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$437+ Cheap flights from Florence, SC (FLO) to San Francisco Bay Area

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — SFO
Mar 7 — Mar 141
Sat 3/7
Sat 3/14
1 adult, Economy
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Cheap flight deals from Florence to San Francisco Bay Area

Cheapest flights from Florence to San Francisco Bay Area
Explore the most affordable flight options available from Florence to San Francisco Bay Area. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.

This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:16 pm
FLO
-
SFO
1 stop8h 12m
American Airlines
Thu 4/161:16 pm
SFO
-
FLO
1 stop7h 37m
American Airlines
Deal found 2/3$437
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/166:20 pm
FLO
-
SFO
1 stop7h 50m
American Airlines
Fri 2/201:17 pm
SFO
-
FLO
1 stop7h 40m
American Airlines
Deal found 2/2$557
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/195:16 am
FLO
-
SFO
1 stop10h 01m
American Airlines
Mon 2/2311:35 pm
SFO
-
FLO
2 stops14h 46m
American Airlines
Deal found 2/3$562

Find flight deals from Florence to San Francisco Bay Area

Keep the following information in mind while searching for Florence to San Francisco Bay Area flight deals. Data was last updated February 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$437
(American Airlines)
Provider with most accurate pricing for Florence-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-San Francisco flights.
Search Deals
From Florence to San Francisco Bay Area
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to San Francisco Bay Area that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Florence to San Francisco Bay Area that are best for you.

Fly from

Florence

Fly to

San Francisco Bay Area

Route

Depart

Return

Price

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 4/13

4:16 pm-9:28 pm

1 stop8h 12m

San Francisco

Thu 4/16

1:16 pm-11:53 pm

1 stop7h 37m

$437

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 2/20

5:16 am-12:17 pm

1 stop10h 01m

San Francisco

Tue 2/24

12:31 pm-11:08 pm

1 stop7h 37m

$557

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Thu 2/19

6:20 pm-11:10 pm

1 stop7h 50m

San Francisco

Mon 2/23

1:17 pm-11:57 pm

1 stop7h 40m

$557

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 2/16

6:20 pm-11:10 pm

1 stop7h 50m

San Francisco

Fri 2/20

1:17 pm-11:57 pm

1 stop7h 40m

$557

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/3

Best time to book a flight from Florence to San Francisco Bay Area

Have a flexible travel schedule? Discover the best time to fly to San Francisco Bay Area from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to San Francisco Bay Area

What is the cheapest month to book a flight from Florence, South Carolina to San Francisco Bay Area?

Currently, August is the cheapest month in which you can book a flight from Florence, South Carolina to San Francisco Bay Area (average of $106). Flying from Florence, South Carolina to San Francisco Bay Area in January is currently the most expensive (average of $234). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco Bay Area

Get insights into the airlines that provide service to San Francisco Bay Area. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco Bay Area. Reviews last updated February 5, 2026.
Peruse reviews from past customers who have flown with American Airlines from Florence to San Francisco Bay Area to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,237 reviews

Overall

7.2

Crew

8.0

Food

6.4

Entertainment

6.9

Comfort

7.2

Boarding

7.5

Reviews

1 / 20
10.0
Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.
American Airlines
7.2
Good
11,237 reviews
American Airlines
7.2
Good
11,237 reviews

Overall

7.2

Crew

8.0

Food

6.4

Entertainment

6.9

Comfort

7.2

Boarding

7.5

Reviews

1 / 20
10.0
Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.

Related info for your journey

Find useful and relevant information for your journey from Florence to San Francisco Bay Area. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to San Francisco Bay Area?

    Most people fly from Florence (FLO) if they book a flight from Florence to San Francisco Bay Area. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Florence, South Carolina to San Francisco Bay Area?

    For as low as $437, American Airlines can have you in San Francisco Bay Area from Florence, South Carolina in 8h 12m. Airlines will cover a distance of 2377 mi.

  • Can I find deals for flights from Florence to San Francisco Bay Area that include hotel bookings?

    Yes. In addition to deals on Florence to San Francisco Bay Area flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to San Francisco Bay Area?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Francisco Bay Area.

  • Can I find deals for business class flights from Florence to San Francisco Bay Area?

    Yes. Cheapflights offers flight deals from Florence to San Francisco Bay Area by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to San Francisco Bay Area?

    Currently, August is the cheapest month in which you can book a flight from Florence, South Carolina to San Francisco Bay Area (average of $106). Flying from Florence, South Carolina to San Francisco Bay Area in January is currently the most expensive (average of $234). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top airline flying from Florence to San Francisco Bay Area

Discover the top airline that operate flights from Florence to San Francisco Bay Area. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$326Average$426FlexibilityNo cancel feeOn-time71%

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