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$250+ Cheap flights from Florence, SC (FLO) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/1. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — STL
Apr 22 — Apr 291
Wed 4/22
Wed 4/29
1 adult, Economy
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Cheap flight deals from Florence to Missouri

Cheapest flights from Florence to Missouri
Explore the most affordable flight options available from Florence to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.

This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/222:35 pm
FLO
-
STL
1 stop5h 25m
American Airlines
Mon 5/256:00 am
STL
-
FLO
2 stops7h 10m
American Airlines
Deal found 3/23$366
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/74:02 pm
FLO
-
STL
1 stop4h 28m
American Airlines
Sat 4/112:12 pm
STL
-
FLO
1 stop6h 35m
American Airlines
Deal found 3/23$385
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/56:20 pm
FLO
-
MCI
1 stop6h 39m
American Airlines
Sat 4/112:11 pm
MCI
-
FLO
1 stop6h 36m
American Airlines
Deal found 3/20$560
This American Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:20 pm
FLO
-
MCI
1 stop6h 39m
American Airlines
Tue 4/73:11 pm
MCI
-
FLO
1 stop6h 31m
American Airlines
Deal found 3/18$566
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:20 pm
FLO
-
SGF
1 stop4h 39m
American Airlines
Tue 4/77:10 am
SGF
-
FLO
1 stop7h 22m
American Airlines
Deal found 3/19$619

Find flight deals from Florence to Missouri

Keep the following information in mind while searching for Florence to Missouri flight deals. Data was last updated March 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$366
(American Airlines)

One-way from

$250
(American Airlines)
Provider with most accurate pricing for Florence-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-Lambert-St Louis flights.
Search Deals
From Florence to Missouri
Search Deals
One-way flight from Florence to Missouri
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Florence to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Fri 5/22

2:35 pm-7:00 pm

1 stop5h 25m

Lambert-St Louis

Mon 5/25

6:00 am-2:10 pm

2 stops7h 10m

$366
Quickest round-trip

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Tue 4/7

4:02 pm-7:30 pm

1 stop4h 28m

Lambert-St Louis

Sat 4/11

2:12 pm-9:47 pm

1 stop6h 35m

$385

FlorenceKansas City

FLO - MCI

FLOMCI

Florence

Sun 4/5

6:20 pm-11:59 pm

1 stop6h 39m

Kansas City

Sat 4/11

2:11 pm-9:47 pm

1 stop6h 36m

$560

FlorenceKansas City

FLO - MCI

FLOMCI

Florence

Fri 4/3

6:20 pm-11:59 pm

1 stop6h 39m

Kansas City

Tue 4/7

3:11 pm-10:42 pm

1 stop6h 31m

$566

FlorenceSpringfield

FLO - SGF

FLOSGF

Florence

Fri 4/3

6:20 pm-9:59 pm

1 stop4h 39m

Springfield-Branson

Tue 4/7

7:10 am-3:32 pm

1 stop7h 22m

$619
Cheapest one-way
Quickest one-way

FlorenceKansas City

FLO - MCI

FLOMCI

Florence

Tue 9/1

11:15 am-2:59 pm

1 stop4h 44m

$250

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/18

Sorted by cheapest first

Best time to book a flight from Florence to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Missouri

What is the cheapest month to book a flight from Florence, South Carolina to Missouri?

Currently, December is the cheapest month in which you can book a flight from Florence, South Carolina to Missouri (average of $118). Flying from Florence, South Carolina to Missouri in February is currently the most expensive (average of $245). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Missouri?

    Located just 2.3 mi from the city center, Florence (FLO) is the airport most travelers will use when flying to Missouri from Florence.

  • How long is the flight from Florence, South Carolina to Missouri?

    Airlines like American Airlines fly from Florence, South Carolina to Missouri in about 5h 25m. The time it takes to get you to your destination can typically vary by up to . There are 669 mi between Florence, South Carolina and Missouri.

  • What are the most popular routes from Florence, South Carolina to Missouri?

    While some choose either Florence - Kansas City or Florence - Springfield-Branson, Florence - Joplin is the most popular route from Florence, South Carolina to Missouri.

  • Can I find deals for flights from Florence to Missouri that include hotel bookings?

    Yes. In addition to deals on Florence to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Missouri.

  • Can I find deals for business class flights from Florence to Missouri?

    Yes. Cheapflights offers flight deals from Florence to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Missouri?

    Currently, December is the cheapest month in which you can book a flight from Florence, South Carolina to Missouri (average of $118). Flying from Florence, South Carolina to Missouri in February is currently the most expensive (average of $245). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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