$49+ Cheap flights from Louisville (SDF) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — CHS
Sep 22 — Sep 291
Round-trip
1 adult, Economy
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Find cheap flights from Louisville to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Louisville to South Carolina
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Cheapest flights from Louisville to South CarolinaExplore the most affordable flight options available from Louisville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 23, 2026.
Explore the most affordable flight options available from Louisville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:59 pm -
Nonstop1h 35m
Mon 11/26:10 am -
Nonstop1h 52m
Deal found 8/18![Breeze Airways logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:59 pm -
Nonstop1h 35m
Mon 11/26:10 am -
Nonstop1h 52m
Deal found 8/21![Breeze Airways logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:59 pm -
Nonstop1h 35m
Mon 11/96:10 am -
Nonstop1h 52m
Deal found 8/18![Breeze Airways logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:59 pm -
Nonstop1h 35m
Mon 12/76:10 am -
Nonstop1h 52m
Deal found 8/20![Breeze Airways logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:59 pm -
Nonstop1h 35m
Mon 9/146:10 am -
Nonstop1h 52m
Deal found 8/17![Breeze Airways logo]()
$113
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:59 pm -
Nonstop1h 35m
Mon 9/216:10 am -
Nonstop1h 52m
Deal found 8/18![Breeze Airways logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:59 pm -
Nonstop1h 35m
Mon 10/126:10 am -
Nonstop1h 52m
Deal found 8/19![Breeze Airways logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:59 pm -
Nonstop1h 35m
Fri 10/306:10 am -
Nonstop1h 52m
Deal found 8/21![Breeze Airways logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:59 pm -
Nonstop1h 35m
Mon 9/216:10 am -
Nonstop1h 52m
Deal found 8/22![Breeze Airways logo]()
$137
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:16 pm -
1 stop12h 11m
Sun 10/189:35 am -
Nonstop1h 42m
Deal found 8/20![American Airlines logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:25 am -
1 stop10h 57m
Thu 10/88:57 pm -
1 stop12h 48m
Deal found 8/20![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:09 pm -
1 stop14h 35m
Thu 10/88:57 pm -
1 stop12h 48m
Deal found 8/20![Multiple Airlines logo]()
$251
Best flights from Louisville to South CarolinaDiscover carefully curated flight deals from Louisville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 23, 2026.
Discover carefully curated flight deals from Louisville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 23, 2026.
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:57 pm -
1 stop6h 02m
Fri 10/164:20 pm -
1 stop6h 17m
Deal found 8/18![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:45 am -
2 stops10h 35m
Thu 9/101:15 pm -
2 stops8h 45m
Deal found 8/18![Southwest logo]()
$267
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:15 am -
1 stop6h 20m
Sat 10/242:51 pm -
1 stop5h 40m
Deal found 8/21![United Airlines logo]()
$271
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:00 am -
1 stop4h 37m
Tue 9/292:15 pm -
1 stop4h 55m
Deal found 8/22![American Airlines logo]()
$271
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
1 stop4h 07m
Tue 10/272:16 pm -
1 stop4h 54m
Deal found 8/21![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/221:56 pm -
1 stop5h 09m
Wed 9/237:47 pm -
1 stop4h 12m
Deal found 8/20![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:35 pm -
1 stop4h 15m
Wed 10/216:50 am -
2 stops8h 25m
Deal found 8/19![Southwest logo]()
$284
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:09 am -
1 stop7h 14m
Thu 11/1211:04 am -
1 stop6h 21m
Deal found 8/19![American Airlines logo]()
$285
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:15 pm -
1 stop7h 09m
Mon 11/211:19 am -
1 stop6h 18m
Deal found 8/21![United Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:05 am -
1 stop4h 03m
Sat 11/216:04 pm -
1 stop5h 09m
Deal found 8/22![Delta logo]()
$281
This Southwest deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:10 pm -
1 stop4h 30m
Mon 11/167:05 am -
1 stop5h 10m
Deal found 8/22![Southwest logo]()
$291
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:50 pm -
1 stop7h 10m
Sat 9/1212:34 pm -
1 stop7h 58m
Deal found 8/22![United Airlines logo]()
$283
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:57 pm -
1 stop5h 50m
Sun 11/87:19 pm -
1 stop4h 40m
Deal found 8/20![Delta logo]()
$290
This Southwest deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:50 am -
2 stops7h 05m
Sat 11/76:40 am -
2 stops9h 20m
Deal found 8/21![Southwest logo]()
$299
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop3h 44m
Sat 10/2410:23 am -
2 stops8h 48m
Deal found 8/22![United Airlines logo]()
$284
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:00 am -
1 stop4h 37m
Tue 9/292:15 pm -
1 stop4h 55m
Deal found 8/19![American Airlines logo]()
$345
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/148:05 am -
1 stop3h 30m
Mon 10/195:30 am -
1 stop3h 27m
Deal found 8/18![Delta logo]()
$295
This Southwest deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:35 am -
2 stops10h 50m
Sat 10/2411:40 am -
2 stops8h 15m
Deal found 8/22![Southwest logo]()
$305
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:00 am -
2 stops7h 45m
Sat 11/79:50 am -
1 stop4h 57m
Deal found 8/21![United Airlines logo]()
$284
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:29 am -
1 stop6h 51m
Sat 10/3111:36 am -
2 stops8h 52m
Deal found 8/20![American Airlines logo]()
$361
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:09 am -
1 stop5h 05m
Sun 9/273:53 pm -
1 stop4h 40m
Deal found 8/22![Delta logo]()
$299
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:45 am -
2 stops10h 40m
Sat 11/147:30 am -
2 stops8h 55m
Deal found 8/18![Southwest logo]()
$306
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:00 am -
2 stops7h 38m
Wed 10/2112:20 pm -
1 stop8h 11m
Deal found 8/22![United Airlines logo]()
$284
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:00 am -
1 stop3h 14m
Mon 9/146:36 pm -
1 stop3h 23m
Deal found 8/22![Delta logo]()
$306
This Southwest deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:10 pm -
1 stop4h 25m
Fri 11/276:45 am -
1 stop5h 25m
Deal found 8/21![Southwest logo]()
$309
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
2 stops7h 45m
Mon 10/56:08 pm -
1 stop6h 00m
Deal found 8/21![American Airlines logo]()
$375
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:10 am -
2 stops7h 40m
Mon 9/145:45 am -
1 stop4h 33m
Deal found 8/17![United Airlines logo]()
$291
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:09 am -
1 stop5h 51m
Wed 9/305:30 am -
1 stop4h 49m
Deal found 8/22![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/247:27 pm -
1 stop3h 27m
Sun 9/275:10 am -
1 stop5h 56m
Deal found 8/19![American Airlines logo]()
$377
This Southwest deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/64:00 pm -
1 stop4h 55m
Tue 10/136:40 am -
1 stop5h 35m
Deal found 8/22![Southwest logo]()
$315
Last-minute flights from Louisville to South CarolinaDiscover last-minute flight deals from Louisville to South Carolina. Data last updated August 23, 2026 and is based on user searches.
Discover last-minute flight deals from Louisville to South Carolina. Data last updated August 23, 2026 and is based on user searches.
This Breeze Airways deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/288:28 pm -
Nonstop1h 38m
Mon 8/317:00 am -
Nonstop1h 46m
Deal found 8/18![Breeze Airways logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:59 pm -
Nonstop1h 35m
Mon 9/146:10 am -
Nonstop1h 52m
Deal found 8/17![Breeze Airways logo]()
$113
This Kiwi.com deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:59 pm -
Nonstop1h 35m
Mon 9/216:10 am -
Nonstop1h 52m
Deal found 8/22![Breeze Airways logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:59 pm -
Nonstop1h 35m
Fri 9/186:10 am -
Nonstop1h 52m
Deal found 8/22![Breeze Airways logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:59 pm -
Nonstop1h 35m
Mon 9/216:10 am -
Nonstop1h 52m
Deal found 8/22![Breeze Airways logo]()
$162
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/151:15 pm -
1 stop4h 48m
Tue 9/226:58 pm -
1 stop5h 01m
Deal found 8/19![Delta logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:59 pm -
Nonstop1h 35m
Mon 9/216:10 am -
Nonstop1h 52m
Deal found 8/18![Breeze Airways logo]()
$117
This Southwest deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1912:05 pm -
1 stop6h 20m
Sat 9/261:00 pm -
1 stop4h 20m
Deal found 8/21![Southwest logo]()
$277
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:00 am -
1 stop4h 37m
Tue 9/292:15 pm -
1 stop4h 55m
Deal found 8/22![American Airlines logo]()
$271
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/221:56 pm -
1 stop5h 09m
Wed 9/237:47 pm -
1 stop4h 12m
Deal found 8/20![United Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:59 pm -
Nonstop1h 35m
Mon 9/286:10 am -
Nonstop1h 52m
Deal found 8/22![Breeze Airways logo]()
$143
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/292:53 pm -
1 stop6h 15m
Thu 10/15:32 pm -
1 stop5h 50m
Deal found 8/18![American Airlines logo]()
$279
One-way flights from Louisville to South CarolinaSearch for one-way flight options from Louisville to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 23, 2026.
Search for one-way flight options from Louisville to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:59 pm -
Nonstop1h 35m
Deal found 8/21![Breeze Airways logo]()
$49
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:59 pm -
Nonstop1h 35m
Deal found 8/17![Breeze Airways logo]()
$53
This Breeze Airways deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:59 pm -
Nonstop1h 35m
Deal found 8/21![Breeze Airways logo]()
$64
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:59 pm -
Nonstop1h 35m
Deal found 8/20![Breeze Airways logo]()
$78
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:15 am -
1 stop5h 22m
Deal found 8/18![United Airlines logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/159:09 pm -
1 stop14h 35m
Deal found 8/18![Breeze Airways logo]()
$132
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:45 am -
2 stops10h 35m
Deal found 8/18![Southwest logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1210:25 am -
1 stop10h 57m
Deal found 8/21![Breeze Airways logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:06 pm -
2 stops13h 29m
Deal found 8/18![Multiple Airlines logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:09 pm -
1 stop14h 35m
Deal found 8/21![Breeze Airways logo]()
$138
This Southwest deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1912:05 pm -
1 stop6h 20m
Deal found 8/19![Southwest logo]()
$139
This Southwest deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:20 pm -
1 stop4h 05m
Deal found 8/22![Southwest logo]()
$140
Find flight deals from Louisville to South Carolina
Keep the following information in mind while searching for Louisville to South Carolina flight deals. Data was last updated August 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $97 (Kiwi.com) |
One-way from | $49 (Kiwi.com) |
Popular in | January |
Cheapest in | July |
Average price | $327 |
Good round-trip deal | $80 or less |
Good one-way deal | $84 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Louisville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 23, 2026.
Use the filters below to find and compare flights from Louisville to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Fri 10/9
5:57 pm-11:59 pm
1 stop6h 02m
Charleston
Fri 10/16
4:20 pm-10:37 pm
1 stop6h 17m
$257
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Wed 9/9
8:45 am-7:20 pm
2 stops10h 35m
Charleston
Thu 9/10
1:15 pm-10:00 pm
2 stops8h 45m
$267
LouisvilleHilton Head Island
SDF Louisville Intl - HHH Hilton Head Island
SDFHHH
Louisville Intl
Wed 10/21
6:15 am-12:35 pm
1 stop6h 20m
Hilton Head Island
Sat 10/24
2:51 pm-8:31 pm
1 stop5h 40m
$271
LouisvilleHilton Head Island
SDF Louisville Intl - HHH Hilton Head Island
SDFHHH
Louisville Intl
Tue 9/22
6:00 am-10:37 am
1 stop4h 37m
Hilton Head Island
Tue 9/29
2:15 pm-7:10 pm
1 stop4h 55m
$271
LouisvilleMyrtle Beach
SDF Louisville Intl - MYR Myrtle Beach Intl
SDFMYR
Louisville Intl
Sat 10/24
6:00 am-10:07 am
1 stop4h 07m
Myrtle Beach Intl
Tue 10/27
2:16 pm-7:10 pm
1 stop4h 54m
$279
LouisvilleGreenville
SDF Louisville Intl - GSP Greenville
SDFGSP
Louisville Intl
Tue 9/22
1:56 pm-7:05 pm
1 stop5h 09m
Greenville
Wed 9/23
7:47 pm-11:59 pm
1 stop4h 12m
$279
LouisvilleSavannah
SDF Louisville Intl - SAV Savannah/Hilton Head
SDFSAV
Louisville Intl
Sat 10/31
2:15 pm-9:24 pm
1 stop7h 09m
Savannah/Hilton Head
Mon 11/2
11:19 am-5:37 pm
1 stop6h 18m
$279
LouisvilleColumbia
SDF Louisville Intl - CAE Columbia Metropolitan
SDFCAE
Louisville Intl
Sat 11/14
7:05 am-11:08 am
1 stop4h 03m
Columbia Metropolitan
Sat 11/21
6:04 pm-11:13 pm
1 stop5h 09m
$281
LouisvilleCharlotte
SDF Louisville Intl - CLT Charlotte Douglas
SDFCLT
Louisville Intl
Wed 9/9
1:50 pm-9:00 pm
1 stop7h 10m
Charlotte Douglas
Sat 9/12
12:34 pm-8:32 pm
1 stop7h 58m
$283
LouisvilleSavannah
SDF Louisville Intl - SAV Savannah/Hilton Head
SDFSAV
Louisville Intl
Sat 10/17
3:35 pm-7:50 pm
1 stop4h 15m
Savannah/Hilton Head
Wed 10/21
6:50 am-3:15 pm
2 stops8h 25m
$284
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Louisville to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Louisville with our price prediction graph.
SDF-CHS
SDF-CLT
SDF-MYR
SDF-HHH
SDF-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Louisville to South Carolina
SDF-USSC
SDF-CHS
SDF-CLT
SDF-MYR
SDF-HHH
What is the cheapest month to book a flight from Louisville to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Louisville to South Carolina (average of $230). Flying from Louisville to South Carolina in April is currently the most expensive (average of $406). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SDF to SC?
Find hourly flight availability from Louisville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 23, 2026.
A simple way to save on the total cost of your ticket is to fly from Louisville to South Carolina in the morning. If you’re flexible enough to do this you can expect to save up to 70% on your trip compared to booking a flight at noon.
How much does it cost to fly round-trip from Louisville to South Carolina?
Airfare is below average for this route at the moment.
Louisville to South Carolina flights typically cost between $170 and $370 in October.The cheapest round-trip price found within the last 5 days was $97 on Breeze Airways (Oct 30-Nov 2).
How far ahead should I book a flight from Louisville to South Carolina?
To ensure you get the cheapest price possible for a flight from Louisville to South Carolina, you should look to book at least 31 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 23, 2026.
Get a feel of what it's like to fly with Breeze Airways,Southwest, andDelta from Louisville to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.2
Food
6.7
Boarding
8.3
Entertainment
6.7
Comfort
8.2
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Overall
8.2
Food
6.7
Boarding
8.3
Entertainment
6.7
Comfort
8.2
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Overall
8.2
Food
6.7
Boarding
8.3
Entertainment
6.7
Comfort
8.2
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Overall
8.2
Food
6.7
Boarding
8.3
Entertainment
6.7
Comfort
8.2
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Overall
8.2
Food
6.7
Boarding
8.3
Entertainment
6.7
Comfort
8.2
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Overall
8.2
Food
6.7
Boarding
8.3
Entertainment
6.7
Comfort
8.2
Crew
8.8
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Related info for your journey
Find useful and relevant information for your journey from Louisville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Louisville and South Carolina flights
Browse other Louisville and South Carolina flight options. Last updated on August 23, 2026.
Popular flight searches
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Louisville to South Carolina flights
Consider these flights traveling from Louisville to South Carolina.
Top 6 airlines flying from Louisville to South Carolina
Discover the top 6 airlines that operate flights from Louisville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$63 | Average$134 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$88 | Average$153 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$134 | Average$379 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$228 | Average$367 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$388 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$274 | Average$443 | FlexibilityNo cancel fee | On-time69% |