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South Carolina

$80+ Cheap flights from Louisville (SDF) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/14. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — CHS
Jan 12 — Jan 191
Mon 1/12
Mon 1/19
1 adult, Economy
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Cheap flight deals from Louisville to South Carolina

Cheapest flights from Louisville to South Carolina
Explore the most affordable flight options available from Louisville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 13, 2025.

This Super.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:52 pmSDF - CHS
Nonstop1h 36mBreeze Airways
Fri 12/267:05 amCHS - SDF
Nonstop1h 53mBreeze Airways
Deal found 12/12$152
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:52 pmSDF - CHS
Nonstop1h 36mMultiple Airlines
Fri 12/2610:18 pmCHS - SDF
1 stop25h 41mMultiple Airlines
Deal found 12/10$209
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:05 amSDF - CAE
1 stop8h 42mMultiple Airlines
Tue 12/3010:02 pmCAE - SDF
2 stops25h 57mMultiple Airlines
Deal found 12/11$223
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:00 amSDF - SAV
1 stop6h 25mAmerican Airlines
Thu 1/14:27 pmSAV - SDF
1 stop5h 47mAmerican Airlines
Deal found 12/11$236
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:05 amSDF - CLT
1 stop18h 24mSpirit Airlines
Tue 12/309:38 pmCLT - SDF
1 stop26h 21mSpirit Airlines
Deal found 12/10$244
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:05 amSDF - CLT
1 stop15h 28mSpirit Airlines
Mon 12/299:38 pmCLT - SDF
1 stop25h 11mSpirit Airlines
Deal found 12/10$288
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:00 amSDF - CAE
1 stop3h 39mAmerican Airlines
Thu 1/12:48 pmCAE - SDF
1 stop6h 45mAmerican Airlines
Deal found 12/11$289
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:05 amSDF - CLT
1 stop15h 28mMultiple Airlines
Mon 12/299:43 pmCLT - SDF
2 stops16h 32mMultiple Airlines
Deal found 12/10$309
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:05 amSDF - CHS
1 stop16h 18mSpirit Airlines
Fri 12/2610:18 pmCHS - SDF
1 stop25h 41mSpirit Airlines
Deal found 12/10$309
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:05 amSDF - CLT
1 stop18h 24mSpirit Airlines
Mon 12/297:00 amCLT - SDF
1 stop16h 59mSpirit Airlines
Deal found 12/10$311
This Mytrip deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:05 amSDF - CLT
1 stop15h 28mSpirit Airlines
Mon 1/59:00 amCLT - SDF
1 stop14h 59mSpirit Airlines
Deal found 12/11$313
This Kiwi.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:44 pmSDF - CHS
1 stop26h 52mBreeze Airways
Mon 12/297:05 amCHS - SDF
Nonstop1h 53mBreeze Airways
Deal found 12/12$315

Find flight deals from Louisville to South Carolina

Keep the following information in mind while searching for Louisville to South Carolina flight deals. Data was last updated December 13, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$131
(Kiwi.com)

One-way from

$80
(Kiwi.com)

Popular in

December

Cheapest in

March

Average price

$481

Good round-trip deal

$128 or less
Provider with most accurate pricing for Louisville Intl-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Louisville Intl-Myrtle Beach Intl flights.
Search Deals
From Louisville Intl to South Carolina
Search Deals
One-way flight from Louisville Intl to South Carolina
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($79 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Louisville Intl to South Carolina.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 13, 2025.
Use the filters below to find and compare flights from Louisville to South Carolina that are best for you.

Fly from

Louisville

Fly to

South Carolina

Route

Depart

Return

Price

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Fri 1/2

8:52 pm-10:28 pm

Nonstop1h 36m

Charleston

Mon 1/5

7:05 am-8:58 am

Nonstop1h 53m

$143

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Mon 1/5

8:52 pm-10:28 pm

Nonstop1h 36m

Charleston

Mon 1/12

3:21 pm-2:41 pm

2 stops23h 20m

$172

LouisvilleCharlotte

SDF - CLT

SDFCLT

Louisville Intl

Thu 1/22

3:36 pm-8:58 pm

1 stop29h 22m

Charlotte Douglas

Mon 1/26

5:24 pm-2:41 pm

1 stop21h 17m

$201

LouisvilleColumbia

SDF - CAE

SDFCAE

Louisville Intl

Tue 12/30

5:05 am-1:47 pm

1 stop8h 42m

Columbia Metropolitan

Tue 12/30

10:02 pm-11:59 pm

2 stops25h 57m

$223

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Fri 1/2

5:05 am-9:23 pm

1 stop16h 18m

Charleston

Mon 1/5

7:05 am-8:58 am

Nonstop1h 53m

$227

LouisvilleCharlotte

SDF - CLT

SDFCLT

Louisville Intl

Fri 1/9

1:55 pm-7:51 pm

1 stop5h 56m

Charlotte Douglas

Sun 1/11

7:43 pm-1:00 pm

2 stops17h 17m

$233

LouisvilleSavannah

SDF - SAV

SDFSAV

Louisville Intl

Wed 12/24

8:00 am-2:25 pm

1 stop6h 25m

Savannah/Hilton Head

Thu 1/1

4:27 pm-10:14 pm

1 stop5h 47m

$236

LouisvilleMyrtle Beach

SDF - MYR

SDFMYR

Louisville Intl

Mon 3/23

9:09 pm-5:39 pm

1 stop20h 30m

Myrtle Beach Intl

Mon 3/30

6:37 pm-2:33 pm

1 stop19h 56m

$236

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Mon 1/19

5:35 am-9:26 am

1 stop3h 51m

Charleston

Fri 1/23

3:02 pm-9:05 pm

1 stop6h 03m

$237

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Fri 1/16

6:00 am-9:19 am

1 stop3h 19m

Charleston

Sun 1/18

8:00 am-11:37 am

1 stop3h 37m

$237

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/12

Showing 1-10 of 60 results
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Best time to book a flight from Louisville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to South Carolina

What is the cheapest month to book a flight from Louisville to South Carolina?

Currently, October is the cheapest month in which you can book a flight from Louisville to South Carolina (average of $41). Flying from Louisville to South Carolina in November is currently the most expensive (average of $82). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDF to SC?

Find hourly flight availability from Louisville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 13, 2025.

A simple way to save on the total cost of your ticket is to fly from Louisville to South Carolina in the afternoon. If you’re flexible enough to do this you can expect to save up to 23% on your trip compared to booking a flight at noon.

What is the cheapest day to fly from Louisville to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Louisville to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Louisville to South Carolina flight should consider departing on Saturday at noon when fares are most often at their lowest. Friday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 13, 2025.
Get a feel of what it's like to fly with Breeze Airways, Delta, and American Airlines from Louisville to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Breeze Airways
8.2
Very good
248 reviews

Crew

8.8

Comfort

8.2

Food

6.7

Entertainment

6.7

Boarding

8.4

Overall

8.2

Reviews

1 / 16
10.0
Excellent

Anonymous,Dec 2025

RSW - ISP

There was no food offered so I had to just put okay. Other than that all was great.
Breeze Airways
8.2
Very good
248 reviews
Breeze Airways
8.2
Very good
248 reviews

Crew

8.8

Comfort

8.2

Food

6.7

Entertainment

6.7

Boarding

8.4

Overall

8.2

Reviews

1 / 16
10.0
Excellent

Anonymous,Dec 2025

RSW - ISP

There was no food offered so I had to just put okay. Other than that all was great.
Delta
7.9
Good
8,006 reviews
Breeze Airways
8.2
Very good
248 reviews

Crew

8.8

Comfort

8.2

Food

6.7

Entertainment

6.7

Boarding

8.4

Overall

8.2

Reviews

1 / 16
10.0
Excellent

Anonymous,Dec 2025

RSW - ISP

There was no food offered so I had to just put okay. Other than that all was great.
American Airlines
7.2
Good
11,056 reviews
Breeze Airways
8.2
Very good
248 reviews

Crew

8.8

Comfort

8.2

Food

6.7

Entertainment

6.7

Boarding

8.4

Overall

8.2

Reviews

1 / 16
10.0
Excellent

Anonymous,Dec 2025

RSW - ISP

There was no food offered so I had to just put okay. Other than that all was great.
Allegiant Air
7.2
Good
700 reviews
Breeze Airways
8.2
Very good
248 reviews

Crew

8.8

Comfort

8.2

Food

6.7

Entertainment

6.7

Boarding

8.4

Overall

8.2

Reviews

1 / 16
10.0
Excellent

Anonymous,Dec 2025

RSW - ISP

There was no food offered so I had to just put okay. Other than that all was great.
Spirit Airlines
6.3
Okay
8,183 reviews
Breeze Airways
8.2
Very good
248 reviews

Crew

8.8

Comfort

8.2

Food

6.7

Entertainment

6.7

Boarding

8.4

Overall

8.2

Reviews

1 / 16
10.0
Excellent

Anonymous,Dec 2025

RSW - ISP

There was no food offered so I had to just put okay. Other than that all was great.

Related info for your journey

Find useful and relevant information for your journey from Louisville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Louisville to South Carolina?

    Most people fly from Louisville Intl (SDF) if they book a flight from Louisville to South Carolina. Louisville Intl is conveniently located just 5.3 mi from Louisville’s city center.

  • How popular is this Louisville to South Carolina flight route?

    The Louisville Intl to South Carolina flight path was viewed by 5 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Louisville to South Carolina?

    A quick flight from Louisville to South Carolina can take about 1h 36m. Breeze Airways provides one of the quickest options available for as low as $143. The distance from Louisville to South Carolina is about 485 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Louisville to South Carolina one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $137. Users have also found prices from $138 and $254 on Aeromexico and United Airlines, respectively.

  • What are the most popular routes from Louisville to South Carolina?

    The most popular flight routes from Louisville to South Carolina are Louisville Intl - Charlotte Douglas, Louisville Intl - Charleston and Louisville Intl - Savannah/Hilton Head.

  • What are the cheapest flights from Louisville to South Carolina?

    Looking for the cheapest flight from Louisville to South Carolina? While on average our users pay $213, our data indicates the cheapest price to be $88. The most popular route (Louisville Intl - Charlotte Douglas), is priced around $178.

  • Can I find deals for flights from Louisville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Louisville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to South Carolina.

  • Can I find deals for business class flights from Louisville to South Carolina?

    Yes. Cheapflights offers flight deals from Louisville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Louisville to South Carolina (average of $41). Flying from Louisville to South Carolina in November is currently the most expensive (average of $82). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Louisville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from Louisville to South Carolina

Discover the top 7 airlines that operate flights from Louisville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$77Average$137FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$86Average$177FlexibilityNo cancel feeOn-time65%
Breeze AirwaysCheapest$88Average$127FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$137Average$305FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$148Average$430FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$190Average$321FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$219Average$349FlexibilityNo cancel feeOn-time63%

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