$53+ Cheap flights from South Carolina to Louisville (SDF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/18. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SDF
Oct 9 — Oct 161
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Louisville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Louisville
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Cheapest flights from South Carolina to LouisvilleExplore the most affordable flight options available from South Carolina to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
Explore the most affordable flight options available from South Carolina to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:10 am -
Nonstop1h 52m
Wed 9/237:06 pm -
2 stops13h 32m
Deal found 9/4![Breeze Airways logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:10 am -
Nonstop1h 52m
Mon 9/287:59 pm -
Nonstop1h 35m
Deal found 9/7![Breeze Airways logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:10 am -
Nonstop1h 52m
Sun 10/259:09 pm -
2 stops23h 52m
Deal found 9/6![Breeze Airways logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:10 am -
Nonstop1h 52m
Mon 9/147:59 pm -
Nonstop1h 35m
Deal found 9/6![Breeze Airways logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/239:03 pm -
2 stops23h 26m
Fri 9/257:59 pm -
Nonstop1h 35m
Deal found 9/5![Breeze Airways logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
2 stops14h 31m
Fri 10/167:59 pm -
Nonstop1h 35m
Deal found 9/4![Breeze Airways logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:10 am -
Nonstop1h 52m
Sun 9/209:09 pm -
2 stops23h 47m
Deal found 9/6![Breeze Airways logo]()
$277
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/310:23 am -
1 stop6h 36m
Sat 10/105:04 am -
1 stop3h 33m
Deal found 9/8![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:10 am -
Nonstop1h 52m
Wed 10/149:11 pm -
2 stops35h 37m
Deal found 9/4![Multiple Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:35 pm -
1 stop4h 40m
Mon 11/25:35 pm -
1 stop6h 15m
Deal found 9/8![Southwest logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:10 am -
Nonstop1h 52m
Wed 10/149:11 pm -
2 stops35h 37m
Deal found 9/5![Breeze Airways logo]()
$281
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:50 am -
2 stops7h 47m
Mon 11/25:10 am -
1 stop5h 13m
Deal found 9/8![United Airlines logo]()
$284
Best flights from South Carolina to LouisvilleDiscover carefully curated flight deals from South Carolina to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
Discover carefully curated flight deals from South Carolina to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:35 pm -
1 stop4h 40m
Mon 11/25:35 pm -
1 stop6h 15m
Deal found 9/8![Southwest logo]()
$279
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:24 pm -
1 stop8h 17m
Mon 10/195:15 am -
1 stop5h 45m
Deal found 9/7![United Airlines logo]()
$299
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:36 pm -
1 stop3h 23m
Mon 10/57:55 pm -
1 stop4h 00m
Deal found 9/8![Delta logo]()
$300
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:18 am -
1 stop3h 46m
Tue 9/295:48 pm -
1 stop5h 27m
Deal found 9/9![American Airlines logo]()
$314
This Breeze Airways deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:10 am -
Nonstop1h 52m
Mon 9/2810:25 am -
1 stop6h 18m
Deal found 9/7![Breeze Airways logo]()
$324
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:10 am -
Nonstop1h 52m
Mon 9/1411:15 am -
2 stops25h 16m
Deal found 9/6![Multiple Airlines logo]()
$453
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/27:33 pm -
1 stop3h 49m
Sun 10/46:00 am -
1 stop4h 19m
Deal found 9/4![American Airlines logo]()
$314
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/182:52 pm -
2 stops8h 38m
Sun 11/2210:37 am -
2 stops8h 31m
Deal found 9/7![United Airlines logo]()
$320
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:59 pm -
1 stop5h 10m
Sun 12/67:00 am -
1 stop6h 33m
Deal found 9/3![Delta logo]()
$328
This Breeze Airways deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:10 am -
Nonstop1h 52m
Mon 9/1410:25 am -
1 stop6h 18m
Deal found 9/6![Breeze Airways logo]()
$337
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:35 pm -
1 stop4h 35m
Mon 10/56:15 pm -
1 stop3h 20m
Deal found 9/6![Southwest logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:50 am -
1 stop7h 13m
Sat 10/315:10 am -
1 stop4h 41m
Deal found 9/8![United Airlines logo]()
$327
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:35 pm -
2 stops7h 00m
Tue 11/37:20 am -
1 stop5h 55m
Deal found 9/7![Southwest logo]()
$344
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:45 am -
1 stop6h 09m
Tue 10/137:05 am -
1 stop4h 01m
Deal found 9/5![Delta logo]()
$357
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/212:50 pm -
1 stop4h 24m
Sun 10/116:00 am -
1 stop4h 25m
Deal found 9/5![American Airlines logo]()
$360
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2610:38 am -
2 stops8h 46m
Tue 9/296:15 am -
1 stop5h 23m
Deal found 9/4![United Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:25 am -
2 stops8h 30m
Tue 11/35:40 am -
2 stops8h 30m
Deal found 9/7![Southwest logo]()
$346
This FlightHub deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:10 am -
Nonstop1h 52m
Sun 12/69:09 pm -
1 stop16h 41m
Deal found 9/4![Breeze Airways logo]()
$406
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:46 pm -
1 stop6h 25m
Tue 10/62:12 pm -
2 stops8h 47m
Deal found 9/4![United Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:35 pm -
1 stop4h 24m
Thu 9/249:45 am -
1 stop3h 22m
Deal found 9/8![Delta logo]()
$412
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/108:27 am -
1 stop4h 48m
Mon 10/196:00 am -
2 stops8h 16m
Deal found 9/7![United Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/910:40 am -
2 stops10h 30m
Mon 10/126:15 pm -
1 stop4h 35m
Deal found 9/3![Southwest logo]()
$383
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/289:50 am -
1 stop4h 57m
Thu 10/296:00 am -
1 stop5h 00m
Deal found 9/3![United Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:10 pm -
1 stop4h 55m
Fri 10/233:35 pm -
1 stop6h 15m
Deal found 9/4![Southwest logo]()
$385
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:05 am -
1 stop4h 51m
Sun 11/296:00 am -
1 stop3h 47m
Deal found 9/6![Delta logo]()
$437
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/48:35 pm -
1 stop3h 44m
Sun 12/66:00 am -
2 stops6h 16m
Deal found 9/3![American Airlines logo]()
$506
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:05 pm -
1 stop4h 10m
Tue 10/205:45 am -
1 stop4h 10m
Deal found 9/7![Southwest logo]()
$385
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2712:21 pm -
1 stop8h 12m
Sat 10/315:40 am -
1 stop6h 01m
Deal found 9/8![United Airlines logo]()
$351
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:00 am -
1 stop6h 20m
Sun 9/136:00 am -
1 stop4h 12m
Deal found 9/3![Delta logo]()
$465
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/310:38 am -
2 stops9h 53m
Sat 10/1011:13 am -
1 stop6h 59m
Deal found 9/8![United Airlines logo]()
$354
Last-minute flights from South Carolina to LouisvilleDiscover last-minute flight deals from South Carolina to Louisville. Data last updated September 9, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Louisville. Data last updated September 9, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:10 am -
Nonstop1h 52m
Mon 9/147:59 pm -
Nonstop1h 35m
Deal found 9/6![Breeze Airways logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:10 am -
Nonstop1h 52m
Sun 9/209:09 pm -
2 stops23h 47m
Deal found 9/6![Breeze Airways logo]()
$277
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:10 am -
Nonstop1h 52m
Wed 9/237:06 pm -
2 stops13h 32m
Deal found 9/4![Breeze Airways logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/239:03 pm -
2 stops23h 26m
Fri 9/257:59 pm -
Nonstop1h 35m
Deal found 9/5![Breeze Airways logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:10 am -
Nonstop1h 52m
Mon 9/287:59 pm -
Nonstop1h 35m
Deal found 9/7![Breeze Airways logo]()
$247
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/310:23 am -
1 stop6h 36m
Sat 10/105:04 am -
1 stop3h 33m
Deal found 9/8![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:10 am -
Nonstop1h 52m
Wed 10/149:11 pm -
2 stops35h 37m
Deal found 9/4![Multiple Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:10 am -
Nonstop1h 52m
Wed 10/149:11 pm -
2 stops35h 37m
Deal found 9/5![Breeze Airways logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
2 stops14h 31m
Fri 10/167:59 pm -
Nonstop1h 35m
Deal found 9/4![Breeze Airways logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:10 am -
Nonstop1h 52m
Sun 10/259:09 pm -
2 stops23h 52m
Deal found 9/6![Breeze Airways logo]()
$254
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:35 pm -
1 stop4h 40m
Mon 11/25:35 pm -
1 stop6h 15m
Deal found 9/8![Southwest logo]()
$279
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:50 am -
2 stops7h 47m
Mon 11/25:10 am -
1 stop5h 13m
Deal found 9/8![United Airlines logo]()
$284
One-way flights from South Carolina to LouisvilleSearch for one-way flight options from South Carolina to Louisville. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
Search for one-way flight options from South Carolina to Louisville. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:10 am -
Nonstop1h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Breeze Airways logo]()
$53
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:10 am -
Nonstop1h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Breeze Airways logo]()
$63
This Breeze Airways deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:10 am -
Nonstop1h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Breeze Airways logo]()
$64
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:10 am -
Nonstop1h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Breeze Airways logo]()
$73
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:42 am -
1 stop23h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Breeze Airways logo]()
$129
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:41 pm -
1 stop3h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![American Airlines logo]()
$129
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:25 pm -
2 stops9h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Southwest logo]()
$134
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:19 pm -
1 stop4h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Delta logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/110:00 am -
2 stops30h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
2 stops14h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Breeze Airways logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/69:40 pm -
2 stops22h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/248:40 am -
2 stops11h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Breeze Airways logo]()
$157
Find flight deals from South Carolina to Louisville
Keep the following information in mind while searching for South Carolina to Louisville flight deals. Data was last updated September 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $182 (Kiwi.com) |
One-way from | $53 (Kiwi.com) |
Popular in | September |
Cheapest in | July |
Average price | $473 |
Good round-trip deal | $98 or less |
Good one-way deal | $204 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
Use the filters below to find and compare flights from South Carolina to Louisville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Fri 10/23
6:10 am-8:02 am
Nonstop1h 52m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$63
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Fri 10/30
6:10 am-8:02 am
Nonstop1h 52m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$64
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Fri 9/25
6:10 am-8:02 am
Nonstop1h 52m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$73
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Mon 9/21
6:00 am-10:40 am
1 stop4h 40m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$129
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Fri 10/16
8:05 pm-12:15 am
1 stop4h 10m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$129
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Fri 10/30
3:37 pm-9:35 pm
1 stop5h 58m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$129
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Fri 9/11
6:10 am-8:02 am
Nonstop1h 52m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$133
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Fri 10/30
1:25 pm-10:35 pm
2 stops9h 10m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$134
GreenvilleLouisville
GSP Greenville - SDF Louisville Intl
GSPSDF
Greenville
Mon 11/9
7:19 pm-12:10 am
1 stop4h 51m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$137
SavannahLouisville
SAV Savannah/Hilton Head - SDF Louisville Intl
SAVSDF
Savannah/Hilton Head
Thu 9/24
8:40 am-8:29 pm
2 stops11h 49m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$157
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Louisville
Have a flexible travel schedule? Discover the best time to fly to Louisville from South Carolina with our price prediction graph.
SAV-SDF
CAE-SDF
CHS-SDF
MYR-SDF
GSP-SDF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Louisville
USSC-SDF
SAV-SDF
CAE-SDF
CHS-SDF
MYR-SDF
What is the cheapest month to book a flight from South Carolina to Louisville?
Currently, November is the cheapest month in which you can book a flight from South Carolina to Louisville (average of $289). Flying from South Carolina to Louisville in December is currently the most expensive (average of $454). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to SDF?
Find hourly flight availability from South Carolina to Louisville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 9, 2026.
When flying from South Carolina to Louisville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from South Carolina to Louisville?
Airfare is typical for this route at the moment.
South Carolina to Louisville flights typically cost between $157 and $343 in September.The cheapest round-trip price found within the last 5 days was $182 on Breeze Airways (Sep 21-Sep 23).
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Louisville?
Book flights to Louisville if you plan to visit one of these locationsShepherdsville
Elizabethtown
Jeffersonville
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for South Carolina to Louisville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Louisville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Louisville by cabin class
Find flights from South Carolina to Louisville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Louisville
Explore flights to Louisville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 9, 2026.
South Carolina and Louisville flights
Browse other South Carolina and Louisville flight options. Last updated on September 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Louisville flights
Consider these flights traveling from South Carolina to Louisville.
Top 3 airlines flying from South Carolina to Louisville
Discover the top 3 airlines that operate flights from South Carolina to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$93 | Average$167 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$206 | Average$362 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$238 | Average$375 | FlexibilityNo cancel fee | On-time71% |