$110+ Cheap flights from Iowa to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/30. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Aug 21 — Aug 281
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Iowa to Missouri with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to Missouri
Cheapest
Best
Last-minute
One-way
Cheapest flights from Iowa to MissouriExplore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 22, 2026.
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 22, 2026.
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/193:20 pm
DSM
- STL
1 stop6h 40m
United Airlines
Wed 8/268:50 am
STL
- DSM
1 stop5h 26m
United Airlines
Deal found 7/21![United Airlines logo]()
$219
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:25 pm
DSM
- STL
1 stop5h 20m
Southwest
Mon 9/146:25 am
STL
- DSM
1 stop7h 20m
Southwest
Deal found 7/19![Southwest logo]()
$222
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/192:40 pm
DSM
- STL
1 stop3h 15m
Southwest
Wed 8/2610:15 am
STL
- DSM
2 stops11h 40m
Southwest
Deal found 7/21![Southwest logo]()
$224
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:10 am
DSM
- STL
2 stops12h 00m
Southwest
Thu 10/85:25 am
STL
- DSM
1 stop5h 45m
Southwest
Deal found 7/21![Southwest logo]()
$230
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/153:20 pm
DSM
- STL
1 stop6h 40m
United Airlines
Sat 8/228:00 am
STL
- DSM
1 stop6h 16m
United Airlines
Deal found 7/17![United Airlines logo]()
$235
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:20 am
OMA
- STL
Nonstop1h 15m
Southwest
Wed 8/268:30 am
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/22![Southwest logo]()
$237
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:40 pm
DSM
- STL
1 stop3h 15m
Southwest
Tue 8/183:05 pm
STL
- DSM
2 stops6h 50m
Southwest
Deal found 7/17![Southwest logo]()
$240
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:40 am
DSM
- STL
1 stop3h 35m
Southwest
Sat 9/198:30 am
STL
- DSM
2 stops10h 55m
Southwest
Deal found 7/19![Southwest logo]()
$246
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/238:15 am
OMA
- STL
Nonstop1h 20m
Southwest
Tue 12/18:25 am
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 7/19![Southwest logo]()
$255
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:20 pm
OMA
- STL
1 stop4h 25m
Southwest
Mon 10/126:05 am
STL
- OMA
1 stop4h 55m
Southwest
Deal found 7/22![Southwest logo]()
$257
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:55 am
OMA
- COU
1 stop5h 18m
American Airlines
Fri 8/286:35 pm
COU
- OMA
1 stop5h 35m
American Airlines
Deal found 7/21![American Airlines logo]()
$268
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:44 pm
OMA
- STL
1 stop4h 30m
American Airlines
Mon 9/145:18 pm
STL
- OMA
1 stop6h 55m
American Airlines
Deal found 7/22![American Airlines logo]()
$270
Best flights from Iowa to MissouriDiscover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 22, 2026.
Discover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 22, 2026.
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/193:20 pm
DSM
- STL
1 stop6h 40m
United Airlines
Wed 8/268:50 am
STL
- DSM
1 stop5h 26m
United Airlines
Deal found 7/21![United Airlines logo]()
$219
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:10 am
DSM
- STL
1 stop3h 50m
Southwest
Thu 10/85:25 am
STL
- DSM
1 stop5h 45m
Southwest
Deal found 7/21![Southwest logo]()
$219
This American Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:49 pm
DSM
- STL
1 stop4h 25m
American Airlines
Tue 8/181:25 pm
STL
- DSM
1 stop5h 54m
American Airlines
Deal found 7/17![American Airlines logo]()
$235
This Delta deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:05 am
OMA
- STL
1 stop6h 42m
Delta
Sat 8/296:20 am
STL
- OMA
1 stop5h 40m
Delta
Deal found 7/22![Delta logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/158:00 pm
OMA
- MCI
1 stop17h 00m
Frontier
Sat 8/221:38 pm
MCI
- OMA
1 stop23h 55m
Frontier
Deal found 7/17![Frontier logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:38 pm
CID
- MCI
1 stop22h 15m
Multiple Airlines
Sun 8/231:38 pm
MCI
- CID
2 stops30h 42m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$437
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:25 pm
DSM
- STL
1 stop5h 20m
Southwest
Mon 9/146:25 am
STL
- DSM
1 stop7h 20m
Southwest
Deal found 7/19![Southwest logo]()
$222
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/192:40 pm
DSM
- STL
1 stop3h 15m
Southwest
Wed 8/2610:15 am
STL
- DSM
2 stops11h 40m
Southwest
Deal found 7/21![Southwest logo]()
$224
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:35 pm
OMA
- COU
1 stop4h 20m
United Airlines
Mon 8/243:12 pm
COU
- OMA
1 stop6h 46m
United Airlines
Deal found 7/20![United Airlines logo]()
$268
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:00 am
CID
- MCI
1 stop3h 40m
American Airlines
Tue 8/255:00 am
MCI
- CID
1 stop6h 26m
American Airlines
Deal found 7/21![American Airlines logo]()
$278
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:40 am
DSM
- STL
1 stop3h 35m
Southwest
Sat 9/198:55 am
STL
- DSM
1 stop5h 15m
Southwest
Deal found 7/19![Southwest logo]()
$235
This Delta deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1511:00 am
CID
- MCI
1 stop3h 42m
Delta
Fri 10/235:20 pm
MCI
- CID
1 stop5h 45m
Delta
Deal found 7/22![Delta logo]()
$289
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/285:00 am
CID
- MCI
1 stop3h 40m
American Airlines
Mon 8/317:39 pm
MCI
- CID
1 stop4h 39m
American Airlines
Deal found 7/22![American Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/232:40 pm
DSM
- STL
1 stop3h 15m
Southwest
Mon 9/283:15 pm
STL
- DSM
2 stops6h 55m
Southwest
Deal found 7/17![Southwest logo]()
$240
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:20 am
OMA
- SGF
1 stop4h 37m
American Airlines
Tue 8/258:04 pm
SGF
- OMA
1 stop4h 06m
American Airlines
Deal found 7/21![American Airlines logo]()
$289
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:40 pm
DSM
- STL
1 stop3h 15m
Southwest
Tue 8/183:05 pm
STL
- DSM
2 stops6h 50m
Southwest
Deal found 7/17![Southwest logo]()
$240
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:48 pm
CID
- MCI
1 stop5h 47m
American Airlines
Sun 8/97:39 pm
MCI
- CID
1 stop4h 39m
American Airlines
Deal found 7/19![American Airlines logo]()
$294
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:15 am
OMA
- SGF
1 stop8h 01m
United Airlines
Wed 9/24:58 pm
SGF
- OMA
1 stop5h 12m
United Airlines
Deal found 7/20![United Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:20 am
OMA
- STL
Nonstop1h 15m
Southwest
Sat 8/227:00 am
STL
- OMA
1 stop6h 40m
Southwest
Deal found 7/21![Southwest logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/48:15 pm
OMA
- MCI
1 stop16h 45m
Frontier
Fri 8/74:32 pm
MCI
- OMA
2 stops26h 43m
Frontier
Deal found 7/21![Frontier logo]()
$424
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:25 am
CID
- MCI
1 stop4h 04m
United Airlines
Mon 8/105:37 pm
MCI
- CID
1 stop5h 05m
United Airlines
Deal found 7/20![United Airlines logo]()
$364
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:20 pm
OMA
- STL
1 stop4h 25m
Southwest
Mon 10/126:05 am
STL
- OMA
1 stop4h 55m
Southwest
Deal found 7/22![Southwest logo]()
$257
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:40 am
OMA
- STL
2 stops9h 10m
Southwest
Sat 8/292:15 pm
STL
- OMA
1 stop5h 25m
Southwest
Deal found 7/22![Southwest logo]()
$262
This United Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:00 pm
OMA
- SGF
1 stop4h 42m
United Airlines
Sun 9/206:37 pm
SGF
- OMA
1 stop4h 27m
United Airlines
Deal found 7/18![United Airlines logo]()
$394
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/18:00 pm
OMA
- MCI
1 stop17h 00m
Frontier
Tue 8/41:45 pm
MCI
- OMA
1 stop5h 30m
Frontier
Deal found 7/19![Frontier logo]()
$499
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:30 am
OMA
- STL
2 stops6h 15m
Southwest
Wed 8/266:30 am
STL
- OMA
1 stop5h 10m
Southwest
Deal found 7/22![Southwest logo]()
$262
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:00 am
ALO
- STL
1 stop31h 54m
American Airlines
Mon 8/246:00 am
STL
- ALO
1 stop8h 52m
American Airlines
Deal found 7/20![American Airlines logo]()
$387
This Southwest deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/264:40 pm
OMA
- STL
Nonstop1h 15m
Southwest
Wed 9/98:50 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/18![Southwest logo]()
$273
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:30 am
CID
- MCI
1 stop7h 08m
United Airlines
Sat 8/89:10 am
MCI
- CID
1 stop5h 05m
United Airlines
Deal found 7/20![United Airlines logo]()
$493
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/183:05 pm
OMA
- STL
1 stop6h 35m
Southwest
Mon 8/248:30 am
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/20![Southwest logo]()
$283
Last-minute flights from Iowa to MissouriDiscover last-minute flight deals from Iowa to Missouri. Data last updated July 22, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to Missouri. Data last updated July 22, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:00 am
OMA
- COU
1 stop4h 13m
United Airlines
Sat 8/153:12 pm
COU
- OMA
1 stop6h 46m
United Airlines
Deal found 7/17![United Airlines logo]()
$268
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/114:40 pm
OMA
- STL
Nonstop1h 15m
Southwest
Thu 8/138:30 am
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/17![Southwest logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:15 pm
OMA
- STL
2 stops12h 42m
Frontier
Thu 8/138:08 pm
STL
- OMA
1 stop23h 07m
Frontier
Deal found 7/17![Frontier logo]()
$281
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:40 pm
DSM
- STL
1 stop3h 15m
Southwest
Tue 8/183:05 pm
STL
- DSM
2 stops6h 50m
Southwest
Deal found 7/17![Southwest logo]()
$240
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/153:20 pm
DSM
- STL
1 stop6h 40m
United Airlines
Sat 8/228:00 am
STL
- DSM
1 stop6h 16m
United Airlines
Deal found 7/17![United Airlines logo]()
$235
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:30 am
DSM
- STL
2 stops10h 00m
Southwest
Sat 8/227:00 am
STL
- DSM
1 stop7h 10m
Southwest
Deal found 7/17![Southwest logo]()
$275
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1511:25 am
CID
- MCI
1 stop6h 05m
United Airlines
Mon 8/175:08 pm
MCI
- CID
1 stop5h 34m
United Airlines
Deal found 7/20![United Airlines logo]()
$279
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:00 am
CID
- MCI
1 stop3h 40m
American Airlines
Tue 8/255:00 am
MCI
- CID
1 stop6h 26m
American Airlines
Deal found 7/21![American Airlines logo]()
$278
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/193:20 pm
DSM
- STL
1 stop6h 40m
United Airlines
Wed 8/268:50 am
STL
- DSM
1 stop5h 26m
United Airlines
Deal found 7/21![United Airlines logo]()
$219
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/192:40 pm
DSM
- STL
1 stop3h 15m
Southwest
Wed 8/2610:15 am
STL
- DSM
2 stops11h 40m
Southwest
Deal found 7/21![Southwest logo]()
$224
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:20 am
OMA
- STL
Nonstop1h 15m
Southwest
Wed 8/268:30 am
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/22![Southwest logo]()
$237
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:10 am
DSM
- STL
1 stop3h 25m
Southwest
Fri 8/212:00 pm
STL
- DSM
1 stop7h 15m
Southwest
Deal found 7/20![Southwest logo]()
$282
One-way flights from Iowa to MissouriSearch for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated July 22, 2026.
Search for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated July 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/301:55 pm
DSM
- STL
2 stops27h 27m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$110
This American Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/317:49 pm
DSM
- STL
1 stop4h 25m
American Airlines
Deal found 7/18![American Airlines logo]()
$118
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:20 am
OMA
- STL
Nonstop1h 15m
Southwest
Deal found 7/22![Southwest logo]()
$119
This Frontier deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:18 pm
OMA
- STL
1 stop4h 55m
Frontier
Deal found 7/22![Frontier logo]()
$120
This Southwest deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:40 am
DSM
- STL
2 stops12h 45m
Southwest
Deal found 7/18![Southwest logo]()
$123
This Delta deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:10 am
OMA
- STL
1 stop4h 13m
Delta
Deal found 7/22![Delta logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:41 pm
OMA
- STL
1 stop22h 34m
Frontier
Deal found 7/21![Frontier logo]()
$125
This Frontier deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:18 pm
OMA
- STL
1 stop4h 55m
Frontier
Deal found 7/19![Frontier logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/113:01 pm
CID
- MCI
1 stop21h 59m
Frontier
Deal found 7/22![Frontier logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/218:41 pm
OMA
- STL
2 stops36h 59m
Frontier
Deal found 7/22![Frontier logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/188:41 pm
OMA
- STL
1 stop22h 34m
Frontier
Deal found 7/19![Frontier logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:41 pm
OMA
- STL
1 stop22h 34m
Frontier
Deal found 7/21![Frontier logo]()
$137
Find flight deals from Iowa to Missouri
Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated July 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $219 (United Airlines) |
One-way from | $110 (Kiwi.com) |
Popular in | February |
Cheapest in | May |
Average price | $570 |
Good round-trip deal | $462 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 22, 2026.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 8/19
3:20 pm-10:00 pm
1 stop6h 40m
Lambert-St Louis
Wed 8/26
8:50 am-2:16 pm
1 stop5h 26m
$219
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Thu 10/1
5:10 am-9:00 am
1 stop3h 50m
Lambert-St Louis
Thu 10/8
5:25 am-11:10 am
1 stop5h 45m
$219
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Fri 9/11
2:25 pm-7:45 pm
1 stop5h 20m
Lambert-St Louis
Mon 9/14
6:25 am-1:45 pm
1 stop7h 20m
$222
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 8/19
2:40 pm-5:55 pm
1 stop3h 15m
Lambert-St Louis
Wed 8/26
10:15 am-9:55 pm
2 stops11h 40m
$224
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 8/12
7:49 pm-12:14 am
1 stop4h 25m
Lambert-St Louis
Tue 8/18
1:25 pm-7:19 pm
1 stop5h 54m
$235
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Thu 9/17
5:40 am-9:15 am
1 stop3h 35m
Lambert-St Louis
Sat 9/19
8:55 am-2:10 pm
1 stop5h 15m
$235
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 9/23
2:40 pm-5:55 pm
1 stop3h 15m
Lambert-St Louis
Mon 9/28
3:15 pm-10:10 pm
2 stops6h 55m
$240
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 8/12
2:40 pm-5:55 pm
1 stop3h 15m
Lambert-St Louis
Tue 8/18
3:05 pm-9:55 pm
2 stops6h 50m
$240
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Sat 8/22
8:05 am-2:47 pm
1 stop6h 42m
Lambert-St Louis
Sat 8/29
6:20 am-12:00 pm
1 stop5h 40m
$247
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Wed 8/19
8:20 am-9:35 am
Nonstop1h 15m
Lambert-St Louis
Sat 8/22
7:00 am-1:40 pm
1 stop6h 40m
$247
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
DSM-STL
OMA-STL
OMA-COU
CID-MCI
OMA-MCI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to Missouri
USIA-USMO
DSM-STL
OMA-STL
OMA-COU
CID-MCI
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated July 22, 2026.
Peruse reviews from past customers who have flown with Southwest and American Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Return Flight Options
Top destinations
Alternative routes for Iowa to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to Missouri by cabin class
Find flights from Iowa to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and Missouri flights
Browse other Iowa and Missouri flight options. Last updated on July 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to Iowa after your stay in Missouri
Iowa to Missouri flights
Consider these flights traveling from Iowa to Missouri.
Top 2 airlines flying from Iowa to Missouri
Discover the top 2 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$107 | Average$250 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$158 | Average$356 | FlexibilityNo cancel fee | On-time71% |