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$163+ Cheap flights from Des Moines (DSM) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/8. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Des Moines to Mississippi

Cheapest flights from Des Moines to Mississippi
Explore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:55 pmDSM - MEM
1 stop4h 26mDelta
Mon 12/295:55 amMEM - DSM
1 stop5h 33mDelta
Deal found 12/10$318
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/252:07 pmDSM - MEM
1 stop5h 32mAmerican Airlines
Mon 12/295:00 amMEM - DSM
2 stops7h 54mAmerican Airlines
Deal found 12/11$323
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:31 amDSM - MEM
2 stops34h 36mMultiple Airlines
Tue 12/308:47 pmMEM - DSM
1 stop16h 08mMultiple Airlines
Deal found 12/11$348
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:40 amDSM - BTR
2 stops7h 08mAmerican Airlines
Mon 12/295:53 pmBTR - DSM
1 stop5h 42mAmerican Airlines
Deal found 12/10$365
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:31 amDSM - MEM
2 stops34h 36mMultiple Airlines
Mon 12/295:54 pmMEM - DSM
1 stop21h 37mMultiple Airlines
Deal found 12/11$367
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/252:07 pmDSM - MEM
1 stop5h 32mAmerican Airlines
Sun 12/287:04 amMEM - DSM
1 stop5h 50mAmerican Airlines
Deal found 12/11$378
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:31 amDSM - MEM
2 stops34h 36mMultiple Airlines
Sun 12/288:17 pmMEM - DSM
1 stop13h 46mMultiple Airlines
Deal found 12/11$384
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:30 amDSM - BTR
2 stops10h 17mUnited Airlines
Mon 12/295:10 amBTR - DSM
2 stops9h 23mUnited Airlines
Deal found 12/10$389
This American Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:39 pmDSM - AEX
1 stop4h 59mAmerican Airlines
Mon 12/295:44 amAEX - DSM
1 stop5h 05mAmerican Airlines
Deal found 12/9$391
This Delta deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:59 amDSM - MEM
1 stop4h 34mDelta
Mon 12/295:55 amMEM - DSM
1 stop5h 33mDelta
Deal found 12/11$407
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:06 pmDSM - MEM
1 stop5h 23mUnited Airlines
Sun 12/287:30 amMEM - DSM
1 stop7h 03mUnited Airlines
Deal found 12/11$408
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:40 amDSM - GPT
2 stops9h 34mAmerican Airlines
Mon 12/295:58 pmGPT - DSM
1 stop5h 37mAmerican Airlines
Deal found 12/10$412

Find flight deals from Des Moines to Mississippi

Keep the following information in mind while searching for Des Moines to Mississippi flight deals. Data was last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$240
(Delta)

One-way from

$163
(American Airlines)
Provider with most accurate pricing for Des Moines-Jackson-Evers Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Jackson-Evers Intl flights.
Search Deals
From Des Moines to Mississippi
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One-way flight from Des Moines to Mississippi
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Des Moines to Mississippi that are best for you.

Fly from

Des Moines

Fly to

Mississippi

Route

Depart

Return

Price

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sun 1/18

6:54 am-11:43 am

1 stop4h 49m

Memphis

Thu 1/22

10:32 am-5:08 pm

1 stop6h 36m

$259

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sun 1/18

4:00 pm-10:51 pm

1 stop6h 51m

Memphis

Thu 1/22

8:37 am-4:24 pm

2 stops7h 47m

$264

Des MoinesAlexandria

DSM - AEX

DSMAEX

Des Moines

Tue 1/20

4:00 pm-10:59 pm

1 stop6h 59m

Alexandria

Tue 1/27

6:06 am-10:50 am

1 stop4h 44m

$278

Des MoinesBaton Rouge

DSM - BTR

DSMBTR

Des Moines

Sat 1/17

11:30 am-9:32 pm

2 stops10h 02m

Baton Rouge Ryan

Wed 1/21

9:30 am-8:34 pm

2 stops11h 04m

$309

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 12/25

3:14 pm-9:58 pm

1 stop6h 44m

Memphis

Mon 12/29

2:48 pm-9:40 pm

1 stop6h 52m

$318

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 12/25

6:15 am-11:14 am

1 stop4h 59m

Memphis

Tue 12/30

6:00 am-10:38 am

1 stop4h 38m

$318

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 12/25

5:55 pm-10:21 pm

1 stop4h 26m

Memphis

Mon 12/29

5:55 am-11:28 am

1 stop5h 33m

$318

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sun 1/25

2:58 pm-10:49 am

2 stops19h 51m

Memphis

Sun 2/1

8:18 pm-10:19 am

2 stops14h 01m

$319

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sun 1/18

8:10 am-1:49 pm

1 stop5h 39m

Memphis

Thu 1/22

5:00 pm-10:30 pm

1 stop5h 30m

$319

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 12/25

2:07 pm-7:39 pm

1 stop5h 32m

Memphis

Mon 12/29

5:00 am-12:54 pm

2 stops7h 54m

$323

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 38 results
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Best time to book a flight from Des Moines to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mississippi

What is the cheapest month to book a flight from Des Moines to Mississippi?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $248). Flying from Des Moines to Mississippi in February is currently the most expensive (average of $687). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated December 12, 2025.
Peruse reviews from past customers who have flown with American Airlines from Des Moines to Mississippi to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,050 reviews

Food

6.5

Comfort

7.2

Crew

8.0

Boarding

7.5

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,050 reviews
American Airlines
7.2
Good
11,050 reviews

Food

6.5

Comfort

7.2

Crew

8.0

Boarding

7.5

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mississippi?

    If you book a flight to Mississippi from Des Moines, you will be flying from Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • How long is the flight from Des Moines to Mississippi?

    A quick flight from Des Moines to Mississippi can take about 4h 49m. Delta provides one of the quickest options available for as low as $259. Des Moines and Mississippi are separated by a distance of 491 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Des Moines to Mississippi?

    When deciding which route to take from Des Moines to Mississippi consider Des Moines - Mobile, Des Moines - Memphis or Des Moines - Gulfport Biloxi Regional as they are the most popular.

  • Can I find deals for flights from Des Moines to Mississippi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mississippi.

  • Can I find deals for business class flights from Des Moines to Mississippi?

    Yes. Cheapflights offers flight deals from Des Moines to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mississippi?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $248). Flying from Des Moines to Mississippi in February is currently the most expensive (average of $687). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Des Moines to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Des Moines to Mississippi

Discover the top airline that operate flights from Des Moines to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$308FlexibilityNo cancel feeOn-time71%

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