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Panama City

$131+ Cheap flights from Mexico City (MEX) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/14. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
May 1 — May 81
Fri 5/1
Fri 5/8
1 adult, Economy
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Find cheap flights from Mexico City to Panama City with Cheapflights

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Cheapflights Tip: The best prices from Mexico City Benito Juarez to Panama City Tocumen Intl are usually found in August or July, booked 72 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from Mexico City to Panama City

Cheapest flights from Mexico City to Panama City
Explore the most affordable flight options available from Mexico City to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 1, 2026.

This KAYAK deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/231:10 pm
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Thu 5/79:29 pm
PTY
-
MEX
Nonstop3h 46m
Copa Airlines
Deal found 3/30$275
This Copa Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1412:25 am
MEX
-
PTY
Nonstop3h 36m
Copa Airlines
Mon 4/279:26 pm
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Deal found 3/30$291
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:10 am
MEX
-
PTY
Nonstop3h 36m
Multiple Airlines
Tue 5/55:30 am
PTY
-
MEX
1 stop6h 25m
Multiple Airlines
Deal found 3/29$311
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:50 am
MEX
-
PTY
Nonstop3h 36m
Copa Airlines
Sat 5/3011:45 am
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Deal found 3/28$318
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/72:10 am
MEX
-
PTY
Nonstop3h 36m
Multiple Airlines
Fri 5/153:10 pm
PTY
-
MEX
1 stop8h 50m
Multiple Airlines
Deal found 3/30$322
This FlightHub deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/44:55 am
MEX
-
PTY
1 stop11h 05m
Avianca
Thu 5/143:10 pm
PTY
-
MEX
1 stop8h 50m
Avianca
Deal found 3/30$331
This Copa Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/101:10 pm
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Mon 4/209:26 pm
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Deal found 3/28$332
This FlightHub deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/194:55 am
MEX
-
PTY
1 stop11h 05m
Avianca
Wed 4/293:10 pm
PTY
-
MEX
1 stop8h 50m
Avianca
Deal found 3/29$334
This FlightHub deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1512:40 am
MEX
-
PTY
1 stop12h 35m
Avianca
Sun 4/265:30 am
PTY
-
MEX
1 stop6h 25m
Avianca
Deal found 3/30$335
This Copa Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/152:10 am
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Sun 4/264:10 pm
PTY
-
MEX
Nonstop3h 55m
Copa Airlines
Deal found 3/30$345
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/194:55 am
MEX
-
PTY
1 stop8h 20m
Multiple Airlines
Tue 4/287:10 pm
PTY
-
MEX
Nonstop3h 55m
Multiple Airlines
Deal found 3/29$348

Find flight deals from Mexico City to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 1, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$275
(KAYAK)

One-way from

$131
(Copa Airlines)

Popular in

April

Cheapest in

August

Average price

$423

Good round-trip deal

$377 or less

Good one-way deal

$189 or less
Provider with most accurate pricing for Mexico City Benito Juarez-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Mexico City Benito Juarez-Panama City Tocumen Intl flights.
Search Deals
From Mexico City Benito Juarez to Panama City Tocumen Intl
Search Deals
One-way flight from Mexico City Benito Juarez to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($35 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals
Price to beat on a round-trip flight from Mexico City Benito Juarez to Panama City Tocumen Intl.
Search Deals
Price to beat on a one-way flight from Mexico City Benito Juarez to Panama City Tocumen Intl.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2026.
Use the filters below to find and compare flights from Mexico City to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 4/18

2:10 am-6:50 am

Nonstop3h 40m

Panama City Tocumen Intl

Wed 4/29

4:10 pm-7:05 pm

Nonstop3h 55m

$291

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 4/23

1:10 pm-5:53 pm

Nonstop3h 43m

Panama City Tocumen Intl

Thu 4/30

10:11 pm-1:00 am

Nonstop3h 49m

$291

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 4/15

2:10 am-6:50 am

Nonstop3h 40m

Panama City Tocumen Intl

Sun 4/26

4:10 pm-7:05 pm

Nonstop3h 55m

$345

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 6/29

9:50 am-2:36 pm

Nonstop3h 46m

Panama City Tocumen Intl

Mon 7/6

9:25 am-12:10 pm

Nonstop3h 45m

$399

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 6/26

1:20 am-6:03 am

Nonstop3h 43m

Panama City Tocumen Intl

Sun 7/5

11:45 am-2:30 pm

Nonstop3h 45m

$399
Quickest round-trip

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 4/21

1:20 am-5:56 am

Nonstop3h 36m

Panama City Tocumen Intl

Sun 5/10

11:45 am-2:30 pm

Nonstop3h 45m

$399

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 4/20

3:30 pm-8:10 pm

Nonstop3h 40m

Panama City Tocumen Intl

Mon 4/27

9:26 pm-12:15 am

Nonstop3h 49m

$399

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 6/25

1:20 am-6:03 am

Nonstop3h 43m

Panama City Tocumen Intl

Sat 7/4

9:25 am-12:10 pm

Nonstop3h 45m

$399

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 5/4

9:50 am-2:30 pm

Nonstop3h 40m

Panama City Tocumen Intl

Thu 5/14

11:45 am-2:30 pm

Nonstop3h 45m

$399
Cheapest one-way
Quickest one-way

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 5/26

12:25 am-5:01 am

Nonstop3h 36m

$131

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/28

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

Compare providers for flights from Mexico City to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Mexico City to Panama City in April.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Mexico City-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Mexico City-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Mexico City-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Mexico City-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Mexico City-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Mexico City to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Panama City

How far ahead should I book a flight from Mexico City to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Panama City. Price data was last updated on March 13, 2026.

To ensure you get the cheapest price possible for a flight from Mexico City to Panama City, you should look to book at least 72 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Mexico City to Panama City?

Currently, September is the cheapest month in which you can book a flight from Mexico City to Panama City (average of $175). Flying from Mexico City to Panama City in May is currently the most expensive (average of $292). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PTY?

Find hourly flight availability from Mexico City to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 1, 2026.

One of the essential ways to save on airfare from Mexico City to Panama City is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 18% on airfare.

What is the cheapest day to fly from Mexico City to Panama City?

Use this chart to determine the cheapest time to fly round-trip from Mexico City to Panama City. Price data was last updated on March 28, 2026.

Travelers seeking maximum savings on their Mexico City to Panama City flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Mexico City to Panama City?

The best insider tips for Mexico City to Panama City flights

AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Mexico City to Panama City trip
Our travel experts
Brandon Schultz

Brandon Schultz

Expert on MEX

Brandon Schultz is an award-winning food and travel writer based in New York City. His work has appeared in Forbes, AAA, Thrillist, Travel + Leisure, and The Daily Meal, among many others, and he is the author of 6 books, including 3 cookbooks.

Read more
Taryn White

Taryn White

Expert on PTY

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Read more

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated April 1, 2026.
Peruse reviews from past customers who have flown with Copa Airlines,Aeromexico, andAvianca from Mexico City to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,578 reviews

Food

6.8

Boarding

7.8

Overall

7.5

Entertainment

6.8

Crew

8.1

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Copa Airlines
7.5
Good
1,578 reviews
Copa Airlines
7.5
Good
1,578 reviews

Food

6.8

Boarding

7.8

Overall

7.5

Entertainment

6.8

Crew

8.1

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Aeromexico
7.4
Good
1,554 reviews
Copa Airlines
7.5
Good
1,578 reviews

Food

6.8

Boarding

7.8

Overall

7.5

Entertainment

6.8

Crew

8.1

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Avianca
6.5
Okay
2,505 reviews
Copa Airlines
7.5
Good
1,578 reviews

Food

6.8

Boarding

7.8

Overall

7.5

Entertainment

6.8

Crew

8.1

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Mexico City to Panama City?

    Panama City Tocumen Intl is the airport most travelers will use when flying to Panama City from Mexico City Benito Juarez. Booking flights from Benito Juarez (MEX) to Tocumen Intl (PTY) should be relatively easy as there are 2 daily flights to Panama City from 3 different airlines. 3h 36m is how long a flight from Mexico City to Panama City Tocumen Intl will take if you book a nonstop flight.

  • How popular is this Mexico City to Panama City flight route?

    Within the past month, 16 users have taken a look at flights from Mexico City Benito Juarez to Panama City Tocumen Intl.

  • How long is the flight from Mexico City to Panama City?

    There are many flights that can get you from Mexico City to Panama City in 3h 40m. Fly via Copa Airlines to get the fastest option. The distance between Mexico City and Panama City is about 1497 mi. Most flights are nonstop.

  • What are the cheapest airlines flying from Mexico City to Panama City round-trip?

    Our cheapest airline available from Mexico City to Panama City is Aeromexico. Our recent data shows that you can find tickets from as low as $225 on this airline. Additional options worth looking into are Copa Airlines and Avianca, starting at $246 and $337 round-trip. You may be able to fly from Mexico City to Panama City for 40% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Mexico City to Panama City one-way?

    For one-way options, check prices for Avianca. According to our data, you can fly for as low as $143. Users have also found prices from $168 and $334 on Aeromexico and Copa Airlines, respectively.

  • What are the most reliable airlines from Mexico City to Panama City?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mexico City to Panama City on time: Copa Airlines (91%), Emirates (89%), Aeromexico (89%).

  • What are the cheapest flights from Mexico City to Panama City?

    The cheapest flight price from Mexico City to Panama City is $160. On average you can expect to pay $423. The most popular route, (Mexico City Benito Juarez - Panama City Tocumen Intl), can usually be booked for $270.

  • Can I find deals for flights from Mexico City to Panama City that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama City.

  • Can I find deals for business class flights from Mexico City to Panama City?

    Yes. Cheapflights offers flight deals from Mexico City to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama City?

    Currently, September is the cheapest month in which you can book a flight from Mexico City to Panama City (average of $175). Flying from Mexico City to Panama City in May is currently the most expensive (average of $292). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Mexico City to Panama City

Discover the top 3 airlines that operate flights from Mexico City to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2026.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$225Average$363FlexibilityNo cancel feeOn-timeN/A
Copa AirlinesCheapest$246Average$419FlexibilityNo cancel feeOn-time70%
AviancaCheapest$337Average$409FlexibilityNo cancel feeOn-time71%

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