$434+ Cheap flights from La Crosse to San Francisco (LSE - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/3. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — SFO
Dec 9 — Dec 161
Round-trip
1 adult, Economy
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Find cheap flights from La Crosse to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from La Crosse to San Francisco
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Best
Last-minute
One-way
Cheapest flights from La Crosse to San FranciscoExplore the most affordable flight options available from La Crosse to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 9, 2026.
Explore the most affordable flight options available from La Crosse to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2410:10 am -
2 stops16h 25m
Sun 12/276:00 pm -
1 stop15h 08m
Deal found 11/8![Multiple Airlines logo]()
$528
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1712:24 pm -
1 stop9h 35m
Mon 11/231:54 pm -
1 stop8h 26m
Deal found 11/5![American Airlines logo]()
$580
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/231:04 pm -
1 stop9h 25m
Mon 12/287:50 am -
1 stop8h 41m
Deal found 11/8![American Airlines logo]()
$633
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1912:26 pm -
1 stop7h 47m
Sun 11/221:54 pm -
1 stop8h 26m
Deal found 11/5![American Airlines logo]()
$634
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1112:09 pm -
1 stop8h 15m
Sun 1/37:50 am -
1 stop8h 41m
Deal found 11/9![American Airlines logo]()
$649
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/221:04 pm -
1 stop9h 25m
Tue 12/297:50 am -
1 stop8h 41m
Deal found 11/8![American Airlines logo]()
$716
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/231:04 pm -
1 stop9h 25m
Tue 12/292:12 pm -
1 stop8h 18m
Deal found 11/8![American Airlines logo]()
$724
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/221:04 pm -
1 stop9h 25m
Mon 12/287:50 am -
1 stop8h 41m
Deal found 11/8![American Airlines logo]()
$729
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1612:24 pm -
2 stops13h 16m
Tue 11/243:04 pm -
1 stop7h 16m
Deal found 11/5![American Airlines logo]()
$730
Best flights from La Crosse to San FranciscoDiscover carefully curated flight deals from La Crosse to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 9, 2026.
Discover carefully curated flight deals from La Crosse to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 9, 2026.
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/51:04 pm -
1 stop9h 25m
Sat 1/98:17 am -
2 stops13h 37m
Deal found 11/5![American Airlines logo]()
$458
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1912:26 pm -
1 stop7h 47m
Sun 11/221:54 pm -
1 stop8h 26m
Deal found 11/6![American Airlines logo]()
$634
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/221:04 pm -
1 stop9h 25m
Tue 12/297:50 am -
1 stop8h 41m
Deal found 11/8![American Airlines logo]()
$716
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/231:04 pm -
1 stop9h 25m
Tue 12/292:12 pm -
1 stop8h 18m
Deal found 11/8![American Airlines logo]()
$724
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:55 am -
1 stop7h 22m
Sun 1/39:00 am -
2 stops13h 30m
Deal found 11/9![American Airlines logo]()
$742
Last-minute flights from La Crosse to San FranciscoDiscover last-minute flight deals from La Crosse to San Francisco. Data last updated November 9, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to San Francisco. Data last updated November 9, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1612:24 pm -
2 stops13h 16m
Tue 11/243:04 pm -
1 stop7h 16m
Deal found 11/5![American Airlines logo]()
$730
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1712:24 pm -
1 stop9h 35m
Mon 11/231:54 pm -
1 stop8h 26m
Deal found 11/5![American Airlines logo]()
$580
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1912:26 pm -
1 stop7h 47m
Sun 11/221:54 pm -
1 stop8h 26m
Deal found 11/5![American Airlines logo]()
$634
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1112:09 pm -
1 stop8h 15m
Sun 1/37:50 am -
1 stop8h 41m
Deal found 11/9![American Airlines logo]()
$649
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/221:04 pm -
1 stop9h 25m
Tue 12/297:50 am -
1 stop8h 41m
Deal found 11/8![American Airlines logo]()
$716
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/221:04 pm -
1 stop9h 25m
Mon 12/287:50 am -
1 stop8h 41m
Deal found 11/8![American Airlines logo]()
$729
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/231:04 pm -
1 stop9h 25m
Mon 12/287:50 am -
1 stop8h 41m
Deal found 11/8![American Airlines logo]()
$633
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/231:04 pm -
1 stop9h 25m
Tue 12/292:12 pm -
1 stop8h 18m
Deal found 11/8![American Airlines logo]()
$724
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2410:10 am -
2 stops16h 25m
Sun 12/276:00 pm -
1 stop15h 08m
Deal found 11/8![Multiple Airlines logo]()
$528
One-way flights from La Crosse to San FranciscoSearch for one-way flight options from La Crosse to San Francisco. Find affordable one-way fares based on user searches. Data last updated November 9, 2026.
Search for one-way flight options from La Crosse to San Francisco. Find affordable one-way fares based on user searches. Data last updated November 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/310:10 am -
3 stops49h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$434
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/37:05 pm -
1 stop16h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![American Airlines logo]()
$443
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/23:15 pm -
1 stop20h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![American Airlines logo]()
$502
Find flight deals from La Crosse to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from La Crosse (LSE) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $418 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 9, 2026.
Use the filters below to find and compare flights from La Crosse to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
La CrosseSan Francisco
LSE La Crosse - SFO San Francisco
LSESFO
La Crosse
Sun 1/3
10:10 am-9:19 am
3 stops49h 09m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$434
La CrosseSan Francisco
LSE La Crosse - SFO San Francisco
LSESFO
La Crosse
Sun 1/3
7:05 pm-9:49 am
1 stop16h 44m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$443
La CrosseSan Francisco
LSE La Crosse - SFO San Francisco
LSESFO
La Crosse
Tue 1/5
1:04 pm-8:29 pm
1 stop9h 25m
San Francisco
Sat 1/9
8:17 am-11:54 pm
2 stops13h 37m
$458
La CrosseSan Francisco
LSE La Crosse - SFO San Francisco
LSESFO
La Crosse
Sat 1/2
3:15 pm-9:49 am
1 stop20h 34m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$502
Quickest round-trip
La CrosseSan Francisco
LSE La Crosse - SFO San Francisco
LSESFO
La Crosse
Thu 11/19
12:26 pm-6:13 pm
1 stop7h 47m
San Francisco
Sun 11/22
1:54 pm-12:20 am
1 stop8h 26m
$634
La CrosseSan Francisco
LSE La Crosse - SFO San Francisco
LSESFO
La Crosse
Tue 12/22
1:04 pm-8:29 pm
1 stop9h 25m
San Francisco
Tue 12/29
7:50 am-6:31 pm
1 stop8h 41m
$716
La CrosseSan Francisco
LSE La Crosse - SFO San Francisco
LSESFO
La Crosse
Wed 12/23
1:04 pm-8:29 pm
1 stop9h 25m
San Francisco
Tue 12/29
2:12 pm-12:30 am
1 stop8h 18m
$724
La CrosseSan Francisco
LSE La Crosse - SFO San Francisco
LSESFO
La Crosse
Fri 12/11
5:55 am-11:17 am
1 stop7h 22m
San Francisco
Sun 1/3
9:00 am-12:30 am
2 stops13h 30m
$742
Sorted by cheapest first
Compare providers for flights from La Crosse to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from La Crosse to San Francisco in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on La Crosse-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on La Crosse-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from La Crosse-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on La Crosse-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for La Crosse-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from La Crosse to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from La Crosse with our price prediction graph.
LSE-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated November 9, 2026.
Read through reviews of airlines operating flights from La Crosse to San Francisco, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.4
Entertainment
6.8
Overall
7.0
Comfort
7.2
Crew
7.9
Food
6.4
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Boarding
7.4
Entertainment
6.8
Overall
7.0
Comfort
7.2
Crew
7.9
Food
6.4
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from La Crosse to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Hayward
Emeryville
Newark
Burlingame
San Bruno
Rancho Cordova
Vallejo
Cupertino
Fairfield
Redwood City
San Carlos
Sunnyvale
Turlock
Davis
Morgan Hill
Roseville
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La Crosse and San Francisco flights
Browse other La Crosse and San Francisco flight options. Last updated on November 9, 2026.
Other flights from La Crosse
Browse through other flights departing from La Crosse. Flights are based on user searches made on Cheapflights and were last updated on November 9, 2026.
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Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 9, 2026.
Top airline flying from La Crosse to San Francisco
Discover the top airline that operate flights from La Crosse to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$379 | Average$619 | FlexibilityNo cancel fee | On-time71% |