HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South America

$280+ Cheap flights from Myrtle Beach (MYR) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/24. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BOG
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Myrtle Beach to South America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Myrtle Beach to South America

Keep the following information in mind while searching for Myrtle Beach to South America flight deals. Data was last updated September 16, 2025.

Round-trip from

$355
(Kiwi.com)

One-way from

$280
(KAYAK)
From Myrtle Beach Intl to South America
Search Deals
One-way flight from Myrtle Beach Intl to South America
Search Deals

Find flight deals from Myrtle Beach to South America

Cheapest flights from Myrtle Beach to South America
Explore the most affordable flight options available from Myrtle Beach to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/319:05 pmMYR - MDE
1 stop28h 16mSpirit Airlines
Fri 11/76:59 pmMDE - MYR
1 stop15h 42mSpirit Airlines
Deal found 9/16$355
This Mytrip deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/319:05 pmMYR - MDE
3 stops26h 50mMultiple Airlines
Fri 11/76:59 pmMDE - MYR
1 stop15h 42mMultiple Airlines
Deal found 9/16$427
This Avianca Connect deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/25:20 pmMYR - BOG
1 stop27h 05mMultiple Airlines
Thu 10/308:40 amBOG - MYR
1 stop9h 18mMultiple Airlines
Deal found 9/14$440
This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:30 pmMYR - MDE
1 stop14h 33mSpirit Airlines
Mon 12/156:59 pmMDE - MYR
1 stop15h 42mSpirit Airlines
Deal found 9/15$450
This KAYAK deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/611:46 amMYR - CTG
1 stop25h 22mSpirit Airlines
Mon 11/102:16 pmCTG - MYR
1 stop20h 25mSpirit Airlines
Deal found 9/14$507
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:41 pmMYR - MDE
2 stops10h 58mAmerican Airlines
Mon 12/157:00 amMDE - MYR
2 stops13h 50mAmerican Airlines
Deal found 9/15$541
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:00 amMYR - MDE
2 stops15h 15mAmerican Airlines
Thu 11/61:30 amMDE - MYR
2 stops19h 19mAmerican Airlines
Deal found 9/16$569
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:00 amMYR - LIM
2 stops14h 15mDelta
Fri 11/2812:10 amLIM - MYR
2 stops17h 45mDelta
Deal found 9/15$724
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1212:44 pmMYR - LIM
2 stops16h 26mAmerican Airlines
Fri 11/2812:45 amLIM - MYR
2 stops13h 14mAmerican Airlines
Deal found 9/16$725
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2310:01 amMYR - SCL
2 stops20h 59mAmerican Airlines
Mon 10/2710:15 pmSCL - MYR
2 stops19h 45mAmerican Airlines
Deal found 9/15$734
This Trip.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/237:43 pmMYR - SCL
2 stops42h 08mMultiple Airlines
Sun 10/2612:20 amSCL - MYR
2 stops18h 24mMultiple Airlines
Deal found 9/15$736
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1110:07 amMYR - CLO
2 stops11h 39mAmerican Airlines
Sat 11/293:20 pmCLO - MYR
2 stops19h 13mAmerican Airlines
Deal found 9/14$742

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Myrtle Beach to South America that are best for you.

Fly from

Myrtle Beach

Fly to

South America

Route

Depart

Return

Price

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

Fri 10/31

9:05 pm-12:21 am

1 stop28h 16m

Medellín Jose Maria Cordova Intl

Fri 11/7

6:59 pm-10:41 am

1 stop15h 42m

$355

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

Fri 10/31

9:05 pm-10:55 pm

3 stops26h 50m

Medellín Jose Maria Cordova Intl

Fri 11/7

6:59 pm-10:41 am

1 stop15h 42m

$427

Myrtle BeachBogotá

MYR - BOG

MYRBOG

Myrtle Beach Intl

Thu 10/2

5:20 pm-7:25 pm

1 stop27h 05m

Bogotá El Dorado

Thu 10/30

8:40 am-6:58 pm

1 stop9h 18m

$440

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

Fri 12/5

8:30 pm-11:03 am

1 stop14h 33m

Medellín Jose Maria Cordova Intl

Mon 12/15

6:59 pm-10:41 am

1 stop15h 42m

$450

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

Sat 2/21

11:46 am-9:40 pm

1 stop9h 54m

Medellín Jose Maria Cordova Intl

Mon 3/2

1:00 pm-10:41 am

1 stop21h 41m

$463

Myrtle BeachCartagena

MYR - CTG

MYRCTG

Myrtle Beach Intl

Thu 11/6

11:46 am-1:08 pm

1 stop25h 22m

Cartagena Rafael Nunez

Mon 11/10

2:16 pm-10:41 am

1 stop20h 25m

$507

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

Tue 2/17

11:46 am-11:45 pm

1 stop11h 59m

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

12:59 am-10:41 am

1 stop9h 42m

$511

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

Sat 2/21

11:14 am-11:24 pm

2 stops12h 10m

Medellín Jose Maria Cordova Intl

Sun 3/1

1:20 am-7:13 pm

2 stops17h 53m

$541

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

Fri 12/5

12:41 pm-11:39 pm

2 stops10h 58m

Medellín Jose Maria Cordova Intl

Mon 12/15

7:00 am-8:50 pm

2 stops13h 50m

$541

Myrtle BeachBogotá

MYR - BOG

MYRBOG

Myrtle Beach Intl

Tue 3/10

10:55 am-7:30 pm

1 stop9h 35m

Bogotá El Dorado

Fri 3/13

2:55 pm-11:35 pm

1 stop7h 40m

$543

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 46 results
1
2
3
...
5

Best time to book a flight from Myrtle Beach to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to South America

What is the cheapest month to book a flight from Myrtle Beach to South America?

Currently, May is the cheapest month in which you can book a flight from Myrtle Beach to South America (average of $359). Flying from Myrtle Beach to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to SA?

Find hourly flight availability from Myrtle Beach to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

When flying from Myrtle Beach to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated September 16, 2025.
Peruse reviews from past customers who have flown with LATAM Airlines and Spirit Airlines from Myrtle Beach to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,847 reviews

Comfort

7.4

Overall

7.5

Boarding

7.6

Entertainment

7.0

Food

6.7

Crew

8.0

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
LATAM Airlines
7.5
Good
1,847 reviews
LATAM Airlines
7.5
Good
1,847 reviews

Comfort

7.4

Overall

7.5

Boarding

7.6

Entertainment

7.0

Food

6.7

Crew

8.0

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Spirit Airlines
6.3
Okay
8,019 reviews
LATAM Airlines
7.5
Good
1,847 reviews

Comfort

7.4

Overall

7.5

Boarding

7.6

Entertainment

7.0

Food

6.7

Crew

8.0

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to South America?

    Myrtle Beach Intl (MYR), located 2.1 mi from the city center, is the airport you fly out of when you book flights from Myrtle Beach to South America.

  • How long is the flight from Myrtle Beach to South America?

    Spirit Airlines, Delta, and American Airlines can get you from Myrtle Beach to South America in just under 9h 35m. Your travel time can differ by up to 18h 41m. There are 2024 mi between Myrtle Beach and South America. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Myrtle Beach to South America one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $280. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Myrtle Beach to South America for a low price.

  • What are the most popular routes from Myrtle Beach to South America?

    When deciding which route to take from Myrtle Beach to South America consider Myrtle Beach Intl - Lima J Chavez Intl, Myrtle Beach Intl - Bogotá El Dorado or Myrtle Beach Intl - Medellín Jose Maria Cordova Intl as they are the most popular.

  • Can I find deals for flights from Myrtle Beach to South America that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to South America.

  • Can I find deals for business class flights from Myrtle Beach to South America?

    Yes. Cheapflights offers flight deals from Myrtle Beach to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to South America?

    Currently, May is the cheapest month in which you can book a flight from Myrtle Beach to South America (average of $359). Flying from Myrtle Beach to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to South America

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to John F Kennedy Intl flights
Charlotte to LaGuardia flights
Charlotte to Newark flights
Charlotte to Boston flights
Charlotte to Las Vegas flights
Charlotte to O'Hare Intl flights
Charlotte to Dallas/Fort Worth flights
Charlotte to Denver flights
Charlotte to Dulles Intl flights
Charlotte to Hobby flights
Charlotte to Orlando flights
Charlotte to Sky Harbor Intl flights
Charlotte to Cancún flights
Charlotte to George Bush Intcntl flights
Charlotte to Fort Lauderdale flights
Charlotte to Miami flights
Charlotte to Luis Munoz Marin Intl flights
Charlotte to Los Angeles flights
Charleston to John F Kennedy Intl flights
Charlotte to Baltimore flights
Charleston to Newark flights
Charlotte to Minneapolis flights
Charlotte to Salt Lake City flights
Charlotte to Love Field flights
Charlotte to Heathrow flights
Charleston to LaGuardia flights
Greenville to John F Kennedy Intl flights
Charleston to O'Hare Intl flights
Savannah to John F Kennedy Intl flights
Greenville to Newark flights
Charlotte to Detroit flights
Charlotte to Seattle flights
Greenville to LaGuardia flights
Charlotte to Austin flights
Charlotte to Nashville flights
Charlotte to Midway flights
Charlotte to San Francisco flights
Savannah to Newark flights
Greenville to Dallas/Fort Worth flights
Charleston to Hobby flights
Charlotte to Philadelphia flights
Greenville to Denver flights
Savannah to LaGuardia flights
Charlotte to Cozumel flights
Charleston to Las Vegas flights
Charlotte to Reagan-National flights
Charleston to Denver flights
Charlotte to San Diego flights
Charlotte to Frankfurt flights
Savannah to O'Hare Intl flights

Top 2 airlines flying from Myrtle Beach to South America

Discover the top 2 airlines that operate flights from Myrtle Beach to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$333Average$439FlexibilityNo cancel feeOn-time65%
LATAM AirlinesCheapest$593Average$722FlexibilityNo cancel feeOn-time81%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.