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Mississippi

$164+ Cheap flights from Des Moines (DSM) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
Apr 11 — Apr 181
Sat 4/11
Sat 4/18
1 adult, Economy
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Cheap flight deals from Des Moines to Mississippi

Cheapest flights from Des Moines to Mississippi
Explore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.

This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:55 am
DSM
-
MEM
1 stop7h 25m
Southwest
Tue 4/146:35 am
MEM
-
DSM
1 stop7h 30m
Southwest
Deal found 3/10$271
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:20 pm
DSM
-
MOB
1 stop6h 08m
Delta
Wed 4/86:15 am
MOB
-
DSM
1 stop4h 33m
Delta
Deal found 3/9$289
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:20 pm
DSM
-
MEM
1 stop7h 05m
Southwest
Thu 4/304:10 pm
MEM
-
DSM
1 stop6h 55m
Southwest
Deal found 3/9$291
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:40 am
DSM
-
MEM
2 stops7h 20m
Southwest
Sat 5/25:00 am
MEM
-
DSM
1 stop6h 30m
Southwest
Deal found 3/11$296
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:05 am
DSM
-
GPT
1 stop5h 08m
American Airlines
Sat 3/285:00 am
GPT
-
DSM
1 stop5h 44m
American Airlines
Deal found 3/9$299
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1411:09 am
DSM
-
MOB
2 stops11h 42m
American Airlines
Sat 4/185:10 am
MOB
-
DSM
2 stops8h 36m
American Airlines
Deal found 3/9$300
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:45 am
DSM
-
MOB
1 stop5h 44m
Delta
Wed 10/76:00 am
MOB
-
DSM
1 stop4h 18m
Delta
Deal found 3/9$309
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:20 pm
DSM
-
MEM
1 stop7h 00m
Southwest
Fri 4/105:05 am
MEM
-
DSM
1 stop6h 40m
Southwest
Deal found 3/7$309
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/58:20 am
DSM
-
MOB
1 stop8h 00m
United Airlines
Sat 4/114:55 pm
MOB
-
DSM
1 stop5h 48m
United Airlines
Deal found 3/8$319
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/271:52 pm
DSM
-
BTR
1 stop7h 44m
American Airlines
Tue 3/317:08 am
BTR
-
DSM
1 stop5h 59m
American Airlines
Deal found 3/11$319
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/253:20 pm
DSM
-
JAN
1 stop7h 37m
American Airlines
Sat 5/21:28 pm
JAN
-
DSM
1 stop7h 59m
American Airlines
Deal found 3/11$319
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:30 pm
DSM
-
MOB
1 stop4h 25m
Delta
Thu 8/136:00 am
MOB
-
DSM
1 stop4h 14m
Delta
Deal found 3/8$324

Find flight deals from Des Moines to Mississippi

Keep the following information in mind while searching for Des Moines to Mississippi flight deals. Data was last updated March 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$271
(Southwest)

One-way from

$164
(Delta)
Provider with most accurate pricing for Des Moines-Jackson-Evers Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Jackson-Evers Intl flights.
Search Deals
From Des Moines to Mississippi
Search Deals
One-way flight from Des Moines to Mississippi
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
Use the filters below to find and compare flights from Des Moines to Mississippi that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Tue 3/24

5:05 am-10:13 am

1 stop5h 08m

Gulfport Biloxi Regional

Sat 3/28

5:00 am-10:44 am

1 stop5h 44m

$299
Quickest round-trip

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Sun 8/30

6:30 pm-10:55 pm

1 stop4h 25m

Mobile

Sun 9/6

6:00 am-10:14 am

1 stop4h 14m

$309

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 4/6

4:20 pm-11:20 pm

1 stop7h 00m

Memphis

Fri 4/10

5:05 am-11:45 am

1 stop6h 40m

$309

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Wed 5/13

11:55 am-7:18 pm

1 stop7h 23m

Memphis

Sun 5/17

6:00 am-12:24 pm

1 stop6h 24m

$309

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Sun 4/5

8:20 am-4:20 pm

1 stop8h 00m

Mobile

Sat 4/11

4:55 pm-10:43 pm

1 stop5h 48m

$319

Des MoinesBaton Rouge

DSM - BTR

DSMBTR

Des Moines

Fri 3/27

1:52 pm-9:36 pm

1 stop7h 44m

Baton Rouge Ryan

Tue 3/31

4:28 pm-11:48 pm

2 stops7h 20m

$324

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 4/24

4:20 pm-11:25 pm

1 stop7h 05m

Memphis

Fri 5/1

5:05 am-11:45 am

1 stop6h 40m

$327

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sat 4/18

9:00 am-2:24 pm

1 stop5h 24m

Memphis

Tue 4/21

7:30 am-12:29 pm

1 stop4h 59m

$331

Des MoinesBaton Rouge

DSM - BTR

DSMBTR

Des Moines

Thu 5/28

6:20 am-11:20 am

1 stop5h 00m

Baton Rouge Ryan

Tue 6/2

4:09 pm-10:35 pm

1 stop6h 26m

$344

Des MoinesAlexandria

DSM - AEX

DSMAEX

Des Moines

Tue 3/24

5:05 am-9:33 am

1 stop4h 28m

Alexandria

Sat 3/28

6:28 pm-11:46 pm

1 stop5h 18m

$348

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/10

Showing 1-10 of 36 resultsSorted by cheapest first
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Best time to book a flight from Des Moines to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mississippi

What is the cheapest month to book a flight from Des Moines to Mississippi?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $248). Flying from Des Moines to Mississippi in March is currently the most expensive (average of $424). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated March 12, 2026.
Peruse reviews from past customers who have flown with American Airlines from Des Moines to Mississippi to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,432 reviews

Crew

7.9

Overall

7.1

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes
American Airlines
7.1
Good
11,432 reviews
American Airlines
7.1
Good
11,432 reviews

Crew

7.9

Overall

7.1

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mississippi?

    If you book a flight to Mississippi from Des Moines, you will be flying from Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • How long is the flight from Des Moines to Mississippi?

    A quick flight from Des Moines to Mississippi can take about 4h 25m. American Airlines provides one of the quickest options available for as low as $309. Des Moines and Mississippi are separated by a distance of 807 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Des Moines to Mississippi?

    When deciding which route to take from Des Moines to Mississippi consider Des Moines - Mobile, Des Moines - Gulfport Biloxi Regional or Des Moines - Baton Rouge Ryan as they are the most popular.

  • Can I find deals for flights from Des Moines to Mississippi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mississippi.

  • Can I find deals for business class flights from Des Moines to Mississippi?

    Yes. Cheapflights offers flight deals from Des Moines to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mississippi?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $248). Flying from Des Moines to Mississippi in March is currently the most expensive (average of $424). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Omaha to Tampa flights
Moline to Tampa flights
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Cedar Rapids to Fort Myers flights
Omaha to Baltimore flights

Top airline flying from Des Moines to Mississippi

Discover the top airline that operate flights from Des Moines to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$502FlexibilityNo cancel feeOn-time71%

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