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$125+ Cheap flights from Myrtle Beach (MYR) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BOG
Feb 14 — Feb 211
Sat 2/14
Sat 2/21
1 adult, Economy
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Cheap flight deals from Myrtle Beach to South America

Keep the following information in mind while searching for Myrtle Beach to South America flight deals. Data was last updated January 15, 2026.

Most accurate provider

AranGrant
2 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$309
(Kiwi.com)

One-way from

$125
(Kiwi.com)
Provider with most accurate pricing for Myrtle Beach Intl-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Sao Paulo (SAO) flights.
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From Myrtle Beach Intl to South America
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One-way flight from Myrtle Beach Intl to South America
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Find flight deals from Myrtle Beach to South America

Cheapest flights from Myrtle Beach to South America
Explore the most affordable flight options available from Myrtle Beach to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 15, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/58:15 pm
MYR
-
GYE
1 stop28h 06m
Spirit Airlines
Mon 2/91:26 am
GYE
-
MYR
1 stop17h 44m
Spirit Airlines
Deal found 1/13$309
This FlightHub deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/199:09 am
MYR
-
LIM
1 stop13h 26m
Spirit Airlines
Mon 2/2311:30 pm
LIM
-
MYR
2 stops12h 14m
Spirit Airlines
Deal found 1/14$365
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/258:15 pm
MYR
-
CTG
1 stop17h 00m
Spirit Airlines
Fri 1/302:21 pm
CTG
-
MYR
1 stop28h 59m
Spirit Airlines
Deal found 1/14$388
This KAYAK deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/318:15 pm
MYR
-
CLO
1 stop18h 00m
Spirit Airlines
Wed 2/113:22 pm
CLO
-
MYR
1 stop16h 51m
Spirit Airlines
Deal found 1/14$399
This KAYAK deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/318:15 pm
MYR
-
CLO
1 stop18h 00m
Spirit Airlines
Tue 2/103:22 pm
CLO
-
MYR
1 stop27h 48m
Spirit Airlines
Deal found 1/14$407
This Kiwi.com deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/149:09 am
MYR
-
BOG
1 stop29h 01m
Spirit Airlines
Sat 2/213:06 pm
BOG
-
MYR
1 stop17h 07m
Spirit Airlines
Deal found 1/15$410
This Kiwi.com deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/149:09 am
MYR
-
BOG
1 stop29h 01m
Multiple Airlines
Sat 2/215:15 pm
BOG
-
MYR
2 stops38h 58m
Multiple Airlines
Deal found 1/15$412
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/308:15 pm
MYR
-
CLO
1 stop18h 00m
Spirit Airlines
Tue 2/103:22 pm
CLO
-
MYR
1 stop27h 48m
Spirit Airlines
Deal found 1/14$420
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3110:00 am
MYR
-
CLO
2 stops28h 15m
Spirit Airlines
Thu 2/123:22 pm
CLO
-
MYR
1 stop16h 51m
Spirit Airlines
Deal found 1/14$423
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/308:15 pm
MYR
-
CLO
1 stop18h 00m
Spirit Airlines
Thu 2/123:22 pm
CLO
-
MYR
1 stop16h 51m
Spirit Airlines
Deal found 1/14$424
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/298:15 pm
MYR
-
CLO
1 stop18h 00m
Spirit Airlines
Thu 2/123:22 pm
CLO
-
MYR
1 stop16h 51m
Spirit Airlines
Deal found 1/14$428
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/298:15 pm
MYR
-
CLO
1 stop18h 00m
Spirit Airlines
Tue 2/103:22 pm
CLO
-
MYR
2 stops23h 20m
Spirit Airlines
Deal found 1/14$435

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from Myrtle Beach to South America that are best for you.

Fly from

Myrtle Beach

Fly to

South America

Route

Depart

Return

Price

Myrtle BeachLima

MYR - LIM

MYRLIM

Myrtle Beach Intl

Thu 2/19

9:09 am-10:35 pm

1 stop13h 26m

Lima J Chavez Intl

Mon 2/23

11:30 pm-11:44 am

2 stops12h 14m

$365

Myrtle BeachCartagena

MYR - CTG

MYRCTG

Myrtle Beach Intl

Sun 1/25

8:15 pm-1:15 pm

1 stop17h 00m

Cartagena Rafael Nunez

Fri 1/30

2:21 pm-7:20 pm

1 stop28h 59m

$388

Myrtle BeachCali

MYR - CLO

MYRCLO

Myrtle Beach Intl

Sat 1/31

8:15 pm-2:15 pm

1 stop18h 00m

Cali Alfonso B. Aragon Intl

Tue 2/10

3:22 pm-7:10 pm

1 stop27h 48m

$407

Myrtle BeachBogotá

MYR - BOG

MYRBOG

Myrtle Beach Intl

Sat 2/14

9:09 am-2:10 pm

1 stop29h 01m

Bogotá El Dorado

Sat 2/21

3:06 pm-8:13 am

1 stop17h 07m

$410

Myrtle BeachBogotá

MYR - BOG

MYRBOG

Myrtle Beach Intl

Sat 2/14

9:09 am-2:10 pm

1 stop29h 01m

Bogotá El Dorado

Sat 2/21

5:15 pm-8:13 am

2 stops38h 58m

$412

Myrtle BeachCali

MYR - CLO

MYRCLO

Myrtle Beach Intl

Sat 1/31

10:00 am-2:15 pm

2 stops28h 15m

Cali Alfonso B. Aragon Intl

Thu 2/12

3:22 pm-8:13 am

1 stop16h 51m

$423

Myrtle BeachCali

MYR - CLO

MYRCLO

Myrtle Beach Intl

Thu 1/29

8:15 pm-2:15 pm

1 stop18h 00m

Cali Alfonso B. Aragon Intl

Tue 2/10

3:22 pm-7:10 pm

1 stop27h 48m

$424

Myrtle BeachCali

MYR - CLO

MYRCLO

Myrtle Beach Intl

Thu 1/29

8:15 pm-2:15 pm

1 stop18h 00m

Cali Alfonso B. Aragon Intl

Thu 2/12

3:22 pm-8:13 am

1 stop16h 51m

$428

Myrtle BeachCali

MYR - CLO

MYRCLO

Myrtle Beach Intl

Sat 1/31

1:07 pm-2:15 pm

2 stops25h 08m

Cali Alfonso B. Aragon Intl

Wed 2/11

3:22 pm-8:13 am

1 stop16h 51m

$442

Myrtle BeachCali

MYR - CLO

MYRCLO

Myrtle Beach Intl

Fri 1/30

8:15 pm-8:56 am

2 stops36h 41m

Cali Alfonso B. Aragon Intl

Wed 2/11

3:22 pm-8:13 am

1 stop16h 51m

$451

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/13

Showing 1-10 of 49 results
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Best time to book a flight from Myrtle Beach to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to South America

What is the cheapest month to book a flight from Myrtle Beach to South America?

Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to South America (average of $176). Flying from Myrtle Beach to South America in October is currently the most expensive (average of $647). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated January 15, 2026.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and Spirit Airlines from Myrtle Beach to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,051 reviews

Food

7.2

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,051 reviews
Delta
7.9
Good
8,051 reviews

Food

7.2

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,906 reviews
Delta
7.9
Good
8,051 reviews

Food

7.2

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Spirit Airlines
6.3
Okay
8,322 reviews
Delta
7.9
Good
8,051 reviews

Food

7.2

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to South America?

    Myrtle Beach Intl (MYR), located 2.1 mi from the city center, is the airport you fly out of when you book flights from Myrtle Beach to South America.

  • How long is the flight from Myrtle Beach to South America?

    Spirit Airlines, Delta, and American Airlines can get you from Myrtle Beach to South America in just under 13h 26m. Your travel time can differ by up to 1h 44m. There are 3158 mi between Myrtle Beach and South America. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Myrtle Beach to South America?

    When deciding which route to take from Myrtle Beach to South America consider Myrtle Beach Intl - Medellín Jose Maria Cordova Intl, Myrtle Beach Intl - Lima J Chavez Intl or Myrtle Beach Intl - Cali Alfonso B. Aragon Intl as they are the most popular.

  • Can I find deals for flights from Myrtle Beach to South America that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to South America.

  • Can I find deals for business class flights from Myrtle Beach to South America?

    Yes. Cheapflights offers flight deals from Myrtle Beach to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to South America?

    Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to South America (average of $176). Flying from Myrtle Beach to South America in October is currently the most expensive (average of $647). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Myrtle Beach to South America

Discover the top 3 airlines that operate flights from Myrtle Beach to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$327Average$395FlexibilityNo cancel feeOn-time65%
DeltaCheapest$584Average$619FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$593Average$760FlexibilityNo cancel feeOn-time81%

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