$160+ Cheap flights from Mexico City (MEX) to Panama
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/1. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
Oct 29 — Nov 51
Round-trip
1 adult, Economy
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Find cheap flights from Mexico City to Panama with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mexico City to Panama
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Last-minute
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Cheapest flights from Mexico City to PanamaExplore the most affordable flight options available from Mexico City to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2026.
Explore the most affordable flight options available from Mexico City to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:50 am -
Nonstop3h 56m
Fri 11/272:47 pm -
Nonstop3h 53m
Deal found 9/27![Aeromexico logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:50 am -
Nonstop3h 56m
Sat 11/142:47 pm -
Nonstop3h 53m
Deal found 9/28![Aeromexico logo]()
$350
This Trip.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:50 am -
Nonstop3h 56m
Tue 11/32:47 pm -
Nonstop3h 53m
Deal found 9/27![Aeromexico logo]()
$352
This Trip.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/238:50 am -
Nonstop3h 56m
Mon 11/302:47 pm -
Nonstop3h 53m
Deal found 9/27![Aeromexico logo]()
$353
This Trip.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:50 am -
Nonstop3h 56m
Sat 11/72:47 pm -
Nonstop3h 53m
Deal found 9/29![Aeromexico logo]()
$355
This Trip.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:50 am -
Nonstop3h 56m
Fri 12/42:47 pm -
Nonstop3h 53m
Deal found 9/28![Aeromexico logo]()
$356
This Kiwi.com deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:50 am -
Nonstop3h 56m
Wed 12/22:47 pm -
Nonstop3h 53m
Deal found 9/26![Aeromexico logo]()
$357
This Trip.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/158:50 am -
Nonstop3h 56m
Sun 11/222:47 pm -
Nonstop3h 53m
Deal found 9/24![Aeromexico logo]()
$358
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:55 am -
Nonstop3h 52m
Sat 11/289:24 am -
Nonstop3h 46m
Deal found 9/25![Copa Airlines logo]()
$361
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/211:20 am -
Nonstop3h 44m
Sun 11/299:31 pm -
Nonstop3h 44m
Deal found 9/28![Copa Airlines logo]()
$362
Best flights from Mexico City to PanamaDiscover carefully curated flight deals from Mexico City to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2026.
Discover carefully curated flight deals from Mexico City to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2026.
This Copa Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/231:20 am -
Nonstop3h 41m
Tue 11/310:17 pm -
Nonstop3h 43m
Deal found 9/26![Copa Airlines logo]()
$395
This Copa Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:30 pm -
Nonstop3h 44m
Sat 11/74:29 pm -
Nonstop3h 51m
Deal found 9/25![Copa Airlines logo]()
$395
This Copa Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/265:55 am -
Nonstop3h 43m
Fri 3/264:16 pm -
Nonstop4h 04m
Deal found 9/24![Copa Airlines logo]()
$408
This Copa Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/202:10 am -
Nonstop3h 41m
Sun 11/84:29 pm -
Nonstop3h 51m
Deal found 9/24![Copa Airlines logo]()
$420
This Copa Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/55:55 am -
Nonstop3h 45m
Sun 2/711:44 am -
Nonstop3h 46m
Deal found 9/24![Copa Airlines logo]()
$420
This Copa Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/119:10 am -
Nonstop3h 44m
Wed 3/1711:37 am -
Nonstop3h 53m
Deal found 9/24![Copa Airlines logo]()
$420
This Copa Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/151:10 pm -
Nonstop3h 44m
Wed 10/2110:13 pm -
Nonstop3h 47m
Deal found 9/26![Copa Airlines logo]()
$420
This Copa Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/112:10 am -
Nonstop3h 41m
Sun 10/1810:13 pm -
Nonstop3h 47m
Deal found 9/29![Copa Airlines logo]()
$523
Last-minute flights from Mexico City to PanamaDiscover last-minute flight deals from Mexico City to Panama. Data last updated September 29, 2026 and is based on user searches.
Discover last-minute flight deals from Mexico City to Panama. Data last updated September 29, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/89:05 am -
Nonstop3h 50m
Thu 10/153:05 pm -
Nonstop3h 55m
Deal found 9/28![Aeromexico logo]()
$379
This Avianca deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2512:30 am -
1 stop7h 40m
Mon 11/25:30 am -
1 stop6h 30m
Deal found 9/28![Avianca logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/261:20 am -
Nonstop3h 41m
Tue 11/310:17 pm -
Nonstop3h 43m
Deal found 9/29![Copa Airlines logo]()
$363
This Trip.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:50 am -
Nonstop3h 56m
Tue 11/32:47 pm -
Nonstop3h 53m
Deal found 9/27![Aeromexico logo]()
$352
This Avianca deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:20 pm -
1 stop8h 50m
Tue 11/34:10 pm -
1 stop7h 45m
Deal found 9/29![Avianca logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:20 am -
Nonstop3h 41m
Thu 11/59:31 pm -
Nonstop3h 44m
Deal found 9/28![Copa Airlines logo]()
$365
This Trip.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:50 am -
Nonstop3h 56m
Thu 11/52:47 pm -
Nonstop3h 53m
Deal found 9/27![Aeromexico logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:00 am -
Nonstop3h 41m
Fri 11/610:17 pm -
Nonstop3h 43m
Deal found 9/27![Copa Airlines logo]()
$374
This Trip.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:50 am -
Nonstop3h 56m
Sat 11/72:47 pm -
Nonstop3h 53m
Deal found 9/29![Aeromexico logo]()
$355
One-way flights from Mexico City to PanamaSearch for one-way flight options from Mexico City to Panama. Find affordable one-way fares based on user searches. Data last updated September 29, 2026.
Search for one-way flight options from Mexico City to Panama. Find affordable one-way fares based on user searches. Data last updated September 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/18:45 am -
Nonstop3h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Aeromexico logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/318:45 am -
Nonstop3h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Aeromexico logo]()
$162
This Copa Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/19:10 am -
Nonstop3h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Copa Airlines logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/28:45 am -
Nonstop3h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Aeromexico logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/48:55 am -
Nonstop3h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Aeromexico logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/303:30 pm -
Nonstop3h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Copa Airlines logo]()
$186
This Cheapflightsfares deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/148:50 am -
Nonstop3h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Aeromexico logo]()
$209
This Super.com deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/151:10 pm -
Nonstop3h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Copa Airlines logo]()
$216
This Copa Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/273:25 am -
Nonstop3h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Copa Airlines logo]()
$219
This Cheapflightsfares deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/218:50 am -
Nonstop3h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Aeromexico logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/158:50 am -
Nonstop3h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Aeromexico logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/138:50 am -
Nonstop3h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Aeromexico logo]()
$245
Find flight deals from Mexico City to Panama
Keep the following information in mind while searching for Mexico City to Panama flight deals. Data was last updated September 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $349 (Kiwi.com) |
One-way from | $209 (Cheapflightsfares) |
Popular in | July |
Cheapest in | February |
Average price | $429 |
Good round-trip deal | $375 or less |
Good one-way deal | $272 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Mexico City to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 29, 2026.
Use the filters below to find and compare flights from Mexico City to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Thu 12/31
1:20 am-6:00 am
Nonstop3h 40m
Panama City Tocumen Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$170
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Fri 10/16
5:50 am-10:41 am
Nonstop3h 51m
Panama City Tocumen Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$219
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Wed 10/21
2:10 am-6:51 am
Nonstop3h 41m
Panama City Tocumen Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$219
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Tue 10/27
3:25 am-8:06 am
Nonstop3h 41m
Panama City Tocumen Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$219
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Wed 12/9
2:00 am-6:42 am
Nonstop3h 42m
Panama City Tocumen Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$253
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Tue 11/24
1:10 pm-5:59 pm
Nonstop3h 49m
Panama City Tocumen Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$253
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Mon 11/23
1:10 pm-5:59 pm
Nonstop3h 49m
Panama City Tocumen Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$253
Quickest round-trip
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Thu 2/25
3:25 am-8:02 am
Nonstop3h 37m
Panama City Tocumen Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$253
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Tue 11/24
1:20 am-6:04 am
Nonstop3h 44m
Panama City Tocumen Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$253
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Fri 10/23
1:20 am-6:01 am
Nonstop3h 41m
Panama City Tocumen Intl
Tue 11/3
10:17 pm-1:00 am
Nonstop3h 43m
$395
Showing 1-10 of 20 resultsSorted by cheapest first
Best time to book a flight from Mexico City to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Mexico City with our price prediction graph.
MEX-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mexico City to Panama
MEX-PA0
MEX-PTY
What is the cheapest month to book a flight from Mexico City to Panama?
Currently, February is the cheapest month in which you can book a flight from Mexico City to Panama (average of $360). Flying from Mexico City to Panama in July is currently the most expensive (average of $445). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MEX to PA?
Find hourly flight availability from Mexico City to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 29, 2026.
It’s typically best to fly out from Mexico City to Panama in the evening. Doing so could potentially save you 14% on the flight price compared to flying at noon, which is usually more expensive.
Weekly flight availability from Mexico City to Panama
Explore weekly flight availability from Mexico City to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 29, 2026.
The most flights from MEX to PA0 are scheduled on a Tuesday (9 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (5 on average).
How often are flights from Mexico City to Panama delayed?
About 4% of weekly flights between Mexico City and Panama have experienced delays in the past year, with the average delay time being 117 minutes.
What is the most punctual flight time for Mexico City to Panama flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Saturday tends to have the lowest number of delays on this route, whereas Wednesday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Mexico City to Panama flights?
Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 4% of flights being delayed.
How far ahead should I book a flight from Mexico City to Panama?
The price you pay for your flight from Mexico City to Panama may vary depending on when you book. For the best chance of a lower fare, look to book 54 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest day to fly from Mexico City to Panama?
Use this chart to determine the cheapest time to fly round-trip from Mexico City to Panama. Price data was last updated on September 26, 2026.
Travelers seeking maximum savings on their Mexico City to Panama flight should consider departing on Monday evenings when fares are most often at their lowest. Saturday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing Panama
Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated September 29, 2026.
Peruse reviews from past customers who have flown with Copa Airlines,Aeromexico, andAvianca from Mexico City to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.4
Entertainment
6.9
Crew
8.1
Food
6.9
Boarding
7.8
Overall
7.6
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2026
BOS - PTY
Comfort
7.4
Entertainment
6.9
Crew
8.1
Food
6.9
Boarding
7.8
Overall
7.6
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2026
BOS - PTY
Comfort
7.4
Entertainment
6.9
Crew
8.1
Food
6.9
Boarding
7.8
Overall
7.6
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2026
BOS - PTY
Comfort
7.4
Entertainment
6.9
Crew
8.1
Food
6.9
Boarding
7.8
Overall
7.6
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2026
BOS - PTY
Related info for your journey
Find useful and relevant information for your journey from Mexico City to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Top 3 airlines flying from Mexico City to Panama
Discover the top 3 airlines that operate flights from Mexico City to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$212 | Average$439 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$226 | Average$380 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$337 | Average$409 | FlexibilityNo cancel fee | On-time71% |