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Mesa

$28+ Cheap flights from Missouri to Mesa, AZ

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/20. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PHX
Dec 24 — Dec 311
Wed 12/24
Wed 12/31
1 adult, Economy
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Find flight deals from Missouri to Mesa

Cheapest flights from Missouri to Mesa
Explore the most affordable flight options available from Missouri to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 24, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1811:53 amMCI - PHX
Nonstop3h 02mFrontier
Thu 12/257:20 amPHX - MCI
Nonstop2h 38mFrontier
Deal found 11/22$128
This Super.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1110:52 amMCI - PHX
Nonstop3h 02mFrontier
Mon 12/1512:16 pmPHX - MCI
1 stop6h 34mFrontier
Deal found 11/23$147
This Frontier deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/711:58 amMCI - PHX
Nonstop3h 02mFrontier
Mon 12/89:16 amPHX - MCI
1 stop9h 34mFrontier
Deal found 11/21$148
This Super.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/214:32 pmMCI - PHX
Nonstop3h 02mFrontier
Thu 12/257:20 amPHX - MCI
Nonstop2h 38mFrontier
Deal found 11/23$150
This Southwest deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/171:50 pmMCI - PHX
Nonstop2h 55mSouthwest
Wed 12/246:30 pmPHX - MCI
Nonstop2h 30mSouthwest
Deal found 11/23$154
This Super.com deal was found by Cheapflights users on 11/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1512:07 pmSTL - PHX
Nonstop3h 31mFrontier
Mon 12/224:10 pmPHX - STL
Nonstop2h 57mFrontier
Deal found 11/22$157
This Super.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1212:07 pmSTL - PHX
Nonstop3h 31mFrontier
Mon 12/157:25 amPHX - STL
Nonstop2h 57mFrontier
Deal found 11/23$162
This FlightHub deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:45 pmMCI - PHX
1 stop4h 44mFrontier
Mon 12/2910:31 pmPHX - MCI
1 stop20h 19mFrontier
Deal found 11/23$163
This Expedia deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:45 pmMCI - PHX
1 stop4h 44mFrontier
Sun 12/2810:31 pmPHX - MCI
1 stop20h 19mFrontier
Deal found 11/23$164
This FlightHub deal was found by Cheapflights users on 11/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/812:07 pmSTL - PHX
Nonstop3h 31mFrontier
Mon 12/157:25 amPHX - STL
Nonstop2h 57mFrontier
Deal found 11/22$164
This Kiwi.com deal was found by Cheapflights users on 11/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/187:00 amMCI - PHX
1 stop13h 16mMultiple Airlines
Thu 12/257:20 amPHX - MCI
Nonstop2h 38mMultiple Airlines
Deal found 11/22$165
This Super.com deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:09 pmMCI - PHX
1 stop5h 35mFrontier
Sun 12/77:25 amPHX - MCI
Nonstop2h 38mFrontier
Deal found 11/21$166

Cheap flight deals from Missouri to Mesa

Keep the following information in mind while searching for Missouri to Mesa flight deals. Data was last updated November 24, 2025.

Round-trip from

$128
(Kiwi.com)

One-way from

$28
(FlightHub)

Popular in

March

Cheapest in

October

Average price

$318
From Missouri to Mesa
Search Deals
One-way flight from Missouri to Mesa
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 24, 2025.
Use the filters below to find and compare flights from Missouri to Mesa that are best for you.

Fly from

Missouri

Fly to

Mesa

Route

Depart

Return

Price

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Sat 2/21

11:15 am-7:18 pm

1 stop9h 03m

Phoenix Sky Harbor Intl

Sat 2/28

1:45 pm-9:33 pm

1 stop6h 48m

$248

SpringfieldPhoenix

SGF - PHX

SGFPHX

Springfield-Branson

Wed 1/7

5:00 pm-11:40 pm

1 stop7h 40m

Phoenix Sky Harbor Intl

Wed 1/14

11:55 am-9:46 pm

1 stop8h 51m

$251

St. LouisPhoenix

STL - PHX

STLPHX

Lambert-St Louis

Thu 1/8

2:45 pm-7:45 pm

1 stop6h 00m

Phoenix Sky Harbor Intl

Mon 1/12

2:42 pm-8:58 pm

1 stop5h 16m

$251

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Sat 1/10

8:09 am-2:16 pm

1 stop7h 07m

Phoenix Sky Harbor Intl

Sat 1/17

6:45 am-5:19 pm

2 stops9h 34m

$254

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Wed 1/7

8:09 am-6:06 pm

2 stops10h 57m

Phoenix Sky Harbor Intl

Sat 1/10

12:56 pm-8:33 pm

1 stop6h 37m

$254

SpringfieldPhoenix

SGF - PHX

SGFPHX

Springfield-Branson

Fri 2/6

5:00 pm-11:57 pm

1 stop7h 57m

Phoenix Sky Harbor Intl

Fri 2/13

12:59 am-9:53 am

1 stop7h 54m

$255

Kansas CityPhoenix

MCI - PHX

MCIPHX

Kansas City

Fri 12/12

5:30 pm-12:04 am

1 stop7h 34m

Phoenix Sky Harbor Intl

Tue 12/16

7:15 am-3:00 pm

1 stop6h 45m

$263

Kansas CityPhoenix

MCI - PHX

MCIPHX

Kansas City

Thu 12/18

6:22 pm-12:46 am

1 stop7h 24m

Phoenix Sky Harbor Intl

Wed 12/24

1:08 am-9:44 am

1 stop7h 36m

$282

SpringfieldPhoenix

SGF - PHX

SGFPHX

Springfield-Branson

Sun 12/21

6:15 am-12:09 pm

1 stop6h 54m

Phoenix Sky Harbor Intl

Sat 12/27

12:45 am-10:49 am

1 stop9h 04m

$291

St. LouisPhoenix

STL - PHX

STLPHX

Lambert-St Louis

Sat 2/21

8:45 pm-11:15 pm

Nonstop3h 30m

Phoenix Sky Harbor Intl

Sat 2/28

6:00 am-9:50 am

Nonstop2h 50m

$297

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/23

Showing 1-10 of 57 results
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Best time to book a flight from Missouri to Mesa

Have a flexible travel schedule? Discover the best time to fly to Mesa from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Mesa

What is the cheapest month to book a flight from Missouri to Mesa?

Currently, December is the cheapest month in which you can book a flight from Missouri to Mesa (average of $100). Flying from Missouri to Mesa in March is currently the most expensive (average of $188). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to MS9?

Find hourly flight availability from Missouri to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 24, 2025.

It’s typically best to fly out from Missouri to Mesa in the evening. Doing so could potentially save you 44% on the flight price compared to flying at noon, which is usually more expensive.

What is the cheapest day to fly from Missouri to Mesa?

Use this chart to determine the cheapest time to fly round-trip from Missouri to Mesa. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to Mesa flight should consider departing on Friday evenings when fares are most often at their lowest. Saturday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Missouri to Mesa

Explore weekly flight availability from Missouri to Mesa. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated November 24, 2025.

The most flights from USMO to MS9 are scheduled on a Saturday (13 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (2 on average).

Related info for your journey

Find useful and relevant information for your journey from Missouri to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Mesa?

    Departing from Missouri to Mesa will take you 7h 40m. Airlines will cover a distance of 1079 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to Mesa one-way?

    One-way options have recently been found by users for as low as $56 on Frontier. Other airlines that offer cheap prices include American Airlines from $70 and Southwest from $70 one-way.

  • What are the most popular routes from Missouri to Mesa?

    The most popular route from Missouri to Mesa is Kansas City - Phoenix Sky Harbor Intl. You may also consider Lambert-St Louis - Phoenix Sky Harbor Intl or Springfield-Branson - Phoenix Sky Harbor Intl.

  • What are the most reliable airlines from Missouri to Mesa?

    Consider SkyWest Airlines (100%), American Airlines (82%) or Frontier (80%) when booking your flight. These represent the most reliable airlines when flying from Missouri to Mesa.

  • What are the cheapest flights from Missouri to Mesa?

    On average you can expect to pay $409 for a flight from Missouri to Mesa. The cheapest flight overall is $69 while the most popular route, (Kansas City - Phoenix Sky Harbor Intl) is currently priced at $137.

  • Can I find deals for flights from Missouri to Mesa that include hotel bookings?

    Yes. In addition to deals on Missouri to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Mesa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Mesa.

  • Can I find deals for business class flights from Missouri to Mesa?

    Yes. Cheapflights offers flight deals from Missouri to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Mesa?

    Currently, December is the cheapest month in which you can book a flight from Missouri to Mesa (average of $100). Flying from Missouri to Mesa in March is currently the most expensive (average of $188). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Missouri to Mesa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from Missouri to Mesa

Discover the top 7 airlines that operate flights from Missouri to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$94Average$205FlexibilityNo cancel feeOn-time62%
Spirit AirlinesCheapest$139Average$232FlexibilityNo cancel feeOn-time65%
Allegiant AirCheapest$140Average$236FlexibilityNo cancel feeOn-time88%
SouthwestCheapest$216Average$397FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$223Average$438FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$224Average$428FlexibilityNo cancel feeOn-time71%
DeltaCheapest$234Average$342FlexibilityNo cancel feeOn-timeN/A

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