$121+ Cheap flights from Knoxville to St. Louis (TYS - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/24. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Jul 5 — Jul 121
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to St. Louis
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Best
Last-minute
One-way
Cheapest flights from Knoxville to St. LouisExplore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 5, 2026.
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 5, 2026.
This Booking.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/18:32 pm
TYS
- STL
1 stop23h 21m
Frontier
Tue 7/78:08 pm
STL
- TYS
1 stop22h 16m
Frontier
Deal found 6/2![Frontier logo]()
$242
This Mytrip deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/178:19 pm
TYS
- STL
1 stop24h 04m
Frontier
Tue 7/218:08 pm
STL
- TYS
1 stop22h 16m
Frontier
Deal found 6/4![Frontier logo]()
$259
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 pm
TYS
- STL
1 stop7h 15m
Southwest
Tue 7/73:10 pm
STL
- TYS
1 stop4h 15m
Southwest
Deal found 5/31![Southwest logo]()
$269
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:10 am
TYS
- STL
2 stops6h 55m
Southwest
Tue 7/78:25 am
STL
- TYS
1 stop8h 55m
Southwest
Deal found 6/2![Southwest logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/163:53 pm
TYS
- STL
1 stop9h 06m
Multiple Airlines
Sun 7/196:34 pm
STL
- TYS
2 stops26h 26m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$285
This Southwest deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:40 am
TYS
- STL
2 stops7h 05m
Southwest
Tue 7/218:25 am
STL
- TYS
1 stop8h 55m
Southwest
Deal found 6/4![Southwest logo]()
$289
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:45 pm
TYS
- STL
1 stop4h 05m
Southwest
Mon 7/205:35 pm
STL
- TYS
1 stop2h 40m
Southwest
Deal found 6/1![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/24:20 pm
TYS
- STL
1 stop7h 20m
Southwest
Sun 7/59:15 am
STL
- TYS
1 stop5h 30m
Southwest
Deal found 6/1![Southwest logo]()
$299
Best flights from Knoxville to St. LouisDiscover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 5, 2026.
Discover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 5, 2026.
This Booking.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/18:32 pm
TYS
- STL
1 stop23h 21m
Frontier
Tue 7/78:08 pm
STL
- TYS
1 stop22h 16m
Frontier
Deal found 6/2![Frontier logo]()
$242
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 pm
TYS
- STL
1 stop7h 15m
Southwest
Tue 7/73:10 pm
STL
- TYS
1 stop4h 15m
Southwest
Deal found 5/31![Southwest logo]()
$269
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:10 am
TYS
- STL
2 stops6h 55m
Southwest
Tue 7/78:25 am
STL
- TYS
1 stop8h 55m
Southwest
Deal found 6/2![Southwest logo]()
$274
This Southwest deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:40 am
TYS
- STL
2 stops7h 05m
Southwest
Tue 7/218:25 am
STL
- TYS
1 stop8h 55m
Southwest
Deal found 6/4![Southwest logo]()
$289
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/87:25 pm
TYS
- STL
1 stop5h 30m
Southwest
Mon 11/94:30 pm
STL
- TYS
1 stop3h 00m
Southwest
Deal found 5/31![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:10 am
TYS
- STL
1 stop7h 30m
Southwest
Mon 11/94:30 pm
STL
- TYS
1 stop3h 00m
Southwest
Deal found 5/31![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:40 am
TYS
- STL
2 stops7h 05m
Southwest
Sun 7/198:00 am
STL
- TYS
1 stop6h 45m
Southwest
Deal found 6/1![Southwest logo]()
$304
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:45 pm
TYS
- STL
1 stop4h 05m
Southwest
Sun 7/1211:45 am
STL
- TYS
2 stops9h 45m
Southwest
Deal found 6/1![Southwest logo]()
$304
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/187:00 am
TYS
- STL
2 stops11h 25m
Southwest
Mon 7/2012:40 pm
STL
- TYS
2 stops8h 55m
Southwest
Deal found 6/1![Southwest logo]()
$325
Last-minute flights from Knoxville to St. LouisDiscover last-minute flight deals from Knoxville to St. Louis. Data last updated June 5, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to St. Louis. Data last updated June 5, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 pm
TYS
- STL
1 stop7h 15m
Southwest
Tue 7/73:10 pm
STL
- TYS
1 stop4h 15m
Southwest
Deal found 5/31![Southwest logo]()
$269
This Booking.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/18:32 pm
TYS
- STL
1 stop23h 21m
Frontier
Tue 7/78:08 pm
STL
- TYS
1 stop22h 16m
Frontier
Deal found 6/2![Frontier logo]()
$242
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:10 am
TYS
- STL
2 stops6h 55m
Southwest
Tue 7/78:25 am
STL
- TYS
1 stop8h 55m
Southwest
Deal found 6/2![Southwest logo]()
$274
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/24:20 pm
TYS
- STL
1 stop7h 20m
Southwest
Sun 7/59:15 am
STL
- TYS
1 stop5h 30m
Southwest
Deal found 6/1![Southwest logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/163:53 pm
TYS
- STL
1 stop9h 06m
Multiple Airlines
Sun 7/196:34 pm
STL
- TYS
2 stops26h 26m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$285
This Mytrip deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/178:19 pm
TYS
- STL
1 stop24h 04m
Frontier
Tue 7/218:08 pm
STL
- TYS
1 stop22h 16m
Frontier
Deal found 6/4![Frontier logo]()
$259
This Southwest deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:40 am
TYS
- STL
2 stops7h 05m
Southwest
Tue 7/218:25 am
STL
- TYS
1 stop8h 55m
Southwest
Deal found 6/4![Southwest logo]()
$289
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:45 pm
TYS
- STL
1 stop4h 05m
Southwest
Mon 7/205:35 pm
STL
- TYS
1 stop2h 40m
Southwest
Deal found 6/1![Southwest logo]()
$294
One-way flights from Knoxville to St. LouisSearch for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 5, 2026.
Search for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 5, 2026.
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:52 pm
TYS
- STL
1 stop6h 22m
American Airlines
Deal found 5/30![American Airlines logo]()
$121
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:45 pm
TYS
- STL
2 stops6h 20m
Southwest
Deal found 6/1![Southwest logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1712:40 pm
TYS
- STL
2 stops21h 17m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:51 pm
TYS
- STL
2 stops27h 39m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$139
This Booking.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/178:19 pm
TYS
- STL
1 stop24h 04m
Frontier
Deal found 6/2![Frontier logo]()
$147
This deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:00 am
TYS
- STL
1 stop6h 02m
United Airlines
Deal found 6/1![United Airlines logo]()
$178
This deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:45 pm
TYS
- STL
1 stop4h 41m
United Airlines
Deal found 6/3![United Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/142:14 pm
TYS
- STL
3 stops52h 16m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/145:37 am
TYS
- STL
1 stop8h 12m
American Airlines
Deal found 6/2![American Airlines logo]()
$314
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/147:05 am
TYS
- STL
2 stops6h 40m
Southwest
Deal found 6/2![Southwest logo]()
$319
Find flight deals from Knoxville to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $242 (Booking.com) |
One-way from | $121 (American Airlines) |
Popular in | November |
Cheapest in | January |
Average price | $300 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 5, 2026.
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Wed 7/1
8:32 pm-6:53 pm
1 stop23h 21m
Lambert-St Louis
Tue 7/7
8:08 pm-7:24 pm
1 stop22h 16m
$242
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Tue 6/30
5:40 pm-11:55 pm
1 stop7h 15m
Lambert-St Louis
Tue 7/7
3:10 pm-8:25 pm
1 stop4h 15m
$269
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Wed 7/1
7:10 am-1:05 pm
2 stops6h 55m
Lambert-St Louis
Tue 7/7
8:25 am-6:20 pm
1 stop8h 55m
$274
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Fri 7/17
6:40 am-12:45 pm
2 stops7h 05m
Lambert-St Louis
Tue 7/21
8:25 am-6:20 pm
1 stop8h 55m
$289
Quickest round-trip
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sun 11/8
7:25 pm-11:55 pm
1 stop5h 30m
Lambert-St Louis
Mon 11/9
4:30 pm-8:30 pm
1 stop3h 00m
$294
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Fri 11/6
8:10 am-2:40 pm
1 stop7h 30m
Lambert-St Louis
Mon 11/9
4:30 pm-8:30 pm
1 stop3h 00m
$294
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Fri 7/17
6:40 am-12:45 pm
2 stops7h 05m
Lambert-St Louis
Sun 7/19
8:00 am-3:45 pm
1 stop6h 45m
$304
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Fri 7/10
7:45 pm-10:50 pm
1 stop4h 05m
Lambert-St Louis
Sun 7/12
11:45 am-10:30 pm
2 stops9h 45m
$304
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sat 7/18
7:00 am-5:25 pm
2 stops11h 25m
Lambert-St Louis
Mon 7/20
12:40 pm-10:35 pm
2 stops8h 55m
$325
Cheapest one-way
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Mon 8/24
6:52 pm-12:14 am
1 stop6h 22m
$121
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Knoxville to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to St. Louis in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.
TYS-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to St. Louis
What is the cheapest month to book a flight from Knoxville to St. Louis?
Currently, January is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $294). Flying from Knoxville to St. Louis in November is currently the most expensive (average of $553). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to St. Louis?
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated June 5, 2026.
Read through reviews of airlines operating flights from Knoxville to St. Louis, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsO'Fallon
Edwardsville
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
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Knoxville and St. Louis flights
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Other flights from Knoxville
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Other flights to St. Louis
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Top 2 airlines flying from Knoxville to St. Louis
Discover the top 2 airlines that operate flights from Knoxville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$363 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$302 | FlexibilityNo cancel fee | On-timeN/A |