$287+ Cheap flights from Panama to San Diego (SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SAN
May 3 — May 101
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama to San Diego
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Best
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Cheapest flights from Panama to San DiegoExplore the most affordable flight options available from Panama to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2026.
Explore the most affordable flight options available from Panama to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2026.
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/221:49 pm
PTY
- SAN
1 stop10h 39m
American Airlines
Sat 5/210:05 pm
SAN
- PTY
1 stop12h 41m
American Airlines
Deal found 3/31![American Airlines logo]()
$614
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/231:49 pm
PTY
- SAN
1 stop10h 39m
American Airlines
Sat 4/2510:05 pm
SAN
- PTY
1 stop12h 41m
American Airlines
Deal found 4/2![American Airlines logo]()
$637
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/51:49 pm
PTY
- SAN
1 stop24h 04m
American Airlines
Wed 5/2712:36 pm
SAN
- PTY
1 stop21h 38m
American Airlines
Deal found 3/31![American Airlines logo]()
$650
This Expedia deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/233:50 pm
PTY
- SAN
2 stops19h 45m
Multiple Airlines
Fri 8/79:27 pm
SAN
- PTY
3 stops26h 28m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$653
Best flights from Panama to San DiegoDiscover carefully curated flight deals from Panama to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 3, 2026.
Discover carefully curated flight deals from Panama to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 3, 2026.
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/221:49 pm
PTY
- SAN
2 stops20h 26m
American Airlines
Sat 5/27:20 pm
SAN
- PTY
2 stops15h 26m
American Airlines
Deal found 4/2![American Airlines logo]()
$652
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/223:30 pm
PTY
- SAN
1 stop30h 20m
United Airlines
Sun 7/266:55 pm
SAN
- PTY
2 stops19h 17m
United Airlines
Deal found 3/29![United Airlines logo]()
$677
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:00 am
PTY
- SAN
1 stop9h 46m
United Airlines
Sat 8/298:00 am
SAN
- PTY
1 stop8h 37m
United Airlines
Deal found 3/28![United Airlines logo]()
$686
Last-minute flights from Panama to San DiegoDiscover last-minute flight deals from Panama to San Diego. Data last updated April 3, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to San Diego. Data last updated April 3, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:30 am
PTY
- SAN
2 stops31h 41m
Multiple Airlines
Tue 4/215:31 pm
SAN
- PTY
2 stops14h 59m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$670
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/221:49 pm
PTY
- SAN
1 stop10h 39m
American Airlines
Sat 5/210:05 pm
SAN
- PTY
1 stop12h 41m
American Airlines
Deal found 3/31![American Airlines logo]()
$614
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/231:49 pm
PTY
- SAN
1 stop10h 39m
American Airlines
Sat 4/2510:05 pm
SAN
- PTY
1 stop12h 41m
American Airlines
Deal found 4/2![American Airlines logo]()
$637
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/51:49 pm
PTY
- SAN
1 stop24h 04m
American Airlines
Wed 5/2712:36 pm
SAN
- PTY
1 stop21h 38m
American Airlines
Deal found 3/31![American Airlines logo]()
$650
This Copa Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:39 pm
PTY
- SAN
Nonstop6h 51m
Copa Airlines
Sun 5/3110:00 pm
SAN
- PTY
Nonstop6h 07m
Copa Airlines
Deal found 3/30![Copa Airlines logo]()
$672
One-way flights from Panama to San DiegoSearch for one-way flight options from Panama to San Diego. Find affordable one-way fares based on user searches. Data last updated April 3, 2026.
Search for one-way flight options from Panama to San Diego. Find affordable one-way fares based on user searches. Data last updated April 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/54:25 am
PTY
- SAN
3 stops39h 34m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/313:10 pm
PTY
- SAN
3 stops29h 23m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/293:10 pm
PTY
- SAN
3 stops29h 15m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/210:10 am
PTY
- SAN
3 stops37h 02m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$361
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:10 pm
PTY
- SAN
3 stops34h 40m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/289:33 pm
PTY
- SAN
2 stops37h 09m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/39:33 pm
PTY
- SAN
3 stops37h 09m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$380
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:01 am
PTY
- SAN
3 stops33h 31m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$387
Find flight deals from Panama to San Diego
Keep the following information in mind while searching for Panama to San Diego flight deals. Data was last updated April 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $614 (American Airlines) |
One-way from | $287 (Kiwi.com) |
Popular in | February |
Cheapest in | October |
Average price | $626 |
Good one-way deal | $812 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
Use the filters below to find and compare flights from Panama to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Wed 4/22
1:49 pm-8:15 am
2 stops20h 26m
San Diego
Sat 5/2
7:20 pm-12:46 pm
2 stops15h 26m
$652
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Wed 7/22
3:30 pm-7:50 pm
1 stop30h 20m
San Diego
Sun 7/26
6:55 pm-4:12 pm
2 stops19h 17m
$677
Quickest round-trip
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Wed 8/26
10:00 am-5:46 pm
1 stop9h 46m
San Diego
Sat 8/29
8:00 am-6:37 pm
1 stop8h 37m
$686
Cheapest one-way
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Tue 5/5
5:30 am-12:48 pm
2 stops33h 18m
$369
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Tue 4/7
4:25 am-8:45 pm
2 stops18h 20m
$501
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Mon 7/27
3:30 pm-5:41 pm
1 stop28h 11m
$513
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Wed 7/22
7:55 am-7:50 pm
1 stop13h 55m
$513
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Wed 6/3
2:15 pm-11:27 pm
1 stop11h 12m
$526
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Mon 6/1
2:15 pm-11:27 pm
1 stop11h 12m
$526
Panama CitySan Diego
PTY - SAN
PTYSAN
Panama City Tocumen Intl
Sat 7/25
3:30 pm-1:21 pm
1 stop23h 51m
$540
Showing 1-10 of 12 resultsSorted by cheapest first
Best time to book a flight from Panama to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama with our price prediction graph.
PTY-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to San Diego
PA0-SAN
PTY-SAN
What is the cheapest month to book a flight from Panama to San Diego?
Currently, January is the cheapest month in which you can book a flight from Panama to San Diego (average of $234). Flying from Panama to San Diego in February is currently the most expensive (average of $645). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PA to SAN?
Find hourly flight availability from Panama to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 3, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to San Diego as you normally would.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated April 3, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and United Airlines from Panama to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Food
6.8
Boarding
7.8
Comfort
7.4
Entertainment
6.8
Overall
7.5
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Crew
8.1
Food
6.8
Boarding
7.8
Comfort
7.4
Entertainment
6.8
Overall
7.5
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Crew
8.1
Food
6.8
Boarding
7.8
Comfort
7.4
Entertainment
6.8
Overall
7.5
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Related info for your journey
Find useful and relevant information for your journey from Panama to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove
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Search flights from Panama to San Diego by cabin class
Find flights from Panama to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama and San Diego flights
Browse other Panama and San Diego flight options. Last updated on April 3, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 3, 2026.
Top 2 airlines flying from Panama to San Diego
Discover the top 2 airlines that operate flights from Panama to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$224 | Average$465 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$361 | Average$704 | FlexibilityNo cancel fee | On-time69% |