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South Carolina

$92+ Cheap flights from Louisville (SDF) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/9. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — CHS
Feb 11 — Feb 181
Wed 2/11
Wed 2/18
1 adult, Economy
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Cheap flight deals from Louisville to South Carolina

Keep the following information in mind while searching for Louisville to South Carolina flight deals. Data was last updated January 12, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$123
(Kiwi.com)

One-way from

$92
(Kiwi.com)

Popular in

January

Cheapest in

March

Average price

$500

Good round-trip deal

$114 or less
Provider with most accurate pricing for Louisville Intl-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Louisville Intl-Myrtle Beach Intl flights.
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From Louisville Intl to South Carolina
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One-way flight from Louisville Intl to South Carolina
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Highest demand for flights based on searches. 33% potential increase in price ($144 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Price to beat on a round-trip flight from Louisville Intl to South Carolina.
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Find flight deals from Louisville to South Carolina

Cheapest flights from Louisville to South Carolina
Explore the most affordable flight options available from Louisville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 12, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/128:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Mon 6/157:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 1/11$123
This Kiwi.com deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Mon 5/187:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 1/11$137
This Breeze Airways deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Mon 5/117:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 1/10$144
This Kiwi.com deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/201:06 pm
SDF
-
MYR
Nonstop1h 32m
Allegiant Air
Sat 6/2710:39 am
MYR
-
SDF
Nonstop1h 37m
Allegiant Air
Deal found 1/11$151
This Kiwi.com deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/271:06 pm
SDF
-
MYR
Nonstop1h 32m
Allegiant Air
Sat 7/410:37 am
MYR
-
SDF
Nonstop1h 35m
Allegiant Air
Deal found 1/11$157
This Kiwi.com deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/131:06 pm
SDF
-
MYR
Nonstop1h 32m
Allegiant Air
Sat 6/2010:39 am
MYR
-
SDF
Nonstop1h 37m
Allegiant Air
Deal found 1/11$162
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/48:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Mon 9/77:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 1/12$167
This Breeze Airways deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Mon 7/207:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 1/11$168
This Kiwi.com deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/271:19 pm
SDF
-
CLT
1 stop27h 35m
Spirit Airlines
Tue 3/35:49 pm
CLT
-
SDF
1 stop18h 32m
Spirit Airlines
Deal found 1/11$179
This Kiwi.com deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/251:19 pm
SDF
-
CLT
1 stop18h 39m
Multiple Airlines
Tue 3/35:49 pm
CLT
-
SDF
1 stop18h 32m
Multiple Airlines
Deal found 1/11$190
This Kiwi.com deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/243:33 pm
SDF
-
CLT
1 stop8h 23m
Spirit Airlines
Tue 3/35:49 pm
CLT
-
SDF
1 stop18h 32m
Spirit Airlines
Deal found 1/11$195
This Kiwi.com deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/251:19 pm
SDF
-
CLT
1 stop18h 39m
Multiple Airlines
Thu 2/267:13 pm
CLT
-
SDF
1 stop13h 27m
Multiple Airlines
Deal found 1/11$197

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 12, 2026.
Use the filters below to find and compare flights from Louisville to South Carolina that are best for you.

Fly from

Louisville

Fly to

South Carolina

Route

Depart

Return

Price

LouisvilleCharlotte

SDF - CLT

SDFCLT

Louisville Intl

Mon 3/2

1:19 pm-10:17 am

1 stop20h 58m

Charlotte Douglas

Tue 3/3

5:49 pm-12:21 pm

1 stop18h 32m

$179

LouisvilleCharlotte

SDF - CLT

SDFCLT

Louisville Intl

Fri 2/27

1:19 pm-4:54 pm

1 stop27h 35m

Charlotte Douglas

Tue 3/3

5:49 pm-12:21 pm

1 stop18h 32m

$179

LouisvilleCharlotte

SDF - CLT

SDFCLT

Louisville Intl

Wed 2/25

1:19 pm-11:56 pm

2 stops10h 37m

Charlotte Douglas

Tue 3/3

5:49 pm-12:21 pm

1 stop18h 32m

$200

LouisvilleCharlotte

SDF - CLT

SDFCLT

Louisville Intl

Thu 2/26

3:33 pm-11:56 pm

1 stop8h 23m

Charlotte Douglas

Sun 3/1

9:52 pm-12:21 pm

1 stop14h 29m

$219

LouisvilleCharlotte

SDF - CLT

SDFCLT

Louisville Intl

Mon 3/2

9:30 am-6:18 pm

1 stop8h 48m

Charlotte Douglas

Wed 3/4

5:49 pm-8:40 am

2 stops38h 51m

$225

LouisvilleMyrtle Beach

SDF - MYR

SDFMYR

Louisville Intl

Tue 2/10

3:36 pm-9:03 am

2 stops17h 27m

Myrtle Beach Intl

Tue 2/24

9:09 am-2:38 pm

1 stop5h 29m

$225

LouisvilleSavannah

SDF - SAV

SDFSAV

Louisville Intl

Mon 2/16

9:30 am-6:17 pm

1 stop8h 47m

Savannah/Hilton Head

Fri 2/20

2:03 pm-11:05 am

1 stop21h 02m

$226

LouisvilleCharlotte

SDF - CLT

SDFCLT

Louisville Intl

Tue 2/3

3:36 pm-4:54 pm

2 stops25h 18m

Charlotte Douglas

Fri 2/6

6:00 am-6:04 pm

1 stop12h 04m

$227

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Sun 2/8

3:36 pm-5:39 pm

1 stop26h 03m

Charleston

Sun 2/15

6:15 am-1:26 pm

2 stops7h 11m

$228

LouisvilleCharlotte

SDF - CLT

SDFCLT

Louisville Intl

Mon 2/9

1:55 pm-4:54 pm

1 stop26h 59m

Charlotte Douglas

Mon 2/16

7:29 pm-2:38 pm

2 stops19h 09m

$230

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/11

Showing 1-10 of 60 results
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Best time to book a flight from Louisville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to South Carolina

What is the cheapest month to book a flight from Louisville to South Carolina?

Currently, October is the cheapest month in which you can book a flight from Louisville to South Carolina (average of $41). Flying from Louisville to South Carolina in November is currently the most expensive (average of $82). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDF to SC?

Find hourly flight availability from Louisville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 12, 2026.

A simple way to save on the total cost of your ticket is to fly from Louisville to South Carolina in the afternoon. If you’re flexible enough to do this you can expect to save up to 47% on your trip compared to booking a flight at noon.

What is the cheapest day to fly from Louisville to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Louisville to South Carolina. Price data was last updated on January 10, 2026.

Travelers seeking maximum savings on their Louisville to South Carolina flight should consider departing on Saturday at noon when fares are most often at their lowest. Friday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 12, 2026.
Get a feel of what it's like to fly with Breeze Airways, Delta, and American Airlines from Louisville to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Breeze Airways
8.1
Very good
258 reviews

Entertainment

6.7

Comfort

8.2

Boarding

8.3

Crew

8.7

Overall

8.1

Food

6.7

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Breeze Airways
8.1
Very good
258 reviews
Breeze Airways
8.1
Very good
258 reviews

Entertainment

6.7

Comfort

8.2

Boarding

8.3

Crew

8.7

Overall

8.1

Food

6.7

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Delta
7.9
Good
8,039 reviews
Breeze Airways
8.1
Very good
258 reviews

Entertainment

6.7

Comfort

8.2

Boarding

8.3

Crew

8.7

Overall

8.1

Food

6.7

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
American Airlines
7.2
Good
11,114 reviews
Breeze Airways
8.1
Very good
258 reviews

Entertainment

6.7

Comfort

8.2

Boarding

8.3

Crew

8.7

Overall

8.1

Food

6.7

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Allegiant Air
7.2
Good
702 reviews
Breeze Airways
8.1
Very good
258 reviews

Entertainment

6.7

Comfort

8.2

Boarding

8.3

Crew

8.7

Overall

8.1

Food

6.7

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Spirit Airlines
6.3
Okay
8,303 reviews
Breeze Airways
8.1
Very good
258 reviews

Entertainment

6.7

Comfort

8.2

Boarding

8.3

Crew

8.7

Overall

8.1

Food

6.7

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.

Related info for your journey

Find useful and relevant information for your journey from Louisville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Louisville to South Carolina?

    Most people fly from Louisville Intl (SDF) if they book a flight from Louisville to South Carolina. Louisville Intl is conveniently located just 5.3 mi from Louisville’s city center.

  • How popular is this Louisville to South Carolina flight route?

    The Louisville Intl to South Carolina flight path was viewed by 5 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Louisville to South Carolina?

    A quick flight from Louisville to South Carolina can take about 3h 51m. Spirit Airlines provides one of the quickest options available for as low as $257. The distance from Louisville to South Carolina is about 485 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Louisville to South Carolina one-way?

    For one-way options, check prices for Spirit Airlines. According to our data, you can fly for as low as $37. Users have also found prices from $49 and $108 on Breeze Airways and Delta, respectively.

  • What are the most popular routes from Louisville to South Carolina?

    The most popular flight routes from Louisville to South Carolina are Louisville Intl - Charleston, Louisville Intl - Charlotte Douglas and Louisville Intl - Savannah/Hilton Head.

  • What are the cheapest flights from Louisville to South Carolina?

    Looking for the cheapest flight from Louisville to South Carolina? While on average our users pay $147, our data indicates the cheapest price to be $114. The most popular route (Louisville Intl - Charleston), is priced around $123.

  • Can I find deals for flights from Louisville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Louisville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to South Carolina.

  • Can I find deals for business class flights from Louisville to South Carolina?

    Yes. Cheapflights offers flight deals from Louisville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Louisville to South Carolina (average of $41). Flying from Louisville to South Carolina in November is currently the most expensive (average of $82). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Louisville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Louisville to South Carolina

Discover the top 6 airlines that operate flights from Louisville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$77Average$130FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$86Average$176FlexibilityNo cancel feeOn-time65%
Breeze AirwaysCheapest$88Average$127FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$137Average$309FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$190Average$319FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$219Average$338FlexibilityNo cancel feeOn-time63%

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