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$125+ Cheap flights from Des Moines (DSM) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/9. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Des Moines to Mississippi

Keep the following information in mind while searching for Des Moines to Mississippi flight deals. Data was last updated June 12, 2025.

Round-trip from

$246
(United Airlines)

One-way from

$125
(American Airlines)
From Des Moines to Mississippi
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One-way flight from Des Moines to Mississippi
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Find flight deals from Des Moines to Mississippi

Cheapest flights from Des Moines to Mississippi
Explore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/262:58 pmDSM - MEM
1 stop6h 39mUnited Airlines
Wed 8/277:30 amMEM - DSM
1 stop4h 53mUnited Airlines
Deal found 6/10$246
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/112:29 pmDSM - BTR
1 stop7h 29mDelta
Mon 7/143:21 pmBTR - DSM
1 stop7h 12mDelta
Deal found 6/12$249
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/166:30 pmDSM - MOB
1 stop4h 28mDelta
Tue 9/304:15 pmMOB - DSM
1 stop6h 08mDelta
Deal found 6/12$249
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/165:34 pmDSM - GPT
1 stop5h 36mAmerican Airlines
Mon 9/296:29 pmGPT - DSM
1 stop4h 44mAmerican Airlines
Deal found 6/12$249
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/185:29 pmDSM - MEM
1 stop5h 31mAmerican Airlines
Sat 8/232:13 pmMEM - DSM
1 stop7h 24mAmerican Airlines
Deal found 6/11$251
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/95:00 amDSM - MOB
2 stops11h 10mAmerican Airlines
Sun 7/134:35 pmMOB - DSM
1 stop6h 26mAmerican Airlines
Deal found 6/11$254
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1610:15 amDSM - GPT
2 stops11h 51mDelta
Tue 9/306:00 pmGPT - DSM
1 stop4h 23mDelta
Deal found 6/12$254
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/268:25 amDSM - MEM
2 stops9h 00mSouthwest
Wed 8/273:30 pmMEM - DSM
2 stops6h 50mSouthwest
Deal found 6/10$261
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/79:30 amDSM - MEM
1 stop21h 46mAllegiant Air
Thu 7/108:48 pmMEM - DSM
1 stop11h 52mAllegiant Air
Deal found 6/11$272
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/103:59 pmDSM - BTR
1 stop4h 41mAmerican Airlines
Sun 7/1312:56 pmBTR - DSM
1 stop6h 11mAmerican Airlines
Deal found 6/12$274
This Mytrip deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/276:30 amDSM - MEM
1 stop11h 01mMultiple Airlines
Tue 7/17:45 pmMEM - DSM
1 stop15h 50mMultiple Airlines
Deal found 6/12$283
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/122:57 pmDSM - GPT
1 stop6h 47mUnited Airlines
Fri 7/185:25 pmGPT - DSM
1 stop4h 52mUnited Airlines
Deal found 6/11$306

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Des Moines to Mississippi that are best for you.

Fly from

Des Moines

Fly to

Mississippi

Route

Depart

Return

Price

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Tue 8/26

2:58 pm-9:37 pm

1 stop6h 39m

Memphis

Wed 8/27

7:30 am-12:23 pm

1 stop4h 53m

$246

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Tue 9/16

6:30 pm-10:58 pm

1 stop4h 28m

Mobile

Tue 9/30

4:15 pm-10:23 pm

1 stop6h 08m

$249

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Tue 9/16

5:34 pm-11:10 pm

1 stop5h 36m

Gulfport Biloxi Regional

Mon 9/29

6:29 pm-11:13 pm

1 stop4h 44m

$249

Des MoinesBaton Rouge

DSM - BTR

DSMBTR

Des Moines

Fri 7/11

2:29 pm-9:58 pm

1 stop7h 29m

Baton Rouge Ryan

Mon 7/14

3:21 pm-10:33 pm

1 stop7h 12m

$249

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 8/18

5:29 pm-11:00 pm

1 stop5h 31m

Memphis

Sat 8/23

2:13 pm-9:37 pm

1 stop7h 24m

$251

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Wed 7/9

5:00 am-4:10 pm

2 stops11h 10m

Mobile

Sun 7/13

4:35 pm-11:01 pm

1 stop6h 26m

$254

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Tue 9/16

10:15 am-10:06 pm

2 stops11h 51m

Gulfport Biloxi Regional

Sat 9/27

6:00 am-10:18 am

1 stop4h 18m

$254

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Tue 8/26

8:25 am-5:25 pm

2 stops9h 00m

Memphis

Wed 8/27

3:30 pm-10:20 pm

2 stops6h 50m

$261

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 7/7

9:30 am-7:16 am

1 stop21h 46m

Memphis

Thu 7/10

8:48 pm-8:40 am

1 stop11h 52m

$272

Des MoinesBaton Rouge

DSM - BTR

DSMBTR

Des Moines

Thu 7/10

3:59 pm-8:40 pm

1 stop4h 41m

Baton Rouge Ryan

Sun 7/13

12:56 pm-7:07 pm

1 stop6h 11m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Showing 1-10 of 31 results
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Best time to book a flight from Des Moines to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mississippi

What is the cheapest month to book a flight from Des Moines to Mississippi?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $371). Flying from Des Moines to Mississippi in March is currently the most expensive (average of $448). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Mississippi by month

Plan your trip to Mississippi by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Mississippi ranges from 2.2 - 5.6 inches per month. December is typically the wettest month, when rainfall can reach 5.6 in. October is typically the driest time to visit Mississippi when rainfall is around 2.2 in.

Temperature in Mississippi by month

Plan your trip to Mississippi by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Mississippi, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 82.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 48.2 F).

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated June 12, 2025.
To help decide which airline to fly from Des Moines to Mississippi, see what other customers have to say about Southwest, Delta and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,287 reviews

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Food

7.1

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,287 reviews
Southwest
8.0
Very good
4,287 reviews

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Food

7.1

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,950 reviews
Southwest
8.0
Very good
4,287 reviews

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Food

7.1

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,790 reviews
Southwest
8.0
Very good
4,287 reviews

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Food

7.1

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Allegiant Air
7.3
Good
725 reviews
Southwest
8.0
Very good
4,287 reviews

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Food

7.1

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,287 reviews

Entertainment

7.6

Boarding

8.2

Comfort

8.0

Food

7.1

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mississippi?

    If you book a flight to Mississippi from Des Moines, you will be flying from Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • What are the cheapest airlines to fly from Des Moines to Mississippi one-way?

    The cheapest airlines for a one-way flight from Des Moines to Mississippi are American Airlines ($125), Allegiant Air ($154), and Southwest ($199).

  • What are the most popular routes from Des Moines to Mississippi?

    When deciding which route to take from Des Moines to Mississippi consider Des Moines - Mobile, Des Moines - Memphis or Des Moines - Gulfport Biloxi Regional as they are the most popular.

  • Can I find deals for flights from Des Moines to Mississippi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mississippi.

  • Can I find deals for business class flights from Des Moines to Mississippi?

    Yes. Cheapflights offers flight deals from Des Moines to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mississippi?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $371). Flying from Des Moines to Mississippi in March is currently the most expensive (average of $448). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Des Moines to Mississippi

Discover the top 2 airlines that operate flights from Des Moines to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$334FlexibilityNo cancel feeOn-time71%
DeltaCheapest$263Average$353FlexibilityNo cancel feeOn-timeN/A

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