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$99+ Cheap flights from Des Moines (DSM) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
Aug 18 — Aug 251
Mon 8/18
Mon 8/25
1 adult, Economy
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Cheap flight deals from Des Moines to Mississippi

Keep the following information in mind while searching for Des Moines to Mississippi flight deals. Data was last updated August 13, 2025.

Round-trip from

$197
(American Airlines)

One-way from

$99
(American Airlines)
From Des Moines to Mississippi
Search Deals
One-way flight from Des Moines to Mississippi
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Find flight deals from Des Moines to Mississippi

Cheapest flights from Des Moines to Mississippi
Explore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 13, 2025.

This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/84:09 pmDSM - MEM
1 stop4h 38mAmerican Airlines
Thu 9/117:03 pmMEM - DSM
1 stop5h 12mAmerican Airlines
Deal found 8/11$197
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/273:46 pmDSM - MEM
2 stops7h 13mAmerican Airlines
Sat 10/46:08 pmMEM - DSM
1 stop4h 58mAmerican Airlines
Deal found 8/13$202
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/86:00 amDSM - MEM
2 stops11h 25mSouthwest
Thu 9/113:35 pmMEM - DSM
2 stops7h 15mSouthwest
Deal found 8/11$213
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/246:07 pmDSM - MEM
1 stop5h 52mAmerican Airlines
Tue 10/2810:09 amMEM - DSM
1 stop6h 53mAmerican Airlines
Deal found 8/11$241
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/162:05 pmDSM - MOB
1 stop4h 07mDelta
Sat 9/209:10 amMOB - DSM
1 stop7h 12mDelta
Deal found 8/12$249
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/205:38 pmDSM - GPT
1 stop5h 04mAmerican Airlines
Sat 9/276:29 pmGPT - DSM
1 stop4h 44mAmerican Airlines
Deal found 8/13$249
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/278:17 amDSM - GPT
1 stop8h 00mAmerican Airlines
Mon 9/226:29 pmGPT - DSM
1 stop4h 44mAmerican Airlines
Deal found 8/13$254
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/276:15 amDSM - GPT
1 stop7h 12mUnited Airlines
Sun 8/317:05 amGPT - DSM
2 stops9h 08mUnited Airlines
Deal found 8/11$264
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/165:04 amDSM - JAN
1 stop7h 36mAmerican Airlines
Mon 10/206:15 pmJAN - DSM
1 stop4h 41mAmerican Airlines
Deal found 8/12$272
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/65:00 amDSM - MOB
1 stop4h 58mAmerican Airlines
Fri 11/1410:28 amMOB - DSM
1 stop6h 23mAmerican Airlines
Deal found 8/11$279
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/235:44 amDSM - MOB
1 stop5h 43mDelta
Tue 8/266:00 amMOB - DSM
1 stop4h 38mDelta
Deal found 8/10$284
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/245:12 amDSM - MOB
1 stop6h 37mAmerican Airlines
Sun 8/315:10 amMOB - DSM
2 stops10h 08mAmerican Airlines
Deal found 8/11$289

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 13, 2025.
Use the filters below to find and compare flights from Des Moines to Mississippi that are best for you.

Fly from

Des Moines

Fly to

Mississippi

Route

Depart

Return

Price

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sat 9/27

4:20 pm-9:03 pm

1 stop4h 43m

Memphis

Sat 10/4

6:08 pm-11:06 pm

1 stop4h 58m

$197

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 9/8

4:09 pm-8:47 pm

1 stop4h 38m

Memphis

Thu 9/11

7:03 pm-12:15 am

1 stop5h 12m

$197

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 9/8

6:00 am-5:25 pm

2 stops11h 25m

Memphis

Thu 9/11

3:35 pm-10:50 pm

2 stops7h 15m

$213

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 10/24

6:07 pm-11:59 pm

1 stop5h 52m

Memphis

Tue 10/28

10:09 am-5:02 pm

1 stop6h 53m

$241

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Sat 11/8

10:50 am-3:39 pm

1 stop4h 49m

Mobile

Tue 11/11

12:10 pm-5:39 pm

1 stop5h 29m

$249

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Tue 9/16

2:05 pm-6:12 pm

1 stop4h 07m

Mobile

Sat 9/20

9:10 am-4:22 pm

1 stop7h 12m

$249

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Tue 9/16

5:38 pm-11:11 pm

1 stop5h 33m

Mobile

Sat 9/20

5:22 pm-11:06 pm

1 stop5h 44m

$249

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sat 9/20

5:38 pm-10:42 pm

1 stop5h 04m

Gulfport Biloxi Regional

Sat 9/27

6:29 pm-11:13 pm

1 stop4h 44m

$249

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Wed 8/27

8:17 am-4:17 pm

1 stop8h 00m

Gulfport Biloxi Regional

Mon 9/22

6:29 pm-11:13 pm

1 stop4h 44m

$254

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Sat 11/8

1:24 pm-11:59 pm

2 stops10h 35m

Mobile

Tue 11/11

6:33 am-3:32 pm

2 stops8h 59m

$259

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Showing 1-10 of 29 results
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Best time to book a flight from Des Moines to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mississippi

What is the cheapest month to book a flight from Des Moines to Mississippi?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $371). Flying from Des Moines to Mississippi in March is currently the most expensive (average of $448). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated August 13, 2025.
Peruse reviews from past customers who have flown with American Airlines from Des Moines to Mississippi to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Overall

7.2

Comfort

7.2

Entertainment

6.9

Boarding

7.5

Crew

8.0

Food

6.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Overall

7.2

Comfort

7.2

Entertainment

6.9

Boarding

7.5

Crew

8.0

Food

6.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mississippi?

    If you book a flight to Mississippi from Des Moines, you will be flying from Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • What are the most popular routes from Des Moines to Mississippi?

    When deciding which route to take from Des Moines to Mississippi consider Des Moines - Mobile, Des Moines - Memphis or Des Moines - Gulfport Biloxi Regional as they are the most popular.

  • Can I find deals for flights from Des Moines to Mississippi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mississippi.

  • Can I find deals for business class flights from Des Moines to Mississippi?

    Yes. Cheapflights offers flight deals from Des Moines to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mississippi?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $371). Flying from Des Moines to Mississippi in March is currently the most expensive (average of $448). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Omaha to Miami flights
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Omaha to Atlanta flights
Moline to Orlando flights
Des Moines to Baltimore flights
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Des Moines to Miami flights
Des Moines to Seattle flights

Top airline flying from Des Moines to Mississippi

Discover the top airline that operate flights from Des Moines to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$352FlexibilityNo cancel feeOn-time71%

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