HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
St. Louis

$117+ Cheap flights from Knoxville to St. Louis (TYS - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/8. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to St. Louis with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$214
(Delta)

One-way from

$117
(Mytrip)

Popular in

March

Cheapest in

July

Average price

$319
Provider with most accurate pricing for Knoxville McGhee Tyson-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Lambert-St Louis flights.
Search Deals
From Knoxville McGhee Tyson to Lambert-St Louis
Search Deals
One-way flight from Knoxville McGhee Tyson to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($62 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2025
Search Deals

Find flight deals from Knoxville to St. Louis

Cheapest flights from Knoxville to St. Louis
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/308:25 amTYS - STL
1 stop4h 39mDelta
Mon 6/23:40 pmSTL - TYS
1 stop3h 14mDelta
Deal found 4/29$214
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2312:02 pmTYS - STL
1 stop8h 45mAmerican Airlines
Sun 5/257:00 amSTL - TYS
1 stop6h 05mAmerican Airlines
Deal found 4/29$229
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/147:00 amTYS - STL
1 stop4h 45mUnited Airlines
Sat 6/145:27 pmSTL - TYS
1 stop4h 38mUnited Airlines
Deal found 4/29$275
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/34:25 pmTYS - STL
2 stops25h 39mMultiple Airlines
Sun 7/65:15 pmSTL - TYS
2 stops23h 05mMultiple Airlines
Deal found 4/30$328

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Fly from

Knoxville

Fly to

St. Louis

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 5/30

8:25 am-12:04 pm

1 stop4h 39m

Lambert-St Louis

Mon 6/2

3:40 pm-7:54 pm

1 stop3h 14m

$214

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 5/23

12:02 pm-7:47 pm

1 stop8h 45m

Lambert-St Louis

Sun 5/25

7:00 am-2:05 pm

1 stop6h 05m

$229

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 6/14

7:00 am-10:45 am

1 stop4h 45m

Lambert-St Louis

Sat 6/14

5:27 pm-11:05 pm

1 stop4h 38m

$275

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 7/3

4:25 pm-5:04 pm

2 stops25h 39m

Lambert-St Louis

Sun 7/6

5:15 pm-5:20 pm

2 stops23h 05m

$328

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sun 6/8

5:25 pm-9:12 am

1 stop16h 47m

$117

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 9/6

4:00 pm-8:47 pm

1 stop5h 47m

$126

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sun 6/8

7:43 pm-6:41 pm

3 stops23h 58m

$232

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 9/6

5:35 pm-10:02 am

2 stops17h 27m

$280

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Compare providers for flights from Knoxville to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to St. Louis in May.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to St. Louis

What is the cheapest month to book a flight from Knoxville to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $311). Flying from Knoxville to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to STL?

Find hourly flight availability from Knoxville to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 8% on your trip compared to booking a flight in the morning.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated May 1, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines and American Airlines from Knoxville to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
6.0
Okay
3,287 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to St. Louis round-trip?

    Cheapflights users have booked flights from Knoxville to St. Louis round-trip from $214. Other airlines that can offer you cheap pricing are American Airlines, from $229, and United Airlines, from $275. These flights start at 31% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Knoxville to St. Louis one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $117. Users have also found prices from $126 and $280 on Delta and United Airlines, respectively.

  • Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?

    Yes. In addition to deals on Knoxville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to St. Louis.

  • Can I find deals for business class flights from Knoxville to St. Louis?

    Yes. Cheapflights offers flight deals from Knoxville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $311). Flying from Knoxville to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Fenton
Maryland Heights
Fairview Heights
Collinsville
Wentzville
Eureka
St. Peters
Festus
Glencoe
Alton
Farmington
O'Fallon

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Knoxville to St. Louis

Discover the top 3 airlines that operate flights from Knoxville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$284FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$213Average$288FlexibilityNo cancel feeOn-time69%
DeltaCheapest$228Average$301FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.