$70+ Cheap flights from Iowa to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Apr 29 — May 61
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to Missouri with Cheapflights
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Cheapest flights from Iowa to MissouriExplore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 30, 2026.
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:19 pm
OMA
- STL
1 stop23h 04m
Frontier
Mon 5/118:08 pm
STL
- OMA
1 stop23h 16m
Frontier
Deal found 3/28![Frontier logo]()
$191
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:10 am
DSM
- STL
1 stop6h 55m
Delta
Tue 4/145:35 pm
STL
- DSM
1 stop3h 37m
Delta
Deal found 3/25![Delta logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:19 pm
OMA
- STL
1 stop23h 04m
Frontier
Mon 5/118:08 pm
STL
- OMA
1 stop23h 16m
Frontier
Deal found 3/28![Frontier logo]()
$211
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:55 am
DSM
- STL
2 stops6h 05m
Southwest
Wed 4/153:55 pm
STL
- DSM
1 stop6h 15m
Southwest
Deal found 3/26![Southwest logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:19 pm
OMA
- STL
2 stops12h 36m
Frontier
Mon 5/118:08 pm
STL
- OMA
1 stop23h 16m
Frontier
Deal found 3/28![Frontier logo]()
$218
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:15 am
DSM
- STL
1 stop6h 32m
United Airlines
Tue 5/125:28 pm
STL
- DSM
1 stop5h 56m
United Airlines
Deal found 3/26![United Airlines logo]()
$219
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:30 am
DSM
- STL
2 stops7h 20m
Southwest
Tue 4/143:55 pm
STL
- DSM
1 stop5h 20m
Southwest
Deal found 3/25![Southwest logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:43 pm
OMA
- STL
2 stops20h 53m
Frontier
Mon 5/118:08 pm
STL
- OMA
1 stop23h 16m
Frontier
Deal found 3/28![Frontier logo]()
$224
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/182:10 pm
DSM
- STL
1 stop7h 05m
Southwest
Tue 4/218:35 am
STL
- DSM
1 stop5h 30m
Southwest
Deal found 3/26![Southwest logo]()
$225
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:35 am
DSM
- STL
2 stops8h 00m
Southwest
Tue 5/123:55 pm
STL
- DSM
1 stop5h 20m
Southwest
Deal found 3/26![Southwest logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/148:19 pm
OMA
- STL
1 stop23h 04m
Frontier
Mon 5/188:08 pm
STL
- OMA
1 stop23h 16m
Frontier
Deal found 3/25![Frontier logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:19 pm
OMA
- STL
2 stops12h 36m
Frontier
Sat 5/98:08 pm
STL
- OMA
1 stop23h 26m
Frontier
Deal found 3/28![Frontier logo]()
$236
Best flights from Iowa to MissouriDiscover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 30, 2026.
Discover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 30, 2026.
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:10 am
DSM
- STL
1 stop6h 55m
Delta
Tue 4/145:35 pm
STL
- DSM
1 stop3h 37m
Delta
Deal found 3/25![Delta logo]()
$205
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/304:20 pm
DSM
- STL
1 stop6h 25m
Southwest
Thu 5/77:20 am
STL
- DSM
1 stop4h 25m
Southwest
Deal found 3/26![Southwest logo]()
$245
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:23 am
DSM
- STL
1 stop4h 23m
United Airlines
Wed 6/36:00 am
STL
- DSM
1 stop4h 27m
United Airlines
Deal found 3/25![United Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:35 pm
OMA
- STL
1 stop4h 11m
American Airlines
Mon 4/279:10 am
STL
- OMA
1 stop7h 12m
American Airlines
Deal found 3/29![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:19 pm
OMA
- MCI
1 stop17h 30m
Multiple Airlines
Thu 5/78:44 am
MCI
- OMA
1 stop24h 47m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:06 pm
OMA
- SGF
1 stop14h 20m
Allegiant Air
Thu 4/1610:24 am
SGF
- OMA
1 stop23h 07m
Allegiant Air
Deal found 3/28![Allegiant Air logo]()
$450
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/84:20 pm
DSM
- STL
1 stop6h 25m
Southwest
Tue 5/123:10 pm
STL
- DSM
2 stops7h 00m
Southwest
Deal found 3/26![Southwest logo]()
$248
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:25 am
DSM
- STL
1 stop3h 40m
Southwest
Tue 5/193:10 pm
STL
- DSM
2 stops7h 00m
Southwest
Deal found 3/25![Southwest logo]()
$263
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:55 am
OMA
- STL
1 stop4h 37m
Delta
Sat 5/212:23 pm
STL
- OMA
1 stop4h 39m
Delta
Deal found 3/25![Delta logo]()
$295
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:37 pm
LSE
- MCI
1 stop5h 22m
American Airlines
Sat 5/25:33 am
MCI
- LSE
1 stop4h 02m
American Airlines
Deal found 3/25![American Airlines logo]()
$298
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/53:01 pm
OMA
- STL
1 stop7h 29m
United Airlines
Wed 5/68:21 am
STL
- OMA
1 stop3h 58m
United Airlines
Deal found 3/25![United Airlines logo]()
$315
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/164:20 pm
DSM
- STL
1 stop6h 25m
Southwest
Fri 4/175:40 am
STL
- DSM
1 stop6h 05m
Southwest
Deal found 3/25![Southwest logo]()
$266
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:37 pm
LSE
- MCI
1 stop5h 22m
American Airlines
Sat 4/255:33 am
MCI
- LSE
1 stop4h 02m
American Airlines
Deal found 3/26![American Airlines logo]()
$298
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:00 am
CID
- MCI
1 stop4h 32m
Delta
Sun 8/236:30 am
MCI
- CID
1 stop4h 57m
Delta
Deal found 3/27![Delta logo]()
$299
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:37 pm
LSE
- STL
1 stop5h 09m
American Airlines
Mon 4/278:03 pm
STL
- LSE
1 stop3h 51m
American Airlines
Deal found 3/27![American Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:20 pm
OMA
- STL
1 stop4h 30m
Southwest
Mon 4/279:40 pm
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 3/29![Southwest logo]()
$279
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:49 pm
OMA
- STL
1 stop4h 30m
United Airlines
Sun 5/177:45 am
STL
- OMA
1 stop6h 36m
United Airlines
Deal found 3/27![United Airlines logo]()
$340
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:31 pm
DSM
- STL
1 stop5h 05m
Delta
Thu 4/236:20 am
STL
- DSM
1 stop3h 56m
Delta
Deal found 3/29![Delta logo]()
$311
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:40 am
LSE
- COU
1 stop4h 06m
American Airlines
Tue 4/1412:06 pm
COU
- LSE
2 stops11h 48m
American Airlines
Deal found 3/26![American Airlines logo]()
$303
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:15 am
OMA
- STL
1 stop5h 15m
Southwest
Mon 4/209:40 pm
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 3/28![Southwest logo]()
$279
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:15 am
DSM
- STL
1 stop6h 55m
Delta
Sun 5/316:21 am
STL
- DSM
1 stop3h 55m
Delta
Deal found 3/28![Delta logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:19 pm
OMA
- MCI
2 stops13h 10m
Multiple Airlines
Sun 5/177:03 pm
MCI
- OMA
1 stop16h 41m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$433
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:00 pm
OMA
- SGF
1 stop4h 42m
United Airlines
Sat 6/276:00 am
SGF
- OMA
1 stop4h 27m
United Airlines
Deal found 3/29![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:05 am
LSE
- STL
2 stops9h 25m
American Airlines
Tue 4/215:21 pm
STL
- LSE
1 stop6h 33m
American Airlines
Deal found 3/27![American Airlines logo]()
$304
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:25 am
DSM
- STL
1 stop3h 40m
Southwest
Mon 4/135:40 am
STL
- DSM
1 stop6h 05m
Southwest
Deal found 3/25![Southwest logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:45 pm
CID
- MCI
2 stops22h 44m
Multiple Airlines
Sun 5/108:44 am
MCI
- CID
1 stop8h 32m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$438
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:37 pm
LSE
- STL
1 stop5h 09m
American Airlines
Tue 4/145:51 am
STL
- LSE
1 stop3h 44m
American Airlines
Deal found 3/26![American Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:34 am
CID
- MCI
1 stop3h 53m
United Airlines
Wed 4/298:00 am
MCI
- CID
1 stop4h 47m
United Airlines
Deal found 3/27![United Airlines logo]()
$374
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:20 am
OMA
- STL
1 stop3h 45m
Southwest
Wed 5/65:45 am
STL
- OMA
2 stops7h 30m
Southwest
Deal found 3/26![Southwest logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:59 pm
OMA
- MCI
1 stop22h 59m
Multiple Airlines
Sun 4/126:04 pm
MCI
- OMA
1 stop17h 40m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$443
Last-minute flights from Iowa to MissouriDiscover last-minute flight deals from Iowa to Missouri. Data last updated March 30, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to Missouri. Data last updated March 30, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:59 pm
OMA
- STL
1 stop12h 49m
Frontier
Sat 4/118:16 pm
STL
- OMA
1 stop23h 58m
Frontier
Deal found 3/27![Frontier logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:59 pm
OMA
- STL
1 stop12h 49m
Frontier
Tue 4/144:59 pm
STL
- OMA
2 stops51h 14m
Frontier
Deal found 3/26![Frontier logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/128:59 pm
OMA
- STL
1 stop12h 49m
Frontier
Thu 4/164:59 pm
STL
- OMA
2 stops27h 05m
Frontier
Deal found 3/28![Frontier logo]()
$277
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:10 am
DSM
- STL
1 stop6h 55m
Delta
Tue 4/145:35 pm
STL
- DSM
1 stop3h 37m
Delta
Deal found 3/25![Delta logo]()
$205
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:30 am
DSM
- STL
2 stops7h 20m
Southwest
Tue 4/143:55 pm
STL
- DSM
1 stop5h 20m
Southwest
Deal found 3/25![Southwest logo]()
$221
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:05 pm
OMA
- STL
1 stop4h 47m
United Airlines
Thu 4/169:10 am
STL
- OMA
1 stop5h 10m
United Airlines
Deal found 3/26![United Airlines logo]()
$293
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:55 am
DSM
- STL
2 stops6h 05m
Southwest
Wed 4/153:55 pm
STL
- DSM
1 stop6h 15m
Southwest
Deal found 3/26![Southwest logo]()
$215
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:34 pm
OMA
- STL
1 stop4h 12m
American Airlines
Wed 4/227:00 am
STL
- OMA
1 stop7h 00m
American Airlines
Deal found 3/25![American Airlines logo]()
$255
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:25 am
DSM
- STL
1 stop4h 50m
Southwest
Sat 4/185:40 am
STL
- DSM
1 stop5h 50m
Southwest
Deal found 3/25![Southwest logo]()
$245
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/182:10 pm
DSM
- STL
1 stop7h 05m
Southwest
Tue 4/218:35 am
STL
- DSM
1 stop5h 30m
Southwest
Deal found 3/26![Southwest logo]()
$225
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:50 am
OMA
- STL
Nonstop1h 15m
Southwest
Mon 4/209:40 pm
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 3/28![Southwest logo]()
$269
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/252:44 pm
DSM
- STL
1 stop4h 27m
Delta
Sat 5/210:50 am
STL
- DSM
1 stop6h 12m
Delta
Deal found 3/26![Delta logo]()
$239
One-way flights from Iowa to MissouriSearch for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated March 30, 2026.
Search for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated March 30, 2026.
This Frontier deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- STL
1 stop5h 17m
Frontier
Deal found 3/29![Frontier logo]()
$70
This Frontier deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- STL
1 stop5h 07m
Frontier
Deal found 3/29![Frontier logo]()
$90
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- STL
1 stop29h 07m
Frontier
Deal found 3/25![Frontier logo]()
$91
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:49 pm
OMA
- MCI
1 stop17h 17m
Frontier
Deal found 3/28![Frontier logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:19 pm
OMA
- STL
1 stop23h 04m
Frontier
Deal found 3/28![Frontier logo]()
$99
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:31 pm
DSM
- STL
1 stop5h 05m
Delta
Deal found 3/26![Delta logo]()
$100
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2210:56 am
DSM
- STL
1 stop5h 54m
Delta
Deal found 3/26![Delta logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:49 pm
OMA
- STL
1 stop22h 43m
Frontier
Deal found 3/27![Frontier logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:58 pm
OMA
- STL
1 stop22h 23m
Frontier
Deal found 3/27![Frontier logo]()
$113
This Frontier deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/262:16 pm
DSM
- STL
1 stop5h 07m
Frontier
Deal found 3/29![Frontier logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:49 pm
OMA
- MCI
1 stop17h 17m
Frontier
Deal found 3/25![Frontier logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:49 pm
OMA
- STL
1 stop22h 43m
Frontier
Deal found 3/29![Frontier logo]()
$117
Find flight deals from Iowa to Missouri
Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated March 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $191 (Kiwi.com) |
One-way from | $70 (Frontier) |
Popular in | July |
Cheapest in | September |
Average price | $243 |
Good round-trip deal | $105 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 4/14
6:10 am-1:05 pm
1 stop6h 55m
Lambert-St Louis
Tue 4/14
5:35 pm-9:12 pm
1 stop3h 37m
$205
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Thu 4/30
4:20 pm-10:45 pm
1 stop6h 25m
Lambert-St Louis
Thu 5/7
7:20 am-11:45 am
1 stop4h 25m
$245
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Fri 5/8
4:20 pm-10:45 pm
1 stop6h 25m
Lambert-St Louis
Tue 5/12
3:10 pm-10:10 pm
2 stops7h 00m
$248
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Mon 5/18
5:25 am-9:05 am
1 stop3h 40m
Lambert-St Louis
Tue 5/19
3:10 pm-10:10 pm
2 stops7h 00m
$263
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Thu 4/16
4:20 pm-10:45 pm
1 stop6h 25m
Lambert-St Louis
Fri 4/17
5:40 am-11:45 am
1 stop6h 05m
$266
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 6/2
11:23 am-3:46 pm
1 stop4h 23m
Lambert-St Louis
Wed 6/3
6:00 am-10:27 am
1 stop4h 27m
$269
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Thu 4/23
7:35 pm-11:46 pm
1 stop4h 11m
Lambert-St Louis
Mon 4/27
9:10 am-4:22 pm
1 stop7h 12m
$279
Quickest round-trip
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Thu 4/23
7:20 pm-11:50 pm
1 stop4h 30m
Lambert-St Louis
Mon 4/27
9:40 pm-11:00 pm
Nonstop1h 20m
$279
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Sat 4/18
5:15 am-10:30 am
1 stop5h 15m
Lambert-St Louis
Mon 4/20
9:40 pm-11:00 pm
Nonstop1h 20m
$279
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Thu 4/9
5:25 am-9:05 am
1 stop3h 40m
Lambert-St Louis
Mon 4/13
5:40 am-11:45 am
1 stop6h 05m
$285
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
DSM-STL
OMA-MCI
OMA-STL
OMA-SGF
LSE-MCI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to Missouri
USIA-USMO
DSM-STL
OMA-MCI
OMA-STL
OMA-SGF
What is the cheapest month to book a flight from Iowa to Missouri?
Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $93). Flying from Iowa to Missouri in January is currently the most expensive (average of $275). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Iowa to Missouri?
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated March 30, 2026.
Peruse reviews from past customers who have flown with Southwest,United Airlines, andAmerican Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.0
Crew
8.6
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Crew
8.6
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Crew
8.6
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Crew
8.6
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Iowa to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to Missouri by cabin class
Find flights from Iowa to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and Missouri flights
Browse other Iowa and Missouri flight options. Last updated on March 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to Iowa after your stay in Missouri
Iowa to Missouri flights
Consider these flights traveling from Iowa to Missouri.
Top 3 airlines flying from Iowa to Missouri
Discover the top 3 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$107 | Average$253 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$218 | Average$418 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$218 | Average$297 | FlexibilityNo cancel fee | On-time71% |