How long is the flight from Knoxville to St. Louis?

Airlines like American Airlines, Delta, and Southwest fly from Knoxville to St. Louis in about 4h 13m. The time it takes to get you to your destination can typically vary by up to 2h 14m. Knoxville and St. Louis are separated by a distance of 405 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines flying from Knoxville to St. Louis round-trip?

Cheapflights users have booked flights from Knoxville to St. Louis round-trip from $198. Another airline that can offer you cheap pricing is Delta. These flights start at 43% lower than the current average price 3 months from now.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Most accurate provider : When it comes to deals on Knoxville-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-St. Louis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Knoxville-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?

Yes. In addition to deals on Knoxville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to St. Louis.

Can I find deals for business class flights from Knoxville to St. Louis?

Yes. Cheapflights offers flight deals from Knoxville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$138+ Flights from Knoxville to St. Louis

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Cheap flight deals from Knoxville to St. Louis

Cheapest flights from Knoxville to St. Louis
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 12, 2025.

jue. 12/184:26 pmTYS - STL

2 stops16h 46mMultiple Airlines

lun. 12/2210:40 amSTL - TYS

1 stop10h 13mMultiple Airlines

Deal found 12/11

$446

vie. 12/262:00 pmTYS - STL

1 stop6h 22mUnited Airlines

mar. 12/305:02 pmSTL - TYS

1 stop4h 37mUnited Airlines

Deal found 12/11

$478

vie. 12/195:35 pmTYS - STL

1 stop5h 08mUnited Airlines

dom. 12/213:10 pmSTL - TYS

1 stop6h 29mUnited Airlines

Deal found 12/9

$507

jue. 12/115:40 amTYS - STL

1 stop6h 05mDelta

lun. 12/1511:40 amSTL - TYS

1 stop4h 13mDelta

Deal found 12/10

$547

vie. 12/198:00 amTYS - STL

1 stop14h 25mMultiple Airlines

dom. 12/2110:57 amSTL - TYS

2 stops9h 59mMultiple Airlines

Deal found 12/9

$567

lun. 12/151:52 pmTYS - STL

1 stop4h 11mUnited Airlines

mar. 12/1611:25 amSTL - TYS

1 stop4h 46mUnited Airlines

Deal found 12/10

$607

lun. 12/151:05 pmTYS - STL

1 stop10h 28mMultiple Airlines

mar. 12/163:30 pmSTL - TYS

2 stops21h 33mMultiple Airlines

Deal found 12/10

$679

jue. 12/117:25 pmTYS - STL

2 stops21h 15mUnited Airlines

lun. 12/158:30 amSTL - TYS

1 stop5h 13mUnited Airlines

Deal found 12/10

$854

Best flights from Knoxville to St. Louis
Discover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated diciembre 12, 2025.

jue. 2/51:39 pmTYS - STL

2 stops18h 12mMultiple Airlines

vie. 2/611:18 amSTL - TYS

1 stop10h 10mMultiple Airlines

Deal found 12/10

$244

jue. 1/15:23 amTYS - STL

1 stop6h 27mAmerican Airlines

lun. 1/123:54 pmSTL - TYS

1 stop4h 27mAmerican Airlines

Deal found 12/11

$269

jue. 2/55:40 amTYS - STL

1 stop4h 13mDelta

vie. 2/66:00 amSTL - TYS

1 stop4h 08mDelta

Deal found 12/10

$279

vie. 3/67:25 pmTYS - STL

1 stop5h 40mSouthwest

sáb. 3/79:30 amSTL - TYS

1 stop8h 05mSouthwest

Deal found 12/10

$279

dom. 1/186:45 amTYS - STL

1 stop6h 44mUnited Airlines

jue. 1/2210:07 amSTL - TYS

1 stop8h 43mUnited Airlines

Deal found 12/10

$299

vie. 1/1612:19 pmTYS - STL

1 stop8h 10mAmerican Airlines

lun. 1/193:37 pmSTL - TYS

1 stop6h 10mAmerican Airlines

Deal found 12/11

$279

vie. 1/26:30 amTYS - STL

1 stop17h 03mMultiple Airlines

lun. 1/128:50 amSTL - TYS

1 stop12h 38mMultiple Airlines

Deal found 12/10

$304

vie. 1/95:40 amTYS - STL

1 stop6h 22mDelta

lun. 1/126:55 pmSTL - TYS

1 stop3h 50mDelta

Deal found 12/11

$313

sáb. 1/32:23 pmTYS - STL

2 stops20h 17mMultiple Airlines

lun. 1/128:50 amSTL - TYS

1 stop7h 38mMultiple Airlines

Deal found 12/11

$317

vie. 1/912:15 pmTYS - STL

2 stops6h 59mAmerican Airlines

lun. 1/126:00 amSTL - TYS

1 stop7h 32mAmerican Airlines

Deal found 12/11

$318

Last-minute flights from Knoxville to St. Louis
Discover last-minute flight deals from Knoxville to St. Louis. Data last updated diciembre 12, 2025 and is based on user searches.

jue. 1/15:23 amTYS - STL

1 stop6h 27mAmerican Airlines

lun. 1/123:54 pmSTL - TYS

1 stop4h 27mAmerican Airlines

Deal found 12/11

$269

vie. 1/26:30 amTYS - STL

1 stop17h 03mMultiple Airlines

lun. 1/128:50 amSTL - TYS

1 stop12h 38mMultiple Airlines

Deal found 12/10

$304

vie. 1/26:30 amTYS - STL

1 stop17h 03mMultiple Airlines

vie. 1/95:11 pmSTL - TYS

1 stop17h 29mMultiple Airlines

Deal found 12/10

$338

sáb. 1/32:23 pmTYS - STL

2 stops20h 17mMultiple Airlines

lun. 1/128:50 amSTL - TYS

1 stop7h 38mMultiple Airlines

Deal found 12/11

$317

mar. 1/65:40 amTYS - STL

1 stop4h 13mDelta

dom. 1/116:55 pmSTL - TYS

1 stop3h 50mDelta

Deal found 12/10

$265

mar. 1/64:00 pmTYS - STL

2 stops6h 51mAmerican Airlines

dom. 1/113:37 pmSTL - TYS

1 stop6h 10mAmerican Airlines

Deal found 12/10

$270

vie. 1/95:40 amTYS - STL

1 stop6h 22mDelta

lun. 1/126:55 pmSTL - TYS

1 stop3h 50mDelta

Deal found 12/11

$313

vie. 1/912:15 pmTYS - STL

2 stops6h 59mAmerican Airlines

lun. 1/126:00 amSTL - TYS

1 stop7h 32mAmerican Airlines

Deal found 12/11

$318

vie. 1/1612:19 pmTYS - STL

1 stop8h 10mAmerican Airlines

lun. 1/193:37 pmSTL - TYS

1 stop6h 10mAmerican Airlines

Deal found 12/11

$279

vie. 1/167:15 amTYS - STL

2 stops24h 36mMultiple Airlines

lun. 1/198:39 amSTL - TYS

1 stop7h 49mMultiple Airlines

Deal found 12/11

$332

dom. 1/186:45 amTYS - STL

1 stop5h 17mUnited Airlines

jue. 1/228:05 amSTL - TYS

1 stop4h 19mUnited Airlines

Deal found 12/9

$299

One-way flights from Knoxville to St. Louis
Search for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated diciembre 12, 2025.

lun. 2/169:36 pmTYS - STL

2 stops34h 15mMultiple Airlines

Deal found 12/11

$138

lun. 2/166:38 pmTYS - STL

1 stop5h 45mAmerican Airlines

Deal found 12/11

$220

mar. 12/236:45 amTYS - STL

1 stop6h 42mUnited Airlines

Deal found 12/11

$459

Find flight deals from Knoxville to St. Louis

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$244 (Kiwi.com)
One-way from	$138 (Kiwi.com)
Popular in	November
Cheapest in	July
Average price	$389

Provider with most accurate pricing for Knoxville McGhee Tyson-Lambert-St Louis flight deals.

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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Lambert-St Louis flights.

Search Deals

From Knoxville McGhee Tyson to Lambert-St Louis

Search Deals

One-way flight from Knoxville McGhee Tyson to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 18% potential increase in price ($82 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($18 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

jue. 2/5

1:39 pm-6:51 am

2 stops18h 12m

Lambert-St Louis

vie. 2/6

11:18 am-10:28 pm

1 stop10h 10m

$244

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

jue. 1/1

5:23 am-10:50 am

1 stop6h 27m

Lambert-St Louis

lun. 1/12

3:54 pm-9:21 pm

1 stop4h 27m

$269

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

jue. 2/5

5:40 am-8:53 am

1 stop4h 13m

Lambert-St Louis

vie. 2/6

6:00 am-11:08 am

1 stop4h 08m

$279

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

vie. 3/6

7:25 pm-12:05 am

1 stop5h 40m

Lambert-St Louis

sáb. 3/7

9:30 am-6:35 pm

1 stop8h 05m

$279

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

vie. 1/16

12:19 pm-7:29 pm

1 stop8h 10m

Lambert-St Louis

lun. 1/19

3:37 pm-10:47 pm

1 stop6h 10m

$279

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

dom. 1/18

6:45 am-12:29 pm

1 stop6h 44m

Lambert-St Louis

jue. 1/22

10:07 am-7:50 pm

1 stop8h 43m

$299

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

vie. 1/2

6:30 am-10:33 pm

1 stop17h 03m

Lambert-St Louis

lun. 1/12

8:50 am-10:28 pm

1 stop12h 38m

$304

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

vie. 1/9

5:40 am-11:02 am

1 stop6h 22m

Lambert-St Louis

lun. 1/12

6:55 pm-11:45 pm

1 stop3h 50m

$313

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

sáb. 1/3

2:23 pm-9:40 am

2 stops20h 17m

Lambert-St Louis

lun. 1/12

8:50 am-5:28 pm

1 stop7h 38m

$317

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

vie. 1/9

12:15 pm-6:14 pm

2 stops6h 59m

Lambert-St Louis

lun. 1/12

6:00 am-2:32 pm

1 stop7h 32m

$318

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 13 results

Compare providers for flights from Knoxville to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to St. Louis in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Knoxville-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-St. Louis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Knoxville-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to St. Louis

What is the cheapest month to book a flight from Knoxville to St. Louis?

Currently, April is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $198). Flying from Knoxville to St. Louis in November is currently the most expensive (average of $240). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to STL?

A simple way to save on the total cost of your ticket is to fly from Knoxville to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 7% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing St. Louis

Read through reviews of airlines operating flights from Knoxville to St. Louis, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Delta

7.9

Good

8,008 reviews

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

American Airlines

7.2

Good

11,050 reviews

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

Related info for your journey

How long is the flight from Knoxville to St. Louis?
Airlines like American Airlines, Delta, and Southwest fly from Knoxville to St. Louis in about 4h 13m. The time it takes to get you to your destination can typically vary by up to 2h 14m. Knoxville and St. Louis are separated by a distance of 405 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines flying from Knoxville to St. Louis round-trip?
Cheapflights users have booked flights from Knoxville to St. Louis round-trip from $198. Another airline that can offer you cheap pricing is Delta. These flights start at 43% lower than the current average price 3 months from now.
Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?
Yes. In addition to deals on Knoxville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to St. Louis.
Can I find deals for business class flights from Knoxville to St. Louis?
Yes. Cheapflights offers flight deals from Knoxville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Knoxville to St. Louis?
Currently, April is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $198). Flying from Knoxville to St. Louis in November is currently the most expensive (average of $240). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Other flights to St. Louis

Top 2 airlines flying from Knoxville to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$198	Average$342	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$228	Average$302	FlexibilityNo cancel fee	On-timeN/A

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$138+ Cheap flights from Knoxville to St. Louis (TYS - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/16. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Knoxville to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Knoxville to St. Louis

Cheapest flights from Knoxville to St. LouisExplore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 12, 2025.

Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 12, 2025.

Find flight deals from Knoxville to St. Louis

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Compare providers for flights from Knoxville to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to St. Louis in December.

Best time to book a flight from Knoxville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to St. Louis

What is the cheapest month to book a flight from Knoxville to St. Louis?

What is the cheapest time of day to fly from TYS to STL?

Reviews of airlines servicing St. Louis

Read through reviews of airlines operating flights from Knoxville to St. Louis, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Knoxville to St. Louis?

What are the cheapest airlines flying from Knoxville to St. Louis round-trip?

Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?

How can I find direct flights from Knoxville to St. Louis?

Can I find deals for business class flights from Knoxville to St. Louis?

What is the cheapest month to book a flight from Knoxville to St. Louis?

Traveling to a place near St. Louis?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Knoxville to St. Louis

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Cheapest flights from Knoxville to St. Louis
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 12, 2025.