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Panama City

$86+ Cheap flights from St. Louis to Panama City, FL (STL - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/28. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ECP
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Panama City NW Florida Beaches are usually found in September or January, booked 88 days in advance, depart on a Tuesday or Monday and return on a Wednesday

Cheap flight deals from St. Louis to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$207
(American Airlines)

One-way from

$86
(Southwest)

Popular in

March

Cheapest in

September

Average price

$361

Good round-trip deal

$192 or less
From Lambert-St Louis to Panama City NW Florida Beaches
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One-way flight from Lambert-St Louis to Panama City NW Florida Beaches
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Highest demand for flights based on searches. 5% potential increase in price ($21 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Lambert-St Louis to Panama City NW Florida Beaches.
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Find flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/277:23 amSTL - ECP
1 stop6h 47mAmerican Airlines
Sat 11/12:40 pmECP - STL
1 stop4h 50mAmerican Airlines
Deal found 9/9$207
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/37:10 amSTL - ECP
1 stop6h 10mDelta
Tue 10/76:00 amECP - STL
1 stop4h 26mDelta
Deal found 9/10$227
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:00 amSTL - ECP
1 stop4h 19mDelta
Fri 11/76:00 amECP - STL
1 stop6h 35mDelta
Deal found 9/9$243
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/45:11 pmSTL - ECP
1 stop5h 52mDelta
Mon 10/66:29 pmECP - STL
1 stop5h 12mDelta
Deal found 9/9$246
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/196:00 amSTL - ECP
1 stop7h 21mAmerican Airlines
Thu 10/233:38 pmECP - STL
1 stop5h 13mAmerican Airlines
Deal found 9/9$252
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/196:00 amSTL - ECP
1 stop7h 21mAmerican Airlines
Wed 10/226:44 amECP - STL
2 stops9h 19mAmerican Airlines
Deal found 9/9$257
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/278:35 amSTL - ECP
Nonstop1h 45mSouthwest
Sat 11/14:10 pmECP - STL
1 stop4h 50mSouthwest
Deal found 9/9$269
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/43:06 pmSTL - ECP
2 stops8h 09mAmerican Airlines
Fri 11/78:21 amECP - STL
1 stop4h 54mAmerican Airlines
Deal found 9/9$273
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/21:26 pmSTL - ECP
1 stop6h 04mDelta
Mon 10/66:29 pmECP - STL
1 stop5h 12mDelta
Deal found 9/10$274
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/47:01 amSTL - ECP
1 stop7h 18mAmerican Airlines
Mon 10/62:40 pmECP - STL
2 stops9h 14mAmerican Airlines
Deal found 9/9$283

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

St. Louis

Fly to

Panama City

Route

Depart

Return

Price

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Fri 10/3

7:10 am-1:20 pm

1 stop6h 10m

Panama City NW Florida Beaches

Tue 10/7

6:00 am-10:26 am

1 stop4h 26m

$227

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 10/4

5:11 pm-11:03 pm

1 stop5h 52m

Panama City NW Florida Beaches

Mon 10/6

6:29 pm-11:41 pm

1 stop5h 12m

$246

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 10/6

11:21 am-5:24 pm

1 stop6h 03m

Panama City NW Florida Beaches

Fri 10/10

6:17 pm-11:41 pm

1 stop5h 24m

$252

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 10/27

8:35 am-10:20 am

Nonstop1h 45m

Panama City NW Florida Beaches

Sat 11/1

4:10 pm-9:00 pm

1 stop4h 50m

$269

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 10/27

6:03 am-2:10 pm

2 stops8h 07m

Panama City NW Florida Beaches

Sat 11/1

5:30 am-4:04 pm

2 stops10h 34m

$278

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 10/4

7:01 am-2:19 pm

1 stop7h 18m

Panama City NW Florida Beaches

Mon 10/6

2:40 pm-11:54 pm

2 stops9h 14m

$283

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 10/1

1:26 pm-7:30 pm

1 stop6h 04m

Panama City NW Florida Beaches

Wed 10/8

6:00 am-10:26 am

1 stop4h 26m

$297

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 10/8

6:35 am-1:00 pm

2 stops6h 25m

Panama City NW Florida Beaches

Wed 10/15

3:15 pm-5:00 pm

Nonstop1h 45m

$301

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Fri 10/3

3:36 pm-7:30 pm

1 stop3h 54m

Panama City NW Florida Beaches

Mon 10/6

6:29 pm-11:41 pm

1 stop5h 12m

$313

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 11/4

5:45 am-3:50 pm

2 stops10h 05m

Panama City NW Florida Beaches

Fri 11/7

3:20 pm-10:45 pm

2 stops7h 25m

$315

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 20 results
1
2

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

How far ahead should I book a flight from St. Louis to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Panama City. Price data was last updated on August 29, 2025.

The price you pay for your flight from St. Louis to Panama City, Florida may vary depending on when you book. For the best chance of a lower fare, look to book 88 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from St. Louis to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from St. Louis to Panama City, Florida (average of $346). Flying from St. Louis to Panama City, Florida in March is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to ECP?

Find hourly flight availability from St. Louis to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s typically best to fly out from St. Louis to Panama City, Florida in the morning. Doing so could potentially save you 8% on the flight price compared to flying in the evening, which is usually more expensive.

What is the cheapest day to fly from St. Louis to Panama City, Florida?

Use this chart to determine the cheapest time to fly round-trip from St. Louis to Panama City. Price data was last updated on September 7, 2025.

Travelers seeking maximum savings on their St. Louis to Panama City, Florida flight should consider departing on Tuesday at noon when fares are most often at their lowest. Tuesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 11, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and American Airlines from St. Louis to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,248 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,960 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Allegiant Air
7.2
Good
702 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this St. Louis to Panama City, Florida flight route?

    The Lambert-St Louis to Panama City NW Florida Beaches flight path was viewed by 4 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from St. Louis to Panama City, Florida?

    Delta, Southwest, and American Airlines can get you from St. Louis to Panama City, Florida in just under 1h 45m. Your travel time can differ by up to 6h 22m. The distance between St. Louis and Panama City, Florida is about 635 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from St. Louis to Panama City, Florida round-trip?

    Our cheapest airline available from St. Louis to Panama City, Florida is Allegiant Air. Our recent data shows that you can find tickets from as low as $102 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $186 and $212 round-trip. Allegiant Air is priced at 75% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest flights from St. Louis to Panama City, Florida?

    While on average a flight from St. Louis to Panama City, Florida is generally $238, our data shows the cheapest flight currently is $158. When looking at the most popular route, (Lambert-St Louis - Panama City NW Florida Beaches), you can expect to pay $227 for that flight.

  • Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.

  • Can I find deals for business class flights from St. Louis to Panama City?

    Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama City, Florida?

    Currently, January is the cheapest month in which you can book a flight from St. Louis to Panama City, Florida (average of $346). Flying from St. Louis to Panama City, Florida in March is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

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Top 4 airlines flying from St. Louis to Panama City

Discover the top 4 airlines that operate flights from St. Louis to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$102Average$233FlexibilityNo cancel feeOn-time88%
DeltaCheapest$186Average$404FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$212Average$391FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$232Average$435FlexibilityNo cancel feeOn-time63%

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