Missouri

$76+ Cheap flights from Iowa to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
May 22 — May 291
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Cheap flight deals from Iowa to Missouri

Cheapest flights from Iowa to Missouri
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2026.

This Frontier deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
-
STL
1 stop5h 07m
Frontier
Thu 6/48:08 pm
STL
-
DSM
1 stop17h 23m
Frontier
Deal found 4/19$181
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:15 am
DSM
-
STL
1 stop6h 55m
Delta
Tue 5/266:21 am
STL
-
DSM
1 stop3h 55m
Delta
Deal found 4/21$212
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:27 am
DSM
-
STL
1 stop6h 55m
Delta
Wed 5/138:53 am
STL
-
DSM
1 stop3h 31m
Delta
Deal found 4/22$215
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:30 pm
DSM
-
STL
1 stop4h 40m
Southwest
Wed 5/133:10 pm
STL
-
DSM
2 stops7h 00m
Southwest
Deal found 4/22$221
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:41 pm
DSM
-
STL
1 stop5h 18m
Delta
Mon 5/186:21 am
STL
-
DSM
1 stop3h 55m
Delta
Deal found 4/21$255
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1912:35 pm
OMA
-
STL
1 stop7h 40m
Southwest
Tue 5/268:50 pm
STL
-
OMA
Nonstop1h 20m
Southwest
Deal found 4/20$258
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:34 am
OMA
-
STL
1 stop3h 58m
Delta
Tue 5/265:36 pm
STL
-
OMA
1 stop5h 20m
Delta
Deal found 4/20$261
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:30 am
DSM
-
STL
1 stop4h 00m
Southwest
Mon 5/255:40 am
STL
-
DSM
1 stop6h 05m
Southwest
Deal found 4/22$266
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:19 pm
OMA
-
STL
2 stops12h 36m
Frontier
Mon 6/18:08 pm
STL
-
OMA
1 stop23h 16m
Frontier
Deal found 4/21$276
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:11 am
DSM
-
STL
1 stop5h 30m
American Airlines
Fri 5/155:51 am
STL
-
DSM
1 stop4h 40m
American Airlines
Deal found 4/22$276
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:00 am
DSM
-
STL
1 stop6h 11m
United Airlines
Wed 6/35:10 am
STL
-
DSM
1 stop5h 32m
United Airlines
Deal found 4/20$279
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:34 pm
OMA
-
STL
1 stop4h 20m
American Airlines
Tue 5/266:12 pm
STL
-
OMA
1 stop6h 10m
American Airlines
Deal found 4/22$280

Find flight deals from Iowa to Missouri

Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated April 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$181
(Frontier)

One-way from

$76
(Kiwi.com)

Popular in

July

Cheapest in

May

Average price

$328

Good round-trip deal

$105 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
From Iowa to Missouri
One-way flight from Iowa to Missouri
Highest demand for flights based on searches. 13% potential increase in price ($47 potential increase over avg. RT price).
Cheapest flight prices on average. 9% potential price decrease ($27 potential savings vs. average RT price).
Average for round-trip flights in April 2026
Price to beat on a round-trip flight from Iowa to Missouri.

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 5/12

5:27 am-12:22 pm

1 stop6h 55m

Lambert-St Louis

Wed 5/13

8:53 am-12:24 pm

1 stop3h 31m

$215

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Tue 5/19

12:35 pm-8:15 pm

1 stop7h 40m

Lambert-St Louis

Tue 5/26

8:50 pm-10:10 pm

Nonstop1h 20m

$258

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 6/2

6:00 am-12:11 pm

1 stop6h 11m

Lambert-St Louis

Wed 6/3

5:10 am-10:42 am

1 stop5h 32m

$279

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 5/19

5:30 am-9:30 am

1 stop4h 00m

Lambert-St Louis

Tue 5/26

2:30 pm-10:10 pm

2 stops7h 40m

$285

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 6/6

6:55 pm-11:45 pm

1 stop4h 50m

Lambert-St Louis

Sat 6/13

4:45 pm-9:55 pm

1 stop5h 10m

$287

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 6/1

4:20 pm-10:45 pm

1 stop6h 25m

Lambert-St Louis

Mon 6/8

6:30 pm-11:30 pm

1 stop5h 00m

$297

Cedar RapidsKansas City

CID - MCI

CIDMCI

Cedar Rapids

Tue 5/19

8:00 am-2:26 pm

1 stop6h 26m

Kansas City

Tue 5/26

5:00 pm-9:36 pm

1 stop4h 36m

$299

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Tue 5/5

5:40 am-11:47 am

1 stop6h 07m

Lambert-St Louis

Sat 5/9

5:51 am-9:24 am

1 stop3h 33m

$308

Cedar RapidsKansas City

CID - MCI

CIDMCI

Cedar Rapids

Tue 5/5

4:22 pm-11:01 pm

1 stop6h 39m

Kansas City

Sat 5/9

6:19 am-11:16 am

1 stop4h 57m

$309

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 7/2

5:00 am-10:34 am

1 stop5h 34m

Lambert-St Louis

Sun 7/5

8:35 pm-12:45 am

1 stop4h 10m

$317

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Iowa to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Missouri

What is the cheapest month to book a flight from Iowa to Missouri?

Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $77). Flying from Iowa to Missouri in February is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Iowa to Missouri?

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated April 22, 2026.
Peruse reviews from past customers who have flown with Southwest,United Airlines, andAmerican Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How popular is this Iowa to Missouri flight route?

  • How long is the flight from Iowa to Missouri?

    A quick flight from Iowa to Missouri can take about 6h 11m. Delta provides one of the quickest options available for as low as $279. The distance between Iowa and Missouri is about 259 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Iowa to Missouri that include hotel bookings?

    Yes. In addition to deals on Iowa to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Missouri.

  • Can I find deals for business class flights from Iowa to Missouri?

    Yes. Cheapflights offers flight deals from Iowa to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Missouri?

    Currently, October is the cheapest month in which you can book a flight from Iowa to Missouri (average of $77). Flying from Iowa to Missouri in February is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to Missouri

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Iowa to Missouri

Discover the top 3 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$107Average$250FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$158Average$327FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$218Average$383FlexibilityNo cancel feeOn-time69%

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