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$245+ Cheap flights from Panama City (PTY) to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SAN
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheap flight deals from Panama City to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$429
(Copa Airlines)

One-way from

$245
(Delta)

Popular in

January

Cheapest in

October

Average price

$406

Good round-trip deal

$460 or less

Good one-way deal

$501 or less
Provider with most accurate pricing for Panama City Tocumen Intl-San Diego flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-San Diego flights.
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From Panama City Tocumen Intl to San Diego
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One-way flight from Panama City Tocumen Intl to San Diego
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Highest demand for flights based on searches. 18% potential increase in price ($125 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to San Diego.
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Price to beat on a one-way flight from Panama City Tocumen Intl to San Diego.
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Find flight deals from Panama City to San Diego

Cheapest flights from Panama City to San Diego
Explore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Copa Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/161:45 pmPTY - SAN
Nonstop6h 52mCopa Airlines
Mon 1/58:16 pmSAN - PTY
Nonstop6h 04mCopa Airlines
Deal found 10/28$429
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/273:35 pmPTY - SAN
1 stop11h 38mUnited Airlines
Sat 12/65:45 pmSAN - PTY
2 stops18h 00mUnited Airlines
Deal found 10/28$434
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/252:43 pmPTY - SAN
1 stop12h 10mAmerican Airlines
Tue 12/210:15 pmSAN - PTY
1 stop12h 32mAmerican Airlines
Deal found 10/26$443
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/53:21 pmPTY - SAN
1 stop10h 53mDelta
Mon 11/109:50 pmSAN - PTY
1 stop13h 22mDelta
Deal found 10/27$450
This Copa Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/51:15 pmPTY - SAN
Nonstop6h 48mCopa Airlines
Mon 11/108:10 pmSAN - PTY
Nonstop6h 10mCopa Airlines
Deal found 10/27$461
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/58:55 amPTY - SAN
2 stops14h 53mUnited Airlines
Mon 11/105:55 pmSAN - PTY
3 stops17h 50mUnited Airlines
Deal found 10/28$466
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/64:43 pmPTY - SAN
2 stops19h 04mAmerican Airlines
Fri 12/1210:45 pmSAN - PTY
2 stops13h 57mAmerican Airlines
Deal found 10/26$501
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:55 amPTY - SAN
1 stop29h 06mUnited Airlines
Sat 1/37:55 pmSAN - PTY
1 stop19h 54mUnited Airlines
Deal found 10/28$505
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/162:50 pmPTY - SAN
1 stop11h 10mAmerican Airlines
Mon 1/510:30 pmSAN - PTY
1 stop14h 01mAmerican Airlines
Deal found 10/27$514
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/294:41 pmPTY - SAN
2 stops23h 18mUnited Airlines
Sun 1/48:45 pmSAN - PTY
2 stops17h 22mUnited Airlines
Deal found 10/28$518

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

Fly from

Panama City

Fly to

San Diego

Route

Depart

Return

Price

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 1/16

1:45 pm-5:41 pm

Nonstop6h 56m

San Diego

Mon 1/19

8:16 pm-5:20 am

Nonstop6h 04m

$429

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 12/16

1:45 pm-5:37 pm

Nonstop6h 52m

San Diego

Mon 1/5

8:16 pm-5:20 am

Nonstop6h 04m

$429

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 12/23

4:41 pm-6:46 pm

1 stop29h 05m

San Diego

Sun 1/4

8:45 pm-2:45 pm

2 stops15h 00m

$434

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 11/27

3:35 pm-12:13 am

1 stop11h 38m

San Diego

Sat 12/6

4:08 pm-2:45 pm

2 stops19h 37m

$434

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 12/16

11:35 am-9:51 pm

1 stop13h 16m

San Diego

Mon 1/5

5:10 pm-2:45 pm

1 stop18h 35m

$434

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 11/16

1:15 pm-5:03 pm

Nonstop6h 48m

$245

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 12/17

3:46 pm-11:35 pm

1 stop10h 49m

$245

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Mon 12/22

1:45 pm-5:37 pm

Nonstop6h 52m

$245

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 12/17

1:45 pm-5:37 pm

Nonstop6h 52m

$245

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sat 11/22

8:05 am-6:20 pm

1 stop13h 15m

$250

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 15 results
1
2

Compare providers for flights from Panama City to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Diego in October.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-San Diego flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-San Diego flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-San Diego flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Diego

What is the cheapest month to book a flight from Panama City to San Diego?

Currently, November is the cheapest month in which you can book a flight from Panama City to San Diego (average of $275). Flying from Panama City to San Diego in April is currently the most expensive (average of $600). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SAN?

Find hourly flight availability from Panama City to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

It’s optimal to fly from Panama City to San Diego at noon. By choosing this option you can save up to 68% on the cost of your flight, compared to a flight in the evening.

How much does it cost to fly round-trip from Panama City to San Diego?

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated October 28, 2025.
Peruse reviews from past customers who have flown with Copa Airlines and United Airlines from Panama City to San Diego to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,560 reviews

Comfort

7.4

Boarding

7.8

Crew

8.1

Food

6.8

Overall

7.6

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,560 reviews
Copa Airlines
7.6
Good
1,560 reviews

Comfort

7.4

Boarding

7.8

Crew

8.1

Food

6.8

Overall

7.6

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
United Airlines
7.4
Good
8,996 reviews
Copa Airlines
7.6
Good
1,560 reviews

Comfort

7.4

Boarding

7.8

Crew

8.1

Food

6.8

Overall

7.6

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to San Diego?

    A quick flight from Panama City to San Diego can take about 6h 56m. Copa Airlines provides one of the quickest options available for as low as $429. Airlines will cover a distance of 2910 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City to San Diego round-trip?

    Copa Airlines, at $224, was found to be the cheapest airline from Panama City to San Diego. An alternate airline flying to your destination would be United Airlines. Users have found that Copa Airlines is 59% cheaper than the other options available to this destination.

  • What are the cheapest flights from Panama City to San Diego?

    On average you can expect to pay $481 for a flight from Panama City to San Diego. The cheapest flight overall is $270 while the most popular route, (Panama City Tocumen Intl - San Diego) is currently priced at $419.

  • Can I find deals for flights from Panama City to San Diego that include hotel bookings?

    Yes. In addition to deals on Panama City to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Diego.

  • Can I find deals for business class flights from Panama City to San Diego?

    Yes. Cheapflights offers flight deals from Panama City to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to San Diego?

    Currently, November is the cheapest month in which you can book a flight from Panama City to San Diego (average of $275). Flying from Panama City to San Diego in April is currently the most expensive (average of $600). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
Lemon Grove
National City

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Panama City to San Diego

Discover the top 2 airlines that operate flights from Panama City to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$224Average$460FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$361Average$609FlexibilityNo cancel feeOn-time69%

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