$78+ Cheap flights from Mesa, AZ to St. Louis (STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — STL
May 20 — May 271
Round-trip
1 adult, Economy
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Find cheap flights from Mesa to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Lambert-St Louis are usually found in January or October, booked 25 days in advance, depart on a Friday or Tuesday and return on a Wednesday
Cheap flight deals from Mesa to St. Louis
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Best
Last-minute
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Cheapest flights from Mesa to St. LouisExplore the most affordable flight options available from Mesa to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 20, 2026.
Explore the most affordable flight options available from Mesa to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 20, 2026.
This CheapOair deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/224:17 pm
PHX
- STL
1 stop25h 06m
Frontier
Tue 5/268:08 pm
STL
- PHX
1 stop21h 15m
Frontier
Deal found 4/16![Frontier logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/2511:30 pm
PHX
- STL
1 stop16h 03m
Frontier
Fri 5/299:06 pm
STL
- PHX
2 stops12h 38m
Frontier
Deal found 4/15![Frontier logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3111:30 pm
PHX
- STL
1 stop7h 25m
Frontier
Fri 6/59:06 pm
STL
- PHX
2 stops12h 38m
Frontier
Deal found 4/15![Frontier logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1612:05 pm
PHX
- STL
2 stops10h 16m
Frontier
Wed 5/206:51 pm
STL
- PHX
1 stop6h 33m
Frontier
Deal found 4/17![Frontier logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:29 pm
PHX
- STL
2 stops22h 25m
Frontier
Mon 5/118:08 pm
STL
- PHX
1 stop5h 21m
Frontier
Deal found 4/17![Frontier logo]()
$285
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/128:55 am
PHX
- STL
Nonstop2h 55m
Southwest
Tue 5/198:45 pm
STL
- PHX
Nonstop3h 25m
Southwest
Deal found 4/20![Southwest logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/259:05 am
PHX
- STL
2 stops32h 18m
Frontier
Tue 6/98:08 pm
STL
- PHX
1 stop5h 21m
Frontier
Deal found 4/19![Frontier logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/612:05 pm
PHX
- STL
2 stops21h 36m
Frontier
Sun 5/108:08 pm
STL
- PHX
1 stop5h 21m
Frontier
Deal found 4/15![Frontier logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:29 pm
PHX
- STL
2 stops18h 26m
Frontier
Sun 5/108:08 pm
STL
- PHX
1 stop5h 21m
Frontier
Deal found 4/15![Frontier logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:51 pm
PHX
- STL
2 stops33h 59m
Frontier
Tue 5/56:51 pm
STL
- PHX
1 stop6h 33m
Frontier
Deal found 4/18![Frontier logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:16 am
PHX
- STL
1 stop7h 20m
Frontier
Fri 5/89:18 pm
STL
- PHX
2 stops14h 47m
Frontier
Deal found 4/17![Frontier logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/48:40 am
PHX
- STL
1 stop8h 43m
Frontier
Sun 6/79:06 pm
STL
- PHX
2 stops12h 38m
Frontier
Deal found 4/15![Frontier logo]()
$294
Best flights from Mesa to St. LouisDiscover carefully curated flight deals from Mesa to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 20, 2026.
Discover carefully curated flight deals from Mesa to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 20, 2026.
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:20 pm
PHX
- STL
Nonstop2h 55m
Southwest
Thu 5/289:40 pm
STL
- PHX
Nonstop3h 25m
Southwest
Deal found 4/19![Southwest logo]()
$347
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:00 am
PHX
- STL
Nonstop2h 50m
Southwest
Wed 6/246:05 pm
STL
- PHX
1 stop6h 15m
Southwest
Deal found 4/15![Southwest logo]()
$351
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:40 pm
PHX
- STL
Nonstop2h 55m
Southwest
Wed 9/22:45 pm
STL
- PHX
1 stop6h 15m
Southwest
Deal found 4/15![Southwest logo]()
$351
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:40 pm
PHX
- STL
Nonstop2h 55m
Southwest
Tue 9/158:45 pm
STL
- PHX
Nonstop3h 10m
Southwest
Deal found 4/18![Southwest logo]()
$375
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3011:55 pm
PHX
- STL
1 stop7h 35m
Southwest
Sat 6/208:45 pm
STL
- PHX
Nonstop3h 10m
Southwest
Deal found 4/15![Southwest logo]()
$385
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:40 pm
PHX
- STL
Nonstop2h 50m
Southwest
Thu 5/218:35 am
STL
- PHX
1 stop5h 45m
Southwest
Deal found 4/16![Southwest logo]()
$410
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:55 pm
PHX
- STL
Nonstop2h 55m
Southwest
Sun 9/279:15 pm
STL
- PHX
Nonstop3h 10m
Southwest
Deal found 4/19![Southwest logo]()
$415
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/108:55 pm
PHX
- STL
Nonstop2h 55m
Southwest
Sun 7/129:45 pm
STL
- PHX
Nonstop3h 10m
Southwest
Deal found 4/19![Southwest logo]()
$415
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:40 pm
PHX
- STL
1 stop5h 10m
Southwest
Sun 5/179:55 pm
STL
- PHX
Nonstop3h 25m
Southwest
Deal found 4/15![Southwest logo]()
$425
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/145:00 am
PHX
- STL
Nonstop2h 50m
Southwest
Sun 6/215:40 am
STL
- PHX
1 stop5h 05m
Southwest
Deal found 4/15![Southwest logo]()
$425
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/164:55 pm
PHX
- STL
Nonstop2h 50m
Southwest
Sat 5/235:20 pm
STL
- PHX
1 stop6h 05m
Southwest
Deal found 4/19![Southwest logo]()
$425
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/102:10 pm
PHX
- STL
Nonstop2h 55m
Southwest
Tue 5/128:35 am
STL
- PHX
1 stop5h 05m
Southwest
Deal found 4/15![Southwest logo]()
$433
Last-minute flights from Mesa to St. LouisDiscover last-minute flight deals from Mesa to St. Louis. Data last updated April 20, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to St. Louis. Data last updated April 20, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:51 pm
PHX
- STL
2 stops33h 59m
Frontier
Tue 5/56:51 pm
STL
- PHX
1 stop6h 33m
Frontier
Deal found 4/18![Frontier logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:16 am
PHX
- STL
1 stop7h 20m
Frontier
Sun 5/103:33 pm
STL
- PHX
2 stops19h 14m
Frontier
Deal found 4/17![Frontier logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:16 am
PHX
- STL
1 stop7h 20m
Frontier
Fri 5/89:18 pm
STL
- PHX
2 stops14h 47m
Frontier
Deal found 4/17![Frontier logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:29 pm
PHX
- STL
2 stops22h 25m
Frontier
Mon 5/118:08 pm
STL
- PHX
1 stop5h 21m
Frontier
Deal found 4/17![Frontier logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/612:05 pm
PHX
- STL
2 stops21h 36m
Frontier
Sun 5/108:08 pm
STL
- PHX
1 stop5h 21m
Frontier
Deal found 4/15![Frontier logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:29 pm
PHX
- STL
2 stops18h 26m
Frontier
Sun 5/108:08 pm
STL
- PHX
1 stop5h 21m
Frontier
Deal found 4/15![Frontier logo]()
$291
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/128:55 am
PHX
- STL
Nonstop2h 55m
Southwest
Tue 5/198:45 pm
STL
- PHX
Nonstop3h 25m
Southwest
Deal found 4/20![Southwest logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1612:05 pm
PHX
- STL
2 stops10h 16m
Frontier
Wed 5/206:51 pm
STL
- PHX
1 stop6h 33m
Frontier
Deal found 4/17![Frontier logo]()
$284
This CheapOair deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/224:17 pm
PHX
- STL
1 stop25h 06m
Frontier
Tue 5/268:08 pm
STL
- PHX
1 stop21h 15m
Frontier
Deal found 4/16![Frontier logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/2511:30 pm
PHX
- STL
1 stop16h 03m
Frontier
Fri 5/299:06 pm
STL
- PHX
2 stops12h 38m
Frontier
Deal found 4/15![Frontier logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/259:05 am
PHX
- STL
2 stops32h 18m
Frontier
Tue 6/98:08 pm
STL
- PHX
1 stop5h 21m
Frontier
Deal found 4/19![Frontier logo]()
$287
One-way flights from Mesa to St. LouisSearch for one-way flight options from Mesa to St. Louis. Find affordable one-way fares based on user searches. Data last updated April 20, 2026.
Search for one-way flight options from Mesa to St. Louis. Find affordable one-way fares based on user searches. Data last updated April 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:51 pm
PHX
- STL
1 stop22h 32m
Frontier
Deal found 4/16![Frontier logo]()
$78
This Super.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:40 am
PHX
- STL
1 stop8h 26m
Frontier
Deal found 4/20![Frontier logo]()
$79
This CheapOair deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:40 am
PHX
- STL
1 stop8h 26m
Frontier
Deal found 4/20![Frontier logo]()
$80
This Super.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1610:27 pm
PHX
- STL
1 stop11h 14m
Frontier
Deal found 4/16![Frontier logo]()
$84
This Super.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:15 am
PHX
- STL
1 stop12h 08m
Frontier
Deal found 4/17![Frontier logo]()
$85
This Frontier deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:40 am
PHX
- STL
1 stop10h 43m
Frontier
Deal found 4/16![Frontier logo]()
$86
This Flightnetwork deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/214:17 pm
PHX
- STL
1 stop25h 06m
Frontier
Deal found 4/20![Frontier logo]()
$87
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1610:27 pm
PHX
- STL
2 stops18h 56m
Frontier
Deal found 4/16![Frontier logo]()
$90
This CheapOair deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2310:27 pm
PHX
- STL
1 stop19h 44m
Frontier
Deal found 4/20![Frontier logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:15 am
PHX
- STL
1 stop12h 08m
Frontier
Deal found 4/16![Frontier logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:40 am
PHX
- STL
2 stops33h 43m
Frontier
Deal found 4/17![Frontier logo]()
$96
Find flight deals from Mesa to St. Louis
Keep the following information in mind while searching for Mesa to St. Louis flight deals. Data was last updated April 20, 2026.
Round-trip from | $281 (Frontier) |
|---|---|
One-way from | $78 (Kiwi.com) |
Popular in | April |
Cheapest in | January |
Average price | $468 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 20, 2026.
Use the filters below to find and compare flights from Mesa to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Tue 5/26
6:20 pm-11:15 pm
Nonstop2h 55m
Lambert-St Louis
Thu 5/28
9:40 pm-11:05 pm
Nonstop3h 25m
$347
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Wed 6/17
5:00 am-9:50 am
Nonstop2h 50m
Lambert-St Louis
Wed 6/24
6:05 pm-10:20 pm
1 stop6h 15m
$351
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Wed 8/26
5:40 pm-10:35 pm
Nonstop2h 55m
Lambert-St Louis
Wed 9/2
2:45 pm-7:00 pm
1 stop6h 15m
$351
Quickest round-trip
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Tue 9/8
5:40 pm-10:35 pm
Nonstop2h 55m
Lambert-St Louis
Tue 9/15
8:45 pm-9:55 pm
Nonstop3h 10m
$375
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Sat 5/30
11:55 pm-9:30 am
1 stop7h 35m
Lambert-St Louis
Sat 6/20
8:45 pm-9:55 pm
Nonstop3h 10m
$385
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Thu 5/14
7:40 pm-12:30 am
Nonstop2h 50m
Lambert-St Louis
Thu 5/21
8:35 am-12:20 pm
1 stop5h 45m
$410
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Fri 9/25
6:55 pm-11:50 pm
Nonstop2h 55m
Lambert-St Louis
Sun 9/27
9:15 pm-10:25 pm
Nonstop3h 10m
$415
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Fri 7/10
8:55 pm-1:50 am
Nonstop2h 55m
Lambert-St Louis
Sun 7/12
9:45 pm-10:55 pm
Nonstop3h 10m
$415
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Fri 5/15
4:40 pm-11:50 pm
1 stop5h 10m
Lambert-St Louis
Sun 5/17
9:55 pm-11:20 pm
Nonstop3h 25m
$425
PhoenixSt. Louis
PHX - STL
PHXSTL
Phoenix Sky Harbor Intl
Sun 6/14
5:00 am-9:50 am
Nonstop2h 50m
Lambert-St Louis
Sun 6/21
5:40 am-8:45 am
1 stop5h 05m
$425
Showing 1-10 of 24 resultsSorted by cheapest first
Best time to book a flight from Mesa to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Mesa with our price prediction graph.
PHX-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to St. Louis
MS9-STL
PHX-STL
How far ahead should I book a flight from Mesa to St. Louis?
Use this chart to determine the optimal time to book a round-trip flight from Mesa to St. Louis. Price data was last updated on April 17, 2026.
Booking 25 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mesa to St. Louis. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest time of day to fly from MS9 to STL?
Find hourly flight availability from Mesa to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 20, 2026.
A simple way to save on the total cost of your ticket is to fly from Mesa to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 10% on your trip compared to booking a flight in the evening.
What is the cheapest day to fly from Mesa to St. Louis?
Use this chart to determine the cheapest time to fly round-trip from Mesa to St. Louis. Price data was last updated on April 18, 2026.
Travelers seeking maximum savings on their Mesa to St. Louis flight should consider departing on Monday at noon when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Weekly flight availability from Mesa to St. Louis
Explore weekly flight availability from Mesa to St. Louis. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated April 20, 2026.
The most flights from MS9 to STL are scheduled on a Monday (9 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (4 on average).
How much does it cost to fly round-trip from Mesa to St. Louis?
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated April 20, 2026.
Read reviews from past customers who have flown Southwest,Delta, andAmerican Airlines from Mesa to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Mesa to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Mesa to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mesa to St. Louis by cabin class
Find flights from Mesa to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mesa and St. Louis flights
Browse other Mesa and St. Louis flight options. Last updated on April 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 20, 2026.
Mesa to St. Louis flights
Consider these flights traveling from Mesa to St. Louis.
Top 4 airlines flying from Mesa to St. Louis
Discover the top 4 airlines that operate flights from Mesa to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$99 | Average$208 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$228 | Average$386 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$367 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$257 | Average$395 | FlexibilityNo cancel fee | On-time63% |