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$245+ Cheap flights from Panama City (PTY) to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/13. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SAN
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Panama City to San Diego

Cheapest flights from Panama City to San Diego
Explore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/263:35 pmPTY - SAN
1 stop11h 40mUnited Airlines
Mon 12/295:10 pmSAN - PTY
1 stop18h 35mUnited Airlines
Deal found 12/11$443
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:55 amPTY - SAN
2 stops14h 52mUnited Airlines
Thu 1/16:55 pmSAN - PTY
2 stops19h 12mUnited Airlines
Deal found 12/11$461
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/204:41 pmPTY - SAN
2 stops19h 58mUnited Airlines
Mon 1/55:40 pmSAN - PTY
3 stops18h 05mUnited Airlines
Deal found 12/11$488
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/234:55 pmPTY - SAN
2 stops18h 53mAmerican Airlines
Thu 1/110:01 pmSAN - PTY
2 stops14h 53mAmerican Airlines
Deal found 12/11$651
This Copa Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:55 amPTY - SAN
1 stop15h 02mCopa Airlines
Wed 12/318:12 pmSAN - PTY
Nonstop6h 08mCopa Airlines
Deal found 12/11$881
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:41 pmPTY - SAN
3 stops25h 21mUnited Airlines
Sun 12/285:10 pmSAN - PTY
1 stop20h 57mUnited Airlines
Deal found 12/11$900
This Ovago deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:09 amPTY - SAN
1 stop31h 07mMultiple Airlines
Mon 1/58:16 pmSAN - PTY
Nonstop6h 04mMultiple Airlines
Deal found 12/11$938

Find flight deals from Panama City to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$429
(Copa Airlines)

One-way from

$245
(Copa Airlines)

Popular in

February

Cheapest in

October

Average price

$568

Good one-way deal

$244 or less
Provider with most accurate pricing for Panama City Tocumen Intl-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-San Diego flights.
Search Deals
From Panama City Tocumen Intl to San Diego
Search Deals
One-way flight from Panama City Tocumen Intl to San Diego
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($120 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to San Diego.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

Fly from

Panama City

Fly to

San Diego

Route

Depart

Return

Price

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 1/18

4:41 pm-10:27 am

2 stops20h 46m

San Diego

Fri 1/23

6:00 pm-5:07 pm

2 stops20h 07m

$448

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sat 1/24

5:00 pm-11:39 am

2 stops21h 39m

San Diego

Sat 1/31

10:25 pm-3:38 pm

1 stop14h 13m

$448

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 12/23

4:41 pm-10:30 am

2 stops20h 49m

San Diego

Thu 1/1

8:00 am-7:38 pm

1 stop8h 38m

$461

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 1/27

4:41 pm-11:05 am

1 stop21h 24m

San Diego

Tue 2/3

7:52 pm-7:38 pm

2 stops20h 46m

$541

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 1/27

4:41 pm-10:27 am

2 stops20h 46m

San Diego

Wed 2/4

8:00 am-7:38 pm

1 stop8h 38m

$555

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 1/14

1:45 pm-5:41 pm

Nonstop6h 56m

$245

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 1/13

1:45 pm-5:41 pm

Nonstop6h 56m

$245

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 1/14

4:41 pm-10:27 am

2 stops20h 46m

$250

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 12/31

4:41 pm-8:16 pm

1 stop30h 35m

$250

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sat 12/20

4:41 pm-9:39 am

2 stops19h 58m

$277

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 14 results
1
2

Compare providers for flights from Panama City to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Diego in December.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-San Diego flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-San Diego flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-San Diego flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Diego

What is the cheapest month to book a flight from Panama City to San Diego?

Currently, January is the cheapest month in which you can book a flight from Panama City to San Diego (average of $219). Flying from Panama City to San Diego in April is currently the most expensive (average of $600). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SAN?

Find hourly flight availability from Panama City to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

It’s optimal to fly from Panama City to San Diego at noon. By choosing this option you can save up to 66% on the cost of your flight, compared to a flight in the evening.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated December 12, 2025.
Peruse reviews from past customers who have flown with Copa Airlines and United Airlines from Panama City to San Diego to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,558 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Crew

8.1

Overall

7.6

Food

6.9

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,558 reviews
Copa Airlines
7.6
Good
1,558 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Crew

8.1

Overall

7.6

Food

6.9

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
United Airlines
7.4
Good
9,095 reviews
Copa Airlines
7.6
Good
1,558 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Crew

8.1

Overall

7.6

Food

6.9

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to San Diego?

    Booking a flight from Panama City Tocumen Intl (PTY) to San Diego (SAN) is your only option if you wish to fly from Panama City to San Diego. On a typical day, there is 1 flight from Tocumen Intl to San Diego, all of which are around 6h 39m for a nonstop flight. You can also purchase a plane ticket from 2 airlines when you book a flight from Tocumen Intl to San Diego.

  • How long is the flight from Panama City to San Diego?

    A quick flight from Panama City to San Diego can take about 20h 46m. United Airlines provides one of the quickest options available for as low as $448. Airlines will cover a distance of 2910 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City to San Diego round-trip?

    Copa Airlines, at $224, was found to be the cheapest airline from Panama City to San Diego. An alternate airline flying to your destination would be United Airlines. Users have found that Copa Airlines is 57% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Panama City to San Diego one-way?

    $224 is the cheapest one-way deal found within the past few days, from Copa Airlines. You may also be able to find cheap deals on United Airlines and Delta, with prices starting from $347 and $362, respectively.

  • What are the cheapest flights from Panama City to San Diego?

    On average you can expect to pay $244 for a flight from Panama City to San Diego. The cheapest flight overall is $244 while the most popular route, (Panama City Tocumen Intl - San Diego) is currently priced at $419.

  • Can I find deals for flights from Panama City to San Diego that include hotel bookings?

    Yes. In addition to deals on Panama City to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Diego.

  • Can I find deals for business class flights from Panama City to San Diego?

    Yes. Cheapflights offers flight deals from Panama City to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to San Diego?

    Currently, January is the cheapest month in which you can book a flight from Panama City to San Diego (average of $219). Flying from Panama City to San Diego in April is currently the most expensive (average of $600). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
Lemon Grove
Julian
National City

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Top 2 airlines flying from Panama City to San Diego

Discover the top 2 airlines that operate flights from Panama City to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$224Average$460FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$361Average$600FlexibilityNo cancel feeOn-time69%

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