$318+ Cheap flights from Panama to San Francisco (SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/1. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SFO
Jun 19 — Jun 261
Round-trip
1 adult, Economy
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Cheapest flights from Panama to San FranciscoExplore the most affordable flight options available from Panama to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 20, 2026.
Explore the most affordable flight options available from Panama to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 20, 2026.
This Avianca deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:45 am
PTY
- SFO
2 stops15h 55m
Avianca
Wed 11/41:20 pm
SFO
- PTY
1 stop18h 10m
Avianca
Deal found 5/19![Avianca logo]()
$693
This Avianca deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2610:10 am
PTY
- SFO
2 stops15h 45m
Avianca
Tue 10/272:20 pm
SFO
- PTY
2 stops16h 30m
Avianca
Deal found 5/19![Avianca logo]()
$703
This Avianca deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/910:10 am
PTY
- SFO
2 stops14h 25m
Avianca
Thu 7/237:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 5/18![Avianca logo]()
$704
This Avianca deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Tue 7/147:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 5/20![Avianca logo]()
$714
This Avianca deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/910:10 am
PTY
- SFO
2 stops14h 25m
Avianca
Tue 7/142:30 am
SFO
- PTY
1 stop21h 25m
Avianca
Deal found 5/18![Avianca logo]()
$717
This Avianca deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:10 am
PTY
- SFO
2 stops14h 25m
Avianca
Thu 7/162:30 am
SFO
- PTY
1 stop21h 25m
Avianca
Deal found 5/16![Avianca logo]()
$721
This Avianca deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:50 pm
PTY
- SFO
1 stop19h 10m
Avianca
Sat 11/711:10 pm
SFO
- PTY
1 stop8h 20m
Avianca
Deal found 5/16![Avianca logo]()
$723
This Avianca deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:30 am
PTY
- SFO
1 stop19h 05m
Avianca
Sat 5/232:30 am
SFO
- PTY
1 stop21h 25m
Avianca
Deal found 5/17![Avianca logo]()
$725
This United Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:30 pm
PTY
- SFO
1 stop10h 57m
United Airlines
Tue 10/2712:45 am
SFO
- PTY
1 stop11h 00m
United Airlines
Deal found 5/15![United Airlines logo]()
$726
This Avianca deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:30 am
PTY
- SFO
1 stop19h 05m
Avianca
Sat 7/182:30 am
SFO
- PTY
1 stop21h 25m
Avianca
Deal found 5/19![Avianca logo]()
$727
This Copa Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:53 pm
PTY
- SFO
Nonstop7h 47m
Copa Airlines
Sun 7/198:16 pm
SFO
- PTY
Nonstop7h 19m
Copa Airlines
Deal found 5/19![Copa Airlines logo]()
$732
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1911:35 am
PTY
- SFO
1 stop15h 29m
United Airlines
Fri 1/112:45 am
SFO
- PTY
1 stop11h 00m
United Airlines
Deal found 5/17![United Airlines logo]()
$735
Best flights from Panama to San FranciscoDiscover carefully curated flight deals from Panama to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 20, 2026.
Discover carefully curated flight deals from Panama to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 20, 2026.
This Avianca deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/125:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Sat 7/257:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 5/15![Avianca logo]()
$704
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/97:55 am
PTY
- SFO
1 stop14h 15m
United Airlines
Thu 7/2311:59 pm
SFO
- PTY
1 stop16h 38m
United Airlines
Deal found 5/17![United Airlines logo]()
$742
This Copa Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:53 pm
PTY
- SFO
Nonstop7h 47m
Copa Airlines
Thu 8/61:12 am
SFO
- PTY
Nonstop7h 15m
Copa Airlines
Deal found 5/15![Copa Airlines logo]()
$748
This Avianca deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/410:10 am
PTY
- SFO
2 stops15h 45m
Avianca
Fri 8/711:55 pm
SFO
- PTY
1 stop8h 35m
Avianca
Deal found 5/15![Avianca logo]()
$704
This Copa Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:53 pm
PTY
- SFO
Nonstop7h 47m
Copa Airlines
Thu 8/201:12 am
SFO
- PTY
Nonstop7h 15m
Copa Airlines
Deal found 5/16![Copa Airlines logo]()
$748
This United Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1510:00 am
PTY
- SFO
1 stop23h 22m
United Airlines
Tue 6/2311:59 pm
SFO
- PTY
1 stop14h 13m
United Airlines
Deal found 5/16![United Airlines logo]()
$762
This Avianca deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/93:50 pm
PTY
- SFO
1 stop10h 05m
Avianca
Tue 6/167:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 5/15![Avianca logo]()
$704
This Copa Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:53 pm
PTY
- SFO
Nonstop7h 47m
Copa Airlines
Thu 7/238:16 pm
SFO
- PTY
Nonstop7h 19m
Copa Airlines
Deal found 5/17![Copa Airlines logo]()
$748
This United Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/110:00 am
PTY
- SFO
1 stop10h 30m
United Airlines
Fri 7/1011:59 pm
SFO
- PTY
1 stop12h 15m
United Airlines
Deal found 5/19![United Airlines logo]()
$764
This Avianca deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/910:10 am
PTY
- SFO
2 stops14h 25m
Avianca
Tue 7/142:30 am
SFO
- PTY
1 stop21h 25m
Avianca
Deal found 5/18![Avianca logo]()
$717
This Copa Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/125:53 pm
PTY
- SFO
Nonstop7h 47m
Copa Airlines
Fri 7/241:12 am
SFO
- PTY
Nonstop7h 15m
Copa Airlines
Deal found 5/19![Copa Airlines logo]()
$764
Last-minute flights from Panama to San FranciscoDiscover last-minute flight deals from Panama to San Francisco. Data last updated May 20, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to San Francisco. Data last updated May 20, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:30 am
PTY
- SFO
1 stop19h 05m
Avianca
Sat 5/232:30 am
SFO
- PTY
1 stop21h 25m
Avianca
Deal found 5/17![Avianca logo]()
$725
This FlightHub deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/233:50 pm
PTY
- SFO
1 stop10h 05m
Avianca
Mon 5/2511:55 pm
SFO
- PTY
1 stop8h 35m
Avianca
Deal found 5/17![Avianca logo]()
$761
This Avianca deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Tue 7/147:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 5/20![Avianca logo]()
$714
This FlightHub deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Tue 6/92:30 am
SFO
- PTY
2 stops20h 05m
Avianca
Deal found 5/19![Avianca logo]()
$756
This Avianca deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/73:50 pm
PTY
- SFO
2 stops16h 35m
Avianca
Tue 6/92:30 am
SFO
- PTY
1 stop21h 25m
Avianca
Deal found 5/20![Avianca logo]()
$721
This Avianca deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/93:50 pm
PTY
- SFO
1 stop10h 05m
Avianca
Tue 6/167:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 5/16![Avianca logo]()
$704
This FlightHub deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/93:50 pm
PTY
- SFO
1 stop10h 05m
Avianca
Mon 7/67:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 5/16![Avianca logo]()
$750
This United Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:55 am
PTY
- SFO
1 stop15h 49m
United Airlines
Mon 7/65:00 am
SFO
- PTY
1 stop9h 12m
United Airlines
Deal found 5/16![United Airlines logo]()
$754
This Kiwi.com deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/103:50 pm
PTY
- SFO
2 stops16h 35m
Multiple Airlines
Mon 7/610:56 pm
SFO
- PTY
2 stops42h 24m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$759
This United Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1510:00 am
PTY
- SFO
1 stop23h 22m
United Airlines
Tue 6/2311:59 pm
SFO
- PTY
1 stop14h 13m
United Airlines
Deal found 5/16![United Airlines logo]()
$762
This United Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/247:55 am
PTY
- SFO
1 stop11h 40m
United Airlines
Fri 7/1711:59 pm
SFO
- PTY
1 stop16h 38m
United Airlines
Deal found 5/18![United Airlines logo]()
$755
One-way flights from Panama to San FranciscoSearch for one-way flight options from Panama to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 20, 2026.
Search for one-way flight options from Panama to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:10 pm
PTY
- SFO
3 stops30h 47m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$318
This Avianca deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/23:50 pm
PTY
- SFO
1 stop10h 05m
Avianca
Deal found 5/19![Avianca logo]()
$377
This Super.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/73:50 pm
PTY
- SFO
1 stop16h 35m
Avianca
Deal found 5/19![Avianca logo]()
$382
This Avianca deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/245:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Deal found 5/18![Avianca logo]()
$388
This Super.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/33:50 pm
PTY
- SFO
1 stop16h 35m
Avianca
Deal found 5/16![Avianca logo]()
$390
This FlightHub deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/103:50 pm
PTY
- SFO
1 stop16h 35m
Avianca
Deal found 5/18![Avianca logo]()
$393
This FlightHub deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/63:50 pm
PTY
- SFO
1 stop10h 05m
Avianca
Deal found 5/19![Avianca logo]()
$400
This Avianca deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:30 am
PTY
- SFO
1 stop20h 25m
Avianca
Deal found 5/19![Avianca logo]()
$405
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/53:50 pm
PTY
- SFO
2 stops16h 35m
Avianca
Deal found 5/19![Avianca logo]()
$408
This Super.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/14:25 am
PTY
- SFO
2 stops21h 30m
Avianca
Deal found 5/16![Avianca logo]()
$410
This Avianca deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:50 pm
PTY
- SFO
1 stop10h 05m
Avianca
Deal found 5/19![Avianca logo]()
$413
This FlightHub deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/83:50 pm
PTY
- SFO
1 stop23h 00m
Avianca
Deal found 5/19![Avianca logo]()
$417
Find flight deals from Panama to San Francisco
Keep the following information in mind while searching for Panama to San Francisco flight deals. Data was last updated May 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $693 (Avianca) |
One-way from | $318 (Kiwi.com) |
Popular in | February |
Cheapest in | April |
Average price | $704 |
Good round-trip deal | $742 or less |
Good one-way deal | $1,810 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 20, 2026.
Use the filters below to find and compare flights from Panama to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Sun 7/12
5:30 am-12:50 pm
1 stop9h 20m
San Francisco
Sat 7/25
7:45 am-1:55 am
2 stops16h 10m
$704
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Tue 8/4
10:10 am-11:55 pm
2 stops15h 45m
San Francisco
Fri 8/7
11:55 pm-10:30 am
1 stop8h 35m
$704
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Tue 6/9
3:50 pm-11:55 pm
1 stop10h 05m
San Francisco
Tue 6/16
7:45 am-1:55 am
2 stops16h 10m
$704
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Thu 7/9
10:10 am-10:35 pm
2 stops14h 25m
San Francisco
Tue 7/14
2:30 am-1:55 am
1 stop21h 25m
$717
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Thu 7/9
7:55 am-8:10 pm
1 stop14h 15m
San Francisco
Thu 7/23
11:59 pm-6:37 pm
1 stop16h 38m
$742
Quickest round-trip
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Tue 8/4
5:53 pm-11:40 pm
Nonstop7h 47m
San Francisco
Thu 8/6
1:12 am-10:27 am
Nonstop7h 15m
$748
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Mon 8/17
5:53 pm-11:40 pm
Nonstop7h 47m
San Francisco
Thu 8/20
1:12 am-10:27 am
Nonstop7h 15m
$748
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Thu 7/9
5:53 pm-11:40 pm
Nonstop7h 47m
San Francisco
Thu 7/23
8:16 pm-5:35 am
Nonstop7h 19m
$748
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Mon 6/15
10:00 am-7:22 am
1 stop23h 22m
San Francisco
Tue 6/23
11:59 pm-4:12 pm
1 stop14h 13m
$762
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Wed 7/1
10:00 am-6:30 pm
1 stop10h 30m
San Francisco
Fri 7/10
11:59 pm-2:14 pm
1 stop12h 15m
$764
Showing 1-10 of 19 resultsSorted by cheapest first
Best time to book a flight from Panama to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama with our price prediction graph.
PTY-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to San Francisco
PA0-SFO
PTY-SFO
What is the cheapest month to book a flight from Panama to San Francisco?
Currently, April is the cheapest month in which you can book a flight from Panama to San Francisco (average of $153). Flying from Panama to San Francisco in November is currently the most expensive (average of $487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PA to SFO?
Find hourly flight availability from Panama to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 20, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to San Francisco as you normally would.
Weekly flight availability from Panama to San Francisco
Explore weekly flight availability from Panama to San Francisco. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated May 20, 2026.
The most flights from PA0 to SFO are scheduled on a Monday (3 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (2 on average).
How far ahead should I book a flight from Panama to San Francisco?
Booking 35 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated May 20, 2026.
Read through reviews of airlines operating flights from Panama to San Francisco, such as Copa Airlines,United Airlines, andAvianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Entertainment
6.8
Overall
7.5
Comfort
7.4
Boarding
7.7
Food
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Crew
8.1
Entertainment
6.8
Overall
7.5
Comfort
7.4
Boarding
7.7
Food
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Crew
8.1
Entertainment
6.8
Overall
7.5
Comfort
7.4
Boarding
7.7
Food
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Crew
8.1
Entertainment
6.8
Overall
7.5
Comfort
7.4
Boarding
7.7
Food
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
San Bruno
Watsonville
San Ramon
Vacaville
Roseville
San Carlos
Redwood City
Sunnyvale
Turlock
Vallejo
San Lorenzo
Davis
Emeryville
Manteca
Elk Grove
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Panama to San Francisco
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Francisco by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama to San Francisco by cabin class
Find flights from Panama to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama and San Francisco flights
Browse other Panama and San Francisco flight options. Last updated on May 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 20, 2026.
Top 3 airlines flying from Panama to San Francisco
Discover the top 3 airlines that operate flights from Panama to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$281 | Average$535 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$359 | Average$692 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$506 | Average$689 | FlexibilityNo cancel fee | On-time69% |