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Biloxi

$264+ Cheap flights from Des Moines (DSM) to Biloxi, MS

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MSY
May 10 — May 171
Sun 5/10
Sun 5/17
1 adult, Economy
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Cheap flight deals from Des Moines to Biloxi

Cheapest flights from Des Moines to Biloxi
Explore the most affordable flight options available from Des Moines to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 10, 2026.

This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:00 am
DSM
-
GPT
1 stop5h 33m
American Airlines
Tue 5/126:18 am
GPT
-
DSM
1 stop6h 34m
American Airlines
Deal found 4/5$320
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:16 pm
DSM
-
GPT
2 stops9h 42m
American Airlines
Tue 4/285:00 am
GPT
-
DSM
1 stop6h 26m
American Airlines
Deal found 4/8$364
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:58 pm
DSM
-
GPT
1 stop4h 55m
United Airlines
Mon 5/184:55 pm
GPT
-
DSM
1 stop5h 50m
United Airlines
Deal found 4/7$376
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/83:20 pm
DSM
-
GPT
1 stop7h 31m
American Airlines
Tue 4/146:03 am
GPT
-
DSM
1 stop6h 49m
American Airlines
Deal found 4/7$431
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1311:57 am
DSM
-
GPT
1 stop5h 17m
Delta
Mon 5/186:02 pm
GPT
-
DSM
1 stop4h 30m
Delta
Deal found 4/8$459
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:44 am
DSM
-
GPT
2 stops11h 49m
American Airlines
Mon 5/185:03 pm
GPT
-
DSM
1 stop6h 56m
American Airlines
Deal found 4/8$495

Find flight deals from Des Moines to Biloxi

Keep the following information in mind while searching for Des Moines to Biloxi flight deals. Data was last updated April 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$320
(American Airlines)

One-way from

$264
(American Airlines)

Popular in

March

Cheapest in

August
Provider with most accurate pricing for Des Moines-Gulfport Biloxi Regional flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Gulfport Biloxi Regional flights.
Search Deals
From Des Moines to Biloxi
Search Deals
One-way flight from Des Moines to Biloxi
Search Deals
Highest demand for flights based on searches. 25% potential increase in price ($128 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($28 potential savings vs. average RT price).
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
Use the filters below to find and compare flights from Des Moines to Biloxi that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sat 5/2

12:03 pm-11:58 pm

2 stops11h 55m

Gulfport Biloxi Regional

Tue 5/12

6:18 am-12:52 pm

1 stop6h 34m

$325
Quickest round-trip

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Wed 5/13

6:15 am-4:13 pm

2 stops9h 58m

Gulfport Biloxi Regional

Mon 5/18

4:55 pm-10:45 pm

1 stop5h 50m

$477

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Fri 4/24

11:09 am-11:58 pm

2 stops12h 49m

Gulfport Biloxi Regional

Sun 4/26

6:00 am-1:11 pm

1 stop7h 11m

$524

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Tue 4/28

5:30 am-2:13 pm

2 stops8h 43m

Gulfport Biloxi Regional

Sat 5/2

7:07 am-4:15 pm

2 stops9h 08m

$553

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Thu 4/23

5:00 am-10:33 am

1 stop5h 33m

Gulfport Biloxi Regional

Mon 4/27

12:42 pm-11:49 pm

2 stops11h 07m

$688
Cheapest one-way
Quickest one-way

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sun 4/26

5:00 am-10:33 am

1 stop5h 33m

$264

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sun 4/26

8:30 am-9:00 am

3 stops24h 30m

$285

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Wed 5/20

2:33 pm-9:51 pm

1 stop7h 18m

$294

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Wed 5/20

2:24 pm-11:58 pm

2 stops9h 34m

$338

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/4

Sorted by cheapest first

Best time to book a flight from Des Moines to Biloxi

Have a flexible travel schedule? Discover the best time to fly to Biloxi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Biloxi

What is the cheapest month to book a flight from Des Moines to Biloxi?

Currently, November is the cheapest month in which you can book a flight from Des Moines to Biloxi (average of $100). Flying from Des Moines to Biloxi in May is currently the most expensive (average of $253). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to B1L?

Find hourly flight availability from Des Moines to Biloxi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 10, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Biloxi as you normally would.

Reviews of airlines servicing Biloxi

Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated April 10, 2026.
Read reviews from past customers who have flown American Airlines from Des Moines to Biloxi. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,564 reviews

Overall

7.1

Entertainment

6.8

Comfort

7.2

Boarding

7.5

Food

6.4

Crew

7.9

Reviews

1 / 20
4.0
Okay

Elizabeth,Mar 2026

ORD - MIA

Staff was rude and flight attendants 2 out of 3 looked like they had just been thru a hurricane.
American Airlines
7.1
Good
11,564 reviews
American Airlines
7.1
Good
11,564 reviews

Overall

7.1

Entertainment

6.8

Comfort

7.2

Boarding

7.5

Food

6.4

Crew

7.9

Reviews

1 / 20
4.0
Okay

Elizabeth,Mar 2026

ORD - MIA

Staff was rude and flight attendants 2 out of 3 looked like they had just been thru a hurricane.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Biloxi?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Biloxi from Des Moines. Booking flights from Des Moines (DSM) to Biloxi should be relatively easy as there are 0 daily outbound flights to Biloxi from 5 different airlines.

  • How long is the flight from Des Moines to Biloxi?

    American Airlines and United Airlines can get you from Des Moines to Biloxi in just under 9h 58m. Your travel time can differ by up to 1h 57m. Des Moines and Biloxi are separated by a distance of 810 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Des Moines to Biloxi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Biloxi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Biloxi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Biloxi.

  • Can I find deals for business class flights from Des Moines to Biloxi?

    Yes. Cheapflights offers flight deals from Des Moines to Biloxi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Biloxi?

    Currently, November is the cheapest month in which you can book a flight from Des Moines to Biloxi (average of $100). Flying from Des Moines to Biloxi in May is currently the most expensive (average of $253). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 5 airlines flying from Des Moines to Biloxi

Discover the top 5 airlines that operate flights from Des Moines to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$126Average$219FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$236Average$408FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$435FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$258Average$360FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$270Average$392FlexibilityNo cancel feeOn-time63%

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