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South America

$137+ Cheap flights from Myrtle Beach (MYR) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BOG
nov. 21 — nov. 281
vie. 11/21
vie. 11/28
1 adult, Economy
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Cheap flight deals from Myrtle Beach to South America

Keep the following information in mind while searching for Myrtle Beach to South America flight deals. Data was last updated octubre 22, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$299
(Expedia)

One-way from

$137
(Cheapflightsfares)
Provider with most accurate pricing for Myrtle Beach Intl-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Sao Paulo (SAO) flights.
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From Myrtle Beach Intl to South America
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One-way flight from Myrtle Beach Intl to South America
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Find flight deals from Myrtle Beach to South America

Cheapest flights from Myrtle Beach to South America
Explore the most affordable flight options available from Myrtle Beach to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 22, 2025.

This Expedia deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/59:54 amMYR - BOG
1 stop15h 01mSpirit Airlines
jue. 12/111:59 amBOG - MYR
1 stop15h 49mSpirit Airlines
Deal found 10/21$299
This Mytrip deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/59:54 amMYR - BOG
1 stop15h 01mMultiple Airlines
jue. 12/114:35 amBOG - MYR
3 stops37h 13mMultiple Airlines
Deal found 10/21$408
This Cheapflightsfares deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/119:54 amMYR - GYE
1 stop13h 49mSpirit Airlines
lun. 12/2212:59 amGYE - MYR
1 stop17h 09mSpirit Airlines
Deal found 10/21$416
This Cheapflightsfares deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/309:54 amMYR - LIM
1 stop12h 41mSpirit Airlines
jue. 1/1511:59 pmLIM - MYR
1 stop10h 42mSpirit Airlines
Deal found 10/21$534
This Avianca Connect deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/176:15 amMYR - UIO
2 stops19h 05mMultiple Airlines
dom. 11/233:30 amUIO - MYR
2 stops16h 33mMultiple Airlines
Deal found 10/20$574
This KAYAK deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/299:54 amMYR - MDE
1 stop15h 20mSpirit Airlines
mié. 12/312:25 amMDE - MYR
1 stop15h 43mSpirit Airlines
Deal found 10/21$574
This KAYAK deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/299:54 amMYR - MDE
1 stop15h 20mSpirit Airlines
mar. 1/62:25 amMDE - MYR
1 stop15h 43mSpirit Airlines
Deal found 10/21$588
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/309:54 amMYR - LIM
1 stop12h 41mMultiple Airlines
mié. 1/142:55 amLIM - MYR
2 stops32h 48mMultiple Airlines
Deal found 10/21$597
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/284:44 pmMYR - MDE
1 stop21h 13mMultiple Airlines
mié. 1/78:25 pmMDE - MYR
2 stops18h 33mMultiple Airlines
Deal found 10/21$602
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/299:54 amMYR - MDE
1 stop15h 20mMultiple Airlines
mié. 1/78:25 pmMDE - MYR
2 stops18h 33mMultiple Airlines
Deal found 10/21$627
This SmartFares deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/307:00 amMYR - LIM
2 stops25h 00mLATAM Airlines
jue. 1/1511:40 pmLIM - MYR
1 stop10h 28mLATAM Airlines
Deal found 10/21$627
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/284:44 pmMYR - MDE
1 stop21h 13mSpirit Airlines
mié. 12/312:25 amMDE - MYR
1 stop15h 43mSpirit Airlines
Deal found 10/21$638

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 22, 2025.
Use the filters below to find and compare flights from Myrtle Beach to South America that are best for you.

Fly from

Myrtle Beach

Fly to

South America

Route

Depart

Return

Price

Myrtle BeachBogotá

MYR - BOG

MYRBOG

Myrtle Beach Intl

vie. 12/5

9:54 am-12:55 am

1 stop15h 01m

Bogotá El Dorado

jue. 12/11

4:35 am-5:48 pm

3 stops37h 13m

$408

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

jue. 12/11

9:54 am-11:43 pm

1 stop13h 49m

Guayaquil Jose Joaquin de Olmedo

lun. 12/22

12:59 am-6:08 pm

1 stop17h 09m

$416

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

sáb. 2/21

11:46 am-9:40 pm

1 stop9h 54m

Medellín Jose Maria Cordova Intl

dom. 3/1

10:45 pm-10:41 am

2 stops35h 56m

$443

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

sáb. 2/21

4:40 pm-9:40 pm

1 stop29h 00m

Medellín Jose Maria Cordova Intl

lun. 3/2

1:00 pm-10:41 am

1 stop21h 41m

$447

Myrtle BeachBogotá

MYR - BOG

MYRBOG

Myrtle Beach Intl

lun. 2/9

11:46 am-2:10 pm

1 stop26h 24m

Bogotá El Dorado

mié. 2/18

8:40 am-9:50 am

1 stop25h 10m

$453

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

mié. 1/7

9:54 am-1:14 am

1 stop15h 20m

Medellín Jose Maria Cordova Intl

dom. 1/11

12:09 pm-7:35 pm

1 stop7h 26m

$496

Myrtle BeachCartagena

MYR - CTG

MYRCTG

Myrtle Beach Intl

sáb. 1/10

11:46 am-1:08 pm

1 stop25h 22m

Cartagena Rafael Nunez

mié. 1/14

2:16 pm-10:41 am

1 stop20h 25m

$497

Myrtle BeachCartagena

MYR - CTG

MYRCTG

Myrtle Beach Intl

sáb. 1/10

11:46 am-1:08 pm

1 stop25h 22m

Cartagena Rafael Nunez

mié. 1/14

2:16 pm-10:05 am

2 stops19h 49m

$505

Myrtle BeachBogotá

MYR - BOG

MYRBOG

Myrtle Beach Intl

lun. 2/9

6:45 pm-12:05 pm

2 stops17h 20m

Bogotá El Dorado

mié. 2/18

10:55 am-11:35 pm

2 stops12h 40m

$508

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

jue. 1/8

11:46 am-12:56 am

1 stop13h 10m

Medellín Jose Maria Cordova Intl

sáb. 1/10

1:51 am-10:41 am

1 stop8h 50m

$530

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/19

Showing 1-10 of 44 results
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Best time to book a flight from Myrtle Beach to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to South America

What is the cheapest month to book a flight from Myrtle Beach to South America?

Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to South America (average of $176). Flying from Myrtle Beach to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to SA?

Find hourly flight availability from Myrtle Beach to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 22, 2025.

One of the essential ways to save on airfare from Myrtle Beach to South America is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 38% on airfare.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated octubre 22, 2025.
Peruse reviews from past customers who have flown with LATAM Airlines and Spirit Airlines from Myrtle Beach to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,869 reviews

Food

6.7

Crew

8.0

Entertainment

7.0

Comfort

7.3

Overall

7.5

Boarding

7.6

Reviews

1 / 20
2.0
Mediocre

Anonymous,Oct 2025

MIA - GRU

Terrible baggage service! Almost lost my connection flight in SP
LATAM Airlines
7.5
Good
1,869 reviews
LATAM Airlines
7.5
Good
1,869 reviews

Food

6.7

Crew

8.0

Entertainment

7.0

Comfort

7.3

Overall

7.5

Boarding

7.6

Reviews

1 / 20
2.0
Mediocre

Anonymous,Oct 2025

MIA - GRU

Terrible baggage service! Almost lost my connection flight in SP
Spirit Airlines
6.3
Okay
8,096 reviews
LATAM Airlines
7.5
Good
1,869 reviews

Food

6.7

Crew

8.0

Entertainment

7.0

Comfort

7.3

Overall

7.5

Boarding

7.6

Reviews

1 / 20
2.0
Mediocre

Anonymous,Oct 2025

MIA - GRU

Terrible baggage service! Almost lost my connection flight in SP

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to South America?

    Myrtle Beach Intl (MYR), located 2.1 mi from the city center, is the airport you fly out of when you book flights from Myrtle Beach to South America.

  • How long is the flight from Myrtle Beach to South America?

    Spirit Airlines, Delta, and LATAM Airlines can get you from Myrtle Beach to South America in just under 13h 49m. Your travel time can differ by up to 11h 11m. There are 2475 mi between Myrtle Beach and South America. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Myrtle Beach to South America?

    When deciding which route to take from Myrtle Beach to South America consider Myrtle Beach Intl - Lima J Chavez Intl, Myrtle Beach Intl - Medellín Jose Maria Cordova Intl or Myrtle Beach Intl - Bogotá El Dorado as they are the most popular.

  • Can I find deals for flights from Myrtle Beach to South America that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to South America.

  • Can I find deals for business class flights from Myrtle Beach to South America?

    Yes. Cheapflights offers flight deals from Myrtle Beach to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to South America?

    Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to South America (average of $176). Flying from Myrtle Beach to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Myrtle Beach to South America

Discover the top 2 airlines that operate flights from Myrtle Beach to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$327Average$414FlexibilityNo cancel feeOn-time65%
LATAM AirlinesCheapest$593Average$722FlexibilityNo cancel feeOn-time81%

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