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Panama City

$130+ Cheap flights from South Carolina to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — ECP
nov. 29 — dic. 61
sáb. 11/29
sáb. 12/6
1 adult, Economy
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Find flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 30, 2025.

This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/2911:58 amCLT - ECP
Nonstop1h 59mAmerican Airlines
jue. 12/47:15 amECP - CLT
Nonstop1h 52mAmerican Airlines
Deal found 10/29$271
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/1410:19 pmCLT - ECP
Nonstop1h 56mAmerican Airlines
mié. 11/198:21 amECP - CLT
Nonstop1h 50mAmerican Airlines
Deal found 10/28$274
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/147:13 pmCLT - ECP
1 stop4h 54mDelta
mié. 11/199:23 amECP - CLT
1 stop6h 01mDelta
Deal found 10/28$304
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/1310:52 pmCLT - ECP
Nonstop1h 57mAmerican Airlines
lun. 11/178:21 amECP - CLT
Nonstop1h 50mAmerican Airlines
Deal found 10/29$319
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/2610:30 amCLT - ECP
2 stops8h 25mSouthwest
mié. 12/34:25 pmECP - CLT
1 stop3h 45mSouthwest
Deal found 10/29$324
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/145:30 amCLT - ECP
1 stop4h 05mDelta
dom. 11/166:00 amECP - CLT
1 stop3h 55mDelta
Deal found 10/29$339
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/266:00 amCLT - ECP
1 stop3h 37mDelta
mar. 12/306:00 amECP - CLT
1 stop3h 53mDelta
Deal found 10/30$353
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/259:40 amCLT - ECP
Nonstop1h 53mAmerican Airlines
mar. 12/28:21 amECP - CLT
Nonstop1h 50mAmerican Airlines
Deal found 10/28$363
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/117:00 amCLT - ECP
1 stop8h 40mSouthwest
sáb. 11/157:50 amECP - CLT
1 stop3h 45mSouthwest
Deal found 10/29$364
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/1411:33 amAGS - ECP
1 stop4h 58mDelta
mar. 11/181:32 pmECP - AGS
1 stop6h 09mDelta
Deal found 10/30$407
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/143:47 pmCHS - ECP
1 stop3h 08mDelta
mar. 11/181:32 pmECP - CHS
1 stop4h 38mDelta
Deal found 10/30$431
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/136:00 amMYR - ECP
1 stop3h 35mDelta
lun. 11/174:26 pmECP - MYR
1 stop6h 18mDelta
Deal found 10/29$431

Cheap flight deals from South Carolina to Panama City

Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated octubre 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$254
(Southwest)

One-way from

$130
(Southwest)

Popular in

March

Cheapest in

September
Provider with most accurate pricing for Myrtle Beach Intl-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City NW Florida Beaches flights.
Search Deals
From South Carolina to Panama City NW Florida Beaches
Search Deals
One-way flight from South Carolina to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 31% potential increase in price ($151 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($22 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

South Carolina

Fly to

Panama City

Route

Depart

Return

Price

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

vie. 1/16

5:25 am-9:14 am

1 stop4h 49m

Panama City NW Florida Beaches

lun. 1/19

7:18 am-1:40 pm

1 stop5h 22m

$284

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

vie. 1/16

6:59 pm-10:55 pm

1 stop4h 56m

Panama City NW Florida Beaches

dom. 1/18

1:32 pm-6:12 pm

1 stop3h 40m

$304

CharlestonPanama City

CHS - ECP

CHSECP

Charleston

mar. 3/31

7:45 am-12:40 pm

1 stop5h 55m

Panama City NW Florida Beaches

mié. 4/1

6:00 am-11:25 am

1 stop4h 25m

$317

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

mar. 3/17

2:15 pm-7:38 pm

1 stop6h 23m

Panama City NW Florida Beaches

mié. 3/18

7:45 am-1:29 pm

1 stop4h 44m

$317

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

mié. 11/26

10:30 am-5:55 pm

2 stops8h 25m

Panama City NW Florida Beaches

mié. 12/3

4:25 pm-9:10 pm

1 stop3h 45m

$324

ColumbiaPanama City

CAE - ECP

CAEECP

Columbia Metropolitan

sáb. 4/25

10:10 am-12:38 pm

1 stop3h 28m

Panama City NW Florida Beaches

sáb. 5/2

7:45 am-2:12 pm

1 stop5h 27m

$327

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

vie. 2/13

7:55 pm-10:42 pm

1 stop3h 47m

Panama City NW Florida Beaches

lun. 2/16

6:00 am-11:00 am

1 stop4h 00m

$327

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

vie. 11/14

5:30 am-8:35 am

1 stop4h 05m

Panama City NW Florida Beaches

dom. 11/16

6:00 am-10:55 am

1 stop3h 55m

$339

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

vie. 11/14

7:13 pm-11:07 pm

1 stop4h 54m

Panama City NW Florida Beaches

mié. 11/19

1:32 pm-8:14 pm

1 stop5h 42m

$339

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

vie. 12/26

6:00 am-8:37 am

1 stop3h 37m

Panama City NW Florida Beaches

mar. 12/30

6:00 am-10:53 am

1 stop3h 53m

$353

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 43 results
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Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama City

What is the cheapest month to book a flight from South Carolina to Panama City, Florida?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Panama City, Florida (average of $124). Flying from South Carolina to Panama City, Florida in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to ECP?

Find hourly flight availability from South Carolina to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 30, 2025.

One of the essential ways to save on airfare from South Carolina to Panama City, Florida is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 14% on airfare.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from South Carolina?

    Panama City NW Florida Beaches (ECP) is the airport you will fly into if you book a flight from South Carolina to Panama City. It is only a 16.0 mi journey from NW Florida Beaches (ECP) to Panama City’s city center.

  • How long is the flight from South Carolina to Panama City, Florida?

    A quick flight from South Carolina to Panama City, Florida can take about 4h 49m. Delta provides one of the quickest options available for as low as $284. The distance between South Carolina and Panama City, Florida is about 438 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Panama City, Florida one-way?

    $130 is the cheapest one-way deal found within the past few days, from Southwest. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $164 and $357, respectively.

  • What are the most popular routes from South Carolina to Panama City, Florida?

    While some choose either Charleston - Panama City NW Florida Beaches or Columbia Metropolitan - Panama City NW Florida Beaches, Charlotte Douglas - Panama City NW Florida Beaches is the most popular route from South Carolina to Panama City, Florida.

  • Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.

  • Can I find deals for business class flights from South Carolina to Panama City?

    Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama City, Florida?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Panama City, Florida (average of $124). Flying from South Carolina to Panama City, Florida in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

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Alternative routes for South Carolina to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Panama City

Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$207Average$387FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$216Average$361FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$283Average$412FlexibilityNo cancel feeOn-time63%

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