Security lines at MEX are efficient, usually under 20 minutes, but arrive early for US-bound flights due to additional checks.
$156+ Cheap flights from Mexico City (MEX) to Panama City (PTY)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/16. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
Jan 29 — Feb 51
1 adult, Economy
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Find cheap flights from Mexico City to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mexico City Benito Juarez to Panama City Tocumen Intl are usually found in July or August, booked 72 days in advance, depart on a Wednesday or Thursday and return on a Tuesday
Cheap flight deals from Mexico City to Panama City
Cheapest flights from Mexico City to Panama CityExplore the most affordable flight options available from Mexico City to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 30, 2025.
Explore the most affordable flight options available from Mexico City to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 30, 2025.
This Priceline deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:50 pmMEX - PTY
1 stop16h 40mAvianca
Sat 1/107:50 pmPTY - MEX
1 stop16h 30mAvianca
Deal found 12/29![Avianca logo]()
$465
This Kiwi.com deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/303:30 pmMEX - PTY
Nonstop3h 45mMultiple Airlines
Sun 1/119:45 amPTY - MEX
2 stops16h 30mMultiple Airlines
Deal found 12/29![Multiple Airlines logo]()
$520
This Copa Airlines deal was found by Cheapflights users on 12/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:30 pmMEX - PTY
Nonstop3h 45mCopa Airlines
Sat 1/311:47 amPTY - MEX
Nonstop3h 43mCopa Airlines
Deal found 12/28![Copa Airlines logo]()
$539
This Mytrip deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:50 pmMEX - PTY
1 stop9h 50mMultiple Airlines
Sat 1/107:50 pmPTY - MEX
3 stops29h 20mMultiple Airlines
Deal found 12/29![Multiple Airlines logo]()
$556
This Copa Airlines deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:30 pmMEX - PTY
Nonstop3h 45mCopa Airlines
Sat 1/109:21 amPTY - MEX
Nonstop3h 49mCopa Airlines
Deal found 12/29![Copa Airlines logo]()
$565
This Kiwi.com deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/303:30 pmMEX - PTY
Nonstop3h 45mCopa Airlines
Sun 1/119:28 pmPTY - MEX
Nonstop3h 47mCopa Airlines
Deal found 12/29![Copa Airlines logo]()
$574
This Gotogate deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:50 pmMEX - PTY
1 stop16h 40mAvianca
Sun 1/119:45 amPTY - MEX
2 stops16h 30mAvianca
Deal found 12/29![Avianca logo]()
$602
Find flight deals from Mexico City to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 30, 2025.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $353 (Gotogate) |
One-way from | $156 (Super.com) |
Popular in | April |
Cheapest in | July |
Average price | $398 |
Good round-trip deal | $362 or less |
Good one-way deal | $244 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Mexico City to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 30, 2025.
Use the filters below to find and compare flights from Mexico City to Panama City that are best for you.
Fly from
Mexico City
Fly to
Panama City
Route
Depart
Return
Price
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Wed 2/11
4:00 am-10:30 am
1 stop5h 30m
Panama City Tocumen Intl
Wed 2/18
2:55 am-12:10 pm
1 stop10h 15m
$358
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Wed 1/21
1:10 pm-5:48 pm
Nonstop3h 38m
Panama City Tocumen Intl
Wed 1/28
11:47 am-2:30 pm
Nonstop3h 43m
$359
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Wed 2/25
5:55 am-10:35 am
Nonstop3h 40m
Panama City Tocumen Intl
Wed 3/4
7:08 pm-10:05 pm
Nonstop3h 57m
$363
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Sun 3/1
11:10 pm-2:00 pm
1 stop13h 50m
Panama City Tocumen Intl
Fri 3/6
2:55 am-12:10 pm
1 stop10h 15m
$363
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Sun 3/29
9:50 am-2:29 pm
Nonstop3h 39m
Panama City Tocumen Intl
Mon 4/6
11:44 am-2:30 pm
Nonstop3h 46m
$363
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Thu 4/16
1:10 pm-5:50 pm
Nonstop3h 40m
Panama City Tocumen Intl
Thu 4/30
9:19 am-12:10 pm
Nonstop3h 51m
$363
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Thu 4/9
3:30 pm-8:10 pm
Nonstop3h 40m
Panama City Tocumen Intl
Sat 4/18
10:11 pm-1:00 am
Nonstop3h 49m
$363
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Thu 2/12
9:25 am-2:06 pm
Nonstop3h 41m
Panama City Tocumen Intl
Thu 2/19
9:21 am-12:10 pm
Nonstop3h 49m
$363
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Tue 2/10
2:00 am-6:41 am
Nonstop3h 41m
Panama City Tocumen Intl
Fri 2/20
9:21 am-12:10 pm
Nonstop3h 49m
$363
Mexico CityPanama City
MEX - PTY
MEXPTY
Mexico City Benito Juarez
Fri 1/30
1:10 pm-5:48 pm
Nonstop3h 38m
Panama City Tocumen Intl
Thu 3/5
7:08 pm-10:05 pm
Nonstop3h 57m
$363
Showing 1-10 of 20 results
Compare providers for flights from Mexico City to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Mexico City to Panama City in December.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Mexico City-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Mexico City-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Mexico City-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Mexico City-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Mexico City-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Mexico City to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mexico City to Panama City
Prices
Airlines
Delays
How far ahead should I book a flight from Mexico City to Panama City?
Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Panama City. Price data was last updated on December 26, 2025.
To ensure you get the cheapest price possible for a flight from Mexico City to Panama City, you should look to book at least 72 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Mexico City to Panama City?
Currently, September is the cheapest month in which you can book a flight from Mexico City to Panama City (average of $175). Flying from Mexico City to Panama City in April is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MEX to PTY?
Find hourly flight availability from Mexico City to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 30, 2025.
One of the essential ways to save on airfare from Mexico City to Panama City is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 23% on airfare.
What is the cheapest day to fly from Mexico City to Panama City?
Use this chart to determine the cheapest time to fly round-trip from Mexico City to Panama City. Price data was last updated on December 27, 2025.
Travelers seeking maximum savings on their Mexico City to Panama City flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.
How often are flights from Mexico City to Panama City delayed?
About 4% of weekly flights between Mexico City and Panama City have experienced delays in the past year, with the average delay time being 134 minutes.
What is the most punctual flight time for Mexico City to Panama City flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Monday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Mexico City to Panama City flights?
Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 4% of flights being delayed.
The best insider tips for Mexico City to Panama City flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Mexico City to Panama City trip
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated December 30, 2025.
Peruse reviews from past customers who have flown with Copa Airlines, Aeromexico, and Avianca from Mexico City to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.4
Food
6.8
Boarding
7.8
Entertainment
6.8
Overall
7.6
Crew
8.1
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Comfort
7.4
Food
6.8
Boarding
7.8
Entertainment
6.8
Overall
7.6
Crew
8.1
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Comfort
7.4
Food
6.8
Boarding
7.8
Entertainment
6.8
Overall
7.6
Crew
8.1
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Comfort
7.4
Food
6.8
Boarding
7.8
Entertainment
6.8
Overall
7.6
Crew
8.1
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Related info for your journey
Find useful and relevant information for your journey from Mexico City to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Top 3 airlines flying from Mexico City to Panama City
Discover the top 3 airlines that operate flights from Mexico City to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 30, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$303 | Average$363 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$329 | Average$428 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$337 | Average$409 | FlexibilityNo cancel fee | On-time71% |