$117+ Cheap flights from Knoxville to St. Louis (TYS - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/29. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Apr 8 — Apr 151
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to St. Louis
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Cheapest flights from Knoxville to St. LouisExplore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 9, 2026.
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 9, 2026.
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:20 pm
TYS
- STL
1 stop5h 20m
Southwest
Sat 3/2812:40 pm
STL
- TYS
1 stop8h 30m
Southwest
Deal found 3/4![Southwest logo]()
$250
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/23:55 pm
TYS
- STL
1 stop5h 25m
Southwest
Mon 5/45:45 am
STL
- TYS
1 stop7h 25m
Southwest
Deal found 3/4![Southwest logo]()
$254
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:48 pm
TYS
- STL
1 stop4h 08m
American Airlines
Tue 5/128:55 am
STL
- TYS
1 stop6h 45m
American Airlines
Deal found 3/6![American Airlines logo]()
$257
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/267:25 pm
TYS
- STL
1 stop5h 40m
Southwest
Sat 3/2812:40 pm
STL
- TYS
1 stop8h 30m
Southwest
Deal found 3/4![Southwest logo]()
$262
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:30 am
TYS
- STL
2 stops7h 00m
Southwest
Thu 4/910:50 am
STL
- TYS
2 stops8h 30m
Southwest
Deal found 3/5![Southwest logo]()
$267
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:05 am
TYS
- STL
1 stop6h 45m
Southwest
Mon 5/47:35 am
STL
- TYS
1 stop3h 05m
Southwest
Deal found 3/4![Southwest logo]()
$268
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:05 am
TYS
- STL
2 stops8h 20m
Southwest
Sun 4/197:35 am
STL
- TYS
1 stop3h 05m
Southwest
Deal found 3/6![Southwest logo]()
$273
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:48 pm
TYS
- STL
1 stop4h 08m
American Airlines
Mon 5/115:20 am
STL
- TYS
1 stop6h 10m
American Airlines
Deal found 3/4![American Airlines logo]()
$277
Best flights from Knoxville to St. LouisDiscover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 9, 2026.
Discover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 9, 2026.
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:20 pm
TYS
- STL
1 stop5h 20m
Southwest
Sat 3/2812:40 pm
STL
- TYS
1 stop8h 30m
Southwest
Deal found 3/4![Southwest logo]()
$250
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:57 pm
TYS
- STL
1 stop4h 21m
United Airlines
Sat 5/301:13 pm
STL
- TYS
1 stop6h 43m
United Airlines
Deal found 3/7![United Airlines logo]()
$268
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/195:40 am
TYS
- STL
1 stop5h 54m
Delta
Sat 4/256:00 am
STL
- TYS
1 stop4h 17m
Delta
Deal found 3/4![Delta logo]()
$278
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/23:55 pm
TYS
- STL
1 stop5h 25m
Southwest
Mon 5/45:45 am
STL
- TYS
1 stop7h 25m
Southwest
Deal found 3/4![Southwest logo]()
$254
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:55 pm
TYS
- STL
1 stop4h 21m
United Airlines
Mon 7/66:55 pm
STL
- TYS
1 stop4h 35m
United Airlines
Deal found 3/8![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/267:25 pm
TYS
- STL
1 stop5h 40m
Southwest
Sat 3/2812:40 pm
STL
- TYS
1 stop8h 30m
Southwest
Deal found 3/4![Southwest logo]()
$262
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:40 am
TYS
- STL
2 stops8h 40m
Southwest
Sun 5/38:30 am
STL
- TYS
1 stop5h 45m
Southwest
Deal found 3/6![Southwest logo]()
$273
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/233:55 pm
TYS
- STL
1 stop5h 25m
Southwest
Sat 5/3010:35 am
STL
- TYS
2 stops6h 55m
Southwest
Deal found 3/7![Southwest logo]()
$273
Last-minute flights from Knoxville to St. LouisDiscover last-minute flight deals from Knoxville to St. Louis. Data last updated March 9, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to St. Louis. Data last updated March 9, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:20 pm
TYS
- STL
1 stop5h 20m
Southwest
Sat 3/2812:40 pm
STL
- TYS
1 stop8h 30m
Southwest
Deal found 3/4![Southwest logo]()
$250
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/267:25 pm
TYS
- STL
1 stop5h 40m
Southwest
Sat 3/2812:40 pm
STL
- TYS
1 stop8h 30m
Southwest
Deal found 3/4![Southwest logo]()
$262
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/112:21 pm
TYS
- STL
1 stop8h 08m
American Airlines
Thu 4/25:12 am
STL
- TYS
1 stop5h 18m
American Airlines
Deal found 3/5![American Airlines logo]()
$265
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:35 am
TYS
- STL
2 stops9h 05m
Southwest
Thu 4/210:25 am
STL
- TYS
1 stop7h 20m
Southwest
Deal found 3/5![Southwest logo]()
$280
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:30 am
TYS
- STL
2 stops7h 00m
Southwest
Thu 4/910:50 am
STL
- TYS
2 stops8h 30m
Southwest
Deal found 3/5![Southwest logo]()
$267
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:05 am
TYS
- STL
2 stops8h 20m
Southwest
Sun 4/197:35 am
STL
- TYS
1 stop3h 05m
Southwest
Deal found 3/6![Southwest logo]()
$273
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:45 pm
TYS
- STL
1 stop5h 30m
Southwest
Sun 4/196:15 am
STL
- TYS
1 stop8h 00m
Southwest
Deal found 3/6![Southwest logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1911:27 am
TYS
- STL
2 stops33h 05m
Multiple Airlines
Sat 4/258:17 pm
STL
- TYS
1 stop18h 16m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$282
One-way flights from Knoxville to St. LouisSearch for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated March 9, 2026.
Search for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated March 9, 2026.
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:20 pm
TYS
- STL
1 stop5h 20m
Southwest
Deal found 3/4![Southwest logo]()
$117
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:40 am
TYS
- STL
1 stop4h 25m
Delta
Deal found 3/4![Delta logo]()
$129
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/263:45 pm
TYS
- STL
2 stops9h 20m
Southwest
Deal found 3/4![Southwest logo]()
$134
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/197:00 am
TYS
- STL
1 stop6h 48m
American Airlines
Deal found 3/7![American Airlines logo]()
$140
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:35 am
TYS
- STL
2 stops7h 15m
Southwest
Deal found 3/4![Southwest logo]()
$145
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/195:40 am
TYS
- STL
1 stop3h 50m
Delta
Deal found 3/5![Delta logo]()
$151
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/273:45 pm
TYS
- STL
1 stop7h 25m
Southwest
Deal found 3/4![Southwest logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1911:27 am
TYS
- STL
3 stops33h 05m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$188
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/193:50 pm
TYS
- STL
2 stops9h 25m
Southwest
Deal found 3/8![Southwest logo]()
$200
Find flight deals from Knoxville to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $238 (Southwest) |
One-way from | $117 (Southwest) |
Popular in | November |
Cheapest in | June |
Average price | $417 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 9, 2026.
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Wed 3/25
6:20 pm-10:40 pm
1 stop5h 20m
Lambert-St Louis
Sat 3/28
12:40 pm-10:10 pm
1 stop8h 30m
$250
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sat 5/2
3:55 pm-8:20 pm
1 stop5h 25m
Lambert-St Louis
Mon 5/4
5:45 am-2:10 pm
1 stop7h 25m
$254
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Thu 3/26
7:25 pm-12:05 am
1 stop5h 40m
Lambert-St Louis
Sat 3/28
12:40 pm-10:10 pm
1 stop8h 30m
$262
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sat 5/23
5:57 pm-9:18 pm
1 stop4h 21m
Lambert-St Louis
Sat 5/30
1:13 pm-8:56 pm
1 stop6h 43m
$268
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sat 5/2
6:40 am-2:20 pm
2 stops8h 40m
Lambert-St Louis
Sun 5/3
8:30 am-3:15 pm
1 stop5h 45m
$273
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sat 5/23
3:55 pm-8:20 pm
1 stop5h 25m
Lambert-St Louis
Sat 5/30
10:35 am-6:30 pm
2 stops6h 55m
$273
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sun 4/19
5:40 am-10:34 am
1 stop5h 54m
Lambert-St Louis
Sat 4/25
6:00 am-11:17 am
1 stop4h 17m
$278
Quickest round-trip
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Tue 6/30
5:55 pm-9:16 pm
1 stop4h 21m
Lambert-St Louis
Mon 7/6
6:55 pm-12:30 am
1 stop4h 35m
$279
Cheapest one-way
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Wed 4/29
2:55 pm-9:15 pm
1 stop7h 20m
$117
Quickest one-way
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Thu 3/26
5:40 am-9:05 am
1 stop4h 25m
$129
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Knoxville to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to St. Louis in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.
TYS-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to St. Louis
Prices
More
What’s the top layover airport for flights from Knoxville to St. Louis?
Share of 1-stop round-trip flights from Knoxville to St. Louis chosen by Cheapflights users in the past 12 months, using the same layover each way.
Chicago (ORD) – chosen by Cheapflights users on 50% of 1-stop itineraries from Knoxville to St. Louis on Cheapflights.
What’s the cheapest layover airport for flights from Knoxville to St. Louis?
Average round-trip fare for 1-stop flights from Knoxville to St. Louis, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Charlotte (CLT) is the most affordable 1-stop option, with an average round-trip price of $167.
What’s the fastest layover option from Knoxville to St. Louis?
Shortest average travel time for 1-stop one-way flights from Knoxville to St. Louis, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Charlotte (CLT) have the shortest average one-way travel time for 1-stop routes: 4h 35m.
Which airport typically offers the quickest layover for flights from Knoxville to St. Louis?
Average layover duration for 1-stop one-way flights from Knoxville to St. Louis, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Charlotte (CLT) offer the fastest connection on this route, with an average layover time of 0h 58m.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated March 9, 2026.
Read through reviews of airlines operating flights from Knoxville to St. Louis, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Entertainment
7.8
Crew
8.5
Boarding
8.1
Comfort
7.9
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Entertainment
7.8
Crew
8.5
Boarding
8.1
Comfort
7.9
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Entertainment
7.8
Crew
8.5
Boarding
8.1
Comfort
7.9
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
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Find flights from Knoxville to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and St. Louis flights
Browse other Knoxville and St. Louis flight options. Last updated on March 9, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on March 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 9, 2026.
Top 2 airlines flying from Knoxville to St. Louis
Discover the top 2 airlines that operate flights from Knoxville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$198 | Average$357 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$228 | Average$302 | FlexibilityNo cancel fee | On-timeN/A |