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$61+ Cheap flights from Iowa to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/9. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
ene. 3 — ene. 101
sáb. 1/3
sáb. 1/10
1 adult, Economy
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Cheap flight deals from Iowa to Missouri

Cheapest flights from Iowa to Missouri
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 4, 2025.

This Frontier deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/148:12 pmCID - MCI
1 stop23h 38mFrontier
mar. 12/238:45 pmMCI - CID
1 stop22h 08mFrontier
Deal found 12/3$233
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/175:00 amOMA - SGF
1 stop4h 46mAmerican Airlines
dom. 12/218:29 amSGF - OMA
1 stop6h 16mAmerican Airlines
Deal found 12/1$259
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/117:20 amCID - MCI
1 stop6h 42mAmerican Airlines
dom. 12/145:13 amMCI - CID
1 stop7h 30mAmerican Airlines
Deal found 12/3$269
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/307:31 pmOMA - SGF
1 stop4h 25mAmerican Airlines
mar. 1/65:00 pmSGF - OMA
1 stop5h 56mAmerican Airlines
Deal found 12/2$274
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/187:31 pmOMA - SGF
1 stop4h 25mAmerican Airlines
lun. 12/226:00 pmSGF - OMA
1 stop4h 59mAmerican Airlines
Deal found 12/3$289
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/316:40 amDSM - STL
1 stop6h 56mAmerican Airlines
mié. 1/711:05 amSTL - DSM
1 stop5h 19mAmerican Airlines
Deal found 12/2$290
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/113:44 pmDSM - MCI
1 stop17h 03mAllegiant Air
dom. 12/144:35 pmMCI - DSM
1 stop30h 37mAllegiant Air
Deal found 12/2$296
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/312:12 pmOMA - STL
1 stop18h 23mAmerican Airlines
mié. 1/711:55 amSTL - OMA
1 stop4h 41mAmerican Airlines
Deal found 12/2$297
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/148:58 amCID - MCI
1 stop6h 47mMultiple Airlines
jue. 12/1811:53 amMCI - CID
1 stop22h 37mMultiple Airlines
Deal found 12/2$305
This Delta deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/315:55 pmDSM - STL
1 stop4h 21mDelta
mié. 1/76:35 amSTL - DSM
2 stops9h 06mDelta
Deal found 12/2$309
This Kiwi.com deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/118:30 amDSM - STL
1 stop27h 42mMultiple Airlines
dom. 12/143:30 pmSTL - DSM
2 stops23h 28mMultiple Airlines
Deal found 12/1$316
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/43:25 pmOMA - COU
1 stop5h 57mUnited Airlines
lun. 12/89:00 amCOU - OMA
1 stop7h 22mUnited Airlines
Deal found 12/2$338

Find flight deals from Iowa to Missouri

Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated diciembre 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$179
(Kiwi.com)

One-way from

$61
(Trip.com)

Popular in

November

Cheapest in

September

Average price

$330

Good round-trip deal

$105 or less

Good one-way deal

$186 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
Search Deals
From Iowa to Missouri
Search Deals
One-way flight from Iowa to Missouri
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($54 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($27 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Iowa to Missouri.
Search Deals
Price to beat on a one-way flight from Iowa to Missouri.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 4, 2025.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.

Fly from

Iowa

Fly to

Missouri

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

sáb. 1/10

6:45 am-8:00 am

Nonstop1h 15m

Lambert-St Louis

mar. 1/13

10:15 am-11:25 am

Nonstop1h 10m

$210

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

jue. 1/8

1:11 pm-10:02 am

1 stop20h 51m

Lambert-St Louis

dom. 1/11

9:46 pm-11:41 am

1 stop13h 55m

$214

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

mar. 2/17

5:24 am-11:02 am

1 stop5h 38m

Lambert-St Louis

sáb. 2/21

10:12 am-4:57 pm

1 stop6h 45m

$217

WaterlooSt. Louis

ALO - STL

ALOSTL

Waterloo

vie. 1/30

6:00 am-10:20 am

1 stop4h 20m

Lambert-St Louis

lun. 2/2

11:05 am-2:53 pm

1 stop3h 48m

$219

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

mié. 1/14

10:59 am-8:43 pm

2 stops9h 44m

Lambert-St Louis

sáb. 1/17

3:40 pm-9:24 pm

1 stop5h 44m

$222

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

jue. 1/22

9:40 am-4:14 pm

1 stop6h 34m

Lambert-St Louis

lun. 1/26

6:44 pm-11:33 am

1 stop16h 49m

$232

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

vie. 1/9

3:20 pm-4:35 pm

Nonstop1h 15m

Lambert-St Louis

mar. 1/13

10:15 am-11:25 am

Nonstop1h 10m

$240

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

mié. 1/7

3:20 pm-4:35 pm

Nonstop1h 15m

Lambert-St Louis

vie. 1/9

10:15 am-11:25 am

Nonstop1h 10m

$240

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

vie. 1/9

8:00 am-2:30 pm

1 stop6h 30m

Lambert-St Louis

mar. 1/13

9:57 am-2:33 pm

1 stop4h 36m

$245

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

mié. 1/7

10:59 am-3:00 pm

1 stop4h 01m

Lambert-St Louis

vie. 1/9

6:35 am-11:23 am

1 stop4h 48m

$245

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/4

Showing 1-10 of 59 results
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Best time to book a flight from Iowa to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Missouri

What is the cheapest month to book a flight from Iowa to Missouri?

Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $93). Flying from Iowa to Missouri in February is currently the most expensive (average of $224). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to MO?

Find hourly flight availability from Iowa to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 4, 2025.

It’s optimal to fly from Iowa to Missouri in the evening. By choosing this option you can save up to 24% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated diciembre 4, 2025.
Peruse reviews from past customers who have flown with Southwest, United Airlines, and American Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,251 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,251 reviews
Southwest
8.0
Very good
4,251 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,066 reviews
Southwest
8.0
Very good
4,251 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,047 reviews
Southwest
8.0
Very good
4,251 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southern / Mokulele
6.4
Okay
27 reviews
Southwest
8.0
Very good
4,251 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Iowa to Missouri flight route?

    Within the past month, 32 users have taken a look at flights from Iowa to Missouri.

  • How long is the flight from Iowa to Missouri?

    A quick flight from Iowa to Missouri can take about 1h 15m. Southwest provides one of the quickest options available for as low as $210. The distance between Iowa and Missouri is about 259 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Iowa to Missouri that include hotel bookings?

    Yes. In addition to deals on Iowa to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Missouri.

  • Can I find deals for business class flights from Iowa to Missouri?

    Yes. Cheapflights offers flight deals from Iowa to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Missouri?

    Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $93). Flying from Iowa to Missouri in February is currently the most expensive (average of $224). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to Missouri

Discover the top 4 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
Southern / MokuleleCheapest$61Average$85FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$97Average$280FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$218Average$300FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$218Average$418FlexibilityNo cancel feeOn-time69%

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