$66+ Cheap flights from Iowa to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
May 3 — May 101
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to Missouri with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Iowa to MissouriExplore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2026.
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:19 pm
OMA
- STL
1 stop23h 04m
Frontier
Fri 6/58:08 pm
STL
- OMA
1 stop23h 26m
Frontier
Deal found 3/31![Frontier logo]()
$256
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:10 pm
OMA
- STL
Nonstop1h 15m
Southwest
Tue 6/238:35 am
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 3/31![Southwest logo]()
$257
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:40 pm
OMA
- STL
Nonstop1h 15m
Southwest
Wed 5/68:25 am
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 4/2![Southwest logo]()
$263
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:50 pm
OMA
- STL
Nonstop1h 15m
Southwest
Sat 5/910:35 am
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 4/1![Southwest logo]()
$269
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:21 pm
OMA
- STL
1 stop5h 52m
Delta
Wed 5/65:35 pm
STL
- OMA
1 stop3h 47m
Delta
Deal found 4/2![Delta logo]()
$273
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:34 am
OMA
- STL
1 stop3h 58m
Delta
Mon 5/115:36 pm
STL
- OMA
1 stop5h 20m
Delta
Deal found 3/31![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:30 am
DSM
- STL
1 stop6h 00m
Southwest
Wed 5/63:55 pm
STL
- DSM
1 stop5h 20m
Southwest
Deal found 4/1![Southwest logo]()
$279
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:20 am
OMA
- STL
Nonstop1h 15m
Southwest
Mon 4/273:50 pm
STL
- OMA
2 stops9h 10m
Southwest
Deal found 4/1![Southwest logo]()
$284
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:00 am
OMA
- COU
1 stop4h 30m
United Airlines
Sat 8/226:30 pm
COU
- OMA
1 stop6h 15m
United Airlines
Deal found 3/31![United Airlines logo]()
$288
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:30 am
DSM
- STL
1 stop6h 00m
Southwest
Sat 4/255:40 am
STL
- DSM
1 stop5h 50m
Southwest
Deal found 3/31![Southwest logo]()
$288
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:20 pm
OMA
- STL
1 stop4h 30m
Southwest
Mon 6/18:25 am
STL
- OMA
1 stop4h 30m
Southwest
Deal found 4/1![Southwest logo]()
$289
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/164:00 pm
DSM
- STL
1 stop5h 29m
Delta
Sat 5/235:36 pm
STL
- DSM
1 stop3h 27m
Delta
Deal found 3/31![Delta logo]()
$297
Best flights from Iowa to MissouriDiscover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 3, 2026.
Discover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 3, 2026.
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:21 pm
OMA
- STL
1 stop5h 52m
Delta
Wed 5/65:35 pm
STL
- OMA
1 stop3h 47m
Delta
Deal found 4/2![Delta logo]()
$273
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:40 pm
OMA
- STL
Nonstop1h 15m
Southwest
Wed 5/68:35 am
STL
- OMA
1 stop4h 40m
Southwest
Deal found 4/2![Southwest logo]()
$273
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:25 pm
OMA
- STL
1 stop4h 19m
United Airlines
Thu 6/46:00 am
STL
- OMA
1 stop4h 27m
United Airlines
Deal found 3/31![United Airlines logo]()
$273
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:35 pm
OMA
- STL
1 stop4h 11m
American Airlines
Mon 4/279:10 am
STL
- OMA
1 stop7h 12m
American Airlines
Deal found 3/29![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1312:34 pm
OMA
- MCI
1 stop28h 35m
Multiple Airlines
Fri 4/172:15 pm
MCI
- OMA
1 stop5h 49m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$406
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:20 pm
OMA
- STL
1 stop4h 30m
Southwest
Mon 4/279:40 pm
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 3/29![Southwest logo]()
$279
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:00 am
OMA
- COU
1 stop4h 30m
United Airlines
Sat 8/226:30 pm
COU
- OMA
1 stop6h 15m
United Airlines
Deal found 3/31![United Airlines logo]()
$288
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/164:00 pm
DSM
- STL
1 stop5h 29m
Delta
Sat 5/235:36 pm
STL
- DSM
1 stop3h 27m
Delta
Deal found 4/3![Delta logo]()
$297
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:37 pm
LSE
- MCI
1 stop5h 22m
American Airlines
Fri 5/85:35 am
MCI
- LSE
1 stop3h 49m
American Airlines
Deal found 4/1![American Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:30 am
DSM
- STL
1 stop6h 00m
Southwest
Wed 5/63:55 pm
STL
- DSM
1 stop5h 20m
Southwest
Deal found 4/1![Southwest logo]()
$279
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:00 pm
OMA
- COU
1 stop5h 33m
United Airlines
Mon 4/203:23 pm
COU
- OMA
1 stop6h 39m
United Airlines
Deal found 4/1![United Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:37 pm
LSE
- MCI
1 stop4h 20m
American Airlines
Wed 4/227:50 pm
MCI
- LSE
1 stop4h 04m
American Airlines
Deal found 3/30![American Airlines logo]()
$303
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:55 am
DSM
- STL
1 stop6h 55m
Southwest
Thu 5/75:40 am
STL
- DSM
1 stop6h 05m
Southwest
Deal found 4/1![Southwest logo]()
$288
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:41 pm
DSM
- STL
1 stop5h 18m
Delta
Sun 5/316:21 am
STL
- DSM
1 stop6h 03m
Delta
Deal found 3/31![Delta logo]()
$317
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/175:05 pm
OMA
- COU
1 stop4h 56m
United Airlines
Tue 4/215:00 am
COU
- OMA
1 stop5h 32m
United Airlines
Deal found 4/2![United Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:05 am
LSE
- STL
1 stop5h 55m
American Airlines
Sat 4/185:21 pm
STL
- LSE
1 stop6h 33m
American Airlines
Deal found 3/29![American Airlines logo]()
$308
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:55 am
OMA
- STL
1 stop4h 37m
Delta
Mon 5/45:35 pm
STL
- OMA
1 stop5h 14m
Delta
Deal found 3/31![Delta logo]()
$335
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/284:02 pm
OMA
- SGF
1 stop5h 03m
American Airlines
Tue 5/56:05 pm
SGF
- OMA
1 stop5h 54m
American Airlines
Deal found 4/3![American Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:30 am
DSM
- STL
2 stops7h 20m
Southwest
Sun 5/175:25 am
STL
- DSM
1 stop6h 00m
Southwest
Deal found 3/29![Southwest logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:01 pm
OMA
- MCI
1 stop15h 28m
Multiple Airlines
Sun 5/107:03 pm
MCI
- OMA
2 stops24h 31m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$420
This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:05 am
OMA
- SGF
1 stop6h 44m
United Airlines
Wed 4/221:33 pm
SGF
- OMA
1 stop6h 54m
United Airlines
Deal found 4/3![United Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:05 am
LSE
- STL
2 stops9h 25m
American Airlines
Sun 4/198:03 pm
STL
- LSE
1 stop3h 51m
American Airlines
Deal found 3/30![American Airlines logo]()
$314
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:20 am
DSM
- STL
2 stops9h 15m
Southwest
Sun 5/246:50 am
STL
- DSM
1 stop5h 45m
Southwest
Deal found 4/2![Southwest logo]()
$322
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:49 pm
OMA
- STL
1 stop4h 01m
United Airlines
Mon 5/255:41 pm
STL
- OMA
1 stop4h 18m
United Airlines
Deal found 3/29![United Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:35 pm
LSE
- STL
1 stop6h 21m
American Airlines
Mon 7/137:00 am
STL
- LSE
1 stop4h 15m
American Airlines
Deal found 3/30![American Airlines logo]()
$323
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:10 pm
OMA
- STL
1 stop5h 45m
Southwest
Wed 6/249:20 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 4/1![Southwest logo]()
$324
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:31 am
OMA
- STL
1 stop5h 08m
United Airlines
Wed 5/67:45 am
STL
- OMA
1 stop6h 36m
United Airlines
Deal found 4/2![United Airlines logo]()
$337
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:45 pm
CID
- MCI
1 stop16h 44m
Multiple Airlines
Mon 4/135:45 am
MCI
- CID
2 stops12h 10m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$517
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:40 pm
OMA
- STL
Nonstop1h 15m
Southwest
Fri 6/59:45 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 3/31![Southwest logo]()
$330
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/101:28 pm
CID
- MCI
1 stop6h 17m
United Airlines
Mon 4/138:00 am
MCI
- CID
1 stop4h 47m
United Airlines
Deal found 4/2![United Airlines logo]()
$349
Last-minute flights from Iowa to MissouriDiscover last-minute flight deals from Iowa to Missouri. Data last updated April 3, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to Missouri. Data last updated April 3, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:37 pm
LSE
- MCI
1 stop4h 20m
American Airlines
Wed 4/227:50 pm
MCI
- LSE
1 stop4h 04m
American Airlines
Deal found 3/30![American Airlines logo]()
$303
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:00 pm
OMA
- COU
1 stop5h 33m
United Airlines
Mon 4/203:23 pm
COU
- OMA
1 stop6h 39m
United Airlines
Deal found 4/1![United Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:30 am
DSM
- STL
1 stop6h 00m
Southwest
Sat 4/255:40 am
STL
- DSM
1 stop5h 50m
Southwest
Deal found 3/31![Southwest logo]()
$288
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:20 am
OMA
- STL
Nonstop1h 15m
Southwest
Mon 4/273:50 pm
STL
- OMA
2 stops9h 10m
Southwest
Deal found 4/1![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:30 am
DSM
- STL
1 stop6h 00m
Southwest
Wed 5/63:55 pm
STL
- DSM
1 stop5h 20m
Southwest
Deal found 4/1![Southwest logo]()
$279
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:37 pm
LSE
- MCI
1 stop5h 22m
American Airlines
Fri 5/85:35 am
MCI
- LSE
1 stop3h 49m
American Airlines
Deal found 4/1![American Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:50 pm
OMA
- STL
Nonstop1h 15m
Southwest
Sat 5/910:35 am
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 4/1![Southwest logo]()
$269
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:40 pm
OMA
- STL
Nonstop1h 15m
Southwest
Wed 5/68:25 am
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 4/2![Southwest logo]()
$263
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:55 am
DSM
- STL
2 stops6h 05m
Southwest
Thu 5/79:55 am
STL
- DSM
2 stops13h 10m
Southwest
Deal found 4/1![Southwest logo]()
$304
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:34 am
OMA
- STL
1 stop3h 58m
Delta
Mon 5/115:36 pm
STL
- OMA
1 stop5h 20m
Delta
Deal found 3/31![Delta logo]()
$279
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/164:00 pm
DSM
- STL
1 stop5h 29m
Delta
Sat 5/235:36 pm
STL
- DSM
1 stop3h 27m
Delta
Deal found 3/31![Delta logo]()
$297
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:20 pm
OMA
- STL
1 stop4h 30m
Southwest
Mon 6/18:25 am
STL
- OMA
1 stop4h 30m
Southwest
Deal found 4/1![Southwest logo]()
$289
One-way flights from Iowa to MissouriSearch for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated April 3, 2026.
Search for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated April 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:19 pm
OMA
- STL
1 stop23h 04m
Frontier
Deal found 4/3![Frontier logo]()
$66
This Frontier deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- STL
1 stop5h 17m
Frontier
Deal found 3/31![Frontier logo]()
$70
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/28:19 pm
OMA
- STL
1 stop23h 04m
Frontier
Deal found 4/1![Frontier logo]()
$78
This Trip.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:49 pm
OMA
- MCI
1 stop17h 17m
Frontier
Deal found 4/2![Frontier logo]()
$85
This Frontier deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- STL
1 stop5h 07m
Frontier
Deal found 3/30![Frontier logo]()
$90
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/308:58 pm
OMA
- STL
1 stop22h 23m
Frontier
Deal found 4/3![Frontier logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/308:29 pm
OMA
- STL
1 stop22h 54m
Frontier
Deal found 3/31![Frontier logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/38:58 pm
OMA
- STL
1 stop22h 34m
Frontier
Deal found 4/3![Frontier logo]()
$111
This Frontier deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- STL
1 stop5h 07m
Frontier
Deal found 3/30![Frontier logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:49 pm
OMA
- STL
1 stop22h 43m
Frontier
Deal found 3/31![Frontier logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:43 pm
OMA
- STL
2 stops36h 12m
Frontier
Deal found 4/3![Frontier logo]()
$114
This Frontier deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/262:16 pm
DSM
- STL
1 stop5h 07m
Frontier
Deal found 3/29![Frontier logo]()
$115
Find flight deals from Iowa to Missouri
Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated April 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $256 (Kiwi.com) |
One-way from | $66 (Kiwi.com) |
Popular in | July |
Cheapest in | September |
Average price | $298 |
Good round-trip deal | $105 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Mon 5/4
5:21 pm-11:13 pm
1 stop5h 52m
Lambert-St Louis
Wed 5/6
5:35 pm-9:22 pm
1 stop3h 47m
$273
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Mon 5/4
5:40 pm-6:55 pm
Nonstop1h 15m
Lambert-St Louis
Wed 5/6
8:35 am-1:15 pm
1 stop4h 40m
$273
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Wed 6/3
6:25 pm-10:44 pm
1 stop4h 19m
Lambert-St Louis
Thu 6/4
6:00 am-10:27 am
1 stop4h 27m
$273
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Thu 4/23
7:35 pm-11:46 pm
1 stop4h 11m
Lambert-St Louis
Mon 4/27
9:10 am-4:22 pm
1 stop7h 12m
$279
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Thu 4/23
7:20 pm-11:50 pm
1 stop4h 30m
Lambert-St Louis
Mon 4/27
9:40 pm-11:00 pm
Nonstop1h 20m
$279
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 4/29
5:30 am-11:30 am
1 stop6h 00m
Lambert-St Louis
Wed 5/6
3:55 pm-9:15 pm
1 stop5h 20m
$279
OmahaColumbia
OMA - COU
OMACOU
Omaha Eppley Airfield
Wed 8/19
10:00 am-2:30 pm
1 stop4h 30m
Columbia Regional
Sat 8/22
6:30 pm-12:45 am
1 stop6h 15m
$288
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 5/5
6:55 am-1:50 pm
1 stop6h 55m
Lambert-St Louis
Thu 5/7
5:40 am-11:45 am
1 stop6h 05m
$288
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Sat 5/16
4:00 pm-9:29 pm
1 stop5h 29m
Lambert-St Louis
Sat 5/23
5:36 pm-9:03 pm
1 stop3h 27m
$297
La CrosseKansas City
LSE - MCI
LSEMCI
La Crosse
Thu 4/30
6:37 pm-11:59 pm
1 stop5h 22m
Kansas City
Fri 5/8
5:35 am-9:24 am
1 stop3h 49m
$298
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
OMA-STL
OMA-MCI
OMA-COU
DSM-STL
LSE-MCI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to Missouri
USIA-USMO
OMA-STL
OMA-MCI
OMA-COU
DSM-STL
What is the cheapest month to book a flight from Iowa to Missouri?
Currently, May is the cheapest month in which you can book a flight from Iowa to Missouri (average of $92). Flying from Iowa to Missouri in January is currently the most expensive (average of $275). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Iowa to Missouri?
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated April 3, 2026.
Peruse reviews from past customers who have flown with Southwest,United Airlines, andAmerican Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Iowa to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to Missouri by cabin class
Find flights from Iowa to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and Missouri flights
Browse other Iowa and Missouri flight options. Last updated on April 3, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to Iowa after your stay in Missouri
Iowa to Missouri flights
Consider these flights traveling from Iowa to Missouri.
Top 3 airlines flying from Iowa to Missouri
Discover the top 3 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$107 | Average$253 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$218 | Average$418 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$218 | Average$297 | FlexibilityNo cancel fee | On-time71% |