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$152+ Cheap flights from South Carolina to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/2. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from South Carolina to Panama

Cheapest flights from South Carolina to Panama
Explore the most affordable flight options available from South Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:15 amCHS - PTY
1 stop11h 45mDelta
Fri 12/268:00 amPTY - CHS
1 stop7h 08mDelta
Deal found 12/17$553
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:22 amCLT - PTY
1 stop13h 16mUnited Airlines
Thu 12/2511:35 amPTY - CLT
1 stop10h 07mUnited Airlines
Deal found 12/17$586
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:27 pmCHS - PTY
2 stops19h 26mAmerican Airlines
Fri 12/264:55 pmPTY - CHS
1 stop15h 52mAmerican Airlines
Deal found 12/17$588
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:30 amCHS - PTY
1 stop8h 23mAmerican Airlines
Sun 12/282:53 pmPTY - CHS
1 stop9h 52mAmerican Airlines
Deal found 12/15$609
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:00 amMYR - PTY
1 stop7h 57mDelta
Tue 12/308:00 amPTY - MYR
1 stop12h 30mDelta
Deal found 12/17$640
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:44 pmGSP - PTY
1 stop25h 54mUnited Airlines
Tue 1/64:41 pmPTY - GSP
1 stop29h 16mUnited Airlines
Deal found 12/17$647
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:16 pmCAE - PTY
2 stops19h 37mAmerican Airlines
Thu 12/252:53 pmPTY - CAE
2 stops17h 46mAmerican Airlines
Deal found 12/16$660
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:30 amCHS - PTY
1 stop13h 08mUnited Airlines
Tue 1/64:41 pmPTY - CHS
1 stop23h 36mUnited Airlines
Deal found 12/16$669
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:22 amCLT - PTY
1 stop13h 16mUnited Airlines
Tue 1/610:00 amPTY - CLT
1 stop11h 16mUnited Airlines
Deal found 12/17$678
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1911:38 amCLT - PTY
1 stop8h 21mDelta
Tue 12/238:00 amPTY - CLT
1 stop10h 13mDelta
Deal found 12/16$687
This American Airlines deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:20 pmGSP - PTY
2 stops21h 34mAmerican Airlines
Tue 1/64:31 pmPTY - GSP
2 stops17h 59mAmerican Airlines
Deal found 12/18$710
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/169:45 pmCLT - PTY
1 stop16h 02mAmerican Airlines
Mon 12/222:53 pmPTY - CLT
1 stop17h 18mAmerican Airlines
Deal found 12/15$713

Find flight deals from South Carolina to Panama

Keep the following information in mind while searching for South Carolina to Panama flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$374
(American Airlines)

One-way from

$152
(United Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
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From South Carolina to Panama
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One-way flight from South Carolina to Panama
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Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from South Carolina to Panama that are best for you.

Fly from

South Carolina

Fly to

Panama

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 1/30

6:10 am-3:38 pm

2 stops9h 28m

Panama City Tocumen Intl

Fri 2/6

2:27 pm-9:48 am

2 stops19h 21m

$374

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 1/26

11:00 am-8:02 pm

1 stop9h 02m

Panama City Tocumen Intl

Thu 1/29

11:35 am-4:17 pm

1 stop28h 42m

$378

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:49 am-5:07 pm

1 stop10h 18m

Panama City Tocumen Intl

Wed 2/4

9:55 am-9:57 pm

1 stop12h 02m

$392

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 1/19

6:49 am-2:45 pm

1 stop7h 56m

Panama City Tocumen Intl

Thu 1/22

11:35 am-9:57 pm

1 stop10h 22m

$392

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 3/14

7:02 pm-2:22 pm

2 stops20h 20m

Panama City Tocumen Intl

Tue 3/17

3:13 pm-11:59 pm

1 stop7h 46m

$394

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

7:00 pm-3:38 pm

2 stops20h 38m

Panama City Tocumen Intl

Wed 2/4

2:27 pm-10:30 am

2 stops20h 03m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 1/5

6:26 pm-1:27 pm

2 stops19h 01m

Panama City Tocumen Intl

Fri 1/16

2:27 pm-10:23 am

2 stops19h 56m

$402

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Wed 1/7

9:27 am-3:31 pm

1 stop6h 04m

Panama City Tocumen Intl

Fri 1/23

4:50 pm-11:58 pm

1 stop7h 08m

$402

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Fri 4/10

6:32 pm-12:15 pm

2 stops18h 43m

Panama City Tocumen Intl

Tue 4/14

1:55 pm-11:03 pm

1 stop8h 08m

$414

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 3/14

6:37 pm-12:40 pm

2 stops19h 03m

Panama City Tocumen Intl

Sat 3/21

1:44 pm-10:17 am

2 stops19h 33m

$414

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama

What is the cheapest month to book a flight from South Carolina to Panama?

Currently, July is the cheapest month in which you can book a flight from South Carolina to Panama (average of $230). Flying from South Carolina to Panama in May is currently the most expensive (average of $419). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PA?

Find hourly flight availability from South Carolina to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 26% on flights from South Carolina to Panama by exploring options for tickets in the afternoon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Panama?

    There are many flights that can get you from South Carolina to Panama in 8h 15m. Fly via American Airlines, United Airlines, or Delta to get the fastest option. The distance between South Carolina and Panama is about 1721 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from South Carolina to Panama that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama.

  • Can I find deals for business class flights from South Carolina to Panama?

    Yes. Cheapflights offers flight deals from South Carolina to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama?

    Currently, July is the cheapest month in which you can book a flight from South Carolina to Panama (average of $230). Flying from South Carolina to Panama in May is currently the most expensive (average of $419). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Panama

Discover the top 3 airlines that operate flights from South Carolina to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$349Average$521FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$353Average$559FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$369Average$446FlexibilityNo cancel feeOn-time69%

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