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Missouri

$71+ Cheap flights from Iowa to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Iowa to Missouri

Cheapest flights from Iowa to Missouri
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/243:20 pm
DSM
-
STL
Nonstop1h 15m
Southwest
Tue 3/38:00 pm
STL
-
DSM
Nonstop1h 10m
Southwest
Deal found 1/27$97
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/101:55 pm
DSM
-
STL
1 stop7h 40m
Southwest
Wed 3/114:00 pm
STL
-
DSM
1 stop6h 05m
Southwest
Deal found 1/27$117
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2410:57 am
DSM
-
STL
1 stop5h 48m
Delta
Tue 3/36:00 am
STL
-
DSM
1 stop5h 19m
Delta
Deal found 1/27$157
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/185:15 pm
DSM
-
STL
1 stop6h 21m
Delta
Sat 2/216:10 am
STL
-
DSM
1 stop4h 07m
Delta
Deal found 1/26$191
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/16:15 pm
DSM
-
STL
Nonstop1h 05m
Southwest
Tue 3/310:15 am
STL
-
DSM
Nonstop1h 10m
Southwest
Deal found 1/27$213
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/269:03 pm
OMA
-
STL
1 stop12h 46m
Frontier
Sat 3/288:12 pm
STL
-
OMA
1 stop24h 06m
Frontier
Deal found 1/27$235
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/108:00 am
OMA
-
COU
1 stop6h 35m
United Airlines
Sat 2/1411:15 am
COU
-
OMA
1 stop6h 33m
United Airlines
Deal found 1/26$238
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/64:19 pm
CID
-
MCI
1 stop6h 41m
Delta
Sun 3/86:07 am
MCI
-
CID
1 stop5h 04m
Delta
Deal found 1/26$239
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/225:40 am
OMA
-
SGF
1 stop4h 28m
American Airlines
Sun 3/17:34 am
SGF
-
OMA
1 stop4h 12m
American Airlines
Deal found 1/27$249
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/114:16 pm
CID
-
MCI
1 stop6h 23m
American Airlines
Sun 2/155:00 am
MCI
-
CID
1 stop4h 18m
American Airlines
Deal found 1/27$249
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/56:41 pm
CID
-
MCI
1 stop3h 58m
American Airlines
Thu 2/125:00 am
MCI
-
CID
1 stop4h 18m
American Airlines
Deal found 1/27$259
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/13:24 pm
DSM
-
STL
1 stop5h 41m
United Airlines
Tue 3/39:55 am
STL
-
DSM
1 stop4h 32m
United Airlines
Deal found 1/27$259

Find flight deals from Iowa to Missouri

Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$117
(Southwest)

One-way from

$86
(Southwest)

Popular in

July

Cheapest in

September

Average price

$467

Good round-trip deal

$105 or less

Good one-way deal

$187 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
Search Deals
From Iowa to Missouri
Search Deals
One-way flight from Iowa to Missouri
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($29 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Iowa to Missouri.
Search Deals
Price to beat on a one-way flight from Iowa to Missouri.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.

Fly from

Iowa

Fly to

Missouri

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 2/24

3:20 pm-4:35 pm

Nonstop1h 15m

Lambert-St Louis

Tue 3/3

8:00 pm-9:10 pm

Nonstop1h 10m

$97

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/10

1:55 pm-9:35 pm

1 stop7h 40m

Lambert-St Louis

Wed 3/11

4:00 pm-10:05 pm

1 stop6h 05m

$117

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 2/24

10:57 am-8:43 pm

2 stops9h 46m

Lambert-St Louis

Tue 3/3

3:40 pm-9:20 pm

1 stop5h 40m

$162

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 2/23

5:00 am-10:03 am

1 stop5h 03m

Lambert-St Louis

Mon 3/2

6:36 pm-11:40 pm

1 stop5h 04m

$191

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 2/18

5:15 pm-11:36 pm

1 stop6h 21m

Lambert-St Louis

Mon 2/23

6:10 am-10:17 am

1 stop4h 07m

$191

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 2/23

5:15 pm-11:36 pm

1 stop6h 21m

Lambert-St Louis

Mon 3/2

5:29 pm-9:20 pm

1 stop3h 51m

$191

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sun 3/1

6:10 am-2:15 pm

1 stop8h 05m

Lambert-St Louis

Tue 3/3

10:15 am-11:25 am

Nonstop1h 10m

$213

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Thu 3/26

9:03 pm-9:49 am

1 stop12h 46m

Lambert-St Louis

Sat 3/28

8:12 pm-8:18 pm

1 stop24h 06m

$235

OmahaColumbia

OMA - COU

OMACOU

Omaha Eppley Airfield

Tue 2/10

8:00 am-2:35 pm

1 stop6h 35m

Columbia Regional

Sat 2/14

11:15 am-5:48 pm

1 stop6h 33m

$238

Cedar RapidsKansas City

CID - MCI

CIDMCI

Cedar Rapids

Fri 3/6

4:19 pm-11:00 pm

1 stop6h 41m

Kansas City

Sun 3/8

6:07 am-11:11 am

1 stop5h 04m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 60 results
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Best time to book a flight from Iowa to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Missouri

What is the cheapest month to book a flight from Iowa to Missouri?

Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $93). Flying from Iowa to Missouri in February is currently the most expensive (average of $253). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to MO?

Find hourly flight availability from Iowa to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 27, 2026.

When flying from Iowa to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated January 27, 2026.
Peruse reviews from past customers who have flown with Southwest, United Airlines, and American Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,268 reviews

Overall

8.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,268 reviews
Southwest
8.0
Very good
4,268 reviews

Overall

8.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,206 reviews
Southwest
8.0
Very good
4,268 reviews

Overall

8.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,198 reviews
Southwest
8.0
Very good
4,268 reviews

Overall

8.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Iowa to Missouri flight route?

    Within the past month, 28 users have taken a look at flights from Iowa to Missouri.

  • How long is the flight from Iowa to Missouri?

    A quick flight from Iowa to Missouri can take about 6h 21m. Delta provides one of the quickest options available for as low as $191. The distance between Iowa and Missouri is about 259 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Iowa to Missouri that include hotel bookings?

    Yes. In addition to deals on Iowa to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Missouri.

  • Can I find deals for business class flights from Iowa to Missouri?

    Yes. Cheapflights offers flight deals from Iowa to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Missouri?

    Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $93). Flying from Iowa to Missouri in February is currently the most expensive (average of $253). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Iowa to Missouri

Discover the top 3 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$97Average$253FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$218Average$418FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$295FlexibilityNo cancel feeOn-time71%

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