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Biloxi

$249+ Cheap flights from Des Moines (DSM) to Biloxi, MS

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MSY
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheap flight deals from Des Moines to Biloxi

Keep the following information in mind while searching for Des Moines to Biloxi flight deals. Data was last updated July 29, 2025.

Round-trip from

$249
(Delta)

Popular in

February

Cheapest in

January

Average price

$403
From Des Moines to Biloxi
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($10 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
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Find flight deals from Des Moines to Biloxi

Cheapest flights from Des Moines to Biloxi
Explore the most affordable flight options available from Des Moines to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/135:12 pmDSM - GPT
1 stop4h 27mDelta
Fri 9/196:08 amGPT - DSM
1 stop7h 12mDelta
Deal found 7/28$249
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/135:10 amDSM - GPT
2 stops11h 50mAmerican Airlines
Thu 9/1812:52 pmGPT - DSM
2 stops9h 02mAmerican Airlines
Deal found 7/28$259
This Mytrip deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/248:30 amDSM - GPT
3 stops23h 15mMultiple Airlines
Sun 8/3112:55 pmGPT - DSM
2 stops23h 06mMultiple Airlines
Deal found 7/27$634

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Des Moines to Biloxi that are best for you.

Fly from

Des Moines

Fly to

Biloxi

Route

Depart

Return

Price

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sat 9/13

5:12 pm-9:39 pm

1 stop4h 27m

Gulfport Biloxi Regional

Fri 9/19

6:08 am-1:20 pm

1 stop7h 12m

$249

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sat 9/13

5:10 am-5:00 pm

2 stops11h 50m

Gulfport Biloxi Regional

Thu 9/18

12:52 pm-9:54 pm

2 stops9h 02m

$259

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sun 8/24

8:30 am-7:45 am

3 stops23h 15m

Gulfport Biloxi Regional

Sun 8/31

12:55 pm-12:01 pm

2 stops23h 06m

$634

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from Des Moines to Biloxi

Have a flexible travel schedule? Discover the best time to fly to Biloxi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Biloxi

What is the cheapest month to book a flight from Des Moines to Biloxi?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Biloxi (average of $256). Flying from Des Moines to Biloxi in April is currently the most expensive (average of $343). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to B1L?

Find hourly flight availability from Des Moines to Biloxi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Biloxi as you normally would.

How much does it cost to fly round-trip from Des Moines to Biloxi?

Reviews of airlines servicing Biloxi

Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated July 29, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Des Moines to Biloxi. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,977 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,977 reviews
Delta
8.0
Very good
7,977 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,977 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Biloxi?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Biloxi from Des Moines. Booking flights from Des Moines (DSM) to Biloxi should be relatively easy as there are 0 daily outbound flights to Biloxi from 5 different airlines.

  • Can I find deals for flights from Des Moines to Biloxi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Biloxi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Biloxi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Biloxi.

  • Can I find deals for business class flights from Des Moines to Biloxi?

    Yes. Cheapflights offers flight deals from Des Moines to Biloxi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Biloxi?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Biloxi (average of $256). Flying from Des Moines to Biloxi in April is currently the most expensive (average of $343). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 5 airlines flying from Des Moines to Biloxi

Discover the top 5 airlines that operate flights from Des Moines to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$139Average$181FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$193Average$395FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$374FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$259Average$430FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$306Average$405FlexibilityNo cancel feeOn-time63%

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