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Missouri

$49+ Cheap flights from Iowa to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Iowa to Missouri

Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated September 15, 2025.

Round-trip from

$97
(Southwest)

One-way from

$49
(Southwest)

Popular in

March

Cheapest in

January

Average price

$352

Good round-trip deal

$105 or less

Good one-way deal

$159 or less
From Iowa to Missouri
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One-way flight from Iowa to Missouri
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Highest demand for flights based on searches. 20% potential increase in price ($101 potential increase over avg. RT price).
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Cheapest flight prices on average. 16% potential price decrease ($56 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Iowa to Missouri.
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Price to beat on a one-way flight from Iowa to Missouri.
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Find flight deals from Iowa to Missouri

Cheapest flights from Iowa to Missouri
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/165:35 amDSM - STL
Nonstop1h 10mSouthwest
Tue 10/218:20 amSTL - DSM
Nonstop1h 10mSouthwest
Deal found 9/15$97
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2810:15 amDSM - STL
2 stops7h 10mSouthwest
Thu 10/3010:20 pmSTL - DSM
Nonstop1h 10mSouthwest
Deal found 9/15$112
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/318:51 pmOMA - STL
1 stop12h 16mFrontier
Sun 11/27:45 pmSTL - OMA
1 stop24h 21mFrontier
Deal found 9/15$150
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/287:40 pmOMA - STL
1 stop13h 26mFrontier
Thu 10/27:55 pmSTL - OMA
1 stop23h 55mFrontier
Deal found 9/13$152
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/116:12 pmDSM - STL
1 stop5h 06mAmerican Airlines
Sat 10/185:09 pmSTL - DSM
1 stop6h 07mAmerican Airlines
Deal found 9/14$159
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/145:47 amDSM - STL
1 stop4h 39mDelta
Tue 10/143:30 pmSTL - DSM
1 stop5h 33mDelta
Deal found 9/15$177
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/38:35 pmOMA - STL
1 stop12h 31mFrontier
Sun 10/57:55 pmSTL - OMA
1 stop17h 26mFrontier
Deal found 9/13$187
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/162:37 pmDSM - STL
1 stop18h 30mFrontier
Tue 10/217:52 pmSTL - DSM
1 stop18h 00mFrontier
Deal found 9/15$199
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:20 amDSM - STL
Nonstop1h 10mSouthwest
Tue 10/143:50 pmSTL - DSM
1 stop5h 05mSouthwest
Deal found 9/15$224
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/255:05 amOMA - SGF
1 stop4h 33mAmerican Airlines
Sat 11/16:48 pmSGF - OMA
1 stop4h 34mAmerican Airlines
Deal found 9/14$229
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/275:45 amDSM - STL
Nonstop1h 20mSouthwest
Sun 11/3010:55 pmSTL - DSM
Nonstop1h 10mSouthwest
Deal found 9/15$233
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/305:17 pmOMA - SGF
1 stop6h 23mUnited Airlines
Tue 10/77:45 amSGF - OMA
1 stop6h 36mUnited Airlines
Deal found 9/13$234

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.

Fly from

Iowa

Fly to

Missouri

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 10/28

6:20 am-7:30 am

Nonstop1h 10m

Lambert-St Louis

Thu 10/30

10:20 pm-11:30 pm

Nonstop1h 10m

$97

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 10/16

5:35 am-6:45 am

Nonstop1h 10m

Lambert-St Louis

Tue 10/21

8:20 am-9:30 am

Nonstop1h 10m

$97

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Fri 10/31

8:51 pm-9:07 am

1 stop12h 16m

Lambert-St Louis

Sun 11/2

7:45 pm-8:06 pm

1 stop24h 21m

$150

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Sun 9/28

7:40 pm-9:06 am

1 stop13h 26m

Lambert-St Louis

Thu 10/2

7:55 pm-7:50 pm

1 stop23h 55m

$152

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 1/8

10:55 am-4:05 pm

1 stop5h 10m

Lambert-St Louis

Mon 1/12

6:30 am-10:22 am

1 stop3h 52m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 10/14

5:47 am-10:26 am

1 stop4h 39m

Lambert-St Louis

Tue 10/14

3:30 pm-9:03 pm

1 stop5h 33m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/3

3:00 pm-10:14 pm

1 stop7h 14m

Lambert-St Louis

Wed 3/4

7:41 am-2:27 pm

1 stop6h 46m

$179

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/3

10:55 am-8:39 pm

2 stops9h 44m

Lambert-St Louis

Wed 3/4

6:30 am-10:22 am

1 stop3h 52m

$182

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Fri 10/3

8:35 pm-9:06 am

1 stop12h 31m

Lambert-St Louis

Sun 10/5

7:55 pm-1:21 pm

1 stop17h 26m

$187

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 10/14

6:20 am-7:30 am

Nonstop1h 10m

Lambert-St Louis

Tue 10/14

8:45 pm-9:50 pm

Nonstop1h 05m

$224

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 60 results
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Best time to book a flight from Iowa to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Missouri

What is the cheapest month to book a flight from Iowa to Missouri?

Currently, August is the cheapest month in which you can book a flight from Iowa to Missouri (average of $311). Flying from Iowa to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to MO?

Find hourly flight availability from Iowa to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Iowa to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated September 15, 2025.
Peruse reviews from past customers who have flown with Southwest, United Airlines, and American Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,929 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Iowa to Missouri flight route?

    Within the past month, 29 users have taken a look at flights from Iowa to Missouri.

  • How long is the flight from Iowa to Missouri?

    A quick flight from Iowa to Missouri can take about 1h 10m. Southwest provides one of the quickest options available for as low as $97. The distance between Iowa and Missouri is about 259 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Iowa to Missouri that include hotel bookings?

    Yes. In addition to deals on Iowa to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Missouri.

  • Can I find deals for business class flights from Iowa to Missouri?

    Yes. Cheapflights offers flight deals from Iowa to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Iowa to Missouri (average of $311). Flying from Iowa to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to Missouri

Discover the top 4 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
Southern / MokuleleCheapest$61Average$85FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$97Average$313FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$218Average$298FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$218Average$418FlexibilityNo cancel feeOn-time69%

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