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South Carolina

$61+ Cheap flights from Louisville (SDF) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — CHS
Mar 4 — Mar 111
Wed 3/4
Wed 3/11
1 adult, Economy
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Cheap flight deals from Louisville to South Carolina

Cheapest flights from Louisville to South Carolina
Explore the most affordable flight options available from Louisville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 2, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/78:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Fri 9/117:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 1/31$102
This Mytrip deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Mon 5/117:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 1/30$132
This Mytrip deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Fri 5/157:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 1/31$135
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Mon 7/277:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 2/2$137
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Mon 5/187:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 2/1$142
This Mytrip deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Fri 5/153:54 pm
CHS
-
SDF
1 stop4h 54m
Breeze Airways
Deal found 1/31$148
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Thu 5/2110:58 am
CHS
-
SDF
1 stop7h 17m
Breeze Airways
Deal found 2/1$152
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/41:02 pm
SDF
-
MYR
Nonstop1h 30m
Allegiant Air
Sat 7/1110:37 am
MYR
-
SDF
Nonstop1h 35m
Allegiant Air
Deal found 1/31$155
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/169:13 pm
SDF
-
CLT
1 stop17h 04m
Multiple Airlines
Mon 3/239:06 am
CLT
-
SDF
1 stop26h 41m
Multiple Airlines
Deal found 2/1$194
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/181:02 pm
SDF
-
MYR
Nonstop1h 30m
Allegiant Air
Sat 7/2510:37 am
MYR
-
SDF
Nonstop1h 35m
Allegiant Air
Deal found 2/1$195
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/13:33 pm
SDF
-
CLT
1 stop16h 53m
Multiple Airlines
Sun 3/87:48 pm
CLT
-
SDF
1 stop16h 33m
Multiple Airlines
Deal found 1/30$216
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/61:19 pm
SDF
-
CLT
1 stop19h 41m
Multiple Airlines
Sun 3/87:48 pm
CLT
-
SDF
1 stop16h 33m
Multiple Airlines
Deal found 2/1$219

Find flight deals from Louisville to South Carolina

Keep the following information in mind while searching for Louisville to South Carolina flight deals. Data was last updated February 2, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$132
(Mytrip)

One-way from

$61
(Mytrip)

Popular in

January

Cheapest in

March

Average price

$376

Good round-trip deal

$138 or less
Provider with most accurate pricing for Louisville Intl-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Louisville Intl-Myrtle Beach Intl flights.
Search Deals
From Louisville Intl to South Carolina
Search Deals
One-way flight from Louisville Intl to South Carolina
Search Deals
Highest demand for flights based on searches. 33% potential increase in price ($141 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a round-trip flight from Louisville Intl to South Carolina.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 2, 2026.
Use the filters below to find and compare flights from Louisville to South Carolina that are best for you.

Fly from

Louisville

Fly to

South Carolina

Route

Depart

Return

Price

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Fri 5/15

8:28 pm-10:06 pm

Nonstop1h 38m

Charleston

Mon 5/18

7:00 am-8:46 am

Nonstop1h 46m

$144

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Fri 5/8

8:28 pm-10:06 pm

Nonstop1h 38m

Charleston

Mon 5/11

3:54 pm-8:48 pm

1 stop4h 54m

$170

LouisvilleCharlotte

SDF - CLT

SDFCLT

Louisville Intl

Mon 3/16

9:13 pm-2:17 pm

1 stop17h 04m

Charlotte Douglas

Mon 3/23

9:06 am-11:47 am

1 stop26h 41m

$194

LouisvilleCharlotte

SDF - CLT

SDFCLT

Louisville Intl

Fri 3/6

1:19 pm-9:00 am

1 stop19h 41m

Charlotte Douglas

Sun 3/8

7:48 pm-12:21 pm

1 stop16h 33m

$219

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Mon 3/2

5:33 am-11:56 am

1 stop6h 23m

Charleston

Fri 3/6

5:27 am-9:28 am

1 stop4h 01m

$237

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Fri 2/27

7:51 pm-11:54 pm

1 stop4h 03m

Charleston

Mon 3/2

7:00 pm-10:47 pm

1 stop3h 47m

$239

LouisvilleColumbia

SDF - CAE

SDFCAE

Louisville Intl

Thu 3/5

5:00 am-8:39 am

1 stop3h 39m

Columbia Metropolitan

Thu 3/12

7:00 am-3:03 pm

1 stop8h 03m

$249

LouisvilleColumbia

SDF - CAE

SDFCAE

Louisville Intl

Wed 5/20

6:00 am-11:08 am

1 stop5h 08m

Columbia Metropolitan

Sat 5/23

5:50 pm-11:59 pm

1 stop6h 09m

$249

LouisvilleMyrtle Beach

SDF - MYR

SDFMYR

Louisville Intl

Fri 3/6

1:19 pm-10:59 am

1 stop21h 40m

Myrtle Beach Intl

Tue 3/10

12:39 pm-12:21 pm

1 stop23h 42m

$251

LouisvilleMyrtle Beach

SDF - MYR

SDFMYR

Louisville Intl

Mon 3/9

9:30 am-8:13 am

1 stop22h 43m

Myrtle Beach Intl

Wed 3/11

9:54 pm-2:33 pm

2 stops16h 39m

$255

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/1

Showing 1-10 of 60 results
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Best time to book a flight from Louisville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to South Carolina

What is the cheapest month to book a flight from Louisville to South Carolina?

Currently, October is the cheapest month in which you can book a flight from Louisville to South Carolina (average of $41). Flying from Louisville to South Carolina in November is currently the most expensive (average of $82). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDF to SC?

Find hourly flight availability from Louisville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 2, 2026.

A simple way to save on the total cost of your ticket is to fly from Louisville to South Carolina in the afternoon. If you’re flexible enough to do this you can expect to save up to 48% on your trip compared to booking a flight at noon.

What is the cheapest day to fly from Louisville to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Louisville to South Carolina. Price data was last updated on January 31, 2026.

Travelers seeking maximum savings on their Louisville to South Carolina flight should consider departing on Saturday at noon when fares are most often at their lowest. Friday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 2, 2026.
Get a feel of what it's like to fly with Breeze Airways, Delta, and American Airlines from Louisville to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Breeze Airways
8.2
Very good
263 reviews

Comfort

8.2

Entertainment

6.6

Crew

8.7

Food

6.7

Overall

8.2

Boarding

8.3

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Breeze Airways
8.2
Very good
263 reviews
Breeze Airways
8.2
Very good
263 reviews

Comfort

8.2

Entertainment

6.6

Crew

8.7

Food

6.7

Overall

8.2

Boarding

8.3

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Delta
7.9
Good
8,135 reviews
Breeze Airways
8.2
Very good
263 reviews

Comfort

8.2

Entertainment

6.6

Crew

8.7

Food

6.7

Overall

8.2

Boarding

8.3

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
American Airlines
7.2
Good
11,212 reviews
Breeze Airways
8.2
Very good
263 reviews

Comfort

8.2

Entertainment

6.6

Crew

8.7

Food

6.7

Overall

8.2

Boarding

8.3

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Allegiant Air
7.2
Good
708 reviews
Breeze Airways
8.2
Very good
263 reviews

Comfort

8.2

Entertainment

6.6

Crew

8.7

Food

6.7

Overall

8.2

Boarding

8.3

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Spirit Airlines
6.3
Okay
8,399 reviews
Breeze Airways
8.2
Very good
263 reviews

Comfort

8.2

Entertainment

6.6

Crew

8.7

Food

6.7

Overall

8.2

Boarding

8.3

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.

Related info for your journey

Find useful and relevant information for your journey from Louisville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Louisville to South Carolina?

    Most people fly from Louisville Intl (SDF) if they book a flight from Louisville to South Carolina. Louisville Intl is conveniently located just 5.3 mi from Louisville’s city center.

  • How popular is this Louisville to South Carolina flight route?

    The Louisville Intl to South Carolina flight path was viewed by 5 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Louisville to South Carolina?

    A quick flight from Louisville to South Carolina can take about 1h 38m. Breeze Airways provides one of the quickest options available for as low as $144. The distance from Louisville to South Carolina is about 485 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Louisville to South Carolina one-way?

    For one-way options, check prices for Spirit Airlines. According to our data, you can fly for as low as $37. Users have also found prices from $49 and $108 on Breeze Airways and Delta, respectively.

  • What are the most popular routes from Louisville to South Carolina?

    The most popular flight routes from Louisville to South Carolina are Louisville Intl - Charleston, Louisville Intl - Savannah/Hilton Head and Louisville Intl - Charlotte Douglas.

  • What are the cheapest flights from Louisville to South Carolina?

    Looking for the cheapest flight from Louisville to South Carolina? While on average our users pay $161, our data indicates the cheapest price to be $138. The most popular route (Louisville Intl - Charleston), is priced around $132.

  • Can I find deals for flights from Louisville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Louisville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to South Carolina.

  • Can I find deals for business class flights from Louisville to South Carolina?

    Yes. Cheapflights offers flight deals from Louisville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Louisville to South Carolina (average of $41). Flying from Louisville to South Carolina in November is currently the most expensive (average of $82). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Louisville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from Louisville to South Carolina

Discover the top 7 airlines that operate flights from Louisville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 2, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$60Average$132FlexibilityNo cancel feeOn-time88%
Breeze AirwaysCheapest$71Average$127FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$84Average$171FlexibilityNo cancel feeOn-time65%
DeltaCheapest$121Average$306FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$148Average$468FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$190Average$314FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$219Average$338FlexibilityNo cancel feeOn-time63%

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