Panama City

$125+ Cheap flights from St. Louis to Panama City, FL (STL - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/7. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ECP
Apr 10 — Apr 171
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Find cheap flights from St. Louis to Panama City with Cheapflights

1. Tell us where you want to go

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Cheapflights Tip: The best prices from Lambert-St Louis to Panama City NW Florida Beaches are usually found in October or December, booked 81 days in advance, depart on a Tuesday or Monday and return on a Tuesday

Cheap flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.

This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:40 pm
STL
-
ECP
Nonstop1h 45m
Southwest
Tue 4/141:55 pm
ECP
-
STL
Nonstop1h 55m
Southwest
Deal found 3/10$249
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:53 pm
STL
-
ECP
1 stop4h 53m
American Airlines
Wed 5/1310:48 am
ECP
-
STL
2 stops11h 31m
American Airlines
Deal found 3/7$261
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:05 pm
STL
-
ECP
1 stop3h 46m
Delta
Wed 6/31:50 pm
ECP
-
STL
1 stop3h 56m
Delta
Deal found 3/7$263
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:15 pm
STL
-
ECP
Nonstop1h 45m
Southwest
Wed 5/131:55 pm
ECP
-
STL
Nonstop1h 55m
Southwest
Deal found 3/11$266
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:45 am
STL
-
ECP
1 stop5h 40m
Southwest
Wed 4/153:00 pm
ECP
-
STL
1 stop6h 45m
Southwest
Deal found 3/9$269
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:40 pm
STL
-
ECP
Nonstop1h 45m
Southwest
Sat 5/27:20 am
ECP
-
STL
1 stop6h 15m
Southwest
Deal found 3/9$271
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:57 pm
STL
-
ECP
1 stop4h 52m
American Airlines
Thu 3/267:19 am
ECP
-
STL
1 stop5h 24m
American Airlines
Deal found 3/7$272
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/710:00 am
STL
-
ECP
2 stops11h 59m
United Airlines
Tue 4/142:19 pm
ECP
-
STL
1 stop7h 33m
United Airlines
Deal found 3/10$274

Find flight deals from St. Louis to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$249
(Southwest)

One-way from

$125
(Southwest)

Popular in

July

Cheapest in

October

Average price

$391

Good round-trip deal

$391 or less
Provider with most accurate pricing for Lambert-St Louis-Panama City NW Florida Beaches flight deals.
Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City NW Florida Beaches flights.
From Lambert-St Louis to Panama City NW Florida Beaches
One-way flight from Lambert-St Louis to Panama City NW Florida Beaches
Highest demand for flights based on searches. 8% potential increase in price ($30 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Average for round-trip flights in March 2026
Price to beat on a round-trip flight from Lambert-St Louis to Panama City NW Florida Beaches.

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 4/7

8:25 am-4:20 pm

2 stops7h 55m

Panama City NW Florida Beaches

Tue 4/14

1:55 pm-3:50 pm

Nonstop1h 55m

$264

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 5/16

2:25 pm-6:15 pm

1 stop3h 50m

Panama City NW Florida Beaches

Sat 5/23

9:50 am-4:25 pm

1 stop6h 35m

$293

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 4/14

5:45 am-1:20 pm

2 stops7h 35m

Panama City NW Florida Beaches

Mon 4/20

4:10 pm-10:40 pm

1 stop6h 30m

$298

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 5/30

7:05 pm-10:51 pm

1 stop3h 46m

Panama City NW Florida Beaches

Wed 6/3

5:29 pm-11:59 pm

1 stop6h 30m

$301

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 5/31

7:01 pm-11:28 pm

1 stop4h 27m

Panama City NW Florida Beaches

Thu 6/4

6:44 pm-11:59 pm

1 stop5h 15m

$301

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Fri 8/28

1:30 pm-7:37 pm

1 stop6h 07m

Panama City NW Florida Beaches

Mon 8/31

7:05 pm-11:37 pm

1 stop4h 32m

$309

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 8/9

11:20 am-2:35 pm

1 stop3h 15m

Panama City NW Florida Beaches

Wed 8/12

11:30 am-8:00 pm

2 stops8h 30m

$326

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 3/26

12:20 pm-9:20 pm

1 stop9h 00m

Panama City NW Florida Beaches

Tue 3/31

10:10 am-12:10 pm

Nonstop2h 00m

$327
Quickest round-trip

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Fri 6/19

7:05 pm-10:46 pm

1 stop3h 41m

Panama City NW Florida Beaches

Mon 6/22

7:45 am-12:54 pm

1 stop5h 09m

$329

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Fri 7/17

2:10 pm-8:10 pm

1 stop6h 00m

Panama City NW Florida Beaches

Tue 7/21

7:00 am-2:45 pm

2 stops7h 45m

$335

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/8

Showing 1-10 of 22 resultsSorted by cheapest first
1
2
3

Compare providers for flights from St. Louis to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Panama City in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
CheapTicketsDealPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

How far ahead should I book a flight from St. Louis to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Panama City. Price data was last updated on March 6, 2026.

The price you pay for your flight from St. Louis to Panama City, Florida may vary depending on when you book. For the best chance of a lower fare, look to book 77 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from St. Louis to Panama City, Florida?

Currently, July is the cheapest month in which you can book a flight from St. Louis to Panama City, Florida (average of $84). Flying from St. Louis to Panama City, Florida in March is currently the most expensive (average of $129). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to ECP?

Find hourly flight availability from St. Louis to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 11, 2026.

It’s typically best to fly out from St. Louis to Panama City, Florida in the afternoon. Doing so could potentially save you 12% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated March 11, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAmerican Airlines from St. Louis to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Food

7.0

Comfort

8.0

Overall

8.0

Entertainment

7.5

Crew

8.6

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Mar 2026

KOA - HNL

pretty smooth and fast service ever, that flight is very helpful each and everyone for price and also fright for free..

Food

7.0

Comfort

8.0

Overall

8.0

Entertainment

7.5

Crew

8.6

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Mar 2026

KOA - HNL

pretty smooth and fast service ever, that flight is very helpful each and everyone for price and also fright for free..

Food

7.0

Comfort

8.0

Overall

8.0

Entertainment

7.5

Crew

8.6

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Mar 2026

KOA - HNL

pretty smooth and fast service ever, that flight is very helpful each and everyone for price and also fright for free..

Food

7.0

Comfort

8.0

Overall

8.0

Entertainment

7.5

Crew

8.6

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Mar 2026

KOA - HNL

pretty smooth and fast service ever, that flight is very helpful each and everyone for price and also fright for free..

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How popular is this St. Louis to Panama City, Florida flight route?

  • How long is the flight from St. Louis to Panama City, Florida?

    Southwest and Delta can get you from St. Louis to Panama City, Florida in just under 3h 46m. Your travel time can differ by up to 4h 09m. The distance between St. Louis and Panama City, Florida is about 635 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from St. Louis to Panama City, Florida round-trip?

    Our cheapest airline available from St. Louis to Panama City, Florida is Delta. Our recent data shows that you can find tickets from as low as $176 on this airline. Additional options worth looking into are American Airlines and Southwest, starting at $186 and $217 round-trip. Delta is priced at 50% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from St. Louis to Panama City, Florida one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $88. However, be on the lookout for offers from American Airlines and Southwest, as they are both options that can get you from St. Louis to Panama City, Florida for a low price.

  • What are the cheapest flights from St. Louis to Panama City, Florida?

    While on average a flight from St. Louis to Panama City, Florida is generally $468, our data shows the cheapest flight currently is $321. When looking at the most popular route, (Lambert-St Louis - Panama City NW Florida Beaches), you can expect to pay $249 for that flight.

  • Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.

  • Can I find deals for business class flights from St. Louis to Panama City?

    Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama City, Florida?

    Currently, July is the cheapest month in which you can book a flight from St. Louis to Panama City, Florida (average of $84). Flying from St. Louis to Panama City, Florida in March is currently the most expensive (average of $129). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
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Alternative routes for St. Louis to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from St. Louis to Panama City

Discover the top 3 airlines that operate flights from St. Louis to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$176Average$289FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$186Average$338FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$217Average$413FlexibilityNo cancel feeOn-time63%

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