What are the cheapest airlines to fly from Mesa to St. Louis one-way?

For one-way options, check prices for Frontier. According to our data, you can fly for as low as $71. Users have also found prices from $153 and $168 on American Airlines and Southwest, respectively.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the cheapest flights from Mesa to St. Louis?

On average you can expect to pay $376 for a flight from Mesa to St. Louis. The cheapest flight overall is $168 while the most popular route, (Phoenix Sky Harbor Intl - Lambert-St Louis) is currently priced at $250.

What are the most popular airlines that fly from Mesa to St. Louis?

Southwest, American Airlines and Frontier are the most popular airlines when flying from Mesa to St. Louis.

What airport do you fly into for flights to St. Louis from Mesa?

For a flight from Mesa to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city. Lambert-St Louis is the only St. Louis airport and it handles 3 inbound flights from Mesa per day. 3 airlines have flights to Lambert-St Louis from Mesa on a regular basis.

Can I find deals for flights from Mesa to St. Louis that include hotel bookings?

Yes. In addition to deals on Mesa to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Mesa to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to St. Louis.

Can I find deals for business class flights from Mesa to St. Louis?

Yes. Cheapflights offers flight deals from Mesa to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

Find Cheap Flights from Mesa to St. Louis

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Mesa to St. Louis with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Mesa to Lambert-St Louis are usually found in January or February, booked 10 days in advance, depart on a Saturday or Friday and return on a Friday

Find flight deals from Mesa to St. Louis

Popular in	June
Cheapest in	January
Average price	$364

Highest demand for flights based on searches. 8% potential increase in price ($34 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in October 2026

Search Deals

Cheapflights Insights

Everything you need to know about your flight from Mesa to St. Louis

What is the cheapest time of day to fly from MS9 to STL?

A simple way to save on the total cost of your ticket is to fly from Mesa to St. Louis in the afternoon. If you’re flexible enough to do this you can expect to save up to 22% on your trip compared to booking a flight at noon.

What is the cheapest day to fly from Mesa to St. Louis?

Travelers seeking maximum savings on their Mesa to St. Louis flight should consider departing on Monday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing St. Louis

Read reviews from past customers who have flown Southwest,American Airlines, andFrontier from Mesa to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

7.9

Good

4,220 reviews

Reviews

1 / 20

10.0

Excellent

Courtney,Sep 2026

DEN - STL

I still think the aircraft should load from the back and window seats first for all passengers. It's so much easier and efficient to board when you do not have to worry about hitting Anyone already seated.

Southwest

7.9

Good

4,220 reviews

Southwest

7.9

Good

4,220 reviews

Reviews

1 / 20

10.0

Excellent

Courtney,Sep 2026

DEN - STL

American Airlines

7.0

Good

12,187 reviews

Southwest

7.9

Good

4,220 reviews

Reviews

1 / 20

10.0

Excellent

Courtney,Sep 2026

DEN - STL

Frontier

5.5

Fair

2,515 reviews

Southwest

7.9

Good

4,220 reviews

Reviews

1 / 20

10.0

Excellent

Courtney,Sep 2026

DEN - STL

Related info for your journey

What airport do you fly into for flights to St. Louis from Mesa?
For a flight from Mesa to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city. Lambert-St Louis is the only St. Louis airport and it handles 3 inbound flights from Mesa per day. 3 airlines have flights to Lambert-St Louis from Mesa on a regular basis.
What are the cheapest airlines to fly from Mesa to St. Louis one-way?
For one-way options, check prices for Frontier. According to our data, you can fly for as low as $71. Users have also found prices from $153 and $168 on American Airlines and Southwest, respectively.
What are the cheapest flights from Mesa to St. Louis?
On average you can expect to pay $376 for a flight from Mesa to St. Louis. The cheapest flight overall is $168 while the most popular route, (Phoenix Sky Harbor Intl - Lambert-St Louis) is currently priced at $250.
Can I find deals for flights from Mesa to St. Louis that include hotel bookings?
Yes. In addition to deals on Mesa to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Mesa to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to St. Louis.
Can I find deals for business class flights from Mesa to St. Louis?
Yes. Cheapflights offers flight deals from Mesa to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Fairview Heights

O'Fallon

Fenton

Swansea

Eureka

Wentzville

Maryland Heights

Chesterfield

Collinsville

Edwardsville

Glencoe

Browse thousands of different options on Cheapflights for your next trip

Alternative routes

Complete your trip

Flights by cabin class

Other flight options

Popular flights

St. Louis flight routes

Top destinations

Alternative routes for Mesa to St. Louis

Sky Harbor Intl to Kansas City flights

Sky Harbor Intl to St. Louis flights

Las Vegas to Kansas City flights

Las Vegas to St. Louis flights

Tucson to St. Louis flights

Tucson to Kansas City flights

Tucson to Springfield flights

Sky Harbor Intl to Springfield flights

Sky Harbor Intl to Joplin flights

Las Vegas to Springfield flights

Sky Harbor Intl to Columbia flights

Las Vegas to Joplin flights

Las Vegas to Columbia flights

Tucson to Joplin flights

Sky Harbor Intl to Branson flights

Las Vegas to Branson flights

Top 3 airlines flying from Mesa to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$101	Average$250	FlexibilityNo cancel fee	On-time62%
American Airlines	Cheapest$230	Average$403	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$297	Average$445	FlexibilityNo cancel fee	On-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

Cheap flights from Mesa, AZ to St. Louis (STL)

Find cheap flights from Mesa to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Mesa to St. Louis

Popular in

Cheapest in

Average price

Cheapflights Insights

What is the cheapest time of day to fly from MS9 to STL?

A simple way to save on the total cost of your ticket is to fly from Mesa to St. Louis in the afternoon. If you’re flexible enough to do this you can expect to save up to 22% on your trip compared to booking a flight at noon.

What is the cheapest day to fly from Mesa to St. Louis?

Travelers seeking maximum savings on their Mesa to St. Louis flight should consider departing on Monday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing St. Louis

Read reviews from past customers who have flown Southwest,American Airlines, andFrontier from Mesa to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

What airport do you fly into for flights to St. Louis from Mesa?

What are the cheapest airlines to fly from Mesa to St. Louis one-way?

What are the cheapest flights from Mesa to St. Louis?

Can I find deals for flights from Mesa to St. Louis that include hotel bookings?

How can I find direct flights from Mesa to St. Louis?

Can I find deals for business class flights from Mesa to St. Louis?

Traveling to a place near St. Louis?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mesa to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.

Complete your trip

Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Mesa to St. Louis by cabin class

Find flights from Mesa to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Mesa and St. Louis flights

Browse other Mesa and St. Louis flight options. Last updated on October 27, 2026.

Popular flight searches

Check out other popular destinations found by fellow travelers in 2026

Other flights to St. Louis

Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 27, 2026.

Mesa to St. Louis flights

Consider these flights traveling from Mesa to St. Louis.

Top 3 airlines flying from Mesa to St. Louis

100% Free

Book with Flexibility

Travel Smart