$53+ Cheap flights from Louisville (SDF) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — CHS
Nov 20 — Nov 271
Round-trip
1 adult, Economy
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Find cheap flights from Louisville to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Louisville to South Carolina
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Cheapest flights from Louisville to South CarolinaExplore the most affordable flight options available from Louisville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 21, 2026.
Explore the most affordable flight options available from Louisville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/117:59 pm -
Nonstop1h 35m
Mon 12/146:10 am -
Nonstop1h 52m
Deal found 10/19![Breeze Airways logo]()
$122
This Super.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:59 pm -
Nonstop1h 35m
Fri 11/136:10 am -
Nonstop1h 52m
Deal found 10/18![Breeze Airways logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:59 pm -
Nonstop1h 35m
Mon 11/166:10 am -
Nonstop1h 52m
Deal found 10/18![Breeze Airways logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:59 pm -
Nonstop1h 35m
Mon 11/166:10 am -
Nonstop1h 52m
Deal found 10/18![Breeze Airways logo]()
$130
This Breeze Airways deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:59 pm -
Nonstop1h 35m
Fri 11/66:10 am -
Nonstop1h 52m
Deal found 10/18![Breeze Airways logo]()
$133
This Breeze Airways deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:59 pm -
Nonstop1h 35m
Mon 11/96:10 am -
Nonstop1h 52m
Deal found 10/20![Breeze Airways logo]()
$138
This Breeze Airways deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/410:25 am -
1 stop6h 18m
Mon 12/76:10 am -
Nonstop1h 52m
Deal found 10/20![Breeze Airways logo]()
$141
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:00 pm -
1 stop5h 01m
Tue 11/108:11 am -
1 stop3h 45m
Deal found 10/19![Delta logo]()
$245
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:35 pm -
1 stop5h 25m
Tue 11/108:05 am -
2 stops12h 30m
Deal found 10/19![Southwest logo]()
$250
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/91:01 pm -
1 stop5h 04m
Wed 11/186:58 pm -
1 stop4h 15m
Deal found 10/19![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/43:50 pm -
1 stop5h 00m
Sun 12/68:15 am -
1 stop4h 15m
Deal found 10/19![Southwest logo]()
$267
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/91:01 pm -
1 stop5h 04m
Mon 11/166:51 pm -
1 stop5h 19m
Deal found 10/19![Delta logo]()
$269
Best flights from Louisville to South CarolinaDiscover carefully curated flight deals from Louisville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 21, 2026.
Discover carefully curated flight deals from Louisville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 21, 2026.
This Breeze Airways deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:59 pm -
Nonstop1h 35m
Mon 11/96:10 am -
Nonstop1h 52m
Deal found 10/16![Breeze Airways logo]()
$143
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:57 pm -
1 stop6h 02m
Mon 11/97:04 pm -
1 stop5h 06m
Deal found 10/16![Delta logo]()
$237
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:10 pm -
1 stop5h 10m
Mon 12/146:35 am -
2 stops8h 40m
Deal found 10/18![Southwest logo]()
$242
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/119:50 am -
2 stops7h 58m
Sun 1/1711:27 am -
2 stops8h 03m
Deal found 10/19![United Airlines logo]()
$304
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:04 am -
1 stop3h 43m
Sat 11/218:28 pm -
1 stop3h 41m
Deal found 10/16![American Airlines logo]()
$321
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/115:35 am -
1 stop4h 25m
Sun 1/178:00 am -
1 stop4h 55m
Deal found 10/20![Southwest logo]()
$254
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:00 pm -
1 stop3h 14m
Thu 11/1212:12 pm -
1 stop4h 42m
Deal found 10/20![Delta logo]()
$295
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:10 pm -
1 stop4h 35m
Thu 11/126:40 am -
1 stop5h 30m
Deal found 10/18![Southwest logo]()
$270
This Breeze Airways deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2310:25 am -
1 stop6h 18m
Fri 11/276:10 am -
Nonstop1h 52m
Deal found 10/19![Breeze Airways logo]()
$326
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:11 pm -
1 stop3h 16m
Tue 11/248:35 pm -
1 stop3h 45m
Deal found 10/16![American Airlines logo]()
$331
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/77:10 am -
1 stop6h 50m
Fri 12/113:30 pm -
1 stop8h 29m
Deal found 10/19![United Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/21:02 pm -
1 stop3h 35m
Sat 12/56:12 am -
1 stop5h 28m
Deal found 10/16![American Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/48:50 am -
2 stops9h 20m
Sun 12/66:40 am -
2 stops8h 45m
Deal found 10/19![Southwest logo]()
$308
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/29:50 am -
2 stops7h 58m
Wed 2/36:29 pm -
1 stop5h 15m
Deal found 10/20![United Airlines logo]()
$340
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:00 am -
1 stop5h 34m
Fri 11/2011:06 am -
1 stop6h 20m
Deal found 10/16![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
1 stop4h 07m
Mon 11/96:51 pm -
1 stop4h 02m
Deal found 10/21![Delta logo]()
$377
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:17 am -
2 stops9h 44m
Wed 11/115:40 am -
1 stop7h 23m
Deal found 10/20![United Airlines logo]()
$350
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/207:00 am -
1 stop3h 53m
Wed 3/242:15 pm -
1 stop6h 36m
Deal found 10/18![Delta logo]()
$377
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/111:50 am -
1 stop5h 20m
Fri 11/205:47 pm -
1 stop6h 33m
Deal found 10/16![American Airlines logo]()
$354
This Southwest deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/243:50 pm -
1 stop3h 35m
Fri 12/258:10 am -
1 stop4h 50m
Deal found 10/17![Southwest logo]()
$377
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:05 am -
1 stop4h 02m
Sun 11/297:19 pm -
1 stop4h 51m
Deal found 10/19![Delta logo]()
$391
This Southwest deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/15:40 am -
1 stop4h 25m
Sun 12/68:20 am -
2 stops13h 20m
Deal found 10/17![Southwest logo]()
$382
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:10 am -
2 stops9h 07m
Tue 11/2410:16 am -
2 stops10h 36m
Deal found 10/20![United Airlines logo]()
$430
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:13 am -
1 stop6h 01m
Mon 11/164:44 pm -
1 stop4h 53m
Deal found 10/18![American Airlines logo]()
$395
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:00 am -
1 stop5h 07m
Sat 11/285:40 am -
1 stop3h 26m
Deal found 10/18![Delta logo]()
$427
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:40 am -
1 stop4h 25m
Thu 11/127:35 pm -
1 stop4h 50m
Deal found 10/18![Southwest logo]()
$390
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:55 am -
1 stop4h 33m
Tue 11/1011:12 am -
2 stops8h 18m
Deal found 10/16![United Airlines logo]()
$462
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:50 am -
1 stop5h 18m
Wed 11/255:47 pm -
1 stop5h 27m
Deal found 10/21![American Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:05 am -
1 stop3h 38m
Sun 11/110:10 am -
1 stop4h 31m
Deal found 10/20![Delta logo]()
$436
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/912:05 pm -
2 stops8h 55m
Thu 11/126:35 am -
2 stops10h 00m
Deal found 10/19![Southwest logo]()
$436
Last-minute flights from Louisville to South CarolinaDiscover last-minute flight deals from Louisville to South Carolina. Data last updated October 21, 2026 and is based on user searches.
Discover last-minute flight deals from Louisville to South Carolina. Data last updated October 21, 2026 and is based on user searches.
This Super.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:59 pm -
Nonstop1h 35m
Mon 11/26:10 am -
Nonstop1h 52m
Deal found 10/17![Breeze Airways logo]()
$158
This Breeze Airways deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:59 pm -
Nonstop1h 35m
Fri 11/66:10 am -
Nonstop1h 52m
Deal found 10/18![Breeze Airways logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:59 pm -
Nonstop1h 35m
Mon 11/166:10 am -
Nonstop1h 52m
Deal found 10/18![Breeze Airways logo]()
$130
This Breeze Airways deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:59 pm -
Nonstop1h 35m
Mon 11/96:10 am -
Nonstop1h 52m
Deal found 10/19![Breeze Airways logo]()
$138
This Super.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:59 pm -
Nonstop1h 35m
Fri 11/136:10 am -
Nonstop1h 52m
Deal found 10/18![Breeze Airways logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:59 pm -
Nonstop1h 35m
Mon 11/166:10 am -
Nonstop1h 52m
Deal found 10/18![Breeze Airways logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:59 pm -
Nonstop1h 35m
Thu 11/124:47 pm -
1 stop16h 58m
Deal found 10/16![Breeze Airways logo]()
$191
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:00 pm -
1 stop5h 01m
Tue 11/108:11 am -
1 stop3h 45m
Deal found 10/19![Delta logo]()
$245
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:35 pm -
1 stop5h 25m
Tue 11/108:05 am -
2 stops12h 30m
Deal found 10/19![Southwest logo]()
$250
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/91:01 pm -
1 stop5h 04m
Wed 11/186:58 pm -
1 stop4h 15m
Deal found 10/19![Delta logo]()
$257
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/91:01 pm -
1 stop5h 04m
Tue 11/176:58 pm -
1 stop4h 15m
Deal found 10/19![Delta logo]()
$269
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:04 am -
1 stop3h 44m
Sun 11/227:09 am -
1 stop5h 34m
Deal found 10/20![American Airlines logo]()
$177
One-way flights from Louisville to South CarolinaSearch for one-way flight options from Louisville to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 21, 2026.
Search for one-way flight options from Louisville to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:59 pm -
Nonstop1h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Breeze Airways logo]()
$53
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/17:59 pm -
Nonstop1h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Breeze Airways logo]()
$59
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/47:59 pm -
Nonstop1h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Breeze Airways logo]()
$64
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/217:59 pm -
Nonstop1h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Breeze Airways logo]()
$73
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2411:24 am -
1 stop5h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![American Airlines logo]()
$89
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/412:05 pm -
2 stops8h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Southwest logo]()
$94
This Southwest deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/217:15 pm -
1 stop5h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Southwest logo]()
$119
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/305:59 pm -
1 stop4h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Delta logo]()
$123
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/248:50 am -
2 stops8h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Southwest logo]()
$135
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:10 am -
1 stop5h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Southwest logo]()
$255
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:04 am -
1 stop5h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![American Airlines logo]()
$267
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/296:00 am -
1 stop3h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Delta logo]()
$269
Find flight deals from Louisville to South Carolina
Keep the following information in mind while searching for Louisville to South Carolina flight deals. Data was last updated October 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $122 (Kiwi.com) |
One-way from | $53 (Kiwi.com) |
Popular in | January |
Cheapest in | July |
Average price | $338 |
Good round-trip deal | $127 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Louisville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 21, 2026.
Use the filters below to find and compare flights from Louisville to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Mon 11/9
7:59 pm-9:34 pm
Nonstop1h 35m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$53
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Mon 12/21
7:15 pm-12:15 am
1 stop5h 00m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$119
LouisvilleMyrtle Beach
SDF Louisville Intl - MYR Myrtle Beach Intl
SDFMYR
Louisville Intl
Mon 11/30
5:59 pm-10:54 pm
1 stop4h 55m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$123
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Thu 1/7
12:53 pm-4:51 pm
1 stop3h 58m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$130
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Tue 1/5
6:00 am-11:26 am
1 stop5h 26m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$130
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Thu 12/24
8:50 am-5:25 pm
2 stops8h 35m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$135
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Mon 11/9
6:53 pm-12:31 pm
2 stops17h 38m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$142
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Fri 11/6
7:59 pm-9:34 pm
Nonstop1h 35m
Charleston
Mon 11/9
6:10 am-8:02 am
Nonstop1h 52m
$143
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Wed 1/6
8:50 am-7:08 pm
2 stops10h 18m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$180
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Wed 11/4
4:06 pm-8:38 am
2 stops16h 32m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$189
Showing 1-10 of 52 resultsSorted by cheapest first
Best time to book a flight from Louisville to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Louisville with our price prediction graph.
SDF-CHS
SDF-MYR
SDF-HHH
SDF-GSP
SDF-CAE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Louisville to South Carolina
SDF-USSC
SDF-CHS
SDF-MYR
SDF-HHH
SDF-GSP
What is the cheapest month to book a flight from Louisville to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Louisville to South Carolina (average of $230). Flying from Louisville to South Carolina in September is currently the most expensive (average of $429). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SDF to SC?
Find hourly flight availability from Louisville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 21, 2026.
A simple way to save on the total cost of your ticket is to fly from Louisville to South Carolina in the morning. If you’re flexible enough to do this you can expect to save up to 70% on your trip compared to booking a flight at noon.
How much does it cost to fly round-trip from Louisville to South Carolina?
Airfare is below average for this route at the moment.
Louisville to South Carolina flights typically cost between $142 and $406 in December.The cheapest round-trip price found within the last 5 days was $122 on Breeze Airways (Dec 11-Dec 14).
How far ahead should I book a flight from Louisville to South Carolina?
To ensure you get the cheapest price possible for a flight from Louisville to South Carolina, you should look to book at least 57 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 21, 2026.
Get a feel of what it's like to fly with Breeze Airways,Southwest, andDelta from Louisville to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.4
Overall
8.2
Crew
8.8
Entertainment
6.8
Food
6.7
Comfort
8.2
Reviews
1 / 19
10.0
ExcellentJames,Oct 2026
RSW - RDU
Boarding
8.4
Overall
8.2
Crew
8.8
Entertainment
6.8
Food
6.7
Comfort
8.2
Reviews
1 / 19
10.0
ExcellentJames,Oct 2026
RSW - RDU
Boarding
8.4
Overall
8.2
Crew
8.8
Entertainment
6.8
Food
6.7
Comfort
8.2
Reviews
1 / 19
10.0
ExcellentJames,Oct 2026
RSW - RDU
Boarding
8.4
Overall
8.2
Crew
8.8
Entertainment
6.8
Food
6.7
Comfort
8.2
Reviews
1 / 19
10.0
ExcellentJames,Oct 2026
RSW - RDU
Boarding
8.4
Overall
8.2
Crew
8.8
Entertainment
6.8
Food
6.7
Comfort
8.2
Reviews
1 / 19
10.0
ExcellentJames,Oct 2026
RSW - RDU
Boarding
8.4
Overall
8.2
Crew
8.8
Entertainment
6.8
Food
6.7
Comfort
8.2
Reviews
1 / 19
10.0
ExcellentJames,Oct 2026
RSW - RDU
Related info for your journey
Find useful and relevant information for your journey from Louisville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Louisville to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Louisville to South Carolina by cabin class
Find flights from Louisville to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Louisville and South Carolina flights
Browse other Louisville and South Carolina flight options. Last updated on October 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Louisville to South Carolina flights
Consider these flights traveling from Louisville to South Carolina.
Top 6 airlines flying from Louisville to South Carolina
Discover the top 6 airlines that operate flights from Louisville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$63 | Average$134 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$88 | Average$154 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$230 | Average$401 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$234 | Average$351 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$234 | Average$392 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$388 | FlexibilityNo cancel fee | On-time63% |