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St. Louis

$108+ Cheap flights from Knoxville to St. Louis (TYS - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Knoxville to St. Louis

Cheapest flights from Knoxville to St. Louis
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:00 am
TYS
-
STL
1 stop6h 48m
American Airlines
Wed 4/295:20 am
STL
-
TYS
1 stop6h 10m
American Airlines
Deal found 1/28$233
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:55 pm
TYS
-
STL
1 stop7h 20m
Southwest
Mon 5/47:35 am
STL
-
TYS
1 stop3h 05m
Southwest
Deal found 1/27$234
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/74:55 pm
TYS
-
STL
1 stop7h 10m
Southwest
Wed 3/112:25 pm
STL
-
TYS
1 stop4h 40m
Southwest
Deal found 1/27$256
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/15:40 am
TYS
-
STL
1 stop6h 21m
American Airlines
Wed 3/44:13 pm
STL
-
TYS
1 stop7h 15m
American Airlines
Deal found 1/27$257
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/74:55 pm
TYS
-
STL
2 stops7h 20m
Southwest
Mon 3/92:35 pm
STL
-
TYS
1 stop5h 40m
Southwest
Deal found 1/27$262
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:10 am
TYS
-
STL
1 stop7h 23m
American Airlines
Sun 3/85:12 am
STL
-
TYS
1 stop5h 18m
American Airlines
Deal found 1/27$267
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:25 pm
TYS
-
STL
1 stop5h 40m
Southwest
Sun 3/86:35 am
STL
-
TYS
1 stop5h 20m
Southwest
Deal found 1/28$279
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/132:06 pm
TYS
-
STL
1 stop11h 21m
Multiple Airlines
Mon 2/168:22 pm
STL
-
TYS
2 stops36h 46m
Multiple Airlines
Deal found 1/26$283

Find flight deals from Knoxville to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$233
(American Airlines)

One-way from

$108
(Kiwi.com)

Popular in

November

Cheapest in

April

Average price

$294
Provider with most accurate pricing for Knoxville McGhee Tyson-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Lambert-St Louis flights.
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From Knoxville McGhee Tyson to Lambert-St Louis
Search Deals
One-way flight from Knoxville McGhee Tyson to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($74 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Fly from

Knoxville

Fly to

St. Louis

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 3/7

4:55 pm-11:05 pm

1 stop7h 10m

Lambert-St Louis

Wed 3/11

2:25 pm-8:05 pm

1 stop4h 40m

$256

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sun 3/1

5:40 am-11:01 am

1 stop6h 21m

Lambert-St Louis

Wed 3/4

4:13 pm-12:28 am

1 stop7h 15m

$257

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 3/7

4:55 pm-11:05 pm

1 stop7h 10m

Lambert-St Louis

Mon 3/9

2:35 pm-9:15 pm

1 stop5h 40m

$257

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 4/29

12:50 pm-7:20 pm

2 stops7h 30m

Lambert-St Louis

Mon 5/4

1:45 pm-8:20 pm

2 stops5h 35m

$274

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 3/6

7:25 pm-12:05 am

1 stop5h 40m

Lambert-St Louis

Sun 3/8

6:35 am-12:55 pm

1 stop5h 20m

$279

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 2/13

2:06 pm-12:27 am

1 stop11h 21m

Lambert-St Louis

Mon 2/16

8:22 pm-10:08 am

2 stops36h 46m

$283

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 3/5

7:25 pm-12:05 am

1 stop5h 40m

Lambert-St Louis

Sun 3/8

5:20 am-12:55 pm

2 stops6h 35m

$284

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 2/26

7:51 am-1:43 pm

1 stop6h 52m

Lambert-St Louis

Thu 3/5

5:12 am-11:31 am

1 stop5h 19m

$287

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 2/26

5:53 pm-6:51 am

2 stops37h 58m

Lambert-St Louis

Thu 3/5

3:49 pm-3:55 pm

1 stop23h 06m

$288

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Mon 2/23

7:22 pm-6:51 am

2 stops36h 29m

$108

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 19 results
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Compare providers for flights from Knoxville to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to St. Louis in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to St. Louis

What is the cheapest month to book a flight from Knoxville to St. Louis?

Currently, January is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $152). Flying from Knoxville to St. Louis in November is currently the most expensive (average of $240). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to St. Louis?

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated January 29, 2026.
Read through reviews of airlines operating flights from Knoxville to St. Louis, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Boarding

8.1

Food

7.2

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Boarding

8.1

Food

7.2

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,205 reviews
Delta
7.9
Good
8,128 reviews

Boarding

8.1

Food

7.2

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to St. Louis?

    Airlines like Southwest and American Airlines fly from Knoxville to St. Louis in about 6h 21m. The time it takes to get you to your destination can typically vary by up to 49m. Knoxville and St. Louis are separated by a distance of 405 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to St. Louis round-trip?

    Cheapflights users have booked flights from Knoxville to St. Louis round-trip from $198. Another airline that can offer you cheap pricing is Delta. These flights start at 44% lower than the current average price 3 months from now.

  • Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?

    Yes. In addition to deals on Knoxville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to St. Louis.

  • Can I find deals for business class flights from Knoxville to St. Louis?

    Yes. Cheapflights offers flight deals from Knoxville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to St. Louis?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $152). Flying from Knoxville to St. Louis in November is currently the most expensive (average of $240). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Knoxville to St. Louis

Discover the top 2 airlines that operate flights from Knoxville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$343FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$302FlexibilityNo cancel feeOn-timeN/A

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