$360+ Cheap flights from Panama to San Francisco (SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SFO
Aug 22 — Aug 291
Round-trip
1 adult, Economy
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Find cheap flights from Panama to San Francisco with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Panama to San FranciscoExplore the most affordable flight options available from Panama to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.
Explore the most affordable flight options available from Panama to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.
This Avianca deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Fri 9/2511:55 pm
SFO
- PTY
1 stop8h 35m
Avianca
Deal found 7/19![Avianca logo]()
$693
This Avianca deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:50 pm
PTY
- SFO
1 stop19h 10m
Avianca
Mon 11/911:10 pm
SFO
- PTY
1 stop8h 20m
Avianca
Deal found 7/19![Avianca logo]()
$703
This Avianca deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Mon 8/1711:55 pm
SFO
- PTY
1 stop8h 35m
Avianca
Deal found 7/20![Avianca logo]()
$704
This Avianca deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:30 am
PTY
- SFO
1 stop19h 05m
Avianca
Sat 9/262:15 pm
SFO
- PTY
2 stops17h 00m
Avianca
Deal found 7/22![Avianca logo]()
$713
This Avianca deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/163:50 pm
PTY
- SFO
2 stops16h 35m
Avianca
Sat 8/227:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 7/21![Avianca logo]()
$715
This Avianca deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:50 pm
PTY
- SFO
1 stop19h 10m
Avianca
Fri 11/611:10 pm
SFO
- PTY
1 stop8h 20m
Avianca
Deal found 7/19![Avianca logo]()
$723
This oojo deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/173:50 pm
PTY
- SFO
2 stops16h 35m
Avianca
Mon 8/317:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 7/18![Avianca logo]()
$738
This Justfly.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/193:50 pm
PTY
- SFO
2 stops16h 35m
Avianca
Fri 10/3012:10 am
SFO
- PTY
1 stop8h 20m
Avianca
Deal found 7/22![Avianca logo]()
$739
This Justfly.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/193:50 pm
PTY
- SFO
2 stops16h 35m
Avianca
Wed 8/2611:55 pm
SFO
- PTY
2 stops31h 20m
Avianca
Deal found 7/20![Avianca logo]()
$746
This Avianca deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Wed 10/282:20 pm
SFO
- PTY
2 stops16h 30m
Avianca
Deal found 7/21![Avianca logo]()
$748
This FlightHub deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:30 am
PTY
- SFO
1 stop19h 05m
Avianca
Mon 10/2612:10 am
SFO
- PTY
1 stop8h 20m
Avianca
Deal found 7/21![Avianca logo]()
$749
Best flights from Panama to San FranciscoDiscover carefully curated flight deals from Panama to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 23, 2026.
Discover carefully curated flight deals from Panama to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 23, 2026.
This Avianca deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:45 am
PTY
- SFO
2 stops15h 05m
Avianca
Mon 11/91:20 pm
SFO
- PTY
2 stops16h 30m
Avianca
Deal found 7/18![Avianca logo]()
$693
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/212:21 pm
PTY
- SFO
1 stop11h 54m
Delta
Tue 10/2711:45 pm
SFO
- PTY
1 stop11h 11m
Delta
Deal found 7/20![Delta logo]()
$822
This Copa Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:08 pm
PTY
- SFO
Nonstop7h 32m
Copa Airlines
Mon 9/141:12 am
SFO
- PTY
Nonstop7h 15m
Copa Airlines
Deal found 7/21![Copa Airlines logo]()
$823
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:00 am
PTY
- SFO
1 stop12h 10m
United Airlines
Wed 9/97:05 am
SFO
- PTY
1 stop9h 32m
United Airlines
Deal found 7/19![United Airlines logo]()
$829
This oojo deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/173:50 pm
PTY
- SFO
2 stops16h 35m
Avianca
Mon 8/312:15 pm
SFO
- PTY
1 stop9h 40m
Avianca
Deal found 7/18![Avianca logo]()
$738
This Copa Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:31 pm
PTY
- SFO
Nonstop7h 46m
Copa Airlines
Fri 1/112:40 am
SFO
- PTY
Nonstop7h 06m
Copa Airlines
Deal found 7/19![Copa Airlines logo]()
$832
This Copa Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:31 pm
PTY
- SFO
Nonstop7h 41m
Copa Airlines
Tue 11/107:36 pm
SFO
- PTY
Nonstop7h 10m
Copa Airlines
Deal found 7/23![Copa Airlines logo]()
$832
This Copa Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:08 pm
PTY
- SFO
Nonstop7h 32m
Copa Airlines
Thu 9/171:12 am
SFO
- PTY
Nonstop7h 15m
Copa Airlines
Deal found 7/20![Copa Airlines logo]()
$832
This Copa Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:08 pm
PTY
- SFO
Nonstop7h 32m
Copa Airlines
Sun 11/812:33 am
SFO
- PTY
Nonstop7h 13m
Copa Airlines
Deal found 7/18![Copa Airlines logo]()
$832
This Copa Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2012:38 pm
PTY
- SFO
Nonstop7h 21m
Copa Airlines
Wed 8/261:12 am
SFO
- PTY
Nonstop7h 15m
Copa Airlines
Deal found 7/23![Copa Airlines logo]()
$847
This Copa Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/285:53 pm
PTY
- SFO
Nonstop7h 47m
Copa Airlines
Sun 8/308:21 pm
SFO
- PTY
Nonstop7h 14m
Copa Airlines
Deal found 7/21![Copa Airlines logo]()
$847
Last-minute flights from Panama to San FranciscoDiscover last-minute flight deals from Panama to San Francisco. Data last updated July 23, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to San Francisco. Data last updated July 23, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Tue 8/182:15 pm
SFO
- PTY
1 stop18h 15m
Avianca
Deal found 7/18![Avianca logo]()
$763
This Avianca deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Mon 8/1711:55 pm
SFO
- PTY
1 stop8h 35m
Avianca
Deal found 7/20![Avianca logo]()
$704
This Avianca deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Wed 10/282:20 pm
SFO
- PTY
2 stops16h 30m
Avianca
Deal found 7/21![Avianca logo]()
$748
This FlightHub deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:30 am
PTY
- SFO
1 stop19h 05m
Avianca
Mon 10/2612:10 am
SFO
- PTY
1 stop8h 20m
Avianca
Deal found 7/21![Avianca logo]()
$749
This Avianca deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/163:50 pm
PTY
- SFO
2 stops16h 35m
Avianca
Sat 8/227:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 7/21![Avianca logo]()
$715
This oojo deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/173:50 pm
PTY
- SFO
2 stops16h 35m
Avianca
Mon 8/317:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 7/18![Avianca logo]()
$738
This Avianca deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1810:10 am
PTY
- SFO
2 stops14h 25m
Avianca
Tue 8/257:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 7/21![Avianca logo]()
$693
This Justfly.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/193:50 pm
PTY
- SFO
2 stops16h 35m
Avianca
Fri 10/3012:10 am
SFO
- PTY
1 stop8h 20m
Avianca
Deal found 7/22![Avianca logo]()
$739
This Justfly.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/193:50 pm
PTY
- SFO
2 stops16h 35m
Avianca
Wed 8/2611:55 pm
SFO
- PTY
2 stops31h 20m
Avianca
Deal found 7/20![Avianca logo]()
$746
This Avianca deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/285:30 am
PTY
- SFO
1 stop19h 05m
Avianca
Mon 8/317:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 7/21![Avianca logo]()
$703
One-way flights from Panama to San FranciscoSearch for one-way flight options from Panama to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 23, 2026.
Search for one-way flight options from Panama to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:10 am
PTY
- SFO
3 stops34h 10m
Multiple Airlines
Deal found 7/20![Multiple Airlines logo]()
$360
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3110:10 am
PTY
- SFO
3 stops27h 24m
Multiple Airlines
Deal found 7/20![Multiple Airlines logo]()
$361
This Avianca deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Deal found 7/20![Avianca logo]()
$377
This Avianca deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/173:50 pm
PTY
- SFO
1 stop9h 50m
Avianca
Deal found 7/22![Avianca logo]()
$382
This Avianca deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:30 am
PTY
- SFO
1 stop19h 05m
Avianca
Deal found 7/22![Avianca logo]()
$387
This Super.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/173:50 pm
PTY
- SFO
1 stop16h 35m
Avianca
Deal found 7/21![Avianca logo]()
$388
This deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/135:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Deal found 7/19![Avianca logo]()
$413
This Expedia deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/147:50 pm
PTY
- SFO
1 stop19h 10m
Avianca
Deal found 7/20![Avianca logo]()
$423
This Travelocity deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:25 am
PTY
- SFO
2 stops20h 10m
Avianca
Deal found 7/20![Avianca logo]()
$425
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:35 pm
PTY
- SFO
3 stops28h 05m
Multiple Airlines
Deal found 7/21![Multiple Airlines logo]()
$472
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/110:10 am
PTY
- SFO
3 stops59h 42m
Multiple Airlines
Deal found 7/20![Multiple Airlines logo]()
$492
Find flight deals from Panama to San Francisco
Keep the following information in mind while searching for Panama to San Francisco flight deals. Data was last updated July 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $693 (Avianca) |
One-way from | $360 (Kiwi.com) |
Popular in | February |
Cheapest in | September |
Average price | $756 |
Good round-trip deal | $791 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
Use the filters below to find and compare flights from Panama to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Fri 10/30
9:45 am-10:50 pm
2 stops15h 05m
San Francisco
Mon 11/9
1:20 pm-8:50 am
2 stops16h 30m
$693
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Mon 8/17
3:50 pm-6:25 am
2 stops16h 35m
San Francisco
Mon 8/31
2:15 pm-1:55 am
1 stop9h 40m
$738
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Wed 10/21
2:21 pm-12:15 am
1 stop11h 54m
San Francisco
Tue 10/27
11:45 pm-12:56 pm
1 stop11h 11m
$822
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Tue 9/8
6:08 pm-11:40 pm
Nonstop7h 32m
San Francisco
Mon 9/14
1:12 am-10:27 am
Nonstop7h 15m
$823
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Wed 9/2
10:00 am-8:10 pm
1 stop12h 10m
San Francisco
Wed 9/9
7:05 am-6:37 pm
1 stop9h 32m
$829
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Sat 12/19
6:31 pm-11:17 pm
Nonstop7h 46m
San Francisco
Fri 1/1
12:40 am-10:46 am
Nonstop7h 06m
$832
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Sun 11/1
6:31 pm-11:12 pm
Nonstop7h 41m
San Francisco
Tue 11/10
7:36 pm-5:46 am
Nonstop7h 10m
$832
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Mon 9/14
6:08 pm-11:40 pm
Nonstop7h 32m
San Francisco
Thu 9/17
1:12 am-10:27 am
Nonstop7h 15m
$832
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Fri 10/30
6:08 pm-11:40 pm
Nonstop7h 32m
San Francisco
Sun 11/8
12:33 am-10:46 am
Nonstop7h 13m
$832
Quickest round-trip
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Thu 8/20
12:38 pm-5:59 pm
Nonstop7h 21m
San Francisco
Wed 8/26
1:12 am-10:27 am
Nonstop7h 15m
$847
Showing 1-10 of 23 resultsSorted by cheapest first
Best time to book a flight from Panama to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama with our price prediction graph.
PTY-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to San Francisco
PA0-SFO
PTY-SFO
What is the cheapest month to book a flight from Panama to San Francisco?
Currently, September is the cheapest month in which you can book a flight from Panama to San Francisco (average of $609). Flying from Panama to San Francisco in February is currently the most expensive (average of $793). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PA to SFO?
Find hourly flight availability from Panama to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 23, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to San Francisco as you normally would.
Weekly flight availability from Panama to San Francisco
Explore weekly flight availability from Panama to San Francisco. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 23, 2026.
The most flights from PA0 to SFO are scheduled on a Tuesday (3 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (1 on average).
How far ahead should I book a flight from Panama to San Francisco?
Booking 35 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated July 23, 2026.
Read through reviews of airlines operating flights from Panama to San Francisco, such as Copa Airlines,United Airlines, andAvianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.4
Crew
8.1
Food
6.9
Boarding
7.8
Entertainment
6.8
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Comfort
7.4
Crew
8.1
Food
6.9
Boarding
7.8
Entertainment
6.8
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Comfort
7.4
Crew
8.1
Food
6.9
Boarding
7.8
Entertainment
6.8
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Comfort
7.4
Crew
8.1
Food
6.9
Boarding
7.8
Entertainment
6.8
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Fairfield
Roseville
Burlingame
Rancho Cordova
San Bruno
Cupertino
Emeryville
Newark
Watsonville
Hayward
Redwood City
San Carlos
San Ramon
Turlock
Vallejo
San Lorenzo
Davis
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Panama to San Francisco
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Complete your trip
Complete your trip to San Francisco by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama to San Francisco by cabin class
Find flights from Panama to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama and San Francisco flights
Browse other Panama and San Francisco flight options. Last updated on July 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 23, 2026.
Top 3 airlines flying from Panama to San Francisco
Discover the top 3 airlines that operate flights from Panama to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$153 | Average$565 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$374 | Average$743 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$539 | Average$767 | FlexibilityNo cancel fee | On-time69% |