$102+ Cheap flights from Iowa to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MCI
Jul 23 — Jul 301
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to Missouri with Cheapflights
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Cheapest flights from Iowa to MissouriExplore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 23, 2026.
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 23, 2026.
This Booking.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/288:15 pm
OMA
- STL
1 stop23h 08m
Frontier
Tue 8/48:08 pm
STL
- OMA
1 stop23h 07m
Frontier
Deal found 6/22![Frontier logo]()
$232
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/219:06 pm
OMA
- STL
1 stop20h 44m
Multiple Airlines
Thu 8/276:45 pm
STL
- OMA
1 stop25h 31m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$253
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:33 pm
DSM
- STL
1 stop5h 43m
American Airlines
Wed 7/295:58 pm
STL
- DSM
1 stop6h 03m
American Airlines
Deal found 6/22![American Airlines logo]()
$263
This Booking.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/238:15 pm
OMA
- STL
1 stop23h 08m
Frontier
Thu 7/308:08 pm
STL
- OMA
1 stop23h 07m
Frontier
Deal found 6/22![Frontier logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:01 pm
DSM
- STL
1 stop20h 04m
Multiple Airlines
Sat 7/254:57 pm
STL
- DSM
2 stops29h 50m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$267
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/224:58 pm
OMA
- COU
1 stop5h 22m
American Airlines
Wed 7/296:32 pm
COU
- OMA
1 stop6h 05m
American Airlines
Deal found 6/22![American Airlines logo]()
$268
This Mytrip deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/208:00 pm
OMA
- STL
1 stop23h 23m
Frontier
Mon 7/278:08 pm
STL
- OMA
1 stop23h 07m
Frontier
Deal found 6/22![Frontier logo]()
$269
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:55 am
DSM
- STL
1 stop5h 59m
American Airlines
Mon 8/318:07 pm
STL
- DSM
1 stop4h 13m
American Airlines
Deal found 6/19![American Airlines logo]()
$271
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:20 am
DSM
- STL
1 stop4h 15m
Southwest
Wed 7/2910:15 am
STL
- DSM
2 stops12h 35m
Southwest
Deal found 6/22![Southwest logo]()
$274
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:10 pm
OMA
- STL
Nonstop1h 15m
Southwest
Tue 8/48:50 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 6/22![Southwest logo]()
$275
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/262:40 pm
DSM
- STL
2 stops7h 30m
Southwest
Mon 8/318:30 am
STL
- DSM
1 stop5h 15m
Southwest
Deal found 6/19![Southwest logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1310:01 pm
DSM
- STL
1 stop20h 04m
Multiple Airlines
Sat 7/184:57 pm
STL
- DSM
2 stops29h 50m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$278
Best flights from Iowa to MissouriDiscover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 23, 2026.
Discover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 23, 2026.
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:33 pm
DSM
- STL
1 stop5h 43m
American Airlines
Wed 7/295:58 pm
STL
- DSM
1 stop6h 03m
American Airlines
Deal found 6/22![American Airlines logo]()
$263
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:20 am
DSM
- STL
1 stop4h 15m
Southwest
Wed 7/2910:15 am
STL
- DSM
2 stops12h 35m
Southwest
Deal found 6/22![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/105:56 pm
DSM
- STL
1 stop5h 30m
Delta
Tue 8/1811:13 am
STL
- DSM
1 stop5h 37m
Delta
Deal found 6/19![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/56:40 pm
OMA
- COU
1 stop4h 53m
United Airlines
Sat 7/113:25 pm
COU
- OMA
1 stop6h 14m
United Airlines
Deal found 6/19![United Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:41 pm
DSM
- MCI
2 stops25h 29m
Multiple Airlines
Tue 8/111:45 pm
MCI
- DSM
1 stop23h 49m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:15 pm
OMA
- MCI
1 stop16h 45m
Frontier
Tue 7/281:45 pm
MCI
- OMA
1 stop5h 30m
Frontier
Deal found 6/23![Frontier logo]()
$298
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:55 am
DSM
- STL
1 stop5h 59m
American Airlines
Mon 8/318:07 pm
STL
- DSM
1 stop4h 13m
American Airlines
Deal found 6/19![American Airlines logo]()
$271
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:20 am
OMA
- STL
Nonstop1h 15m
Southwest
Wed 9/98:30 am
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 6/22![Southwest logo]()
$275
This Southwest deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/84:40 pm
OMA
- STL
Nonstop1h 15m
Southwest
Wed 9/98:50 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 6/21![Southwest logo]()
$275
This United Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/56:00 am
OMA
- SGF
1 stop4h 46m
United Airlines
Sat 7/116:34 pm
SGF
- OMA
1 stop4h 40m
United Airlines
Deal found 6/18![United Airlines logo]()
$304
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/55:20 am
OMA
- COU
1 stop5h 54m
American Airlines
Sat 7/115:19 pm
COU
- OMA
1 stop6h 03m
American Airlines
Deal found 6/18![American Airlines logo]()
$283
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:33 pm
CID
- MCI
1 stop4h 44m
United Airlines
Sun 7/56:41 pm
MCI
- CID
1 stop4h 01m
United Airlines
Deal found 6/20![United Airlines logo]()
$314
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/103:50 pm
DSM
- STL
1 stop6h 15m
Southwest
Tue 8/183:05 pm
STL
- DSM
2 stops6h 50m
Southwest
Deal found 6/19![Southwest logo]()
$286
This American Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:05 pm
OMA
- COU
1 stop5h 15m
American Airlines
Sun 7/126:32 pm
COU
- OMA
1 stop6h 05m
American Airlines
Deal found 6/23![American Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/188:00 pm
OMA
- MCI
1 stop17h 00m
Frontier
Fri 7/241:45 pm
MCI
- OMA
1 stop5h 30m
Frontier
Deal found 6/19![Frontier logo]()
$380
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:45 am
DSM
- STL
1 stop6h 55m
United Airlines
Wed 9/25:30 pm
STL
- DSM
1 stop3h 53m
United Airlines
Deal found 6/22![United Airlines logo]()
$333
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:30 am
OMA
- COU
1 stop4h 54m
American Airlines
Mon 9/286:32 pm
COU
- OMA
1 stop5h 41m
American Airlines
Deal found 6/20![American Airlines logo]()
$303
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:30 pm
OMA
- STL
2 stops7h 40m
Southwest
Thu 8/66:00 am
STL
- OMA
1 stop6h 30m
Southwest
Deal found 6/20![Southwest logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/188:00 pm
OMA
- MCI
1 stop17h 00m
Frontier
Sat 7/251:45 pm
MCI
- OMA
1 stop5h 30m
Frontier
Deal found 6/20![Frontier logo]()
$384
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:00 am
DSM
- STL
1 stop5h 55m
American Airlines
Sun 8/98:07 pm
STL
- DSM
1 stop4h 13m
American Airlines
Deal found 6/18![American Airlines logo]()
$312
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/34:40 pm
DSM
- STL
1 stop6h 15m
Southwest
Mon 8/106:15 pm
STL
- DSM
1 stop3h 55m
Southwest
Deal found 6/19![Southwest logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/98:00 pm
OMA
- SGF
2 stops24h 09m
Multiple Airlines
Fri 8/147:55 pm
SGF
- OMA
1 stop21h 07m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$464
This United Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am
CID
- MCI
1 stop4h 25m
United Airlines
Sat 9/55:08 pm
MCI
- CID
1 stop4h 11m
United Airlines
Deal found 6/18![United Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/154:30 pm
DSM
- STL
2 stops8h 05m
Southwest
Sun 10/185:40 am
STL
- DSM
1 stop5h 45m
Southwest
Deal found 6/21![Southwest logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/188:00 pm
OMA
- MCI
1 stop17h 00m
Multiple Airlines
Sat 7/256:07 pm
MCI
- OMA
2 stops41h 14m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$466
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:33 pm
CID
- MCI
1 stop4h 44m
United Airlines
Tue 7/286:41 pm
MCI
- CID
1 stop4h 01m
United Airlines
Deal found 6/20![United Airlines logo]()
$354
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:30 am
DSM
- STL
2 stops7h 05m
Southwest
Sun 8/97:30 pm
STL
- DSM
1 stop3h 20m
Southwest
Deal found 6/18![Southwest logo]()
$317
This United Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/111:55 pm
OMA
- STL
1 stop6h 51m
United Airlines
Wed 8/128:00 am
STL
- OMA
1 stop6h 04m
United Airlines
Deal found 6/21![United Airlines logo]()
$355
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:30 am
OMA
- SGF
1 stop6h 53m
United Airlines
Tue 11/33:03 pm
SGF
- OMA
1 stop6h 44m
United Airlines
Deal found 6/20![United Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:10 pm
OMA
- STL
Nonstop1h 15m
Southwest
Thu 7/303:35 pm
STL
- OMA
1 stop4h 15m
Southwest
Deal found 6/20![Southwest logo]()
$333
Last-minute flights from Iowa to MissouriDiscover last-minute flight deals from Iowa to Missouri. Data last updated June 23, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to Missouri. Data last updated June 23, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/56:40 pm
OMA
- COU
1 stop4h 53m
United Airlines
Sat 7/113:25 pm
COU
- OMA
1 stop6h 14m
United Airlines
Deal found 6/19![United Airlines logo]()
$283
This American Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:05 pm
OMA
- COU
1 stop5h 15m
American Airlines
Sun 7/126:32 pm
COU
- OMA
1 stop6h 05m
American Airlines
Deal found 6/23![American Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1310:01 pm
DSM
- STL
1 stop20h 04m
Multiple Airlines
Sat 7/184:57 pm
STL
- DSM
2 stops29h 50m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$278
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:00 am
OMA
- STL
1 stop6h 53m
American Airlines
Wed 7/159:44 am
STL
- OMA
1 stop6h 34m
American Airlines
Deal found 6/20![American Airlines logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:01 pm
DSM
- STL
1 stop20h 04m
Multiple Airlines
Sat 7/254:57 pm
STL
- DSM
2 stops29h 50m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$267
This Mytrip deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/208:00 pm
OMA
- STL
1 stop23h 23m
Frontier
Mon 7/278:08 pm
STL
- OMA
1 stop23h 07m
Frontier
Deal found 6/22![Frontier logo]()
$269
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:33 pm
DSM
- STL
1 stop5h 43m
American Airlines
Wed 7/295:58 pm
STL
- DSM
1 stop6h 03m
American Airlines
Deal found 6/22![American Airlines logo]()
$263
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/224:58 pm
OMA
- COU
1 stop5h 22m
American Airlines
Wed 7/296:32 pm
COU
- OMA
1 stop6h 05m
American Airlines
Deal found 6/22![American Airlines logo]()
$268
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:20 am
DSM
- STL
1 stop4h 15m
Southwest
Wed 7/2910:15 am
STL
- DSM
2 stops12h 35m
Southwest
Deal found 6/22![Southwest logo]()
$274
This Booking.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/238:15 pm
OMA
- STL
1 stop23h 08m
Frontier
Thu 7/308:08 pm
STL
- OMA
1 stop23h 07m
Frontier
Deal found 6/22![Frontier logo]()
$264
This Booking.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/288:15 pm
OMA
- STL
1 stop23h 08m
Frontier
Tue 8/48:08 pm
STL
- OMA
1 stop23h 07m
Frontier
Deal found 6/22![Frontier logo]()
$232
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:10 pm
OMA
- STL
Nonstop1h 15m
Southwest
Tue 8/48:50 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 6/22![Southwest logo]()
$275
One-way flights from Iowa to MissouriSearch for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated June 23, 2026.
Search for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated June 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/148:15 pm
OMA
- STL
1 stop23h 08m
Frontier
Deal found 6/19![Frontier logo]()
$102
This Orbitz deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/152:19 pm
DSM
- STL
1 stop5h 04m
Frontier
Deal found 6/20![Frontier logo]()
$115
This Frontier deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:18 pm
OMA
- STL
1 stop4h 55m
Frontier
Deal found 6/20![Frontier logo]()
$122
This Frontier deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:18 pm
OMA
- STL
1 stop4h 55m
Frontier
Deal found 6/21![Frontier logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/291:49 pm
DSM
- MCI
1 stop25h 58m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$132
This United Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:00 am
DSM
- STL
1 stop4h 11m
United Airlines
Deal found 6/21![United Airlines logo]()
$132
This Frontier deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/232:18 pm
OMA
- STL
1 stop4h 55m
Frontier
Deal found 6/22![Frontier logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/163:37 pm
DSM
- MCI
2 stops25h 33m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$136
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:20 am
DSM
- STL
2 stops9h 30m
Southwest
Deal found 6/18![Southwest logo]()
$137
This Booking.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/278:00 pm
OMA
- STL
1 stop23h 23m
Frontier
Deal found 6/22![Frontier logo]()
$137
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/184:45 pm
OMA
- STL
Nonstop1h 15m
Southwest
Deal found 6/20![Southwest logo]()
$138
This United Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:00 am
DSM
- STL
1 stop4h 11m
United Airlines
Deal found 6/18![United Airlines logo]()
$140
Find flight deals from Iowa to Missouri
Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated June 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $232 (Booking.com) |
One-way from | $102 (Kiwi.com) |
Popular in | July |
Cheapest in | May |
Average price | $371 |
Good round-trip deal | $462 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 23, 2026.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 7/22
6:33 pm-12:16 am
1 stop5h 43m
Lambert-St Louis
Wed 7/29
5:58 pm-12:01 am
1 stop6h 03m
$263
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 8/26
6:55 am-12:54 pm
1 stop5h 59m
Lambert-St Louis
Mon 8/31
8:07 pm-12:20 am
1 stop4h 13m
$271
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 7/22
5:20 am-9:35 am
1 stop4h 15m
Lambert-St Louis
Wed 7/29
10:15 am-10:50 pm
2 stops12h 35m
$274
Quickest round-trip
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Wed 9/2
8:20 am-9:35 am
Nonstop1h 15m
Lambert-St Louis
Wed 9/9
8:30 am-9:45 am
Nonstop1h 15m
$275
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Tue 9/8
4:40 pm-5:55 pm
Nonstop1h 15m
Lambert-St Louis
Wed 9/9
8:50 pm-10:05 pm
Nonstop1h 15m
$275
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Mon 8/10
5:56 pm-11:26 pm
1 stop5h 30m
Lambert-St Louis
Tue 8/18
11:13 am-4:50 pm
1 stop5h 37m
$279
OmahaColumbia
OMA - COU
OMACOU
Omaha Eppley Airfield
Sun 7/5
6:40 pm-11:33 pm
1 stop4h 53m
Columbia Regional
Sat 7/11
3:25 pm-9:39 pm
1 stop6h 14m
$283
Des MoinesKansas City
DSM - MCI
DSMMCI
Des Moines
Thu 8/6
3:41 pm-5:10 pm
2 stops25h 29m
Kansas City
Tue 8/11
1:45 pm-1:34 pm
1 stop23h 49m
$283
OmahaColumbia
OMA - COU
OMACOU
Omaha Eppley Airfield
Sun 7/5
5:20 am-11:14 am
1 stop5h 54m
Columbia Regional
Sat 7/11
5:19 pm-11:22 pm
1 stop6h 03m
$283
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Mon 8/10
3:50 pm-10:05 pm
1 stop6h 15m
Lambert-St Louis
Tue 8/18
3:05 pm-9:55 pm
2 stops6h 50m
$286
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
OMA-STL
DSM-STL
DSM-MCI
OMA-COU
OMA-MCI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to Missouri
USIA-USMO
OMA-STL
DSM-STL
DSM-MCI
OMA-COU
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated June 23, 2026.
Peruse reviews from past customers who have flown with Southwest and American Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Boarding
8.1
Entertainment
7.5
Food
7.0
Comfort
8.0
Overall
7.9
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Crew
8.6
Boarding
8.1
Entertainment
7.5
Food
7.0
Comfort
8.0
Overall
7.9
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Crew
8.6
Boarding
8.1
Entertainment
7.5
Food
7.0
Comfort
8.0
Overall
7.9
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Related info for your journey
Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Iowa to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to Missouri by cabin class
Find flights from Iowa to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and Missouri flights
Browse other Iowa and Missouri flight options. Last updated on June 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to Iowa after your stay in Missouri
Iowa to Missouri flights
Consider these flights traveling from Iowa to Missouri.
Top 2 airlines flying from Iowa to Missouri
Discover the top 2 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$97 | Average$250 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$158 | Average$344 | FlexibilityNo cancel fee | On-time71% |