$58+ Cheap flights from Louisville (SDF) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — CHS
Oct 23 — Oct 301
Round-trip
1 adult, Economy
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Find cheap flights from Louisville to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Louisville to South Carolina
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Cheapest flights from Louisville to South CarolinaExplore the most affordable flight options available from Louisville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
Explore the most affordable flight options available from Louisville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:59 pm -
Nonstop1h 35m
Mon 12/76:10 am -
Nonstop1h 52m
Deal found 9/19![Breeze Airways logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:59 pm -
Nonstop1h 35m
Mon 11/26:10 am -
Nonstop1h 52m
Deal found 9/23![Breeze Airways logo]()
$113
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:59 pm -
Nonstop1h 35m
Fri 11/136:10 am -
Nonstop1h 52m
Deal found 9/22![Breeze Airways logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:59 pm -
Nonstop1h 35m
Fri 11/206:10 am -
Nonstop1h 52m
Deal found 9/21![Breeze Airways logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:59 pm -
Nonstop1h 35m
Fri 11/66:10 am -
Nonstop1h 52m
Deal found 9/18![Breeze Airways logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:59 pm -
Nonstop1h 35m
Fri 10/236:10 am -
Nonstop1h 52m
Deal found 9/23![Breeze Airways logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:59 pm -
Nonstop1h 35m
Fri 10/236:10 am -
Nonstop1h 52m
Deal found 9/19![Breeze Airways logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:59 pm -
Nonstop1h 35m
Fri 10/236:10 am -
Nonstop1h 52m
Deal found 9/19![Breeze Airways logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:59 pm -
Nonstop1h 35m
Mon 10/266:10 am -
Nonstop1h 52m
Deal found 9/19![Breeze Airways logo]()
$142
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/161:04 pm -
1 stop4h 59m
Wed 12/3012:10 pm -
1 stop6h 01m
Deal found 9/19![Delta logo]()
$279
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:29 am -
1 stop4h 39m
Mon 10/198:33 pm -
1 stop3h 35m
Deal found 9/23![American Airlines logo]()
$279
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
1 stop4h 25m
Sat 10/3110:55 am -
1 stop6h 51m
Deal found 9/18![American Airlines logo]()
$291
Best flights from Louisville to South CarolinaDiscover carefully curated flight deals from Louisville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
Discover carefully curated flight deals from Louisville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:55 pm -
1 stop4h 04m
Fri 10/237:05 pm -
1 stop4h 54m
Deal found 9/18![Delta logo]()
$237
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:04 am -
1 stop3h 20m
Mon 11/24:37 pm -
1 stop5h 00m
Deal found 9/21![American Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/193:35 pm -
2 stops6h 00m
Fri 11/67:55 pm -
1 stop4h 30m
Deal found 9/18![Southwest logo]()
$307
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:00 am -
2 stops12h 08m
Sat 11/1410:16 am -
2 stops10h 18m
Deal found 9/18![United Airlines logo]()
$311
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:06 am -
1 stop4h 24m
Tue 11/312:23 pm -
2 stops8h 50m
Deal found 9/18![Delta logo]()
$296
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:01 am -
1 stop4h 12m
Sat 11/146:20 am -
1 stop5h 07m
Deal found 9/18![American Airlines logo]()
$301
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/193:35 pm -
2 stops6h 00m
Fri 10/238:05 pm -
1 stop4h 10m
Deal found 9/18![Southwest logo]()
$307
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:15 am -
1 stop6h 20m
Sat 10/172:51 pm -
1 stop5h 40m
Deal found 9/20![United Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/218:26 am -
1 stop6h 28m
Mon 1/44:30 pm -
1 stop4h 21m
Deal found 9/19![Delta logo]()
$318
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/179:04 am -
1 stop5h 06m
Sat 10/242:51 pm -
1 stop5h 40m
Deal found 9/20![United Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1312:05 pm -
2 stops8h 05m
Mon 12/77:05 am -
1 stop5h 10m
Deal found 9/20![Southwest logo]()
$323
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:30 pm -
1 stop5h 29m
Sat 10/1711:05 am -
2 stops8h 19m
Deal found 9/18![United Airlines logo]()
$320
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/71:59 pm -
1 stop3h 15m
Sun 10/117:19 pm -
1 stop3h 18m
Deal found 9/20![Delta logo]()
$334
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/225:40 am -
1 stop4h 20m
Tue 12/297:15 pm -
1 stop5h 10m
Deal found 9/19![Southwest logo]()
$343
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:24 am -
2 stops7h 54m
Wed 11/255:47 pm -
1 stop5h 27m
Deal found 9/22![American Airlines logo]()
$381
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
1 stop4h 07m
Fri 10/236:58 pm -
1 stop5h 01m
Deal found 9/21![Delta logo]()
$347
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/39:04 am -
1 stop5h 06m
Wed 10/71:20 pm -
1 stop6h 53m
Deal found 9/19![United Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:35 am -
2 stops10h 30m
Mon 10/198:05 pm -
1 stop4h 10m
Deal found 9/20![Southwest logo]()
$374
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:05 am -
1 stop6h 28m
Thu 12/3110:46 am -
1 stop5h 07m
Deal found 9/19![Delta logo]()
$357
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:35 pm -
1 stop5h 25m
Sun 11/156:40 am -
1 stop5h 30m
Deal found 9/21![Southwest logo]()
$376
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:00 am -
1 stop3h 44m
Wed 10/2110:38 am -
2 stops8h 46m
Deal found 9/21![United Airlines logo]()
$392
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:55 am -
2 stops7h 35m
Sat 10/3112:23 pm -
1 stop4h 31m
Deal found 9/18![Delta logo]()
$366
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/222:10 pm -
2 stops7h 45m
Fri 1/16:35 am -
2 stops8h 40m
Deal found 9/21![Southwest logo]()
$393
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1010:37 am -
2 stops12h 23m
Wed 11/115:40 am -
2 stops12h 52m
Deal found 9/19![United Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:04 am -
1 stop3h 23m
Sun 10/258:30 pm -
1 stop3h 38m
Deal found 9/18![American Airlines logo]()
$534
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/248:05 am -
1 stop3h 47m
Fri 11/277:05 am -
1 stop3h 27m
Deal found 9/19![Delta logo]()
$379
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:45 am -
2 stops10h 30m
Wed 10/146:40 pm -
1 stop4h 25m
Deal found 9/22![Southwest logo]()
$422
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:55 am -
2 stops7h 35m
Wed 10/2812:23 pm -
2 stops8h 50m
Deal found 9/18![Delta logo]()
$405
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/167:10 am -
2 stops10h 24m
Thu 12/316:10 pm -
1 stop5h 34m
Deal found 9/19![United Airlines logo]()
$447
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:20 am -
2 stops13h 10m
Mon 10/196:15 am -
2 stops10h 45m
Deal found 9/18![Southwest logo]()
$428
Last-minute flights from Louisville to South CarolinaDiscover last-minute flight deals from Louisville to South Carolina. Data last updated September 23, 2026 and is based on user searches.
Discover last-minute flight deals from Louisville to South Carolina. Data last updated September 23, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:59 pm -
Nonstop1h 35m
Fri 10/236:10 am -
Nonstop1h 52m
Deal found 9/23![Breeze Airways logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:59 pm -
Nonstop1h 35m
Mon 10/126:10 am -
Nonstop1h 52m
Deal found 9/19![Breeze Airways logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:59 pm -
Nonstop1h 35m
Fri 10/236:10 am -
Nonstop1h 52m
Deal found 9/19![Breeze Airways logo]()
$137
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 pm -
1 stop4h 02m
Mon 10/198:12 pm -
1 stop3h 56m
Deal found 9/18![American Airlines logo]()
$297
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:29 am -
1 stop4h 39m
Mon 10/198:33 pm -
1 stop3h 35m
Deal found 9/23![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:59 pm -
Nonstop1h 35m
Fri 11/66:10 am -
Nonstop1h 52m
Deal found 9/18![Breeze Airways logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:59 pm -
Nonstop1h 35m
Fri 10/236:10 am -
Nonstop1h 52m
Deal found 9/19![Breeze Airways logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:59 pm -
Nonstop1h 35m
Mon 10/266:10 am -
Nonstop1h 52m
Deal found 9/19![Breeze Airways logo]()
$142
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
1 stop4h 25m
Sat 10/3110:55 am -
1 stop6h 51m
Deal found 9/18![American Airlines logo]()
$291
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:06 am -
1 stop4h 24m
Tue 11/312:23 pm -
2 stops8h 50m
Deal found 9/18![Delta logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:59 pm -
Nonstop1h 35m
Mon 11/26:10 am -
Nonstop1h 52m
Deal found 9/23![Breeze Airways logo]()
$113
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:35 pm -
1 stop5h 25m
Wed 11/44:37 pm -
1 stop4h 59m
Deal found 9/20![American Airlines logo]()
$300
One-way flights from Louisville to South CarolinaSearch for one-way flight options from Louisville to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 23, 2026.
Search for one-way flight options from Louisville to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:59 pm -
Nonstop1h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Breeze Airways logo]()
$58
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:59 pm -
Nonstop1h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Breeze Airways logo]()
$63
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:59 pm -
Nonstop1h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Breeze Airways logo]()
$68
This Breeze Airways deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:59 pm -
Nonstop1h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Breeze Airways logo]()
$74
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:59 pm -
Nonstop1h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Breeze Airways logo]()
$113
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:19 pm -
1 stop6h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![American Airlines logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:25 am -
1 stop10h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Breeze Airways logo]()
$129
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop4h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Delta logo]()
$140
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/103:50 pm -
1 stop4h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Southwest logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/159:09 pm -
1 stop14h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Breeze Airways logo]()
$149
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop3h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![United Airlines logo]()
$158
This Southwest deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:45 am -
2 stops7h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Southwest logo]()
$174
Find flight deals from Louisville to South Carolina
Keep the following information in mind while searching for Louisville to South Carolina flight deals. Data was last updated September 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $107 (Kiwi.com) |
One-way from | $58 (Kiwi.com) |
Popular in | April |
Cheapest in | July |
Average price | $300 |
Good round-trip deal | $143 or less |
Good one-way deal | $61 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Louisville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
Use the filters below to find and compare flights from Louisville to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Mon 10/19
5:57 pm-11:59 pm
1 stop6h 02m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$119
LouisvilleGreenville
SDF Louisville Intl - GSP Greenville
SDFGSP
Louisville Intl
Thu 12/10
3:50 pm-8:45 pm
1 stop4h 55m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$140
LouisvilleMyrtle Beach
SDF Louisville Intl - MYR Myrtle Beach Intl
SDFMYR
Louisville Intl
Wed 10/21
6:00 am-10:07 am
1 stop4h 07m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$140
LouisvilleMyrtle Beach
SDF Louisville Intl - MYR Myrtle Beach Intl
SDFMYR
Louisville Intl
Wed 10/21
6:00 am-9:44 am
1 stop3h 44m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$158
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Sat 11/7
11:57 am-4:58 pm
1 stop5h 01m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$158
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Tue 10/20
1:25 pm-6:48 pm
1 stop5h 23m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$158
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Wed 10/21
6:00 am-10:10 am
1 stop4h 10m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$158
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Sat 10/17
6:15 am-1:55 pm
1 stop7h 40m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$158
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Sat 10/24
5:59 pm-11:59 pm
1 stop6h 00m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$158
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Tue 10/13
7:05 am-1:00 pm
1 stop5h 55m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$158
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Louisville to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Louisville with our price prediction graph.
SDF-CHS
SDF-GSP
SDF-CAE
SDF-HHH
SDF-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Louisville to South Carolina
SDF-USSC
SDF-CHS
SDF-GSP
SDF-CAE
SDF-HHH
What is the cheapest month to book a flight from Louisville to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Louisville to South Carolina (average of $230). Flying from Louisville to South Carolina in September is currently the most expensive (average of $423). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SDF to SC?
Find hourly flight availability from Louisville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 23, 2026.
A simple way to save on the total cost of your ticket is to fly from Louisville to South Carolina in the morning. If you’re flexible enough to do this you can expect to save up to 70% on your trip compared to booking a flight at noon.
How much does it cost to fly round-trip from Louisville to South Carolina?
Airfare is below average for this route at the moment.
Louisville to South Carolina flights typically cost between $170 and $380 in November.The cheapest round-trip price found within the last 5 days was $107 on Breeze Airways (Nov 13-Dec 7).
How far ahead should I book a flight from Louisville to South Carolina?
To ensure you get the cheapest price possible for a flight from Louisville to South Carolina, you should look to book at least 57 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 23, 2026.
Get a feel of what it's like to fly with Breeze Airways,Southwest, andDelta from Louisville to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.8
Boarding
8.4
Comfort
8.2
Overall
8.2
Entertainment
6.7
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Food
6.8
Boarding
8.4
Comfort
8.2
Overall
8.2
Entertainment
6.7
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Food
6.8
Boarding
8.4
Comfort
8.2
Overall
8.2
Entertainment
6.7
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Food
6.8
Boarding
8.4
Comfort
8.2
Overall
8.2
Entertainment
6.7
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Food
6.8
Boarding
8.4
Comfort
8.2
Overall
8.2
Entertainment
6.7
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Food
6.8
Boarding
8.4
Comfort
8.2
Overall
8.2
Entertainment
6.7
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Related info for your journey
Find useful and relevant information for your journey from Louisville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Louisville to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Louisville to South Carolina by cabin class
Find flights from Louisville to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Louisville and South Carolina flights
Browse other Louisville and South Carolina flight options. Last updated on September 23, 2026.
Popular flight searches
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Louisville to South Carolina flights
Consider these flights traveling from Louisville to South Carolina.
Top 6 airlines flying from Louisville to South Carolina
Discover the top 6 airlines that operate flights from Louisville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$63 | Average$134 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$88 | Average$154 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$226 | Average$402 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$234 | Average$387 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$386 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$295 | Average$343 | FlexibilityNo cancel fee | On-time69% |