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Panama City

$138+ Cheap flights from Mexico City (MEX) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheapflights Tip: The best prices from Mexico City Benito Juarez to Panama City Tocumen Intl are usually found in July or June, booked 85 days in advance, depart on a Wednesday or Thursday and return on a Tuesday

Cheap flight deals from Mexico City to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2025.

Round-trip from

$310
(Avianca)

One-way from

$138
(FlightHub)

Popular in

October

Cheapest in

July

Average price

$386

Good round-trip deal

$364 or less

Good one-way deal

$260 or less
From Mexico City Benito Juarez to Panama City Tocumen Intl
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One-way flight from Mexico City Benito Juarez to Panama City Tocumen Intl
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Highest demand for flights based on searches. 9% potential increase in price ($43 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Price to beat on a round-trip flight from Mexico City Benito Juarez to Panama City Tocumen Intl.
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Price to beat on a one-way flight from Mexico City Benito Juarez to Panama City Tocumen Intl.
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Find flight deals from Mexico City to Panama City

Cheapest flights from Mexico City to Panama City
Explore the most affordable flight options available from Mexico City to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This Avianca deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/54:55 amMEX - PTY
1 stop15h 15mAvianca
Thu 10/169:55 amPTY - MEX
1 stop14h 05mAvianca
Deal found 8/13$310
This Priceline deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/312:40 amMEX - PTY
1 stop19h 30mAvianca
Fri 10/103:25 amPTY - MEX
1 stop15h 40mAvianca
Deal found 8/13$315
This Avianca deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/611:20 pmMEX - PTY
1 stop16h 10mAvianca
Tue 10/148:10 pmPTY - MEX
1 stop15h 45mAvianca
Deal found 8/13$321
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/173:30 pmMEX - PTY
Nonstop3h 44mCopa Airlines
Sun 9/219:21 amPTY - MEX
Nonstop3h 49mCopa Airlines
Deal found 8/12$324
This Priceline deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/184:50 pmMEX - PTY
1 stop16h 35mAvianca
Thu 9/259:55 amPTY - MEX
1 stop14h 05mAvianca
Deal found 8/12$326
This Copa Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/131:05 pmMEX - PTY
Nonstop3h 44mCopa Airlines
Sat 9/2010:21 pmPTY - MEX
Nonstop3h 39mCopa Airlines
Deal found 8/14$329
This deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/167:40 amMEX - PTY
Nonstop3h 59mAeromexico
Wed 9/242:44 pmPTY - MEX
Nonstop3h 56mAeromexico
Deal found 8/14$330
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/194:55 amMEX - PTY
1 stop10h 35mAvianca
Fri 9/2611:00 amPTY - MEX
1 stop13h 00mAvianca
Deal found 8/12$331
This Avianca deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/284:20 amMEX - PTY
1 stop9h 30mAvianca
Sat 12/69:45 amPTY - MEX
1 stop9h 25mAvianca
Deal found 8/13$335
This Copa Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/22:00 amMEX - PTY
Nonstop3h 44mCopa Airlines
Mon 10/1311:42 amPTY - MEX
Nonstop3h 48mCopa Airlines
Deal found 8/14$342

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Mexico City to Panama City that are best for you.

Fly from

Mexico City

Fly to

Panama City

Route

Depart

Return

Price

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 11/10

4:20 am-2:50 pm

1 stop9h 30m

Panama City Tocumen Intl

Sun 11/23

3:35 pm-1:15 am

1 stop10h 40m

$310

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sun 10/5

4:55 am-9:10 pm

1 stop15h 15m

Panama City Tocumen Intl

Thu 10/16

9:55 am-11:00 pm

1 stop14h 05m

$310

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 10/3

12:40 am-9:10 pm

1 stop19h 30m

Panama City Tocumen Intl

Fri 10/10

3:25 am-6:05 pm

1 stop15h 40m

$315

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 10/6

11:20 pm-4:30 pm

1 stop16h 10m

Panama City Tocumen Intl

Tue 10/14

8:10 pm-10:55 am

1 stop15h 45m

$321

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 9/17

3:30 pm-8:14 pm

Nonstop3h 44m

Panama City Tocumen Intl

Sun 9/21

9:21 am-12:10 pm

Nonstop3h 49m

$324

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 9/18

3:30 pm-8:14 pm

Nonstop3h 44m

Panama City Tocumen Intl

Sun 9/21

10:21 pm-1:00 am

Nonstop3h 39m

$324

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 9/17

1:05 pm-5:49 pm

Nonstop3h 44m

Panama City Tocumen Intl

Mon 9/22

10:21 pm-1:00 am

Nonstop3h 39m

$324

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 9/18

3:30 pm-8:14 pm

Nonstop3h 44m

Panama City Tocumen Intl

Mon 9/22

10:21 pm-1:00 am

Nonstop3h 39m

$324

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 9/22

11:20 pm-8:55 am

1 stop8h 35m

$138

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 8/30

4:55 am-4:30 pm

1 stop10h 35m

$141

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Showing 1-10 of 16 results
1
2

The best insider tips for Mexico City to Panama City flights

Snippets provided in this section are AI-generated based on a summarization of Cheapflights-commissioned articles. The articles are presented as-is, for general informational purposes only, and may not be up-to-date. The opinions contained in the articles are original to the author and reflect their authentic experience, which may vary significantly from the experience of others.
Cheapflights partnered with top experts to bring you the best recommendations for your Mexico City to Panama City trip
Airports
MEX

Security lines at MEX are efficient, usually under 20 minutes, but arrive early for US-bound flights due to additional checks.

Read more about MEXby Brandon Schultz
PTY

At PTY, Uber is the fastest and often cheapest transport to Panama City, more reliable than taxis.

Read more about PTYby Taryn White
Our travel experts
Brandon Schultz

Brandon Schultz

Expert on MEX

Brandon Schultz

Brandon Schultz

Brandon Schultz is an award-winning food and travel writer based in New York City. His work has appeared in Forbes, AAA, Thrillist, Travel + Leisure, and The Daily Meal, among many others, and he is the author of 6 books, including 3 cookbooks.

Read more
Taryn White

Taryn White

Expert on PTY

Taryn White

Taryn White

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Read more

Best time to book a flight from Mexico City to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Panama City

How far ahead should I book a flight from Mexico City to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Panama City. Price data was last updated on August 8, 2025.

To ensure you get the cheapest price possible for a flight from Mexico City to Panama City, you should look to book at least 85 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Mexico City to Panama City?

Currently, October is the cheapest month in which you can book a flight from Mexico City to Panama City (average of $478). Flying from Mexico City to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PTY?

Find hourly flight availability from Mexico City to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

One of the essential ways to save on airfare from Mexico City to Panama City is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 18% on airfare.

What is the cheapest day to fly from Mexico City to Panama City?

Use this chart to determine the cheapest time to fly round-trip from Mexico City to Panama City. Price data was last updated on August 10, 2025.

Travelers seeking maximum savings on their Mexico City to Panama City flight should consider departing on Wednesday evenings when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Mexico City to Panama City

Explore weekly flight availability from Mexico City to Panama City. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 14, 2025.

The most flights from MEX to PTY are scheduled on a Thursday (9 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (4 on average).

How much does it cost to fly round-trip from Mexico City to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated August 14, 2025.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Mexico City to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,509 reviews

Overall

7.5

Entertainment

6.8

Crew

8.1

Boarding

7.8

Food

6.8

Comfort

7.4

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
Copa Airlines
7.5
Good
1,509 reviews
Copa Airlines
7.5
Good
1,509 reviews

Overall

7.5

Entertainment

6.8

Crew

8.1

Boarding

7.8

Food

6.8

Comfort

7.4

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
Avianca
6.7
Okay
2,399 reviews
Copa Airlines
7.5
Good
1,509 reviews

Overall

7.5

Entertainment

6.8

Crew

8.1

Boarding

7.8

Food

6.8

Comfort

7.4

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Mexico City to Panama City?

    Panama City Tocumen Intl is the airport most travelers will use when flying to Panama City from Mexico City Benito Juarez. Booking flights from Benito Juarez (MEX) to Tocumen Intl (PTY) should be relatively easy as there are 7 daily flights to Panama City from 2 different airlines. 3h 44m is how long a flight from Mexico City to Panama City Tocumen Intl will take if you book a nonstop flight.

  • How popular is this Mexico City to Panama City flight route?

    Within the past month, 19 users have taken a look at flights from Mexico City Benito Juarez to Panama City Tocumen Intl.

  • What are the cheapest airlines flying from Mexico City to Panama City round-trip?

    Our cheapest airline available from Mexico City to Panama City is Avianca. Our recent data shows that you can find tickets from as low as $343 on this airline. An additional option worth looking into is Copa Airlines, starting at $378. You may be able to fly from Mexico City to Panama City for 19% less than the average price by searching for these airlines.

  • What are the most reliable airlines from Mexico City to Panama City?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mexico City to Panama City on time: Emirates (98%), Copa Airlines (96%), Aeromexico (92%).

  • What are the cheapest flights from Mexico City to Panama City?

    The cheapest flight price from Mexico City to Panama City is $165. On average you can expect to pay $558. The most popular route, (Mexico City Benito Juarez - Panama City Tocumen Intl), can usually be booked for $314.

  • Can I find deals for flights from Mexico City to Panama City that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama City.

  • Can I find deals for business class flights from Mexico City to Panama City?

    Yes. Cheapflights offers flight deals from Mexico City to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Mexico City to Panama City (average of $478). Flying from Mexico City to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 2 airlines flying from Mexico City to Panama City

Discover the top 2 airlines that operate flights from Mexico City to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$343Average$473FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$378Average$474FlexibilityNo cancel feeOn-time70%

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