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South America

$160+ Cheap flights from Myrtle Beach (MYR) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BOG
May 4 — May 111
Sun 5/4
Sun 5/11
1 adult, Economy
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Cheap flight deals from Myrtle Beach to South America

Keep the following information in mind while searching for Myrtle Beach to South America flight deals. Data was last updated April 29, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$289
(Kiwi.com)

One-way from

$160
(Kiwi.com)
Provider with most accurate pricing for Myrtle Beach Intl-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Sao Paulo (SAO) flights.
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From Myrtle Beach Intl to South America
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One-way flight from Myrtle Beach Intl to South America
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Find flight deals from Myrtle Beach to South America

Cheapest flights from Myrtle Beach to South America
Explore the most affordable flight options available from Myrtle Beach to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/25:32 pmMYR - CTG
1 stop19h 38mSpirit Airlines
Thu 6/51:15 pmCTG - MYR
1 stop6h 50mSpirit Airlines
Deal found 4/28$289
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/36:00 amMYR - MDE
1 stop7h 58mSpirit Airlines
Fri 6/61:53 pmMDE - MYR
1 stop20h 06mSpirit Airlines
Deal found 4/28$383
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/36:00 amMYR - MDE
1 stop7h 58mMultiple Airlines
Sat 6/77:10 amMDE - MYR
2 stops12h 55mMultiple Airlines
Deal found 4/28$398
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/285:32 pmMYR - CTG
2 stops24h 31mMultiple Airlines
Sat 5/311:15 pmCTG - MYR
1 stop6h 50mMultiple Airlines
Deal found 4/28$433
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/88:24 pmMYR - BOG
1 stop16h 33mSpirit Airlines
Thu 7/1712:52 pmBOG - MYR
1 stop27h 45mSpirit Airlines
Deal found 4/29$493
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/67:59 pmMYR - BOG
2 stops15h 56mDelta
Mon 7/147:00 amBOG - MYR
2 stops11h 05mDelta
Deal found 4/29$529
This Mytrip deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/67:25 pmMYR - CLO
2 stops24h 39mMultiple Airlines
Tue 6/172:15 pmCLO - MYR
1 stop19h 18mMultiple Airlines
Deal found 4/28$531
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/84:50 pmMYR - MDE
2 stops36h 52mUnited Airlines
Wed 7/169:45 amMDE - MYR
2 stops51h 21mUnited Airlines
Deal found 4/29$565
This Avianca Connect deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/136:30 amMYR - MAO
2 stops20h 30mMultiple Airlines
Fri 6/204:10 amMAO - MYR
2 stops15h 12mMultiple Airlines
Deal found 4/29$580
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/66:14 pmMYR - CLO
2 stops20h 06mAmerican Airlines
Mon 6/1612:30 amCLO - MYR
2 stops17h 40mAmerican Airlines
Deal found 4/28$585
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/82:26 pmMYR - MDE
2 stops10h 19mAmerican Airlines
Tue 7/1512:45 amMDE - MYR
2 stops12h 11mAmerican Airlines
Deal found 4/29$596
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/128:24 pmMYR - AXM
2 stops44h 17mMultiple Airlines
Thu 6/191:54 pmAXM - MYR
1 stop19h 39mMultiple Airlines
Deal found 4/28$598

Cheapflights Fare Finder

Customize your flight search to find flights from Myrtle Beach to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
Use the filters below to find and compare flights from Myrtle Beach to South America that are best for you.

Fly from

Myrtle Beach

Fly to

South America

Route

Depart

Return

Price

Myrtle BeachCartagena

MYR - CTG

MYRCTG

Myrtle Beach Intl

Mon 6/2

5:32 pm-12:10 pm

1 stop19h 38m

Cartagena Rafael Nunez

Thu 6/5

1:15 pm-9:05 pm

1 stop6h 50m

$289

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

Tue 6/3

6:00 am-12:58 pm

1 stop7h 58m

Medellín Jose Maria Cordova Intl

Fri 6/6

1:53 pm-10:59 am

1 stop20h 06m

$383

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

Tue 6/3

6:00 am-12:58 pm

1 stop7h 58m

Medellín Jose Maria Cordova Intl

Sat 6/7

7:10 am-9:05 pm

2 stops12h 55m

$398

Myrtle BeachCartagena

MYR - CTG

MYRCTG

Myrtle Beach Intl

Wed 5/28

5:32 pm-5:03 pm

2 stops24h 31m

Cartagena Rafael Nunez

Sat 5/31

1:15 pm-9:05 pm

1 stop6h 50m

$433

Myrtle BeachBogotá

MYR - BOG

MYRBOG

Myrtle Beach Intl

Tue 7/8

8:24 pm-11:57 am

1 stop16h 33m

Bogotá El Dorado

Thu 7/17

12:52 pm-5:37 pm

1 stop27h 45m

$493

Myrtle BeachBogotá

MYR - BOG

MYRBOG

Myrtle Beach Intl

Sun 7/6

7:59 pm-10:55 am

2 stops15h 56m

Bogotá El Dorado

Mon 7/14

7:00 am-7:05 pm

2 stops11h 05m

$529

Myrtle BeachCali

MYR - CLO

MYRCLO

Myrtle Beach Intl

Fri 6/6

7:25 pm-7:04 pm

2 stops24h 39m

Cali Alfonso B. Aragon Intl

Tue 6/17

2:15 pm-10:33 am

1 stop19h 18m

$531

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

Tue 7/8

4:50 pm-4:42 am

2 stops36h 52m

Medellín Jose Maria Cordova Intl

Wed 7/16

9:45 am-2:06 pm

2 stops51h 21m

$565

Myrtle BeachManaus

MYR - MAO

MYRMAO

Myrtle Beach Intl

Fri 6/13

6:30 am-3:00 am

2 stops20h 30m

Manaus Eduardo Gomes Intl

Fri 6/20

4:10 am-7:22 pm

2 stops15h 12m

$580

Myrtle BeachCali

MYR - CLO

MYRCLO

Myrtle Beach Intl

Fri 6/6

6:14 pm-1:20 pm

2 stops20h 06m

Cali Alfonso B. Aragon Intl

Mon 6/16

12:30 am-7:10 pm

2 stops17h 40m

$585

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Showing 1-10 of 35 results
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Best time to book a flight from Myrtle Beach to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to South America

What is the cheapest month to book a flight from Myrtle Beach to South America?

Currently, May is the cheapest month in which you can book a flight from Myrtle Beach to South America (average of $359). Flying from Myrtle Beach to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to SA?

Find hourly flight availability from Myrtle Beach to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 29, 2025.

When flying from Myrtle Beach to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated April 29, 2025.
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,936 reviews
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,767 reviews
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Spirit Airlines
6.3
Okay
7,961 reviews
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to South America?

    Myrtle Beach Intl (MYR), located 2.1 mi from the city center, is the airport you fly out of when you book flights from Myrtle Beach to South America.

  • What are the cheapest airlines to fly from Myrtle Beach to South America one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $160. However, be on the lookout for offers from LATAM Airlines and American Airlines, as they are both options that can get you from Myrtle Beach to South America for a low price.

  • What are the most popular routes from Myrtle Beach to South America?

    When deciding which route to take from Myrtle Beach to South America consider Myrtle Beach Intl - Cali Alfonso B. Aragon Intl, Myrtle Beach Intl - Medellín Jose Maria Cordova Intl or Myrtle Beach Intl - Cartagena Rafael Nunez as they are the most popular.

  • Can I find deals for flights from Myrtle Beach to South America that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to South America.

  • Can I find deals for business class flights from Myrtle Beach to South America?

    Yes. Cheapflights offers flight deals from Myrtle Beach to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to South America?

    Currently, May is the cheapest month in which you can book a flight from Myrtle Beach to South America (average of $359). Flying from Myrtle Beach to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to South America

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Top 3 airlines flying from Myrtle Beach to South America

Discover the top 3 airlines that operate flights from Myrtle Beach to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$333Average$477FlexibilityNo cancel feeOn-time65%
DeltaCheapest$379Average$756FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$593Average$722FlexibilityNo cancel feeOn-time81%

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