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$152+ Cheap flights from South Carolina to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/5. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Find flight deals from South Carolina to Panama

Cheapest flights from South Carolina to Panama
Explore the most affordable flight options available from South Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1310:42 pmCLT - PTY
1 stop9h 24mMultiple Airlines
Thu 11/209:33 pmPTY - CLT
1 stop11h 16mMultiple Airlines
Deal found 11/2$389
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:42 pmCLT - PTY
1 stop9h 24mMultiple Airlines
Fri 11/1410:47 amPTY - CLT
1 stop11h 10mMultiple Airlines
Deal found 11/1$398
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2610:45 pmCLT - PTY
1 stop14h 58mAmerican Airlines
Wed 12/242:53 pmPTY - CLT
1 stop9h 06mAmerican Airlines
Deal found 11/2$400
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/65:00 amGSP - PTY
1 stop8h 49mAmerican Airlines
Thu 11/132:49 pmPTY - GSP
1 stop9h 10mAmerican Airlines
Deal found 10/31$404
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/210:36 pmCLT - PTY
2 stops15h 11mAmerican Airlines
Tue 12/92:50 pmPTY - CLT
2 stops15h 39mAmerican Airlines
Deal found 11/2$404
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/195:00 amGSP - PTY
1 stop8h 49mAmerican Airlines
Wed 11/262:43 pmPTY - GSP
2 stops19h 45mAmerican Airlines
Deal found 11/2$408
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:42 pmCLT - PTY
1 stop9h 24mMultiple Airlines
Wed 11/129:33 pmPTY - CLT
1 stop10h 14mMultiple Airlines
Deal found 11/1$409
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/56:45 amGSP - PTY
1 stop12h 53mUnited Airlines
Tue 11/114:41 pmPTY - GSP
1 stop22h 58mUnited Airlines
Deal found 10/31$412
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:42 pmCLT - PTY
1 stop9h 24mMultiple Airlines
Sat 11/159:33 pmPTY - CLT
1 stop10h 14mMultiple Airlines
Deal found 11/1$416
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/114:56 pmGSP - PTY
1 stop26h 42mUnited Airlines
Tue 11/254:41 pmPTY - GSP
1 stop22h 58mUnited Airlines
Deal found 11/1$420
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1010:42 pmCLT - PTY
1 stop9h 48mMultiple Airlines
Tue 11/188:10 amPTY - CLT
2 stops11h 48mMultiple Airlines
Deal found 11/2$422
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:00 amCHS - PTY
1 stop9h 42mAmerican Airlines
Tue 12/234:55 pmPTY - CHS
1 stop7h 50mAmerican Airlines
Deal found 11/1$423

Cheap flight deals from South Carolina to Panama

Keep the following information in mind while searching for South Carolina to Panama flight deals. Data was last updated November 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$389
(Kiwi.com)

One-way from

$152
(United Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
Search Deals
From South Carolina to Panama
Search Deals
One-way flight from South Carolina to Panama
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from South Carolina to Panama that are best for you.

Fly from

South Carolina

Fly to

Panama

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:40 am-2:45 pm

1 stop8h 05m

Panama City Tocumen Intl

Wed 2/4

11:35 am-9:57 pm

1 stop10h 22m

$392

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

7:00 am-1:27 pm

1 stop6h 27m

Panama City Tocumen Intl

Wed 2/4

2:27 pm-11:57 pm

1 stop9h 30m

$392

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 1/19

5:26 pm-1:27 pm

2 stops20h 01m

Panama City Tocumen Intl

Thu 1/22

4:50 pm-11:57 pm

1 stop7h 07m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 11/19

5:00 am-1:49 pm

1 stop8h 49m

Panama City Tocumen Intl

Wed 11/26

2:43 pm-11:59 pm

1 stop9h 16m

$404

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 1/29

6:30 am-1:27 pm

1 stop6h 57m

Panama City Tocumen Intl

Mon 2/2

4:50 pm-7:31 am

2 stops14h 41m

$410

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 2/17

9:54 am-2:02 pm

1 stop28h 08m

Panama City Tocumen Intl

Thu 2/26

3:27 pm-8:42 am

1 stop17h 15m

$412

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 11/13

9:38 pm-4:55 pm

2 stops19h 17m

Panama City Tocumen Intl

Thu 11/20

5:50 pm-8:49 am

2 stops14h 59m

$413

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 1/16

5:41 pm-1:27 pm

2 stops19h 46m

Panama City Tocumen Intl

Sun 2/1

4:50 pm-11:55 pm

1 stop7h 05m

$419

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 11/15

8:30 am-7:59 pm

1 stop11h 29m

Panama City Tocumen Intl

Mon 11/24

3:37 pm-10:34 pm

1 stop6h 57m

$424

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Fri 11/14

10:07 am-7:59 pm

1 stop9h 52m

Panama City Tocumen Intl

Mon 11/24

3:37 pm-10:34 pm

1 stop6h 57m

$424

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Showing 1-10 of 44 results
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Best time to book a flight from South Carolina to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama

What is the cheapest month to book a flight from South Carolina to Panama?

Currently, July is the cheapest month in which you can book a flight from South Carolina to Panama (average of $230). Flying from South Carolina to Panama in May is currently the most expensive (average of $419). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PA?

Find hourly flight availability from South Carolina to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 3, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 26% on flights from South Carolina to Panama by exploring options for tickets in the afternoon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Panama?

    There are many flights that can get you from South Carolina to Panama in 6h 27m. Fly via United Airlines, American Airlines, or Delta to get the fastest option. The distance between South Carolina and Panama is about 1792 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to Panama one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $152. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from South Carolina to Panama for a low price.

  • Can I find deals for flights from South Carolina to Panama that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama.

  • Can I find deals for business class flights from South Carolina to Panama?

    Yes. Cheapflights offers flight deals from South Carolina to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama?

    Currently, July is the cheapest month in which you can book a flight from South Carolina to Panama (average of $230). Flying from South Carolina to Panama in May is currently the most expensive (average of $419). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Panama

Discover the top 3 airlines that operate flights from South Carolina to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$369Average$531FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$383Average$448FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$383Average$561FlexibilityNo cancel feeOn-time71%

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