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Biloxi

$234+ Cheap flights from Des Moines (DSM) to Biloxi, MS

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MSY
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Des Moines to Biloxi

Keep the following information in mind while searching for Des Moines to Biloxi flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$364
(American Airlines)

One-way from

$234
(American Airlines)

Popular in

February

Cheapest in

August

Average price

$370
Provider with most accurate pricing for Des Moines-Gulfport Biloxi Regional flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Gulfport Biloxi Regional flights.
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From Des Moines to Biloxi
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One-way flight from Des Moines to Biloxi
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Highest demand for flights based on searches. 17% potential increase in price ($79 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($25 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Des Moines to Biloxi

Cheapest flights from Des Moines to Biloxi
Explore the most affordable flight options available from Des Moines to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/145:04 pmDSM - GPT
1 stop5h 40mAmerican Airlines
Sun 11/165:20 amGPT - DSM
1 stop5h 20mAmerican Airlines
Deal found 10/29$364
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:05 amDSM - GPT
1 stop7h 15mUnited Airlines
Sun 11/309:51 pmGPT - DSM
1 stop24h 29mUnited Airlines
Deal found 10/28$559
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/256:05 amDSM - GPT
1 stop7h 15mUnited Airlines
Sun 11/309:51 pmGPT - DSM
1 stop24h 29mUnited Airlines
Deal found 10/27$592
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/254:03 pmDSM - GPT
1 stop7h 54mAmerican Airlines
Sun 11/305:20 amGPT - DSM
1 stop5h 20mAmerican Airlines
Deal found 10/28$596
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:39 amDSM - GPT
1 stop5h 39mAmerican Airlines
Sun 11/305:20 amGPT - DSM
1 stop5h 20mAmerican Airlines
Deal found 10/29$667
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/222:52 pmDSM - GPT
1 stop20h 25mUnited Airlines
Sat 11/297:00 amGPT - DSM
1 stop7h 11mUnited Airlines
Deal found 10/29$677

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Des Moines to Biloxi that are best for you.

Fly from

Des Moines

Fly to

Biloxi

Route

Depart

Return

Price

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Fri 11/14

5:04 pm-10:44 pm

1 stop5h 40m

Gulfport Biloxi Regional

Sun 11/16

5:20 am-10:40 am

1 stop5h 20m

$364

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Tue 11/25

6:05 am-1:20 pm

1 stop7h 15m

Gulfport Biloxi Regional

Sun 11/30

9:51 pm-10:20 pm

1 stop24h 29m

$592

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Tue 11/25

4:03 pm-11:57 pm

1 stop7h 54m

Gulfport Biloxi Regional

Sun 11/30

5:20 am-10:40 am

1 stop5h 20m

$596

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Thu 11/27

6:39 am-12:18 pm

1 stop5h 39m

Gulfport Biloxi Regional

Sun 11/30

5:20 am-10:40 am

1 stop5h 20m

$667

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sat 11/22

2:52 pm-11:17 am

1 stop20h 25m

Gulfport Biloxi Regional

Sat 11/29

7:00 am-2:11 pm

1 stop7h 11m

$677

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Fri 12/5

5:04 pm-10:33 pm

1 stop5h 29m

$234

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Fri 12/5

6:17 am-2:08 pm

2 stops7h 51m

$239

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Fri 12/5

8:00 am-1:20 pm

3 stops29h 20m

$412

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Best time to book a flight from Des Moines to Biloxi

Have a flexible travel schedule? Discover the best time to fly to Biloxi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Biloxi

What is the cheapest month to book a flight from Des Moines to Biloxi?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Biloxi (average of $126). Flying from Des Moines to Biloxi in June is currently the most expensive (average of $331). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to B1L?

Find hourly flight availability from Des Moines to Biloxi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

A simple way to save on the total cost of your ticket is to fly from Des Moines to Biloxi in the evening. If you’re flexible enough to do this you can expect to save up to 49% on your trip compared to booking a flight at noon.

How much does it cost to fly round-trip from Des Moines to Biloxi?

Reviews of airlines servicing Biloxi

Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated October 30, 2025.
Read reviews from past customers who have flown American Airlines from Des Moines to Biloxi. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,034 reviews

Overall

7.2

Boarding

7.5

Food

6.4

Crew

8.0

Entertainment

6.9

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
11,034 reviews
American Airlines
7.2
Good
11,034 reviews

Overall

7.2

Boarding

7.5

Food

6.4

Crew

8.0

Entertainment

6.9

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Biloxi?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Biloxi from Des Moines. Booking flights from Des Moines (DSM) to Biloxi should be relatively easy as there are 0 daily outbound flights to Biloxi from 5 different airlines.

  • How long is the flight from Des Moines to Biloxi?

    American Airlines and United Airlines can get you from Des Moines to Biloxi in just under 5h 40m. Your travel time can differ by up to 1h 35m. Des Moines and Biloxi are separated by a distance of 810 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Des Moines to Biloxi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Biloxi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Biloxi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Biloxi.

  • Can I find deals for business class flights from Des Moines to Biloxi?

    Yes. Cheapflights offers flight deals from Des Moines to Biloxi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Biloxi?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Biloxi (average of $126). Flying from Des Moines to Biloxi in June is currently the most expensive (average of $331). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 5 airlines flying from Des Moines to Biloxi

Discover the top 5 airlines that operate flights from Des Moines to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$129Average$197FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$236Average$394FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$367FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$258Average$409FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$278Average$406FlexibilityNo cancel feeOn-time63%

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