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$158+ Cheap flights from South Carolina to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
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Cheap flight deals from South Carolina to Panama

Keep the following information in mind while searching for South Carolina to Panama flight deals. Data was last updated July 31, 2025.

Round-trip from

$374
(American Airlines)

One-way from

$158
(American Airlines)

Popular in

February

Cheapest in

September

Average price

$587
From South Carolina to Panama
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One-way flight from South Carolina to Panama
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Highest demand for flights based on searches. 5% potential increase in price ($37 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from South Carolina to Panama

Cheapest flights from South Carolina to Panama
Explore the most affordable flight options available from South Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:32 pmCHS - PTY
2 stops19h 04mAmerican Airlines
Thu 12/42:45 pmPTY - CHS
1 stop9h 32mAmerican Airlines
Deal found 7/31$374
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/45:16 pmCHS - PTY
1 stop21h 58mUnited Airlines
Mon 9/83:30 pmPTY - CHS
1 stop24h 05mUnited Airlines
Deal found 7/30$406
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/137:24 pmGSP - PTY
2 stops20h 06mAmerican Airlines
Tue 8/193:30 pmPTY - GSP
2 stops18h 22mAmerican Airlines
Deal found 7/31$408
This Avianca Connect deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/210:17 amCLT - PTY
2 stops14h 53mMultiple Airlines
Wed 10/83:20 amPTY - CLT
2 stops16h 41mMultiple Airlines
Deal found 7/31$415
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/135:34 pmGSP - PTY
1 stop26h 03mUnited Airlines
Tue 8/193:30 pmPTY - GSP
1 stop23h 16mUnited Airlines
Deal found 7/31$420
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:00 amSAV - PTY
1 stop9h 31mAmerican Airlines
Tue 9/301:45 pmPTY - SAV
1 stop9h 14mAmerican Airlines
Deal found 7/30$467
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:18 amCLT - PTY
1 stop10h 13mAmerican Airlines
Tue 9/301:45 pmPTY - CLT
1 stop16h 40mAmerican Airlines
Deal found 7/30$467
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:46 amCAE - PTY
1 stop7h 10mDelta
Mon 11/103:17 pmPTY - CAE
1 stop8h 37mDelta
Deal found 7/31$467
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:28 pmCAE - PTY
2 stops19h 32mAmerican Airlines
Fri 11/72:43 pmPTY - CAE
2 stops19h 54mAmerican Airlines
Deal found 7/31$472
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/257:45 amAGS - PTY
1 stop6h 11mDelta
Wed 10/292:21 pmPTY - AGS
1 stop8h 30mDelta
Deal found 7/30$487
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:30 amCLT - PTY
1 stop8h 25mDelta
Wed 10/12:10 pmPTY - CLT
1 stop8h 36mDelta
Deal found 7/31$487
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/276:00 amAGS - PTY
2 stops9h 30mAmerican Airlines
Wed 9/31:45 pmPTY - AGS
2 stops19h 10mAmerican Airlines
Deal found 7/30$512

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from South Carolina to Panama that are best for you.

Fly from

South Carolina

Fly to

Panama

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 12/1

6:32 pm-1:36 pm

2 stops19h 04m

Panama City Tocumen Intl

Thu 12/4

2:45 pm-12:17 am

1 stop9h 32m

$374

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

5:45 am-2:02 pm

1 stop8h 17m

Panama City Tocumen Intl

Wed 2/4

3:27 pm-11:36 pm

1 stop8h 09m

$391

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

8:34 pm-3:35 pm

2 stops19h 01m

Panama City Tocumen Intl

Wed 2/4

2:45 pm-9:59 am

2 stops19h 14m

$396

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 9/4

5:16 pm-2:14 pm

1 stop21h 58m

Panama City Tocumen Intl

Mon 9/8

3:30 pm-4:35 pm

1 stop24h 05m

$406

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 10/2

10:17 am-12:10 am

2 stops14h 53m

Panama City Tocumen Intl

Wed 10/8

3:20 am-9:01 pm

2 stops16h 41m

$415

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 8/13

5:34 pm-6:37 pm

1 stop26h 03m

Panama City Tocumen Intl

Tue 8/19

3:30 pm-3:46 pm

1 stop23h 16m

$420

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 1/16

6:30 am-8:04 pm

1 stop13h 34m

Panama City Tocumen Intl

Sun 2/1

3:27 pm-11:39 pm

1 stop8h 12m

$426

SavannahPanama City

SAV - PTY

SAVPTY

Savannah/Hilton Head

Thu 9/25

6:00 am-2:31 pm

1 stop9h 31m

Panama City Tocumen Intl

Tue 9/30

1:45 pm-11:59 pm

1 stop9h 14m

$467

ColumbiaPanama City

CAE - PTY

CAEPTY

Columbia Metropolitan

Thu 10/30

6:46 am-12:56 pm

1 stop7h 10m

Panama City Tocumen Intl

Mon 11/10

3:17 pm-11:54 pm

1 stop8h 37m

$467

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 9/25

5:18 am-2:31 pm

1 stop10h 13m

Panama City Tocumen Intl

Tue 9/30

1:45 pm-7:25 am

1 stop16h 40m

$467

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/31

Showing 1-10 of 35 results
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Best time to book a flight from South Carolina to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama

What is the cheapest month to book a flight from South Carolina to Panama?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama (average of $478). Flying from South Carolina to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PA?

Find hourly flight availability from South Carolina to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Panama as you normally would.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated July 31, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from South Carolina to Panama have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,900 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Avianca
6.7
Okay
2,388 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from South Carolina to Panama one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $158. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from South Carolina to Panama for a low price.

  • Can I find deals for flights from South Carolina to Panama that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama.

  • Can I find deals for business class flights from South Carolina to Panama?

    Yes. Cheapflights offers flight deals from South Carolina to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama (average of $478). Flying from South Carolina to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Panama

Discover the top 3 airlines that operate flights from South Carolina to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$331Average$587FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$352Average$450FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$362Average$555FlexibilityNo cancel feeOn-time71%

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