$54+ Cheap flights from Louisville (SDF) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — CHS
Oct 8 — Oct 151
Round-trip
1 adult, Economy
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Find cheap flights from Louisville to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Louisville to South Carolina
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Cheapest flights from Louisville to South CarolinaExplore the most affordable flight options available from Louisville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
Explore the most affordable flight options available from Louisville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:59 pm -
Nonstop1h 35m
Mon 12/76:10 am -
Nonstop1h 52m
Deal found 9/8![Breeze Airways logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:59 pm -
Nonstop1h 35m
Mon 11/26:10 am -
Nonstop1h 52m
Deal found 9/4![Breeze Airways logo]()
$102
This Breeze Airways deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:59 pm -
Nonstop1h 35m
Mon 12/76:10 am -
Nonstop1h 52m
Deal found 9/7![Breeze Airways logo]()
$103
This Breeze Airways deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:59 pm -
Nonstop1h 35m
Mon 9/216:10 am -
Nonstop1h 52m
Deal found 9/4![Breeze Airways logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/27:59 pm -
Nonstop1h 35m
Mon 10/56:10 am -
Nonstop1h 52m
Deal found 9/6![Breeze Airways logo]()
$117
This Priceline deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:59 pm -
Nonstop1h 35m
Fri 10/306:10 am -
Nonstop1h 52m
Deal found 9/7![Breeze Airways logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:59 pm -
Nonstop1h 35m
Mon 10/126:10 am -
Nonstop1h 52m
Deal found 9/6![Breeze Airways logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:59 pm -
Nonstop1h 35m
Mon 10/266:10 am -
Nonstop1h 52m
Deal found 9/7![Breeze Airways logo]()
$137
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:04 am -
1 stop6h 01m
Sat 10/312:56 pm -
1 stop4h 40m
Deal found 9/7![American Airlines logo]()
$271
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
1 stop4h 07m
Wed 10/2110:52 am -
1 stop5h 57m
Deal found 9/7![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/32:12 pm -
1 stop5h 28m
Wed 10/73:24 pm -
1 stop8h 17m
Deal found 9/8![United Airlines logo]()
$279
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:02 pm -
1 stop3h 56m
Tue 11/106:00 am -
1 stop6h 43m
Deal found 9/4![American Airlines logo]()
$281
Best flights from Louisville to South CarolinaDiscover carefully curated flight deals from Louisville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
Discover carefully curated flight deals from Louisville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
This Breeze Airways deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1810:25 am -
1 stop6h 18m
Mon 9/216:10 am -
Nonstop1h 52m
Deal found 9/4![Breeze Airways logo]()
$171
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/233:30 pm -
1 stop8h 50m
Fri 10/308:05 pm -
1 stop4h 10m
Deal found 9/3![Southwest logo]()
$262
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:00 am -
2 stops12h 08m
Tue 11/105:37 pm -
1 stop4h 53m
Deal found 9/4![United Airlines logo]()
$286
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:57 pm -
1 stop5h 50m
Mon 10/127:19 pm -
1 stop4h 40m
Deal found 9/3![Delta logo]()
$299
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:00 am -
1 stop4h 37m
Mon 11/24:37 pm -
1 stop5h 00m
Deal found 9/6![American Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:10 am -
2 stops10h 20m
Mon 11/1610:45 am -
2 stops11h 05m
Deal found 9/8![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:00 am -
1 stop5h 12m
Sun 9/273:53 pm -
1 stop4h 40m
Deal found 9/4![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:10 am -
1 stop4h 41m
Wed 11/115:50 am -
1 stop7h 13m
Deal found 9/7![United Airlines logo]()
$327
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:04 am -
1 stop3h 20m
Sun 10/188:33 pm -
1 stop3h 35m
Deal found 9/4![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:10 pm -
1 stop5h 05m
Wed 11/116:35 am -
2 stops8h 40m
Deal found 9/4![Southwest logo]()
$316
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:57 pm -
1 stop3h 50m
Sun 10/115:40 am -
1 stop3h 17m
Deal found 9/8![Delta logo]()
$335
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:10 am -
2 stops7h 11m
Sat 9/265:38 pm -
1 stop6h 21m
Deal found 9/7![United Airlines logo]()
$354
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:10 pm -
1 stop4h 50m
Mon 11/1610:45 am -
2 stops11h 05m
Deal found 9/8![Southwest logo]()
$324
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:00 am -
1 stop4h 37m
Tue 9/155:15 pm -
1 stop6h 07m
Deal found 9/3![American Airlines logo]()
$363
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:26 pm -
1 stop3h 35m
Thu 10/2211:51 am -
1 stop4h 58m
Deal found 9/3![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/193:35 pm -
2 stops6h 00m
Fri 10/238:05 pm -
1 stop4h 10m
Deal found 9/8![Southwest logo]()
$325
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/32:12 pm -
2 stops8h 47m
Wed 10/76:25 am -
2 stops8h 14m
Deal found 9/8![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:05 am -
1 stop4h 01m
Tue 10/278:10 am -
1 stop4h 44m
Deal found 9/3![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/201:05 pm -
2 stops8h 00m
Tue 10/277:00 am -
2 stops8h 20m
Deal found 9/5![Southwest logo]()
$327
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:05 am -
1 stop6h 25m
Sun 9/208:10 am -
1 stop4h 10m
Deal found 9/3![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:00 am -
1 stop6h 50m
Wed 12/910:00 am -
1 stop4h 37m
Deal found 9/7![United Airlines logo]()
$371
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/207:30 am -
2 stops6h 51m
Sat 9/265:15 pm -
1 stop6h 07m
Deal found 9/7![American Airlines logo]()
$432
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/113:35 pm -
1 stop5h 20m
Thu 1/141:30 pm -
1 stop8h 35m
Deal found 9/3![Southwest logo]()
$336
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop5h 06m
Fri 10/235:30 am -
1 stop3h 27m
Deal found 9/3![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:00 am -
1 stop4h 02m
Wed 10/73:00 pm -
2 stops8h 41m
Deal found 9/8![United Airlines logo]()
$385
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/165:35 am -
1 stop4h 45m
Tue 2/238:20 am -
1 stop4h 35m
Deal found 9/5![Southwest logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:02 am -
1 stop5h 34m
Wed 11/255:47 pm -
1 stop6h 33m
Deal found 9/4![American Airlines logo]()
$453
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:15 am -
1 stop5h 12m
Wed 9/303:00 pm -
2 stops8h 59m
Deal found 9/3![United Airlines logo]()
$390
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/171:59 pm -
1 stop5h 02m
Wed 10/218:10 am -
1 stop4h 44m
Deal found 9/4![Delta logo]()
$357
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/293:35 pm -
2 stops7h 15m
Mon 11/26:40 am -
1 stop5h 30m
Deal found 9/6![Southwest logo]()
$340
Last-minute flights from Louisville to South CarolinaDiscover last-minute flight deals from Louisville to South Carolina. Data last updated September 8, 2026 and is based on user searches.
Discover last-minute flight deals from Louisville to South Carolina. Data last updated September 8, 2026 and is based on user searches.
This Breeze Airways deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:59 pm -
Nonstop1h 35m
Mon 9/216:10 am -
Nonstop1h 52m
Deal found 9/4![Breeze Airways logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:59 pm -
Nonstop1h 35m
Mon 10/56:10 am -
Nonstop1h 52m
Deal found 9/3![Breeze Airways logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/27:59 pm -
Nonstop1h 35m
Mon 10/56:10 am -
Nonstop1h 52m
Deal found 9/6![Breeze Airways logo]()
$117
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/32:12 pm -
1 stop5h 28m
Wed 10/73:24 pm -
1 stop8h 17m
Deal found 9/8![United Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:59 pm -
Nonstop1h 35m
Mon 10/126:10 am -
Nonstop1h 52m
Deal found 9/6![Breeze Airways logo]()
$127
This Super.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:59 pm -
Nonstop1h 35m
Mon 10/126:10 am -
Nonstop1h 52m
Deal found 9/5![Breeze Airways logo]()
$143
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
1 stop4h 07m
Wed 10/2110:52 am -
1 stop5h 57m
Deal found 9/7![Delta logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:59 pm -
Nonstop1h 35m
Mon 10/266:10 am -
Nonstop1h 52m
Deal found 9/7![Breeze Airways logo]()
$137
This Priceline deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:59 pm -
Nonstop1h 35m
Fri 10/306:10 am -
Nonstop1h 52m
Deal found 9/7![Breeze Airways logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:59 pm -
Nonstop1h 35m
Mon 11/26:10 am -
Nonstop1h 52m
Deal found 9/5![Breeze Airways logo]()
$102
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:04 am -
1 stop6h 01m
Sat 10/312:56 pm -
1 stop4h 40m
Deal found 9/7![American Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:25 am -
1 stop6h 18m
Mon 11/26:10 am -
Nonstop1h 52m
Deal found 9/7![Breeze Airways logo]()
$150
One-way flights from Louisville to South CarolinaSearch for one-way flight options from Louisville to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
Search for one-way flight options from Louisville to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:59 pm -
Nonstop1h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Breeze Airways logo]()
$54
This Breeze Airways deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:59 pm -
Nonstop1h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Breeze Airways logo]()
$74
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:30 am -
1 stop4h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Southwest logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:06 pm -
2 stops13h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Breeze Airways logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1910:25 am -
1 stop10h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![Breeze Airways logo]()
$132
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:54 pm -
1 stop22h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$139
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am -
1 stop3h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/138:54 pm -
1 stop22h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![Multiple Airlines logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:06 pm -
2 stops26h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Breeze Airways logo]()
$146
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/159:09 pm -
1 stop14h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Breeze Airways logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:02 pm -
1 stop12h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$149
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2911:10 am -
1 stop4h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![American Airlines logo]()
$158
Find flight deals from Louisville to South Carolina
Keep the following information in mind while searching for Louisville to South Carolina flight deals. Data was last updated September 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $98 (Kiwi.com) |
One-way from | $54 (Kiwi.com) |
Popular in | January |
Cheapest in | July |
Average price | $356 |
Good round-trip deal | $118 or less |
Good one-way deal | $84 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Louisville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
Use the filters below to find and compare flights from Louisville to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Fri 9/25
7:59 pm-9:34 pm
Nonstop1h 35m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$74
LouisvilleMyrtle Beach
SDF Louisville Intl - MYR Myrtle Beach Intl
SDFMYR
Louisville Intl
Wed 10/7
6:00 am-9:44 am
1 stop3h 44m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$140
LouisvilleMyrtle Beach
SDF Louisville Intl - MYR Myrtle Beach Intl
SDFMYR
Louisville Intl
Thu 10/15
9:09 pm-11:44 am
1 stop14h 35m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$148
LouisvilleSavannah
SDF Louisville Intl - SAV Savannah/Hilton Head
SDFSAV
Louisville Intl
Thu 12/31
9:30 am-12:49 pm
1 stop3h 19m
Savannah/Hilton Head
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$150
LouisvilleCharleston
SDF Louisville Intl - CHS Charleston
SDFCHS
Louisville Intl
Sat 11/7
4:46 pm-10:59 pm
1 stop6h 13m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$158
LouisvilleGreenville
SDF Louisville Intl - GSP Greenville
SDFGSP
Louisville Intl
Thu 10/1
5:15 am-9:58 am
1 stop4h 43m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$159
LouisvilleMyrtle Beach
SDF Louisville Intl - MYR Myrtle Beach Intl
SDFMYR
Louisville Intl
Tue 10/20
3:55 pm-8:10 pm
1 stop4h 15m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$170
LouisvilleMyrtle Beach
SDF Louisville Intl - MYR Myrtle Beach Intl
SDFMYR
Louisville Intl
Wed 10/21
5:45 am-9:45 am
1 stop4h 00m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$170
LouisvilleMyrtle Beach
SDF Louisville Intl - MYR Myrtle Beach Intl
SDFMYR
Louisville Intl
Sat 10/3
6:15 am-11:38 am
1 stop5h 23m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$170
LouisvilleSavannah
SDF Louisville Intl - SAV Savannah/Hilton Head
SDFSAV
Louisville Intl
Tue 10/6
10:40 am-3:20 pm
1 stop4h 40m
Savannah/Hilton Head
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$170
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Louisville to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Louisville with our price prediction graph.
SDF-CHS
SDF-CAE
SDF-GSP
SDF-MYR
SDF-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Louisville to South Carolina
SDF-USSC
SDF-CHS
SDF-CAE
SDF-GSP
SDF-MYR
What is the cheapest month to book a flight from Louisville to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Louisville to South Carolina (average of $230). Flying from Louisville to South Carolina in March is currently the most expensive (average of $410). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SDF to SC?
Find hourly flight availability from Louisville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 8, 2026.
A simple way to save on the total cost of your ticket is to fly from Louisville to South Carolina in the morning. If you’re flexible enough to do this you can expect to save up to 70% on your trip compared to booking a flight at noon.
How much does it cost to fly round-trip from Louisville to South Carolina?
Airfare is below average for this route at the moment.
Louisville to South Carolina flights typically cost between $148 and $361 in November.The cheapest round-trip price found within the last 5 days was $98 on Breeze Airways (Nov 13-Dec 7).
How far ahead should I book a flight from Louisville to South Carolina?
To ensure you get the cheapest price possible for a flight from Louisville to South Carolina, you should look to book at least 58 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 8, 2026.
Get a feel of what it's like to fly with Breeze Airways,Southwest, andDelta from Louisville to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.8
Entertainment
6.7
Comfort
8.2
Food
6.8
Overall
8.2
Boarding
8.4
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Crew
8.8
Entertainment
6.7
Comfort
8.2
Food
6.8
Overall
8.2
Boarding
8.4
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Crew
8.8
Entertainment
6.7
Comfort
8.2
Food
6.8
Overall
8.2
Boarding
8.4
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Crew
8.8
Entertainment
6.7
Comfort
8.2
Food
6.8
Overall
8.2
Boarding
8.4
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Crew
8.8
Entertainment
6.7
Comfort
8.2
Food
6.8
Overall
8.2
Boarding
8.4
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Crew
8.8
Entertainment
6.7
Comfort
8.2
Food
6.8
Overall
8.2
Boarding
8.4
Reviews
1 / 18
4.0
OkayLisa,Mar 2026
ORF - JAX
Related info for your journey
Find useful and relevant information for your journey from Louisville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Louisville to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Louisville to South Carolina by cabin class
Find flights from Louisville to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Louisville and South Carolina flights
Browse other Louisville and South Carolina flight options. Last updated on September 8, 2026.
Popular flight searches
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Louisville to South Carolina flights
Consider these flights traveling from Louisville to South Carolina.
Top 6 airlines flying from Louisville to South Carolina
Discover the top 6 airlines that operate flights from Louisville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$63 | Average$134 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$88 | Average$154 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$186 | Average$394 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$228 | Average$370 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$388 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$274 | Average$393 | FlexibilityNo cancel fee | On-time69% |