$153+ Cheap flights from Mississippi to St. Louis (STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/22. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — STL
Nov 2 — Nov 91
Round-trip
1 adult, Economy
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Find cheap flights from Mississippi to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mississippi to St. Louis
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Cheapest flights from Mississippi to St. LouisExplore the most affordable flight options available from Mississippi to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 3, 2026.
Explore the most affordable flight options available from Mississippi to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 3, 2026.
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:50 pm -
1 stop5h 52m
Thu 11/127:18 pm -
1 stop3h 47m
Deal found 9/30![Delta logo]()
$279
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:50 pm -
1 stop4h 23m
Tue 12/157:03 am -
1 stop6h 08m
Deal found 9/29![Delta logo]()
$291
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/184:55 pm -
1 stop5h 31m
Tue 12/159:40 am -
2 stops9h 54m
Deal found 9/29![United Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2412:30 pm -
1 stop4h 15m
Mon 10/262:20 pm -
1 stop7h 35m
Deal found 10/1![Southwest logo]()
$353
This United Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:14 pm -
1 stop5h 16m
Wed 10/218:35 am -
1 stop7h 37m
Deal found 10/2![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:00 pm -
2 stops10h 59m
Sun 10/186:15 am -
1 stop7h 10m
Deal found 9/28![United Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:14 pm -
1 stop5h 16m
Thu 10/811:10 am -
1 stop5h 02m
Deal found 9/30![United Airlines logo]()
$403
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:22 pm -
1 stop5h 21m
Mon 10/55:40 am -
1 stop5h 33m
Deal found 9/29![American Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:49 pm -
2 stops11h 30m
Wed 10/216:32 am -
1 stop4h 41m
Deal found 10/2![American Airlines logo]()
$420
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/222:56 pm -
1 stop7h 34m
Mon 10/268:30 am -
1 stop5h 38m
Deal found 9/28![United Airlines logo]()
$436
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:08 am -
2 stops12h 33m
Mon 10/56:15 am -
1 stop7h 10m
Deal found 9/29![United Airlines logo]()
$443
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/282:02 pm -
1 stop6h 21m
Fri 1/16:15 am -
1 stop7h 12m
Deal found 9/29![United Airlines logo]()
$447
Best flights from Mississippi to St. LouisDiscover carefully curated flight deals from Mississippi to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 3, 2026.
Discover carefully curated flight deals from Mississippi to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 3, 2026.
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:50 pm -
1 stop5h 52m
Thu 11/127:18 pm -
1 stop3h 47m
Deal found 9/30![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2412:30 pm -
1 stop4h 15m
Mon 10/265:10 am -
2 stops6h 15m
Deal found 10/1![Southwest logo]()
$364
This United Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:14 pm -
1 stop5h 16m
Wed 10/218:35 am -
1 stop7h 37m
Deal found 10/2![United Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:50 pm -
1 stop4h 23m
Tue 12/157:03 am -
1 stop6h 08m
Deal found 9/29![Delta logo]()
$291
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:08 am -
1 stop7h 02m
Sun 10/186:15 am -
1 stop7h 10m
Deal found 9/28![United Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/77:24 pm -
1 stop4h 41m
Sat 12/1212:36 pm -
1 stop3h 48m
Deal found 10/3![Delta logo]()
$357
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3012:00 pm -
1 stop4h 43m
Wed 2/36:15 am -
1 stop4h 58m
Deal found 9/28![United Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:05 pm -
1 stop5h 49m
Mon 10/195:35 pm -
1 stop4h 41m
Deal found 9/30![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/304:55 pm -
1 stop5h 35m
Wed 2/33:07 pm -
1 stop4h 26m
Deal found 10/2![United Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:40 am -
2 stops8h 15m
Thu 10/152:30 pm -
1 stop7h 25m
Deal found 9/29![Southwest logo]()
$494
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/2310:40 am -
1 stop6h 03m
Tue 1/268:50 am -
1 stop5h 28m
Deal found 9/28![United Airlines logo]()
$434
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/222:56 pm -
1 stop7h 34m
Mon 10/268:30 am -
1 stop5h 38m
Deal found 9/28![United Airlines logo]()
$436
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:33 pm -
1 stop4h 23m
Wed 10/215:35 pm -
1 stop5h 34m
Deal found 10/2![Delta logo]()
$489
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/282:02 pm -
1 stop6h 21m
Fri 1/16:15 am -
1 stop7h 12m
Deal found 9/29![United Airlines logo]()
$447
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:00 am -
1 stop7h 10m
Thu 10/156:15 am -
1 stop7h 18m
Deal found 9/29![United Airlines logo]()
$489
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/142:56 pm -
1 stop5h 20m
Sun 10/188:35 am -
1 stop5h 45m
Deal found 9/29![United Airlines logo]()
$595
Last-minute flights from Mississippi to St. LouisDiscover last-minute flight deals from Mississippi to St. Louis. Data last updated October 3, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to St. Louis. Data last updated October 3, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:14 pm -
1 stop5h 16m
Thu 10/811:10 am -
1 stop5h 02m
Deal found 9/30![United Airlines logo]()
$403
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:22 pm -
1 stop5h 21m
Mon 10/55:40 am -
1 stop5h 33m
Deal found 9/29![American Airlines logo]()
$409
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:08 am -
2 stops12h 33m
Mon 10/56:15 am -
1 stop7h 10m
Deal found 9/29![United Airlines logo]()
$443
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:00 pm -
2 stops10h 59m
Sun 10/186:15 am -
1 stop7h 10m
Deal found 9/28![United Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:14 pm -
1 stop5h 16m
Wed 10/218:35 am -
1 stop7h 37m
Deal found 10/2![United Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:49 pm -
2 stops11h 30m
Wed 10/216:32 am -
1 stop4h 41m
Deal found 10/2![American Airlines logo]()
$420
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/222:56 pm -
1 stop7h 34m
Mon 10/268:30 am -
1 stop5h 38m
Deal found 9/28![United Airlines logo]()
$436
This Southwest deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2412:30 pm -
1 stop4h 15m
Mon 10/262:20 pm -
1 stop7h 35m
Deal found 10/1![Southwest logo]()
$353
This American Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:27 pm -
1 stop5h 06m
Thu 11/55:00 am -
1 stop6h 11m
Deal found 10/2![American Airlines logo]()
$455
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:50 pm -
1 stop5h 52m
Thu 11/127:18 pm -
1 stop3h 47m
Deal found 9/30![Delta logo]()
$279
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:50 pm -
1 stop4h 23m
Tue 12/157:03 am -
1 stop6h 08m
Deal found 9/29![Delta logo]()
$291
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/184:55 pm -
1 stop5h 31m
Tue 12/159:40 am -
2 stops9h 54m
Deal found 9/29![United Airlines logo]()
$322
One-way flights from Mississippi to St. LouisSearch for one-way flight options from Mississippi to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 3, 2026.
Search for one-way flight options from Mississippi to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:45 pm -
2 stops21h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/2![Multiple Airlines logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/87:45 pm -
1 stop27h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Multiple Airlines logo]()
$162
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:42 pm -
1 stop5h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/1![American Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:08 am -
2 stops8h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/1![United Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:47 am -
1 stop6h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/1![American Airlines logo]()
$429
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2912:05 pm -
2 stops9h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Southwest logo]()
$551
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/297:29 pm -
1 stop4h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![American Airlines logo]()
$560
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/295:06 pm -
3 stops47h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$1,147
Find flight deals from Mississippi to St. Louis
Keep the following information in mind while searching for Mississippi to St. Louis flight deals. Data was last updated October 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $279 (Delta) |
One-way from | $153 (Kiwi.com) |
Popular in | March |
Cheapest in | February |
Average price | $496 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 3, 2026.
Use the filters below to find and compare flights from Mississippi to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GulfportSt. Louis
GPT Gulfport Biloxi Regional - STL Lambert-St Louis
GPTSTL
Gulfport Biloxi Regional
Thu 10/22
7:45 pm-5:40 pm
2 stops21h 55m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$153
GulfportSt. Louis
GPT Gulfport Biloxi Regional - STL Lambert-St Louis
GPTSTL
Gulfport Biloxi Regional
Sun 11/8
7:45 pm-11:16 pm
1 stop27h 31m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$162
JacksonSt. Louis
JAN Jackson-Evers Intl - STL Lambert-St Louis
JANSTL
Jackson-Evers Intl
Mon 11/9
3:50 pm-9:42 pm
1 stop5h 52m
Lambert-St Louis
Thu 11/12
7:18 pm-11:05 pm
1 stop3h 47m
$279
GulfportSt. Louis
GPT Gulfport Biloxi Regional - STL Lambert-St Louis
GPTSTL
Gulfport Biloxi Regional
Wed 11/18
1:50 pm-6:13 pm
1 stop4h 23m
Lambert-St Louis
Tue 12/15
7:03 am-1:11 pm
1 stop6h 08m
$291
JacksonSt. Louis
JAN Jackson-Evers Intl - STL Lambert-St Louis
JANSTL
Jackson-Evers Intl
Sat 10/10
12:15 pm-6:20 pm
1 stop6h 05m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$322
JacksonSt. Louis
JAN Jackson-Evers Intl - STL Lambert-St Louis
JANSTL
Jackson-Evers Intl
Sat 10/10
11:25 am-8:00 pm
2 stops8h 35m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$327
JacksonSt. Louis
JAN Jackson-Evers Intl - STL Lambert-St Louis
JANSTL
Jackson-Evers Intl
Mon 12/7
7:24 pm-12:05 am
1 stop4h 41m
Lambert-St Louis
Sat 12/12
12:36 pm-4:24 pm
1 stop3h 48m
$357
JacksonSt. Louis
JAN Jackson-Evers Intl - STL Lambert-St Louis
JANSTL
Jackson-Evers Intl
Sat 10/24
12:30 pm-4:45 pm
1 stop4h 15m
Lambert-St Louis
Mon 10/26
5:10 am-11:25 am
2 stops6h 15m
$364
GulfportSt. Louis
GPT Gulfport Biloxi Regional - STL Lambert-St Louis
GPTSTL
Gulfport Biloxi Regional
Wed 10/21
6:42 pm-11:59 pm
1 stop5h 17m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$369
GulfportSt. Louis
GPT Gulfport Biloxi Regional - STL Lambert-St Louis
GPTSTL
Gulfport Biloxi Regional
Sat 10/17
5:14 pm-10:30 pm
1 stop5h 16m
Lambert-St Louis
Wed 10/21
8:35 am-4:12 pm
1 stop7h 37m
$369
Showing 1-10 of 27 resultsSorted by cheapest first
Best time to book a flight from Mississippi to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Mississippi with our price prediction graph.
JAN-STL
GPT-STL
PIB-STL
HEZ-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to St. Louis
USMS-STL
JAN-STL
GPT-STL
PIB-STL
HEZ-STL
What is the cheapest month to book a flight from Mississippi to St. Louis?
Currently, March is the cheapest month in which you can book a flight from Mississippi to St. Louis (average of $291). Flying from Mississippi to St. Louis in December is currently the most expensive (average of $636). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Mississippi to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Wentzville
Chesterfield
Maryland Heights
Collinsville
Edwardsville
Glencoe
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Alternative routes for Mississippi to St. Louis
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Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mississippi to St. Louis by cabin class
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Mississippi and St. Louis flights
Browse other Mississippi and St. Louis flight options. Last updated on October 3, 2026.
Popular flight searches
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Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 3, 2026.
Mississippi to St. Louis flights
Consider these flights traveling from Mississippi to St. Louis.
Top 2 airlines flying from Mississippi to St. Louis
Discover the top 2 airlines that operate flights from Mississippi to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$264 | Average$368 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$266 | Average$434 | FlexibilityNo cancel fee | On-time71% |