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$158+ Cheap flights from South Carolina to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
oct. 15 — oct. 221
mié. 10/15
mié. 10/22
1 adult, Economy
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Cheap flight deals from South Carolina to Panama

Keep the following information in mind while searching for South Carolina to Panama flight deals. Data was last updated septiembre 15, 2025.

Round-trip from

$369
(Delta)

One-way from

$158
(Avianca Connect)
From South Carolina to Panama
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One-way flight from South Carolina to Panama
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Find flight deals from South Carolina to Panama

Cheapest flights from South Carolina to Panama
Explore the most affordable flight options available from South Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 15, 2025.

This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/296:40 amCHS - PTY
1 stop7h 16mDelta
mié. 11/263:37 pmPTY - CHS
1 stop7h 11mDelta
Deal found 9/14$369
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/296:30 amCHS - PTY
2 stops8h 33mAmerican Airlines
mié. 11/52:49 pmPTY - CHS
1 stop9h 10mAmerican Airlines
Deal found 9/14$374
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/268:03 pmCHS - PTY
1 stop17h 53mDelta
mié. 11/263:37 pmPTY - CHS
1 stop8h 20mDelta
Deal found 9/14$376
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/17:57 pmCHS - PTY
1 stop17h 46mAmerican Airlines
mar. 1/202:45 pmPTY - CHS
1 stop8h 27mAmerican Airlines
Deal found 9/14$377
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/306:30 amCHS - PTY
1 stop13h 08mUnited Airlines
jue. 11/274:41 pmPTY - CHS
1 stop23h 35mUnited Airlines
Deal found 9/14$378
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/268:03 pmCHS - PTY
1 stop17h 53mDelta
mar. 11/253:37 pmPTY - CHS
1 stop17h 54mDelta
Deal found 9/14$382
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/275:35 amCHS - PTY
1 stop8h 21mDelta
sáb. 11/223:37 pmPTY - CHS
1 stop8h 20mDelta
Deal found 9/14$389
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/297:52 amGSP - PTY
1 stop6h 04mDelta
mié. 11/53:21 pmPTY - GSP
1 stop8h 34mDelta
Deal found 9/14$391
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/296:30 amCHS - PTY
2 stops8h 33mAmerican Airlines
lun. 11/242:43 pmPTY - CHS
2 stops21h 12mAmerican Airlines
Deal found 9/14$394
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/295:52 pmGSP - PTY
2 stops21h 11mAmerican Airlines
mié. 11/52:49 pmPTY - GSP
2 stops19h 14mAmerican Airlines
Deal found 9/14$396
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/268:03 pmCHS - PTY
1 stop17h 53mDelta
dom. 11/238:05 amPTY - CHS
1 stop9h 18mDelta
Deal found 9/14$396
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/27:57 pmCHS - PTY
1 stop17h 52mAmerican Airlines
mié. 11/52:49 pmPTY - CHS
1 stop9h 10mAmerican Airlines
Deal found 9/14$398

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
Use the filters below to find and compare flights from South Carolina to Panama that are best for you.

Fly from

South Carolina

Fly to

Panama

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mié. 10/29

6:40 am-12:56 pm

1 stop7h 16m

Panama City Tocumen Intl

jue. 11/27

3:37 pm-10:48 pm

1 stop7h 11m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mié. 10/29

6:40 am-12:56 pm

1 stop7h 16m

Panama City Tocumen Intl

lun. 11/24

3:37 pm-11:57 pm

1 stop8h 20m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mar. 10/28

5:35 am-12:56 pm

1 stop8h 21m

Panama City Tocumen Intl

jue. 11/27

3:37 pm-10:48 pm

1 stop7h 11m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

lun. 10/27

6:40 am-12:56 pm

1 stop7h 16m

Panama City Tocumen Intl

jue. 11/27

3:37 pm-10:48 pm

1 stop7h 11m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mar. 10/28

5:35 am-12:56 pm

1 stop8h 21m

Panama City Tocumen Intl

mié. 11/26

3:37 pm-11:57 pm

1 stop8h 20m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mar. 10/28

5:35 am-12:56 pm

1 stop8h 21m

Panama City Tocumen Intl

lun. 11/24

3:37 pm-10:48 pm

1 stop7h 11m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mié. 10/29

6:40 am-12:56 pm

1 stop7h 16m

Panama City Tocumen Intl

mié. 11/5

3:21 pm-11:59 pm

1 stop8h 38m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mié. 10/29

6:30 am-2:03 pm

2 stops8h 33m

Panama City Tocumen Intl

mié. 11/5

2:49 pm-11:59 pm

1 stop9h 10m

$374

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

lun. 12/1

6:32 pm-1:43 pm

2 stops19h 11m

Panama City Tocumen Intl

mar. 1/20

2:45 pm-10:07 am

2 stops19h 22m

$374

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mar. 10/28

6:40 am-12:56 pm

1 stop7h 16m

Panama City Tocumen Intl

mar. 11/25

3:37 pm-9:31 am

1 stop17h 54m

$376

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 37 results
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Best time to book a flight from South Carolina to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama

What is the cheapest month to book a flight from South Carolina to Panama?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama (average of $478). Flying from South Carolina to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PA?

Find hourly flight availability from South Carolina to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Panama as you normally would.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Panama?

    There are many flights that can get you from South Carolina to Panama in 7h 16m. Fly via Delta, American Airlines, or United Airlines to get the fastest option. The distance between South Carolina and Panama is about 1645 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from South Carolina to Panama that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama.

  • Can I find deals for business class flights from South Carolina to Panama?

    Yes. Cheapflights offers flight deals from South Carolina to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama (average of $478). Flying from South Carolina to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Panama

Discover the top 3 airlines that operate flights from South Carolina to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$352Average$439FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$361Average$553FlexibilityNo cancel feeOn-time71%
DeltaCheapest$369Average$575FlexibilityNo cancel feeOn-timeN/A

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