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$174+ Cheap flights from South Carolina to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from South Carolina to Panama

Cheapest flights from South Carolina to Panama
Explore the most affordable flight options available from South Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:50 am
CHS
-
PTY
1 stop9h 30m
American Airlines
Wed 9/23:20 pm
PTY
-
CHS
1 stop7h 56m
American Airlines
Deal found 1/27$391
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:15 am
CHS
-
PTY
1 stop8h 47m
United Airlines
Mon 3/24:41 pm
PTY
-
CHS
1 stop23h 32m
United Airlines
Deal found 1/28$399
This Avianca Connect deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:00 am
CLT
-
PTY
2 stops17h 40m
Multiple Airlines
Fri 3/62:55 pm
PTY
-
CLT
2 stops21h 25m
Multiple Airlines
Deal found 1/28$414
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/146:37 pm
CHS
-
PTY
2 stops19h 03m
American Airlines
Tue 3/171:40 pm
PTY
-
CHS
2 stops19h 37m
American Airlines
Deal found 1/29$415
This Avianca Connect deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/127:00 am
CLT
-
PTY
2 stops19h 00m
Multiple Airlines
Mon 3/162:55 pm
PTY
-
CLT
2 stops20h 24m
Multiple Airlines
Deal found 1/28$416
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:37 pm
GSP
-
PTY
2 stops18h 03m
American Airlines
Wed 4/291:49 pm
PTY
-
GSP
1 stop9h 08m
American Airlines
Deal found 1/28$417
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/107:00 am
GSP
-
PTY
1 stop8h 14m
United Airlines
Wed 8/123:20 pm
PTY
-
GSP
1 stop22h 58m
United Airlines
Deal found 1/28$421
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:03 am
CHS
-
PTY
1 stop9h 28m
United Airlines
Sun 6/710:55 pm
PTY
-
CHS
1 stop8h 59m
United Airlines
Deal found 1/28$424
This Avianca Connect deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:00 am
CLT
-
PTY
2 stops17h 40m
Multiple Airlines
Sun 3/15:50 pm
PTY
-
CLT
2 stops18h 30m
Multiple Airlines
Deal found 1/28$430
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/265:20 am
CHS
-
PTY
1 stop8h 42m
Delta
Sat 5/22:27 pm
PTY
-
CHS
1 stop8h 23m
Delta
Deal found 1/26$431
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/266:00 am
CHS
-
PTY
1 stop7h 36m
American Airlines
Sat 5/21:49 pm
PTY
-
CHS
2 stops20h 49m
American Airlines
Deal found 1/26$435
This Mytrip deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/39:07 pm
CLT
-
PTY
2 stops19h 48m
Multiple Airlines
Mon 2/95:50 pm
PTY
-
CLT
2 stops26h 22m
Multiple Airlines
Deal found 1/27$438

Find flight deals from South Carolina to Panama

Keep the following information in mind while searching for South Carolina to Panama flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$399
(United Airlines)

One-way from

$174
(United Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
Search Deals
From South Carolina to Panama
Search Deals
One-way flight from South Carolina to Panama
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from South Carolina to Panama that are best for you.

Fly from

South Carolina

Fly to

Panama

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 2/26

11:15 am-8:02 pm

1 stop8h 47m

Panama City Tocumen Intl

Mon 3/2

4:41 pm-4:13 pm

1 stop23h 32m

$399

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 3/14

6:45 pm-2:20 pm

2 stops20h 35m

Panama City Tocumen Intl

Tue 3/17

1:40 pm-11:16 am

2 stops20h 36m

$415

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 3/2

7:37 pm-1:40 pm

2 stops18h 03m

Panama City Tocumen Intl

Wed 4/29

1:49 pm-11:57 pm

1 stop9h 08m

$417

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 6/2

11:03 am-7:31 pm

1 stop9h 28m

Panama City Tocumen Intl

Sun 6/7

10:55 pm-8:54 am

1 stop8h 59m

$424

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sun 4/26

5:20 am-1:02 pm

1 stop8h 42m

Panama City Tocumen Intl

Sat 5/2

2:27 pm-11:50 pm

1 stop8h 23m

$431

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 3/3

7:00 am-1:00 am

2 stops18h 00m

Panama City Tocumen Intl

Tue 3/10

2:55 pm-12:20 pm

2 stops20h 25m

$440

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 2/23

6:53 pm-1:40 pm

2 stops18h 47m

Panama City Tocumen Intl

Mon 3/2

2:40 pm-10:42 am

2 stops20h 02m

$441

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 3/18

6:00 am-12:40 am

2 stops19h 40m

Panama City Tocumen Intl

Mon 3/30

3:25 am-8:23 pm

2 stops15h 58m

$443

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 3/5

7:00 am-1:00 am

2 stops18h 00m

Panama City Tocumen Intl

Sun 3/8

5:50 pm-12:20 pm

2 stops17h 30m

$448

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 2/23

7:00 am-12:40 am

2 stops17h 40m

Panama City Tocumen Intl

Fri 2/27

5:50 pm-12:20 pm

2 stops18h 30m

$452

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 46 results
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Best time to book a flight from South Carolina to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama

What is the cheapest month to book a flight from South Carolina to Panama?

Currently, July is the cheapest month in which you can book a flight from South Carolina to Panama (average of $230). Flying from South Carolina to Panama in December is currently the most expensive (average of $482). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Panama?

    There are many flights that can get you from South Carolina to Panama in 8h 24m. Fly via United Airlines, American Airlines, or Delta to get the fastest option. The distance between South Carolina and Panama is about 1721 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from South Carolina to Panama that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama.

  • Can I find deals for business class flights from South Carolina to Panama?

    Yes. Cheapflights offers flight deals from South Carolina to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama?

    Currently, July is the cheapest month in which you can book a flight from South Carolina to Panama (average of $230). Flying from South Carolina to Panama in December is currently the most expensive (average of $482). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Panama

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Panama City flights
John F Kennedy Intl to San José flights
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Newark to Panama City flights
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LaGuardia to San José flights
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Hobby to San José flights
O'Hare Intl to Panama City flights
Dallas/Fort Worth to San José flights
Miami to San José flights
Miami to San Salvador flights
Fort Lauderdale to San José flights
George Bush Intcntl to San José flights
Reagan-National to San Salvador flights
Boston to San José flights
Baltimore to San Salvador flights
Ontario to San Salvador flights
Los Angeles to Panama City flights
Los Angeles to Liberia flights
Atlanta to Panama City flights
Atlanta to Guatemala City flights
Hobby to Guatemala City flights
Dulles Intl to Guatemala City flights
Reagan-National to San José flights
LaGuardia to Liberia flights
Dallas/Fort Worth to Panama City flights
Denver to Liberia flights
Orlando to Panama City flights
Atlanta to San Salvador flights
Miami to Managua flights
Baltimore to Panama City flights
Baltimore to San José flights

Top 3 airlines flying from South Carolina to Panama

Discover the top 3 airlines that operate flights from South Carolina to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$309Average$519FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$353Average$575FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$369Average$457FlexibilityNo cancel feeOn-time69%

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