$76+ Cheap flights from Iowa to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
May 22 — May 291
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Iowa to Missouri with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to Missouri
Cheapest
Best
Last-minute
One-way
Cheapest flights from Iowa to MissouriExplore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2026.
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2026.
This Frontier deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- STL
1 stop5h 07m
Frontier
Thu 6/48:08 pm
STL
- DSM
1 stop17h 23m
Frontier
Deal found 4/19![Frontier logo]()
$181
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:15 am
DSM
- STL
1 stop6h 55m
Delta
Tue 5/266:21 am
STL
- DSM
1 stop3h 55m
Delta
Deal found 4/21![Delta logo]()
$212
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:27 am
DSM
- STL
1 stop6h 55m
Delta
Wed 5/138:53 am
STL
- DSM
1 stop3h 31m
Delta
Deal found 4/22![Delta logo]()
$215
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:30 pm
DSM
- STL
1 stop4h 40m
Southwest
Wed 5/133:10 pm
STL
- DSM
2 stops7h 00m
Southwest
Deal found 4/22![Southwest logo]()
$221
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:41 pm
DSM
- STL
1 stop5h 18m
Delta
Mon 5/186:21 am
STL
- DSM
1 stop3h 55m
Delta
Deal found 4/21![Delta logo]()
$255
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1912:35 pm
OMA
- STL
1 stop7h 40m
Southwest
Tue 5/268:50 pm
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 4/20![Southwest logo]()
$258
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:34 am
OMA
- STL
1 stop3h 58m
Delta
Tue 5/265:36 pm
STL
- OMA
1 stop5h 20m
Delta
Deal found 4/20![Delta logo]()
$261
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:30 am
DSM
- STL
1 stop4h 00m
Southwest
Mon 5/255:40 am
STL
- DSM
1 stop6h 05m
Southwest
Deal found 4/22![Southwest logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:19 pm
OMA
- STL
2 stops12h 36m
Frontier
Mon 6/18:08 pm
STL
- OMA
1 stop23h 16m
Frontier
Deal found 4/21![Frontier logo]()
$276
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:11 am
DSM
- STL
1 stop5h 30m
American Airlines
Fri 5/155:51 am
STL
- DSM
1 stop4h 40m
American Airlines
Deal found 4/22![American Airlines logo]()
$276
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:00 am
DSM
- STL
1 stop6h 11m
United Airlines
Wed 6/35:10 am
STL
- DSM
1 stop5h 32m
United Airlines
Deal found 4/20![United Airlines logo]()
$279
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:34 pm
OMA
- STL
1 stop4h 20m
American Airlines
Tue 5/266:12 pm
STL
- OMA
1 stop6h 10m
American Airlines
Deal found 4/22![American Airlines logo]()
$280
Best flights from Iowa to MissouriDiscover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 22, 2026.
Discover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 22, 2026.
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:27 am
DSM
- STL
1 stop6h 55m
Delta
Wed 5/138:53 am
STL
- DSM
1 stop3h 31m
Delta
Deal found 4/22![Delta logo]()
$215
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1912:35 pm
OMA
- STL
1 stop7h 40m
Southwest
Tue 5/268:50 pm
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 4/20![Southwest logo]()
$258
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:00 am
DSM
- STL
1 stop6h 11m
United Airlines
Wed 6/35:10 am
STL
- DSM
1 stop5h 32m
United Airlines
Deal found 4/20![United Airlines logo]()
$279
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:40 am
LSE
- STL
1 stop6h 07m
American Airlines
Sat 5/95:51 am
STL
- LSE
1 stop3h 33m
American Airlines
Deal found 4/19![American Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:30 am
DSM
- STL
1 stop4h 00m
Southwest
Tue 5/262:30 pm
STL
- DSM
2 stops7h 40m
Southwest
Deal found 4/21![Southwest logo]()
$285
This United Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/198:00 am
CID
- MCI
1 stop6h 26m
United Airlines
Tue 5/265:00 pm
MCI
- CID
1 stop4h 36m
United Airlines
Deal found 4/19![United Airlines logo]()
$299
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/54:22 pm
CID
- MCI
1 stop6h 39m
Delta
Sat 5/96:19 am
MCI
- CID
1 stop4h 57m
Delta
Deal found 4/20![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:55 pm
DSM
- STL
1 stop4h 50m
Southwest
Sat 6/134:45 pm
STL
- DSM
1 stop5h 10m
Southwest
Deal found 4/22![Southwest logo]()
$287
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/25:00 am
DSM
- STL
1 stop5h 34m
United Airlines
Sun 7/58:35 pm
STL
- DSM
1 stop4h 10m
United Airlines
Deal found 4/20![United Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/14:20 pm
DSM
- STL
1 stop6h 25m
Southwest
Mon 6/86:30 pm
STL
- DSM
1 stop5h 00m
Southwest
Deal found 4/17![Southwest logo]()
$297
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:40 am
LSE
- STL
1 stop6h 07m
American Airlines
Sun 5/175:51 am
STL
- LSE
1 stop3h 33m
American Airlines
Deal found 4/22![American Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/278:00 am
DSM
- STL
1 stop4h 07m
United Airlines
Sun 7/55:33 pm
STL
- DSM
1 stop4h 07m
United Airlines
Deal found 4/19![United Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:42 am
OMA
- STL
1 stop5h 49m
Delta
Tue 5/128:53 am
STL
- OMA
1 stop3h 32m
Delta
Deal found 4/21![Delta logo]()
$359
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:25 am
DSM
- STL
1 stop3h 40m
Southwest
Mon 5/257:20 am
STL
- DSM
1 stop4h 25m
Southwest
Deal found 4/18![Southwest logo]()
$317
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/71:25 pm
OMA
- STL
1 stop3h 21m
Delta
Mon 5/115:36 pm
STL
- OMA
1 stop5h 20m
Delta
Deal found 4/17![Delta logo]()
$365
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:27 pm
OMA
- STL
1 stop6h 30m
United Airlines
Wed 5/276:00 am
STL
- OMA
1 stop6h 16m
United Airlines
Deal found 4/17![United Airlines logo]()
$337
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:36 pm
LSE
- MCI
1 stop5h 40m
American Airlines
Sun 5/175:35 am
MCI
- LSE
1 stop3h 49m
American Airlines
Deal found 4/22![American Airlines logo]()
$412
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:40 pm
DSM
- MCI
1 stop6h 35m
Southwest
Fri 6/125:25 pm
MCI
- DSM
1 stop6h 05m
Southwest
Deal found 4/21![Southwest logo]()
$332
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/52:55 pm
OMA
- SGF
1 stop4h 16m
American Airlines
Sat 5/99:54 am
SGF
- OMA
1 stop4h 21m
American Airlines
Deal found 4/19![American Airlines logo]()
$415
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:55 am
OMA
- STL
1 stop4h 12m
United Airlines
Tue 6/95:10 am
STL
- OMA
1 stop7h 32m
United Airlines
Deal found 4/21![United Airlines logo]()
$350
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/201:55 pm
OMA
- STL
2 stops8h 25m
Southwest
Wed 5/271:45 pm
STL
- OMA
1 stop8h 35m
Southwest
Deal found 4/20![Southwest logo]()
$334
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:40 am
LSE
- MCI
2 stops8h 03m
American Airlines
Sun 5/175:35 am
MCI
- LSE
1 stop3h 49m
American Airlines
Deal found 4/22![American Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:00 am
OMA
- COU
1 stop5h 55m
United Airlines
Sat 8/298:00 am
COU
- OMA
1 stop4h 18m
United Airlines
Deal found 4/17![United Airlines logo]()
$358
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1912:35 pm
OMA
- STL
1 stop7h 40m
Southwest
Sat 5/237:00 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 4/21![Southwest logo]()
$341
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:00 am
LSE
- MCI
2 stops11h 22m
American Airlines
Tue 7/2112:16 pm
MCI
- LSE
2 stops11h 43m
American Airlines
Deal found 4/18![American Airlines logo]()
$434
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/298:00 am
CID
- MCI
1 stop4h 22m
United Airlines
Tue 9/111:40 am
MCI
- CID
1 stop5h 20m
United Airlines
Deal found 4/17![United Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/164:40 pm
DSM
- MCI
1 stop6h 35m
Southwest
Sun 7/197:20 pm
MCI
- DSM
1 stop4h 25m
Southwest
Deal found 4/22![Southwest logo]()
$347
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/163:13 pm
CID
- MCI
1 stop5h 28m
United Airlines
Sat 5/233:16 pm
MCI
- CID
1 stop6h 20m
United Airlines
Deal found 4/18![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2711:52 am
LSE
- MCI
2 stops11h 05m
American Airlines
Sat 5/307:42 pm
MCI
- LSE
1 stop4h 24m
American Airlines
Deal found 4/18![American Airlines logo]()
$459
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:40 pm
OMA
- STL
Nonstop1h 15m
Southwest
Tue 5/268:50 pm
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 4/21![Southwest logo]()
$349
Last-minute flights from Iowa to MissouriDiscover last-minute flight deals from Iowa to Missouri. Data last updated April 22, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to Missouri. Data last updated April 22, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:41 pm
DSM
- STL
1 stop5h 18m
Delta
Mon 5/186:21 am
STL
- DSM
1 stop3h 55m
Delta
Deal found 4/21![Delta logo]()
$255
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:27 am
DSM
- STL
1 stop6h 55m
Delta
Wed 5/138:53 am
STL
- DSM
1 stop3h 31m
Delta
Deal found 4/22![Delta logo]()
$215
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:30 pm
DSM
- STL
1 stop4h 40m
Southwest
Wed 5/133:10 pm
STL
- DSM
2 stops7h 00m
Southwest
Deal found 4/22![Southwest logo]()
$221
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:30 am
DSM
- STL
1 stop4h 00m
Southwest
Mon 5/255:40 am
STL
- DSM
1 stop6h 05m
Southwest
Deal found 4/22![Southwest logo]()
$266
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:11 am
DSM
- STL
1 stop5h 30m
American Airlines
Fri 5/155:51 am
STL
- DSM
1 stop4h 40m
American Airlines
Deal found 4/22![American Airlines logo]()
$276
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:15 am
DSM
- STL
1 stop6h 55m
Delta
Tue 5/266:21 am
STL
- DSM
1 stop3h 55m
Delta
Deal found 4/21![Delta logo]()
$212
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1912:35 pm
OMA
- STL
1 stop7h 40m
Southwest
Tue 5/268:50 pm
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 4/20![Southwest logo]()
$258
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:34 am
OMA
- STL
1 stop3h 58m
Delta
Tue 5/265:36 pm
STL
- OMA
1 stop5h 20m
Delta
Deal found 4/20![Delta logo]()
$261
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:34 pm
OMA
- STL
1 stop4h 20m
American Airlines
Tue 5/266:12 pm
STL
- OMA
1 stop6h 10m
American Airlines
Deal found 4/22![American Airlines logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:19 pm
OMA
- STL
2 stops12h 36m
Frontier
Mon 6/18:08 pm
STL
- OMA
1 stop23h 16m
Frontier
Deal found 4/21![Frontier logo]()
$276
This Frontier deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- STL
1 stop5h 07m
Frontier
Thu 6/48:08 pm
STL
- DSM
1 stop17h 23m
Frontier
Deal found 4/19![Frontier logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:19 pm
OMA
- STL
1 stop23h 04m
Frontier
Tue 6/28:08 pm
STL
- OMA
1 stop23h 26m
Frontier
Deal found 4/21![Frontier logo]()
$284
One-way flights from Iowa to MissouriSearch for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated April 22, 2026.
Search for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated April 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/268:19 pm
OMA
- MCI
1 stop17h 30m
Frontier
Deal found 4/22![Frontier logo]()
$76
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:19 pm
OMA
- STL
1 stop23h 04m
Frontier
Deal found 4/18![Frontier logo]()
$85
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:19 pm
OMA
- STL
1 stop23h 04m
Frontier
Deal found 4/18![Frontier logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:19 pm
OMA
- STL
2 stops21h 14m
Frontier
Deal found 4/18![Frontier logo]()
$118
This Trip.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:49 pm
OMA
- STL
1 stop22h 43m
Frontier
Deal found 4/22![Frontier logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/108:19 pm
OMA
- STL
1 stop23h 04m
Frontier
Deal found 4/18![Frontier logo]()
$123
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/188:03 pm
DSM
- STL
1 stop3h 53m
American Airlines
Deal found 4/20![American Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:04 pm
LSE
- MCI
2 stops17h 45m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$133
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:34 am
OMA
- STL
1 stop3h 58m
Delta
Deal found 4/21![Delta logo]()
$134
This Expedia deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/242:16 pm
DSM
- STL
1 stop5h 07m
Frontier
Deal found 4/21![Frontier logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:01 pm
OMA
- STL
2 stops23h 32m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$140
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/171:10 pm
OMA
- STL
2 stops7h 15m
Southwest
Deal found 4/17![Southwest logo]()
$144
Find flight deals from Iowa to Missouri
Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated April 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $181 (Frontier) |
One-way from | $76 (Kiwi.com) |
Popular in | July |
Cheapest in | May |
Average price | $328 |
Good round-trip deal | $105 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 5/12
5:27 am-12:22 pm
1 stop6h 55m
Lambert-St Louis
Wed 5/13
8:53 am-12:24 pm
1 stop3h 31m
$215
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Tue 5/19
12:35 pm-8:15 pm
1 stop7h 40m
Lambert-St Louis
Tue 5/26
8:50 pm-10:10 pm
Nonstop1h 20m
$258
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 6/2
6:00 am-12:11 pm
1 stop6h 11m
Lambert-St Louis
Wed 6/3
5:10 am-10:42 am
1 stop5h 32m
$279
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 5/19
5:30 am-9:30 am
1 stop4h 00m
Lambert-St Louis
Tue 5/26
2:30 pm-10:10 pm
2 stops7h 40m
$285
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Sat 6/6
6:55 pm-11:45 pm
1 stop4h 50m
Lambert-St Louis
Sat 6/13
4:45 pm-9:55 pm
1 stop5h 10m
$287
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Mon 6/1
4:20 pm-10:45 pm
1 stop6h 25m
Lambert-St Louis
Mon 6/8
6:30 pm-11:30 pm
1 stop5h 00m
$297
Cedar RapidsKansas City
CID - MCI
CIDMCI
Cedar Rapids
Tue 5/19
8:00 am-2:26 pm
1 stop6h 26m
Kansas City
Tue 5/26
5:00 pm-9:36 pm
1 stop4h 36m
$299
La CrosseSt. Louis
LSE - STL
LSESTL
La Crosse
Tue 5/5
5:40 am-11:47 am
1 stop6h 07m
Lambert-St Louis
Sat 5/9
5:51 am-9:24 am
1 stop3h 33m
$308
Cedar RapidsKansas City
CID - MCI
CIDMCI
Cedar Rapids
Tue 5/5
4:22 pm-11:01 pm
1 stop6h 39m
Kansas City
Sat 5/9
6:19 am-11:16 am
1 stop4h 57m
$309
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Thu 7/2
5:00 am-10:34 am
1 stop5h 34m
Lambert-St Louis
Sun 7/5
8:35 pm-12:45 am
1 stop4h 10m
$317
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
DSM-STL
OMA-STL
OMA-MCI
CID-MCI
OMA-SGF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to Missouri
USIA-USMO
DSM-STL
OMA-STL
OMA-MCI
CID-MCI
What is the cheapest month to book a flight from Iowa to Missouri?
Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $77). Flying from Iowa to Missouri in February is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Iowa to Missouri?
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated April 22, 2026.
Peruse reviews from past customers who have flown with Southwest,United Airlines, andAmerican Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Return Flight Options
Top destinations
Alternative routes for Iowa to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to Missouri by cabin class
Find flights from Iowa to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and Missouri flights
Browse other Iowa and Missouri flight options. Last updated on April 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to Iowa after your stay in Missouri
Iowa to Missouri flights
Consider these flights traveling from Iowa to Missouri.
Top 3 airlines flying from Iowa to Missouri
Discover the top 3 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$107 | Average$250 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$158 | Average$327 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$218 | Average$383 | FlexibilityNo cancel fee | On-time69% |