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Panama City

$238+ Cheap flights from Buffalo (BUF) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/18. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — PTY
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Buffalo to Panama City

Cheapest flights from Buffalo to Panama City
Explore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This KAYAK deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2911:40 am
BUF
-
PTY
1 stop17h 24m
Multiple Airlines
Sat 8/89:45 am
PTY
-
BUF
1 stop11h 52m
Multiple Airlines
Deal found 1/28$539
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/65:27 pm
BUF
-
PTY
2 stops20h 00m
American Airlines
Wed 2/112:27 pm
PTY
-
BUF
2 stops20h 31m
American Airlines
Deal found 1/27$543
This Ovago deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:00 am
BUF
-
PTY
1 stop14h 31m
Copa Airlines
Sat 8/89:45 am
PTY
-
BUF
2 stops23h 02m
Copa Airlines
Deal found 1/28$563
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:11 pm
BUF
-
PTY
2 stops18h 59m
American Airlines
Sat 8/83:20 pm
PTY
-
BUF
2 stops18h 34m
American Airlines
Deal found 1/28$579
This Expedia deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:58 pm
BUF
-
PTY
2 stops39h 32m
Multiple Airlines
Mon 3/303:50 pm
PTY
-
BUF
2 stops15h 16m
Multiple Airlines
Deal found 1/29$608
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:00 am
BUF
-
PTY
2 stops12h 37m
United Airlines
Wed 8/263:20 pm
PTY
-
BUF
2 stops22h 56m
United Airlines
Deal found 1/28$620
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/55:30 am
BUF
-
PTY
2 stops10h 31m
American Airlines
Fri 4/101:49 pm
PTY
-
BUF
2 stops23h 30m
American Airlines
Deal found 1/28$645
This Expedia deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/147:57 pm
BUF
-
PTY
2 stops15h 33m
Multiple Airlines
Sat 3/217:50 pm
PTY
-
BUF
2 stops36h 14m
Multiple Airlines
Deal found 1/27$688
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/56:00 am
BUF
-
PTY
1 stop7h 55m
Delta
Tue 2/103:20 pm
PTY
-
BUF
1 stop8h 08m
Delta
Deal found 1/26$732
This KAYAK deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/276:00 am
BUF
-
PTY
1 stop23h 10m
Azul
Mon 3/3010:55 pm
PTY
-
BUF
1 stop23h 38m
Azul
Deal found 1/29$828
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/66:00 am
BUF
-
PTY
1 stop7h 55m
Delta
Wed 2/113:20 pm
PTY
-
BUF
1 stop8h 08m
Delta
Deal found 1/27$833

Find flight deals from Buffalo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$645
(American Airlines)

One-way from

$238
(United Airlines)

Popular in

August

Cheapest in

April

Average price

$622
Provider with most accurate pricing for Buffalo-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Panama City Tocumen Intl flights.
Search Deals
From Buffalo to Panama City Tocumen Intl
Search Deals
One-way flight from Buffalo to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($9 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Buffalo to Panama City that are best for you.

Fly from

Buffalo

Fly to

Panama City

Route

Depart

Return

Price

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 3/27

7:58 pm-10:30 am

2 stops39h 32m

Panama City Tocumen Intl

Mon 3/30

3:50 pm-8:06 am

2 stops15h 16m

$608

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sun 4/5

5:30 am-3:01 pm

2 stops10h 31m

Panama City Tocumen Intl

Fri 4/10

1:49 pm-2:19 pm

2 stops23h 30m

$645

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 3/14

7:57 pm-10:30 am

2 stops15h 33m

Panama City Tocumen Intl

Sat 3/21

7:50 pm-9:04 am

2 stops36h 14m

$688

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 3/27

6:00 am-4:10 am

1 stop23h 10m

Panama City Tocumen Intl

Mon 3/30

10:55 pm-11:33 pm

1 stop23h 38m

$828

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 3/14

7:00 am-4:10 am

2 stops22h 10m

Panama City Tocumen Intl

Sat 3/21

10:55 pm-9:48 am

1 stop9h 53m

$849

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sun 4/5

2:54 pm-4:04 am

2 stops14h 10m

Panama City Tocumen Intl

Fri 4/10

10:55 pm-10:02 am

1 stop10h 07m

$949

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sun 4/5

8:59 pm-10:30 am

2 stops14h 31m

Panama City Tocumen Intl

Fri 4/10

11:25 am-8:06 am

3 stops19h 41m

$962

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 6/18

5:47 pm-6:37 pm

2 stops25h 50m

$238

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 6/18

6:00 am-1:05 pm

1 stop8h 05m

$502

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 6/18

12:11 pm-2:00 pm

3 stops50h 49m

$851

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 11 results
1
2

Compare providers for flights from Buffalo to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Panama City in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Panama City

What is the cheapest month to book a flight from Buffalo to Panama City?

Currently, May is the cheapest month in which you can book a flight from Buffalo to Panama City (average of $240). Flying from Buffalo to Panama City in June is currently the most expensive (average of $638). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Buffalo to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated January 29, 2026.
Read through reviews of airlines operating flights from Buffalo to Panama City, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Panama City?

    American Airlines and Azul can get you from Buffalo to Panama City in just under 10h 31m. Your travel time can differ by up to 12h 39m. Airlines will cover a distance of 2339 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Buffalo to Panama City round-trip?

    Delta, at $497, was found to be the cheapest airline from Buffalo to Panama City.. Delta is currently priced 17% below the average price you’ll pay for this route.

  • Can I find deals for flights from Buffalo to Panama City that include hotel bookings?

    Yes. In addition to deals on Buffalo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Panama City.

  • Can I find deals for business class flights from Buffalo to Panama City?

    Yes. Cheapflights offers flight deals from Buffalo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Panama City?

    Currently, May is the cheapest month in which you can book a flight from Buffalo to Panama City (average of $240). Flying from Buffalo to Panama City in June is currently the most expensive (average of $638). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Buffalo to Panama City

Discover the top airline that operate flights from Buffalo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$497Average$632FlexibilityNo cancel feeOn-timeN/A

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