HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$82+ Cheap flights from Louisville (SDF) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/26. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — CHS
Apr 18 — Apr 251
Sat 4/18
Sat 4/25
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Louisville to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Louisville to South Carolina

Cheapest flights from Louisville to South Carolina
Explore the most affordable flight options available from Louisville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 19, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Fri 8/287:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 3/13$92
This Super.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Fri 9/47:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 3/18$109
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Mon 9/77:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 3/18$118
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/148:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Mon 8/177:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 3/17$119
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/278:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Mon 8/37:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 3/17$123
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2311:28 am
SDF
-
SAV
Nonstop1h 34m
Allegiant Air
Sun 7/268:30 am
SAV
-
SDF
Nonstop1h 38m
Allegiant Air
Deal found 3/15$125
This Booking.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Mon 6/87:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 3/18$126
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/911:28 am
SDF
-
SAV
Nonstop1h 34m
Allegiant Air
Sun 7/128:30 am
SAV
-
SDF
Nonstop1h 38m
Allegiant Air
Deal found 3/18$127
This Booking.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/88:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Fri 6/127:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 3/18$127
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/288:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Mon 9/77:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 3/18$129
This Booking.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/108:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Fri 7/177:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Deal found 3/15$130
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:10 pm
SDF
-
SAV
Nonstop1h 31m
Allegiant Air
Thu 7/29:00 am
SAV
-
SDF
Nonstop1h 38m
Allegiant Air
Deal found 3/16$133

Find flight deals from Louisville to South Carolina

Keep the following information in mind while searching for Louisville to South Carolina flight deals. Data was last updated March 19, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$92
(Kiwi.com)

One-way from

$82
(Booking.com)

Popular in

January

Cheapest in

July

Average price

$325

Good round-trip deal

$134 or less
Provider with most accurate pricing for Louisville Intl-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Louisville Intl-Myrtle Beach Intl flights.
Search Deals
From Louisville Intl to South Carolina
Search Deals
One-way flight from Louisville Intl to South Carolina
Search Deals
Highest demand for flights based on searches. 26% potential increase in price ($103 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals
Price to beat on a round-trip flight from Louisville Intl to South Carolina.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 19, 2026.
Use the filters below to find and compare flights from Louisville to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Fri 8/14

8:28 pm-10:06 pm

Nonstop1h 38m

Charleston

Mon 8/17

3:54 pm-8:48 pm

1 stop4h 54m

$184

LouisvilleMyrtle Beach

SDF - MYR

SDFMYR

Louisville Intl

Sat 5/2

3:15 pm-6:15 pm

1 stop3h 00m

Myrtle Beach Intl

Tue 5/5

4:05 pm-9:05 pm

1 stop5h 00m

$275

LouisvilleHilton Head Island

SDF - HHH

SDFHHH

Louisville Intl

Sat 4/11

9:54 am-3:40 pm

1 stop5h 46m

Hilton Head Island

Tue 4/14

5:51 pm-11:30 pm

1 stop5h 39m

$289

LouisvilleMyrtle Beach

SDF - MYR

SDFMYR

Louisville Intl

Tue 4/14

3:45 pm-8:30 pm

1 stop4h 45m

Myrtle Beach Intl

Thu 4/16

7:20 pm-11:45 pm

1 stop4h 25m

$293

LouisvilleMyrtle Beach

SDF - MYR

SDFMYR

Louisville Intl

Tue 5/12

6:00 am-12:40 pm

1 stop6h 40m

Myrtle Beach Intl

Wed 5/20

4:07 pm-9:51 pm

1 stop5h 44m

$303

LouisvilleHilton Head Island

SDF - HHH

SDFHHH

Louisville Intl

Tue 3/31

6:33 am-4:44 pm

2 stops10h 11m

Hilton Head Island

Sat 4/4

2:58 pm-9:24 pm

1 stop6h 26m

$304

LouisvilleColumbia

SDF - CAE

SDFCAE

Louisville Intl

Sat 5/2

6:00 am-11:29 am

1 stop5h 29m

Columbia Metropolitan

Sat 5/9

3:54 pm-10:01 pm

1 stop6h 07m

$309

LouisvilleGreenville

SDF - GSP

SDFGSP

Louisville Intl

Thu 4/16

6:55 am-12:00 pm

1 stop5h 05m

Greenville

Sat 4/18

8:00 am-12:55 pm

1 stop4h 55m

$313

LouisvilleColumbia

SDF - CAE

SDFCAE

Louisville Intl

Sat 5/2

9:10 am-7:03 pm

2 stops9h 53m

Columbia Metropolitan

Sat 5/9

7:38 pm-11:59 pm

1 stop4h 21m

$314

LouisvilleMyrtle Beach

SDF - MYR

SDFMYR

Louisville Intl

Sun 5/24

6:00 am-10:15 am

1 stop4h 15m

Myrtle Beach Intl

Wed 5/27

7:35 am-12:40 pm

1 stop5h 05m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/15

Showing 1-10 of 60 resultsSorted by cheapest first
1
2
3
...
6

Best time to book a flight from Louisville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to South Carolina

What is the cheapest month to book a flight from Louisville to South Carolina?

Currently, October is the cheapest month in which you can book a flight from Louisville to South Carolina (average of $41). Flying from Louisville to South Carolina in February is currently the most expensive (average of $92). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDF to SC?

Find hourly flight availability from Louisville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 19, 2026.

A simple way to save on the total cost of your ticket is to fly from Louisville to South Carolina in the afternoon. If you’re flexible enough to do this you can expect to save up to 50% on your trip compared to booking a flight at noon.

What is the cheapest day to fly from Louisville to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Louisville to South Carolina. Price data was last updated on March 14, 2026.

Travelers seeking maximum savings on their Louisville to South Carolina flight should consider departing on Saturday at noon when fares are most often at their lowest. Friday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 19, 2026.
Get a feel of what it's like to fly with Breeze Airways,Delta, andAllegiant Air from Louisville to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Breeze Airways
8.1
Very good
271 reviews

Overall

8.1

Boarding

8.3

Entertainment

6.6

Comfort

8.2

Food

6.6

Crew

8.7

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Breeze Airways
8.1
Very good
271 reviews
Breeze Airways
8.1
Very good
271 reviews

Overall

8.1

Boarding

8.3

Entertainment

6.6

Comfort

8.2

Food

6.6

Crew

8.7

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Delta
7.9
Good
8,296 reviews
Breeze Airways
8.1
Very good
271 reviews

Overall

8.1

Boarding

8.3

Entertainment

6.6

Comfort

8.2

Food

6.6

Crew

8.7

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Allegiant Air
7.3
Good
713 reviews
Breeze Airways
8.1
Very good
271 reviews

Overall

8.1

Boarding

8.3

Entertainment

6.6

Comfort

8.2

Food

6.6

Crew

8.7

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
American Airlines
7.1
Good
11,475 reviews
Breeze Airways
8.1
Very good
271 reviews

Overall

8.1

Boarding

8.3

Entertainment

6.6

Comfort

8.2

Food

6.6

Crew

8.7

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Spirit Airlines
6.3
Okay
8,528 reviews
Breeze Airways
8.1
Very good
271 reviews

Overall

8.1

Boarding

8.3

Entertainment

6.6

Comfort

8.2

Food

6.6

Crew

8.7

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.

Related info for your journey

Find useful and relevant information for your journey from Louisville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Louisville to South Carolina?

    Most people fly from Louisville Intl (SDF) if they book a flight from Louisville to South Carolina. Louisville Intl is conveniently located just 5.3 mi from Louisville’s city center.

  • How popular is this Louisville to South Carolina flight route?

    The Louisville Intl to South Carolina flight path was viewed by 5 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Louisville to South Carolina?

    A quick flight from Louisville to South Carolina can take about 3h. Southwest provides one of the quickest options available for as low as $275. The distance from Louisville to South Carolina is about 491 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Louisville to South Carolina one-way?

    For one-way options, check prices for Spirit Airlines. According to our data, you can fly for as low as $37. Users have also found prices from $49 and $114 on Breeze Airways and American Airlines, respectively.

  • What are the most popular routes from Louisville to South Carolina?

    The most popular flight routes from Louisville to South Carolina are Louisville Intl - Savannah/Hilton Head, Louisville Intl - Charleston and Louisville Intl - Myrtle Beach Intl.

  • What are the cheapest flights from Louisville to South Carolina?

    Looking for the cheapest flight from Louisville to South Carolina? While on average our users pay $139, our data indicates the cheapest price to be $130. The most popular route (Louisville Intl - Savannah/Hilton Head), is priced around $125.

  • Can I find deals for flights from Louisville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Louisville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to South Carolina.

  • Can I find deals for business class flights from Louisville to South Carolina?

    Yes. Cheapflights offers flight deals from Louisville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Louisville to South Carolina (average of $41). Flying from Louisville to South Carolina in February is currently the most expensive (average of $92). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Louisville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Cincinnati to Orlando flights
Cincinnati to Las Vegas flights
Cincinnati to Tampa flights
Cincinnati to Fort Lauderdale flights
Cincinnati to Seattle flights
Cincinnati to LaGuardia flights
Cincinnati to Denver flights
Nashville to John F Kennedy Intl flights
Nashville to Los Angeles flights
Cincinnati to Newark flights
Nashville to Seattle flights
Nashville to LaGuardia flights
Cincinnati to John F Kennedy Intl flights
Cincinnati to Miami flights
Nashville to Newark flights
Nashville to Dallas/Fort Worth flights
Cincinnati to Dallas/Fort Worth flights
Cincinnati to Los Angeles flights
Nashville to Las Vegas flights
Cincinnati to Fort Myers flights
Nashville to Hobby flights
Nashville to Denver flights
Cincinnati to Hobby flights
Nashville to O'Hare Intl flights
Nashville to Orlando flights
Cincinnati to Boston flights
Louisville to Las Vegas flights
Cincinnati to Sky Harbor Intl flights
Nashville to Miami flights
Cincinnati to Orlando Sanford Intl flights
Nashville to Boston flights
Nashville to Fort Lauderdale flights
Nashville to Reagan-National flights
Nashville to San Francisco flights
Cincinnati to Austin flights
Knoxville to LaGuardia flights
Nashville to Dulles Intl flights
Nashville to Philadelphia flights
Nashville to Sky Harbor Intl flights
Cincinnati to George Bush Intcntl flights
Nashville to George Bush Intcntl flights
Cincinnati to St Petersburg flights
Nashville to Baltimore flights
Cincinnati to Reagan-National flights
Knoxville to Denver flights
Cincinnati to Atlanta flights
Nashville to Tampa flights
Louisville to Dallas/Fort Worth flights
Cincinnati to Sarasota flights
Cincinnati to Salt Lake City flights

Top 7 airlines flying from Louisville to South Carolina

Discover the top 7 airlines that operate flights from Louisville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 19, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$60Average$136FlexibilityNo cancel feeOn-time88%
Breeze AirwaysCheapest$71Average$129FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$83Average$133FlexibilityNo cancel feeOn-time65%
DeltaCheapest$118Average$308FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$148Average$468FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$183Average$329FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$219Average$363FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.