$108+ Cheap flights from Iowa to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MCI
Jul 28 — Aug 41
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Iowa to Missouri with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to Missouri
Cheapest
Best
Last-minute
One-way
Cheapest flights from Iowa to MissouriExplore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 28, 2026.
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 28, 2026.
This United Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:00 am
DSM
- STL
1 stop6h 11m
United Airlines
Sat 8/158:00 am
STL
- DSM
1 stop4h 18m
United Airlines
Deal found 6/27![United Airlines logo]()
$209
This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:35 am
DSM
- STL
1 stop3h 25m
Southwest
Sat 10/318:40 am
STL
- DSM
1 stop4h 55m
Southwest
Deal found 6/26![Southwest logo]()
$222
This Delta deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:59 pm
DSM
- STL
1 stop5h 17m
Delta
Tue 9/226:15 am
STL
- DSM
1 stop4h 02m
Delta
Deal found 6/25![Delta logo]()
$235
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:50 pm
DSM
- STL
1 stop6h 15m
Southwest
Wed 9/164:05 pm
STL
- DSM
1 stop4h 55m
Southwest
Deal found 6/25![Southwest logo]()
$252
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:40 am
DSM
- STL
1 stop3h 35m
Southwest
Tue 9/222:50 pm
STL
- DSM
2 stops6h 10m
Southwest
Deal found 6/25![Southwest logo]()
$254
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:07 pm
OMA
- STL
1 stop4h 20m
American Airlines
Sat 10/35:00 am
STL
- OMA
1 stop4h 47m
American Airlines
Deal found 6/27![American Airlines logo]()
$261
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:00 am
DSM
- STL
1 stop5h 55m
American Airlines
Sat 8/158:06 pm
STL
- DSM
1 stop4h 29m
American Airlines
Deal found 6/24![American Airlines logo]()
$263
This Southwest deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:30 am
DSM
- STL
2 stops7h 05m
Southwest
Sat 8/155:45 am
STL
- DSM
1 stop5h 45m
Southwest
Deal found 6/27![Southwest logo]()
$267
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:16 am
OMA
- COU
1 stop3h 51m
American Airlines
Tue 10/208:00 pm
COU
- OMA
1 stop3h 42m
American Airlines
Deal found 6/27![American Airlines logo]()
$268
This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/144:35 pm
OMA
- STL
Nonstop1h 10m
Southwest
Wed 10/148:50 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 6/26![Southwest logo]()
$269
This Southwest deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:10 pm
OMA
- STL
Nonstop1h 15m
Southwest
Wed 7/229:20 pm
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 6/28![Southwest logo]()
$275
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:51 pm
CID
- MCI
1 stop5h 28m
American Airlines
Mon 7/207:46 pm
MCI
- CID
1 stop4h 03m
American Airlines
Deal found 6/25![American Airlines logo]()
$279
Best flights from Iowa to MissouriDiscover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 28, 2026.
Discover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 28, 2026.
This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:35 am
DSM
- STL
2 stops7h 55m
Southwest
Sat 10/316:00 am
STL
- DSM
1 stop6h 10m
Southwest
Deal found 6/26![Southwest logo]()
$227
This Delta deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:59 pm
DSM
- STL
1 stop5h 17m
Delta
Tue 9/226:15 am
STL
- DSM
1 stop4h 02m
Delta
Deal found 6/25![Delta logo]()
$235
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:00 am
DSM
- STL
1 stop5h 55m
American Airlines
Sat 8/158:06 pm
STL
- DSM
1 stop4h 29m
American Airlines
Deal found 6/24![American Airlines logo]()
$263
This United Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:00 am
DSM
- STL
1 stop3h 57m
United Airlines
Wed 9/238:50 am
STL
- DSM
1 stop5h 30m
United Airlines
Deal found 6/26![United Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/264:57 pm
DSM
- MCI
2 stops24h 13m
Multiple Airlines
Sun 8/21:45 pm
MCI
- DSM
1 stop23h 49m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:15 pm
OMA
- MCI
2 stops20h 55m
Frontier
Tue 7/281:45 pm
MCI
- OMA
1 stop5h 30m
Frontier
Deal found 6/23![Frontier logo]()
$354
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:40 am
DSM
- STL
2 stops12h 45m
Southwest
Wed 9/164:05 pm
STL
- DSM
1 stop4h 55m
Southwest
Deal found 6/25![Southwest logo]()
$257
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:51 pm
CID
- MCI
1 stop5h 28m
American Airlines
Mon 7/207:46 pm
MCI
- CID
1 stop4h 03m
American Airlines
Deal found 6/26![American Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:39 pm
OMA
- STL
1 stop5h 47m
Delta
Sat 8/155:34 pm
STL
- OMA
1 stop5h 24m
Delta
Deal found 6/24![Delta logo]()
$285
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:20 am
DSM
- STL
1 stop5h 55m
Southwest
Wed 7/295:55 pm
STL
- DSM
1 stop4h 55m
Southwest
Deal found 6/24![Southwest logo]()
$263
This United Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:33 pm
CID
- MCI
1 stop4h 44m
United Airlines
Fri 7/316:41 pm
MCI
- CID
1 stop4h 01m
United Airlines
Deal found 6/24![United Airlines logo]()
$310
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/912:06 pm
OMA
- COU
1 stop6h 50m
American Airlines
Mon 7/135:19 pm
COU
- OMA
1 stop6h 03m
American Airlines
Deal found 6/24![American Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:25 am
DSM
- STL
1 stop4h 40m
Southwest
Wed 11/112:30 pm
STL
- DSM
1 stop6h 15m
Southwest
Deal found 6/24![Southwest logo]()
$271
This United Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:40 pm
OMA
- COU
1 stop4h 53m
United Airlines
Sun 8/1610:55 am
COU
- OMA
1 stop6h 30m
United Airlines
Deal found 6/27![United Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:20 am
OMA
- COU
1 stop4h 56m
American Airlines
Sun 8/166:41 pm
COU
- OMA
1 stop5h 29m
American Airlines
Deal found 6/24![American Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:10 pm
OMA
- STL
Nonstop1h 15m
Southwest
Wed 7/229:20 pm
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 6/28![Southwest logo]()
$275
This United Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/229:00 am
OMA
- STL
1 stop7h 34m
United Airlines
Wed 9/238:00 am
STL
- OMA
1 stop4h 20m
United Airlines
Deal found 6/27![United Airlines logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/175:55 pm
CID
- MCI
2 stops23h 15m
Multiple Airlines
Mon 7/2010:40 am
MCI
- CID
1 stop25h 06m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:10 am
DSM
- STL
2 stops8h 15m
Southwest
Mon 9/283:15 pm
STL
- DSM
2 stops6h 55m
Southwest
Deal found 6/25![Southwest logo]()
$281
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1012:06 pm
OMA
- SGF
1 stop7h 01m
American Airlines
Tue 7/147:53 pm
SGF
- OMA
1 stop4h 44m
American Airlines
Deal found 6/25![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/411:23 am
OMA
- STL
1 stop4h 23m
United Airlines
Sun 8/98:00 am
STL
- OMA
1 stop4h 16m
United Airlines
Deal found 6/28![United Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/254:45 pm
OMA
- STL
Nonstop1h 15m
Southwest
Sat 8/18:25 am
STL
- OMA
1 stop6h 30m
Southwest
Deal found 6/26![Southwest logo]()
$285
This American Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:05 pm
OMA
- SGF
1 stop6h 29m
American Airlines
Fri 7/317:53 pm
SGF
- OMA
1 stop4h 44m
American Airlines
Deal found 6/23![American Airlines logo]()
$324
This United Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:35 pm
OMA
- COU
1 stop4h 20m
United Airlines
Tue 9/19:00 am
COU
- OMA
1 stop7h 28m
United Airlines
Deal found 6/26![United Airlines logo]()
$338
This Kiwi.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/123:01 pm
CID
- MCI
1 stop21h 59m
Multiple Airlines
Wed 7/156:07 pm
MCI
- CID
2 stops37h 55m
Multiple Airlines
Deal found 6/25![Multiple Airlines logo]()
$451
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/122:15 pm
OMA
- STL
Nonstop1h 15m
Southwest
Mon 9/142:15 pm
STL
- OMA
1 stop6h 45m
Southwest
Deal found 6/25![Southwest logo]()
$292
This United Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:27 pm
OMA
- SGF
1 stop6h 15m
United Airlines
Wed 7/151:33 pm
SGF
- OMA
1 stop4h 46m
United Airlines
Deal found 6/26![United Airlines logo]()
$338
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/112:30 pm
OMA
- STL
2 stops7h 10m
Southwest
Sat 8/1510:15 am
STL
- OMA
1 stop7h 50m
Southwest
Deal found 6/24![Southwest logo]()
$300
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am
CID
- MCI
1 stop4h 25m
United Airlines
Sat 9/55:08 pm
MCI
- CID
1 stop4h 11m
United Airlines
Deal found 6/23![United Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/258:00 pm
OMA
- COU
2 stops37h 16m
Multiple Airlines
Sat 8/15:48 pm
COU
- OMA
1 stop15h 10m
Multiple Airlines
Deal found 6/27![Multiple Airlines logo]()
$516
Last-minute flights from Iowa to MissouriDiscover last-minute flight deals from Iowa to Missouri. Data last updated June 28, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to Missouri. Data last updated June 28, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:05 pm
OMA
- COU
1 stop5h 15m
American Airlines
Sun 7/126:20 am
COU
- OMA
1 stop4h 58m
American Airlines
Deal found 6/28![American Airlines logo]()
$308
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/912:06 pm
OMA
- COU
1 stop6h 50m
American Airlines
Mon 7/135:19 pm
COU
- OMA
1 stop6h 03m
American Airlines
Deal found 6/24![American Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:51 pm
CID
- MCI
1 stop5h 28m
American Airlines
Mon 7/207:46 pm
MCI
- CID
1 stop4h 03m
American Airlines
Deal found 6/25![American Airlines logo]()
$279
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:51 pm
CID
- MCI
1 stop5h 28m
American Airlines
Sun 7/197:46 pm
MCI
- CID
1 stop4h 03m
American Airlines
Deal found 6/25![American Airlines logo]()
$294
This United Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/173:24 pm
DSM
- STL
1 stop3h 59m
United Airlines
Sat 7/185:59 pm
STL
- DSM
1 stop5h 01m
United Airlines
Deal found 6/25![United Airlines logo]()
$304
This Southwest deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:10 pm
OMA
- STL
Nonstop1h 15m
Southwest
Wed 7/229:20 pm
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 6/28![Southwest logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:15 pm
OMA
- MCI
1 stop16h 45m
Frontier
Tue 7/281:45 pm
MCI
- OMA
1 stop5h 30m
Frontier
Deal found 6/23![Frontier logo]()
$303
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:20 am
DSM
- STL
1 stop5h 55m
Southwest
Wed 7/295:55 pm
STL
- DSM
1 stop4h 55m
Southwest
Deal found 6/24![Southwest logo]()
$263
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/254:45 pm
OMA
- STL
Nonstop1h 15m
Southwest
Sat 8/18:25 am
STL
- OMA
1 stop6h 30m
Southwest
Deal found 6/25![Southwest logo]()
$285
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/254:42 pm
OMA
- COU
1 stop4h 33m
American Airlines
Sat 8/16:30 am
COU
- OMA
1 stop4h 48m
American Airlines
Deal found 6/27![American Airlines logo]()
$303
This American Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/265:00 am
DSM
- STL
1 stop3h 37m
American Airlines
Tue 7/285:58 pm
STL
- DSM
1 stop6h 03m
American Airlines
Deal found 6/28![American Airlines logo]()
$277
This United Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:00 am
DSM
- STL
1 stop6h 11m
United Airlines
Sat 8/16:00 am
STL
- DSM
1 stop4h 17m
United Airlines
Deal found 6/24![United Airlines logo]()
$280
One-way flights from Iowa to MissouriSearch for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated June 28, 2026.
Search for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated June 28, 2026.
This United Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:37 am
DSM
- STL
1 stop4h 53m
United Airlines
Deal found 6/26![United Airlines logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:50 pm
OMA
- STL
1 stop22h 00m
Multiple Airlines
Deal found 6/27![Multiple Airlines logo]()
$116
This Frontier deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:18 pm
OMA
- STL
1 stop4h 55m
Frontier
Deal found 6/24![Frontier logo]()
$122
This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:25 am
DSM
- STL
2 stops9h 50m
Southwest
Deal found 6/26![Southwest logo]()
$123
This Priceline deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:18 pm
OMA
- STL
1 stop4h 55m
Frontier
Deal found 6/24![Frontier logo]()
$126
This American Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2211:59 am
OMA
- STL
1 stop6h 06m
American Airlines
Deal found 6/28![American Airlines logo]()
$131
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:00 am
DSM
- STL
1 stop4h 11m
United Airlines
Deal found 6/23![United Airlines logo]()
$132
This Frontier deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/232:18 pm
OMA
- STL
1 stop4h 55m
Frontier
Deal found 6/24![Frontier logo]()
$135
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:20 am
DSM
- STL
2 stops9h 30m
Southwest
Deal found 6/23![Southwest logo]()
$137
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:10 pm
OMA
- STL
Nonstop1h 15m
Southwest
Deal found 6/24![Southwest logo]()
$138
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:00 am
OMA
- STL
1 stop4h 28m
Delta
Deal found 6/28![Delta logo]()
$143
This Trip.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:00 pm
OMA
- STL
1 stop23h 23m
Frontier
Deal found 6/24![Frontier logo]()
$145
Find flight deals from Iowa to Missouri
Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated June 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $209 (United Airlines) |
One-way from | $108 (United Airlines) |
Popular in | July |
Cheapest in | May |
Average price | $371 |
Good round-trip deal | $462 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 28, 2026.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 10/28
5:35 am-1:30 pm
2 stops7h 55m
Lambert-St Louis
Sat 10/31
6:00 am-12:10 pm
1 stop6h 10m
$227
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Mon 9/14
5:59 pm-11:16 pm
1 stop5h 17m
Lambert-St Louis
Tue 9/22
6:15 am-10:17 am
1 stop4h 02m
$235
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Mon 9/14
5:40 am-6:25 pm
2 stops12h 45m
Lambert-St Louis
Wed 9/16
4:05 pm-9:00 pm
1 stop4h 55m
$257
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Sat 8/8
7:00 am-12:55 pm
1 stop5h 55m
Lambert-St Louis
Sat 8/15
8:06 pm-12:35 am
1 stop4h 29m
$263
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 7/22
5:20 am-11:15 am
1 stop5h 55m
Lambert-St Louis
Wed 7/29
5:55 pm-10:50 pm
1 stop4h 55m
$263
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Mon 11/2
5:25 am-10:05 am
1 stop4h 40m
Lambert-St Louis
Wed 11/11
2:30 pm-8:45 pm
1 stop6h 15m
$271
Quickest round-trip
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Tue 7/21
5:10 pm-6:25 pm
Nonstop1h 15m
Lambert-St Louis
Wed 7/22
9:20 pm-10:40 pm
Nonstop1h 20m
$275
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 9/22
8:00 am-11:57 am
1 stop3h 57m
Lambert-St Louis
Wed 9/23
8:50 am-2:20 pm
1 stop5h 30m
$279
Cedar RapidsKansas City
CID - MCI
CIDMCI
Cedar Rapids
Fri 7/17
6:51 pm-12:19 am
1 stop5h 28m
Kansas City
Mon 7/20
7:46 pm-11:49 pm
1 stop4h 03m
$279
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 9/23
6:10 am-2:25 pm
2 stops8h 15m
Lambert-St Louis
Mon 9/28
3:15 pm-10:10 pm
2 stops6h 55m
$281
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
DSM-STL
DSM-MCI
OMA-MCI
CID-MCI
OMA-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to Missouri
USIA-USMO
DSM-STL
DSM-MCI
OMA-MCI
CID-MCI
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated June 28, 2026.
Peruse reviews from past customers who have flown with Southwest and American Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Comfort
8.0
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
7.9
Comfort
8.0
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
7.9
Comfort
8.0
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Return Flight Options
Top destinations
Alternative routes for Iowa to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to Missouri by cabin class
Find flights from Iowa to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and Missouri flights
Browse other Iowa and Missouri flight options. Last updated on June 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to Iowa after your stay in Missouri
Iowa to Missouri flights
Consider these flights traveling from Iowa to Missouri.
Top 2 airlines flying from Iowa to Missouri
Discover the top 2 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$97 | Average$250 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$158 | Average$344 | FlexibilityNo cancel fee | On-time71% |