$74+ Cheap flights from Iowa to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Aug 29 — Sep 51
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to Missouri with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Iowa to MissouriExplore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.
Explore the most affordable flight options available from Iowa to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:00 am
DSM
- STL
1 stop4h 02m
United Airlines
Thu 9/38:30 am
STL
- DSM
1 stop5h 46m
United Airlines
Deal found 7/30![United Airlines logo]()
$209
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/82:40 pm
DSM
- STL
1 stop3h 15m
Southwest
Tue 9/153:05 pm
STL
- DSM
2 stops6h 55m
Southwest
Deal found 7/27![Southwest logo]()
$214
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:30 am
DSM
- STL
2 stops7h 05m
Southwest
Sat 8/298:30 am
STL
- DSM
2 stops10h 55m
Southwest
Deal found 7/25![Southwest logo]()
$225
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:40 am
DSM
- STL
1 stop3h 35m
Southwest
Thu 9/176:05 am
STL
- DSM
1 stop5h 20m
Southwest
Deal found 7/27![Southwest logo]()
$232
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:50 pm
OMA
- STL
Nonstop1h 15m
Southwest
Mon 8/248:30 am
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/28![Southwest logo]()
$237
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/34:50 pm
OMA
- STL
Nonstop1h 15m
Southwest
Sun 9/66:50 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/28![Southwest logo]()
$242
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:25 am
DSM
- STL
2 stops8h 40m
Southwest
Thu 11/510:15 am
STL
- DSM
2 stops12h 45m
Southwest
Deal found 7/28![Southwest logo]()
$248
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:10 am
OMA
- STL
1 stop4h 13m
Delta
Mon 8/245:34 pm
STL
- OMA
1 stop5h 24m
Delta
Deal found 7/28![Delta logo]()
$248
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/47:49 pm
DSM
- STL
1 stop4h 25m
American Airlines
Mon 9/76:00 am
STL
- DSM
1 stop4h 00m
American Airlines
Deal found 7/28![American Airlines logo]()
$253
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:05 pm
OMA
- STL
1 stop5h 36m
American Airlines
Sun 9/66:36 am
STL
- OMA
1 stop4h 43m
American Airlines
Deal found 7/26![American Airlines logo]()
$257
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:40 am
DSM
- STL
1 stop3h 35m
Southwest
Fri 9/186:15 pm
STL
- DSM
1 stop4h 00m
Southwest
Deal found 7/28![Southwest logo]()
$258
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/172:15 pm
OMA
- STL
1 stop4h 55m
Southwest
Mon 8/178:45 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/27![Southwest logo]()
$259
Best flights from Iowa to MissouriDiscover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2026.
Discover carefully curated flight deals from Iowa to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2026.
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:10 am
DSM
- STL
1 stop3h 25m
Southwest
Tue 9/156:30 am
STL
- DSM
1 stop5h 20m
Southwest
Deal found 7/25![Southwest logo]()
$209
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:00 am
DSM
- STL
1 stop5h 55m
American Airlines
Sat 8/298:06 pm
STL
- DSM
1 stop4h 29m
American Airlines
Deal found 7/25![American Airlines logo]()
$209
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:00 am
DSM
- STL
1 stop3h 23m
Delta
Thu 9/176:15 am
STL
- DSM
1 stop4h 02m
Delta
Deal found 7/28![Delta logo]()
$209
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/83:22 pm
DSM
- STL
1 stop6h 38m
United Airlines
Tue 9/158:00 am
STL
- DSM
1 stop6h 20m
United Airlines
Deal found 7/27![United Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:00 am
DSM
- MCI
2 stops26h 41m
Multiple Airlines
Thu 9/31:38 pm
MCI
- DSM
1 stop23h 56m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/138:41 pm
OMA
- MCI
1 stop13h 44m
Frontier
Wed 9/168:32 pm
MCI
- OMA
1 stop22h 02m
Frontier
Deal found 7/26![Frontier logo]()
$407
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:10 am
DSM
- STL
1 stop3h 25m
Southwest
Tue 9/12:50 pm
STL
- DSM
2 stops6h 10m
Southwest
Deal found 7/28![Southwest logo]()
$214
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:30 am
DSM
- STL
2 stops7h 05m
Southwest
Sat 9/198:25 am
STL
- DSM
1 stop3h 05m
Southwest
Deal found 7/29![Southwest logo]()
$214
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:30 am
DSM
- STL
2 stops7h 05m
Southwest
Sat 8/298:25 am
STL
- DSM
1 stop3h 05m
Southwest
Deal found 7/25![Southwest logo]()
$214
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:06 am
CID
- MCI
1 stop6h 12m
United Airlines
Sun 8/236:36 pm
MCI
- CID
1 stop4h 06m
United Airlines
Deal found 7/26![United Airlines logo]()
$289
This Delta deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:20 am
CID
- MCI
1 stop3h 27m
Delta
Sun 10/116:30 am
MCI
- CID
1 stop3h 42m
Delta
Deal found 7/25![Delta logo]()
$289
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:20 am
OMA
- SGF
1 stop4h 37m
American Airlines
Wed 8/268:04 pm
SGF
- OMA
1 stop4h 06m
American Airlines
Deal found 7/28![American Airlines logo]()
$300
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:40 am
DSM
- STL
1 stop3h 35m
Southwest
Thu 9/176:05 am
STL
- DSM
1 stop5h 20m
Southwest
Deal found 7/27![Southwest logo]()
$232
This Delta deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:39 am
CID
- MCI
1 stop4h 51m
Delta
Sun 9/206:20 am
MCI
- CID
1 stop5h 02m
Delta
Deal found 7/25![Delta logo]()
$289
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1111:59 am
OMA
- COU
1 stop4h 48m
American Airlines
Sat 8/157:00 am
COU
- OMA
1 stop4h 19m
American Airlines
Deal found 7/27![American Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/122:15 pm
OMA
- STL
Nonstop1h 20m
Southwest
Mon 9/148:30 am
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/27![Southwest logo]()
$237
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/285:32 pm
OMA
- SGF
1 stop6h 10m
United Airlines
Sat 8/297:30 am
SGF
- OMA
1 stop5h 02m
United Airlines
Deal found 7/29![United Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:55 am
OMA
- COU
1 stop5h 18m
American Airlines
Tue 8/186:41 pm
COU
- OMA
1 stop5h 29m
American Airlines
Deal found 7/29![American Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:00 am
OMA
- SGF
1 stop4h 37m
United Airlines
Thu 9/35:30 am
SGF
- OMA
1 stop7h 14m
United Airlines
Deal found 7/28![United Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/34:50 pm
OMA
- STL
Nonstop1h 15m
Southwest
Sun 9/66:50 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/26![Southwest logo]()
$242
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:05 pm
OMA
- COU
1 stop5h 23m
American Airlines
Sun 8/167:00 am
COU
- OMA
1 stop4h 19m
American Airlines
Deal found 7/28![American Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:15 am
OMA
- STL
Nonstop1h 15m
Southwest
Mon 8/3111:05 am
STL
- OMA
1 stop5h 05m
Southwest
Deal found 7/25![Southwest logo]()
$247
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/231:45 pm
OMA
- COU
1 stop6h 45m
United Airlines
Wed 1/275:00 am
COU
- OMA
1 stop7h 16m
United Airlines
Deal found 7/27![United Airlines logo]()
$348
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:00 am
CID
- MCI
1 stop3h 40m
American Airlines
Sat 8/157:39 pm
MCI
- CID
1 stop4h 39m
American Airlines
Deal found 7/27![American Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:10 am
OMA
- STL
Nonstop1h 15m
Southwest
Mon 8/246:25 am
STL
- OMA
1 stop6h 55m
Southwest
Deal found 7/30![Southwest logo]()
$247
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:00 am
OMA
- SGF
1 stop4h 37m
United Airlines
Mon 8/175:05 pm
SGF
- OMA
1 stop6h 37m
United Airlines
Deal found 7/28![United Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:48 pm
CID
- MCI
1 stop5h 22m
American Airlines
Mon 8/177:39 pm
MCI
- CID
1 stop4h 39m
American Airlines
Deal found 7/29![American Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/164:40 pm
OMA
- STL
Nonstop1h 15m
Southwest
Wed 9/237:00 am
STL
- OMA
1 stop6h 40m
Southwest
Deal found 7/25![Southwest logo]()
$247
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:25 am
CID
- MCI
1 stop4h 41m
United Airlines
Mon 8/316:36 pm
MCI
- CID
1 stop4h 06m
United Airlines
Deal found 7/27![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:05 pm
OMA
- SGF
1 stop4h 24m
American Airlines
Tue 8/187:15 am
SGF
- OMA
1 stop6h 09m
American Airlines
Deal found 7/30![American Airlines logo]()
$329
Last-minute flights from Iowa to MissouriDiscover last-minute flight deals from Iowa to Missouri. Data last updated July 30, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to Missouri. Data last updated July 30, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/172:15 pm
OMA
- STL
1 stop4h 55m
Southwest
Mon 8/178:45 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/27![Southwest logo]()
$259
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:06 am
CID
- MCI
1 stop6h 12m
United Airlines
Sun 8/236:36 pm
MCI
- CID
1 stop4h 06m
United Airlines
Deal found 7/26![United Airlines logo]()
$289
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:50 pm
OMA
- STL
Nonstop1h 15m
Southwest
Mon 8/248:30 am
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/28![Southwest logo]()
$237
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:10 am
OMA
- STL
1 stop4h 13m
Delta
Mon 8/245:34 pm
STL
- OMA
1 stop5h 24m
Delta
Deal found 7/28![Delta logo]()
$248
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:49 pm
DSM
- STL
1 stop4h 25m
American Airlines
Sun 8/305:00 am
STL
- DSM
1 stop4h 56m
American Airlines
Deal found 7/28![American Airlines logo]()
$282
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:40 am
DSM
- STL
1 stop3h 35m
Southwest
Sun 8/303:20 pm
STL
- DSM
2 stops7h 30m
Southwest
Deal found 7/28![Southwest logo]()
$292
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:30 am
DSM
- STL
2 stops7h 05m
Southwest
Sat 8/298:25 am
STL
- DSM
1 stop3h 05m
Southwest
Deal found 7/25![Southwest logo]()
$214
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:10 am
DSM
- STL
2 stops8h 15m
Southwest
Tue 9/12:50 pm
STL
- DSM
2 stops6h 10m
Southwest
Deal found 7/28![Southwest logo]()
$219
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:00 am
DSM
- STL
1 stop4h 02m
United Airlines
Thu 9/38:30 am
STL
- DSM
1 stop5h 46m
United Airlines
Deal found 7/30![United Airlines logo]()
$209
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:40 am
DSM
- STL
1 stop4h 50m
Southwest
Thu 9/311:40 am
STL
- DSM
2 stops10h 35m
Southwest
Deal found 7/30![Southwest logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:18 pm
OMA
- MCI
1 stop22h 35m
Frontier
Thu 9/31:38 pm
MCI
- OMA
1 stop23h 55m
Frontier
Deal found 7/29![Frontier logo]()
$278
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/284:50 pm
OMA
- STL
Nonstop1h 15m
Southwest
Fri 9/42:55 pm
STL
- OMA
Nonstop1h 15m
Southwest
Deal found 7/29![Southwest logo]()
$277
One-way flights from Iowa to MissouriSearch for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated July 30, 2026.
Search for one-way flight options from Iowa to Missouri. Find affordable one-way fares based on user searches. Data last updated July 30, 2026.
This Frontier deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:18 pm
OMA
- STL
1 stop4h 55m
Frontier
Deal found 7/30![Frontier logo]()
$74
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/297:56 pm
DSM
- STL
1 stop4h 02m
American Airlines
Deal found 7/29![American Airlines logo]()
$105
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:30 am
DSM
- STL
2 stops7h 05m
Southwest
Deal found 7/29![Southwest logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:29 pm
OMA
- STL
1 stop23h 48m
Frontier
Deal found 7/29![Frontier logo]()
$116
This Frontier deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:18 pm
OMA
- STL
1 stop4h 55m
Frontier
Deal found 7/30![Frontier logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/302:18 pm
OMA
- STL
1 stop28h 55m
Frontier
Deal found 7/29![Frontier logo]()
$118
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:15 am
OMA
- STL
Nonstop1h 15m
Southwest
Deal found 7/25![Southwest logo]()
$119
This Frontier deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:18 pm
OMA
- STL
1 stop4h 55m
Frontier
Deal found 7/25![Frontier logo]()
$123
This Delta deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:05 am
OMA
- STL
1 stop6h 42m
Delta
Deal found 7/25![Delta logo]()
$124
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:20 pm
OMA
- STL
1 stop3h 50m
Southwest
Deal found 7/25![Southwest logo]()
$129
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/274:50 pm
OMA
- STL
Nonstop1h 15m
Southwest
Deal found 7/28![Southwest logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:05 pm
DSM
- STL
2 stops18h 16m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$132
Find flight deals from Iowa to Missouri
Keep the following information in mind while searching for Iowa to Missouri flight deals. Data was last updated July 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $209 (United Airlines) |
One-way from | $74 (Frontier) |
Popular in | February |
Cheapest in | May |
Average price | $570 |
Good round-trip deal | $462 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
Use the filters below to find and compare flights from Iowa to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 9/8
6:10 am-9:35 am
1 stop3h 25m
Lambert-St Louis
Tue 9/15
6:30 am-11:50 am
1 stop5h 20m
$209
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Sat 8/22
7:00 am-12:55 pm
1 stop5h 55m
Lambert-St Louis
Sat 8/29
8:06 pm-12:35 am
1 stop4h 29m
$209
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Thu 9/10
7:00 am-10:23 am
1 stop3h 23m
Lambert-St Louis
Thu 9/17
6:15 am-10:17 am
1 stop4h 02m
$209
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 9/8
3:22 pm-10:00 pm
1 stop6h 38m
Lambert-St Louis
Tue 9/15
8:00 am-2:20 pm
1 stop6h 20m
$209
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 8/25
6:10 am-9:35 am
1 stop3h 25m
Lambert-St Louis
Tue 9/1
2:50 pm-9:00 pm
2 stops6h 10m
$214
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Sat 9/12
5:30 am-12:35 pm
2 stops7h 05m
Lambert-St Louis
Sat 9/19
8:25 am-11:30 am
1 stop3h 05m
$214
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Sat 8/22
5:30 am-12:35 pm
2 stops7h 05m
Lambert-St Louis
Sat 8/29
8:25 am-11:30 am
1 stop3h 05m
$214
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Thu 9/10
5:40 am-9:15 am
1 stop3h 35m
Lambert-St Louis
Thu 9/17
6:05 am-11:25 am
1 stop5h 20m
$232
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Sat 9/12
2:15 pm-3:35 pm
Nonstop1h 20m
Lambert-St Louis
Mon 9/14
8:30 am-9:45 am
Nonstop1h 15m
$237
Quickest round-trip
OmahaSt. Louis
OMA - STL
OMASTL
Omaha Eppley Airfield
Thu 9/3
4:50 pm-6:05 pm
Nonstop1h 15m
Lambert-St Louis
Sun 9/6
6:50 pm-8:05 pm
Nonstop1h 15m
$242
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Iowa with our price prediction graph.
DSM-STL
OMA-STL
CID-MCI
DSM-MCI
OMA-MCI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to Missouri
USIA-USMO
DSM-STL
OMA-STL
CID-MCI
DSM-MCI
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated July 30, 2026.
Peruse reviews from past customers who have flown with Southwest and American Airlines from Iowa to Missouri to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Iowa to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Iowa to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to Missouri by cabin class
Find flights from Iowa to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and Missouri flights
Browse other Iowa and Missouri flight options. Last updated on July 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to Iowa after your stay in Missouri
Iowa to Missouri flights
Consider these flights traveling from Iowa to Missouri.
Top 2 airlines flying from Iowa to Missouri
Discover the top 2 airlines that operate flights from Iowa to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$107 | Average$250 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$158 | Average$362 | FlexibilityNo cancel fee | On-time71% |