$89+ Cheap flights from Iowa to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MCI
Aug 14 — Aug 211
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to Missouri with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Iowa to MissouriExplore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 15, 2026.
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 15, 2026.
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/203:50 pm
DSM
- STL
1 stop6h 15m
Southwest
Mon 8/246:25 am
STL
- DSM
1 stop7h 20m
Southwest
Deal found 7/10![Southwest logo]()
$177
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:40 pm
DSM
- STL
1 stop3h 15m
Southwest
Wed 8/198:35 am
STL
- DSM
1 stop5h 20m
Southwest
Deal found 7/14![Southwest logo]()
$209
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/244:50 pm
OMA
- STL
Nonstop1h 15m
Southwest
Mon 8/318:30 am
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/10![Southwest logo]()
$237
This Southwest deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:40 pm
DSM
- STL
2 stops7h 30m
Southwest
Sat 8/85:45 am
STL
- DSM
1 stop5h 45m
Southwest
Deal found 7/11![Southwest logo]()
$244
This Frontier deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/68:15 pm
OMA
- STL
1 stop23h 08m
Frontier
Mon 8/108:08 pm
STL
- OMA
1 stop23h 07m
Frontier
Deal found 7/14![Frontier logo]()
$244
This United Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:00 am
DSM
- STL
1 stop4h 11m
United Airlines
Thu 8/66:00 am
STL
- DSM
1 stop4h 17m
United Airlines
Deal found 7/10![United Airlines logo]()
$247
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:50 am
OMA
- STL
1 stop6h 15m
Southwest
Mon 9/76:00 am
STL
- OMA
1 stop6h 30m
Southwest
Deal found 7/13![Southwest logo]()
$257
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:20 am
DSM
- STL
2 stops8h 10m
Southwest
Mon 9/76:05 am
STL
- DSM
1 stop5h 20m
Southwest
Deal found 7/13![Southwest logo]()
$259
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/97:56 pm
DSM
- STL
1 stop4h 02m
American Airlines
Wed 8/126:00 am
STL
- DSM
1 stop3h 56m
American Airlines
Deal found 7/10![American Airlines logo]()
$261
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/123:05 pm
OMA
- STL
2 stops7h 05m
Southwest
Wed 8/1912:20 pm
STL
- OMA
1 stop4h 25m
Southwest
Deal found 7/13![Southwest logo]()
$262
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/81:54 pm
OMA
- COU
1 stop4h 03m
American Airlines
Sun 8/96:41 pm
COU
- OMA
1 stop5h 29m
American Airlines
Deal found 7/12![American Airlines logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:19 pm
DSM
- STL
1 stop29h 04m
Frontier
Sun 8/96:34 pm
STL
- DSM
2 stops19h 00m
Frontier
Deal found 7/12![Frontier logo]()
$276
Best flights from Iowa to MissouriDiscover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 15, 2026.
Discover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 15, 2026.
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:10 am
DSM
- STL
1 stop3h 25m
Southwest
Tue 9/12:50 pm
STL
- DSM
2 stops6h 10m
Southwest
Deal found 7/10![Southwest logo]()
$182
This United Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:00 am
DSM
- STL
1 stop6h 11m
United Airlines
Sat 8/158:00 am
STL
- DSM
1 stop4h 18m
United Airlines
Deal found 7/11![United Airlines logo]()
$219
This Delta deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:39 pm
OMA
- STL
1 stop5h 47m
Delta
Mon 8/315:34 pm
STL
- OMA
1 stop5h 24m
Delta
Deal found 7/11![Delta logo]()
$247
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:55 am
OMA
- COU
1 stop5h 18m
American Airlines
Sun 8/306:41 pm
COU
- OMA
1 stop5h 29m
American Airlines
Deal found 7/12![American Airlines logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/128:00 pm
OMA
- MCI
1 stop17h 00m
Frontier
Wed 8/1911:26 am
MCI
- OMA
2 stops26h 07m
Frontier
Deal found 7/15![Frontier logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:24 pm
CID
- MCI
2 stops40h 17m
Multiple Airlines
Sun 8/234:47 pm
MCI
- CID
1 stop27h 33m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:40 am
DSM
- STL
2 stops9h 40m
Southwest
Mon 8/243:45 pm
STL
- DSM
2 stops6h 25m
Southwest
Deal found 7/10![Southwest logo]()
$187
This Southwest deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/262:40 pm
DSM
- STL
1 stop3h 15m
Southwest
Wed 9/26:30 am
STL
- DSM
1 stop5h 20m
Southwest
Deal found 7/11![Southwest logo]()
$209
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1211:19 am
OMA
- STL
1 stop4h 19m
United Airlines
Wed 8/198:00 am
STL
- OMA
1 stop6h 04m
United Airlines
Deal found 7/13![United Airlines logo]()
$247
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:40 am
DSM
- STL
1 stop4h 50m
Southwest
Thu 9/36:05 am
STL
- DSM
1 stop5h 20m
Southwest
Deal found 7/13![Southwest logo]()
$209
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/81:54 pm
OMA
- COU
1 stop4h 03m
American Airlines
Tue 8/187:00 am
COU
- OMA
1 stop4h 19m
American Airlines
Deal found 7/12![American Airlines logo]()
$268
This United Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:00 am
DSM
- STL
1 stop4h 11m
United Airlines
Thu 8/66:00 am
STL
- DSM
1 stop4h 17m
United Airlines
Deal found 7/10![United Airlines logo]()
$247
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:10 am
DSM
- STL
2 stops7h 45m
Southwest
Tue 8/186:30 am
STL
- DSM
1 stop5h 20m
Southwest
Deal found 7/14![Southwest logo]()
$214
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:00 am
CID
- MCI
1 stop3h 40m
American Airlines
Wed 8/195:00 am
MCI
- CID
1 stop6h 26m
American Airlines
Deal found 7/15![American Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:40 pm
DSM
- STL
2 stops7h 30m
Southwest
Wed 8/1910:15 am
STL
- DSM
2 stops11h 40m
Southwest
Deal found 7/14![Southwest logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/712:06 pm
OMA
- SGF
2 stops28h 41m
Allegiant Air
Thu 8/138:04 pm
SGF
- OMA
1 stop13h 24m
Allegiant Air
Deal found 7/10![Allegiant Air logo]()
$674
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:48 pm
CID
- MCI
1 stop5h 47m
American Airlines
Sun 8/237:39 pm
MCI
- CID
1 stop4h 39m
American Airlines
Deal found 7/12![American Airlines logo]()
$279
This United Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/173:00 pm
CID
- MCI
1 stop6h 44m
United Airlines
Sun 8/236:36 pm
MCI
- CID
1 stop4h 06m
United Airlines
Deal found 7/12![United Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/98:00 pm
OMA
- MCI
1 stop17h 00m
Frontier
Sun 8/164:32 pm
MCI
- OMA
2 stops26h 43m
Frontier
Deal found 7/10![Frontier logo]()
$358
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:48 pm
CID
- MCI
1 stop5h 47m
American Airlines
Sat 8/157:39 pm
MCI
- CID
1 stop4h 39m
American Airlines
Deal found 7/13![American Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/34:15 pm
OMA
- STL
Nonstop1h 10m
Southwest
Thu 11/510:05 pm
STL
- OMA
Nonstop1h 20m
Southwest
Deal found 7/14![Southwest logo]()
$237
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:32 pm
OMA
- SGF
1 stop6h 10m
United Airlines
Tue 8/187:30 am
SGF
- OMA
1 stop6h 34m
United Airlines
Deal found 7/14![United Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/98:00 pm
OMA
- MCI
2 stops21h 10m
Multiple Airlines
Sun 8/164:32 pm
MCI
- OMA
1 stop18h 44m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$388
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/128:20 am
OMA
- STL
Nonstop1h 15m
Southwest
Wed 8/198:50 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/13![Southwest logo]()
$237
This United Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:09 am
OMA
- SGF
1 stop4h 34m
United Airlines
Thu 8/131:37 pm
SGF
- OMA
1 stop6h 27m
United Airlines
Deal found 7/10![United Airlines logo]()
$305
This Southwest deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/84:40 pm
OMA
- STL
Nonstop1h 15m
Southwest
Wed 9/98:50 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/11![Southwest logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/78:00 pm
OMA
- MCI
2 stops21h 10m
Frontier
Sun 8/91:45 pm
MCI
- OMA
1 stop5h 30m
Frontier
Deal found 7/10![Frontier logo]()
$435
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/244:50 pm
OMA
- STL
Nonstop1h 15m
Southwest
Mon 8/318:30 am
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/10![Southwest logo]()
$247
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:00 am
OMA
- SGF
1 stop4h 50m
United Airlines
Sun 9/206:37 pm
SGF
- OMA
1 stop4h 27m
United Airlines
Deal found 7/15![United Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:23 pm
OMA
- SGF
1 stop6h 55m
American Airlines
Tue 10/137:58 pm
SGF
- OMA
1 stop4h 27m
American Airlines
Deal found 7/12![American Airlines logo]()
$379
Last-minute flights from Iowa to MissouriDiscover last-minute flight deals from Iowa to Missouri. Data last updated July 15, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to Missouri. Data last updated July 15, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:40 pm
DSM
- STL
2 stops7h 30m
Southwest
Sat 8/85:45 am
STL
- DSM
1 stop5h 45m
Southwest
Deal found 7/11![Southwest logo]()
$244
This United Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:00 am
DSM
- STL
1 stop4h 11m
United Airlines
Thu 8/66:00 am
STL
- DSM
1 stop4h 17m
United Airlines
Deal found 7/10![United Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:19 pm
DSM
- STL
1 stop29h 04m
Frontier
Sun 8/96:34 pm
STL
- DSM
2 stops19h 00m
Frontier
Deal found 7/12![Frontier logo]()
$276
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:40 pm
DSM
- STL
1 stop3h 15m
Southwest
Sun 8/97:30 pm
STL
- DSM
1 stop3h 20m
Southwest
Deal found 7/12![Southwest logo]()
$277
This Frontier deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/68:15 pm
OMA
- STL
1 stop23h 08m
Frontier
Mon 8/108:08 pm
STL
- OMA
1 stop23h 07m
Frontier
Deal found 7/14![Frontier logo]()
$244
This American Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/75:00 am
CID
- MCI
1 stop3h 40m
American Airlines
Fri 8/147:39 pm
MCI
- CID
1 stop4h 39m
American Airlines
Deal found 7/11![American Airlines logo]()
$279
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/81:54 pm
OMA
- COU
1 stop4h 03m
American Airlines
Sun 8/96:41 pm
COU
- OMA
1 stop5h 29m
American Airlines
Deal found 7/12![American Airlines logo]()
$268
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/97:56 pm
DSM
- STL
1 stop4h 02m
American Airlines
Wed 8/126:00 am
STL
- DSM
1 stop3h 56m
American Airlines
Deal found 7/10![American Airlines logo]()
$261
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:40 pm
DSM
- STL
1 stop3h 15m
Southwest
Wed 8/198:35 am
STL
- DSM
1 stop5h 20m
Southwest
Deal found 7/14![Southwest logo]()
$209
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/123:05 pm
OMA
- STL
2 stops7h 05m
Southwest
Wed 8/1912:20 pm
STL
- OMA
1 stop4h 25m
Southwest
Deal found 7/13![Southwest logo]()
$262
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/203:50 pm
DSM
- STL
1 stop6h 15m
Southwest
Mon 8/246:25 am
STL
- DSM
1 stop7h 20m
Southwest
Deal found 7/10![Southwest logo]()
$177
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/244:50 pm
OMA
- STL
Nonstop1h 15m
Southwest
Mon 8/318:30 am
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/10![Southwest logo]()
$237
One-way flights from Iowa to MissouriSearch for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated July 15, 2026.
Search for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated July 15, 2026.
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:25 pm
DSM
- STL
1 stop7h 30m
Southwest
Deal found 7/10![Southwest logo]()
$89
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:55 am
DSM
- STL
1 stop3h 28m
Delta
Deal found 7/13![Delta logo]()
$105
This American Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:49 pm
DSM
- STL
1 stop4h 25m
American Airlines
Deal found 7/11![American Airlines logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/128:00 pm
OMA
- MCI
1 stop17h 00m
Frontier
Deal found 7/15![Frontier logo]()
$114
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/54:40 pm
OMA
- STL
Nonstop1h 15m
Southwest
Deal found 7/12![Southwest logo]()
$119
This Priceline deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:18 pm
OMA
- STL
1 stop4h 55m
Frontier
Deal found 7/14![Frontier logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/108:00 pm
OMA
- STL
1 stop23h 23m
Frontier
Deal found 7/12![Frontier logo]()
$123
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:49 pm
DSM
- STL
1 stop4h 25m
American Airlines
Deal found 7/10![American Airlines logo]()
$124
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:50 pm
OMA
- STL
1 stop5h 26m
Delta
Deal found 7/13![Delta logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/128:41 pm
OMA
- STL
1 stop22h 34m
Frontier
Deal found 7/14![Frontier logo]()
$125
This Frontier deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:18 pm
OMA
- STL
1 stop4h 55m
Frontier
Deal found 7/10![Frontier logo]()
$126
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2211:59 am
OMA
- STL
1 stop6h 06m
American Airlines
Deal found 7/10![American Airlines logo]()
$128
Find flight deals from Iowa to Missouri
Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated July 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $177 (Southwest) |
One-way from | $89 (Southwest) |
Popular in | February |
Cheapest in | May |
Average price | $570 |
Good round-trip deal | $462 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 15, 2026.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 8/25
6:10 am-9:35 am
1 stop3h 25m
Lambert-St Louis
Tue 9/1
2:50 pm-9:00 pm
2 stops6h 10m
$182
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Thu 8/20
5:40 am-3:20 pm
2 stops9h 40m
Lambert-St Louis
Mon 8/24
3:45 pm-10:10 pm
2 stops6h 25m
$187
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 8/26
2:40 pm-5:55 pm
1 stop3h 15m
Lambert-St Louis
Wed 9/2
6:30 am-11:50 am
1 stop5h 20m
$209
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Thu 8/27
5:40 am-10:30 am
1 stop4h 50m
Lambert-St Louis
Thu 9/3
6:05 am-11:25 am
1 stop5h 20m
$209
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 8/12
6:10 am-1:55 pm
2 stops7h 45m
Lambert-St Louis
Tue 8/18
6:30 am-11:50 am
1 stop5h 20m
$214
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Sat 8/8
6:00 am-12:11 pm
1 stop6h 11m
Lambert-St Louis
Sat 8/15
8:00 am-12:18 pm
1 stop4h 18m
$219
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 8/12
2:40 pm-10:10 pm
2 stops7h 30m
Lambert-St Louis
Wed 8/19
10:15 am-9:55 pm
2 stops11h 40m
$219
Quickest round-trip
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Tue 11/3
4:15 pm-5:25 pm
Nonstop1h 10m
Lambert-St Louis
Thu 11/5
10:05 pm-11:25 pm
Nonstop1h 20m
$237
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Wed 8/12
8:20 am-9:35 am
Nonstop1h 15m
Lambert-St Louis
Wed 8/19
8:50 pm-10:05 pm
Nonstop1h 15m
$237
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Tue 9/8
4:40 pm-5:55 pm
Nonstop1h 15m
Lambert-St Louis
Wed 9/9
8:50 pm-10:05 pm
Nonstop1h 15m
$237
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
DSM-STL
OMA-STL
OMA-COU
CID-MCI
OMA-MCI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to Missouri
USIA-USMO
DSM-STL
OMA-STL
OMA-COU
CID-MCI
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated July 15, 2026.
Peruse reviews from past customers who have flown with Southwest and American Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Food
7.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Food
7.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Food
7.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Iowa to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to Missouri by cabin class
Find flights from Iowa to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and Missouri flights
Browse other Iowa and Missouri flight options. Last updated on July 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to Iowa after your stay in Missouri
Iowa to Missouri flights
Consider these flights traveling from Iowa to Missouri.
Top 2 airlines flying from Iowa to Missouri
Discover the top 2 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$107 | Average$250 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$158 | Average$356 | FlexibilityNo cancel fee | On-time71% |