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$350+ Cheap flights from Panama to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SAN
Aug 9 — Aug 161
Sat 8/9
Sat 8/16
1 adult, Economy
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Cheap flight deals from Panama to San Diego

Keep the following information in mind while searching for Panama to San Diego flight deals. Data was last updated August 4, 2025.

Round-trip from

$406
(Copa Airlines)

One-way from

$350
(Mytrip)

Popular in

January

Cheapest in

October

Average price

$483

Good round-trip deal

$417 or less
From Panama to San Diego
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One-way flight from Panama to San Diego
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Highest demand for flights based on searches. 15% potential increase in price ($107 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Price to beat on a round-trip flight from Panama to San Diego.
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Find flight deals from Panama to San Diego

Cheapest flights from Panama to San Diego
Explore the most affordable flight options available from Panama to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2025.

This deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/297:55 amPTY - SAN
1 stop12h 29mUnited Airlines
Sun 11/98:00 amSAN - PTY
1 stop8h 38mUnited Airlines
Deal found 8/4$412
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/141:15 pmPTY - SAN
Nonstop6h 35mCopa Airlines
Sun 9/219:08 pmSAN - PTY
Nonstop6h 17mCopa Airlines
Deal found 8/4$535
This Mytrip deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/113:25 amPTY - SAN
3 stops29h 56mMultiple Airlines
Thu 8/141:17 pmSAN - PTY
3 stops33h 28mMultiple Airlines
Deal found 8/4$705
This American Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/232:43 pmPTY - SAN
1 stop23h 42mAmerican Airlines
Tue 12/167:58 pmSAN - PTY
2 stops16h 27mAmerican Airlines
Deal found 8/4$758

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2025.
Use the filters below to find and compare flights from Panama to San Diego that are best for you.

Fly from

Panama

Fly to

San Diego

Route

Depart

Return

Price

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 10/29

7:55 am-6:24 pm

1 stop12h 29m

San Diego

Sun 11/9

8:00 am-7:38 pm

1 stop8h 38m

$412

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 9/14

1:15 pm-5:50 pm

Nonstop6h 35m

San Diego

Sun 9/21

9:08 pm-5:25 am

Nonstop6h 17m

$535

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 9/18

8:10 pm-7:29 am

3 stops37h 19m

San Diego

Thu 9/25

7:47 pm-9:10 pm

3 stops23h 23m

$725

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 11/23

2:43 pm-11:25 am

1 stop23h 42m

San Diego

Tue 12/16

7:58 pm-3:25 pm

2 stops16h 27m

$758

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 8/31

8:10 pm-7:21 am

3 stops37h 11m

$350

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 8/31

3:35 pm-10:15 am

1 stop20h 40m

$402

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Mon 12/22

8:10 am-6:29 pm

1 stop13h 19m

$453

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 8/31

1:15 pm-5:44 pm

Nonstop6h 29m

$529

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 1/22

8:05 pm-5:49 pm

3 stops24h 44m

$632

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/2

Best time to book a flight from Panama to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to San Diego

What is the cheapest month to book a flight from Panama to San Diego?

Currently, August is the cheapest month in which you can book a flight from Panama to San Diego (average of $286). Flying from Panama to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to SAN?

Find hourly flight availability from Panama to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 4, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to San Diego as you normally would.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated August 4, 2025.
Peruse reviews from past customers who have flown with Copa Airlines, United Airlines, and American Airlines from Panama to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,500 reviews

Overall

7.5

Comfort

7.4

Entertainment

6.8

Crew

8.1

Boarding

7.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Copa Airlines
7.5
Good
1,500 reviews
Copa Airlines
7.5
Good
1,500 reviews

Overall

7.5

Comfort

7.4

Entertainment

6.8

Crew

8.1

Boarding

7.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
United Airlines
7.4
Good
8,912 reviews
Copa Airlines
7.5
Good
1,500 reviews

Overall

7.5

Comfort

7.4

Entertainment

6.8

Crew

8.1

Boarding

7.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
American Airlines
7.2
Good
10,000 reviews
Copa Airlines
7.5
Good
1,500 reviews

Overall

7.5

Comfort

7.4

Entertainment

6.8

Crew

8.1

Boarding

7.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Related info for your journey

Find useful and relevant information for your journey from Panama to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Panama?

    Most people fly into San Diego (SAN) if they book a flight to San Diego from Panama. San Diego is conveniently located just 2.6 mi from San Diego’s city center.

  • What are the cheapest flights from Panama to San Diego?

    Looking at all options, your cheapest flight can be booked for $319. While the most popular route (Panama City Tocumen Intl - San Diego) can be booked for $406 on average our data indicates $624 when flying from Panama to San Diego.

  • Can I find deals for flights from Panama to San Diego that include hotel bookings?

    Yes. In addition to deals on Panama to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to San Diego.

  • Can I find deals for business class flights from Panama to San Diego?

    Yes. Cheapflights offers flight deals from Panama to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Panama to San Diego (average of $286). Flying from Panama to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
Poway
National City
Lemon Grove
Imperial Beach
La Mesa
Alpine

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Alternative routes for Panama to San Diego

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Top 2 airlines flying from Panama to San Diego

Discover the top 2 airlines that operate flights from Panama to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$224Average$443FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$361Average$600FlexibilityNo cancel feeOn-time69%

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