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$42+ Cheap flights from Mesa, AZ to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — SAN
Oct 14 — Oct 211
Tue 10/14
Tue 10/21
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to San Diego are usually found in February or October, booked 80 days in advance, depart on a Saturday or Friday and return on a Friday

Cheap flight deals from Mesa to San Diego

Keep the following information in mind while searching for Mesa to San Diego flight deals. Data was last updated September 14, 2025.

Round-trip from

$72
(Kiwi.com)

One-way from

$42
(Southwest)

Popular in

April

Cheapest in

February

Average price

$129
From Mesa to San Diego
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One-way flight from Mesa to San Diego
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Highest demand for flights based on searches. 16% potential increase in price ($25 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($3 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Mesa to San Diego

Cheapest flights from Mesa to San Diego
Explore the most affordable flight options available from Mesa to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/812:06 pmPHX - SAN
Nonstop1h 20mFrontier
Fri 10/108:11 amSAN - PHX
Nonstop1h 28mFrontier
Deal found 9/13$72
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/248:00 amPHX - SAN
Nonstop1h 26mFrontier
Tue 9/3010:16 amSAN - PHX
Nonstop1h 34mFrontier
Deal found 9/12$73
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/222:46 pmPHX - SAN
Nonstop1h 17mFrontier
Thu 9/257:54 pmSAN - PHX
Nonstop1h 30mFrontier
Deal found 9/12$74
This Cheapflightsfares deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/25:49 pmPHX - SAN
Nonstop1h 17mFrontier
Mon 10/62:31 pmSAN - PHX
Nonstop1h 28mFrontier
Deal found 9/12$75
This Cheapflightsfares deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/48:00 amPHX - SAN
Nonstop1h 26mFrontier
Sun 10/57:30 pmSAN - PHX
Nonstop1h 30mFrontier
Deal found 9/12$76
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/86:00 amPHX - SAN
Nonstop1h 20mSouthwest
Sat 10/117:50 amSAN - PHX
1 stop5h 45mSouthwest
Deal found 9/12$77
This Frontier deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:05 amPHX - SAN
Nonstop1h 21mFrontier
Sun 10/268:11 amSAN - PHX
Nonstop1h 28mFrontier
Deal found 9/12$78
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/292:46 pmPHX - SAN
Nonstop1h 17mFrontier
Thu 10/98:11 amSAN - PHX
Nonstop1h 28mFrontier
Deal found 9/13$79
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/68:40 pmPHX - SAN
Nonstop1h 15mSouthwest
Tue 10/78:50 amSAN - PHX
1 stop4h 25mSouthwest
Deal found 9/12$80
This Trip.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:05 amPHX - SAN
Nonstop1h 21mMultiple Airlines
Mon 10/208:18 amSAN - PHX
Nonstop1h 26mMultiple Airlines
Deal found 9/12$81
This Frontier deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/39:20 amPHX - SAN
Nonstop1h 22mFrontier
Fri 10/32:31 pmSAN - PHX
Nonstop1h 28mFrontier
Deal found 9/12$82
This Cheapflightsfares deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/106:05 amPHX - SAN
Nonstop1h 21mFrontier
Sun 10/128:11 amSAN - PHX
Nonstop1h 28mFrontier
Deal found 9/12$83

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 14, 2025.
Use the filters below to find and compare flights from Mesa to San Diego that are best for you.

Fly from

Mesa

Fly to

San Diego

Route

Depart

Return

Price

PhoenixSan Diego

PHX - SAN

PHXSAN

Phoenix Sky Harbor Intl

Thu 10/16

11:57 am-1:15 pm

Nonstop1h 18m

San Diego

Tue 10/21

2:11 pm-3:41 pm

Nonstop1h 30m

$80

PhoenixSan Diego

PHX - SAN

PHXSAN

Phoenix Sky Harbor Intl

Thu 11/6

6:50 am-7:05 am

Nonstop1h 15m

San Diego

Sun 11/9

6:30 am-9:00 am

Nonstop1h 30m

$84

PhoenixSan Diego

PHX - SAN

PHXSAN

Phoenix Sky Harbor Intl

Sat 10/25

11:25 am-12:40 pm

Nonstop1h 15m

San Diego

Sun 11/2

5:30 am-8:00 am

Nonstop1h 30m

$84

PhoenixSan Diego

PHX - SAN

PHXSAN

Phoenix Sky Harbor Intl

Fri 10/3

10:05 pm-11:15 pm

Nonstop1h 10m

San Diego

Tue 10/7

3:35 pm-8:10 pm

1 stop4h 35m

$84

PhoenixSan Diego

PHX - SAN

PHXSAN

Phoenix Sky Harbor Intl

Fri 10/31

6:35 am-7:50 am

Nonstop1h 15m

San Diego

Sun 11/2

5:30 am-8:00 am

Nonstop1h 30m

$90

PhoenixSan Diego

PHX - SAN

PHXSAN

Phoenix Sky Harbor Intl

Sat 10/18

4:17 pm-5:34 pm

Nonstop1h 17m

San Diego

Sat 10/18

9:14 pm-10:39 pm

Nonstop1h 25m

$92

PhoenixSan Diego

PHX - SAN

PHXSAN

Phoenix Sky Harbor Intl

Thu 10/9

8:40 pm-9:55 pm

Nonstop1h 15m

San Diego

Sat 10/11

7:50 am-1:35 pm

1 stop5h 45m

$94

PhoenixSan Diego

PHX - SAN

PHXSAN

Phoenix Sky Harbor Intl

Fri 10/24

8:40 pm-9:55 pm

Nonstop1h 15m

San Diego

Sun 10/26

7:55 pm-11:15 pm

1 stop3h 20m

$97

PhoenixSan Diego

PHX - SAN

PHXSAN

Phoenix Sky Harbor Intl

Fri 11/21

8:00 pm-8:15 pm

Nonstop1h 15m

San Diego

Sun 11/23

5:45 pm-8:10 pm

Nonstop1h 25m

$97

PhoenixSan Diego

PHX - SAN

PHXSAN

Phoenix Sky Harbor Intl

Mon 10/27

6:10 am-10:25 am

1 stop4h 15m

San Diego

Sun 11/2

5:30 am-8:00 am

Nonstop1h 30m

$97

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Showing 1-10 of 22 results
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Best time to book a flight from Mesa to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to San Diego

How far ahead should I book a flight from Mesa to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to San Diego. Price data was last updated on September 12, 2025.

Booking 80 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mesa to San Diego. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mesa to San Diego?

Currently, August is the cheapest month in which you can book a flight from Mesa to San Diego (average of $286). Flying from Mesa to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to SAN?

Find hourly flight availability from Mesa to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 14, 2025.

When flying from Mesa to San Diego, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Mesa to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Mesa to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Mesa to San Diego flight should consider departing on Saturday afternoons when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Mesa to San Diego

Explore weekly flight availability from Mesa to San Diego. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 14, 2025.

The most flights from MS9 to SAN are scheduled on a Monday (25 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (12 on average).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated September 14, 2025.
Peruse reviews from past customers who have flown with Alaska Airlines, Southwest, and Hawaiian Airlines from Mesa to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Food

7.1

Entertainment

7.0

Boarding

8.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Food

7.1

Entertainment

7.0

Boarding

8.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Southwest
8.0
Very good
4,245 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Food

7.1

Entertainment

7.0

Boarding

8.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Hawaiian Airlines
7.8
Good
2,723 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Food

7.1

Entertainment

7.0

Boarding

8.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Food

7.1

Entertainment

7.0

Boarding

8.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Frontier
5.8
Fair
3,173 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Food

7.1

Entertainment

7.0

Boarding

8.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.

Related info for your journey

Find useful and relevant information for your journey from Mesa to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Mesa?

    Located just 2.6 mi from the city center, San Diego is the airport most travelers will use when flying to San Diego from Mesa. Booking flights from Mesa to San Diego (SAN) should be relatively easy as there are 20 daily inbound flights from Mesa from 7 different airlines.

  • How long is the flight from Mesa to San Diego?

    Southwest can get you from Mesa to San Diego in just under 1h 15m. Your travel time will be generally consistent. The distance between Mesa and San Diego is about 305 mi. Generally, flights for this route are nonstop.

  • What are the most reliable airlines from Mesa to San Diego?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mesa to San Diego on time: Japan Airlines (80%), Southwest (80%), Hawaiian Airlines (79%).

  • What are the cheapest flights from Mesa to San Diego?

    While on average a flight from Mesa to San Diego is generally $537, our data shows the cheapest flight currently is $46. When looking at the most popular route, (Phoenix Sky Harbor Intl - San Diego), you can expect to pay $67 for that flight.

  • Can I find deals for flights from Mesa to San Diego that include hotel bookings?

    Yes. In addition to deals on Mesa to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to San Diego.

  • Can I find deals for business class flights from Mesa to San Diego?

    Yes. Cheapflights offers flight deals from Mesa to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Mesa to San Diego (average of $286). Flying from Mesa to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
La Mesa
Poway
Lemon Grove
Coronado
Imperial Beach
National City
Alpine

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Top 7 airlines flying from Mesa to San Diego

Discover the top 7 airlines that operate flights from Mesa to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$47Average$127FlexibilityNo cancel feeOn-time65%
FrontierCheapest$49Average$149FlexibilityNo cancel feeOn-time62%
Hawaiian AirlinesCheapest$58Average$152FlexibilityNo cancel feeOn-time85%
SouthwestCheapest$97Average$235FlexibilityNo cancel feeOn-time63%
Alaska AirlinesCheapest$97Average$152FlexibilityNo cancel feeOn-time75%
American AirlinesCheapest$117Average$248FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$269Average$404FlexibilityNo cancel feeOn-time69%

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