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$126+ Cheap flights from Knoxville to St. Louis (TYS - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Dec 20 — Dec 271
Sat 12/20
Sat 12/27
1 adult, Economy
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Find flight deals from Knoxville to St. Louis

Cheapest flights from Knoxville to St. Louis
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 20, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/412:31 pmTYS - STL
1 stop11h 02mMultiple Airlines
Sun 12/79:54 amSTL - TYS
1 stop10h 50mMultiple Airlines
Deal found 11/17$257
This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/121:05 pmTYS - STL
1 stop10h 28mMultiple Airlines
Sun 12/1410:42 amSTL - TYS
2 stops28h 15mMultiple Airlines
Deal found 11/18$264
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:40 pmTYS - STL
1 stop7h 15mAmerican Airlines
Tue 1/69:25 amSTL - TYS
1 stop5h 21mAmerican Airlines
Deal found 11/19$295
This Delta deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/95:40 amTYS - STL
1 stop3h 44mDelta
Fri 12/127:02 pmSTL - TYS
1 stop3h 26mDelta
Deal found 11/18$304
This Kiwi.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/151:05 pmTYS - STL
1 stop10h 28mMultiple Airlines
Mon 12/2210:40 amSTL - TYS
1 stop10h 13mMultiple Airlines
Deal found 11/17$323
This Delta deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/35:40 amTYS - STL
1 stop3h 44mDelta
Sun 12/77:05 amSTL - TYS
1 stop5h 39mDelta
Deal found 11/18$329
This Delta deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/75:40 amTYS - STL
1 stop3h 44mDelta
Tue 12/99:30 amSTL - TYS
1 stop4h 22mDelta
Deal found 11/19$334
This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:53 pmTYS - STL
2 stops23h 14mMultiple Airlines
Sun 12/79:14 pmSTL - TYS
1 stop18h 48mMultiple Airlines
Deal found 11/18$340
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:40 amTYS - STL
1 stop6h 05mDelta
Mon 12/1511:40 amSTL - TYS
1 stop6h 12mDelta
Deal found 11/17$347
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:23 amTYS - STL
1 stop6h 27mAmerican Airlines
Sun 12/216:35 pmSTL - TYS
1 stop4h 12mAmerican Airlines
Deal found 11/17$358

Cheap flight deals from Knoxville to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 20, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$257
(Kiwi.com)

One-way from

$126
(Delta)

Popular in

March

Cheapest in

April

Average price

$351
Provider with most accurate pricing for Knoxville McGhee Tyson-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Lambert-St Louis flights.
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From Knoxville McGhee Tyson to Lambert-St Louis
Search Deals
One-way flight from Knoxville McGhee Tyson to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($30 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Fly from

Knoxville

Fly to

St. Louis

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 12/4

12:31 pm-10:33 pm

1 stop11h 02m

Lambert-St Louis

Sun 12/7

9:54 am-9:44 pm

1 stop10h 50m

$257

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 1/31

11:58 am-3:56 pm

1 stop4h 58m

Lambert-St Louis

Mon 2/2

9:59 am-3:19 pm

1 stop4h 20m

$265

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 1/31

10:11 am-5:01 pm

2 stops7h 50m

Lambert-St Louis

Mon 2/2

3:54 pm-10:54 pm

1 stop6h 00m

$270

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 12/9

5:40 am-8:24 am

1 stop3h 44m

Lambert-St Louis

Fri 12/12

7:02 pm-11:28 pm

1 stop3h 26m

$304

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 12/17

5:40 am-10:45 am

1 stop6h 05m

Lambert-St Louis

Thu 12/18

9:30 am-1:44 pm

1 stop3h 14m

$304

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Mon 12/15

1:05 pm-10:33 pm

1 stop10h 28m

Lambert-St Louis

Mon 12/22

10:40 am-9:53 pm

1 stop10h 13m

$323

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 12/6

7:33 am-12:40 pm

1 stop6h 07m

Lambert-St Louis

Sun 12/7

6:00 am-10:46 am

1 stop3h 46m

$329

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 12/3

5:40 am-8:24 am

1 stop3h 44m

Lambert-St Louis

Sun 12/7

7:05 am-1:44 pm

1 stop5h 39m

$329

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 12/5

5:54 pm-9:02 pm

1 stop4h 08m

Lambert-St Louis

Tue 12/9

11:40 am-4:53 pm

1 stop4h 13m

$329

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sun 12/7

5:40 am-8:24 am

1 stop3h 44m

Lambert-St Louis

Tue 12/9

9:30 am-2:52 pm

1 stop4h 22m

$334

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/18

Showing 1-10 of 22 results
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Compare providers for flights from Knoxville to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to St. Louis in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to St. Louis

What is the cheapest month to book a flight from Knoxville to St. Louis?

Currently, April is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $198). Flying from Knoxville to St. Louis in November is currently the most expensive (average of $243). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to STL?

Find hourly flight availability from Knoxville to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 20, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 7% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated November 20, 2025.
Read through reviews of airlines operating flights from Knoxville to St. Louis, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,002 reviews
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,029 reviews
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,047 reviews
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to St. Louis?

    Airlines like Delta and American Airlines fly from Knoxville to St. Louis in about 4h 58m. The time it takes to get you to your destination can typically vary by up to 2h 52m. Knoxville and St. Louis are separated by a distance of 405 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to St. Louis round-trip?

    Cheapflights users have booked flights from Knoxville to St. Louis round-trip from $198. Other airlines that can offer you cheap pricing are United Airlines, from $213, and Delta, from $228. These flights start at 41% lower than the current average price 3 months from now.

  • Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?

    Yes. In addition to deals on Knoxville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to St. Louis.

  • Can I find deals for business class flights from Knoxville to St. Louis?

    Yes. Cheapflights offers flight deals from Knoxville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to St. Louis?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $198). Flying from Knoxville to St. Louis in November is currently the most expensive (average of $243). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Knoxville to St. Louis

Discover the top 3 airlines that operate flights from Knoxville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$332FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$213Average$308FlexibilityNo cancel feeOn-time69%
DeltaCheapest$228Average$302FlexibilityNo cancel feeOn-timeN/A

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