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Mississippi

$164+ Cheap flights from Des Moines (DSM) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/2. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Des Moines to Mississippi

Cheapest flights from Des Moines to Mississippi
Explore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/241:38 pm
DSM
-
MEM
1 stop7h 48m
American Airlines
Sat 2/285:38 am
MEM
-
DSM
1 stop5h 06m
American Airlines
Deal found 1/27$247
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:35 am
DSM
-
MOB
1 stop6h 20m
Delta
Wed 4/86:15 am
MOB
-
DSM
1 stop4h 33m
Delta
Deal found 1/26$269
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:15 pm
DSM
-
BTR
1 stop4h 46m
Delta
Tue 3/36:18 am
BTR
-
DSM
1 stop5h 01m
Delta
Deal found 1/27$269
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/235:15 pm
DSM
-
MEM
1 stop6h 08m
Delta
Mon 3/26:00 am
MEM
-
DSM
1 stop4h 17m
Delta
Deal found 1/26$277
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:32 am
DSM
-
BTR
2 stops11h 14m
American Airlines
Tue 3/34:27 pm
BTR
-
DSM
2 stops7h 13m
American Airlines
Deal found 1/27$279
This Southwest deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/234:40 pm
DSM
-
MEM
2 stops5h 50m
Southwest
Mon 3/22:35 pm
MEM
-
DSM
2 stops7h 40m
Southwest
Deal found 1/26$287
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:10 am
DSM
-
MEM
2 stops11h 00m
Southwest
Sat 2/2810:40 am
MEM
-
DSM
2 stops8h 35m
Southwest
Deal found 1/27$299
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/104:25 pm
DSM
-
MEM
1 stop4h 01m
Delta
Mon 4/135:59 pm
MEM
-
DSM
1 stop4h 35m
Delta
Deal found 1/27$302
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:30 pm
DSM
-
MOB
1 stop4h 27m
Delta
Sat 10/245:55 am
MOB
-
DSM
1 stop4h 23m
Delta
Deal found 1/26$304
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/157:52 am
DSM
-
GPT
1 stop5h 28m
United Airlines
Sat 2/214:55 pm
GPT
-
DSM
1 stop5h 20m
United Airlines
Deal found 1/25$304
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2112:28 pm
DSM
-
MOB
2 stops11h 23m
American Airlines
Wed 3/255:15 am
MOB
-
DSM
1 stop7h 52m
American Airlines
Deal found 1/26$331
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:30 pm
DSM
-
MOB
1 stop4h 30m
Delta
Tue 4/216:00 am
MOB
-
DSM
1 stop5h 05m
Delta
Deal found 1/26$334

Find flight deals from Des Moines to Mississippi

Keep the following information in mind while searching for Des Moines to Mississippi flight deals. Data was last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$247
(American Airlines)

One-way from

$164
(United Airlines)
Provider with most accurate pricing for Des Moines-Jackson-Evers Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Jackson-Evers Intl flights.
Search Deals
From Des Moines to Mississippi
Search Deals
One-way flight from Des Moines to Mississippi
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Des Moines to Mississippi that are best for you.

Fly from

Des Moines

Fly to

Mississippi

Route

Depart

Return

Price

Des MoinesBaton Rouge

DSM - BTR

DSMBTR

Des Moines

Tue 2/24

7:15 am-12:51 pm

1 stop5h 36m

Baton Rouge Ryan

Tue 3/3

1:30 pm-9:19 pm

1 stop7h 49m

$269

Des MoinesBaton Rouge

DSM - BTR

DSMBTR

Des Moines

Tue 2/24

10:57 am-10:01 pm

2 stops11h 04m

Baton Rouge Ryan

Tue 3/3

6:18 am-11:19 am

1 stop5h 01m

$274

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 2/23

5:15 pm-11:23 pm

1 stop6h 08m

Memphis

Mon 3/2

6:00 am-10:17 am

1 stop4h 17m

$277

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 2/23

4:40 pm-10:30 pm

2 stops5h 50m

Memphis

Mon 3/2

2:35 pm-10:15 pm

2 stops7h 40m

$287

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Tue 2/24

6:10 am-5:10 pm

2 stops11h 00m

Memphis

Sat 2/28

10:40 am-7:15 pm

2 stops8h 35m

$299

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 4/10

4:25 pm-8:26 pm

1 stop4h 01m

Memphis

Mon 4/13

5:59 pm-10:34 pm

1 stop4h 35m

$302

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sun 2/15

7:52 am-1:20 pm

1 stop5h 28m

Gulfport Biloxi Regional

Sat 2/21

4:55 pm-10:15 pm

1 stop5h 20m

$304

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Wed 4/1

4:25 pm-11:28 pm

2 stops7h 03m

Mobile

Wed 4/8

6:15 am-10:48 am

1 stop4h 33m

$309

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Fri 4/17

6:30 pm-11:00 pm

1 stop4h 30m

Mobile

Tue 4/21

6:00 am-11:05 am

1 stop5h 05m

$334

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Tue 5/5

3:20 pm-9:59 pm

1 stop6h 39m

Memphis

Fri 5/8

7:25 am-2:24 pm

1 stop6h 59m

$349

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 39 results
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Best time to book a flight from Des Moines to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mississippi

What is the cheapest month to book a flight from Des Moines to Mississippi?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $248). Flying from Des Moines to Mississippi in November is currently the most expensive (average of $371). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated January 28, 2026.
Peruse reviews from past customers who have flown with American Airlines from Des Moines to Mississippi to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,201 reviews

Boarding

7.5

Food

6.4

Overall

7.2

Comfort

7.2

Crew

8.0

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,201 reviews
American Airlines
7.2
Good
11,201 reviews

Boarding

7.5

Food

6.4

Overall

7.2

Comfort

7.2

Crew

8.0

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mississippi?

    If you book a flight to Mississippi from Des Moines, you will be flying from Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • How long is the flight from Des Moines to Mississippi?

    A quick flight from Des Moines to Mississippi can take about 5h 36m. American Airlines provides one of the quickest options available for as low as $269. Des Moines and Mississippi are separated by a distance of 773 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Des Moines to Mississippi?

    When deciding which route to take from Des Moines to Mississippi consider Des Moines - Mobile, Des Moines - Memphis or Des Moines - Baton Rouge Ryan as they are the most popular.

  • Can I find deals for flights from Des Moines to Mississippi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mississippi.

  • Can I find deals for business class flights from Des Moines to Mississippi?

    Yes. Cheapflights offers flight deals from Des Moines to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mississippi?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $248). Flying from Des Moines to Mississippi in November is currently the most expensive (average of $371). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Des Moines to Mississippi

Discover the top airline that operate flights from Des Moines to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$308FlexibilityNo cancel feeOn-time71%

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