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$117+ Cheap flights from Knoxville to St. Louis (TYS - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Knoxville to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$234
(Kiwi.com)

One-way from

$117
(Kiwi.com)

Popular in

March

Cheapest in

April

Average price

$316
From Knoxville McGhee Tyson to Lambert-St Louis
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One-way flight from Knoxville McGhee Tyson to Lambert-St Louis
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Highest demand for flights based on searches. 10% potential increase in price ($41 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to St. Louis

Cheapest flights from Knoxville to St. Louis
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/235:34 pmTYS - STL
2 stops16h 33mMultiple Airlines
Sat 10/257:52 pmSTL - TYS
1 stop16h 41mMultiple Airlines
Deal found 9/15$234
This Flightnetwork deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/258:40 pmTYS - STL
1 stop13h 26mFrontier
Sat 9/277:55 pmSTL - TYS
1 stop19h 23mFrontier
Deal found 9/16$247
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/237:45 amTYS - STL
1 stop6h 37mDelta
Sat 10/256:00 amSTL - TYS
1 stop3h 28mDelta
Deal found 9/15$249
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:00 amTYS - STL
1 stop7h 51mAmerican Airlines
Sun 10/57:22 amSTL - TYS
1 stop5h 32mAmerican Airlines
Deal found 9/15$259
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/154:26 pmTYS - STL
1 stop18h 36mMultiple Airlines
Fri 10/1710:59 pmSTL - TYS
1 stop21h 05mMultiple Airlines
Deal found 9/16$262
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/155:44 amTYS - STL
1 stop5h 42mDelta
Fri 10/176:52 pmSTL - TYS
1 stop3h 54mDelta
Deal found 9/17$265
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/235:34 pmTYS - STL
2 stops16h 33mMultiple Airlines
Sun 10/2610:57 amSTL - TYS
1 stop8h 28mMultiple Airlines
Deal found 9/15$267
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/235:34 pmTYS - STL
2 stops16h 33mMultiple Airlines
Wed 10/298:40 pmSTL - TYS
1 stop15h 53mMultiple Airlines
Deal found 9/15$268
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:03 amTYS - STL
1 stop5h 21mAmerican Airlines
Sun 10/195:11 amSTL - TYS
1 stop5h 33mAmerican Airlines
Deal found 9/15$269
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:45 amTYS - STL
1 stop3h 29mDelta
Mon 9/295:11 pmSTL - TYS
1 stop3h 15mDelta
Deal found 9/14$274
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/77:45 amTYS - STL
1 stop6h 37mDelta
Mon 11/102:36 pmSTL - TYS
1 stop4h 24mDelta
Deal found 9/15$284
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/257:00 amTYS - STL
1 stop27h 06mMultiple Airlines
Mon 9/294:00 pmSTL - TYS
2 stops17h 35mMultiple Airlines
Deal found 9/14$287

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Fly from

Knoxville

Fly to

St. Louis

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 10/23

5:34 pm-9:07 am

2 stops16h 33m

Lambert-St Louis

Sat 10/25

7:52 pm-1:33 pm

1 stop16h 41m

$234

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 10/14

5:44 am-10:26 am

1 stop5h 42m

Lambert-St Louis

Tue 10/21

5:15 pm-11:07 pm

1 stop4h 52m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 11/7

11:22 am-4:36 pm

1 stop6h 14m

Lambert-St Louis

Mon 11/10

5:58 pm-12:08 am

1 stop5h 10m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 10/23

5:44 am-8:05 am

1 stop3h 21m

Lambert-St Louis

Sun 10/26

6:00 am-10:36 am

1 stop3h 36m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 10/23

7:45 am-1:22 pm

1 stop6h 37m

Lambert-St Louis

Sat 10/25

6:00 am-10:28 am

1 stop3h 28m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 10/15

7:45 am-1:22 pm

1 stop6h 37m

Lambert-St Louis

Wed 10/22

9:10 am-2:43 pm

1 stop4h 33m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 10/23

7:45 am-1:22 pm

1 stop6h 37m

Lambert-St Louis

Wed 10/29

3:59 pm-11:07 pm

1 stop6h 08m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 10/17

8:10 pm-11:41 pm

1 stop4h 31m

Lambert-St Louis

Mon 10/20

5:15 pm-11:46 pm

1 stop5h 31m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sun 11/23

7:39 am-1:51 pm

1 stop7h 12m

Lambert-St Louis

Mon 12/1

5:12 pm-11:52 pm

1 stop5h 40m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 10/10

5:44 am-8:07 am

1 stop3h 23m

Lambert-St Louis

Mon 10/13

6:00 am-10:45 am

1 stop3h 45m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 20 results
1
2

Best time to book a flight from Knoxville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to St. Louis

What is the cheapest month to book a flight from Knoxville to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $311). Flying from Knoxville to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to STL?

Find hourly flight availability from Knoxville to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 8% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 17, 2025.
Read through reviews of airlines operating flights from Knoxville to St. Louis, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to St. Louis?

    Airlines like Delta and American Airlines fly from Knoxville to St. Louis in about 5h 42m. The time it takes to get you to your destination can typically vary by up to 32m. Knoxville and St. Louis are separated by a distance of 405 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to St. Louis round-trip?

    Cheapflights users have booked flights from Knoxville to St. Louis round-trip from $198. Other airlines that can offer you cheap pricing are United Airlines, from $213, and Delta, from $228. These flights start at 40% lower than the current average price 3 months from now.

  • Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?

    Yes. In addition to deals on Knoxville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to St. Louis.

  • Can I find deals for business class flights from Knoxville to St. Louis?

    Yes. Cheapflights offers flight deals from Knoxville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $311). Flying from Knoxville to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Knoxville to St. Louis

Discover the top 3 airlines that operate flights from Knoxville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$314FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$213Average$288FlexibilityNo cancel feeOn-time69%
DeltaCheapest$228Average$302FlexibilityNo cancel feeOn-timeN/A

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