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South America

$278+ Cheap flights from Myrtle Beach (MYR) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BOG
déc. 20 — déc. 271
sam. 12/20
sam. 12/27
1 adult, Economy
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Cheap flight deals from Myrtle Beach to South America

Keep the following information in mind while searching for Myrtle Beach to South America flight deals. Data was last updated novembre 20, 2025.

Most accurate provider

AranGrant
2 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$356
(KAYAK)

One-way from

$278
(Priceline)
Provider with most accurate pricing for Myrtle Beach Intl-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Sao Paulo (SAO) flights.
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From Myrtle Beach Intl to South America
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One-way flight from Myrtle Beach Intl to South America
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Find flight deals from Myrtle Beach to South America

Cheapest flights from Myrtle Beach to South America
Explore the most affordable flight options available from Myrtle Beach to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on novembre 20, 2025.

This KAYAK deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 12/119:54 amMYR - MDE
1 stop15h 15mSpirit Airlines
ven. 12/123:10 pmMDE - MYR
1 stop26h 38mSpirit Airlines
Deal found 11/19$356
This Mytrip deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 12/119:54 amMYR - MDE
1 stop15h 15mMultiple Airlines
ven. 12/1210:08 pmMDE - MYR
2 stops19h 40mMultiple Airlines
Deal found 11/19$391
This Spirit Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Spirit Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/89:54 amMYR - BOG
1 stop15h 18mSpirit Airlines
mar. 12/92:17 amBOG - MYR
1 stop15h 31mSpirit Airlines
Deal found 11/18$403
This Spirit Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Spirit Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/89:54 amMYR - GYE
1 stop13h 49mSpirit Airlines
mer. 12/1012:49 amGYE - MYR
1 stop16h 59mSpirit Airlines
Deal found 11/19$409
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 11/272:59 pmMYR - MDE
2 stops41h 19mMultiple Airlines
mar. 12/162:05 amMDE - MYR
1 stop15h 43mMultiple Airlines
Deal found 11/20$435
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 11/272:59 pmMYR - MDE
2 stops41h 19mMultiple Airlines
jeu. 12/183:10 pmMDE - MYR
1 stop26h 58mMultiple Airlines
Deal found 11/20$436
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 11/269:46 amMYR - MDE
2 stops37h 33mMultiple Airlines
jeu. 12/112:05 amMDE - MYR
1 stop15h 43mMultiple Airlines
Deal found 11/20$448
This Orbitz deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/256:15 amMYR - MDE
1 stop7h 46mSpirit Airlines
mar. 12/162:05 amMDE - MYR
1 stop15h 43mSpirit Airlines
Deal found 11/20$458
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/252:46 pmMYR - MDE
2 stops32h 43mMultiple Airlines
mar. 12/162:05 amMDE - MYR
1 stop15h 43mMultiple Airlines
Deal found 11/20$460
This Expedia deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 11/276:15 amMYR - MDE
1 stop7h 46mSpirit Airlines
mar. 12/162:05 amMDE - MYR
1 stop15h 43mSpirit Airlines
Deal found 11/20$470
This Orbitz deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 11/276:15 amMYR - BOG
1 stop6h 45mSpirit Airlines
dim. 11/303:17 pmBOG - MYR
1 stop8h 37mSpirit Airlines
Deal found 11/19$541
This KAYAK deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven. 11/212:46 pmMYR - CTG
1 stop22h 39mSpirit Airlines
lun. 11/242:30 pmCTG - MYR
1 stop9h 24mSpirit Airlines
Deal found 11/19$557

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated novembre 20, 2025.
Use the filters below to find and compare flights from Myrtle Beach to South America that are best for you.

Fly from

Myrtle Beach

Fly to

South America

Route

Depart

Return

Price

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

jeu. 12/11

9:54 am-1:09 am

1 stop15h 15m

Medellín Jose Maria Cordova Intl

ven. 12/12

3:10 pm-5:48 pm

1 stop26h 38m

$356

Myrtle BeachBogotá

MYR - BOG

MYRBOG

Myrtle Beach Intl

lun. 12/8

9:54 am-1:12 am

1 stop15h 18m

Bogotá El Dorado

mar. 12/9

2:17 am-5:48 pm

1 stop15h 31m

$403

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

lun. 12/8

9:54 am-11:43 pm

1 stop13h 49m

Guayaquil Jose Joaquin de Olmedo

mer. 12/10

12:49 am-5:48 pm

1 stop16h 59m

$409

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

jeu. 12/11

9:54 am-1:09 am

1 stop15h 15m

Medellín Jose Maria Cordova Intl

ven. 12/12

6:05 am-5:48 pm

3 stops35h 43m

$429

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

mer. 1/28

9:55 pm-12:21 am

2 stops26h 26m

Guayaquil Jose Joaquin de Olmedo

mar. 2/10

1:26 am-2:34 pm

2 stops13h 08m

$516

Myrtle BeachLima

MYR - LIM

MYRLIM

Myrtle Beach Intl

mer. 1/14

9:55 pm-10:35 pm

3 stops24h 40m

Lima J Chavez Intl

mer. 1/28

11:33 pm-2:34 pm

2 stops15h 01m

$539

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

dim. 12/7

9:54 am-1:09 am

1 stop15h 15m

Medellín Jose Maria Cordova Intl

sam. 1/10

6:35 am-12:12 pm

1 stop29h 37m

$557

Myrtle BeachCartagena

MYR - CTG

MYRCTG

Myrtle Beach Intl

lun. 12/8

9:05 am-1:10 pm

2 stops28h 05m

Cartagena Rafael Nunez

jeu. 12/11

2:15 pm-8:49 am

2 stops18h 34m

$575

Myrtle BeachLima

MYR - LIM

MYRLIM

Myrtle Beach Intl

jeu. 1/8

8:15 pm-10:35 pm

1 stop26h 20m

Lima J Chavez Intl

mar. 1/13

11:33 pm-2:34 pm

2 stops15h 01m

$589

Myrtle BeachLima

MYR - LIM

MYRLIM

Myrtle Beach Intl

mer. 1/21

4:07 pm-5:00 am

1 stop12h 53m

Lima J Chavez Intl

mer. 1/28

11:40 pm-9:46 am

1 stop10h 06m

$594

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/17

Showing 1-10 of 33 results
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Best time to book a flight from Myrtle Beach to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to South America

What is the cheapest month to book a flight from Myrtle Beach to South America?

Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to South America (average of $176). Flying from Myrtle Beach to South America in October is currently the most expensive (average of $647). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to SA?

Find hourly flight availability from Myrtle Beach to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated novembre 20, 2025.

One of the essential ways to save on airfare from Myrtle Beach to South America is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 38% on airfare.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated novembre 20, 2025.
Peruse reviews from past customers who have flown with LATAM Airlines and Spirit Airlines from Myrtle Beach to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,882 reviews

Food

6.7

Boarding

7.6

Overall

7.5

Comfort

7.3

Crew

8.0

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Oct 2025

MIA - GRU

Terrible baggage service! Almost lost my connection flight in SP
LATAM Airlines
7.5
Good
1,882 reviews
LATAM Airlines
7.5
Good
1,882 reviews

Food

6.7

Boarding

7.6

Overall

7.5

Comfort

7.3

Crew

8.0

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Oct 2025

MIA - GRU

Terrible baggage service! Almost lost my connection flight in SP
Spirit Airlines
6.3
Okay
8,158 reviews
LATAM Airlines
7.5
Good
1,882 reviews

Food

6.7

Boarding

7.6

Overall

7.5

Comfort

7.3

Crew

8.0

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Oct 2025

MIA - GRU

Terrible baggage service! Almost lost my connection flight in SP

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to South America?

    Myrtle Beach Intl (MYR), located 2.1 mi from the city center, is the airport you fly out of when you book flights from Myrtle Beach to South America.

  • How long is the flight from Myrtle Beach to South America?

    Spirit Airlines, LATAM Airlines, and Delta can get you from Myrtle Beach to South America in just under 12h 53m. Your travel time can differ by up to 2h 22m. There are 3158 mi between Myrtle Beach and South America. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Myrtle Beach to South America?

    When deciding which route to take from Myrtle Beach to South America consider Myrtle Beach Intl - Lima J Chavez Intl, Myrtle Beach Intl - Bogotá El Dorado or Myrtle Beach Intl - Cartagena Rafael Nunez as they are the most popular.

  • Can I find deals for flights from Myrtle Beach to South America that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to South America.

  • Can I find deals for business class flights from Myrtle Beach to South America?

    Yes. Cheapflights offers flight deals from Myrtle Beach to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to South America?

    Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to South America (average of $176). Flying from Myrtle Beach to South America in October is currently the most expensive (average of $647). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to South America

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Top 2 airlines flying from Myrtle Beach to South America

Discover the top 2 airlines that operate flights from Myrtle Beach to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated novembre 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$327Average$414FlexibilityNo cancel feeOn-time65%
LATAM AirlinesCheapest$593Average$722FlexibilityNo cancel feeOn-time81%

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