$102+ Cheap flights from South Carolina to Louisville (SDF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/30. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SDF
Dec 4 — Dec 111
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Louisville with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to LouisvilleExplore the most affordable flight options available from South Carolina to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
Explore the most affordable flight options available from South Carolina to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:10 am -
Nonstop1h 52m
Mon 12/147:59 pm -
Nonstop1h 35m
Deal found 11/1![Breeze Airways logo]()
$107
This Breeze Airways deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:10 am -
Nonstop1h 52m
Fri 11/207:59 pm -
Nonstop1h 35m
Deal found 11/2![Breeze Airways logo]()
$123
This Breeze Airways deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/286:10 am -
Nonstop1h 52m
Mon 1/410:25 am -
1 stop6h 18m
Deal found 10/31![Breeze Airways logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/276:10 am -
Nonstop1h 52m
Mon 11/307:59 pm -
Nonstop1h 35m
Deal found 11/1![Breeze Airways logo]()
$173
This Breeze Airways deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:10 am -
Nonstop1h 52m
Mon 11/97:59 pm -
Nonstop1h 35m
Deal found 11/1![Breeze Airways logo]()
$218
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/288:28 pm -
1 stop3h 40m
Fri 1/12:54 pm -
1 stop7h 02m
Deal found 11/1![American Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:59 pm -
1 stop5h 09m
Sun 12/67:05 am -
1 stop6h 28m
Deal found 11/2![Delta logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:47 pm -
1 stop23h 42m
Sun 11/226:17 pm -
1 stop19h 26m
Deal found 11/3![Multiple Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/43:25 pm -
1 stop6h 50m
Sun 12/612:05 pm -
2 stops8h 15m
Deal found 11/2![Southwest logo]()
$318
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/145:34 pm -
1 stop6h 15m
Tue 12/1510:25 am -
1 stop6h 28m
Deal found 11/3![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:37 pm -
1 stop4h 53m
Sat 11/212:11 pm -
1 stop4h 57m
Deal found 11/4![United Airlines logo]()
$387
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1112:22 pm -
1 stop5h 15m
Wed 11/182:11 pm -
1 stop4h 57m
Deal found 11/2![United Airlines logo]()
$389
Best flights from South Carolina to LouisvilleDiscover carefully curated flight deals from South Carolina to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
Discover carefully curated flight deals from South Carolina to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
This Breeze Airways deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:10 am -
Nonstop1h 52m
Fri 11/207:59 pm -
Nonstop1h 35m
Deal found 11/2![Breeze Airways logo]()
$123
This Southwest deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/287:55 pm -
1 stop4h 35m
Mon 1/412:05 pm -
2 stops8h 55m
Deal found 10/31![Southwest logo]()
$242
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/110:23 am -
2 stops9h 12m
Fri 12/47:10 am -
2 stops8h 22m
Deal found 11/1![United Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/316:12 am -
1 stop6h 06m
Sun 2/76:00 am -
1 stop3h 44m
Deal found 10/30![American Airlines logo]()
$347
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/297:59 pm -
1 stop4h 24m
Sat 1/26:56 pm -
1 stop3h 31m
Deal found 10/31![Delta logo]()
$370
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:40 am -
2 stops8h 55m
Fri 11/278:45 am -
1 stop7h 05m
Deal found 11/1![Southwest logo]()
$357
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/145:34 pm -
1 stop6h 15m
Tue 12/1510:25 am -
1 stop6h 28m
Deal found 11/3![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2811:27 am -
1 stop7h 47m
Mon 2/17:00 am -
2 stops10h 48m
Deal found 11/1![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:47 pm -
1 stop6h 33m
Mon 11/236:30 am -
1 stop4h 06m
Deal found 11/4![American Airlines logo]()
$425
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/117:40 am -
2 stops8h 55m
Mon 12/1412:10 pm -
2 stops7h 25m
Deal found 11/1![Southwest logo]()
$393
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:29 pm -
1 stop7h 01m
Sat 11/287:00 am -
1 stop6h 56m
Deal found 11/2![United Airlines logo]()
$380
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:40 am -
1 stop6h 16m
Sun 11/297:05 am -
1 stop4h 02m
Deal found 11/2![Delta logo]()
$468
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/227:05 pm -
1 stop3h 56m
Sat 12/265:00 am -
1 stop5h 38m
Deal found 11/3![American Airlines logo]()
$436
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/288:05 pm -
1 stop4h 25m
Fri 1/18:50 am -
2 stops9h 20m
Deal found 11/1![Southwest logo]()
$401
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1510:42 am -
1 stop23h 03m
Thu 11/199:09 pm -
1 stop23h 03m
Deal found 10/31![Breeze Airways logo]()
$490
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:37 pm -
1 stop4h 53m
Sat 11/212:11 pm -
1 stop4h 57m
Deal found 11/4![United Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:21 pm -
1 stop4h 25m
Sat 11/2111:12 am -
2 stops6h 53m
Deal found 11/4![American Airlines logo]()
$457
This Southwest deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/306:30 pm -
1 stop3h 15m
Sun 5/25:30 am -
1 stop4h 20m
Deal found 11/4![Southwest logo]()
$424
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:37 pm -
1 stop4h 53m
Mon 11/92:11 pm -
1 stop4h 57m
Deal found 11/3![United Airlines logo]()
$420
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:54 pm -
1 stop6h 25m
Mon 11/166:04 am -
1 stop5h 49m
Deal found 11/2![American Airlines logo]()
$487
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:00 am -
1 stop5h 56m
Wed 11/188:05 am -
1 stop5h 28m
Deal found 11/3![Delta logo]()
$598
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/32:57 pm -
1 stop4h 38m
Thu 12/1010:25 am -
2 stops13h 34m
Deal found 11/3![United Airlines logo]()
$437
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/237:05 pm -
1 stop5h 03m
Sat 12/265:00 am -
1 stop5h 38m
Deal found 11/3![American Airlines logo]()
$521
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1710:45 am -
2 stops11h 30m
Sat 11/216:30 am -
2 stops12h 00m
Deal found 11/2![Southwest logo]()
$525
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/316:29 pm -
1 stop5h 11m
Sun 2/77:00 am -
2 stops10h 48m
Deal found 10/30![United Airlines logo]()
$442
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/710:16 am -
2 stops12h 14m
Sun 11/86:00 am -
1 stop3h 59m
Deal found 11/3![United Airlines logo]()
$450
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/163:25 pm -
1 stop6h 50m
Fri 11/207:05 am -
2 stops11h 50m
Deal found 11/1![Southwest logo]()
$563
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:09 am -
1 stop6h 06m
Mon 11/236:11 pm -
1 stop5h 43m
Deal found 11/4![American Airlines logo]()
$565
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:16 am -
1 stop4h 31m
Mon 11/232:10 pm -
1 stop6h 52m
Deal found 11/4![United Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:24 am -
1 stop5h 03m
Sat 11/216:02 am -
2 stops8h 07m
Deal found 11/1![American Airlines logo]()
$605
Last-minute flights from South Carolina to LouisvilleDiscover last-minute flight deals from South Carolina to Louisville. Data last updated November 4, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Louisville. Data last updated November 4, 2026 and is based on user searches.
This Breeze Airways deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:10 am -
Nonstop1h 52m
Mon 11/97:59 pm -
Nonstop1h 35m
Deal found 11/1![Breeze Airways logo]()
$218
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1112:22 pm -
1 stop5h 15m
Wed 11/182:11 pm -
1 stop4h 57m
Deal found 11/2![United Airlines logo]()
$389
This Breeze Airways deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:10 am -
Nonstop1h 52m
Fri 11/207:59 pm -
Nonstop1h 35m
Deal found 11/2![Breeze Airways logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:47 pm -
1 stop23h 42m
Sun 11/226:17 pm -
1 stop19h 26m
Deal found 11/3![Multiple Airlines logo]()
$317
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:37 pm -
1 stop4h 53m
Sat 11/212:11 pm -
1 stop4h 57m
Deal found 11/4![United Airlines logo]()
$387
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/276:10 am -
Nonstop1h 52m
Mon 11/307:59 pm -
Nonstop1h 35m
Deal found 11/1![Breeze Airways logo]()
$173
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:59 pm -
1 stop5h 09m
Sun 12/67:05 am -
1 stop6h 28m
Deal found 11/2![Delta logo]()
$313
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/43:25 pm -
1 stop6h 50m
Sun 12/612:05 pm -
2 stops8h 15m
Deal found 11/2![Southwest logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:10 am -
Nonstop1h 52m
Mon 12/147:59 pm -
Nonstop1h 35m
Deal found 11/1![Breeze Airways logo]()
$107
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/145:34 pm -
1 stop6h 15m
Tue 12/1510:25 am -
1 stop6h 28m
Deal found 11/3![United Airlines logo]()
$369
This Breeze Airways deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/286:10 am -
Nonstop1h 52m
Mon 1/410:25 am -
1 stop6h 18m
Deal found 10/31![Breeze Airways logo]()
$145
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/288:28 pm -
1 stop3h 40m
Fri 1/12:54 pm -
1 stop7h 02m
Deal found 11/1![American Airlines logo]()
$279
One-way flights from South Carolina to LouisvilleSearch for one-way flight options from South Carolina to Louisville. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
Search for one-way flight options from South Carolina to Louisville. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:10 am -
Nonstop1h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Breeze Airways logo]()
$102
This Super.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:10 am -
Nonstop1h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Breeze Airways logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:00 am -
1 stop13h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Breeze Airways logo]()
$114
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:04 pm -
1 stop3h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Delta logo]()
$119
This Breeze Airways deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:10 am -
Nonstop1h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Breeze Airways logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/178:43 am -
1 stop24h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Allegiant Air logo]()
$138
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/226:00 am -
1 stop5h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![American Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1710:12 am -
2 stops22h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Multiple Airlines logo]()
$146
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/188:06 am -
1 stop3h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Delta logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/208:43 am -
1 stop24h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Allegiant Air logo]()
$156
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/244:10 pm -
1 stop5h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![American Airlines logo]()
$158
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/212:53 pm -
2 stops27h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Multiple Airlines logo]()
$160
Find flight deals from South Carolina to Louisville
Keep the following information in mind while searching for South Carolina to Louisville flight deals. Data was last updated November 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $107 (Kiwi.com) |
One-way from | $102 (Kiwi.com) |
Good round-trip deal | $230 or less |
Good one-way deal | $191 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
Use the filters below to find and compare flights from South Carolina to Louisville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Wed 12/2
7:00 am-8:47 pm
1 stop13h 47m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$114
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Mon 11/30
7:04 pm-10:53 pm
1 stop3h 49m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$119
Quickest round-trip
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Mon 11/16
6:10 am-8:02 am
Nonstop1h 52m
Louisville Intl
Fri 11/20
7:59 pm-9:34 pm
Nonstop1h 35m
$123
GreenvilleLouisville
GSP Greenville - SDF Louisville Intl
GSPSDF
Greenville
Mon 12/21
8:52 pm-6:08 pm
1 stop21h 16m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$146
GreenvilleLouisville
GSP Greenville - SDF Louisville Intl
GSPSDF
Greenville
Sat 12/19
7:41 pm-12:23 am
1 stop4h 42m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$149
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Thu 11/26
7:00 am-12:43 pm
1 stop5h 43m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$158
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Wed 12/9
2:57 pm-11:59 pm
2 stops9h 02m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$163
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Wed 11/25
1:05 pm-12:55 am
2 stops11h 50m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$234
CharlestonLouisville
CHS Charleston - SDF Louisville Intl
CHSSDF
Charleston
Mon 12/28
7:55 pm-12:30 am
1 stop4h 35m
Louisville Intl
Mon 1/4
12:05 pm-9:00 pm
2 stops8h 55m
$242
Hilton Head IslandLouisville
HHH Hilton Head Island - SDF Louisville Intl
HHHSDF
Hilton Head Island
Thu 4/1
3:05 pm-8:14 pm
1 stop5h 09m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$246
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Louisville
Have a flexible travel schedule? Discover the best time to fly to Louisville from South Carolina with our price prediction graph.
CHS-SDF
GSP-SDF
MYR-SDF
HHH-SDF
CAE-SDF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Louisville
USSC-SDF
CHS-SDF
GSP-SDF
MYR-SDF
HHH-SDF
What is the cheapest month to book a flight from South Carolina to Louisville?
Currently, February is the cheapest month in which you can book a flight from South Carolina to Louisville (average of $316). Flying from South Carolina to Louisville in April is currently the most expensive (average of $444). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to SDF?
Find hourly flight availability from South Carolina to Louisville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 4, 2026.
When flying from South Carolina to Louisville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from South Carolina to Louisville?
Airfare is below average for this route at the moment.
South Carolina to Louisville flights typically cost between $254 and $360 in December.The cheapest round-trip price found within the last 5 days was $107 on Breeze Airways (Dec 11-Dec 14).
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Louisville?
Book flights to Louisville if you plan to visit one of these locationsShepherdsville
Elizabethtown
Jeffersonville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for South Carolina to Louisville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Louisville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Louisville by cabin class
Find flights from South Carolina to Louisville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Louisville
Explore flights to Louisville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 4, 2026.
South Carolina and Louisville flights
Browse other South Carolina and Louisville flight options. Last updated on November 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Louisville flights
Consider these flights traveling from South Carolina to Louisville.
Top 3 airlines flying from South Carolina to Louisville
Discover the top 3 airlines that operate flights from South Carolina to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$93 | Average$178 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$206 | Average$382 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$237 | Average$424 | FlexibilityNo cancel fee | On-time71% |