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Biloxi

$309+ Cheap flights from Des Moines (DSM) to Biloxi, MS

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MSY
Mar 15 — Mar 221
Sun 3/15
Sun 3/22
1 adult, Economy
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Cheap flight deals from Des Moines to Biloxi

Cheapest flights from Des Moines to Biloxi
Explore the most affordable flight options available from Des Moines to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.

This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/75:00 am
DSM
-
GPT
2 stops10h 59m
American Airlines
Wed 3/115:00 am
GPT
-
DSM
1 stop5h 34m
American Airlines
Deal found 2/10$309
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:20 pm
DSM
-
GPT
1 stop4h 55m
Delta
Wed 3/186:00 am
GPT
-
DSM
1 stop4h 48m
Delta
Deal found 2/11$364
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/298:00 am
DSM
-
GPT
1 stop5h 26m
United Airlines
Wed 9/25:15 pm
GPT
-
DSM
1 stop5h 15m
United Airlines
Deal found 2/9$409
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/85:00 am
DSM
-
GPT
1 stop5h 13m
American Airlines
Wed 3/115:00 am
GPT
-
DSM
1 stop5h 34m
American Airlines
Deal found 2/11$444
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/305:05 am
DSM
-
GPT
1 stop5h 08m
American Airlines
Fri 4/34:29 pm
GPT
-
DSM
1 stop5h 30m
American Airlines
Deal found 2/12$445
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/85:20 pm
DSM
-
GPT
1 stop4h 55m
Delta
Wed 3/116:00 am
GPT
-
DSM
2 stops10h 54m
Delta
Deal found 2/11$454

Find flight deals from Des Moines to Biloxi

Keep the following information in mind while searching for Des Moines to Biloxi flight deals. Data was last updated February 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$309
(American Airlines)

Popular in

November

Cheapest in

August

Average price

$353
Provider with most accurate pricing for Des Moines-Gulfport Biloxi Regional flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Gulfport Biloxi Regional flights.
Search Deals
From Des Moines to Biloxi
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($20 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Des Moines to Biloxi that are best for you.

Fly from

Des Moines

Fly to

Biloxi

Route

Depart

Return

Price

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sat 3/7

5:00 am-3:59 pm

2 stops10h 59m

Gulfport Biloxi Regional

Wed 3/11

5:00 am-10:34 am

1 stop5h 34m

$309

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Wed 3/11

5:20 pm-10:15 pm

1 stop4h 55m

Gulfport Biloxi Regional

Wed 3/18

6:00 am-10:48 am

1 stop4h 48m

$364

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sun 3/8

5:00 am-10:13 am

1 stop5h 13m

Gulfport Biloxi Regional

Wed 3/11

5:00 am-10:34 am

1 stop5h 34m

$444

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Mon 3/30

5:05 am-10:13 am

1 stop5h 08m

Gulfport Biloxi Regional

Fri 4/3

4:29 pm-9:59 pm

1 stop5h 30m

$445

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sun 3/8

5:20 pm-10:15 pm

1 stop4h 55m

Gulfport Biloxi Regional

Wed 3/11

6:00 am-4:54 pm

2 stops10h 54m

$454

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Thu 7/9

5:30 am-10:55 am

1 stop5h 25m

Gulfport Biloxi Regional

Wed 7/15

11:25 am-6:25 pm

1 stop7h 00m

$459

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sun 5/10

7:45 am-7:41 am

2 stops23h 56m

Gulfport Biloxi Regional

Sun 5/17

7:50 pm-9:33 am

1 stop13h 43m

$466

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Fri 4/10

6:20 am-4:13 pm

2 stops9h 53m

$315

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Tue 2/24

5:15 pm-9:54 pm

1 stop4h 39m

$352

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Tue 2/24

11:30 am-7:34 pm

2 stops8h 04m

$357

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/10

Showing 1-10 of 12 results
1
2

Best time to book a flight from Des Moines to Biloxi

Have a flexible travel schedule? Discover the best time to fly to Biloxi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Biloxi

What is the cheapest month to book a flight from Des Moines to Biloxi?

Currently, November is the cheapest month in which you can book a flight from Des Moines to Biloxi (average of $100). Flying from Des Moines to Biloxi in May is currently the most expensive (average of $271). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to B1L?

Find hourly flight availability from Des Moines to Biloxi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 13, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Biloxi as you normally would.

Reviews of airlines servicing Biloxi

Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated February 13, 2026.
Read reviews from past customers who have flown American Airlines from Des Moines to Biloxi. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,275 reviews

Crew

8.0

Entertainment

6.9

Comfort

7.2

Overall

7.2

Boarding

7.5

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,275 reviews
American Airlines
7.2
Good
11,275 reviews

Crew

8.0

Entertainment

6.9

Comfort

7.2

Overall

7.2

Boarding

7.5

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Biloxi?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Biloxi from Des Moines. Booking flights from Des Moines (DSM) to Biloxi should be relatively easy as there are 0 daily outbound flights to Biloxi from 5 different airlines.

  • How long is the flight from Des Moines to Biloxi?

    American Airlines and Delta can get you from Des Moines to Biloxi in just under 4h 55m. Your travel time can differ by up to 6h 04m. Des Moines and Biloxi are separated by a distance of 810 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Des Moines to Biloxi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Biloxi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Biloxi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Biloxi.

  • Can I find deals for business class flights from Des Moines to Biloxi?

    Yes. Cheapflights offers flight deals from Des Moines to Biloxi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Biloxi?

    Currently, November is the cheapest month in which you can book a flight from Des Moines to Biloxi (average of $100). Flying from Des Moines to Biloxi in May is currently the most expensive (average of $271). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 5 airlines flying from Des Moines to Biloxi

Discover the top 5 airlines that operate flights from Des Moines to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$121Average$214FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$236Average$395FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$350FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$244Average$334FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$270Average$385FlexibilityNo cancel feeOn-time63%

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