$155+ Cheap flights from South Carolina to Panama City, FL (ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — ECP
Mar 6 — Mar 131
1 adult, Economy
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Find cheap flights from South Carolina to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Panama City
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Cheapest flights from South Carolina to Panama CityExplore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2811:00 pm
CLT
- ECP
Nonstop1h 49m
American Airlines
Mon 3/27:19 am
ECP
- CLT
Nonstop1h 52m
American Airlines
Deal found 2/2![American Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1110:55 am
CLT
- ECP
2 stops9h 05m
Southwest
Sat 4/187:20 am
ECP
- CLT
1 stop6h 50m
Southwest
Deal found 2/1![Southwest logo]()
$280
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/39:30 pm
CLT
- ECP
Nonstop1h 47m
American Airlines
Tue 3/108:20 am
ECP
- CLT
Nonstop1h 49m
American Airlines
Deal found 2/1![American Airlines logo]()
$281
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/257:55 am
CLT
- ECP
1 stop4h 30m
Delta
Sat 2/289:26 am
ECP
- CLT
1 stop5h 38m
Delta
Deal found 2/3![Delta logo]()
$289
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/211:00 pm
CLT
- ECP
Nonstop1h 49m
American Airlines
Sat 3/74:39 pm
ECP
- CLT
Nonstop1h 48m
American Airlines
Deal found 2/1![American Airlines logo]()
$291
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:26 pm
CLT
- ECP
1 stop5h 26m
Delta
Tue 3/106:00 am
ECP
- CLT
1 stop3h 48m
Delta
Deal found 2/1![Delta logo]()
$301
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:45 am
GSP
- ECP
1 stop3h 45m
Southwest
Sat 4/117:55 am
ECP
- GSP
2 stops7h 40m
Southwest
Deal found 2/3![Southwest logo]()
$310
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/29:54 am
CLT
- ECP
1 stop4h 26m
Delta
Sat 3/79:26 am
ECP
- CLT
1 stop3h 13m
Delta
Deal found 2/1![Delta logo]()
$311
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/711:00 pm
CLT
- ECP
Nonstop1h 49m
American Airlines
Wed 3/114:34 pm
ECP
- CLT
Nonstop1h 48m
American Airlines
Deal found 2/3![American Airlines logo]()
$313
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:45 am
GSP
- ECP
1 stop3h 45m
Southwest
Fri 4/106:40 am
ECP
- GSP
2 stops10h 10m
Southwest
Deal found 2/2![Southwest logo]()
$314
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/710:30 am
CHS
- ECP
1 stop5h 46m
Delta
Tue 7/1411:15 am
ECP
- CHS
1 stop4h 36m
Delta
Deal found 2/3![Delta logo]()
$315
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/123:42 pm
GSP
- ECP
1 stop3h 09m
Delta
Wed 8/199:23 am
ECP
- GSP
1 stop2h 45m
Delta
Deal found 2/2![Delta logo]()
$315
Best flights from South Carolina to Panama CityDiscover carefully curated flight deals from South Carolina to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
Discover carefully curated flight deals from South Carolina to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:05 am
CLT
- ECP
1 stop11h 45m
Southwest
Sat 4/187:20 am
ECP
- CLT
1 stop6h 50m
Southwest
Deal found 2/1![Southwest logo]()
$280
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:27 am
CHS
- ECP
1 stop4h 13m
Delta
Wed 4/87:05 am
ECP
- CHS
1 stop3h 19m
Delta
Deal found 2/1![Delta logo]()
$315
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:06 am
CHS
- ECP
2 stops12h 11m
American Airlines
Tue 3/102:00 pm
ECP
- CHS
1 stop6h 22m
American Airlines
Deal found 2/1![American Airlines logo]()
$320
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:45 am
GSP
- ECP
1 stop3h 45m
Southwest
Sat 4/117:55 am
ECP
- GSP
2 stops7h 40m
Southwest
Deal found 2/3![Southwest logo]()
$310
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/36:30 am
CHS
- ECP
1 stop3h 11m
Delta
Tue 3/106:00 am
ECP
- CHS
1 stop4h 24m
Delta
Deal found 2/1![Delta logo]()
$315
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/711:00 pm
CLT
- ECP
Nonstop1h 49m
American Airlines
Sat 3/147:19 am
ECP
- CLT
Nonstop1h 52m
American Airlines
Deal found 2/3![American Airlines logo]()
$336
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:45 am
GSP
- ECP
1 stop3h 45m
Southwest
Fri 4/106:40 am
ECP
- GSP
2 stops10h 10m
Southwest
Deal found 2/2![Southwest logo]()
$314
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
MYR
- ECP
1 stop3h 41m
Delta
Mon 3/96:43 pm
ECP
- MYR
1 stop4h 21m
Delta
Deal found 2/2![Delta logo]()
$321
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/88:20 am
GSP
- ECP
2 stops13h 05m
Southwest
Sat 4/117:55 am
ECP
- GSP
2 stops7h 40m
Southwest
Deal found 2/3![Southwest logo]()
$315
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:38 am
CAE
- ECP
1 stop3h 57m
Delta
Sat 4/187:00 am
ECP
- CAE
1 stop5h 14m
Delta
Deal found 2/2![Delta logo]()
$324
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/612:25 pm
GSP
- ECP
1 stop9h 10m
Southwest
Thu 4/95:25 pm
ECP
- GSP
1 stop3h 50m
Southwest
Deal found 2/2![Southwest logo]()
$323
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/75:25 am
CLT
- ECP
1 stop4h 16m
Delta
Wed 3/118:25 am
ECP
- CLT
1 stop4h 16m
Delta
Deal found 2/3![Delta logo]()
$333
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/176:54 am
MYR
- ECP
1 stop3h 42m
American Airlines
Fri 2/207:19 am
ECP
- MYR
1 stop3h 54m
American Airlines
Deal found 2/3![American Airlines logo]()
$431
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/103:45 pm
MYR
- ECP
1 stop4h 50m
Southwest
Tue 4/147:55 am
ECP
- MYR
2 stops11h 40m
Southwest
Deal found 2/2![Southwest logo]()
$324
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/22:59 pm
AGS
- ECP
1 stop5h 31m
Delta
Mon 3/94:23 pm
ECP
- AGS
1 stop3h 32m
Delta
Deal found 2/2![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/112:50 pm
CLT
- ECP
1 stop8h 10m
Southwest
Sat 4/119:55 am
ECP
- CLT
2 stops10h 20m
Southwest
Deal found 2/3![Southwest logo]()
$325
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/63:07 pm
CHS
- ECP
1 stop5h 23m
Delta
Mon 3/97:05 am
ECP
- CHS
1 stop3h 19m
Delta
Deal found 2/1![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:50 am
CLT
- ECP
2 stops13h 55m
Southwest
Sat 3/76:00 pm
ECP
- CLT
1 stop3h 50m
Southwest
Deal found 2/1![Southwest logo]()
$329
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/78:11 pm
CAE
- ECP
1 stop4h 38m
American Airlines
Sat 3/147:19 am
ECP
- CAE
1 stop5h 55m
American Airlines
Deal found 2/3![American Airlines logo]()
$517
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/174:36 pm
CHS
- ECP
1 stop4h 00m
Delta
Mon 4/205:49 am
ECP
- CHS
1 stop3h 20m
Delta
Deal found 2/2![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/112:50 pm
CHS
- ECP
1 stop8h 10m
Southwest
Wed 4/810:10 am
ECP
- CHS
2 stops8h 50m
Southwest
Deal found 2/1![Southwest logo]()
$339
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/75:27 am
CHS
- ECP
1 stop4h 14m
Delta
Mon 3/96:00 am
ECP
- CHS
1 stop6h 21m
Delta
Deal found 2/1![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/1412:55 pm
CLT
- ECP
1 stop8h 30m
Southwest
Wed 3/187:30 am
ECP
- CLT
2 stops9h 50m
Southwest
Deal found 2/1![Southwest logo]()
$340
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/38:25 am
CLT
- ECP
2 stops10h 45m
Southwest
Tue 3/107:30 am
ECP
- CLT
2 stops9h 50m
Southwest
Deal found 2/1![Southwest logo]()
$343
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:35 pm
CHS
- ECP
1 stop4h 01m
Delta
Fri 4/246:46 pm
ECP
- CHS
1 stop4h 36m
Delta
Deal found 2/1![Delta logo]()
$395
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:15 am
CLT
- ECP
2 stops11h 00m
Southwest
Thu 5/711:30 am
ECP
- CLT
2 stops7h 15m
Southwest
Deal found 2/1![Southwest logo]()
$347
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:40 am
CAE
- ECP
1 stop3h 01m
Delta
Sun 2/226:06 pm
ECP
- CAE
1 stop4h 41m
Delta
Deal found 2/2![Delta logo]()
$403
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1012:45 pm
CLT
- ECP
1 stop9h 55m
Southwest
Tue 4/147:15 am
ECP
- CLT
1 stop4h 40m
Southwest
Deal found 2/2![Southwest logo]()
$347
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:00 am
CAE
- ECP
2 stops11h 03m
American Airlines
Sat 4/187:21 am
ECP
- CAE
1 stop3h 59m
American Airlines
Deal found 2/2![American Airlines logo]()
$751
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/175:35 am
AGS
- ECP
1 stop4h 06m
Delta
Sat 2/216:00 am
ECP
- AGS
1 stop3h 48m
Delta
Deal found 2/2![Delta logo]()
$407
Last-minute flights from South Carolina to Panama CityDiscover last-minute flight deals from South Carolina to Panama City. Data last updated February 4, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Panama City. Data last updated February 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2311:00 pm
CLT
- ECP
Nonstop1h 49m
American Airlines
Fri 3/64:34 pm
ECP
- CLT
Nonstop1h 48m
American Airlines
Deal found 2/2![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/257:55 am
CLT
- ECP
1 stop4h 30m
Delta
Sat 2/289:26 am
ECP
- CLT
1 stop5h 38m
Delta
Deal found 2/3![Delta logo]()
$289
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:25 am
CLT
- ECP
1 stop3h 16m
Delta
Sun 3/18:03 am
ECP
- CLT
1 stop4h 36m
Delta
Deal found 2/2![Delta logo]()
$324
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2811:00 pm
CLT
- ECP
Nonstop1h 49m
American Airlines
Mon 3/27:19 am
ECP
- CLT
Nonstop1h 52m
American Airlines
Deal found 2/2![American Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/211:00 pm
CLT
- ECP
Nonstop1h 49m
American Airlines
Sat 3/74:39 pm
ECP
- CLT
Nonstop1h 48m
American Airlines
Deal found 2/1![American Airlines logo]()
$291
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/29:54 am
CLT
- ECP
1 stop4h 26m
Delta
Sat 3/79:26 am
ECP
- CLT
1 stop3h 13m
Delta
Deal found 2/1![Delta logo]()
$311
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/39:30 pm
CLT
- ECP
Nonstop1h 47m
American Airlines
Tue 3/108:20 am
ECP
- CLT
Nonstop1h 49m
American Airlines
Deal found 2/1![American Airlines logo]()
$281
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:26 pm
CLT
- ECP
1 stop5h 26m
Delta
Tue 3/106:00 am
ECP
- CLT
1 stop3h 48m
Delta
Deal found 2/1![Delta logo]()
$301
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/36:30 am
CHS
- ECP
1 stop3h 11m
Delta
Tue 3/106:00 am
ECP
- CHS
1 stop4h 24m
Delta
Deal found 2/1![Delta logo]()
$315
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:06 am
CHS
- ECP
2 stops12h 11m
American Airlines
Tue 3/102:00 pm
ECP
- CHS
1 stop6h 22m
American Airlines
Deal found 2/1![American Airlines logo]()
$320
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
MYR
- ECP
1 stop3h 41m
Delta
Mon 3/96:43 pm
ECP
- MYR
1 stop4h 21m
Delta
Deal found 2/2![Delta logo]()
$321
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/711:00 pm
CLT
- ECP
Nonstop1h 49m
American Airlines
Wed 3/114:34 pm
ECP
- CLT
Nonstop1h 48m
American Airlines
Deal found 2/3![American Airlines logo]()
$313
One-way flights from South Carolina to Panama CitySearch for one-way flight options from South Carolina to Panama City. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
Search for one-way flight options from South Carolina to Panama City. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/112:50 pm
CLT
- ECP
1 stop8h 10m
Southwest
Deal found 2/1![Southwest logo]()
$155
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
MYR
- ECP
1 stop3h 41m
Delta
Deal found 2/2![Delta logo]()
$158
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:00 am
MYR
- ECP
1 stop3h 41m
Delta
Deal found 2/2![Delta logo]()
$164
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:15 pm
CLT
- ECP
2 stops7h 45m
Southwest
Deal found 2/2![Southwest logo]()
$171
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/86:00 am
MYR
- ECP
1 stop3h 40m
Delta
Deal found 2/2![Delta logo]()
$178
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/36:00 am
MYR
- ECP
1 stop3h 41m
Delta
Deal found 2/2![Delta logo]()
$184
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/96:10 am
CLT
- ECP
1 stop4h 05m
Southwest
Deal found 2/2![Southwest logo]()
$188
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/213:20 pm
CLT
- ECP
1 stop6h 40m
Southwest
Deal found 2/2![Southwest logo]()
$190
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:50 am
CLT
- ECP
2 stops13h 55m
Southwest
Deal found 2/3![Southwest logo]()
$191
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:50 am
CLT
- ECP
2 stops8h 30m
Southwest
Deal found 2/2![Southwest logo]()
$193
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/312:45 pm
CLT
- ECP
1 stop8h 50m
Southwest
Deal found 2/2![Southwest logo]()
$203
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:10 am
CLT
- ECP
2 stops12h 10m
Southwest
Deal found 2/3![Southwest logo]()
$209
Find flight deals from South Carolina to Panama City
Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated February 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $267 (American Airlines) |
One-way from | $155 (Southwest) |
Popular in | March |
Cheapest in | September |
Average price | $401 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.
Fly from
South Carolina
Fly to
Panama City
Route
Depart
Return
Price
CharlottePanama City
CLT - ECP
CLTECP
Charlotte Douglas
Sat 4/11
7:05 am-5:50 pm
1 stop11h 45m
Panama City NW Florida Beaches
Sat 4/18
7:20 am-3:10 pm
1 stop6h 50m
$280
GreenvillePanama City
GSP - ECP
GSPECP
Greenville
Tue 4/7
6:45 am-9:30 am
1 stop3h 45m
Panama City NW Florida Beaches
Sat 4/11
7:55 am-4:35 pm
2 stops7h 40m
$310
GreenvillePanama City
GSP - ECP
GSPECP
Greenville
Tue 4/7
6:45 am-9:30 am
1 stop3h 45m
Panama City NW Florida Beaches
Fri 4/10
6:40 am-5:50 pm
2 stops10h 10m
$314
CharlestonPanama City
CHS - ECP
CHSECP
Charleston
Wed 4/1
5:27 am-8:40 am
1 stop4h 13m
Panama City NW Florida Beaches
Wed 4/8
7:05 am-11:24 am
1 stop3h 19m
$315
CharlestonPanama City
CHS - ECP
CHSECP
Charleston
Tue 3/3
6:30 am-8:41 am
1 stop3h 11m
Panama City NW Florida Beaches
Tue 3/10
6:00 am-11:24 am
1 stop4h 24m
$315
GreenvillePanama City
GSP - ECP
GSPECP
Greenville
Wed 4/8
8:20 am-8:25 pm
2 stops13h 05m
Panama City NW Florida Beaches
Sat 4/11
7:55 am-4:35 pm
2 stops7h 40m
$315
CharlestonPanama City
CHS - ECP
CHSECP
Charleston
Tue 3/3
11:06 am-10:17 pm
2 stops12h 11m
Panama City NW Florida Beaches
Tue 3/10
2:00 pm-9:22 pm
1 stop6h 22m
$320
Myrtle BeachPanama City
MYR - ECP
MYRECP
Myrtle Beach Intl
Wed 3/4
6:00 am-8:41 am
1 stop3h 41m
Panama City NW Florida Beaches
Mon 3/9
6:43 pm-12:04 am
1 stop4h 21m
$321
GreenvillePanama City
GSP - ECP
GSPECP
Greenville
Mon 4/6
12:25 pm-8:35 pm
1 stop9h 10m
Panama City NW Florida Beaches
Thu 4/9
5:25 pm-10:15 pm
1 stop3h 50m
$323
ColumbiaPanama City
CAE - ECP
CAEECP
Columbia Metropolitan
Wed 4/15
5:38 am-8:35 am
1 stop3h 57m
Panama City NW Florida Beaches
Sat 4/18
7:00 am-1:14 pm
1 stop5h 14m
$324
Showing 1-10 of 57 results
Best time to book a flight from South Carolina to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
CLT-ECP
CHS-ECP
MYR-ECP
AGS-ECP
CAE-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Panama City
USSC-ECP
CLT-ECP
CHS-ECP
MYR-ECP
AGS-ECP
What is the cheapest month to book a flight from South Carolina to Panama City, Florida?
Currently, September is the cheapest month in which you can book a flight from South Carolina to Panama City, Florida (average of $124). Flying from South Carolina to Panama City, Florida in November is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to ECP?
Find hourly flight availability from South Carolina to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 4, 2026.
One of the essential ways to save on airfare from South Carolina to Panama City, Florida is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 27% on airfare.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for South Carolina to Panama City
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Panama City by cabin class
Find flights from South Carolina to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Panama City flights
Browse other South Carolina and Panama City flight options. Last updated on February 4, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Panama City flights
Consider these flights traveling from South Carolina to Panama City.
Top 3 airlines flying from South Carolina to Panama City
Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$207 | Average$386 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$216 | Average$321 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$283 | Average$447 | FlexibilityNo cancel fee | On-time63% |