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San Diego

$245+ Cheap flights from Panama to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SAN
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Cheap flight deals from Panama to San Diego

Keep the following information in mind while searching for Panama to San Diego flight deals. Data was last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$429
(Copa Airlines)

One-way from

$245
(Copa Airlines)

Popular in

January

Cheapest in

October

Average price

$372

Good one-way deal

$501 or less
Provider with most accurate pricing for Panama City Tocumen Intl-San Diego flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-San Diego flights.
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From Panama to San Diego
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One-way flight from Panama to San Diego
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Highest demand for flights based on searches. 20% potential increase in price ($139 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Price to beat on a one-way flight from Panama to San Diego.
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Find flight deals from Panama to San Diego

Cheapest flights from Panama to San Diego
Explore the most affordable flight options available from Panama to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Copa Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/291:15 pmPTY - SAN
Nonstop6h 42mCopa Airlines
Mon 11/38:10 pmSAN - PTY
Nonstop6h 10mCopa Airlines
Deal found 10/15$429
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/53:21 pmPTY - SAN
1 stop10h 53mDelta
Mon 11/1010:30 pmSAN - PTY
1 stop12h 42mDelta
Deal found 10/16$434
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/52:49 pmPTY - SAN
2 stops20h 58mAmerican Airlines
Mon 11/104:25 pmSAN - PTY
2 stops18h 24mAmerican Airlines
Deal found 10/15$455
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/291:15 pmPTY - SAN
Nonstop6h 42mMultiple Airlines
Mon 11/36:25 amSAN - PTY
3 stops23h 25mMultiple Airlines
Deal found 10/15$535
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/293:15 pmPTY - SAN
2 stops21h 30mAmerican Airlines
Mon 11/34:25 pmSAN - PTY
2 stops18h 24mAmerican Airlines
Deal found 10/15$550
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/264:55 pmPTY - SAN
2 stops18h 53mAmerican Airlines
Mon 1/261:19 pmSAN - PTY
2 stops21h 08mAmerican Airlines
Deal found 10/16$555
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/58:55 amPTY - SAN
2 stops14h 59mUnited Airlines
Mon 11/105:55 pmSAN - PTY
3 stops17h 50mUnited Airlines
Deal found 10/15$563
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/223:15 pmPTY - SAN
1 stop22h 11mAmerican Airlines
Wed 1/1410:25 pmSAN - PTY
1 stop12h 02mAmerican Airlines
Deal found 10/15$575
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/164:43 pmPTY - SAN
2 stops18h 45mAmerican Airlines
Mon 1/52:23 pmSAN - PTY
2 stops20h 04mAmerican Airlines
Deal found 10/15$587

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Panama to San Diego that are best for you.

Fly from

Panama

Fly to

San Diego

Route

Depart

Return

Price

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 12/26

1:45 pm-5:37 pm

Nonstop6h 52m

San Diego

Mon 1/26

8:16 pm-5:20 am

Nonstop6h 04m

$429

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 10/29

1:15 pm-5:57 pm

Nonstop6h 42m

San Diego

Mon 11/3

8:10 pm-5:20 am

Nonstop6h 10m

$429

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 11/5

1:15 pm-5:03 pm

Nonstop6h 48m

San Diego

Mon 11/10

8:10 pm-5:20 am

Nonstop6h 10m

$429

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 12/16

1:45 pm-5:37 pm

Nonstop6h 52m

San Diego

Mon 1/5

8:16 pm-5:20 am

Nonstop6h 04m

$429

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 11/5

3:21 pm-11:14 pm

1 stop10h 53m

San Diego

Mon 11/10

9:50 pm-2:12 pm

1 stop13h 22m

$434

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 10/29

2:21 pm-11:14 pm

1 stop10h 53m

San Diego

Mon 11/3

10:30 pm-1:56 pm

1 stop12h 26m

$434

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 11/5

2:49 pm-8:47 am

2 stops20h 58m

San Diego

Mon 11/10

4:25 pm-1:49 pm

2 stops18h 24m

$455

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 12/26

4:55 pm-8:48 am

2 stops18h 53m

San Diego

Mon 1/26

1:19 pm-1:27 pm

2 stops21h 08m

$555

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 12/16

4:43 pm-8:28 am

2 stops18h 45m

San Diego

Mon 1/5

2:23 pm-1:27 pm

2 stops20h 04m

$587

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 12/7

1:45 pm-5:37 pm

Nonstop6h 52m

$245

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/16

Showing 1-10 of 18 results
1
2

Best time to book a flight from Panama to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to San Diego

What is the cheapest month to book a flight from Panama to San Diego?

Currently, November is the cheapest month in which you can book a flight from Panama to San Diego (average of $270). Flying from Panama to San Diego in April is currently the most expensive (average of $600). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to SAN?

Find hourly flight availability from Panama to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 70% on flights from Panama to San Diego by exploring options for tickets at noon.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated October 16, 2025.
Peruse reviews from past customers who have flown with Copa Airlines and United Airlines from Panama to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,551 reviews

Overall

7.6

Comfort

7.4

Food

6.8

Boarding

7.8

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,551 reviews
Copa Airlines
7.6
Good
1,551 reviews

Overall

7.6

Comfort

7.4

Food

6.8

Boarding

7.8

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
United Airlines
7.4
Good
8,982 reviews
Copa Airlines
7.6
Good
1,551 reviews

Overall

7.6

Comfort

7.4

Food

6.8

Boarding

7.8

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Panama?

    Most people fly into San Diego (SAN) if they book a flight to San Diego from Panama. San Diego is conveniently located just 2.6 mi from San Diego’s city center.

  • How long is the flight from Panama to San Diego?

    Airlines like Copa Airlines and Delta fly from Panama to San Diego in about 6h 52m. The time it takes to get you to your destination can typically vary by up to 4h 01m. Airlines will cover a distance of 2910 mi. This flight may include one or multiple stops.

  • What are the cheapest flights from Panama to San Diego?

    Looking at all options, your cheapest flight can be booked for $501. While the most popular route (Panama City Tocumen Intl - San Diego) can be booked for $423 on average, our data indicates $1,048 when flying from Panama to San Diego.

  • Can I find deals for flights from Panama to San Diego that include hotel bookings?

    Yes. In addition to deals on Panama to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to San Diego.

  • Can I find deals for business class flights from Panama to San Diego?

    Yes. Cheapflights offers flight deals from Panama to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to San Diego?

    Currently, November is the cheapest month in which you can book a flight from Panama to San Diego (average of $270). Flying from Panama to San Diego in April is currently the most expensive (average of $600). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
Lemon Grove
Imperial Beach
National City

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Alternative routes for Panama to San Diego

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Top 2 airlines flying from Panama to San Diego

Discover the top 2 airlines that operate flights from Panama to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$224Average$443FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$361Average$600FlexibilityNo cancel feeOn-time69%

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