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South America

$331+ Cheap flights from Panama City, FL (ECP) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/16. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — BOG
Jun 23 — Jun 301
Mon 6/23
Mon 6/30
1 adult, Economy
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Cheap flight deals from Panama City to South America

Keep the following information in mind while searching for Panama City to South America flight deals. Data was last updated June 18, 2025.

Round-trip from

$513
(Delta)

One-way from

$331
(American Airlines)
From Panama City NW Florida Beaches to South America
Search Deals
One-way flight from Panama City NW Florida Beaches to South America
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Find flight deals from Panama City to South America

Cheapest flights from Panama City to South America
Explore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2025.

This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/66:00 amECP - BOG
1 stop13h 15mDelta
Fri 3/65:00 amBOG - ECP
2 stops18h 42mDelta
Deal found 6/16$513
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:30 amECP - BOG
1 stop12h 50mUnited Airlines
Sun 9/288:30 amBOG - ECP
1 stop13h 18mUnited Airlines
Deal found 6/17$523
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/611:34 amECP - BOG
1 stop10h 27mAmerican Airlines
Thu 3/512:45 amBOG - ECP
1 stop14h 17mAmerican Airlines
Deal found 6/16$535
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/16:30 amECP - GYE
2 stops28h 46mUnited Airlines
Fri 8/88:30 amGYE - ECP
2 stops25h 26mUnited Airlines
Deal found 6/16$607
This United deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/226:30 amECP - BOG
2 stops17h 09mMultiple Airlines
Tue 6/248:30 amBOG - ECP
2 stops28h 36mMultiple Airlines
Deal found 6/18$840
This United deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2711:10 amECP - CUZ
2 stops23h 50mMultiple Airlines
Wed 9/312:15 pmCUZ - ECP
2 stops21h 39mMultiple Airlines
Deal found 6/18$1,236
This United deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/208:55 amECP - LPB
2 stops16h 15mMultiple Airlines
Sat 6/213:20 amLPB - ECP
2 stops38h 00mMultiple Airlines
Deal found 6/16$1,258
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2710:18 amECP - CUZ
3 stops21h 06mAmerican Airlines
Wed 9/34:27 pmCUZ - ECP
3 stops21h 31mAmerican Airlines
Deal found 6/18$2,982

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 18, 2025.
Use the filters below to find and compare flights from Panama City to South America that are best for you.

Fly from

Panama City

Fly to

South America

Route

Depart

Return

Price

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Mon 10/6

6:00 am-7:15 pm

1 stop13h 15m

Bogotá El Dorado

Fri 3/6

5:00 am-10:42 pm

2 stops18h 42m

$513

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Thu 9/25

11:10 am-7:20 pm

1 stop8h 10m

Bogotá El Dorado

Sat 9/27

12:14 am-9:51 am

1 stop9h 37m

$523

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Mon 10/6

11:34 am-10:01 pm

1 stop10h 27m

Bogotá El Dorado

Thu 3/5

12:45 am-2:02 pm

1 stop14h 17m

$535

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Fri 8/1

6:30 am-11:16 am

2 stops28h 46m

Guayaquil Jose Joaquin de Olmedo

Fri 8/8

8:30 am-9:56 am

2 stops25h 26m

$607

Panama CityCusco

ECP - CUZ

ECPCUZ

Panama City NW Florida Beaches

Wed 8/27

11:10 am-11:00 am

2 stops23h 50m

Cusco Velazco Astete

Wed 9/3

12:15 pm-9:54 am

2 stops21h 39m

$1,236

Panama CityCusco

ECP - CUZ

ECPCUZ

Panama City NW Florida Beaches

Wed 8/27

10:18 am-7:24 am

3 stops21h 06m

Cusco Velazco Astete

Wed 9/3

4:27 pm-1:58 pm

3 stops21h 31m

$2,982

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Wed 7/16

9:47 am-10:30 pm

1 stop12h 43m

$331

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Sat 7/12

6:30 am-7:20 pm

1 stop12h 50m

$341

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Thu 8/28

11:10 am-11:20 pm

2 stops36h 10m

$373

Panama CityBogotá

ECP - BOG

ECPBOG

Panama City NW Florida Beaches

Sat 7/12

6:00 am-8:55 pm

3 stops14h 55m

$862

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/16

Best time to book a flight from Panama City to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South America

What is the cheapest month to book a flight from Panama City, Florida to South America?

Currently, May is the cheapest month in which you can book a flight from Panama City, Florida to South America (average of $359). Flying from Panama City, Florida to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SA?

Find hourly flight availability from Panama City to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 18, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City, Florida to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated June 18, 2025.
Delta
8.0
Very good
7,964 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Overall

8.0

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,964 reviews
Delta
8.0
Very good
7,964 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Overall

8.0

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
8,810 reviews
Delta
8.0
Very good
7,964 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Overall

8.0

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,964 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Overall

8.0

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South America?

    Located just 16.0 mi from the city center, Panama City NW Florida Beaches (ECP) is the airport most travelers will use when flying to South America from Panama City.

  • What are the most popular routes from Panama City, Florida to South America?

    The most popular flight routes from Panama City, Florida to South America are Panama City NW Florida Beaches - Bogotá El Dorado, Panama City NW Florida Beaches - Cusco Velazco Astete and Panama City NW Florida Beaches - Guayaquil Jose Joaquin de Olmedo.

  • Can I find deals for flights from Panama City to South America that include hotel bookings?

    Yes. In addition to deals on Panama City to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South America.

  • Can I find deals for business class flights from Panama City to South America?

    Yes. Cheapflights offers flight deals from Panama City to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to South America?

    Currently, May is the cheapest month in which you can book a flight from Panama City, Florida to South America (average of $359). Flying from Panama City, Florida to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Panama City to South America

Discover the top 2 airlines that operate flights from Panama City to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$448Average$704FlexibilityNo cancel feeOn-time69%
DeltaCheapest$479Average$636FlexibilityNo cancel feeOn-timeN/A

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