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$67+ Cheap flights from Iowa to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Jun 6 — Jun 131
Sat 6/6
Sat 6/13
1 adult, Economy
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Cheap flight deals from Iowa to Missouri

Cheapest flights from Iowa to Missouri
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2026.

This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/268:19 pm
OMA
-
STL
2 stops12h 36m
Frontier
Wed 5/278:08 pm
STL
-
OMA
1 stop23h 26m
Frontier
Deal found 5/4$181
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:19 pm
OMA
-
STL
1 stop23h 04m
Frontier
Tue 6/26:33 pm
STL
-
OMA
2 stops25h 01m
Frontier
Deal found 5/4$222
This Mytrip deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/148:15 pm
OMA
-
STL
1 stop22h 38m
Frontier
Tue 6/168:08 pm
STL
-
OMA
1 stop23h 22m
Frontier
Deal found 5/6$239
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
-
STL
1 stop29h 07m
Multiple Airlines
Sun 6/76:33 pm
STL
-
DSM
2 stops28h 54m
Multiple Airlines
Deal found 5/2$243
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/274:45 pm
OMA
-
STL
Nonstop1h 15m
Southwest
Tue 6/28:50 pm
STL
-
OMA
Nonstop1h 20m
Southwest
Deal found 5/4$257
This Mytrip deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:19 pm
OMA
-
STL
1 stop23h 04m
Frontier
Mon 5/258:08 pm
STL
-
OMA
1 stop23h 16m
Frontier
Deal found 5/6$260
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/268:05 am
OMA
-
STL
Nonstop1h 15m
Southwest
Wed 5/278:25 am
STL
-
OMA
Nonstop1h 20m
Southwest
Deal found 5/4$261
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/64:45 pm
OMA
-
STL
Nonstop1h 15m
Southwest
Mon 6/89:45 pm
STL
-
OMA
Nonstop1h 15m
Southwest
Deal found 5/5$269
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/172:16 pm
DSM
-
STL
1 stop28h 37m
Multiple Airlines
Wed 6/245:06 pm
STL
-
DSM
2 stops29h 52m
Multiple Airlines
Deal found 5/3$269
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:25 pm
OMA
-
STL
1 stop3h 21m
Delta
Wed 5/273:11 pm
STL
-
OMA
1 stop4h 21m
Delta
Deal found 5/4$275
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:19 pm
OMA
-
STL
1 stop23h 04m
Frontier
Sun 6/79:06 pm
STL
-
OMA
2 stops22h 05m
Frontier
Deal found 5/2$277
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:03 am
CID
-
MCI
1 stop7h 04m
American Airlines
Tue 6/95:31 am
MCI
-
CID
1 stop6h 23m
American Airlines
Deal found 5/4$279

Find flight deals from Iowa to Missouri

Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated May 7, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$181
(Kiwi.com)

One-way from

$67
(Kiwi.com)

Popular in

July

Cheapest in

September

Average price

$203

Good round-trip deal

$105 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
Search Deals
From Iowa to Missouri
Search Deals
One-way flight from Iowa to Missouri
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($44 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals
Price to beat on a round-trip flight from Iowa to Missouri.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Cedar RapidsKansas City

CID - MCI

CIDMCI

Cedar Rapids

Tue 6/2

6:03 am-1:07 pm

1 stop7h 04m

Kansas City

Tue 6/9

5:31 am-11:54 am

1 stop6h 23m

$279

OmahaSpringfield

OMA - SGF

OMASGF

Omaha Eppley Airfield

Sun 5/31

6:00 am-10:43 am

1 stop4h 43m

Springfield-Branson

Sun 6/7

6:35 pm-11:44 pm

1 stop5h 09m

$289

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Mon 6/1

4:50 pm-11:50 pm

1 stop7h 00m

Lambert-St Louis

Thu 6/4

7:20 pm-1:55 am

1 stop6h 35m

$289

OmahaColumbia

OMA - COU

OMACOU

Omaha Eppley Airfield

Tue 5/19

6:00 am-10:55 am

1 stop4h 55m

Columbia Regional

Sat 5/23

3:25 pm-10:04 pm

1 stop6h 39m

$298

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 6/13

3:35 pm-9:45 pm

1 stop6h 10m

Lambert-St Louis

Wed 6/17

5:40 am-11:30 am

1 stop5h 50m

$298
Quickest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 8/25

6:10 am-11:20 am

1 stop5h 10m

Lambert-St Louis

Sun 8/30

7:30 pm-10:35 pm

1 stop3h 05m

$298

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 7/14

5:20 am-2:50 pm

2 stops9h 30m

Lambert-St Louis

Sat 7/18

5:40 am-11:35 am

1 stop5h 55m

$310

Cedar RapidsKansas City

CID - MCI

CIDMCI

Cedar Rapids

Mon 6/1

11:03 am-3:59 pm

1 stop4h 56m

Kansas City

Mon 6/8

5:10 pm-10:51 pm

1 stop5h 41m

$314

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 6/19

5:10 am-9:10 am

1 stop4h 00m

Lambert-St Louis

Fri 6/26

6:30 pm-11:30 pm

1 stop5h 00m

$317

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 6/20

6:55 pm-11:45 pm

1 stop4h 50m

Lambert-St Louis

Sat 6/27

4:45 pm-9:55 pm

1 stop5h 10m

$317

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/2

Showing 1-10 of 60 resultsSorted by cheapest first
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6

Best time to book a flight from Iowa to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Missouri

What is the cheapest month to book a flight from Iowa to Missouri?

Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $77). Flying from Iowa to Missouri in February is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Iowa to Missouri?

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated May 7, 2026.
Peruse reviews from past customers who have flown with Southwest and American Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,301 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

7.9

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
7.9
Good
4,301 reviews
Southwest
7.9
Good
4,301 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

7.9

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,669 reviews
Southwest
7.9
Good
4,301 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

7.9

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Iowa to Missouri flight route?

    Within the past month, 14 users have taken a look at flights from Iowa to Missouri.

  • How long is the flight from Iowa to Missouri?

    A quick flight from Iowa to Missouri can take about 4h 43m. American Airlines provides one of the quickest options available for as low as $289. The distance between Iowa and Missouri is about 311 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Iowa to Missouri one-way?

    One-way options have recently been found by users for as low as $38 on Southwest. Other airlines that offer cheap prices include United Airlines from $199 and American Airlines from $227 one-way.

  • Can I find deals for flights from Iowa to Missouri that include hotel bookings?

    Yes. In addition to deals on Iowa to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Missouri.

  • Can I find deals for business class flights from Iowa to Missouri?

    Yes. Cheapflights offers flight deals from Iowa to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Missouri?

    Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $77). Flying from Iowa to Missouri in February is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Iowa to Missouri

Discover the top 2 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$107Average$253FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$158Average$324FlexibilityNo cancel feeOn-time71%

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