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$296+ Cheap flights from Panama City (PTY) to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/24. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SAN
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to San Diego are usually found in October or July, booked 75 days in advance, depart on a Tuesday or Monday and return on a Tuesday

Cheap flight deals from Panama City to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$642
(Copa Airlines)

One-way from

$296
(Mytrip)

Popular in

January

Cheapest in

October

Average price

$712

Good round-trip deal

$224 or less

Good one-way deal

$224 or less
From Panama City Tocumen Intl to San Diego
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One-way flight from Panama City Tocumen Intl to San Diego
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Highest demand for flights based on searches. 16% potential increase in price ($110 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to San Diego.
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Price to beat on a one-way flight from Panama City Tocumen Intl to San Diego.
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Find flight deals from Panama City to San Diego

Cheapest flights from Panama City to San Diego
Explore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Copa Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/311:15 pmPTY - SAN
Nonstop6h 42mCopa Airlines
Sun 11/98:10 pmSAN - PTY
Nonstop6h 10mCopa Airlines
Deal found 9/8$642
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/312:55 pmPTY - SAN
3 stops33h 30mMultiple Airlines
Fri 11/78:10 pmSAN - PTY
Nonstop6h 10mMultiple Airlines
Deal found 9/9$644
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/48:55 amPTY - SAN
1 stop15h 58mUnited Airlines
Fri 11/71:10 pmSAN - PTY
1 stop26h 39mUnited Airlines
Deal found 9/11$648
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/233:20 amPTY - SAN
3 stops36h 08mMultiple Airlines
Wed 10/299:07 pmSAN - PTY
Nonstop6h 13mMultiple Airlines
Deal found 9/9$649
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/136:45 pmPTY - SAN
1 stop18h 35mMultiple Airlines
Wed 10/225:19 pmSAN - PTY
1 stop18h 02mMultiple Airlines
Deal found 9/8$652
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/122:49 pmPTY - SAN
1 stop11h 18mAmerican Airlines
Wed 11/192:55 pmSAN - PTY
2 stops19h 43mAmerican Airlines
Deal found 9/10$664
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/265:55 pmPTY - SAN
3 stops24h 37mMultiple Airlines
Sun 11/28:10 pmSAN - PTY
Nonstop6h 10mMultiple Airlines
Deal found 9/11$671
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:45 pmPTY - SAN
1 stop18h 35mMultiple Airlines
Mon 10/205:19 pmSAN - PTY
1 stop18h 02mMultiple Airlines
Deal found 9/8$674
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2410:00 amPTY - SAN
1 stop10h 10mUnited Airlines
Fri 10/317:50 pmSAN - PTY
1 stop19h 59mUnited Airlines
Deal found 9/9$680

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

Fly from

Panama City

Fly to

San Diego

Route

Depart

Return

Price

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 11/2

3:35 pm-12:13 am

1 stop11h 38m

San Diego

Tue 11/11

8:00 am-7:38 pm

1 stop8h 38m

$648

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 11/5

3:21 pm-11:14 pm

1 stop10h 53m

San Diego

Mon 11/10

10:30 pm-2:12 pm

1 stop12h 42m

$648

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 11/5

8:55 am-8:54 pm

2 stops14h 59m

San Diego

Mon 11/10

5:55 pm-2:45 pm

3 stops17h 50m

$648

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Mon 11/3

3:35 pm-12:13 am

1 stop11h 38m

San Diego

Wed 11/12

5:50 pm-2:45 pm

1 stop17h 55m

$648

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sat 11/1

7:55 am-4:25 pm

1 stop10h 30m

San Diego

Wed 11/12

5:55 pm-2:45 pm

3 stops17h 50m

$648

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 10/29

7:55 am-4:25 pm

1 stop10h 30m

San Diego

Thu 11/6

4:01 pm-2:45 pm

2 stops19h 44m

$648

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 11/2

3:35 pm-12:13 am

1 stop11h 38m

San Diego

Sun 11/9

8:40 pm-2:45 pm

2 stops15h 05m

$648

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Mon 11/3

4:41 pm-10:21 am

2 stops20h 40m

San Diego

Sat 11/8

1:47 pm-7:38 pm

1 stop26h 51m

$648

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 10/29

7:55 am-7:52 pm

2 stops13h 57m

San Diego

Fri 11/7

11:02 am-2:45 pm

2 stops24h 43m

$648

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 11/4

8:55 am-11:44 pm

2 stops17h 49m

San Diego

Sat 11/8

8:00 am-7:38 pm

1 stop8h 38m

$648

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/8

Showing 1-10 of 18 results
1
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Best time to book a flight from Panama City to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Diego

How far ahead should I book a flight from Panama City to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to San Diego. Price data was last updated on August 29, 2025.

The price you pay for your flight from Panama City to San Diego may vary depending on when you book. For the best chance of a lower fare, look to book 75 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to San Diego?

Currently, August is the cheapest month in which you can book a flight from Panama City to San Diego (average of $286). Flying from Panama City to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SAN?

Find hourly flight availability from Panama City to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s optimal to fly from Panama City to San Diego at noon. By choosing this option you can save up to 71% on the cost of your flight, compared to a flight in the evening.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated September 11, 2025.
Peruse reviews from past customers who have flown with Copa Airlines and United Airlines from Panama City to San Diego to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Entertainment

6.8

Crew

8.1

Boarding

7.8

Comfort

7.4

Overall

7.6

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Entertainment

6.8

Crew

8.1

Boarding

7.8

Comfort

7.4

Overall

7.6

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
United Airlines
7.4
Good
8,937 reviews
Copa Airlines
7.6
Good
1,531 reviews

Entertainment

6.8

Crew

8.1

Boarding

7.8

Comfort

7.4

Overall

7.6

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to San Diego?

    A quick flight from Panama City to San Diego can take about 11h 38m. United Airlines provides one of the quickest options available for as low as $648. Airlines will cover a distance of 2910 mi.

  • What are the cheapest airlines flying from Panama City to San Diego round-trip?

    Copa Airlines, at $224, was found to be the cheapest airline from Panama City to San Diego. An alternate airline flying to your destination would be United Airlines. Users have found that Copa Airlines is 61% cheaper than the other options available to this destination.

  • What are the cheapest flights from Panama City to San Diego?

    On average you can expect to pay $366 for a flight from Panama City to San Diego. The cheapest flight overall is $224 while the most popular route, (Panama City Tocumen Intl - San Diego) is currently priced at $626.

  • Can I find deals for flights from Panama City to San Diego that include hotel bookings?

    Yes. In addition to deals on Panama City to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Diego.

  • Can I find deals for business class flights from Panama City to San Diego?

    Yes. Cheapflights offers flight deals from Panama City to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Panama City to San Diego (average of $286). Flying from Panama City to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
La Mesa
Poway
Lemon Grove
Coronado
Imperial Beach
National City
Alpine

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Panama City to San Diego

Discover the top 2 airlines that operate flights from Panama City to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$224Average$443FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$361Average$600FlexibilityNo cancel feeOn-time69%

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