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Panama City

$104+ Cheap flights from St. Louis to Panama City, FL (STL - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ECP
nov. 26 — dic. 31
mié. 11/26
mié. 12/3
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Panama City NW Florida Beaches are usually found in October or September, booked 88 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Find flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 27, 2025.

This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/57:02 pmSTL - ECP
1 stop4h 04mDelta
mar. 12/95:00 pmECP - STL
1 stop4h 57mDelta
Deal found 10/25$207
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/56:00 amSTL - ECP
1 stop6h 53mAmerican Airlines
mar. 12/98:30 amECP - STL
2 stops8h 29mAmerican Airlines
Deal found 10/25$212
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/176:00 amSTL - ECP
1 stop6h 47mDelta
dom. 12/219:22 amECP - STL
1 stop5h 08mDelta
Deal found 10/26$248
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/176:00 amSTL - ECP
2 stops10h 47mAmerican Airlines
dom. 12/217:15 amECP - STL
1 stop5h 59mAmerican Airlines
Deal found 10/26$253
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/97:02 pmSTL - ECP
1 stop4h 05mDelta
jue. 11/1311:11 amECP - STL
1 stop4h 56mDelta
Deal found 10/25$297
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/95:00 amSTL - ECP
1 stop5h 33mAmerican Airlines
jue. 11/137:15 amECP - STL
2 stops8h 57mAmerican Airlines
Deal found 10/25$302
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/301:22 pmSTL - ECP
1 stop4h 55mDelta
mar. 1/67:18 amECP - STL
1 stop3h 47mDelta
Deal found 10/26$310
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/315:00 amSTL - ECP
1 stop5h 37mAmerican Airlines
mié. 1/73:27 pmECP - STL
1 stop7h 32mAmerican Airlines
Deal found 10/26$359
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/315:00 amSTL - ECP
1 stop5h 37mAmerican Airlines
jue. 1/812:03 pmECP - STL
2 stops9h 48mAmerican Airlines
Deal found 10/26$364
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/103:06 pmSTL - ECP
2 stops8h 09mAmerican Airlines
vie. 11/148:21 amECP - STL
2 stops8h 15mAmerican Airlines
Deal found 10/26$368

Cheap flight deals from St. Louis to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated octubre 27, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$207
(Delta)

One-way from

$104
(Delta)

Popular in

March

Cheapest in

October

Average price

$296
Provider with most accurate pricing for Lambert-St Louis-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City NW Florida Beaches flights.
Search Deals
From Lambert-St Louis to Panama City NW Florida Beaches
Search Deals
One-way flight from Lambert-St Louis to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($41 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 27, 2025.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

St. Louis

Fly to

Panama City

Route

Depart

Return

Price

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

vie. 12/5

7:02 pm-11:06 pm

1 stop4h 04m

Panama City NW Florida Beaches

mar. 12/9

5:00 pm-9:57 pm

1 stop4h 57m

$207

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

vie. 12/5

9:53 am-5:18 pm

2 stops7h 25m

Panama City NW Florida Beaches

mar. 12/9

12:08 pm-9:47 pm

2 stops9h 39m

$273

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

jue. 1/8

6:00 am-12:02 pm

1 stop6h 02m

Panama City NW Florida Beaches

lun. 1/12

4:54 pm-10:00 pm

1 stop5h 06m

$289

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

jue. 1/8

7:00 am-5:33 pm

2 stops10h 33m

Panama City NW Florida Beaches

lun. 1/12

6:03 pm-11:12 pm

1 stop5h 09m

$294

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

lun. 11/10

7:02 pm-11:07 pm

1 stop4h 05m

Panama City NW Florida Beaches

vie. 11/14

7:02 am-1:00 pm

1 stop5h 58m

$297

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

dom. 11/9

7:02 pm-11:07 pm

1 stop4h 05m

Panama City NW Florida Beaches

jue. 11/13

11:11 am-4:07 pm

1 stop4h 56m

$297

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

mar. 12/30

1:22 pm-6:17 pm

1 stop4h 55m

Panama City NW Florida Beaches

mar. 1/6

7:18 am-11:05 am

1 stop3h 47m

$310

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

lun. 1/5

7:10 am-12:47 pm

1 stop5h 37m

Panama City NW Florida Beaches

mar. 1/6

7:18 am-11:05 am

1 stop3h 47m

$310

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

mar. 12/30

1:22 pm-7:56 pm

1 stop6h 34m

Panama City NW Florida Beaches

vie. 1/9

1:32 pm-5:50 pm

1 stop4h 18m

$310

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

lun. 1/5

7:10 am-12:47 pm

1 stop5h 37m

Panama City NW Florida Beaches

jue. 1/8

7:18 am-11:04 am

1 stop3h 46m

$310

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/25

Showing 1-10 of 22 results
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Compare providers for flights from St. Louis to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Panama City in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Panama City, Florida flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on St. Louis-Panama City, Florida flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from St. Louis-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

How far ahead should I book a flight from St. Louis to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Panama City. Price data was last updated on October 24, 2025.

The price you pay for your flight from St. Louis to Panama City, Florida may vary depending on when you book. For the best chance of a lower fare, look to book 88 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from St. Louis to Panama City, Florida?

Currently, December is the cheapest month in which you can book a flight from St. Louis to Panama City, Florida (average of $78). Flying from St. Louis to Panama City, Florida in February is currently the most expensive (average of $160). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to ECP?

Find hourly flight availability from St. Louis to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 27, 2025.

It’s typically best to fly out from St. Louis to Panama City, Florida in the morning. Doing so could potentially save you 9% on the flight price compared to flying in the evening, which is usually more expensive.

What is the cheapest day to fly from St. Louis to Panama City, Florida?

Use this chart to determine the cheapest time to fly round-trip from St. Louis to Panama City. Price data was last updated on October 26, 2025.

Travelers seeking maximum savings on their St. Louis to Panama City, Florida flight should consider departing on Tuesday at noon when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated octubre 27, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and American Airlines from St. Louis to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,236 reviews

Food

7.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,236 reviews
Southwest
8.0
Very good
4,236 reviews

Food

7.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,996 reviews
Southwest
8.0
Very good
4,236 reviews

Food

7.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,033 reviews
Southwest
8.0
Very good
4,236 reviews

Food

7.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this St. Louis to Panama City, Florida flight route?

    The Lambert-St Louis to Panama City NW Florida Beaches flight path was viewed by 4 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from St. Louis to Panama City, Florida?

    Delta, American Airlines, and United Airlines can get you from St. Louis to Panama City, Florida in just under 4h 04m. Your travel time can differ by up to 3h 21m. The distance between St. Louis and Panama City, Florida is about 635 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from St. Louis to Panama City, Florida round-trip?

    Our cheapest airline available from St. Louis to Panama City, Florida is Allegiant Air. Our recent data shows that you can find tickets from as low as $102 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $202 and $212 round-trip. Allegiant Air is priced at 74% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.

  • Can I find deals for business class flights from St. Louis to Panama City?

    Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama City, Florida?

    Currently, December is the cheapest month in which you can book a flight from St. Louis to Panama City, Florida (average of $78). Flying from St. Louis to Panama City, Florida in February is currently the most expensive (average of $160). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

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Top 3 airlines flying from St. Louis to Panama City

Discover the top 3 airlines that operate flights from St. Louis to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$202Average$357FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$212Average$387FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$228Average$430FlexibilityNo cancel feeOn-time63%

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