$119+ Cheap flights from Iowa to San Francisco (SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/2. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Oct 27 — Nov 31
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to San Francisco
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Cheapest flights from Iowa to San FranciscoExplore the most affordable flight options available from Iowa to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 27, 2026.
Explore the most affordable flight options available from Iowa to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 27, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/168:04 pm -
1 stop14h 15m
Wed 12/26:30 pm -
1 stop25h 56m
Deal found 9/25![Multiple Airlines logo]()
$179
This Travelocity deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:25 pm -
1 stop16h 52m
Mon 11/26:02 am -
1 stop11h 33m
Deal found 9/25![Frontier logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:30 pm -
1 stop16h 47m
Tue 11/107:14 pm -
1 stop16h 41m
Deal found 9/24![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:11 pm -
1 stop13h 08m
Mon 11/210:23 pm -
2 stops38h 15m
Deal found 9/27![Multiple Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:00 pm -
1 stop18h 25m
Wed 10/287:14 pm -
1 stop25h 36m
Deal found 9/24![Multiple Airlines logo]()
$249
This Expedia deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:25 pm -
1 stop16h 52m
Fri 10/3012:20 pm -
1 stop5h 15m
Deal found 9/27![Frontier logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:30 pm -
1 stop16h 47m
Mon 11/96:02 am -
1 stop11h 33m
Deal found 9/24![Frontier logo]()
$254
This Expedia deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:25 pm -
1 stop16h 40m
Fri 10/3012:20 pm -
1 stop5h 15m
Deal found 9/25![Frontier logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:58 pm -
1 stop13h 15m
Fri 10/235:48 pm -
1 stop24h 26m
Deal found 9/24![Multiple Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:13 pm -
1 stop8h 17m
Tue 11/35:50 am -
1 stop6h 07m
Deal found 9/27![American Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/235:00 pm -
1 stop9h 06m
Sun 12/273:40 pm -
1 stop5h 28m
Deal found 9/27![Delta logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:12 am -
1 stop10h 11m
Fri 10/3010:45 pm -
1 stop7h 54m
Deal found 9/25![United Airlines logo]()
$414
Best flights from Iowa to San FranciscoDiscover carefully curated flight deals from Iowa to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 27, 2026.
Discover carefully curated flight deals from Iowa to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 27, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:25 pm -
1 stop16h 40m
Mon 10/197:25 pm -
2 stops40h 27m
Deal found 9/27![Multiple Airlines logo]()
$313
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:13 am -
1 stop10h 13m
Thu 11/1211:35 pm -
1 stop8h 44m
Deal found 9/25![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:00 am -
2 stops7h 50m
Thu 11/125:50 am -
1 stop5h 20m
Deal found 9/25![Southwest logo]()
$342
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/235:12 pm -
1 stop7h 50m
Tue 12/295:00 am -
1 stop5h 51m
Deal found 9/27![United Airlines logo]()
$361
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/1612:00 pm -
2 stops8h 50m
Wed 1/209:30 am -
2 stops9h 10m
Deal found 9/25![Southwest logo]()
$347
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:07 am -
1 stop9h 21m
Mon 10/123:18 pm -
1 stop6h 33m
Deal found 9/23![American Airlines logo]()
$726
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:46 pm -
1 stop7h 44m
Tue 10/206:10 am -
1 stop6h 40m
Deal found 9/23![United Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:05 pm -
1 stop8h 53m
Fri 10/233:30 pm -
1 stop5h 30m
Deal found 9/23![Delta logo]()
$379
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:50 am -
2 stops8h 55m
Mon 11/210:40 am -
2 stops9h 20m
Deal found 9/26![Southwest logo]()
$375
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2410:57 am -
2 stops13h 18m
Sat 10/3110:59 pm -
1 stop10h 43m
Deal found 9/24![Delta logo]()
$410
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/171:20 pm -
2 stops10h 15m
Tue 10/2011:05 am -
2 stops7h 35m
Deal found 9/26![Southwest logo]()
$375
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:12 am -
1 stop10h 11m
Fri 10/3010:45 pm -
1 stop7h 54m
Deal found 9/25![United Airlines logo]()
$414
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/203:03 pm -
1 stop8h 52m
Wed 10/218:58 pm -
2 stops11h 13m
Deal found 9/27![Delta logo]()
$414
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:46 pm -
1 stop7h 44m
Sun 10/185:00 am -
1 stop6h 07m
Deal found 9/22![United Airlines logo]()
$448
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/235:00 pm -
1 stop9h 06m
Mon 12/286:20 am -
1 stop7h 53m
Deal found 9/22![Delta logo]()
$416
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/235:40 pm -
2 stops8h 45m
Tue 12/297:35 am -
2 stops8h 55m
Deal found 9/27![Southwest logo]()
$431
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:51 pm -
1 stop6h 07m
Mon 10/198:58 pm -
2 stops11h 13m
Deal found 9/23![Delta logo]()
$457
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:00 pm -
1 stop7h 30m
Sun 10/116:10 am -
1 stop10h 13m
Deal found 9/23![United Airlines logo]()
$554
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:03 am -
1 stop8h 39m
Tue 11/34:28 pm -
2 stops15h 56m
Deal found 9/23![United Airlines logo]()
$561
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:39 am -
1 stop6h 13m
Fri 10/912:10 am -
1 stop8h 02m
Deal found 9/27![Delta logo]()
$535
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:39 pm -
2 stops11h 05m
Sun 10/119:00 am -
2 stops12h 51m
Deal found 9/23![American Airlines logo]()
$905
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/58:56 am -
2 stops14h 30m
Wed 12/95:00 am -
1 stop7h 28m
Deal found 9/25![United Airlines logo]()
$574
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:46 pm -
1 stop7h 44m
Sat 10/248:55 am -
2 stops12h 49m
Deal found 9/25![United Airlines logo]()
$592
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:00 pm -
1 stop7h 30m
Mon 10/1210:42 pm -
1 stop8h 13m
Deal found 9/23![United Airlines logo]()
$599
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1010:12 am -
1 stop10h 12m
Fri 10/308:40 am -
2 stops21h 59m
Deal found 9/25![United Airlines logo]()
$622
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:00 am -
1 stop7h 34m
Mon 12/2810:55 pm -
2 stops13h 27m
Deal found 9/26![United Airlines logo]()
$657
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1110:12 am -
1 stop16h 18m
Thu 10/1511:30 pm -
1 stop7h 25m
Deal found 9/26![United Airlines logo]()
$1,006
Last-minute flights from Iowa to San FranciscoDiscover last-minute flight deals from Iowa to San Francisco. Data last updated September 27, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to San Francisco. Data last updated September 27, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:46 pm -
1 stop7h 44m
Tue 10/205:00 am -
1 stop6h 07m
Deal found 9/26![United Airlines logo]()
$414
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:13 pm -
1 stop8h 17m
Fri 10/233:18 pm -
1 stop7h 02m
Deal found 9/26![American Airlines logo]()
$444
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1610:14 pm -
1 stop11h 59m
Fri 11/205:33 pm -
2 stops39h 47m
Deal found 9/22![Multiple Airlines logo]()
$417
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:58 pm -
1 stop13h 15m
Fri 10/235:48 pm -
1 stop24h 26m
Deal found 9/24![Multiple Airlines logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:00 pm -
1 stop18h 25m
Wed 10/287:14 pm -
1 stop25h 36m
Deal found 9/24![Multiple Airlines logo]()
$249
This Expedia deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:25 pm -
1 stop16h 40m
Fri 10/3012:20 pm -
1 stop5h 15m
Deal found 9/25![Frontier logo]()
$261
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:12 am -
1 stop10h 11m
Fri 10/3010:45 pm -
1 stop7h 54m
Deal found 9/25![United Airlines logo]()
$414
This Travelocity deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:25 pm -
1 stop16h 52m
Mon 11/26:02 am -
1 stop11h 33m
Deal found 9/25![Frontier logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:11 pm -
1 stop13h 08m
Mon 11/210:23 pm -
2 stops38h 15m
Deal found 9/27![Multiple Airlines logo]()
$247
This Expedia deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:25 pm -
1 stop16h 52m
Fri 10/3012:20 pm -
1 stop5h 15m
Deal found 9/27![Frontier logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:30 pm -
1 stop29h 50m
Mon 11/96:02 am -
1 stop11h 33m
Deal found 9/24![Frontier logo]()
$269
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:13 pm -
1 stop8h 17m
Tue 11/35:50 am -
1 stop6h 07m
Deal found 9/27![American Airlines logo]()
$379
One-way flights from Iowa to San FranciscoSearch for one-way flight options from Iowa to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 27, 2026.
Search for one-way flight options from Iowa to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 27, 2026.
This Frontier deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:30 pm -
1 stop5h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Frontier logo]()
$119
This Priceline deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/148:26 pm -
1 stop6h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Frontier logo]()
$132
This Frontier deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:30 pm -
1 stop5h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Frontier logo]()
$133
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/241:27 pm -
1 stop8h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![United Airlines logo]()
$169
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/312:05 pm -
2 stops8h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Southwest logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/212:42 pm -
2 stops31h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Multiple Airlines logo]()
$179
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:51 pm -
1 stop6h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Delta logo]()
$185
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/241:20 pm -
2 stops9h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Southwest logo]()
$188
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/128:25 pm -
2 stops24h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Frontier logo]()
$189
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:40 am -
2 stops8h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Southwest logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:59 pm -
1 stop21h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/59:05 pm -
1 stop13h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Multiple Airlines logo]()
$264
Find flight deals from Iowa to San Francisco
Keep the following information in mind while searching for Iowa to San Francisco flight deals. Data was last updated September 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $179 (Kiwi.com) |
One-way from | $119 (Frontier) |
Popular in | June |
Cheapest in | February |
Average price | $386 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 27, 2026.
Use the filters below to find and compare flights from Iowa to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Sat 10/24
1:27 pm-7:34 pm
1 stop8h 07m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$169
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Tue 11/3
12:05 pm-6:20 pm
2 stops8h 15m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$174
Quickest round-trip
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Thu 10/15
7:51 pm-11:58 pm
1 stop6h 07m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$185
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Sat 10/24
1:20 pm-9:15 pm
2 stops9h 55m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$188
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Thu 11/5
6:40 am-1:05 pm
2 stops8h 25m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$190
Cedar RapidsSan Francisco
CID Cedar Rapids - SFO San Francisco
CIDSFO
Cedar Rapids
Fri 10/23
12:59 pm-8:13 am
1 stop21h 14m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$205
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Mon 11/23
1:50 pm-7:05 pm
2 stops7h 15m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$216
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Wed 11/4
4:07 pm-1:45 pm
2 stops23h 38m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$222
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Wed 11/25
1:26 pm-6:16 pm
2 stops30h 50m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$238
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Sun 11/8
7:51 pm-11:58 pm
1 stop6h 07m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$239
Showing 1-10 of 46 resultsSorted by cheapest first
Best time to book a flight from Iowa to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Iowa with our price prediction graph.
DSM-SFO
CID-SFO
MCW-SFO
ALO-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to San Francisco
USIA-SFO
DSM-SFO
CID-SFO
MCW-SFO
ALO-SFO
What is the cheapest month to book a flight from Iowa to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Iowa to San Francisco (average of $398). Flying from Iowa to San Francisco in June is currently the most expensive (average of $552). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Iowa to San Francisco?
Airfare is below average for this route at the moment.
Iowa to San Francisco flights typically cost between $371 and $559 in November.The cheapest round-trip price found within the last 5 days was $179 on Multiple Airlines (Nov 16-Dec 2).
How far ahead should I book a flight from Iowa to San Francisco?
The price you pay for your flight from Iowa to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 64 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Related info for your journey
Find useful and relevant information for your journey from Iowa to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Emeryville
Burlingame
Rancho Cordova
San Bruno
Roseville
Hayward
Cupertino
Newark
Fairfield
San Ramon
Redwood City
Manteca
Vallejo
San Carlos
Turlock
Davis
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Alternative routes for Iowa to San Francisco
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Complete your trip
Complete your trip to San Francisco by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to San Francisco by cabin class
Find flights from Iowa to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and San Francisco flights
Browse other Iowa and San Francisco flight options. Last updated on September 27, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 27, 2026.
Iowa to San Francisco flights
Consider these flights traveling from Iowa to San Francisco.
Top 5 airlines flying from Iowa to San Francisco
Discover the top 5 airlines that operate flights from Iowa to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$120 | Average$300 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$253 | Average$477 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$286 | Average$401 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$309 | Average$476 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$371 | Average$505 | FlexibilityNo cancel fee | On-time63% |