$64+ Cheap flights from Maine to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — CHS
May 2 — May 91
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Maine to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Maine to South Carolina
Cheapest
Best
Last-minute
One-way
Cheapest flights from Maine to South CarolinaExplore the most affordable flight options available from Maine to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2026.
Explore the most affordable flight options available from Maine to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:25 pm
BOS
- MYR
Nonstop2h 12m
Spirit Airlines
Tue 4/285:45 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/1![Spirit Airlines logo]()
$128
This Priceline deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:00 pm
BOS
- MYR
Nonstop2h 12m
Spirit Airlines
Sat 5/25:45 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/2![Spirit Airlines logo]()
$129
This Cheapflightsfares deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:29 pm
BOS
- MYR
Nonstop2h 19m
Spirit Airlines
Mon 4/133:29 pm
MYR
- BOS
Nonstop2h 04m
Spirit Airlines
Deal found 3/30![Spirit Airlines logo]()
$132
This Cheapflightsfares deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:25 pm
BOS
- MYR
Nonstop2h 12m
Spirit Airlines
Tue 5/510:55 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/2![Spirit Airlines logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:42 am
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Sat 5/25:45 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/1![Spirit Airlines logo]()
$136
This Cheapflightsfares deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:29 pm
BOS
- MYR
Nonstop2h 19m
Spirit Airlines
Tue 4/143:29 pm
MYR
- BOS
Nonstop2h 04m
Spirit Airlines
Deal found 3/30![Spirit Airlines logo]()
$137
This Cheapflightsfares deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/258:42 am
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Sat 5/25:45 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 3/31![Spirit Airlines logo]()
$138
This CheapOair deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2612:22 pm
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Wed 4/295:45 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/1![Spirit Airlines logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:42 am
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Wed 5/610:55 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/2![Spirit Airlines logo]()
$141
This Cheapflightsfares deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:29 pm
BOS
- MYR
Nonstop2h 19m
Spirit Airlines
Tue 4/215:45 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 3/30![Spirit Airlines logo]()
$143
This Priceline deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:22 pm
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Tue 5/1210:55 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/2![Spirit Airlines logo]()
$144
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:00 am
BOS
- SAV
2 stops10h 40m
Southwest
Wed 5/61:05 pm
SAV
- BOS
1 stop6h 35m
Southwest
Deal found 3/30![Southwest logo]()
$202
Best flights from Maine to South CarolinaDiscover carefully curated flight deals from Maine to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 2, 2026.
Discover carefully curated flight deals from Maine to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 2, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:29 pm
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Tue 6/910:55 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/2![Spirit Airlines logo]()
$168
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:20 am
BOS
- SAV
1 stop4h 35m
Southwest
Wed 5/66:40 am
SAV
- BOS
2 stops9h 15m
Southwest
Deal found 3/30![Southwest logo]()
$202
This Breeze Airways deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:00 am
PWM
- SAV
1 stop4h 43m
Breeze Airways
Wed 9/164:55 pm
SAV
- PWM
1 stop4h 24m
Breeze Airways
Deal found 3/31![Breeze Airways logo]()
$205
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:45 am
BOS
- CHS
1 stop4h 28m
United Airlines
Sat 5/237:47 pm
CHS
- BOS
1 stop4h 12m
United Airlines
Deal found 4/1![United Airlines logo]()
$242
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:00 pm
BOS
- CHS
1 stop6h 15m
Delta
Sat 6/64:55 pm
CHS
- BOS
1 stop5h 23m
Delta
Deal found 3/29![Delta logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/29:20 am
BOS
- MYR
1 stop23h 45m
Multiple Airlines
Tue 6/910:55 am
MYR
- BOS
Nonstop2h 02m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$261
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1110:48 am
PWM
- SAV
1 stop7h 28m
American Airlines
Wed 5/136:57 pm
SAV
- PWM
1 stop4h 30m
American Airlines
Deal found 3/28![American Airlines logo]()
$291
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/43:50 pm
BOS
- SAV
1 stop5h 25m
Southwest
Sat 5/97:00 pm
SAV
- BOS
1 stop4h 40m
Southwest
Deal found 4/2![Southwest logo]()
$217
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:51 am
BOS
- CHS
1 stop7h 12m
Delta
Mon 5/117:59 pm
CHS
- BOS
1 stop5h 24m
Delta
Deal found 3/30![Delta logo]()
$242
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/29:10 am
BOS
- CHS
1 stop7h 05m
Southwest
Sat 5/97:00 am
CHS
- BOS
1 stop5h 00m
Southwest
Deal found 4/2![Southwest logo]()
$237
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/38:00 am
BOS
- CAE
1 stop7h 07m
Delta
Wed 6/174:05 pm
CAE
- BOS
1 stop7h 22m
Delta
Deal found 3/28![Delta logo]()
$251
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/29:30 am
BOS
- CHS
1 stop4h 46m
United Airlines
Wed 6/311:31 am
CHS
- BOS
2 stops12h 28m
United Airlines
Deal found 3/31![United Airlines logo]()
$282
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:45 am
BOS
- CHS
2 stops9h 35m
Southwest
Wed 6/32:25 pm
CHS
- BOS
1 stop5h 15m
Southwest
Deal found 4/2![Southwest logo]()
$247
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:00 am
BOS
- CHS
2 stops8h 59m
United Airlines
Tue 5/121:19 pm
CHS
- BOS
1 stop6h 07m
United Airlines
Deal found 3/29![United Airlines logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:45 am
BOS
- GSP
1 stop9h 59m
Multiple Airlines
Mon 5/258:23 am
GSP
- BOS
1 stop13h 19m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/24:30 pm
BOS
- SAV
1 stop7h 29m
Delta
Mon 5/47:59 pm
SAV
- BOS
1 stop5h 23m
Delta
Deal found 3/29![Delta logo]()
$287
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:45 am
BOS
- SAV
1 stop4h 59m
United Airlines
Tue 5/1912:19 pm
SAV
- BOS
2 stops11h 40m
United Airlines
Deal found 3/29![United Airlines logo]()
$292
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/2310:20 am
BOS
- MYR
Nonstop2h 28m
Delta
Fri 8/286:45 pm
MYR
- BOS
1 stop6h 21m
Delta
Deal found 3/30![Delta logo]()
$289
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/297:05 am
BOS
- CAE
2 stops9h 50m
United Airlines
Wed 5/67:38 pm
CAE
- BOS
1 stop4h 21m
United Airlines
Deal found 4/1![United Airlines logo]()
$295
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:30 pm
BOS
- MYR
1 stop6h 20m
Southwest
Sat 5/167:15 pm
MYR
- BOS
1 stop4h 25m
Southwest
Deal found 3/29![Southwest logo]()
$299
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:40 am
BOS
- MYR
1 stop4h 57m
Delta
Sat 6/61:55 pm
MYR
- BOS
Nonstop2h 15m
Delta
Deal found 3/30![Delta logo]()
$289
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/113:39 pm
PWM
- SAV
2 stops8h 20m
United Airlines
Wed 5/137:15 pm
SAV
- PWM
1 stop4h 44m
United Airlines
Deal found 4/1![United Airlines logo]()
$301
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/35:30 am
BOS
- MYR
1 stop4h 15m
Southwest
Fri 5/83:45 pm
MYR
- BOS
2 stops8h 10m
Southwest
Deal found 3/31![Southwest logo]()
$304
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2410:05 am
BOS
- SAV
2 stops11h 03m
United Airlines
Fri 5/15:45 am
SAV
- BOS
2 stops7h 06m
United Airlines
Deal found 4/2![United Airlines logo]()
$307
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:55 pm
BOS
- SAV
1 stop6h 00m
Southwest
Sun 6/147:35 pm
SAV
- BOS
1 stop4h 30m
Southwest
Deal found 3/28![Southwest logo]()
$307
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:20 pm
BOS
- CLT
Nonstop2h 41m
Delta
Tue 5/269:45 am
CLT
- BOS
1 stop6h 15m
Delta
Deal found 3/28![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:45 am
BOS
- CHS
2 stops8h 06m
United Airlines
Sat 5/96:00 am
CHS
- BOS
2 stops7h 51m
United Airlines
Deal found 4/1![United Airlines logo]()
$307
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:55 pm
BOS
- MYR
2 stops7h 35m
Southwest
Tue 6/910:25 am
MYR
- BOS
2 stops10h 55m
Southwest
Deal found 4/2![Southwest logo]()
$315
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:45 pm
BOS
- MYR
1 stop5h 54m
Delta
Sun 9/201:15 pm
MYR
- BOS
Nonstop2h 13m
Delta
Deal found 4/1![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2011:40 am
BOS
- CHS
2 stops9h 25m
Southwest
Sat 5/236:45 pm
CHS
- BOS
1 stop4h 55m
Southwest
Deal found 4/1![Southwest logo]()
$317
Last-minute flights from Maine to South CarolinaDiscover last-minute flight deals from Maine to South Carolina. Data last updated April 2, 2026 and is based on user searches.
Discover last-minute flight deals from Maine to South Carolina. Data last updated April 2, 2026 and is based on user searches.
This Cheapflightsfares deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:29 pm
BOS
- MYR
Nonstop2h 19m
Spirit Airlines
Mon 4/133:29 pm
MYR
- BOS
Nonstop2h 04m
Spirit Airlines
Deal found 3/30![Spirit Airlines logo]()
$132
This Cheapflightsfares deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:29 pm
BOS
- MYR
Nonstop2h 19m
Spirit Airlines
Tue 4/143:29 pm
MYR
- BOS
Nonstop2h 04m
Spirit Airlines
Deal found 3/30![Spirit Airlines logo]()
$137
This Cheapflightsfares deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:29 pm
BOS
- MYR
Nonstop2h 19m
Spirit Airlines
Tue 4/215:45 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 3/30![Spirit Airlines logo]()
$143
This Priceline deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:22 pm
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Tue 5/1210:55 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/2![Spirit Airlines logo]()
$144
This Cheapflightsfares deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:25 pm
BOS
- MYR
Nonstop2h 12m
Spirit Airlines
Tue 4/285:45 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/1![Spirit Airlines logo]()
$128
This Cheapflightsfares deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/258:42 am
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Sat 5/25:45 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 3/31![Spirit Airlines logo]()
$138
This CheapOair deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2612:22 pm
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Wed 4/295:45 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/1![Spirit Airlines logo]()
$139
This Priceline deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:00 pm
BOS
- MYR
Nonstop2h 12m
Spirit Airlines
Sat 5/25:45 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/2![Spirit Airlines logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:42 am
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Wed 5/610:55 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/2![Spirit Airlines logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:42 am
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Sat 5/25:45 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/1![Spirit Airlines logo]()
$136
This Cheapflightsfares deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:25 pm
BOS
- MYR
Nonstop2h 12m
Spirit Airlines
Tue 5/510:55 am
MYR
- BOS
Nonstop2h 02m
Spirit Airlines
Deal found 4/2![Spirit Airlines logo]()
$133
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:00 am
BOS
- SAV
2 stops10h 40m
Southwest
Wed 5/61:05 pm
SAV
- BOS
1 stop6h 35m
Southwest
Deal found 3/30![Southwest logo]()
$202
One-way flights from Maine to South CarolinaSearch for one-way flight options from Maine to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 2, 2026.
Search for one-way flight options from Maine to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:33 pm
BOS
- MYR
Nonstop2h 13m
Spirit Airlines
Deal found 4/1![Spirit Airlines logo]()
$64
This Super.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:42 am
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Deal found 4/1![Spirit Airlines logo]()
$69
This Flightnetwork deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:29 pm
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Deal found 4/2![Spirit Airlines logo]()
$70
This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:29 pm
BOS
- MYR
Nonstop2h 19m
Spirit Airlines
Deal found 3/31![Spirit Airlines logo]()
$74
This CheapOair deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2612:22 pm
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Deal found 4/2![Spirit Airlines logo]()
$75
This Super.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:29 pm
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Deal found 3/29![Spirit Airlines logo]()
$79
This Super.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:29 pm
BOS
- MYR
Nonstop2h 19m
Spirit Airlines
Deal found 4/2![Spirit Airlines logo]()
$83
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/112:22 pm
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Deal found 3/31![Spirit Airlines logo]()
$84
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:29 pm
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Deal found 4/2![Spirit Airlines logo]()
$89
This Cheapflightsfares deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/309:15 am
BOS
- MYR
Nonstop2h 15m
Spirit Airlines
Deal found 3/31![Spirit Airlines logo]()
$94
This Super.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:33 pm
BOS
- MYR
Nonstop2h 13m
Spirit Airlines
Deal found 4/2![Spirit Airlines logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2310:36 am
BOS
- GSP
1 stop6h 40m
Allegiant Air
Deal found 3/28![Allegiant Air logo]()
$100
Find flight deals from Maine to South Carolina
Keep the following information in mind while searching for Maine to South Carolina flight deals. Data was last updated April 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $128 (Cheapflightsfares) |
One-way from | $64 (Kiwi.com) |
Popular in | April |
Cheapest in | January |
Average price | $497 |
Good round-trip deal | $286 or less |
Good one-way deal | $89 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Maine to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2026.
Use the filters below to find and compare flights from Maine to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
BostonMyrtle Beach
BOS - MYR
BOSMYR
Boston Logan Intl
Tue 6/2
6:29 pm-8:44 pm
Nonstop2h 15m
Myrtle Beach Intl
Tue 6/9
10:55 am-12:57 pm
Nonstop2h 02m
$168
BostonSavannah
BOS - SAV
BOSSAV
Boston Logan Intl
Wed 4/29
6:20 am-10:55 am
1 stop4h 35m
Savannah/Hilton Head
Wed 5/6
6:40 am-3:55 pm
2 stops9h 15m
$202
PortlandSavannah
PWM - SAV
PWMSAV
Portland
Wed 9/9
7:00 am-11:43 am
1 stop4h 43m
Savannah/Hilton Head
Wed 9/16
4:55 pm-9:19 pm
1 stop4h 24m
$205
BostonSavannah
BOS - SAV
BOSSAV
Boston Logan Intl
Mon 5/4
3:50 pm-9:15 pm
1 stop5h 25m
Savannah/Hilton Head
Sat 5/9
7:00 pm-11:40 pm
1 stop4h 40m
$217
BostonCharleston
BOS - CHS
BOSCHS
Boston Logan Intl
Sat 5/2
9:10 am-4:15 pm
1 stop7h 05m
Charleston
Sat 5/9
7:00 am-12:00 pm
1 stop5h 00m
$237
BostonCharleston
BOS - CHS
BOSCHS
Boston Logan Intl
Wed 5/20
5:45 am-10:13 am
1 stop4h 28m
Charleston
Sat 5/23
7:47 pm-11:59 pm
1 stop4h 12m
$242
BostonCharleston
BOS - CHS
BOSCHS
Boston Logan Intl
Tue 6/2
12:00 pm-6:15 pm
1 stop6h 15m
Charleston
Sat 6/6
4:55 pm-10:18 pm
1 stop5h 23m
$242
BostonCharleston
BOS - CHS
BOSCHS
Boston Logan Intl
Sat 5/9
6:51 am-2:03 pm
1 stop7h 12m
Charleston
Mon 5/11
7:59 pm-1:23 am
1 stop5h 24m
$242
BostonCharleston
BOS - CHS
BOSCHS
Boston Logan Intl
Thu 5/28
8:45 am-6:20 pm
2 stops9h 35m
Charleston
Wed 6/3
2:25 pm-7:40 pm
1 stop5h 15m
$247
BostonColumbia
BOS - CAE
BOSCAE
Boston Logan Intl
Wed 6/3
8:00 am-3:07 pm
1 stop7h 07m
Columbia Metropolitan
Wed 6/17
4:05 pm-11:27 pm
1 stop7h 22m
$251
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Maine to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Maine with our price prediction graph.
BOS-MYR
BOS-GSP
BOS-CHS
BOS-SAV
PWM-SAV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Maine to South Carolina
USME-USSC
BOS-MYR
BOS-GSP
BOS-CHS
BOS-SAV
What is the cheapest month to book a flight from Maine to South Carolina?
Currently, April is the cheapest month in which you can book a flight from Maine to South Carolina (average of $64). Flying from Maine to South Carolina in October is currently the most expensive (average of $142). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from ME to SC?
Find hourly flight availability from Maine to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 2, 2026.
It’s optimal to fly from Maine to South Carolina in the evening. By choosing this option you can save up to 55% on the cost of your flight, compared to a flight in the afternoon.
How much does it cost to fly round-trip from Maine to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 2, 2026.
Get a feel of what it's like to fly with Breeze Airways,Southwest, andDelta from Maine to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.2
Food
6.6
Boarding
8.3
Overall
8.1
Entertainment
6.6
Crew
8.7
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Comfort
8.2
Food
6.6
Boarding
8.3
Overall
8.1
Entertainment
6.6
Crew
8.7
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Comfort
8.2
Food
6.6
Boarding
8.3
Overall
8.1
Entertainment
6.6
Crew
8.7
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Comfort
8.2
Food
6.6
Boarding
8.3
Overall
8.1
Entertainment
6.6
Crew
8.7
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Comfort
8.2
Food
6.6
Boarding
8.3
Overall
8.1
Entertainment
6.6
Crew
8.7
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Comfort
8.2
Food
6.6
Boarding
8.3
Overall
8.1
Entertainment
6.6
Crew
8.7
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Related info for your journey
Find useful and relevant information for your journey from Maine to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Return Flight Options
Top destinations
Alternative routes for Maine to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Maine to South Carolina by cabin class
Find flights from Maine to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Maine and South Carolina flights
Browse other Maine and South Carolina flight options. Last updated on April 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Maine after your stay in South Carolina
Maine to South Carolina flights
Consider these flights traveling from Maine to South Carolina.
Top 5 airlines flying from Maine to South Carolina
Discover the top 5 airlines that operate flights from Maine to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$93 | Average$207 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$138 | Average$317 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$223 | Average$388 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$256 | Average$426 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$277 | Average$531 | FlexibilityNo cancel fee | On-time69% |