$279+ Cheap flights from Greenville to Panama City, FL (GSP - ECP)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/12. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — ECP
Nov 30 — Dec 71
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Greenville to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to Panama City
Cheapest
Best
Last-minute
Cheapest flights from Greenville to Panama CityExplore the most affordable flight options available from Greenville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 31, 2026.
Explore the most affordable flight options available from Greenville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 31, 2026.
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/125:40 am -
1 stop3h 58m
Wed 12/165:16 pm -
1 stop4h 06m
Deal found 10/27![Delta logo]()
$279
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1110:27 am -
1 stop5h 34m
Wed 12/161:38 pm -
1 stop3h 42m
Deal found 10/27![Delta logo]()
$299
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/125:40 am -
1 stop3h 58m
Fri 12/187:04 am -
1 stop3h 09m
Deal found 10/27![Delta logo]()
$305
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:05 am -
1 stop3h 25m
Sun 12/1311:25 am -
1 stop7h 45m
Deal found 10/26![Southwest logo]()
$308
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/135:40 am -
1 stop3h 58m
Wed 12/161:38 pm -
1 stop3h 42m
Deal found 10/27![Delta logo]()
$325
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:37 pm -
1 stop4h 32m
Sat 11/217:25 am -
1 stop5h 37m
Deal found 10/30![American Airlines logo]()
$337
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:35 pm -
1 stop4h 12m
Wed 12/25:53 pm -
1 stop4h 08m
Deal found 10/28![American Airlines logo]()
$338
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:05 am -
2 stops9h 30m
Sat 11/216:25 pm -
1 stop3h 40m
Deal found 10/30![Southwest logo]()
$342
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/127:00 am -
1 stop4h 34m
Sun 12/206:00 am -
1 stop4h 59m
Deal found 10/27![Delta logo]()
$346
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/85:00 pm -
1 stop5h 38m
Wed 12/91:30 pm -
1 stop7h 29m
Deal found 10/28![United Airlines logo]()
$347
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/135:40 am -
1 stop3h 58m
Fri 12/189:23 am -
1 stop2h 59m
Deal found 10/27![Delta logo]()
$351
Best flights from Greenville to Panama CityDiscover carefully curated flight deals from Greenville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 31, 2026.
Discover carefully curated flight deals from Greenville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 31, 2026.
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/125:40 am -
1 stop3h 58m
Wed 12/165:16 pm -
1 stop4h 06m
Deal found 10/27![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:05 am -
2 stops9h 30m
Sun 12/1311:25 am -
1 stop10h 35m
Deal found 10/26![Southwest logo]()
$314
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/85:00 pm -
1 stop5h 38m
Wed 12/91:30 pm -
1 stop7h 29m
Deal found 10/28![United Airlines logo]()
$347
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/125:40 am -
1 stop3h 58m
Fri 12/187:04 am -
1 stop3h 09m
Deal found 10/27![Delta logo]()
$305
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/168:06 am -
1 stop5h 43m
Fri 12/186:00 am -
1 stop4h 13m
Deal found 10/27![Delta logo]()
$305
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:05 am -
2 stops9h 30m
Sat 11/216:25 pm -
1 stop3h 40m
Deal found 10/30![Southwest logo]()
$342
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/145:40 am -
1 stop5h 54m
Fri 12/189:23 am -
1 stop2h 59m
Deal found 10/27![Delta logo]()
$305
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:30 am -
1 stop7h 47m
Wed 12/91:30 pm -
1 stop7h 29m
Deal found 10/30![United Airlines logo]()
$385
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:40 am -
1 stop3h 55m
Sun 12/1310:10 am -
2 stops9h 00m
Deal found 10/30![Southwest logo]()
$396
Last-minute flights from Greenville to Panama CityDiscover last-minute flight deals from Greenville to Panama City. Data last updated October 31, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to Panama City. Data last updated October 31, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:40 am -
1 stop4h 05m
Sun 11/156:00 am -
1 stop4h 07m
Deal found 10/27![Delta logo]()
$440
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:42 pm -
1 stop4h 42m
Sun 11/157:15 am -
1 stop2h 52m
Deal found 10/29![Delta logo]()
$461
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:52 pm -
1 stop4h 00m
Wed 11/1812:00 pm -
1 stop5h 55m
Deal found 10/30![American Airlines logo]()
$379
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:05 am -
1 stop3h 25m
Wed 11/1810:05 am -
2 stops9h 45m
Deal found 10/30![Southwest logo]()
$384
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:37 pm -
1 stop4h 32m
Sat 11/217:25 am -
1 stop5h 37m
Deal found 10/30![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:05 am -
2 stops9h 30m
Sat 11/216:25 pm -
1 stop3h 40m
Deal found 10/30![Southwest logo]()
$342
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:35 pm -
1 stop4h 12m
Wed 12/25:53 pm -
1 stop4h 08m
Deal found 10/28![American Airlines logo]()
$338
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:45 pm -
2 stops10h 55m
Wed 12/27:55 am -
1 stop5h 15m
Deal found 10/28![Southwest logo]()
$368
Find flight deals from Greenville to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 31, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $279 (Delta) |
Popular in | April |
Cheapest in | January |
Average price | $463 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 31, 2026.
Use the filters below to find and compare flights from Greenville to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvillePanama City
GSP Greenville - ECP Panama City NW Florida Beaches
GSPECP
Greenville
Sat 12/12
5:40 am-8:38 am
1 stop3h 58m
Panama City NW Florida Beaches
Wed 12/16
5:16 pm-10:22 pm
1 stop4h 06m
$279
Quickest round-trip
GreenvillePanama City
GSP Greenville - ECP Panama City NW Florida Beaches
GSPECP
Greenville
Sat 12/12
5:40 am-8:38 am
1 stop3h 58m
Panama City NW Florida Beaches
Fri 12/18
7:04 am-11:13 am
1 stop3h 09m
$305
GreenvillePanama City
GSP Greenville - ECP Panama City NW Florida Beaches
GSPECP
Greenville
Wed 12/16
8:06 am-12:49 pm
1 stop5h 43m
Panama City NW Florida Beaches
Fri 12/18
6:00 am-11:13 am
1 stop4h 13m
$305
GreenvillePanama City
GSP Greenville - ECP Panama City NW Florida Beaches
GSPECP
Greenville
Mon 12/14
5:40 am-10:34 am
1 stop5h 54m
Panama City NW Florida Beaches
Fri 12/18
9:23 am-1:22 pm
1 stop2h 59m
$305
GreenvillePanama City
GSP Greenville - ECP Panama City NW Florida Beaches
GSPECP
Greenville
Thu 12/10
7:05 am-3:35 pm
2 stops9h 30m
Panama City NW Florida Beaches
Sun 12/13
11:25 am-11:00 pm
1 stop10h 35m
$314
GreenvillePanama City
GSP Greenville - ECP Panama City NW Florida Beaches
GSPECP
Greenville
Wed 11/18
7:05 am-3:35 pm
2 stops9h 30m
Panama City NW Florida Beaches
Sat 11/21
6:25 pm-11:05 pm
1 stop3h 40m
$342
GreenvillePanama City
GSP Greenville - ECP Panama City NW Florida Beaches
GSPECP
Greenville
Tue 12/8
5:00 pm-9:38 pm
1 stop5h 38m
Panama City NW Florida Beaches
Wed 12/9
1:30 pm-9:59 pm
1 stop7h 29m
$347
GreenvillePanama City
GSP Greenville - ECP Panama City NW Florida Beaches
GSPECP
Greenville
Sat 12/5
6:30 am-1:17 pm
1 stop7h 47m
Panama City NW Florida Beaches
Wed 12/9
1:30 pm-9:59 pm
1 stop7h 29m
$385
GreenvillePanama City
GSP Greenville - ECP Panama City NW Florida Beaches
GSPECP
Greenville
Fri 12/11
6:40 am-9:35 am
1 stop3h 55m
Panama City NW Florida Beaches
Sun 12/13
10:10 am-8:10 pm
2 stops9h 00m
$396
Sorted by cheapest first
Compare providers for flights from Greenville to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Panama City in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Greenville with our price prediction graph.
GSP-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated October 31, 2026.
Peruse reviews from past customers who have flown with Delta from Greenville to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Comfort
7.8
Overall
7.8
Boarding
8.1
Food
7.2
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Crew
8.5
Comfort
7.8
Overall
7.8
Boarding
8.1
Food
7.2
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Related info for your journey
Find useful and relevant information for your journey from Greenville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Greenville
Panama City flight routes
Popular flights
Alternative routes for Greenville to Panama City
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Greenville to Panama City by cabin class
Find flights from Greenville to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Greenville and Panama City flights
Browse other Greenville and Panama City flight options. Last updated on October 31, 2026.
Other flights from Greenville
Browse through other flights departing from Greenville. Flights are based on user searches made on Cheapflights and were last updated on October 31, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 31, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Greenville to Panama City
Discover the top airline that operate flights from Greenville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 31, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$272 | Average$395 | FlexibilityNo cancel fee | On-timeN/A |