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Panama City

$145+ Cheap flights from St. Louis to Panama City, FL (STL - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/8. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ECP
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Panama City NW Florida Beaches are usually found in October or December, booked 88 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Cheap flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This Southwest deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2410:15 amSTL - ECP
1 stop5h 35mSouthwest
Mon 12/296:35 pmECP - STL
1 stop5h 30mSouthwest
Deal found 12/9$389
This Delta deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:00 amSTL - ECP
1 stop6h 19mDelta
Sun 12/289:22 amECP - STL
1 stop5h 08mDelta
Deal found 12/11$405
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:30 amSTL - ECP
2 stops9h 40mUnited Airlines
Sun 12/284:45 pmECP - STL
1 stop5h 10mUnited Airlines
Deal found 12/11$410
This Southwest deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:45 amSTL - ECP
2 stops9h 20mSouthwest
Sun 12/286:35 pmECP - STL
1 stop5h 30mSouthwest
Deal found 12/10$434
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:15 amSTL - ECP
1 stop7h 43mUnited Airlines
Wed 12/1711:05 amECP - STL
1 stop4h 59mUnited Airlines
Deal found 12/10$451
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:30 amSTL - ECP
2 stops9h 40mUnited Airlines
Mon 12/296:15 amECP - STL
2 stops13h 03mUnited Airlines
Deal found 12/9$465
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:35 pmSTL - ECP
1 stop5h 18mAmerican Airlines
Mon 12/223:28 pmECP - STL
1 stop7h 28mAmerican Airlines
Deal found 12/11$467

Find flight deals from St. Louis to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$289
(Delta)

One-way from

$145
(Delta)

Popular in

March

Cheapest in

October

Average price

$302
Provider with most accurate pricing for Lambert-St Louis-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City NW Florida Beaches flights.
Search Deals
From Lambert-St Louis to Panama City NW Florida Beaches
Search Deals
One-way flight from Lambert-St Louis to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($66 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

St. Louis

Fly to

Panama City

Route

Depart

Return

Price

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 3/19

5:45 am-12:50 pm

1 stop7h 05m

Panama City NW Florida Beaches

Mon 3/23

4:55 pm-9:00 pm

1 stop4h 05m

$289

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 5/27

11:00 am-4:17 pm

1 stop5h 17m

Panama City NW Florida Beaches

Tue 6/2

11:10 am-4:35 pm

1 stop5h 25m

$289

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 1/25

6:57 pm-10:40 pm

1 stop3h 43m

Panama City NW Florida Beaches

Sun 2/1

7:20 am-11:04 am

1 stop3h 44m

$289

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Fri 1/30

6:00 am-1:04 pm

1 stop7h 04m

Panama City NW Florida Beaches

Fri 1/30

6:03 pm-11:12 pm

1 stop5h 09m

$289

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 4/9

4:10 pm-9:40 pm

1 stop5h 30m

Panama City NW Florida Beaches

Mon 4/13

5:00 pm-10:45 pm

1 stop5h 45m

$289

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 1/11

6:00 am-12:02 pm

1 stop6h 02m

Panama City NW Florida Beaches

Thu 1/15

4:54 pm-10:00 pm

1 stop5h 06m

$289

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 1/25

9:59 am-2:56 pm

1 stop4h 57m

Panama City NW Florida Beaches

Sat 1/31

1:10 pm-7:27 pm

1 stop6h 17m

$289

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Fri 2/27

5:00 am-11:55 am

1 stop6h 55m

Panama City NW Florida Beaches

Mon 3/2

4:30 pm-8:10 pm

1 stop3h 40m

$289

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 1/8

6:00 am-12:02 pm

1 stop6h 02m

Panama City NW Florida Beaches

Mon 1/12

4:54 pm-10:00 pm

1 stop5h 06m

$289

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 5/27

7:20 am-12:38 pm

1 stop5h 18m

Panama City NW Florida Beaches

Tue 6/2

7:45 am-12:54 pm

1 stop5h 09m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/9

Showing 1-10 of 23 results
1
2
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Compare providers for flights from St. Louis to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Panama City in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Panama City, Florida flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on St. Louis-Panama City, Florida flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from St. Louis-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

How far ahead should I book a flight from St. Louis to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Panama City. Price data was last updated on December 5, 2025.

The price you pay for your flight from St. Louis to Panama City, Florida may vary depending on when you book. For the best chance of a lower fare, look to book 88 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from St. Louis to Panama City, Florida?

Currently, July is the cheapest month in which you can book a flight from St. Louis to Panama City, Florida (average of $82). Flying from St. Louis to Panama City, Florida in January is currently the most expensive (average of $216). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to ECP?

Find hourly flight availability from St. Louis to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

It’s typically best to fly out from St. Louis to Panama City, Florida in the afternoon. Doing so could potentially save you 11% on the flight price compared to flying in the evening, which is usually more expensive.

What is the cheapest day to fly from St. Louis to Panama City, Florida?

Use this chart to determine the cheapest time to fly round-trip from St. Louis to Panama City. Price data was last updated on December 6, 2025.

Travelers seeking maximum savings on their St. Louis to Panama City, Florida flight should consider departing on Tuesday at noon when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated December 12, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and American Airlines from St. Louis to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,253 reviews

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
7.9
Good
4,253 reviews
Southwest
7.9
Good
4,253 reviews

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,008 reviews
Southwest
7.9
Good
4,253 reviews

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,050 reviews
Southwest
7.9
Good
4,253 reviews

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this St. Louis to Panama City, Florida flight route?

    The Lambert-St Louis to Panama City NW Florida Beaches flight path was viewed by 4 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from St. Louis to Panama City, Florida?

    Southwest and United Airlines can get you from St. Louis to Panama City, Florida in just under 5h 17m. Your travel time can differ by up to 1h 48m. The distance between St. Louis and Panama City, Florida is about 635 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from St. Louis to Panama City, Florida round-trip?

    Our cheapest airline available from St. Louis to Panama City, Florida is Delta. Our recent data shows that you can find tickets from as low as $176 on this airline. Additional options worth looking into are American Airlines and Southwest, starting at $212 and $228 round-trip. Delta is priced at 52% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from St. Louis to Panama City, Florida one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $88. However, be on the lookout for offers from American Airlines and Southwest, as they are both options that can get you from St. Louis to Panama City, Florida for a low price.

  • Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.

  • Can I find deals for business class flights from St. Louis to Panama City?

    Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama City, Florida?

    Currently, July is the cheapest month in which you can book a flight from St. Louis to Panama City, Florida (average of $82). Flying from St. Louis to Panama City, Florida in January is currently the most expensive (average of $216). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
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Top 3 airlines flying from St. Louis to Panama City

Discover the top 3 airlines that operate flights from St. Louis to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$176Average$328FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$212Average$371FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$228Average$426FlexibilityNo cancel feeOn-time63%

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