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Panama City

$132+ Cheap flights from South Carolina to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/22. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — ECP
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:35 amCHS - ECP
1 stop4h 42mDelta
Mon 12/296:00 amECP - CHS
1 stop3h 30mDelta
Deal found 12/16$427
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:09 amMYR - ECP
1 stop3h 10mDelta
Sun 1/46:00 amECP - MYR
1 stop5h 31mDelta
Deal found 12/16$431
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/202:52 pmCLT - ECP
Nonstop1h 45mAmerican Airlines
Sat 12/274:09 pmECP - CLT
Nonstop1h 51mAmerican Airlines
Deal found 12/16$433
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:41 amCLT - ECP
Nonstop1h 56mAmerican Airlines
Mon 12/297:15 amECP - CLT
Nonstop1h 56mAmerican Airlines
Deal found 12/15$437
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:15 amCLT - ECP
1 stop5h 13mDelta
Sat 12/276:00 amECP - CLT
1 stop3h 53mDelta
Deal found 12/16$453
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:35 amCHS - ECP
1 stop5h 44mDelta
Sun 1/46:00 amECP - CHS
1 stop3h 30mDelta
Deal found 12/16$464
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:45 amCLT - ECP
Nonstop1h 56mAmerican Airlines
Thu 12/2511:11 amECP - CLT
Nonstop1h 49mAmerican Airlines
Deal found 12/16$467
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:15 amCLT - ECP
1 stop5h 13mDelta
Thu 12/2511:06 amECP - CLT
1 stop3h 19mDelta
Deal found 12/16$487
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2011:24 amCLT - ECP
1 stop5h 46mUnited Airlines
Thu 12/252:10 pmECP - CLT
2 stops8h 49mUnited Airlines
Deal found 12/16$492
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/192:52 pmCLT - ECP
Nonstop1h 45mAmerican Airlines
Sun 12/214:09 pmECP - CLT
Nonstop1h 51mAmerican Airlines
Deal found 12/15$501
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2512:51 pmCHS - ECP
1 stop3h 46mAmerican Airlines
Mon 12/294:09 pmECP - CHS
1 stop6h 56mAmerican Airlines
Deal found 12/17$505
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:16 pmCAE - ECP
1 stop6h 37mAmerican Airlines
Thu 12/257:15 amECP - CAE
1 stop5h 55mAmerican Airlines
Deal found 12/16$516

Find flight deals from South Carolina to Panama City

Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(Delta)

One-way from

$132
(American Airlines)

Popular in

March

Cheapest in

September

Average price

$276
Provider with most accurate pricing for Myrtle Beach Intl-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City NW Florida Beaches flights.
Search Deals
From South Carolina to Panama City NW Florida Beaches
Search Deals
One-way flight from South Carolina to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 29% potential increase in price ($143 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

South Carolina

Fly to

Panama City

Route

Depart

Return

Price

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

Fri 1/30

2:25 pm-7:50 pm

1 stop6h 25m

Panama City NW Florida Beaches

Sun 2/1

9:24 am-4:02 pm

1 stop5h 38m

$249

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Sat 1/31

6:23 am-11:33 am

1 stop6h 10m

Panama City NW Florida Beaches

Wed 2/4

12:03 pm-4:59 pm

1 stop3h 56m

$258

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Thu 1/22

12:05 pm-5:33 pm

1 stop6h 28m

Panama City NW Florida Beaches

Mon 1/26

6:03 pm-11:15 pm

1 stop4h 12m

$263

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Fri 1/23

6:23 am-11:33 am

1 stop6h 10m

Panama City NW Florida Beaches

Mon 1/26

6:03 pm-11:15 pm

1 stop4h 12m

$263

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Fri 2/27

6:25 pm-11:52 pm

1 stop6h 27m

Panama City NW Florida Beaches

Wed 3/4

1:50 pm-8:46 pm

1 stop5h 56m

$290

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

Wed 2/25

8:45 am-9:37 am

Nonstop1h 52m

Panama City NW Florida Beaches

Sun 3/1

7:19 am-10:09 am

Nonstop1h 50m

$291

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Thu 1/15

6:00 am-9:12 am

1 stop4h 12m

Panama City NW Florida Beaches

Mon 1/19

7:20 am-1:30 pm

1 stop5h 10m

$293

CharlestonPanama City

CHS - ECP

CHSECP

Charleston

Wed 2/4

5:30 pm-10:40 pm

1 stop6h 10m

Panama City NW Florida Beaches

Mon 2/9

6:00 am-11:48 am

1 stop4h 48m

$295

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Sat 1/31

7:40 am-5:30 pm

2 stops10h 50m

Panama City NW Florida Beaches

Wed 2/4

8:00 am-5:00 pm

1 stop8h 00m

$299

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

Wed 2/25

7:55 am-1:25 pm

1 stop6h 30m

Panama City NW Florida Beaches

Sun 3/1

8:03 am-1:39 pm

1 stop4h 36m

$304

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 54 results
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Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama City

What is the cheapest month to book a flight from South Carolina to Panama City, Florida?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Panama City, Florida (average of $124). Flying from South Carolina to Panama City, Florida in November is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to ECP?

Find hourly flight availability from South Carolina to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

One of the essential ways to save on airfare from South Carolina to Panama City, Florida is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 14% on airfare.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from South Carolina?

    Panama City NW Florida Beaches (ECP) is the airport you will fly into if you book a flight from South Carolina to Panama City. It is only a 16.0 mi journey from NW Florida Beaches (ECP) to Panama City’s city center.

  • How long is the flight from South Carolina to Panama City, Florida?

    A quick flight from South Carolina to Panama City, Florida can take about 6h 10m. Delta provides one of the quickest options available for as low as $258. The distance between South Carolina and Panama City, Florida is about 463 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from South Carolina to Panama City, Florida?

    While some choose either Charleston - Panama City NW Florida Beaches or Myrtle Beach Intl - Panama City NW Florida Beaches, Charlotte Douglas - Panama City NW Florida Beaches is the most popular route from South Carolina to Panama City, Florida.

  • Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.

  • Can I find deals for business class flights from South Carolina to Panama City?

    Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama City, Florida?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Panama City, Florida (average of $124). Flying from South Carolina to Panama City, Florida in November is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

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Alternative routes for South Carolina to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Panama City

Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$207Average$382FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$216Average$361FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$283Average$447FlexibilityNo cancel feeOn-time63%

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