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San Diego

$283+ Cheap flights from Panama to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/26. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SAN
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
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Cheap flight deals from Panama to San Diego

Cheapest flights from Panama to San Diego
Explore the most affordable flight options available from Panama to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This Copa Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/151:15 pm
PTY
-
SAN
Nonstop6h 59m
Copa Airlines
Sun 3/229:18 pm
SAN
-
PTY
Nonstop6h 02m
Copa Airlines
Deal found 1/21$537
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:55 am
PTY
-
SAN
1 stop12h 10m
United Airlines
Sat 4/116:15 am
SAN
-
PTY
1 stop29h 59m
United Airlines
Deal found 1/20$542
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/198:55 am
PTY
-
SAN
2 stops17h 45m
United Airlines
Mon 2/237:50 pm
SAN
-
PTY
2 stops18h 17m
United Airlines
Deal found 1/19$596
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/154:41 pm
PTY
-
SAN
2 stops19h 43m
United Airlines
Fri 2/206:10 pm
SAN
-
PTY
2 stops22h 28m
United Airlines
Deal found 1/21$628
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/157:55 am
PTY
-
SAN
1 stop16h 05m
United Airlines
Sun 3/225:50 pm
SAN
-
PTY
1 stop17h 55m
United Airlines
Deal found 1/21$658
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/138:55 am
PTY
-
SAN
1 stop31h 52m
United Airlines
Tue 2/176:15 am
SAN
-
PTY
2 stops29h 30m
United Airlines
Deal found 1/21$660
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/19:45 am
PTY
-
SAN
3 stops31h 12m
Multiple Airlines
Mon 2/98:17 pm
SAN
-
PTY
Nonstop6h 03m
Multiple Airlines
Deal found 1/20$674
This United Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/58:55 am
PTY
-
SAN
2 stops17h 45m
United Airlines
Thu 3/1210:30 am
SAN
-
PTY
1 stop27h 37m
United Airlines
Deal found 1/18$676
This Kiwi.com deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/710:26 am
PTY
-
SAN
1 stop11h 35m
Multiple Airlines
Sat 3/145:42 pm
SAN
-
PTY
2 stops37h 08m
Multiple Airlines
Deal found 1/21$687
This Orbitz deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/305:30 am
PTY
-
SAN
2 stops17h 15m
Multiple Airlines
Sat 4/410:02 pm
SAN
-
PTY
2 stops34h 28m
Multiple Airlines
Deal found 1/20$689
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:35 pm
PTY
-
SAN
1 stop22h 50m
American Airlines
Sat 11/712:25 pm
SAN
-
PTY
1 stop22h 11m
American Airlines
Deal found 1/20$695

Find flight deals from Panama to San Diego

Keep the following information in mind while searching for Panama to San Diego flight deals. Data was last updated January 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$537
(Copa Airlines)

One-way from

$283
(Kiwi.com)

Popular in

February

Cheapest in

October

Average price

$704

Good one-way deal

$244 or less
Provider with most accurate pricing for Panama City Tocumen Intl-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-San Diego flights.
Search Deals
From Panama to San Diego
Search Deals
One-way flight from Panama to San Diego
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($138 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a one-way flight from Panama to San Diego.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Panama to San Diego that are best for you.

Fly from

Panama

Fly to

San Diego

Route

Depart

Return

Price

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 4/8

10:00 am-8:05 pm

1 stop12h 05m

San Diego

Sat 4/11

12:10 pm-4:12 pm

1 stop26h 02m

$542

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 4/2

10:00 am-9:26 pm

1 stop13h 26m

San Diego

Sun 4/5

6:15 am-6:37 pm

1 stop10h 22m

$542

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 2/19

8:55 am-11:40 pm

2 stops17h 45m

San Diego

Mon 2/23

4:00 pm-2:45 pm

2 stops19h 45m

$596

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 2/15

4:41 pm-1:47 pm

1 stop24h 06m

San Diego

Fri 2/20

6:10 pm-2:45 pm

2 stops17h 35m

$628

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 4/26

3:20 am-11:30 am

2 stops34h 10m

$283

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 2/17

5:50 pm-1:43 pm

3 stops46h 53m

$332

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 4/3

5:30 am-9:35 pm

3 stops42h 05m

$339

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sat 4/4

10:05 pm-8:09 pm

3 stops48h 04m

$367

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sat 4/4

3:20 am-8:26 pm

3 stops43h 06m

$377

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 5/3

10:05 pm-6:34 pm

3 stops22h 29m

$393

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 13 results
1
2

Best time to book a flight from Panama to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to San Diego

What is the cheapest month to book a flight from Panama to San Diego?

Currently, December is the cheapest month in which you can book a flight from Panama to San Diego (average of $246). Flying from Panama to San Diego in February is currently the most expensive (average of $603). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to SAN?

Find hourly flight availability from Panama to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 21, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to San Diego as you normally would.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated January 21, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and United Airlines from Panama to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,557 reviews

Overall

7.6

Crew

8.1

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.6
Good
1,557 reviews
Copa Airlines
7.6
Good
1,557 reviews

Overall

7.6

Crew

8.1

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
United Airlines
7.4
Good
9,191 reviews
Copa Airlines
7.6
Good
1,557 reviews

Overall

7.6

Crew

8.1

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Panama to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Panama?

    Most people fly into San Diego (SAN) if they book a flight to San Diego from Panama. San Diego is conveniently located just 2.6 mi from San Diego’s city center.

  • How long is the flight from Panama to San Diego?

    Airlines like United Airlines fly from Panama to San Diego in about 12h 05m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 2910 mi.

  • What are the cheapest airlines to fly from Panama to San Diego one-way?

    One-way options have recently been found by users for as low as $224 on Copa Airlines. Other airlines that offer cheap prices include United Airlines from $347 and Delta from $362 one-way.

  • What are the cheapest flights from Panama to San Diego?

    Looking at all options, your cheapest flight can be booked for $244. While the most popular route (Panama City Tocumen Intl - San Diego) can be booked for $528 on average, our data indicates $244 when flying from Panama to San Diego.

  • Can I find deals for flights from Panama to San Diego that include hotel bookings?

    Yes. In addition to deals on Panama to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to San Diego.

  • Can I find deals for business class flights from Panama to San Diego?

    Yes. Cheapflights offers flight deals from Panama to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to San Diego?

    Currently, December is the cheapest month in which you can book a flight from Panama to San Diego (average of $246). Flying from Panama to San Diego in February is currently the most expensive (average of $603). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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Alternative routes for Panama to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Panama to San Diego

Discover the top 2 airlines that operate flights from Panama to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$224Average$443FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$361Average$620FlexibilityNo cancel feeOn-time69%

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