$367+ Cheap flights from Panama to San Diego (SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SAN
Sep 27 — Oct 41
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama to San Diego
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Best
Last-minute
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Cheapest flights from Panama to San DiegoExplore the most affordable flight options available from Panama to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 28, 2026.
Explore the most affordable flight options available from Panama to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 28, 2026.
This Copa Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/91:48 pm -
Nonstop6h 42m
Fri 10/1610:30 pm -
Nonstop6h 13m
Deal found 8/25![Copa Airlines logo]()
$558
This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/263:41 pm -
1 stop21h 18m
Thu 11/52:30 pm -
2 stops21h 15m
Deal found 8/26![United Airlines logo]()
$564
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/92:02 pm -
2 stops21h 05m
Fri 10/167:15 pm -
2 stops15h 47m
Deal found 8/25![American Airlines logo]()
$565
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/222:02 pm -
1 stop23h 54m
Tue 10/2712:56 pm -
1 stop22h 06m
Deal found 8/25![American Airlines logo]()
$576
This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:30 pm -
2 stops22h 48m
Sun 10/254:45 pm -
2 stops23h 53m
Deal found 8/26![United Airlines logo]()
$577
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/153:30 pm -
2 stops22h 05m
Mon 9/212:24 pm -
2 stops26h 13m
Deal found 8/24![United Airlines logo]()
$585
This Copa Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/131:54 pm -
Nonstop6h 35m
Fri 9/1810:00 pm -
Nonstop6h 17m
Deal found 8/23![Copa Airlines logo]()
$601
This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/173:30 pm -
1 stop21h 28m
Mon 9/213:04 pm -
1 stop25h 33m
Deal found 8/26![United Airlines logo]()
$607
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:16 pm -
2 stops21h 02m
Fri 10/210:27 pm -
2 stops11h 49m
Deal found 8/27![American Airlines logo]()
$610
This BusinessClass deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/221:16 pm -
2 stops21h 58m
Tue 9/299:46 am -
2 stops24h 40m
Deal found 8/23![GOL logo]()
$614
Best flights from Panama to San DiegoDiscover carefully curated flight deals from Panama to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 28, 2026.
Discover carefully curated flight deals from Panama to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 28, 2026.
This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/263:41 pm -
1 stop23h 43m
Thu 11/55:00 pm -
1 stop18h 45m
Deal found 8/26![United Airlines logo]()
$564
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/13:30 pm -
2 stops19h 35m
Sun 10/45:00 pm -
2 stops23h 37m
Deal found 8/24![United Airlines logo]()
$564
This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:30 pm -
2 stops19h 13m
Fri 10/164:46 pm -
1 stop19h 28m
Deal found 8/26![United Airlines logo]()
$564
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:00 am -
1 stop13h 24m
Tue 10/276:26 pm -
2 stops17h 19m
Deal found 8/25![United Airlines logo]()
$564
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:30 pm -
1 stop31h 54m
Fri 10/304:18 pm -
2 stops19h 27m
Deal found 8/24![United Airlines logo]()
$564
This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/263:41 pm -
2 stops25h 14m
Fri 10/306:20 am -
2 stops10h 18m
Deal found 8/26![United Airlines logo]()
$564
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:30 pm -
2 stops22h 48m
Sun 10/254:45 pm -
2 stops23h 53m
Deal found 8/27![United Airlines logo]()
$577
Last-minute flights from Panama to San DiegoDiscover last-minute flight deals from Panama to San Diego. Data last updated August 28, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to San Diego. Data last updated August 28, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:23 pm -
1 stop23h 02m
Mon 9/1410:30 pm -
1 stop12h 28m
Deal found 8/25![Delta logo]()
$660
This Copa Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/131:54 pm -
Nonstop6h 35m
Fri 9/1810:00 pm -
Nonstop6h 17m
Deal found 8/23![Copa Airlines logo]()
$601
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/133:30 pm -
1 stop31h 54m
Fri 9/183:04 pm -
1 stop25h 33m
Deal found 8/27![United Airlines logo]()
$633
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/153:30 pm -
2 stops22h 05m
Mon 9/212:24 pm -
2 stops26h 13m
Deal found 8/24![United Airlines logo]()
$585
This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/173:30 pm -
1 stop21h 28m
Mon 9/213:04 pm -
1 stop25h 33m
Deal found 8/26![United Airlines logo]()
$607
This BusinessClass deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/221:16 pm -
2 stops21h 58m
Tue 9/299:46 am -
2 stops24h 40m
Deal found 8/23![GOL logo]()
$614
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/221:16 pm -
2 stops21h 58m
Tue 9/2912:54 pm -
2 stops21h 32m
Deal found 8/25![American Airlines logo]()
$623
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2210:00 am -
1 stop9h 46m
Tue 9/298:00 am -
1 stop8h 37m
Deal found 8/23![United Airlines logo]()
$624
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:16 pm -
2 stops21h 02m
Fri 10/210:27 pm -
2 stops11h 49m
Deal found 8/27![American Airlines logo]()
$610
One-way flights from Panama to San DiegoSearch for one-way flight options from Panama to San Diego. Find affordable one-way fares based on user searches. Data last updated August 28, 2026.
Search for one-way flight options from Panama to San Diego. Find affordable one-way fares based on user searches. Data last updated August 28, 2026.
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/93:13 pm -
1 stop11h 25m
Deal found 8/28![American Airlines logo]()
$367
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/48:11 am -
3 stops59h 58m
Deal found 8/26![Multiple Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:34 am -
3 stops47h 44m
Deal found 8/26![Multiple Airlines logo]()
$415
This Kiwi.com deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1710:25 am -
3 stops57h 54m
Deal found 8/24![Multiple Airlines logo]()
$443
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/39:45 pm -
3 stops46h 24m
Deal found 8/26![Multiple Airlines logo]()
$444
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/69:45 pm -
3 stops41h 31m
Deal found 8/26![Multiple Airlines logo]()
$451
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/264:00 pm -
3 stops25h 58m
Deal found 8/26![Multiple Airlines logo]()
$454
This Kiwi.com deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/269:45 pm -
3 stops36h 40m
Deal found 8/24![Multiple Airlines logo]()
$461
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:11 am -
3 stops50h 37m
Deal found 8/27![Multiple Airlines logo]()
$468
This Travelocity deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1111:25 am -
3 stops23h 49m
Deal found 8/26![Multiple Airlines logo]()
$469
Find flight deals from Panama to San Diego
Keep the following information in mind while searching for Panama to San Diego flight deals. Data was last updated August 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $558 (Copa Airlines) |
One-way from | $367 (American Airlines) |
Popular in | June |
Cheapest in | November |
Average price | $741 |
Good round-trip deal | $365 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 28, 2026.
Use the filters below to find and compare flights from Panama to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Mon 10/26
3:41 pm-1:24 pm
1 stop23h 43m
San Diego
Thu 11/5
5:00 pm-2:45 pm
1 stop18h 45m
$564
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Thu 10/1
3:30 pm-9:05 am
2 stops19h 35m
San Diego
Sun 10/4
5:00 pm-6:37 pm
2 stops23h 37m
$564
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Fri 10/9
3:30 pm-8:43 am
2 stops19h 13m
San Diego
Fri 10/16
4:46 pm-2:14 pm
1 stop19h 28m
$564
Quickest round-trip
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Thu 10/22
10:00 am-9:24 pm
1 stop13h 24m
San Diego
Tue 10/27
6:26 pm-1:45 pm
2 stops17h 19m
$564
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Fri 10/16
3:30 pm-9:24 pm
1 stop31h 54m
San Diego
Fri 10/30
4:18 pm-1:45 pm
2 stops19h 27m
$564
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Mon 10/26
3:41 pm-2:55 pm
2 stops25h 14m
San Diego
Fri 10/30
6:20 am-6:38 pm
2 stops10h 18m
$564
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Wed 10/21
3:30 pm-12:18 pm
2 stops22h 48m
San Diego
Sun 10/25
4:45 pm-6:38 pm
2 stops23h 53m
$577
Cheapest one-way
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Wed 12/9
3:13 pm-12:11 pm
2 stops23h 58m
$371
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Wed 12/9
5:30 am-4:00 pm
2 stops13h 30m
$484
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Sat 9/26
3:30 pm-11:35 am
2 stops22h 05m
$518
Showing 1-10 of 14 resultsSorted by cheapest first
Best time to book a flight from Panama to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama with our price prediction graph.
PTY-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to San Diego
PA0-SAN
PTY-SAN
What is the cheapest month to book a flight from Panama to San Diego?
Currently, November is the cheapest month in which you can book a flight from Panama to San Diego (average of $434). Flying from Panama to San Diego in June is currently the most expensive (average of $1,217). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PA to SAN?
Find hourly flight availability from Panama to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 28, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to San Diego as you normally would.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated August 28, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and United Airlines from Panama to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Boarding
7.8
Food
6.9
Comfort
7.4
Crew
8.1
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Entertainment
6.8
Boarding
7.8
Food
6.9
Comfort
7.4
Crew
8.1
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Entertainment
6.8
Boarding
7.8
Food
6.9
Comfort
7.4
Crew
8.1
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
Coronado
Poway
San Ysidro
La Mesa
Santee
Julian
Lemon Grove
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Find flights from Panama to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama and San Diego flights
Browse other Panama and San Diego flight options. Last updated on August 28, 2026.
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Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 28, 2026.
Top 2 airlines flying from Panama to San Diego
Discover the top 2 airlines that operate flights from Panama to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$297 | Average$707 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$339 | Average$722 | FlexibilityNo cancel fee | On-time69% |