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La Crosse

$286+ Cheap flights from North Carolina to La Crosse (LSE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/11. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — LSE
Mar 22 — Mar 291
Sun 3/22
Sun 3/29
1 adult, Economy
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Cheap flight deals from North Carolina to La Crosse

Cheapest flights from North Carolina to La Crosse
Explore the most affordable flight options available from North Carolina to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2026.

This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:48 pm
RDU
-
LSE
1 stop17h 47m
American Airlines
Fri 5/16:37 pm
LSE
-
RDU
1 stop14h 36m
American Airlines
Deal found 2/19$380
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/308:10 pm
CLT
-
LSE
1 stop4h 49m
American Airlines
Tue 7/76:00 am
LSE
-
CLT
1 stop5h 04m
American Airlines
Deal found 2/19$438
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/205:00 am
RDU
-
LSE
1 stop13h 59m
American Airlines
Fri 3/276:29 pm
LSE
-
RDU
1 stop15h 47m
American Airlines
Deal found 2/18$454
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/285:00 am
RDU
-
LSE
1 stop7h 02m
American Airlines
Sat 4/45:09 am
LSE
-
RDU
2 stops6h 14m
American Airlines
Deal found 2/19$466
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/248:15 pm
CLT
-
LSE
1 stop13h 57m
American Airlines
Sun 9/276:24 pm
LSE
-
CLT
1 stop12h 40m
American Airlines
Deal found 2/16$492
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:00 am
GSO
-
LSE
2 stops12h 59m
American Airlines
Tue 3/105:09 am
LSE
-
GSO
1 stop15h 47m
American Airlines
Deal found 2/19$507
This United Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/188:20 am
TYS
-
LSE
1 stop25h 48m
United Airlines
Sun 6/216:15 am
LSE
-
TYS
1 stop9h 46m
United Airlines
Deal found 2/18$521
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:00 pm
ORF
-
LSE
2 stops18h 05m
United Airlines
Sat 10/319:42 am
LSE
-
ORF
2 stops12h 54m
United Airlines
Deal found 2/19$547
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:30 am
GSO
-
LSE
1 stop12h 40m
United Airlines
Tue 9/18:15 pm
LSE
-
GSO
1 stop12h 59m
United Airlines
Deal found 2/17$566
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/41:00 pm
CLT
-
LSE
1 stop5h 59m
American Airlines
Sun 3/85:09 am
LSE
-
CLT
1 stop4h 09m
American Airlines
Deal found 2/17$570
This United Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:00 am
TYS
-
LSE
1 stop12h 10m
United Airlines
Wed 9/239:42 am
LSE
-
TYS
1 stop13h 33m
United Airlines
Deal found 2/16$576
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:12 am
TYS
-
LSE
2 stops10h 47m
American Airlines
Sun 6/2111:39 am
LSE
-
TYS
1 stop5h 38m
American Airlines
Deal found 2/18$594

Find flight deals from North Carolina to La Crosse

Keep the following information in mind while searching for North Carolina to La Crosse flight deals. Data was last updated February 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$380
(American Airlines)

One-way from

$286
(Kiwi.com)
Provider with most accurate pricing for Raleigh-Durham-La Crosse flight deals.
Search Deals
Provider most trusted by Cheapflights users for Raleigh-Durham-La Crosse flights.
Search Deals
From North Carolina to La Crosse
Search Deals
One-way flight from North Carolina to La Crosse
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from North Carolina to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2026.
Use the filters below to find and compare flights from North Carolina to La Crosse that are best for you.

Fly from

North Carolina

Fly to

La Crosse

Route

Depart

Return

Price

RaleighLa Crosse

RDU - LSE

RDULSE

Raleigh-Durham

Fri 4/24

4:48 pm-9:35 am

1 stop17h 47m

La Crosse

Fri 5/1

6:37 pm-10:13 am

1 stop14h 36m

$380

RaleighLa Crosse

RDU - LSE

RDULSE

Raleigh-Durham

Fri 3/20

5:00 am-5:59 pm

1 stop13h 59m

La Crosse

Fri 3/27

6:29 pm-11:16 am

1 stop15h 47m

$454

RaleighLa Crosse

RDU - LSE

RDULSE

Raleigh-Durham

Sat 3/28

5:00 am-11:02 am

1 stop7h 02m

La Crosse

Sat 4/4

5:09 am-12:23 pm

2 stops6h 14m

$466

GreensboroLa Crosse

GSO - LSE

GSOLSE

Greensboro/H. Point

Fri 3/6

6:00 am-5:59 pm

2 stops12h 59m

La Crosse

Tue 3/10

5:09 am-9:56 pm

1 stop15h 47m

$507

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Thu 6/18

8:20 am-9:08 am

1 stop25h 48m

La Crosse

Sun 6/21

6:15 am-5:01 pm

1 stop9h 46m

$521

CharlotteLa Crosse

CLT - LSE

CLTLSE

Charlotte Douglas

Wed 3/4

1:00 pm-5:59 pm

1 stop5h 59m

La Crosse

Sun 3/8

5:09 am-10:18 am

1 stop4h 09m

$570

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Thu 6/18

7:12 am-4:59 pm

2 stops10h 47m

La Crosse

Sun 6/21

11:39 am-6:17 pm

1 stop5h 38m

$594

NorfolkLa Crosse

ORF - LSE

ORFLSE

Norfolk

Wed 3/4

6:43 pm-11:01 am

1 stop17h 18m

La Crosse

Sun 3/8

6:29 pm-1:27 pm

1 stop17h 58m

$654

RaleighLa Crosse

RDU - LSE

RDULSE

Raleigh-Durham

Sat 7/11

9:45 am-4:40 pm

2 stops31h 55m

$286

NorfolkLa Crosse

ORF - LSE

ORFLSE

Norfolk

Fri 3/13

1:57 pm-11:36 pm

1 stop10h 39m

$347

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/18

Showing 1-10 of 15 results
1
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Best time to book a flight from North Carolina to La Crosse

Have a flexible travel schedule? Discover the best time to fly to La Crosse from North Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from North Carolina to La Crosse

What is the cheapest month to book a flight from North Carolina to La Crosse?

Currently, May is the cheapest month in which you can book a flight from North Carolina to La Crosse (average of $253). Flying from North Carolina to La Crosse in December is currently the most expensive (average of $534). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from North Carolina to La Crosse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to La Crosse from North Carolina?

    La Crosse (LSE) is the airport you will fly into if you book a flight from North Carolina to La Crosse. It is only a 5.4 mi journey from La Crosse (LSE) to La Crosse’s city center.

  • How long is the flight from North Carolina to La Crosse?

    There are many flights that can get you from North Carolina to La Crosse in 17h 47m. Fly via American Airlines or United Airlines to get the fastest option. North Carolina and La Crosse are separated by a distance of 859 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from North Carolina to La Crosse?

    The most popular flight routes from North Carolina to La Crosse are Charlotte Douglas - La Crosse, Greensboro/H. Point - La Crosse and Raleigh-Durham - La Crosse.

  • Can I find deals for flights from North Carolina to La Crosse that include hotel bookings?

    Yes. In addition to deals on North Carolina to La Crosse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from North Carolina to La Crosse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from North Carolina to La Crosse.

  • Can I find deals for business class flights from North Carolina to La Crosse?

    Yes. Cheapflights offers flight deals from North Carolina to La Crosse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from North Carolina to La Crosse?

    Currently, May is the cheapest month in which you can book a flight from North Carolina to La Crosse (average of $253). Flying from North Carolina to La Crosse in December is currently the most expensive (average of $534). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Decorah
Winona

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for North Carolina to La Crosse

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from North Carolina to La Crosse

Discover the top airline that operate flights from North Carolina to La Crosse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$415Average$475FlexibilityNo cancel feeOn-time71%

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