h 27m

Gulfport Biloxi Regional

Wed 8/26

1:48 pm-8:39 pm

2 stops6h 51m

$344

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Tue 9/1

6:00 am-4:12 pm

2 stops10h 12m

Gulfport Biloxi Regional

Sat 9/5

4:59 pm-10:30 pm

1 stop5h 31m

$344

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Wed 1/6

8:00 am-1:26 pm

1 stop5h 26m

Gulfport Biloxi Regional

Sat 1/9

5:15 pm-10:30 pm

1 stop5h 15m

$462

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Fri 11/13

1:58 pm-11:57 pm

2 stops9h 59m

Gulfport Biloxi Regional

Sun 11/15

5:40 pm-11:57 pm

1 stop6h 17m

$504

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sun 8/30

2:28 pm-11:59 pm

2 stops9h 31m

Gulfport Biloxi Regional

Thu 9/3

6:34 pm-11:30 pm

1 stop4h 56m

$575

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Fri 1/8

6:15 am-4:02 pm

2 stops9h 47m

Gulfport Biloxi Regional

Mon 1/11

5:15 pm-10:30 pm

1 stop5h 15m

$587

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sun 8/30

6:00 am-4:12 pm

2 stops10h 12m

Gulfport Biloxi Regional

Sat 9/5

2:00 pm-11:44 pm

2 stops9h 44m

$601

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sun 8/16

6:11 pm-11:59 pm

1 stop5h 48m

Gulfport Biloxi Regional

Wed 8/19

1:50 pm-12:20 am

2 stops10h 30m

$621
Cheapest one-way
Quickest one-way

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Fri 9/11

6:24 am-4:12 pm

2 stops9h 48m

$225

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Showing 1-10 of 11 resultsSorted by cheapest first
1
2

Best time to book a flight from Des Moines to Biloxi

Have a flexible travel schedule? Discover the best time to fly to Biloxi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Biloxi

What is the cheapest time of day to fly from DSM to B1L?

Find hourly flight availability from Des Moines to Biloxi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 30, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Biloxi as you normally would.

Reviews of airlines servicing Biloxi

Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated July 30, 2026.
Read reviews from past customers who have flown American Airlines from Des Moines to Biloxi. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,842 reviews

Comfort

7.2

Entertainment

6.8

Boarding

7.5

Crew

7.9

Food

6.4

Overall

7.1

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go
American Airlines
7.1
Good
11,842 reviews
American Airlines
7.1
Good
11,842 reviews

Comfort

7.2

Entertainment

6.8

Boarding

7.5

Crew

7.9

Food

6.4

Overall

7.1

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Biloxi?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Biloxi from Des Moines. Booking flights from Des Moines (DSM) to Biloxi should be relatively easy as there are 0 daily outbound flights to Biloxi from 5 different airlines.

  • How long is the flight from Des Moines to Biloxi?

    American Airlines, Delta, and United Airlines can get you from Des Moines to Biloxi in just under 4h 54m. Your travel time can differ by up to 5h 18m. Des Moines and Biloxi are separated by a distance of 810 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Des Moines to Biloxi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Biloxi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Biloxi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Biloxi.

  • Can I find deals for business class flights from Des Moines to Biloxi?

    Yes. Cheapflights offers flight deals from Des Moines to Biloxi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 5 airlines flying from Des Moines to Biloxi

Discover the top 5 airlines that operate flights from Des Moines to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$132Average$220FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$248Average$406FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$258Average$360FlexibilityNo cancel feeOn-time69%
DeltaCheapest$276Average$416FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$277Average$402FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.