HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$221+ Cheap flights from Spartanburg, SC to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — PTY
Oct 18 — Oct 251
Sat 10/18
Sat 10/25
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Spartanburg to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Spartanburg to Panama City Tocumen Intl are usually found in October or May, booked 21 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Cheap flight deals from Spartanburg to Panama City

Keep the following information in mind while searching for Spartanburg to Panama City flight deals. Data was last updated September 18, 2025.

Round-trip from

$388
(Avianca Connect)

One-way from

$221
(Delta)

Popular in

December

Cheapest in

October

Average price

$512
From Spartanburg to Panama City Tocumen Intl
Search Deals
One-way flight from Spartanburg to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($124 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($34 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Spartanburg to Panama City

Cheapest flights from Spartanburg to Panama City
Explore the most affordable flight options available from Spartanburg to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2025.

This Avianca Connect deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/225:45 amCLT - PTY
2 stops20h 00mMultiple Airlines
Sun 10/262:55 amPTY - CLT
2 stops19h 33mMultiple Airlines
Deal found 9/17$388
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/205:30 amCLT - PTY
1 stop8h 26mDelta
Wed 10/222:21 pmPTY - CLT
1 stop8h 29mDelta
Deal found 9/16$395
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2010:25 pmCLT - PTY
1 stop16h 38mAmerican Airlines
Wed 10/223:15 pmPTY - CLT
2 stops14h 11mAmerican Airlines
Deal found 9/16$400
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/410:45 pmCLT - PTY
1 stop15h 02mAmerican Airlines
Fri 12/124:37 pmPTY - CLT
1 stop16h 38mAmerican Airlines
Deal found 9/16$403
This Avianca Connect deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/410:46 amCLT - PTY
2 stops14h 24mMultiple Airlines
Tue 10/73:20 amPTY - CLT
2 stops19h 08mMultiple Airlines
Deal found 9/17$409
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:15 amCLT - PTY
1 stop7h 41mDelta
Tue 10/282:21 pmPTY - CLT
1 stop8h 29mDelta
Deal found 9/16$415
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/257:00 amCLT - PTY
1 stop8h 14mUnited Airlines
Mon 11/38:55 amPTY - CLT
1 stop12h 41mUnited Airlines
Deal found 9/15$419
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2210:37 pmCLT - PTY
2 stops16h 26mAmerican Airlines
Mon 10/273:15 pmPTY - CLT
2 stops15h 33mAmerican Airlines
Deal found 9/17$420
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/38:43 pmCLT - PTY
1 stop17h 06mAmerican Airlines
Sat 11/82:49 pmPTY - CLT
1 stop7h 51mAmerican Airlines
Deal found 9/17$423
This Avianca Connect deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2510:19 amCLT - PTY
2 stops11h 51mMultiple Airlines
Sun 11/22:55 pmPTY - CLT
2 stops21h 44mMultiple Airlines
Deal found 9/15$424

Cheapflights Fare Finder

 
Customize your flight search to find flights from Spartanburg to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 18, 2025.
Use the filters below to find and compare flights from Spartanburg to Panama City that are best for you.

Fly from

Spartanburg

Fly to

Panama City

Route

Depart

Return

Price

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 10/20

5:30 am-12:56 pm

1 stop8h 26m

Panama City Tocumen Intl

Wed 10/22

2:21 pm-11:50 pm

1 stop8h 29m

$395

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 10/22

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Mon 10/27

7:55 am-9:59 pm

1 stop13h 04m

$395

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Fri 10/24

5:45 am-9:10 pm

2 stops16h 25m

Panama City Tocumen Intl

Sun 10/26

2:55 am-8:59 pm

2 stops17h 04m

$409

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 10/25

6:15 am-12:56 pm

1 stop7h 41m

Panama City Tocumen Intl

Tue 10/28

2:21 pm-11:50 pm

1 stop8h 29m

$415

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 10/25

7:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Mon 11/3

8:55 am-9:36 pm

1 stop12h 41m

$419

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 10/20

6:00 am-2:03 pm

2 stops9h 03m

Panama City Tocumen Intl

Thu 10/23

3:15 pm-7:50 am

2 stops15h 35m

$420

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 10/25

7:07 am-2:03 pm

1 stop7h 56m

Panama City Tocumen Intl

Tue 10/28

3:15 pm-7:50 am

2 stops15h 35m

$420

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 10/23

10:25 pm-2:03 pm

1 stop16h 38m

Panama City Tocumen Intl

Sun 10/26

3:15 pm-8:25 am

1 stop16h 10m

$420

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 11/15

6:45 am-7:38 pm

1 stop12h 53m

Panama City Tocumen Intl

Mon 11/17

8:55 am-9:36 pm

1 stop12h 41m

$423

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 11/25

5:30 am-2:12 pm

1 stop8h 42m

$221

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 13 results
1
2

Best time to book a flight from Spartanburg to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Panama City

How far ahead should I book a flight from Spartanburg to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Spartanburg to Panama City. Price data was last updated on September 12, 2025.

The best time to book flights from Spartanburg to Panama City is 21 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Spartanburg to Panama City?

Currently, October is the cheapest month in which you can book a flight from Spartanburg to Panama City (average of $478). Flying from Spartanburg to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to PTY?

Find hourly flight availability from Spartanburg to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 18, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Spartanburg to Panama City as you normally would.

How much does it cost to fly round-trip from Spartanburg to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 18, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Spartanburg to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Spartanburg?

    Panama City Tocumen Intl (PTY) is the airport you will fly into if you book a flight from Spartanburg to Panama City. You should not have trouble finding flights to Tocumen Intl from Spartanburg; the airport handles an average of 0 inbound flights from Spartanburg per day. You should also have plenty of airline options to choose from since 3 airlines have flights to the Panama City airport from Spartanburg. It is only a 11.4 mi journey from Tocumen Intl (PTY) to Panama City’s city center.

  • How long is the flight from Spartanburg to Panama City?

    Airlines like Delta and United Airlines fly from Spartanburg to Panama City in about 8h 26m. The time it takes to get you to your destination can typically vary by up to 4h 11m. There are 1808 mi between Spartanburg and Panama City. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Spartanburg to Panama City one-way?

    The cheapest airlines for a one-way flight from Spartanburg to Panama City are Delta ($221), American Airlines ($221), and United Airlines ($241).

  • Can I find deals for flights from Spartanburg to Panama City that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Panama City.

  • Can I find deals for business class flights from Spartanburg to Panama City?

    Yes. Cheapflights offers flight deals from Spartanburg to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Spartanburg to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Spartanburg to Panama City (average of $478). Flying from Spartanburg to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Spartanburg to Panama City

Discover the top 3 airlines that operate flights from Spartanburg to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$352Average$464FlexibilityNo cancel feeOn-time69%
DeltaCheapest$371Average$584FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$376Average$575FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.