Missouri

$82+ Cheap flights from Iowa to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/17. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Apr 20 — Apr 271
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Cheap flight deals from Iowa to Missouri

Cheapest flights from Iowa to Missouri
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 21, 2026.

This Booking.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:36 pm
CID
-
MCI
1 stop23h 30m
Frontier
Mon 5/112:34 pm
MCI
-
CID
1 stop22h 32m
Frontier
Deal found 3/15$191
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:49 pm
OMA
-
STL
1 stop22h 43m
Frontier
Sat 4/258:17 pm
STL
-
OMA
1 stop23h 56m
Frontier
Deal found 3/19$197
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:49 pm
OMA
-
STL
1 stop22h 43m
Frontier
Thu 4/238:06 pm
STL
-
OMA
1 stop23h 58m
Frontier
Deal found 3/19$202
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:19 pm
OMA
-
STL
2 stops12h 36m
Frontier
Mon 5/118:08 pm
STL
-
OMA
1 stop23h 16m
Frontier
Deal found 3/18$235
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:59 pm
OMA
-
STL
2 stops33h 51m
Frontier
Sat 4/258:17 pm
STL
-
OMA
1 stop23h 56m
Frontier
Deal found 3/19$239
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:59 pm
OMA
-
STL
2 stops33h 51m
Frontier
Thu 4/238:06 pm
STL
-
OMA
1 stop23h 58m
Frontier
Deal found 3/19$244
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:58 pm
OMA
-
STL
1 stop22h 23m
Frontier
Sat 4/258:17 pm
STL
-
OMA
1 stop23h 56m
Frontier
Deal found 3/19$272
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:58 pm
OMA
-
STL
1 stop22h 23m
Frontier
Thu 4/238:06 pm
STL
-
OMA
1 stop23h 58m
Frontier
Deal found 3/19$277
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:58 pm
OMA
-
COU
1 stop4h 02m
American Airlines
Sat 4/46:00 am
COU
-
OMA
1 stop6h 40m
American Airlines
Deal found 3/16$278
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/139:07 pm
DSM
-
STL
2 stops21h 29m
Multiple Airlines
Thu 4/238:06 pm
STL
-
DSM
1 stop17h 03m
Multiple Airlines
Deal found 3/19$278
This Delta deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:31 pm
DSM
-
STL
1 stop5h 05m
Delta
Tue 4/217:25 am
STL
-
DSM
1 stop6h 30m
Delta
Deal found 3/19$279
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/128:59 pm
OMA
-
STL
1 stop12h 49m
Frontier
Sat 4/258:17 pm
STL
-
OMA
1 stop23h 56m
Frontier
Deal found 3/19$281

Find flight deals from Iowa to Missouri

Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated March 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$197
(Kiwi.com)

One-way from

$82
(Kiwi.com)

Popular in

July

Cheapest in

September

Average price

$243

Good round-trip deal

$105 or less

Good one-way deal

$242 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
From Iowa to Missouri
One-way flight from Iowa to Missouri
Highest demand for flights based on searches. 16% potential increase in price ($58 potential increase over avg. RT price).
Cheapest flight prices on average. 9% potential price decrease ($28 potential savings vs. average RT price).
Average for round-trip flights in March 2026
Price to beat on a round-trip flight from Iowa to Missouri.
Price to beat on a one-way flight from Iowa to Missouri.

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 21, 2026.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

OmahaColumbia

OMA - COU

OMACOU

Omaha Eppley Airfield

Tue 3/31

1:58 pm-6:00 pm

1 stop4h 02m

Columbia Regional

Sat 4/4

6:00 am-12:40 pm

1 stop6h 40m

$278

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 4/15

6:55 am-1:00 pm

2 stops6h 05m

Lambert-St Louis

Wed 4/22

6:35 am-2:05 pm

1 stop7h 30m

$284

Cedar RapidsKansas City

CID - MCI

CIDMCI

Cedar Rapids

Tue 3/31

5:00 am-8:42 am

1 stop3h 42m

Kansas City

Sat 4/4

6:40 am-12:37 pm

1 stop5h 57m

$289

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 4/13

4:23 pm-11:14 pm

1 stop6h 51m

Lambert-St Louis

Tue 4/21

12:23 pm-3:41 pm

1 stop3h 18m

$293

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 5/12

5:30 am-11:30 am

1 stop6h 00m

Lambert-St Louis

Sat 5/16

5:40 am-11:30 am

1 stop5h 50m

$293

OmahaColumbia

OMA - COU

OMACOU

Omaha Eppley Airfield

Wed 4/1

5:05 pm-10:01 pm

1 stop4h 56m

Columbia Regional

Sun 4/5

3:23 pm-10:11 pm

1 stop6h 48m

$298

OmahaColumbia

OMA - COU

OMACOU

Omaha Eppley Airfield

Fri 4/3

5:05 pm-12:33 am

1 stop7h 28m

Columbia Regional

Tue 4/7

11:30 am-3:39 pm

1 stop4h 09m

$298

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 4/14

6:10 am-3:32 pm

2 stops9h 22m

Lambert-St Louis

Mon 4/20

12:23 pm-3:41 pm

1 stop3h 18m

$298

OmahaColumbia

OMA - COU

OMACOU

Omaha Eppley Airfield

Wed 4/1

12:16 pm-6:00 pm

1 stop5h 44m

Columbia Regional

Sun 4/5

6:00 am-11:45 am

1 stop5h 45m

$298

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 4/14

4:23 pm-11:14 pm

1 stop6h 51m

Lambert-St Louis

Fri 4/24

5:35 pm-9:12 pm

1 stop3h 37m

$298

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/18

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Iowa to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Missouri

What is the cheapest month to book a flight from Iowa to Missouri?

Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $93). Flying from Iowa to Missouri in January is currently the most expensive (average of $275). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated March 21, 2026.
Peruse reviews from past customers who have flown with Southwest,United Airlines, andAmerican Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How popular is this Iowa to Missouri flight route?

  • How long is the flight from Iowa to Missouri?

    A quick flight from Iowa to Missouri can take about 4h 02m. American Airlines provides one of the quickest options available for as low as $278. The distance between Iowa and Missouri is about 259 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Iowa to Missouri that include hotel bookings?

    Yes. In addition to deals on Iowa to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Missouri.

  • Can I find deals for business class flights from Iowa to Missouri?

    Yes. Cheapflights offers flight deals from Iowa to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Missouri?

    Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $93). Flying from Iowa to Missouri in January is currently the most expensive (average of $275). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to Missouri

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Iowa to Missouri

Discover the top 3 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$107Average$250FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$218Average$394FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$297FlexibilityNo cancel feeOn-time71%

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