$357+ Cheap flights from Panama to San Diego (SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SAN
Nov 8 — Nov 151
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama to San Diego
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Best
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Cheapest flights from Panama to San DiegoExplore the most affordable flight options available from Panama to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 9, 2026.
Explore the most affordable flight options available from Panama to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 9, 2026.
This oojo deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:48 pm -
Nonstop6h 42m
Wed 10/2810:30 pm -
Nonstop6h 13m
Deal found 10/8![Copa Airlines logo]()
$637
This Copa Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/11:45 pm -
Nonstop6h 30m
Wed 11/1110:30 pm -
Nonstop6h 06m
Deal found 10/5![Copa Airlines logo]()
$655
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/14:41 pm -
1 stop21h 18m
Wed 11/115:00 pm -
1 stop23h 38m
Deal found 10/5![United Airlines logo]()
$660
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:30 pm -
2 stops20h 47m
Sun 10/254:45 pm -
2 stops23h 53m
Deal found 10/5![United Airlines logo]()
$674
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:55 am -
2 stops14h 13m
Sun 12/66:20 am -
2 stops10h 18m
Deal found 10/8![United Airlines logo]()
$682
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/232:41 pm -
1 stop12h 18m
Mon 1/410:45 pm -
1 stop13h 48m
Deal found 10/6![American Airlines logo]()
$721
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/24:41 pm -
2 stops19h 29m
Thu 11/128:05 am -
1 stop8h 33m
Deal found 10/6![United Airlines logo]()
$748
Best flights from Panama to San DiegoDiscover carefully curated flight deals from Panama to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 9, 2026.
Discover carefully curated flight deals from Panama to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 9, 2026.
This Copa Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/201:45 pm -
Nonstop6h 30m
Fri 11/2710:30 pm -
Nonstop6h 06m
Deal found 10/6![Copa Airlines logo]()
$655
This United Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/14:41 pm -
2 stops21h 50m
Wed 11/115:00 pm -
1 stop23h 38m
Deal found 10/4![United Airlines logo]()
$660
This Copa Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/11:45 pm -
Nonstop6h 30m
Fri 11/610:30 pm -
Nonstop6h 06m
Deal found 10/4![Copa Airlines logo]()
$655
This United Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/14:41 pm -
2 stops22h 16m
Fri 11/63:04 pm -
1 stop25h 34m
Deal found 10/4![United Airlines logo]()
$660
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:55 am -
2 stops14h 13m
Sun 12/66:20 am -
2 stops10h 18m
Deal found 10/8![United Airlines logo]()
$682
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:41 pm -
2 stops25h 06m
Thu 11/57:41 pm -
2 stops16h 04m
Deal found 10/8![United Airlines logo]()
$682
Last-minute flights from Panama to San DiegoDiscover last-minute flight deals from Panama to San Diego. Data last updated October 9, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to San Diego. Data last updated October 9, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:30 pm -
2 stops20h 47m
Sun 10/254:45 pm -
2 stops23h 53m
Deal found 10/5![United Airlines logo]()
$674
This oojo deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:48 pm -
Nonstop6h 42m
Wed 10/2810:30 pm -
Nonstop6h 13m
Deal found 10/8![Copa Airlines logo]()
$637
This Copa Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/11:45 pm -
Nonstop6h 30m
Wed 11/1110:30 pm -
Nonstop6h 06m
Deal found 10/5![Copa Airlines logo]()
$655
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/14:41 pm -
1 stop21h 18m
Wed 11/115:00 pm -
1 stop23h 38m
Deal found 10/5![United Airlines logo]()
$660
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/24:41 pm -
2 stops19h 29m
Thu 11/128:05 am -
1 stop8h 33m
Deal found 10/6![United Airlines logo]()
$748
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/203:34 pm -
1 stop11h 15m
Fri 11/279:25 pm -
2 stops14h 09m
Deal found 10/6![American Airlines logo]()
$753
One-way flights from Panama to San DiegoSearch for one-way flight options from Panama to San Diego. Find affordable one-way fares based on user searches. Data last updated October 9, 2026.
Search for one-way flight options from Panama to San Diego. Find affordable one-way fares based on user searches. Data last updated October 9, 2026.
This SmartFares deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/161:45 pm -
Nonstop6h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Copa Airlines logo]()
$357
This Copa Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/91:45 pm -
Nonstop6h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Copa Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/168:55 am -
1 stop11h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![United Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/98:55 am -
1 stop10h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![United Airlines logo]()
$368
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/93:29 pm -
1 stop11h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Delta logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:45 pm -
Nonstop6h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Copa Airlines logo]()
$385
This American Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/44:55 pm -
1 stop21h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/4![American Airlines logo]()
$387
Find flight deals from Panama to San Diego
Keep the following information in mind while searching for Panama to San Diego flight deals. Data was last updated October 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $637 (oojo) |
One-way from | $357 (SmartFares) |
Popular in | June |
Cheapest in | November |
Average price | $677 |
Good round-trip deal | $403 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 9, 2026.
Use the filters below to find and compare flights from Panama to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Tue 11/24
4:41 pm-2:55 pm
2 stops25h 14m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$364
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Wed 12/9
3:29 pm-11:38 pm
1 stop11h 09m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$364
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Mon 11/16
8:55 am-5:53 pm
1 stop11h 58m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$364
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Fri 10/30
3:41 pm-11:31 am
2 stops21h 50m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$364
Quickest round-trip
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Wed 12/9
1:45 pm-5:26 pm
Nonstop6h 41m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$369
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Thu 10/22
3:30 pm-12:55 pm
2 stops23h 25m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$373
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Sun 11/15
4:41 pm-10:59 am
1 stop21h 18m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$374
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Fri 11/20
1:45 pm-5:15 pm
Nonstop6h 30m
San Diego
Fri 11/27
10:30 pm-7:36 am
Nonstop6h 06m
$655
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Sun 11/1
1:45 pm-5:15 pm
Nonstop6h 30m
San Diego
Fri 11/6
10:30 pm-7:36 am
Nonstop6h 06m
$655
Panama CitySan Diego
PTY Panama City Tocumen Intl - SAN San Diego
PTYSAN
Panama City Tocumen Intl
Sun 11/1
4:41 pm-11:31 am
2 stops21h 50m
San Diego
Wed 11/11
5:00 pm-7:38 pm
1 stop23h 38m
$660
Showing 1-10 of 13 resultsSorted by cheapest first
Best time to book a flight from Panama to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama with our price prediction graph.
PTY-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to San Diego
PA0-SAN
PTY-SAN
What is the cheapest month to book a flight from Panama to San Diego?
Currently, November is the cheapest month in which you can book a flight from Panama to San Diego (average of $434). Flying from Panama to San Diego in June is currently the most expensive (average of $1,217). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PA to SAN?
Find hourly flight availability from Panama to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 9, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to San Diego as you normally would.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated October 9, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and United Airlines from Panama to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Overall
7.6
Comfort
7.4
Entertainment
6.9
Boarding
7.8
Food
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Crew
8.1
Overall
7.6
Comfort
7.4
Entertainment
6.9
Boarding
7.8
Food
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Crew
8.1
Overall
7.6
Comfort
7.4
Entertainment
6.9
Boarding
7.8
Food
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
San Ysidro
Poway
Coronado
La Mesa
Julian
Santee
Lemon Grove
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Panama and San Diego flights
Browse other Panama and San Diego flight options. Last updated on October 9, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 9, 2026.
Top 2 airlines flying from Panama to San Diego
Discover the top 2 airlines that operate flights from Panama to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$339 | Average$722 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$460 | Average$714 | FlexibilityNo cancel fee | On-time70% |