$169+ Cheap flights from Mississippi to San Diego (SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/24. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — SAN
Dec 4 — Dec 111
Round-trip
1 adult, Economy
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Find cheap flights from Mississippi to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mississippi to San Diego
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Cheapest flights from Mississippi to San DiegoExplore the most affordable flight options available from Mississippi to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
Explore the most affordable flight options available from Mississippi to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:14 am -
1 stop7h 16m
Tue 12/158:00 am -
1 stop6h 24m
Deal found 10/31![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/81:55 pm -
2 stops8h 13m
Tue 12/158:00 am -
1 stop6h 34m
Deal found 10/31![United Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:21 pm -
1 stop6h 35m
Sat 12/1212:29 pm -
1 stop8h 43m
Deal found 11/3![American Airlines logo]()
$368
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:15 pm -
1 stop5h 55m
Sat 12/127:15 am -
2 stops9h 55m
Deal found 11/3![Southwest logo]()
$373
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:21 pm -
1 stop6h 35m
Sun 12/611:13 am -
1 stop5h 38m
Deal found 10/31![American Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:21 pm -
1 stop6h 35m
Sun 12/63:13 pm -
1 stop5h 49m
Deal found 11/4![American Airlines logo]()
$384
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:21 pm -
1 stop7h 35m
Tue 12/12:18 pm -
1 stop6h 57m
Deal found 11/2![American Airlines logo]()
$393
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:23 am -
1 stop8h 18m
Wed 11/188:00 am -
1 stop6h 22m
Deal found 10/30![American Airlines logo]()
$403
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:05 am -
2 stops10h 12m
Wed 11/1812:05 pm -
1 stop6h 21m
Deal found 10/30![United Airlines logo]()
$408
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/184:55 pm -
1 stop6h 31m
Sun 11/228:05 am -
1 stop6h 03m
Deal found 11/3![United Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/305:25 am -
1 stop6h 51m
Wed 1/611:20 am -
1 stop8h 36m
Deal found 10/30![American Airlines logo]()
$487
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1510:00 am -
2 stops31h 57m
Thu 11/198:20 pm -
1 stop19h 46m
Deal found 10/30![Multiple Airlines logo]()
$510
Best flights from Mississippi to San DiegoDiscover carefully curated flight deals from Mississippi to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
Discover carefully curated flight deals from Mississippi to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/612:09 pm -
1 stop9h 02m
Wed 1/1312:29 pm -
1 stop8h 22m
Deal found 11/3![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:15 pm -
1 stop5h 55m
Sat 12/127:15 am -
2 stops9h 55m
Deal found 11/3![Southwest logo]()
$373
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:11 pm -
1 stop8h 27m
Sun 12/66:20 am -
1 stop6h 41m
Deal found 11/1![Delta logo]()
$379
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/201:59 pm -
2 stops12h 20m
Sun 1/248:00 am -
1 stop6h 05m
Deal found 10/31![United Airlines logo]()
$384
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:05 am -
2 stops10h 12m
Wed 11/1812:05 pm -
1 stop6h 21m
Deal found 10/30![United Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/305:25 am -
1 stop6h 51m
Wed 1/611:20 am -
1 stop8h 36m
Deal found 10/30![American Airlines logo]()
$487
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/85:25 pm -
1 stop6h 07m
Wed 12/91:20 pm -
1 stop6h 21m
Deal found 11/1![United Airlines logo]()
$457
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/308:15 pm -
1 stop5h 40m
Sun 1/38:35 am -
2 stops11h 50m
Deal found 11/2![Southwest logo]()
$519
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/184:55 pm -
1 stop6h 31m
Sun 11/228:05 am -
1 stop6h 03m
Deal found 11/3![United Airlines logo]()
$473
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/234:55 pm -
1 stop6h 39m
Wed 1/278:00 am -
1 stop6h 05m
Deal found 11/1![United Airlines logo]()
$499
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/64:55 pm -
1 stop6h 39m
Sat 1/911:26 am -
1 stop6h 07m
Deal found 10/31![United Airlines logo]()
$499
Last-minute flights from Mississippi to San DiegoDiscover last-minute flight deals from Mississippi to San Diego. Data last updated November 4, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to San Diego. Data last updated November 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:23 am -
1 stop8h 18m
Wed 11/188:00 am -
1 stop6h 22m
Deal found 10/30![American Airlines logo]()
$403
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:05 am -
2 stops10h 12m
Wed 11/1812:05 pm -
1 stop6h 21m
Deal found 10/30![United Airlines logo]()
$408
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1510:00 am -
2 stops31h 57m
Thu 11/198:20 pm -
1 stop19h 46m
Deal found 10/30![Multiple Airlines logo]()
$510
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:21 pm -
1 stop7h 35m
Tue 12/12:18 pm -
1 stop6h 57m
Deal found 11/2![American Airlines logo]()
$393
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/184:55 pm -
1 stop6h 31m
Sun 11/228:05 am -
1 stop6h 03m
Deal found 11/3![United Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:21 pm -
1 stop6h 35m
Sat 12/1212:29 pm -
1 stop8h 43m
Deal found 11/3![American Airlines logo]()
$368
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:15 pm -
1 stop5h 55m
Sat 12/127:15 am -
2 stops9h 55m
Deal found 11/3![Southwest logo]()
$373
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:21 pm -
1 stop6h 35m
Sun 12/611:13 am -
1 stop5h 38m
Deal found 10/31![American Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:21 pm -
1 stop6h 35m
Sun 12/63:13 pm -
1 stop5h 49m
Deal found 11/4![American Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:14 am -
1 stop7h 16m
Tue 12/158:00 am -
1 stop6h 24m
Deal found 10/31![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/81:55 pm -
2 stops8h 13m
Tue 12/158:00 am -
1 stop6h 34m
Deal found 10/31![United Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/305:25 am -
1 stop6h 51m
Wed 1/611:20 am -
1 stop8h 36m
Deal found 10/30![American Airlines logo]()
$487
One-way flights from Mississippi to San DiegoSearch for one-way flight options from Mississippi to San Diego. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
Search for one-way flight options from Mississippi to San Diego. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:01 pm -
1 stop6h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$169
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/13:48 pm -
1 stop9h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Delta logo]()
$200
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/246:00 pm -
1 stop7h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Delta logo]()
$204
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/92:44 pm -
1 stop8h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Delta logo]()
$213
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:30 am -
2 stops9h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Southwest logo]()
$216
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/252:15 pm -
1 stop9h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Delta logo]()
$230
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/247:00 am -
2 stops12h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![United Airlines logo]()
$247
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:54 pm -
2 stops8h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![United Airlines logo]()
$258
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/241:57 pm -
2 stops9h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![United Airlines logo]()
$290
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:00 am -
1 stop8h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![United Airlines logo]()
$301
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/251:54 pm -
2 stops12h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![United Airlines logo]()
$318
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:50 am -
1 stop8h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![United Airlines logo]()
$319
Find flight deals from Mississippi to San Diego
Keep the following information in mind while searching for Mississippi to San Diego flight deals. Data was last updated November 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $337 (Delta) |
One-way from | $169 (American Airlines) |
Popular in | May |
Cheapest in | August |
Average price | $476 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
Use the filters below to find and compare flights from Mississippi to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
JacksonSan Diego
JAN Jackson-Evers Intl - SAN San Diego
JANSAN
Jackson-Evers Intl
Tue 11/24
5:01 pm-9:55 pm
1 stop6h 54m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$169
JacksonSan Diego
JAN Jackson-Evers Intl - SAN San Diego
JANSAN
Jackson-Evers Intl
Tue 12/1
3:48 pm-11:38 pm
1 stop9h 50m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$200
GulfportSan Diego
GPT Gulfport Biloxi Regional - SAN San Diego
GPTSAN
Gulfport Biloxi Regional
Wed 11/18
6:21 pm-11:56 pm
1 stop7h 35m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$204
ColumbusSan Diego
GTR Columbus Golden Triangle Reg. - SAN San Diego
GTRSAN
Columbus Golden Triangle Reg.
Wed 12/9
2:44 pm-9:19 pm
1 stop8h 35m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$213
GulfportSan Diego
GPT Gulfport Biloxi Regional - SAN San Diego
GPTSAN
Gulfport Biloxi Regional
Wed 11/18
1:54 pm-8:24 pm
2 stops8h 30m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$258
JacksonSan Diego
JAN Jackson-Evers Intl - SAN San Diego
JANSAN
Jackson-Evers Intl
Tue 11/24
1:57 pm-9:00 pm
2 stops9h 03m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$290
GulfportSan Diego
GPT Gulfport Biloxi Regional - SAN San Diego
GPTSAN
Gulfport Biloxi Regional
Wed 11/11
7:00 am-6:37 pm
2 stops13h 37m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$306
JacksonSan Diego
JAN Jackson-Evers Intl - SAN San Diego
JANSAN
Jackson-Evers Intl
Mon 11/23
6:50 am-1:24 pm
1 stop8h 34m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$319
JacksonSan Diego
JAN Jackson-Evers Intl - SAN San Diego
JANSAN
Jackson-Evers Intl
Wed 1/6
12:09 pm-7:11 pm
1 stop9h 02m
San Diego
Wed 1/13
12:29 pm-10:51 pm
1 stop8h 22m
$337
JacksonSan Diego
JAN Jackson-Evers Intl - SAN San Diego
JANSAN
Jackson-Evers Intl
Wed 12/2
6:15 pm-10:10 pm
1 stop5h 55m
San Diego
Sat 12/12
7:15 am-7:10 pm
2 stops9h 55m
$373
Showing 1-10 of 23 resultsSorted by cheapest first
Best time to book a flight from Mississippi to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Mississippi with our price prediction graph.
JAN-SAN
GPT-SAN
GTR-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to San Diego
USMS-SAN
JAN-SAN
GPT-SAN
GTR-SAN
What is the cheapest month to book a flight from Mississippi to San Diego?
Currently, January is the cheapest month in which you can book a flight from Mississippi to San Diego (average of $278). Flying from Mississippi to San Diego in June is currently the most expensive (average of $701). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Mississippi to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
San Ysidro
Poway
Coronado
La Mesa
Julian
Santee
Lemon Grove
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Mississippi to San Diego
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Diego by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mississippi to San Diego by cabin class
Find flights from Mississippi to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mississippi and San Diego flights
Browse other Mississippi and San Diego flight options. Last updated on November 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 4, 2026.
Mississippi to San Diego flights
Consider these flights traveling from Mississippi to San Diego.
Top 4 airlines flying from Mississippi to San Diego
Discover the top 4 airlines that operate flights from Mississippi to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$196 | Average$504 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$285 | Average$512 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$328 | Average$503 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$358 | Average$493 | FlexibilityNo cancel fee | On-time63% |