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Missouri

$59+ Cheap flights from Iowa to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/3. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Dec 5 — Dec 121
Fri 12/5
Fri 12/12
1 adult, Economy
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Cheap flight deals from Iowa to Missouri

Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated November 5, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$157
(Delta)

One-way from

$59
(Southwest)

Popular in

July

Cheapest in

September

Average price

$364

Good round-trip deal

$105 or less

Good one-way deal

$185 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
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From Iowa to Missouri
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One-way flight from Iowa to Missouri
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Highest demand for flights based on searches. 10% potential increase in price ($38 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Price to beat on a round-trip flight from Iowa to Missouri.
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Price to beat on a one-way flight from Iowa to Missouri.
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Find flight deals from Iowa to Missouri

Cheapest flights from Iowa to Missouri
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2025.

This Mytrip deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:24 pmOMA - STL
1 stop19h 50mFrontier
Sat 12/67:43 pmSTL - OMA
1 stop17h 48mFrontier
Deal found 11/3$159
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/178:51 pmOMA - MCI
1 stop20h 28mFrontier
Mon 11/248:28 pmMCI - OMA
1 stop23h 33mFrontier
Deal found 11/4$171
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:59 pmDSM - STL
1 stop6h 30mDelta
Thu 12/256:05 amSTL - DSM
1 stop5h 23mDelta
Deal found 11/2$181
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:00 amCID - MCI
1 stop5h 20mAmerican Airlines
Tue 12/97:00 amMCI - CID
1 stop3h 56mAmerican Airlines
Deal found 11/3$219
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:10 pmOMA - STL
1 stop7h 56mAmerican Airlines
Mon 12/157:35 pmSTL - OMA
1 stop4h 23mAmerican Airlines
Deal found 11/5$239
This Southwest deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:15 amDSM - STL
Nonstop1h 10mSouthwest
Sun 12/710:25 pmSTL - DSM
Nonstop1h 10mSouthwest
Deal found 11/4$250
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/411:29 amDSM - STL
1 stop5h 07mAmerican Airlines
Sun 12/75:14 amSTL - DSM
1 stop5h 16mAmerican Airlines
Deal found 11/4$254
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/411:23 amDSM - STL
1 stop6h 33mDelta
Sun 12/76:00 amSTL - DSM
1 stop4h 38mDelta
Deal found 11/3$255
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/182:59 pmOMA - SGF
1 stop5h 48mAmerican Airlines
Sat 11/227:11 pmSGF - OMA
1 stop4h 48mAmerican Airlines
Deal found 11/3$259
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/191:34 pmOMA - STL
1 stop7h 51mMultiple Airlines
Mon 12/227:43 pmSTL - OMA
1 stop24h 04mMultiple Airlines
Deal found 11/4$266
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/172:32 pmDSM - STL
1 stop18h 35mMultiple Airlines
Wed 11/197:45 pmSTL - DSM
2 stops44h 55mMultiple Airlines
Deal found 11/4$272
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/52:24 pmOMA - STL
1 stop19h 50mMultiple Airlines
Sun 12/71:16 pmSTL - OMA
1 stop23h 18mMultiple Airlines
Deal found 11/3$273

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.

Fly from

Iowa

Fly to

Missouri

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/3

10:57 am-4:47 pm

1 stop5h 50m

Lambert-St Louis

Wed 3/4

6:00 am-10:43 am

1 stop4h 43m

$157

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Thu 12/4

2:24 pm-10:14 am

1 stop19h 50m

Lambert-St Louis

Sat 12/6

7:43 pm-1:31 pm

1 stop17h 48m

$159

OmahaKansas City

OMA - MCI

OMAMCI

Omaha Eppley Airfield

Mon 11/17

8:51 pm-5:19 pm

1 stop20h 28m

Kansas City

Mon 11/24

8:28 pm-8:01 pm

1 stop23h 33m

$171

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 12/18

2:16 pm-9:57 pm

1 stop7h 41m

Lambert-St Louis

Thu 12/25

6:05 am-11:28 am

1 stop5h 23m

$181

Cedar RapidsKansas City

CID - MCI

CIDMCI

Cedar Rapids

Tue 12/2

5:00 am-10:20 am

1 stop5h 20m

Kansas City

Tue 12/9

7:00 am-10:56 am

1 stop3h 56m

$219

Cedar RapidsKansas City

CID - MCI

CIDMCI

Cedar Rapids

Fri 12/12

4:25 pm-11:10 pm

1 stop6h 45m

Kansas City

Sun 12/14

6:40 am-11:42 am

1 stop5h 02m

$219

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Thu 1/8

8:00 am-2:30 pm

1 stop6h 30m

Lambert-St Louis

Mon 1/12

4:49 pm-9:58 pm

1 stop5h 09m

$233

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Fri 12/12

3:10 pm-11:06 pm

1 stop7h 56m

Lambert-St Louis

Mon 12/15

7:35 pm-11:58 pm

1 stop4h 23m

$239

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 12/4

4:15 pm-5:20 pm

Nonstop1h 05m

Lambert-St Louis

Sun 12/7

3:15 pm-9:00 pm

1 stop5h 45m

$250

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 12/4

11:23 am-5:56 pm

1 stop6h 33m

Lambert-St Louis

Sun 12/7

6:00 am-10:38 am

1 stop4h 38m

$255

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Showing 1-10 of 60 results
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Best time to book a flight from Iowa to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Missouri

What is the cheapest month to book a flight from Iowa to Missouri?

Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $93). Flying from Iowa to Missouri in December is currently the most expensive (average of $233). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to MO?

Find hourly flight availability from Iowa to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 5, 2025.

It’s optimal to fly from Iowa to Missouri in the evening. By choosing this option you can save up to 24% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated November 5, 2025.
Peruse reviews from past customers who have flown with Southwest, United Airlines, and American Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,239 reviews

Crew

8.6

Entertainment

7.5

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,239 reviews
Southwest
8.0
Very good
4,239 reviews

Crew

8.6

Entertainment

7.5

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,000 reviews
Southwest
8.0
Very good
4,239 reviews

Crew

8.6

Entertainment

7.5

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,041 reviews
Southwest
8.0
Very good
4,239 reviews

Crew

8.6

Entertainment

7.5

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southern / Mokulele
6.1
Okay
25 reviews
Southwest
8.0
Very good
4,239 reviews

Crew

8.6

Entertainment

7.5

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Iowa to Missouri flight route?

    Within the past month, 30 users have taken a look at flights from Iowa to Missouri.

  • How long is the flight from Iowa to Missouri?

    A quick flight from Iowa to Missouri can take about 5h 20m. Delta provides one of the quickest options available for as low as $219. The distance between Iowa and Missouri is about 238 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Iowa to Missouri one-way?

    One-way options have recently been found by users for as low as $59 on Southwest. Other airlines that offer cheap prices include Frontier from $100 and United Airlines from $117 one-way.

  • Can I find deals for flights from Iowa to Missouri that include hotel bookings?

    Yes. In addition to deals on Iowa to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Missouri.

  • Can I find deals for business class flights from Iowa to Missouri?

    Yes. Cheapflights offers flight deals from Iowa to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Missouri?

    Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $93). Flying from Iowa to Missouri in December is currently the most expensive (average of $233). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to Missouri

Discover the top 4 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
AirlineCheapestAverageFlexibilityOn-time
Southern / MokuleleCheapest$61Average$85FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$97Average$296FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$218Average$295FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$218Average$418FlexibilityNo cancel feeOn-time69%

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