$362+ Cheap flights from Panama to San Francisco (SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SFO
Oct 10 — Oct 171
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Panama to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama to San Francisco
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama to San FranciscoExplore the most affordable flight options available from Panama to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from Panama to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1912:40 pm -
Nonstop7h 45m
Sat 1/27:36 pm -
Nonstop7h 03m
Deal found 9/7![Copa Airlines logo]()
$652
This Copa Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:44 pm -
Nonstop7h 41m
Sun 11/812:33 am -
Nonstop7h 13m
Deal found 9/10![Copa Airlines logo]()
$663
This Avianca deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/223:50 pm -
1 stop10h 05m
Fri 10/3012:00 am -
1 stop8h 35m
Deal found 9/5![Avianca logo]()
$693
This Avianca deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:30 am -
1 stop9h 25m
Fri 10/3012:00 am -
1 stop8h 35m
Deal found 9/5![Avianca logo]()
$694
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:02 pm -
2 stops22h 21m
Mon 11/95:01 pm -
2 stops18h 12m
Deal found 9/7![American Airlines logo]()
$695
This Avianca deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:25 am -
2 stops20h 10m
Fri 9/2511:55 pm -
1 stop8h 35m
Deal found 9/6![Avianca logo]()
$704
This Avianca deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/83:50 pm -
1 stop10h 05m
Wed 10/1411:55 pm -
1 stop8h 35m
Deal found 9/7![Avianca logo]()
$707
This Avianca deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:30 am -
1 stop9h 20m
Sun 9/132:15 pm -
2 stops17h 00m
Deal found 9/5![Avianca logo]()
$713
This Avianca deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/910:10 am -
2 stops14h 25m
Wed 9/1611:55 pm -
1 stop8h 35m
Deal found 9/7![Avianca logo]()
$715
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/212:02 pm -
1 stop11h 57m
Tue 10/279:46 pm -
1 stop13h 16m
Deal found 9/7![American Airlines logo]()
$726
Best flights from Panama to San FranciscoDiscover carefully curated flight deals from Panama to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from Panama to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This Avianca deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:05 am -
2 stops14h 35m
Mon 11/91:15 pm -
1 stop18h 20m
Deal found 9/5![Avianca logo]()
$693
This Copa Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:08 pm -
Nonstop7h 32m
Sun 11/17:36 pm -
Nonstop7h 10m
Deal found 9/10![Copa Airlines logo]()
$768
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/193:25 pm -
1 stop11h 33m
Sat 1/26:00 am -
1 stop12h 43m
Deal found 9/5![Delta logo]()
$864
This Avianca deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/223:50 pm -
1 stop10h 05m
Fri 10/3012:00 am -
1 stop8h 35m
Deal found 9/5![Avianca logo]()
$693
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1912:40 pm -
Nonstop7h 45m
Sat 1/27:36 pm -
Nonstop7h 03m
Deal found 9/6![Copa Airlines logo]()
$859
This Copa Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:08 pm -
Nonstop7h 32m
Sun 11/812:33 am -
Nonstop7h 13m
Deal found 9/5![Copa Airlines logo]()
$859
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/312:38 pm -
Nonstop7h 47m
Tue 2/1612:42 am -
Nonstop7h 04m
Deal found 9/6![Copa Airlines logo]()
$859
This Copa Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:08 pm -
Nonstop7h 32m
Fri 10/301:31 am -
Nonstop7h 15m
Deal found 9/5![Copa Airlines logo]()
$866
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2112:38 pm -
Nonstop7h 32m
Mon 10/261:31 am -
Nonstop7h 15m
Deal found 9/7![Copa Airlines logo]()
$866
Last-minute flights from Panama to San FranciscoDiscover last-minute flight deals from Panama to San Francisco. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to San Francisco. Data last updated September 10, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:25 am -
2 stops20h 10m
Fri 9/2511:55 pm -
1 stop8h 35m
Deal found 9/6![Avianca logo]()
$704
This Avianca deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:30 am -
1 stop9h 20m
Sun 9/132:15 pm -
2 stops17h 00m
Deal found 9/5![Avianca logo]()
$713
This Avianca deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/83:50 pm -
1 stop10h 05m
Wed 10/1411:55 pm -
1 stop8h 35m
Deal found 9/7![Avianca logo]()
$707
This FlightHub deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/203:50 pm -
1 stop10h 05m
Tue 10/2712:00 am -
1 stop8h 35m
Deal found 9/7![Avianca logo]()
$739
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/212:02 pm -
1 stop11h 57m
Tue 10/279:46 pm -
1 stop13h 16m
Deal found 9/7![American Airlines logo]()
$726
This Avianca deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/223:50 pm -
1 stop10h 05m
Fri 10/3012:00 am -
1 stop8h 35m
Deal found 9/5![Avianca logo]()
$693
This Avianca deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:30 am -
1 stop9h 25m
Fri 10/3012:00 am -
1 stop8h 35m
Deal found 9/5![Avianca logo]()
$694
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:02 pm -
2 stops22h 21m
Mon 11/95:01 pm -
2 stops18h 12m
Deal found 9/7![American Airlines logo]()
$695
One-way flights from Panama to San FranciscoSearch for one-way flight options from Panama to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
Search for one-way flight options from Panama to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
This Copa Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/216:31 pm -
Nonstop7h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Copa Airlines logo]()
$362
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/214:55 pm -
2 stops23h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$382
This Sembo deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Sembo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/146:31 pm -
Nonstop7h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Copa Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:33 pm -
2 stops15h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$406
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/149:33 pm -
2 stops15h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$408
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/239:33 pm -
2 stops15h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$420
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/49:33 pm -
2 stops15h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$423
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/314:55 pm -
2 stops23h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$426
This Kissandfly.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/144:41 pm -
1 stop17h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Lufthansa logo]()
$431
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/134:41 pm -
1 stop21h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![United Airlines logo]()
$432
This KAYAK deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:34 pm -
1 stop12h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![GOL logo]()
$434
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/314:41 pm -
1 stop10h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![United Airlines logo]()
$436
Find flight deals from Panama to San Francisco
Keep the following information in mind while searching for Panama to San Francisco flight deals. Data was last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $693 (Avianca) |
One-way from | $362 (Copa Airlines) |
Popular in | February |
Cheapest in | April |
Average price | $693 |
Good round-trip deal | $755 or less |
Good one-way deal | $576 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from Panama to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Thu 1/21
6:31 pm-11:15 pm
Nonstop7h 44m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$362
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Fri 1/15
4:41 pm-11:59 pm
1 stop10h 18m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$432
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Wed 1/13
4:41 pm-10:42 am
1 stop21h 01m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$432
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Sun 10/4
9:33 pm-9:27 pm
3 stops25h 54m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$518
Quickest round-trip
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Wed 10/21
6:08 pm-11:40 pm
Nonstop7h 32m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$523
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Sat 10/24
6:08 pm-11:40 pm
Nonstop7h 32m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$523
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Wed 10/21
3:30 pm-8:35 am
1 stop19h 05m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$529
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Wed 1/13
4:55 pm-10:53 am
1 stop20h 58m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$552
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Thu 1/21
6:36 pm-9:03 am
3 stops41h 27m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$606
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Sat 10/3
1:16 pm-7:36 pm
1 stop32h 20m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$637
Showing 1-10 of 19 resultsSorted by cheapest first
Best time to book a flight from Panama to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama with our price prediction graph.
PTY-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to San Francisco
PA0-SFO
PTY-SFO
What is the cheapest month to book a flight from Panama to San Francisco?
Currently, April is the cheapest month in which you can book a flight from Panama to San Francisco (average of $612). Flying from Panama to San Francisco in February is currently the most expensive (average of $793). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PA to SFO?
Find hourly flight availability from Panama to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 10, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to San Francisco as you normally would.
Weekly flight availability from Panama to San Francisco
Explore weekly flight availability from Panama to San Francisco. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 10, 2026.
The most flights from PA0 to SFO are scheduled on a Wednesday (3 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (1 on average).
How far ahead should I book a flight from Panama to San Francisco?
Booking 33 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated September 10, 2026.
Read through reviews of airlines operating flights from Panama to San Francisco, such as Copa Airlines,United Airlines, andAvianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Food
6.9
Overall
7.6
Crew
8.1
Comfort
7.4
Entertainment
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Food
6.9
Overall
7.6
Crew
8.1
Comfort
7.4
Entertainment
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Food
6.9
Overall
7.6
Crew
8.1
Comfort
7.4
Entertainment
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Food
6.9
Overall
7.6
Crew
8.1
Comfort
7.4
Entertainment
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Emeryville
San Bruno
Burlingame
Rancho Cordova
Roseville
Fairfield
Cupertino
Newark
Hayward
San Ramon
Redwood City
Manteca
Vallejo
San Carlos
Turlock
Davis
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
San Francisco flight routes
Alternative routes for Panama to San Francisco
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Francisco by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama to San Francisco by cabin class
Find flights from Panama to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama and San Francisco flights
Browse other Panama and San Francisco flight options. Last updated on September 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
Top 3 airlines flying from Panama to San Francisco
Discover the top 3 airlines that operate flights from Panama to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$281 | Average$609 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$393 | Average$755 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$663 | Average$851 | FlexibilityNo cancel fee | On-time69% |