What are the cheapest airlines flying from Panama City, Florida to Greenville round-trip?

Currently priced at $307, American Airlines will fly you from Panama City, Florida to Greenville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Southwest and Delta - these airlines can fly you to your destination from $328 and $428, respectively. You may be able to fly from Panama City, Florida to Greenville for 31% less than the average price by searching for these airlines.

What is the cheapest day to fly from Panama City, Florida to Greenville?

Travelers seeking maximum savings on their Panama City, Florida to Greenville flight should consider departing on Wednesday mornings when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Greenville ranges from 3.6 - 5.1 inches per month. March is typically the wettest month, when rainfall can reach 5.1 in. November is typically the driest time to visit Greenville when rainfall is around 3.6 in.

If weather is an important factor for your trip to Greenville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

What is the cheapest day to fly round-trip from Panama City, Florida to Greenville?

Users have found that flying from Panama City, Florida to Greenville on a Monday typically leans towards higher prices. However, this doesn’t mean you still can’t find a deal. Flexibility with other aspects of your flight can still land a great price for your trip.

What is the cheapest month to fly from Panama City, Florida to Greenville?

Due to multiple factors, expect to potentially pay more when booking in April. For low rates, June can be a great choice for travel to Greenville. Flights to Greenville from Panama City, Florida in June are about $448 on average during June, but can be found for as low as $242.

Can I find deals for flights from Panama City to Greenville that include hotel bookings?

Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to Greenville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

Can I find deals for business class flights from Panama City to Greenville?

Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$174+ Flights from Panama City, FL to Greenville

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Cheap flight deals from Panama City to Greenville

Round-trip from	$307 (American Airlines)
One-way from	$174 (American Airlines)
Popular in	April
Cheapest in	June
Average price	$396

From Panama City NW Florida Beaches to Greenville

Search Deals

One-way flight from Panama City NW Florida Beaches to Greenville

Search Deals

Highest demand for flights based on searches. 20% potential increase in price ($118 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 8% potential price decrease ($34 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Panama City to Greenville

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Fri 8/12:35 pmECP - GSP

1 stop4h 20mAmerican Airlines

Sun 8/36:51 amGSP - ECP

1 stop4h 22mAmerican Airlines

Deal found 6/30

$307

Fri 9/2610:40 amECP - GSP

1 stop6h 25mSouthwest

Sun 9/287:15 amGSP - ECP

2 stops11h 25mSouthwest

Deal found 7/2

$328

Sat 7/266:00 amECP - GSP

1 stop3h 59mDelta

Mon 7/285:30 amGSP - ECP

1 stop4h 03mDelta

Deal found 7/1

$428

Fri 7/185:02 pmECP - GSP

2 stops21h 00mUnited Airlines

Tue 7/2210:27 amGSP - ECP

2 stops24h 29mUnited Airlines

Deal found 7/3

$874

Best flights from Panama City to Greenville
Discover carefully curated flight deals from Panama City to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 3, 2025.

Fri 8/12:35 pmECP - GSP

1 stop4h 20mAmerican Airlines

Sun 8/36:51 amGSP - ECP

1 stop4h 22mAmerican Airlines

Deal found 6/30

$307

Fri 9/2610:40 amECP - GSP

1 stop6h 25mSouthwest

Sun 9/287:15 amGSP - ECP

2 stops11h 25mSouthwest

Deal found 7/2

$328

Sat 7/266:00 amECP - GSP

1 stop3h 59mDelta

Mon 7/285:30 amGSP - ECP

1 stop4h 03mDelta

Deal found 7/1

$428

Fri 7/185:02 pmECP - GSP

2 stops21h 00mUnited Airlines

Tue 7/2210:27 amGSP - ECP

2 stops24h 29mUnited Airlines

Deal found 7/3

$874

Last-minute flights from Panama City to Greenville
Discover last-minute flight deals from Panama City to Greenville. Data last updated July 3, 2025 and is based on user searches.

Sat 7/125:30 amECP - GSP

1 stop4h 08mAmerican Airlines

Sat 7/122:33 pmGSP - ECP

1 stop4h 52mAmerican Airlines

Deal found 7/2

$501

Sat 7/126:30 amECP - GSP

2 stops9h 24mUnited Airlines

Sat 7/127:45 pmGSP - ECP

2 stops18h 38mUnited Airlines

Deal found 7/2

$1,030

Fri 7/185:02 pmECP - GSP

2 stops21h 00mUnited Airlines

Tue 7/2210:27 amGSP - ECP

2 stops24h 29mUnited Airlines

Deal found 7/3

$874

Thu 7/245:50 amECP - GSP

2 stops10h 15mSouthwest

Wed 7/3010:25 amGSP - ECP

1 stop5h 55mSouthwest

Deal found 7/1

$378

Sat 7/266:00 amECP - GSP

1 stop3h 59mDelta

Mon 7/285:30 amGSP - ECP

1 stop4h 03mDelta

Deal found 7/1

$428

Fri 8/12:35 pmECP - GSP

1 stop4h 20mAmerican Airlines

Sun 8/36:51 amGSP - ECP

1 stop4h 22mAmerican Airlines

Deal found 6/30

$307

One-way flights from Panama City to Greenville
Search for one-way flight options from Panama City to Greenville. Find affordable one-way fares based on user searches. Data last updated July 3, 2025.

Wed 7/305:30 amECP - GSP

1 stop4h 13mAmerican Airlines

Deal found 7/1

$174

Wed 7/309:30 amECP - GSP

2 stops7h 55mSouthwest

Deal found 7/1

$179

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Fri 8/1

2:35 pm-7:55 pm

1 stop4h 20m

Greenville

Sun 8/3

6:51 am-10:13 am

1 stop4h 22m

$307

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Fri 9/26

10:40 am-6:05 pm

1 stop6h 25m

Greenville

Sun 9/28

7:15 am-5:40 pm

2 stops11h 25m

$328

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sat 7/26

6:00 am-10:59 am

1 stop3h 59m

Greenville

Mon 7/28

5:30 am-8:33 am

1 stop4h 03m

$428

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Fri 7/18

5:02 pm-3:02 pm

2 stops21h 00m

Greenville

Tue 7/22

10:27 am-9:56 am

2 stops24h 29m

$874

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 7/30

5:30 am-10:43 am

1 stop4h 13m

$174

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 7/30

9:30 am-6:25 pm

2 stops7h 55m

$179

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Greenville

What is the cheapest month to book a flight from Panama City, Florida to Greenville?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Greenville (average of $329). Flying from Panama City, Florida to Greenville in March is currently the most expensive (average of $385). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to GSP?

When flying from Panama City, Florida to Greenville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 39% versus a flight in the morning.

Reviews of airlines servicing Greenville

Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Panama City to Greenville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,266 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Southwest

8.0

Very good

4,266 reviews

Southwest

8.0

Very good

4,266 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Delta

8.0

Very good

7,982 reviews

Southwest

8.0

Very good

4,266 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

United Airlines

7.4

Good

8,861 reviews

Southwest

8.0

Very good

4,266 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,266 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

What are the cheapest airlines flying from Panama City, Florida to Greenville round-trip?
Currently priced at $307, American Airlines will fly you from Panama City, Florida to Greenville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Southwest and Delta - these airlines can fly you to your destination from $328 and $428, respectively. You may be able to fly from Panama City, Florida to Greenville for 31% less than the average price by searching for these airlines.
Can I find deals for flights from Panama City to Greenville that include hotel bookings?
Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Greenville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.
Can I find deals for business class flights from Panama City to Greenville?
Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City, Florida to Greenville?
Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Greenville (average of $329). Flying from Panama City, Florida to Greenville in March is currently the most expensive (average of $385). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Other flights to Greenville

Top 2 airlines flying from Panama City to Greenville

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$242	Average$491	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$256	Average$476	FlexibilityNo cancel fee	On-time71%

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$174+ Cheap flights from Panama City, FL to Greenville (ECP - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/30. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Greenville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama City to Greenville

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Panama City to Greenville

Cheapest flights from Panama City to GreenvilleExplore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Greenville

What is the cheapest month to book a flight from Panama City, Florida to Greenville?

What is the cheapest time of day to fly from ECP to GSP?

Find hourly flight availability from Panama City to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 3, 2025.

Reviews of airlines servicing Greenville

Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Panama City to Greenville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Panama City, Florida to Greenville round-trip?

Can I find deals for flights from Panama City to Greenville that include hotel bookings?

How can I find direct flights from Panama City to Greenville?

Can I find deals for business class flights from Panama City to Greenville?

What is the cheapest month to book a flight from Panama City, Florida to Greenville?

Traveling to a place near Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Greenville

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Panama City to Greenville

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Travel Smart

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.