$249+ Cheap flights from Buffalo (BUF) to Panama City (PTY)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — PTY
Apr 16 — Apr 231
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Panama City
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Cheapest flights from Buffalo to Panama CityExplore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.
Explore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2910:41 am
BUF
- PTY
2 stops24h 49m
Multiple Airlines
Wed 5/63:50 pm
PTY
- BUF
2 stops28h 35m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$548
This Expedia deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:59 pm
BUF
- PTY
2 stops15h 31m
Multiple Airlines
Sat 9/193:50 pm
PTY
- BUF
2 stops16h 04m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$560
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/308:01 pm
BUF
- PTY
2 stops15h 29m
Multiple Airlines
Thu 5/73:50 pm
PTY
- BUF
2 stops28h 35m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$567
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:36 am
BUF
- PTY
1 stop9h 58m
Multiple Airlines
Tue 5/1210:26 am
PTY
- BUF
1 stop26h 28m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$590
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:39 pm
BUF
- PTY
2 stops15h 51m
Multiple Airlines
Tue 5/193:50 pm
PTY
- BUF
2 stops16h 10m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$598
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/251:11 pm
BUF
- PTY
1 stop8h 23m
Multiple Airlines
Sat 5/210:26 am
PTY
- BUF
1 stop24h 11m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$607
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/912:25 pm
BUF
- PTY
2 stops23h 05m
Multiple Airlines
Wed 5/133:50 pm
PTY
- BUF
2 stops28h 35m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$612
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
BUF
- PTY
2 stops31h 02m
Delta
Sat 5/22:27 pm
PTY
- BUF
2 stops18h 04m
Delta
Deal found 3/12![Delta logo]()
$613
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:59 pm
BUF
- PTY
2 stops18h 47m
American Airlines
Tue 5/121:49 pm
PTY
- BUF
2 stops19h 29m
American Airlines
Deal found 3/15![American Airlines logo]()
$627
Best flights from Buffalo to Panama CityDiscover carefully curated flight deals from Buffalo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 17, 2026.
Discover carefully curated flight deals from Buffalo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 17, 2026.
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/308:01 pm
BUF
- PTY
2 stops15h 29m
Multiple Airlines
Thu 5/73:50 pm
PTY
- BUF
2 stops28h 35m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$567
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2510:45 am
BUF
- PTY
1 stop9h 46m
United Airlines
Sat 5/23:30 pm
PTY
- BUF
2 stops17h 11m
United Airlines
Deal found 3/12![United Airlines logo]()
$613
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
BUF
- PTY
2 stops31h 02m
Delta
Sat 5/22:27 pm
PTY
- BUF
2 stops18h 04m
Delta
Deal found 3/12![Delta logo]()
$613
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:36 am
BUF
- PTY
1 stop9h 58m
Multiple Airlines
Tue 5/1210:26 am
PTY
- BUF
1 stop26h 28m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$590
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:52 pm
BUF
- PTY
2 stops21h 22m
United Airlines
Fri 6/1910:55 pm
PTY
- BUF
2 stops21h 08m
United Airlines
Deal found 3/12![United Airlines logo]()
$613
This United Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:02 pm
BUF
- PTY
1 stop10h 02m
United Airlines
Wed 5/133:30 pm
PTY
- BUF
2 stops17h 11m
United Airlines
Deal found 3/15![United Airlines logo]()
$633
This United Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3010:31 am
BUF
- PTY
1 stop10h 00m
United Airlines
Thu 5/73:30 pm
PTY
- BUF
2 stops17h 10m
United Airlines
Deal found 3/15![United Airlines logo]()
$633
This United Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:55 pm
BUF
- PTY
1 stop10h 09m
United Airlines
Wed 5/69:45 am
PTY
- BUF
2 stops22h 56m
United Airlines
Deal found 3/15![United Airlines logo]()
$633
This United Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:02 pm
BUF
- PTY
1 stop10h 02m
United Airlines
Tue 5/199:45 am
PTY
- BUF
2 stops13h 10m
United Airlines
Deal found 3/15![United Airlines logo]()
$633
This United Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/2410:40 am
BUF
- PTY
2 stops18h 24m
United Airlines
Thu 5/287:55 am
PTY
- BUF
2 stops25h 10m
United Airlines
Deal found 3/15![United Airlines logo]()
$633
Last-minute flights from Buffalo to Panama CityDiscover last-minute flight deals from Buffalo to Panama City. Data last updated March 17, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Panama City. Data last updated March 17, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/297:40 pm
BUF
- PTY
2 stops20h 21m
American Airlines
Sun 4/53:51 pm
PTY
- BUF
2 stops18h 58m
American Airlines
Deal found 3/15![American Airlines logo]()
$819
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/251:11 pm
BUF
- PTY
1 stop8h 23m
Multiple Airlines
Sat 5/210:26 am
PTY
- BUF
1 stop24h 11m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$607
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
BUF
- PTY
2 stops31h 02m
Delta
Sat 5/22:27 pm
PTY
- BUF
2 stops18h 04m
Delta
Deal found 3/12![Delta logo]()
$613
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2710:30 am
BUF
- PTY
1 stop10h 01m
United Airlines
Mon 5/47:55 am
PTY
- BUF
2 stops12h 06m
United Airlines
Deal found 3/12![United Airlines logo]()
$690
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2910:41 am
BUF
- PTY
2 stops24h 49m
Multiple Airlines
Wed 5/63:50 pm
PTY
- BUF
2 stops28h 35m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$548
This Delta deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:00 am
BUF
- PTY
1 stop8h 02m
Delta
Wed 5/62:27 pm
PTY
- BUF
1 stop8h 10m
Delta
Deal found 3/15![Delta logo]()
$629
This United Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2910:55 am
BUF
- PTY
2 stops18h 09m
United Airlines
Wed 5/63:30 pm
PTY
- BUF
2 stops17h 11m
United Airlines
Deal found 3/15![United Airlines logo]()
$633
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/308:01 pm
BUF
- PTY
2 stops15h 29m
Multiple Airlines
Thu 5/73:50 pm
PTY
- BUF
2 stops28h 35m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$567
One-way flights from Buffalo to Panama CitySearch for one-way flight options from Buffalo to Panama City. Find affordable one-way fares based on user searches. Data last updated March 17, 2026.
Search for one-way flight options from Buffalo to Panama City. Find affordable one-way fares based on user searches. Data last updated March 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1612:35 pm
BUF
- PTY
3 stops37h 00m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$249
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:52 pm
BUF
- PTY
2 stops21h 22m
United Airlines
Deal found 3/13![United Airlines logo]()
$267
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1510:31 am
BUF
- PTY
1 stop10h 00m
United Airlines
Deal found 3/12![United Airlines logo]()
$272
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1510:34 am
BUF
- PTY
1 stop9h 57m
United Airlines
Deal found 3/13![United Airlines logo]()
$282
This Expedia deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:05 am
BUF
- PTY
3 stops32h 50m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$317
This FlightHub deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:55 pm
BUF
- PTY
2 stops16h 20m
Avianca
Deal found 3/13![Avianca logo]()
$553
This Avianca deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1810:34 am
BUF
- PTY
3 stops29h 21m
Avianca
Deal found 3/16![Avianca logo]()
$595
Find flight deals from Buffalo to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $548 (Expedia) |
One-way from | $249 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
Use the filters below to find and compare flights from Buffalo to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Thu 4/30
8:01 pm-10:30 am
2 stops15h 29m
Panama City Tocumen Intl
Thu 5/7
3:50 pm-9:25 pm
2 stops28h 35m
$567
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Tue 5/5
11:36 am-8:34 pm
1 stop9h 58m
Panama City Tocumen Intl
Tue 5/12
10:26 am-1:54 pm
1 stop26h 28m
$590
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Sat 4/25
10:45 am-7:31 pm
1 stop9h 46m
Panama City Tocumen Intl
Sat 5/2
3:30 pm-9:41 am
2 stops17h 11m
$613
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Sat 4/25
7:00 am-1:02 pm
2 stops31h 02m
Panama City Tocumen Intl
Sat 5/2
2:27 pm-9:31 am
2 stops18h 04m
$613
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Tue 6/16
5:52 pm-2:14 pm
2 stops21h 22m
Panama City Tocumen Intl
Fri 6/19
10:55 pm-9:03 pm
2 stops21h 08m
$613
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Sat 5/9
7:02 pm-4:04 am
1 stop10h 02m
Panama City Tocumen Intl
Wed 5/13
3:30 pm-9:41 am
2 stops17h 11m
$633
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Thu 4/30
10:31 am-7:31 pm
1 stop10h 00m
Panama City Tocumen Intl
Thu 5/7
3:30 pm-9:40 am
2 stops17h 10m
$633
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Wed 4/29
6:55 pm-4:04 am
1 stop10h 09m
Panama City Tocumen Intl
Wed 5/6
9:45 am-9:41 am
2 stops22h 56m
$633
Quickest round-trip
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Sat 5/16
7:02 pm-4:04 am
1 stop10h 02m
Panama City Tocumen Intl
Tue 5/19
9:45 am-11:55 pm
2 stops13h 10m
$633
BuffaloPanama City
BUF - PTY
BUFPTY
Buffalo
Sun 5/24
10:40 am-4:04 am
2 stops18h 24m
Panama City Tocumen Intl
Thu 5/28
7:55 am-10:05 am
2 stops25h 10m
$633
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Buffalo to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Panama City in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Buffalo with our price prediction graph.
BUF-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated March 17, 2026.
Read through reviews of airlines operating flights from Buffalo to Panama City, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentKymberlee,Oct 2024
JFK - ATL
Overall
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentKymberlee,Oct 2024
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Buffalo to Panama City
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Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Buffalo to Panama City by cabin class
Find flights from Buffalo to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and Panama City flights
Browse other Buffalo and Panama City flight options. Last updated on March 17, 2026.
Other flights from Buffalo
Browse through other flights departing from Buffalo. Flights are based on user searches made on Cheapflights and were last updated on March 17, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Buffalo to Panama City
Discover the top airline that operate flights from Buffalo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$461 | Average$671 | FlexibilityNo cancel fee | On-timeN/A |