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$350+ Cheap flights from Panama City (PTY) to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/22. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SAN
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheap flight deals from Panama City to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2025.

Round-trip from

$412
(United Airlines)

One-way from

$350
(Mytrip)

Popular in

January

Cheapest in

October

Average price

$489
From Panama City Tocumen Intl to San Diego
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One-way flight from Panama City Tocumen Intl to San Diego
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Highest demand for flights based on searches. 17% potential increase in price ($124 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Panama City to San Diego

Cheapest flights from Panama City to San Diego
Explore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/153:35 pmPTY - SAN
1 stop31h 13mUnited Airlines
Sun 9/218:00 amSAN - PTY
1 stop10h 10mUnited Airlines
Deal found 7/27$412
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/193:31 pmPTY - SAN
2 stops20h 21mAmerican Airlines
Fri 9/265:15 pmSAN - PTY
2 stops19h 16mAmerican Airlines
Deal found 7/29$423
This Copa Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/121:15 pmPTY - SAN
Nonstop6h 35mCopa Airlines
Fri 9/199:08 pmSAN - PTY
Nonstop6h 17mCopa Airlines
Deal found 7/28$484
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:17 pmPTY - SAN
1 stop10h 41mDelta
Sat 1/39:50 pmSAN - PTY
1 stop13h 05mDelta
Deal found 7/28$592
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/113:20 amPTY - SAN
2 stops19h 09mMultiple Airlines
Fri 9/199:08 pmSAN - PTY
Nonstop6h 17mMultiple Airlines
Deal found 7/28$663

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

Fly from

Panama City

Fly to

San Diego

Route

Depart

Return

Price

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Mon 9/15

3:35 pm-10:24 am

1 stop20h 49m

San Diego

Sun 9/21

10:54 am-2:14 pm

2 stops25h 20m

$412

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 9/19

3:31 pm-9:52 am

2 stops20h 21m

San Diego

Fri 9/26

5:15 pm-2:31 pm

2 stops19h 16m

$423

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 9/12

1:15 pm-5:50 pm

Nonstop6h 35m

San Diego

Fri 9/19

9:08 pm-5:25 am

Nonstop6h 17m

$484

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 9/11

3:20 am-8:29 pm

2 stops19h 09m

San Diego

Fri 9/19

9:08 pm-5:25 am

Nonstop6h 17m

$663

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Mon 9/22

3:40 pm-6:42 pm

3 stops29h 02m

$350

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Mon 9/22

3:30 pm-10:13 am

2 stops20h 43m

$367

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Mon 9/22

1:15 pm-5:50 pm

Nonstop6h 35m

$436

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from Panama City to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Diego

What is the cheapest month to book a flight from Panama City to San Diego?

Currently, August is the cheapest month in which you can book a flight from Panama City to San Diego (average of $286). Flying from Panama City to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SAN?

Find hourly flight availability from Panama City to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

It’s optimal to fly from Panama City to San Diego at noon. By choosing this option you can save up to 69% on the cost of your flight, compared to a flight in the evening.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated July 29, 2025.
Peruse reviews from past customers who have flown with Copa Airlines, United Airlines, and American Airlines from Panama City to San Diego to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,493 reviews

Crew

8.1

Overall

7.5

Food

6.8

Comfort

7.4

Entertainment

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Copa Airlines
7.5
Good
1,493 reviews
Copa Airlines
7.5
Good
1,493 reviews

Crew

8.1

Overall

7.5

Food

6.8

Comfort

7.4

Entertainment

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
United Airlines
7.4
Good
8,896 reviews
Copa Airlines
7.5
Good
1,493 reviews

Crew

8.1

Overall

7.5

Food

6.8

Comfort

7.4

Entertainment

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
American Airlines
7.2
Good
10,000 reviews
Copa Airlines
7.5
Good
1,493 reviews

Crew

8.1

Overall

7.5

Food

6.8

Comfort

7.4

Entertainment

6.8

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Panama City to San Diego round-trip?

    United Airlines, at $412, was found to be the cheapest airline from Panama City to San Diego.Alternate airlines to your destination round-trip include American Airlines and Copa Airlines. Users have found that United Airlines is 30% cheaper than the other options available to this destination.

  • Can I find deals for flights from Panama City to San Diego that include hotel bookings?

    Yes. In addition to deals on Panama City to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Diego.

  • Can I find deals for business class flights from Panama City to San Diego?

    Yes. Cheapflights offers flight deals from Panama City to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Panama City to San Diego (average of $286). Flying from Panama City to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
Poway
National City
Lemon Grove
Imperial Beach
La Mesa
Alpine
Santee

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Top 2 airlines flying from Panama City to San Diego

Discover the top 2 airlines that operate flights from Panama City to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$233Average$465FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$361Average$600FlexibilityNo cancel feeOn-time69%

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