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Panama City

$79+ Cheap flights from St. Louis to Panama City, FL (STL - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ECP
Aug 2 — Aug 91
Sat 8/2
Sat 8/9
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Panama City NW Florida Beaches are usually found in September or August, booked 44 days in advance, depart on a Tuesday or Monday and return on a Wednesday

Cheap flight deals from St. Louis to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 28, 2025.

Round-trip from

$157
(Southwest)

One-way from

$79
(Southwest)

Popular in

November

Cheapest in

September

Average price

$404

Good round-trip deal

$228 or less
From Lambert-St Louis to Panama City NW Florida Beaches
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One-way flight from Lambert-St Louis to Panama City NW Florida Beaches
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Highest demand for flights based on searches. 3% potential increase in price ($17 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from Lambert-St Louis to Panama City NW Florida Beaches.
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Find flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2025.

This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/253:10 pmSTL - ECP
Nonstop1h 45mSouthwest
Sat 8/303:15 pmECP - STL
Nonstop1h 50mSouthwest
Deal found 7/27$157
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/196:00 amSTL - ECP
1 stop6h 48mAmerican Airlines
Sat 8/237:06 pmECP - STL
1 stop4h 49mAmerican Airlines
Deal found 7/25$167
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/199:17 amSTL - ECP
1 stop3h 51mDelta
Sat 8/236:00 amECP - STL
1 stop6h 31mDelta
Deal found 7/28$177
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/36:35 amSTL - ECP
2 stops9h 45mUnited Airlines
Tue 9/96:30 amECP - STL
2 stops9h 14mUnited Airlines
Deal found 7/27$317

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2025.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

St. Louis

Fly to

Panama City

Route

Depart

Return

Price

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 8/25

3:10 pm-4:55 pm

Nonstop1h 45m

Panama City NW Florida Beaches

Sat 8/30

3:15 pm-5:05 pm

Nonstop1h 50m

$157

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 8/19

6:00 am-12:48 pm

1 stop6h 48m

Panama City NW Florida Beaches

Sat 8/23

7:06 pm-11:55 pm

1 stop4h 49m

$167

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 8/19

9:17 am-1:08 pm

1 stop3h 51m

Panama City NW Florida Beaches

Sat 8/23

6:00 am-12:31 pm

1 stop6h 31m

$177

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 9/3

6:35 am-4:20 pm

2 stops9h 45m

Panama City NW Florida Beaches

Tue 9/9

6:30 am-3:44 pm

2 stops9h 14m

$317

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 10/26

8:05 am-9:50 am

Nonstop1h 45m

$79

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 8/25

6:02 am-12:07 pm

1 stop6h 05m

$84

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 8/24

6:49 pm-11:06 pm

1 stop4h 17m

$89

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 10/19

6:15 am-2:11 pm

1 stop7h 56m

$119

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

How far ahead should I book a flight from St. Louis to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Panama City. Price data was last updated on July 25, 2025.

The price you pay for your flight from St. Louis to Panama City, Florida may vary depending on when you book. For the best chance of a lower fare, look to book 44 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from St. Louis to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from St. Louis to Panama City, Florida (average of $346). Flying from St. Louis to Panama City, Florida in March is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to ECP?

Find hourly flight availability from St. Louis to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 28, 2025.

It’s typically best to fly out from St. Louis to Panama City, Florida in the morning. Doing so could potentially save you 4% on the flight price compared to flying in the evening, which is usually more expensive.

What is the cheapest day to fly from St. Louis to Panama City, Florida?

Use this chart to determine the cheapest time to fly round-trip from St. Louis to Panama City. Price data was last updated on July 27, 2025.

Travelers seeking maximum savings on their St. Louis to Panama City, Florida flight should consider departing on Tuesday at noon when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

What’s the top layover airport for flights from St. Louis to Panama City, Florida?

Share of 1-stop round-trip flights from St. Louis to Panama City, Florida chosen by Cheapflights users in the past 12 months, using the same layover each way.

Houston (IAH) – chosen by Cheapflights users on 50% of 1-stop itineraries from St. Louis to Panama City, Florida on Cheapflights.

What’s the cheapest layover airport for flights from St. Louis to Panama City, Florida?

Average round-trip fare for 1-stop flights from St. Louis to Panama City, Florida, chosen by Cheapflights users in the past 12 months, with the same layover each way.

Nashville (BNA) is the most affordable 1-stop option, with an average round-trip price of $466.

What’s the fastest layover option from St. Louis to Panama City, Florida?

Shortest average travel time for 1-stop one-way flights from St. Louis to Panama City, Florida, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.

Flights via Nashville (BNA) have the shortest average one-way travel time for 1-stop routes: 2h 05m.

Which airport typically offers the quickest layover for flights from St. Louis to Panama City, Florida?

Average layover duration for 1-stop one-way flights from St. Louis to Panama City, Florida, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.

Flights via Houston (IAH) offer the fastest connection on this route, with an average layover time of 0h 59m.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated July 28, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from St. Louis to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,238 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,975 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,892 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from St. Louis to Panama City?

    To fly from St. Louis to Panama City, you need to book a flight from Lambert-St Louis (STL) to NW Florida Beaches (ECP). Nonstop flights to Panama City NW Florida Beaches from Lambert-St Louis take 1h 45m on average. When it comes time to book airfare, you have a few options: there is 1 outbound flight from Lambert-St Louis to NW Florida Beaches offered by 4 different airlines.

  • How popular is this St. Louis to Panama City, Florida flight route?

    The Lambert-St Louis to Panama City NW Florida Beaches flight path was viewed by 4 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines flying from St. Louis to Panama City, Florida round-trip?

    Our cheapest airline available from St. Louis to Panama City, Florida is Southwest. Our recent data shows that you can find tickets from as low as $157 on this airline. Additional options worth looking into are American Airlines and Delta, starting at $167 and $177 round-trip. Southwest is priced at 62% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from St. Louis to Panama City, Florida one-way?

    The cheapest airline one-way is Southwest, with whom users have recently found tickets for as low as $79. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from St. Louis to Panama City, Florida for a low price.

  • What are the cheapest flights from St. Louis to Panama City, Florida?

    While on average a flight from St. Louis to Panama City, Florida is generally $313, our data shows the cheapest flight currently is $167. When looking at the most popular route, (Lambert-St Louis - Panama City NW Florida Beaches), you can expect to pay $157 for that flight.

  • Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.

  • Can I find deals for business class flights from St. Louis to Panama City?

    Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama City, Florida?

    Currently, January is the cheapest month in which you can book a flight from St. Louis to Panama City, Florida (average of $346). Flying from St. Louis to Panama City, Florida in March is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

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Top 4 airlines flying from St. Louis to Panama City

Discover the top 4 airlines that operate flights from St. Louis to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$102Average$233FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$218Average$369FlexibilityNo cancel feeOn-time71%
DeltaCheapest$219Average$404FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$263Average$444FlexibilityNo cancel feeOn-time63%

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