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$193+ Cheap flights from Des Moines (DSM) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/9. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
Nov 22 — Nov 291
Sat 11/22
Sat 11/29
1 adult, Economy
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Find flight deals from Des Moines to Mississippi

Cheapest flights from Des Moines to Mississippi
Explore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/98:20 amDSM - MEM
1 stop8h 55mSouthwest
Tue 12/163:00 pmMEM - DSM
2 stops6h 35mSouthwest
Deal found 10/22$196
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/96:50 amDSM - MEM
1 stop4h 35mDelta
Tue 12/165:55 amMEM - DSM
1 stop4h 26mDelta
Deal found 10/22$203
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/63:00 pmDSM - JAN
1 stop4h 30mDelta
Sat 12/138:00 amJAN - DSM
1 stop6h 12mDelta
Deal found 10/22$239
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/63:38 pmDSM - MOB
1 stop7h 24mAmerican Airlines
Sat 12/135:10 amMOB - DSM
1 stop8h 09mAmerican Airlines
Deal found 10/22$249
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/63:00 pmDSM - BTR
1 stop6h 12mDelta
Sat 12/137:39 amBTR - DSM
1 stop6h 33mDelta
Deal found 10/22$249
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/245:35 amDSM - GPT
1 stop4h 14mDelta
Wed 12/36:00 amGPT - DSM
1 stop4h 38mDelta
Deal found 10/21$249
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/65:26 pmDSM - MOB
1 stop5h 24mAmerican Airlines
Fri 11/145:08 amMOB - DSM
1 stop5h 32mAmerican Airlines
Deal found 10/23$254
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/63:30 pmDSM - MEM
1 stop7h 09mDelta
Sat 12/136:00 amMEM - DSM
1 stop4h 38mDelta
Deal found 10/22$264
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:40 pmDSM - MEM
1 stop5h 22mAmerican Airlines
Mon 11/174:59 pmMEM - DSM
1 stop6h 00mAmerican Airlines
Deal found 10/22$265
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/74:59 pmDSM - MEM
1 stop5h 40mDelta
Sun 12/142:12 pmMEM - DSM
1 stop6h 34mDelta
Deal found 10/23$281
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/245:35 amDSM - GPT
1 stop4h 14mDelta
Tue 12/26:01 pmGPT - DSM
1 stop4h 33mDelta
Deal found 10/21$284
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:05 amDSM - GPT
1 stop5h 12mUnited Airlines
Mon 11/107:00 amGPT - DSM
2 stops9h 12mUnited Airlines
Deal found 10/22$291

Cheap flight deals from Des Moines to Mississippi

Keep the following information in mind while searching for Des Moines to Mississippi flight deals. Data was last updated October 23, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$196
(Southwest)

One-way from

$193
(Delta)
Provider with most accurate pricing for Des Moines-Jackson-Evers Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Jackson-Evers Intl flights.
Search Deals
From Des Moines to Mississippi
Search Deals
One-way flight from Des Moines to Mississippi
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
Use the filters below to find and compare flights from Des Moines to Mississippi that are best for you.

Fly from

Des Moines

Fly to

Mississippi

Route

Depart

Return

Price

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Tue 12/9

6:15 am-2:50 pm

2 stops8h 35m

Memphis

Tue 12/16

3:00 pm-9:35 pm

2 stops6h 35m

$196

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Tue 12/9

6:50 am-11:25 am

1 stop4h 35m

Memphis

Tue 12/16

5:55 am-10:21 am

1 stop4h 26m

$203

Des MoinesJackson

DSM - JAN

DSMJAN

Des Moines

Sat 12/6

3:00 pm-7:30 pm

1 stop4h 30m

Jackson-Evers Intl

Sat 12/13

8:00 am-2:12 pm

1 stop6h 12m

$239

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 1/16

5:01 pm-11:05 pm

1 stop6h 04m

Memphis

Wed 1/21

10:27 am-3:45 pm

1 stop5h 18m

$242

Des MoinesBaton Rouge

DSM - BTR

DSMBTR

Des Moines

Thu 1/22

5:51 pm-10:56 pm

1 stop5h 05m

Baton Rouge Ryan

Thu 1/29

10:41 am-3:14 pm

1 stop4h 33m

$249

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Tue 3/3

5:15 pm-10:59 pm

1 stop5h 44m

Mobile

Sat 3/7

5:55 am-10:23 am

1 stop4h 28m

$249

Des MoinesBaton Rouge

DSM - BTR

DSMBTR

Des Moines

Sat 12/6

3:00 pm-9:12 pm

1 stop6h 12m

Baton Rouge Ryan

Sat 12/13

7:39 am-2:12 pm

1 stop6h 33m

$249

Des MoinesBaton Rouge

DSM - BTR

DSMBTR

Des Moines

Thu 1/22

8:00 am-5:53 pm

2 stops9h 53m

Baton Rouge Ryan

Thu 1/29

5:15 pm-10:30 pm

1 stop5h 15m

$254

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Wed 4/1

6:20 am-6:22 pm

2 stops12h 02m

Mobile

Wed 4/8

5:55 am-10:23 am

1 stop4h 28m

$254

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Mon 11/24

5:35 am-9:49 am

1 stop4h 14m

Gulfport Biloxi Regional

Wed 12/3

6:00 am-2:19 pm

2 stops8h 19m

$254

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/22

Showing 1-10 of 56 results
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Best time to book a flight from Des Moines to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mississippi

What is the cheapest month to book a flight from Des Moines to Mississippi?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $248). Flying from Des Moines to Mississippi in December is currently the most expensive (average of $443). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated October 23, 2025.
Peruse reviews from past customers who have flown with American Airlines from Des Moines to Mississippi to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,033 reviews

Overall

7.2

Crew

8.0

Comfort

7.2

Boarding

7.5

Food

6.4

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
11,033 reviews
American Airlines
7.2
Good
11,033 reviews

Overall

7.2

Crew

8.0

Comfort

7.2

Boarding

7.5

Food

6.4

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mississippi?

    If you book a flight to Mississippi from Des Moines, you will be flying from Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • How long is the flight from Des Moines to Mississippi?

    A quick flight from Des Moines to Mississippi can take about 4h 35m. Southwest provides one of the quickest options available for as low as $203. Des Moines and Mississippi are separated by a distance of 491 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Des Moines to Mississippi one-way?

    The cheapest airlines for a one-way flight from Des Moines to Mississippi are Delta ($193), American Airlines ($198), and United Airlines ($239).

  • What are the most popular routes from Des Moines to Mississippi?

    When deciding which route to take from Des Moines to Mississippi consider Des Moines - Mobile, Des Moines - Gulfport Biloxi Regional or Des Moines - Memphis as they are the most popular.

  • Can I find deals for flights from Des Moines to Mississippi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mississippi.

  • Can I find deals for business class flights from Des Moines to Mississippi?

    Yes. Cheapflights offers flight deals from Des Moines to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mississippi?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $248). Flying from Des Moines to Mississippi in December is currently the most expensive (average of $443). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Des Moines to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Cedar Rapids to John F Kennedy Intl flights
Omaha to Boston flights
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Top airline flying from Des Moines to Mississippi

Discover the top airline that operate flights from Des Moines to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$358FlexibilityNo cancel feeOn-time71%

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