Missouri

$66+ Cheap flights from Iowa to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/8. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Thg. 5 10 — Thg. 5 171
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Cheap flight deals from Iowa to Missouri

Cheapest flights from Iowa to Missouri
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Tháng Tư 10, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 3 5/268:19 pm
OMA
-
STL
2 stops12h 36m
Frontier
Th. 3 6/28:08 pm
STL
-
OMA
1 stop23h 26m
Frontier
Deal found 4/5$198
This Frontier deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 6 5/12:04 pm
DSM
-
STL
1 stop5h 17m
Frontier
CN 5/38:06 pm
STL
-
DSM
1 stop23h 32m
Frontier
Deal found 4/6$205
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 6 5/88:19 pm
OMA
-
STL
2 stops12h 36m
Frontier
Th. 7 5/98:08 pm
STL
-
OMA
1 stop23h 26m
Frontier
Deal found 4/7$256
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 4 5/64:45 pm
OMA
-
STL
Nonstop1h 15m
Southwest
Th. 4 5/138:50 pm
STL
-
OMA
Nonstop1h 20m
Southwest
Deal found 4/8$257
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 5 5/288:19 pm
OMA
-
STL
2 stops12h 36m
Frontier
Th. 4 6/38:08 pm
STL
-
OMA
1 stop23h 26m
Frontier
Deal found 4/8$258
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 7 5/162:50 pm
OMA
-
STL
Nonstop1h 15m
Southwest
Th. 4 5/208:25 am
STL
-
OMA
Nonstop1h 20m
Southwest
Deal found 4/5$263
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 4 4/292:05 pm
OMA
-
STL
1 stop7h 40m
Southwest
Th. 4 5/68:50 pm
STL
-
OMA
Nonstop1h 20m
Southwest
Deal found 4/8$267
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 7 5/26:50 am
OMA
-
STL
Nonstop1h 15m
Southwest
Th. 2 5/49:40 pm
STL
-
OMA
Nonstop1h 20m
Southwest
Deal found 4/8$269
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 4 5/65:30 am
DSM
-
STL
1 stop4h 00m
Southwest
Th. 4 5/133:55 pm
STL
-
DSM
1 stop6h 15m
Southwest
Deal found 4/6$279
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 7 5/165:35 am
DSM
-
STL
1 stop4h 55m
Southwest
Th. 4 5/205:35 am
STL
-
DSM
1 stop5h 50m
Southwest
Deal found 4/8$288
This Trip.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 2 4/202:04 pm
DSM
-
STL
1 stop5h 28m
Frontier
Th. 5 4/238:06 pm
STL
-
DSM
1 stop17h 03m
Frontier
Deal found 4/6$291
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Th. 2 5/44:20 pm
DSM
-
STL
1 stop6h 25m
Southwest
Th. 2 5/114:40 pm
STL
-
DSM
1 stop6h 25m
Southwest
Deal found 4/6$297

Find flight deals from Iowa to Missouri

Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated Tháng Tư 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$198
(Kiwi.com)

One-way from

$66
(Kiwi.com)

Popular in

July

Cheapest in

September

Average price

$299

Good round-trip deal

$105 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
From Iowa to Missouri
One-way flight from Iowa to Missouri
Highest demand for flights based on searches. 13% potential increase in price ($46 potential increase over avg. RT price).
Cheapest flight prices on average. 8% potential price decrease ($26 potential savings vs. average RT price).
Average for round-trip flights in April 2026
Price to beat on a round-trip flight from Iowa to Missouri.

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Tháng Tư 10, 2026.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Th. 4 5/6

4:45 pm-6:00 pm

Nonstop1h 15m

Lambert-St Louis

Th. 4 5/13

8:50 pm-10:10 pm

Nonstop1h 20m

$257

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Th. 7 5/16

2:50 pm-4:05 pm

Nonstop1h 15m

Lambert-St Louis

Th. 4 5/20

8:25 am-9:45 am

Nonstop1h 20m

$263

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Th. 5 5/28

5:40 pm-6:55 pm

Nonstop1h 15m

Lambert-St Louis

Th. 4 6/3

8:25 am-9:45 am

Nonstop1h 20m

$263

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Th. 7 5/2

6:50 am-8:05 am

Nonstop1h 15m

Lambert-St Louis

Th. 7 5/2

10:35 am-11:55 am

Nonstop1h 20m

$269

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Th. 7 5/2

2:50 pm-4:05 pm

Nonstop1h 15m

Lambert-St Louis

Th. 2 5/4

7:20 am-1:20 pm

1 stop6h 00m

$279

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Th. 6 5/1

10:21 am-6:50 am

2 stops20h 29m

Lambert-St Louis

Th. 7 5/2

8:17 pm-8:13 pm

1 stop23h 56m

$293

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Th. 5 5/21

4:20 pm-10:45 pm

1 stop6h 25m

Lambert-St Louis

Th. 5 5/28

5:40 am-11:45 am

1 stop6h 05m

$297

OmahaColumbia

OMA - COU

OMACOU

Omaha Eppley Airfield

Th. 5 4/23

5:17 am-11:35 am

1 stop6h 18m

Columbia Regional

Th. 2 4/27

5:21 pm-11:32 pm

1 stop6h 11m

$298

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

CN 5/31

8:15 pm-12:19 am

1 stop4h 04m

Lambert-St Louis

Th. 4 6/10

6:00 am-10:27 am

1 stop4h 27m

$298

Cedar RapidsKansas City

CID - MCI

CIDMCI

Cedar Rapids

Th. 6 5/8

6:41 pm-11:31 pm

1 stop4h 50m

Kansas City

Th. 6 5/15

6:17 am-10:27 am

1 stop4h 10m

$299

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/9

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Iowa to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Missouri

What is the cheapest month to book a flight from Iowa to Missouri?

Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $93). Flying from Iowa to Missouri in January is currently the most expensive (average of $275). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Iowa to Missouri?

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated Tháng Tư 10, 2026.
Peruse reviews from past customers who have flown with Southwest,United Airlines, andAmerican Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How popular is this Iowa to Missouri flight route?

  • How long is the flight from Iowa to Missouri?

    A quick flight from Iowa to Missouri can take about 1h 15m. Southwest provides one of the quickest options available for as low as $257. The distance between Iowa and Missouri is about 341 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Iowa to Missouri that include hotel bookings?

    Yes. In addition to deals on Iowa to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Missouri.

  • Can I find deals for business class flights from Iowa to Missouri?

    Yes. Cheapflights offers flight deals from Iowa to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Missouri?

    Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $93). Flying from Iowa to Missouri in January is currently the most expensive (average of $275). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to Missouri

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Iowa to Missouri

Discover the top 3 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Tháng Tư 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$107Average$253FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$218Average$418FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$297FlexibilityNo cancel feeOn-time71%

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