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$411+ Cheap flights from Panama to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SAN
Jun 17 — Jun 241
Wed 6/17
Wed 6/24
1 adult, Economy
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Cheap flight deals from Panama to San Diego

Cheapest flights from Panama to San Diego
Explore the most affordable flight options available from Panama to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 18, 2026.

This United Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/203:30 pm
PTY
-
SAN
2 stops20h 38m
United Airlines
Sun 7/268:32 pm
SAN
-
PTY
2 stops20h 05m
United Airlines
Deal found 5/15$731
This United Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:41 pm
PTY
-
SAN
2 stops23h 32m
United Airlines
Sat 11/75:00 pm
SAN
-
PTY
2 stops18h 45m
United Airlines
Deal found 5/15$736
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/283:30 pm
PTY
-
SAN
2 stops19h 35m
United Airlines
Tue 9/11:24 pm
SAN
-
PTY
2 stops22h 50m
United Airlines
Deal found 5/17$744
This United Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:00 am
PTY
-
SAN
1 stop11h 50m
United Airlines
Wed 7/296:15 am
SAN
-
PTY
1 stop10h 22m
United Airlines
Deal found 5/16$745
This United Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:00 am
PTY
-
SAN
1 stop11h 50m
United Airlines
Sat 7/258:42 pm
SAN
-
PTY
2 stops15h 32m
United Airlines
Deal found 5/16$750
This Copa Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/202:01 pm
PTY
-
SAN
Nonstop6h 29m
Copa Airlines
Sun 7/2610:00 pm
SAN
-
PTY
Nonstop6h 22m
Copa Airlines
Deal found 5/15$752
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/210:00 am
PTY
-
SAN
1 stop9h 41m
United Airlines
Fri 7/1011:58 am
SAN
-
PTY
1 stop24h 16m
United Airlines
Deal found 5/14$753
This United Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:00 am
PTY
-
SAN
1 stop11h 50m
United Airlines
Mon 7/276:55 pm
SAN
-
PTY
2 stops19h 17m
United Airlines
Deal found 5/16$755
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3010:00 am
PTY
-
SAN
1 stop26h 51m
United Airlines
Wed 7/295:15 pm
SAN
-
PTY
1 stop20h 57m
United Airlines
Deal found 5/13$756
This Expedia deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:50 pm
PTY
-
SAN
2 stops20h 47m
Multiple Airlines
Sun 11/86:32 pm
SAN
-
PTY
2 stops12h 58m
Multiple Airlines
Deal found 5/15$778

Find flight deals from Panama to San Diego

Keep the following information in mind while searching for Panama to San Diego flight deals. Data was last updated May 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$731
(United Airlines)

One-way from

$411
(eDestinos)

Popular in

April

Cheapest in

October

Average price

$701
Provider with most accurate pricing for Panama City Tocumen Intl-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-San Diego flights.
Search Deals
From Panama to San Diego
Search Deals
One-way flight from Panama to San Diego
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($135 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 18, 2026.
Use the filters below to find and compare flights from Panama to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 9/10

10:00 am-10:47 pm

2 stops14h 47m

San Diego

Thu 9/17

6:55 pm-6:37 pm

2 stops21h 42m

$731
Quickest round-trip

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 7/22

3:30 pm-9:59 am

2 stops20h 29m

San Diego

Sun 7/26

6:15 am-6:37 pm

1 stop10h 22m

$731

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 8/28

3:30 pm-12:13 pm

2 stops22h 43m

San Diego

Tue 9/1

8:00 am-6:37 pm

1 stop8h 37m

$744

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 7/2

10:00 am-5:41 pm

1 stop9h 41m

San Diego

Fri 7/10

11:58 am-2:14 pm

1 stop24h 16m

$753
Cheapest one-way

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 6/11

5:30 am-8:48 am

3 stops29h 18m

$442

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Mon 6/22

6:00 pm-8:48 am

3 stops40h 48m

$489

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 6/4

10:28 pm-6:25 pm

2 stops45h 57m

$517

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 6/11

2:24 pm-11:00 pm

1 stop10h 36m

$611

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 6/26

7:55 am-10:25 pm

2 stops16h 30m

$659

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 6/4

10:00 am-7:50 pm

1 stop11h 50m

$693

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/14

Showing 1-10 of 14 resultsSorted by cheapest first
1
2

Best time to book a flight from Panama to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to San Diego

What is the cheapest month to book a flight from Panama to San Diego?

Currently, January is the cheapest month in which you can book a flight from Panama to San Diego (average of $174). Flying from Panama to San Diego in April is currently the most expensive (average of $643). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to SAN?

Find hourly flight availability from Panama to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 18, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to San Diego as you normally would.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated May 18, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and United Airlines from Panama to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,577 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.5

Food

6.8

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.5
Good
1,577 reviews
Copa Airlines
7.5
Good
1,577 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.5

Food

6.8

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
United Airlines
7.4
Good
9,736 reviews
Copa Airlines
7.5
Good
1,577 reviews

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.5

Food

6.8

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Panama to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Panama?

    Most people fly into San Diego (SAN) if they book a flight to San Diego from Panama. San Diego is conveniently located just 2.6 mi from San Diego’s city center.

  • How long is the flight from Panama to San Diego?

    Airlines like United Airlines fly from Panama to San Diego in about 14h 47m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 2910 mi.

  • Can I find deals for flights from Panama to San Diego that include hotel bookings?

    Yes. In addition to deals on Panama to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to San Diego.

  • Can I find deals for business class flights from Panama to San Diego?

    Yes. Cheapflights offers flight deals from Panama to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to San Diego?

    Currently, January is the cheapest month in which you can book a flight from Panama to San Diego (average of $174). Flying from Panama to San Diego in April is currently the most expensive (average of $643). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
Poway
La Mesa
Julian
Lemon Grove

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Panama to San Diego

Discover the top 2 airlines that operate flights from Panama to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$224Average$631FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$361Average$704FlexibilityNo cancel feeOn-time69%

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