$299+ Cheap flights from La Crosse to San Francisco (LSE - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/27. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — SFO
Jun 12 — Jun 191
Round-trip
1 adult, Economy
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Find cheap flights from La Crosse to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from La Crosse to San Francisco
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Best
Last-minute
Cheapest flights from La Crosse to San FranciscoExplore the most affordable flight options available from La Crosse to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 13, 2026.
Explore the most affordable flight options available from La Crosse to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/278:04 pm
LSE
- SFO
1 stop22h 02m
Multiple Airlines
Wed 8/510:22 pm
SFO
- LSE
2 stops42h 58m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/278:04 pm
LSE
- SFO
2 stops26h 36m
Multiple Airlines
Sun 8/97:11 pm
SFO
- LSE
1 stop22h 09m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/278:04 pm
LSE
- SFO
1 stop22h 02m
Multiple Airlines
Sat 8/85:26 pm
SFO
- LSE
2 stops47h 54m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:04 pm
LSE
- SFO
2 stops26h 36m
Multiple Airlines
Thu 8/67:11 pm
SFO
- LSE
1 stop22h 09m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/278:04 pm
LSE
- SFO
1 stop22h 02m
Multiple Airlines
Tue 8/1110:56 pm
SFO
- LSE
2 stops39h 47m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:04 pm
LSE
- SFO
1 stop22h 02m
Multiple Airlines
Wed 8/510:22 pm
SFO
- LSE
2 stops42h 58m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$337
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/278:04 pm
LSE
- SFO
1 stop22h 02m
Multiple Airlines
Fri 8/710:10 pm
SFO
- LSE
2 stops34h 11m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$341
Best flights from La Crosse to San FranciscoDiscover carefully curated flight deals from La Crosse to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 13, 2026.
Discover carefully curated flight deals from La Crosse to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/278:04 pm
LSE
- SFO
1 stop22h 02m
Multiple Airlines
Thu 8/67:11 pm
SFO
- LSE
1 stop22h 09m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:53 pm
LSE
- SFO
1 stop8h 06m
American Airlines
Sat 8/811:30 pm
SFO
- LSE
2 stops9h 53m
American Airlines
Deal found 5/13![American Airlines logo]()
$506
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/278:04 pm
LSE
- SFO
1 stop22h 02m
Multiple Airlines
Fri 7/3110:10 pm
SFO
- LSE
2 stops40h 20m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$341
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/265:30 pm
LSE
- SFO
2 stops27h 43m
Multiple Airlines
Thu 8/67:11 pm
SFO
- LSE
1 stop22h 09m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$392
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/198:04 pm
LSE
- SFO
1 stop22h 17m
Multiple Airlines
Thu 6/255:16 pm
SFO
- LSE
2 stops23h 58m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$436
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:57 pm
LSE
- SFO
1 stop7h 45m
American Airlines
Sat 8/111:07 pm
SFO
- LSE
1 stop16h 16m
American Airlines
Deal found 5/8![American Airlines logo]()
$590
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:25 pm
LSE
- SFO
1 stop18h 02m
American Airlines
Mon 6/2211:10 pm
SFO
- LSE
1 stop10h 12m
American Airlines
Deal found 5/10![American Airlines logo]()
$606
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:41 pm
LSE
- SFO
1 stop8h 11m
American Airlines
Fri 8/72:41 pm
SFO
- LSE
1 stop7h 40m
American Airlines
Deal found 5/8![American Airlines logo]()
$627
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2312:01 pm
LSE
- SFO
2 stops13h 17m
American Airlines
Sat 8/812:24 pm
SFO
- LSE
2 stops9h 57m
American Airlines
Deal found 5/8![American Airlines logo]()
$638
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/266:00 am
LSE
- SFO
1 stop7h 27m
American Airlines
Sat 8/811:30 pm
SFO
- LSE
2 stops9h 53m
American Airlines
Deal found 5/13![American Airlines logo]()
$669
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:53 pm
LSE
- SFO
1 stop8h 06m
American Airlines
Sat 8/16:00 am
SFO
- LSE
1 stop9h 11m
American Airlines
Deal found 5/8![American Airlines logo]()
$677
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:53 pm
LSE
- SFO
1 stop8h 09m
American Airlines
Fri 8/711:30 pm
SFO
- LSE
2 stops9h 52m
American Airlines
Deal found 5/8![American Airlines logo]()
$680
Last-minute flights from La Crosse to San FranciscoDiscover last-minute flight deals from La Crosse to San Francisco. Data last updated May 13, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to San Francisco. Data last updated May 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:25 pm
LSE
- SFO
1 stop8h 33m
American Airlines
Mon 6/228:24 pm
SFO
- LSE
2 stops12h 58m
American Airlines
Deal found 5/11![American Airlines logo]()
$570
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:26 pm
LSE
- SFO
2 stops24h 55m
Multiple Airlines
Sun 6/287:07 pm
SFO
- LSE
1 stop22h 07m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$487
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:26 pm
LSE
- SFO
2 stops24h 55m
Multiple Airlines
Thu 6/257:07 pm
SFO
- LSE
1 stop22h 07m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$522
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/198:04 pm
LSE
- SFO
1 stop22h 17m
Multiple Airlines
Sun 6/285:21 pm
SFO
- LSE
2 stops23h 53m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$383
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/198:04 pm
LSE
- SFO
1 stop22h 17m
Multiple Airlines
Wed 6/243:26 pm
SFO
- LSE
2 stops49h 48m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$406
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/198:04 pm
LSE
- SFO
1 stop22h 17m
Multiple Airlines
Thu 6/255:16 pm
SFO
- LSE
2 stops23h 58m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$436
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/228:04 pm
LSE
- SFO
1 stop22h 17m
Multiple Airlines
Sun 6/285:21 pm
SFO
- LSE
2 stops23h 53m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$386
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/228:04 pm
LSE
- SFO
2 stops27h 26m
Multiple Airlines
Thu 6/257:07 pm
SFO
- LSE
1 stop22h 07m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$437
Find flight deals from La Crosse to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from La Crosse (LSE) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $299 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 13, 2026.
Use the filters below to find and compare flights from La Crosse to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Mon 7/27
8:04 pm-4:06 pm
1 stop22h 02m
San Francisco
Thu 8/6
7:11 pm-7:20 pm
1 stop22h 09m
$314
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Mon 7/27
8:04 pm-4:06 pm
1 stop22h 02m
San Francisco
Fri 7/31
10:10 pm-4:30 pm
2 stops40h 20m
$341
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Sun 7/26
5:30 pm-7:13 pm
2 stops27h 43m
San Francisco
Thu 8/6
7:11 pm-7:20 pm
1 stop22h 09m
$392
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Fri 6/19
8:04 pm-4:21 pm
1 stop22h 17m
San Francisco
Thu 6/25
5:16 pm-7:14 pm
2 stops23h 58m
$436
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Wed 7/22
5:53 pm-11:59 pm
1 stop8h 06m
San Francisco
Sat 8/8
11:30 pm-11:23 am
2 stops9h 53m
$506
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Tue 7/28
5:57 pm-11:42 pm
1 stop7h 45m
San Francisco
Sat 8/1
11:07 pm-5:23 pm
1 stop16h 16m
$590
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Thu 6/18
5:25 pm-9:27 am
1 stop18h 02m
San Francisco
Mon 6/22
11:10 pm-11:22 am
1 stop10h 12m
$606
Quickest round-trip
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Sat 7/25
5:41 pm-11:52 pm
1 stop8h 11m
San Francisco
Fri 8/7
2:41 pm-12:21 am
1 stop7h 40m
$627
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Thu 7/23
12:01 pm-11:18 pm
2 stops13h 17m
San Francisco
Sat 8/8
12:24 pm-12:21 am
2 stops9h 57m
$638
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Sun 7/26
6:00 am-11:27 am
1 stop7h 27m
San Francisco
Sat 8/8
11:30 pm-11:23 am
2 stops9h 53m
$669
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from La Crosse to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from La Crosse to San Francisco in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on La Crosse-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on La Crosse-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from La Crosse-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on La Crosse-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for La Crosse-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from La Crosse to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from La Crosse with our price prediction graph.
LSE-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated May 13, 2026.
Read through reviews of airlines operating flights from La Crosse to San Francisco, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.5
Food
6.4
Comfort
7.2
Entertainment
6.9
Crew
7.9
Overall
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Boarding
7.5
Food
6.4
Comfort
7.2
Entertainment
6.9
Crew
7.9
Overall
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from La Crosse to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
San Bruno
Watsonville
San Ramon
Vacaville
Roseville
San Carlos
Redwood City
Sunnyvale
Turlock
Vallejo
San Lorenzo
Davis
Emeryville
Manteca
Elk Grove
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La Crosse and San Francisco flights
Browse other La Crosse and San Francisco flight options. Last updated on May 13, 2026.
Other flights from La Crosse
Browse through other flights departing from La Crosse. Flights are based on user searches made on Cheapflights and were last updated on May 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 13, 2026.
Top airline flying from La Crosse to San Francisco
Discover the top airline that operate flights from La Crosse to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$379 | Average$523 | FlexibilityNo cancel fee | On-time71% |