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$88+ Cheap flights from Knoxville to St. Louis (TYS - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Aug 25 — Sep 11
Mon 8/25
Mon 9/1
1 adult, Economy
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Cheap flight deals from Knoxville to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 20, 2025.

Round-trip from

$211
(FlightHub)

One-way from

$88
(FlightHub)

Popular in

March

Cheapest in

December

Average price

$347
From Knoxville McGhee Tyson to Lambert-St Louis
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One-way flight from Knoxville McGhee Tyson to Lambert-St Louis
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Highest demand for flights based on searches. 12% potential increase in price ($46 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Knoxville to St. Louis

Cheapest flights from Knoxville to St. Louis
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.

This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/258:40 pmTYS - STL
1 stop13h 26mFrontier
Sun 9/287:55 pmSTL - TYS
1 stop22h 50mFrontier
Deal found 8/18$211
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/306:39 pmTYS - STL
1 stop5h 35mAmerican Airlines
Tue 9/25:30 pmSTL - TYS
1 stop5h 49mAmerican Airlines
Deal found 8/19$219
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/174:31 pmTYS - STL
1 stop18h 09mMultiple Airlines
Wed 9/247:55 pmSTL - TYS
1 stop16h 48mMultiple Airlines
Deal found 8/20$225
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:08 pmTYS - STL
1 stop6h 16mDelta
Mon 9/296:42 pmSTL - TYS
1 stop4h 02mDelta
Deal found 8/19$229
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/56:14 pmTYS - STL
1 stop4h 48mDelta
Mon 9/85:11 pmSTL - TYS
1 stop5h 37mDelta
Deal found 8/18$234
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/26:14 pmTYS - STL
1 stop4h 48mDelta
Sat 9/65:11 pmSTL - TYS
1 stop5h 37mDelta
Deal found 8/18$239
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/145:44 amTYS - STL
1 stop5h 42mDelta
Wed 10/155:15 pmSTL - TYS
1 stop4h 52mDelta
Deal found 8/18$251
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2811:54 amTYS - STL
1 stop3h 43mDelta
Sun 8/316:00 amSTL - TYS
1 stop6h 08mDelta
Deal found 8/18$253
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/157:45 amTYS - STL
1 stop6h 37mDelta
Sun 10/196:00 amSTL - TYS
1 stop3h 36mDelta
Deal found 8/18$254
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/155:00 amTYS - STL
1 stop5h 38mAmerican Airlines
Sun 10/197:16 amSTL - TYS
1 stop6h 17mAmerican Airlines
Deal found 8/20$259
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/289:35 amTYS - STL
1 stop7h 07mAmerican Airlines
Sun 8/319:23 amSTL - TYS
1 stop7h 26mAmerican Airlines
Deal found 8/18$269

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Fly from

Knoxville

Fly to

St. Louis

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 9/25

8:40 pm-9:06 am

1 stop13h 26m

Lambert-St Louis

Sun 9/28

7:55 pm-7:45 pm

1 stop22h 50m

$211

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 8/30

6:39 pm-11:14 pm

1 stop5h 35m

Lambert-St Louis

Tue 9/2

5:30 pm-12:19 am

1 stop5h 49m

$219

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 9/17

4:31 pm-9:40 am

1 stop18h 09m

Lambert-St Louis

Wed 9/24

7:55 pm-1:43 pm

1 stop16h 48m

$225

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 9/26

6:08 pm-11:24 pm

1 stop6h 16m

Lambert-St Louis

Mon 9/29

6:42 pm-11:44 pm

1 stop4h 02m

$229

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 9/25

6:08 pm-11:24 pm

1 stop6h 16m

Lambert-St Louis

Sat 9/27

6:01 am-10:25 am

1 stop3h 24m

$229

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 9/18

7:18 am-12:23 pm

1 stop6h 05m

Lambert-St Louis

Sat 9/20

8:50 am-3:41 pm

1 stop5h 51m

$229

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 10/2

5:45 am-9:59 am

1 stop5h 14m

Lambert-St Louis

Tue 10/7

9:10 am-1:42 pm

1 stop3h 32m

$229

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 9/26

7:45 pm-11:07 pm

1 stop4h 22m

Lambert-St Louis

Mon 9/29

9:56 am-4:19 pm

1 stop5h 23m

$229

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 10/2

6:00 am-10:21 am

1 stop5h 21m

Lambert-St Louis

Mon 10/6

6:06 am-12:56 pm

1 stop5h 50m

$229

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 9/26

6:08 pm-11:24 pm

1 stop6h 16m

Lambert-St Louis

Tue 9/30

6:40 am-11:41 am

1 stop4h 01m

$229

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/18

Showing 1-10 of 21 results
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Best time to book a flight from Knoxville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to St. Louis

What is the cheapest month to book a flight from Knoxville to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $311). Flying from Knoxville to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to STL?

Find hourly flight availability from Knoxville to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 20, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 8% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated August 20, 2025.
Read through reviews of airlines operating flights from Knoxville to St. Louis, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,928 reviews
Delta
8.0
Very good
7,982 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,982 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to St. Louis?

    Airlines like Frontier, American Airlines, and Delta fly from Knoxville to St. Louis in about 5h 35m. The time it takes to get you to your destination can typically vary by up to 7h 51m. Knoxville and St. Louis are separated by a distance of 405 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to St. Louis round-trip?

    Cheapflights users have booked flights from Knoxville to St. Louis round-trip from $198. Other airlines that can offer you cheap pricing are Delta, from $228, and United Airlines, from $258. These flights start at 39% lower than the current average price 3 months from now.

  • Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?

    Yes. In addition to deals on Knoxville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to St. Louis.

  • Can I find deals for business class flights from Knoxville to St. Louis?

    Yes. Cheapflights offers flight deals from Knoxville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $311). Flying from Knoxville to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
St. Peters
Glencoe
Alton
Chesterfield
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Knoxville to St. Louis

Discover the top 3 airlines that operate flights from Knoxville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$322FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$302FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$258Average$293FlexibilityNo cancel feeOn-time69%

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