What are the cheapest airlines to fly from Spartanburg to Panama City one-way?

The cheapest airlines for a one-way flight from Spartanburg to Panama City are American Airlines ($221), United Airlines ($237), and Delta ($261).

What is the cheapest day to fly from Spartanburg to Panama City?

Travelers seeking maximum savings on their Spartanburg to Panama City flight should consider departing on Friday evenings when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from Spartanburg to Panama City?

Consider American Airlines, Delta or United Airlines when booking your flight. These represent the most popular airlines when flying from Spartanburg to Panama City.

How far in advance should I book a flight from Spartanburg to Panama City?

To save up to 43% on this flight, we recommend booking at least 53 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from Spartanburg to Panama City from $513 1-2 weeks out and tickets from $706 for flights departing within the next 72 hours.

What is the cheapest month to fly from Spartanburg to Panama City?

September is one of the best times of the year to fly to Panama City from Spartanburg. Prices for September average $575 per person but you can even find prices for as low as $467. The most expensive prices can be found in the month of December. Opting for a September flight can save you 54% on your journey compared to booking in December

What airport do you fly into for flights to Panama City from Spartanburg?

Panama City Tocumen Intl (PTY) is the airport you will fly into if you book a flight from Spartanburg to Panama City. You should not have trouble finding flights to Tocumen Intl from Spartanburg; the airport handles an average of 0 inbound flights from Spartanburg per day. You should also have plenty of airline options to choose from since 3 airlines have flights to the Panama City airport from Spartanburg. It is only a 11.4 mi journey from Tocumen Intl (PTY) to Panama City’s city center.

Can I find deals for flights from Spartanburg to Panama City that include hotel bookings?

Yes. In addition to deals on Spartanburg to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Spartanburg to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Panama City.

Can I find deals for business class flights from Spartanburg to Panama City?

Yes. Cheapflights offers flight deals from Spartanburg to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$221+ Flights from Spartanburg to Panama City

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

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Cheapflights Tip: The best prices from Spartanburg to Panama City Tocumen Intl are usually found in September or May, booked 52 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Cheap flight deals from Spartanburg to Panama City

Round-trip from	$460 (Kiwi.com)
One-way from	$221 (American Airlines)
Popular in	December
Cheapest in	September
Average price	$569

From Spartanburg to Panama City Tocumen Intl

Search Deals

One-way flight from Spartanburg to Panama City Tocumen Intl

Search Deals

Highest demand for flights based on searches. 16% potential increase in price ($111 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($29 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Find flight deals from Spartanburg to Panama City

Cheapest flights from Spartanburg to Panama City
Explore the most affordable flight options available from Spartanburg to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 23, 2025.

Sun 8/179:12 amCLT - PTY

1 stop11h 17mMultiple Airlines

Sun 8/249:33 pmPTY - CLT

1 stop14h 05mMultiple Airlines

Deal found 6/23

$460

Thu 8/2810:25 pmCLT - PTY

1 stop17h 05mAmerican Airlines

Tue 9/23:30 pmPTY - CLT

1 stop16h 43mAmerican Airlines

Deal found 6/21

$467

Sat 8/305:35 amCLT - PTY

1 stop8h 15mDelta

Thu 9/42:05 pmPTY - CLT

1 stop8h 46mDelta

Deal found 6/23

$487

Thu 10/237:00 amCLT - PTY

1 stop8h 14mUnited Airlines

Sun 10/263:41 pmPTY - CLT

1 stop29h 18mUnited Airlines

Deal found 6/23

$497

Best flights from Spartanburg to Panama City
Discover carefully curated flight deals from Spartanburg to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 23, 2025.

Sun 8/179:12 amCLT - PTY

1 stop11h 17mMultiple Airlines

Sun 8/249:33 pmPTY - CLT

1 stop14h 05mMultiple Airlines

Deal found 6/23

$460

Thu 8/2810:25 pmCLT - PTY

1 stop17h 05mAmerican Airlines

Tue 9/23:30 pmPTY - CLT

1 stop16h 43mAmerican Airlines

Deal found 6/21

$467

Sat 8/305:35 amCLT - PTY

1 stop8h 15mDelta

Thu 9/42:05 pmPTY - CLT

1 stop8h 46mDelta

Deal found 6/23

$487

Thu 7/247:00 amCLT - PTY

1 stop8h 14mUnited Airlines

Mon 7/283:30 pmPTY - CLT

1 stop18h 30mUnited Airlines

Deal found 6/23

$507

Tue 9/910:25 amCLT - PTY

2 stops14h 45mAvianca

Mon 9/153:25 amPTY - CLT

2 stops14h 28mAvianca

Deal found 6/22

$1,400

Mon 7/286:00 amCLT - PTY

1 stop8h 31mCopa Airlines

Thu 7/3110:29 pmPTY - CLT

1 stop10h 19mCopa Airlines

Deal found 6/21

$1,616

Last-minute flights from Spartanburg to Panama City
Discover last-minute flight deals from Spartanburg to Panama City. Data last updated June 23, 2025 and is based on user searches.

Sat 6/286:15 amCLT - PTY

2 stops9h 10mAmerican Airlines

Mon 6/303:20 pmPTY - CLT

2 stops14h 15mAmerican Airlines

Deal found 6/21

$652

Wed 7/27:00 amCLT - PTY

1 stop8h 14mUnited Airlines

Wed 7/97:55 amPTY - CLT

1 stop13h 02mUnited Airlines

Deal found 6/21

$577

Wed 7/211:28 amCLT - PTY

2 stops14h 17mMultiple Airlines

Tue 7/83:20 amPTY - CLT

2 stops13h 39mMultiple Airlines

Deal found 6/21

$604

Mon 7/79:32 pmCLT - PTY

2 stops16h 03mMultiple Airlines

Thu 7/103:20 amPTY - CLT

2 stops13h 39mMultiple Airlines

Deal found 6/23

$497

Thu 7/247:00 amCLT - PTY

1 stop8h 14mUnited Airlines

Mon 7/283:30 pmPTY - CLT

1 stop18h 30mUnited Airlines

Deal found 6/23

$507

Mon 7/286:00 amCLT - PTY

1 stop8h 31mCopa Airlines

Thu 7/3110:29 pmPTY - CLT

1 stop10h 19mCopa Airlines

Deal found 6/21

$1,616

Thu 7/319:22 pmCLT - PTY

1 stop16h 32mAmerican Airlines

Sun 8/31:55 pmPTY - CLT

1 stop16h 31mAmerican Airlines

Deal found 6/21

$527

Thu 7/3110:29 amCLT - PTY

2 stops14h 41mAvianca

Sun 8/38:10 pmPTY - CLT

2 stops12h 38mAvianca

Deal found 6/23

$1,654

One-way flights from Spartanburg to Panama City
Search for one-way flight options from Spartanburg to Panama City. Find affordable one-way fares based on user searches. Data last updated June 23, 2025.

Thu 7/3110:29 pmCLT - PTY

1 stop15h 25mAmerican Airlines

Deal found 6/22

$221

Sat 7/198:48 amCLT - PTY

2 stops30h 52mMultiple Airlines

Deal found 6/22

$236

Sun 7/205:00 pmCLT - PTY

1 stop22h 14mUnited Airlines

Deal found 6/22

$237

Sat 7/199:30 amCLT - PTY

1 stop10h 33mDelta

Deal found 6/22

$261

Cheapflights Fare Finder

Use the filters below to find and compare flights from Spartanburg to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sun 8/17

9:12 am-7:29 pm

1 stop11h 17m

Panama City Tocumen Intl

Sun 8/24

9:33 pm-12:38 pm

1 stop14h 05m

$460

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 8/28

10:25 pm-2:30 pm

1 stop17h 05m

Panama City Tocumen Intl

Tue 9/2

3:30 pm-9:13 am

1 stop16h 43m

$467

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 8/30

5:35 am-12:50 pm

1 stop8h 15m

Panama City Tocumen Intl

Thu 9/4

2:05 pm-11:51 pm

1 stop8h 46m

$487

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 7/24

7:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Mon 7/28

3:30 pm-11:00 am

1 stop18h 30m

$507

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 9/9

10:25 am-12:10 am

2 stops14h 45m

Panama City Tocumen Intl

Mon 9/15

3:25 am-6:53 pm

2 stops14h 28m

$1,400

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 7/28

6:00 am-1:31 pm

1 stop8h 31m

Panama City Tocumen Intl

Thu 7/31

10:29 pm-9:48 am

1 stop10h 19m

$1,616

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 7/31

10:29 pm-12:54 pm

1 stop15h 25m

$221

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 7/19

8:48 am-2:40 pm

2 stops30h 52m

$236

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sun 7/20

5:00 pm-2:14 pm

1 stop22h 14m

$237

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 7/19

9:30 am-7:03 pm

1 stop10h 33m

$261

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/22

Best time to book a flight from Spartanburg to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Spartanburg with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Panama City

How far ahead should I book a flight from Spartanburg to Panama City?

The best time to book flights from Spartanburg to Panama City is 52 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Spartanburg to Panama City?

Currently, October is the cheapest month in which you can book a flight from Spartanburg to Panama City (average of $478). Flying from Spartanburg to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to PTY?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Spartanburg to Panama City as you normally would.

Rainfall in Panama City by month

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Read reviews from past customers who have flown Delta, Copa Airlines and United Airlines from Spartanburg to Panama City. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,965 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,965 reviews

Delta

8.0

Very good

7,965 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Copa Airlines

7.5

Good

1,460 reviews

Delta

8.0

Very good

7,965 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,831 reviews

Delta

8.0

Very good

7,965 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,965 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Avianca

6.7

Okay

2,352 reviews

Delta

8.0

Very good

7,965 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What airport do you fly into for flights to Panama City from Spartanburg?
Panama City Tocumen Intl (PTY) is the airport you will fly into if you book a flight from Spartanburg to Panama City. You should not have trouble finding flights to Tocumen Intl from Spartanburg; the airport handles an average of 0 inbound flights from Spartanburg per day. You should also have plenty of airline options to choose from since 3 airlines have flights to the Panama City airport from Spartanburg. It is only a 11.4 mi journey from Tocumen Intl (PTY) to Panama City’s city center.
What are the cheapest airlines to fly from Spartanburg to Panama City one-way?
The cheapest airlines for a one-way flight from Spartanburg to Panama City are American Airlines ($221), United Airlines ($237), and Delta ($261).
Can I find deals for flights from Spartanburg to Panama City that include hotel bookings?
Yes. In addition to deals on Spartanburg to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Spartanburg to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Panama City.
Can I find deals for business class flights from Spartanburg to Panama City?
Yes. Cheapflights offers flight deals from Spartanburg to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Spartanburg to Panama City?
Currently, October is the cheapest month in which you can book a flight from Spartanburg to Panama City (average of $478). Flying from Spartanburg to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Spartanburg to Panama City

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$285	Average$461	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$341	Average$562	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$352	Average$575	FlexibilityNo cancel fee	On-time71%

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$221+ Cheap flights from Spartanburg, SC to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/31. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Spartanburg to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Spartanburg to Panama City Tocumen Intl are usually found in September or May, booked 52 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Cheap flight deals from Spartanburg to Panama City

Keep the following information in mind while searching for Spartanburg to Panama City flight deals. Data was last updated June 23, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Spartanburg to Panama City

Cheapest flights from Spartanburg to Panama CityExplore the most affordable flight options available from Spartanburg to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 23, 2025.

Explore the most affordable flight options available from Spartanburg to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 23, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Spartanburg to Panama City that are best for you.

Best time to book a flight from Spartanburg to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Spartanburg with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Panama City

How far ahead should I book a flight from Spartanburg to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Spartanburg to Panama City. Price data was last updated on June 20, 2025.

What is the cheapest month to book a flight from Spartanburg to Panama City?

What is the cheapest time of day to fly from SB1 to PTY?

Find hourly flight availability from Spartanburg to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 23, 2025.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

Reviews of airlines servicing Panama City

Read reviews from past customers who have flown Delta, Copa Airlines and United Airlines from Spartanburg to Panama City. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Panama City from Spartanburg?

What are the cheapest airlines to fly from Spartanburg to Panama City one-way?

Can I find deals for flights from Spartanburg to Panama City that include hotel bookings?

How can I find direct flights from Spartanburg to Panama City?

Can I find deals for business class flights from Spartanburg to Panama City?

What is the cheapest month to book a flight from Spartanburg to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Spartanburg to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Spartanburg to Panama City

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Travel Smart

Cheapest flights from Spartanburg to Panama City
Explore the most affordable flight options available from Spartanburg to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 23, 2025.