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La Crosse

$346+ Cheap flights from North Carolina to La Crosse (LSE)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/14. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — LSE
Mar 13 — Mar 201
Fri 3/13
Fri 3/20
1 adult, Economy
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Cheap flight deals from North Carolina to La Crosse

Cheapest flights from North Carolina to La Crosse
Explore the most affordable flight options available from North Carolina to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.

This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:50 am
TYS
-
LSE
1 stop11h 17m
American Airlines
Sun 4/1910:05 am
LSE
-
TYS
1 stop9h 13m
American Airlines
Deal found 2/7$346
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/254:02 pm
TYS
-
LSE
1 stop19h 59m
American Airlines
Sun 3/16:29 pm
LSE
-
TYS
1 stop21h 02m
American Airlines
Deal found 2/10$406
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:30 am
GSO
-
LSE
1 stop4h 44m
American Airlines
Sat 6/1311:44 am
LSE
-
GSO
1 stop6h 14m
American Airlines
Deal found 2/8$430
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:54 am
TYS
-
LSE
2 stops12h 13m
American Airlines
Tue 4/2810:05 am
LSE
-
TYS
2 stops10h 21m
American Airlines
Deal found 2/10$436
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:10 pm
CLT
-
LSE
1 stop4h 49m
American Airlines
Tue 8/45:25 pm
LSE
-
CLT
1 stop5h 34m
American Airlines
Deal found 2/11$438
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:11 pm
TYS
-
LSE
2 stops7h 43m
American Airlines
Sun 4/1910:05 am
LSE
-
TYS
1 stop10h 16m
American Airlines
Deal found 2/7$438
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:29 pm
RDU
-
LSE
1 stop6h 07m
American Airlines
Sat 2/285:20 am
LSE
-
RDU
1 stop4h 56m
American Airlines
Deal found 2/9$490
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/274:29 pm
RDU
-
LSE
1 stop8h 07m
American Airlines
Mon 3/96:29 pm
LSE
-
RDU
1 stop17h 35m
American Airlines
Deal found 2/10$505
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/265:00 am
RDU
-
LSE
1 stop13h 59m
American Airlines
Mon 3/26:29 pm
LSE
-
RDU
1 stop15h 37m
American Airlines
Deal found 2/10$520
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/157:40 am
TYS
-
LSE
1 stop4h 22m
American Airlines
Thu 3/1911:34 am
LSE
-
TYS
1 stop3h 57m
American Airlines
Deal found 2/10$530
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2910:23 am
CLT
-
LSE
2 stops27h 42m
United Airlines
Tue 9/19:42 am
LSE
-
CLT
2 stops24h 10m
United Airlines
Deal found 2/8$546
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/156:26 pm
CLT
-
LSE
1 stop6h 10m
American Airlines
Sat 2/215:20 am
LSE
-
CLT
1 stop7h 12m
American Airlines
Deal found 2/8$570

Find flight deals from North Carolina to La Crosse

Keep the following information in mind while searching for North Carolina to La Crosse flight deals. Data was last updated February 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$346
(American Airlines)
Provider with most accurate pricing for Raleigh-Durham-La Crosse flight deals.
Search Deals
Provider most trusted by Cheapflights users for Raleigh-Durham-La Crosse flights.
Search Deals
From North Carolina to La Crosse
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from North Carolina to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from North Carolina to La Crosse that are best for you.

Fly from

North Carolina

Fly to

La Crosse

Route

Depart

Return

Price

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Tue 4/14

7:50 am-6:07 pm

1 stop11h 17m

La Crosse

Sun 4/19

10:05 am-8:18 pm

1 stop9h 13m

$346

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Wed 4/15

7:50 am-6:07 pm

1 stop11h 17m

La Crosse

Sun 4/19

10:05 am-8:18 pm

1 stop9h 13m

$346

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Fri 4/24

11:31 am-6:07 pm

1 stop7h 36m

La Crosse

Tue 4/28

10:05 am-10:56 pm

2 stops11h 51m

$387

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Wed 2/25

4:02 pm-11:01 am

1 stop19h 59m

La Crosse

Sun 3/1

6:29 pm-4:31 pm

1 stop21h 02m

$406

GreensboroLa Crosse

GSO - LSE

GSOLSE

Greensboro/H. Point

Sat 6/6

7:30 am-11:14 am

1 stop4h 44m

La Crosse

Sat 6/13

11:44 am-6:58 pm

1 stop6h 14m

$430

CharlotteLa Crosse

CLT - LSE

CLTLSE

Charlotte Douglas

Tue 7/21

8:10 pm-11:59 pm

1 stop4h 49m

La Crosse

Tue 8/4

5:25 pm-11:59 pm

1 stop5h 34m

$438

RaleighLa Crosse

RDU - LSE

RDULSE

Raleigh-Durham

Tue 2/24

6:29 pm-11:36 pm

1 stop6h 07m

La Crosse

Sat 2/28

5:20 am-11:16 am

1 stop4h 56m

$490

RaleighLa Crosse

RDU - LSE

RDULSE

Raleigh-Durham

Fri 2/27

6:39 am-5:59 pm

1 stop12h 20m

La Crosse

Mon 3/9

6:29 pm-1:04 pm

1 stop17h 35m

$505

RaleighLa Crosse

RDU - LSE

RDULSE

Raleigh-Durham

Thu 2/26

5:00 am-5:59 pm

1 stop13h 59m

La Crosse

Mon 3/2

6:29 pm-11:06 am

1 stop15h 37m

$520

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sun 3/15

7:40 am-11:02 am

1 stop4h 22m

La Crosse

Thu 3/19

11:34 am-4:31 pm

1 stop3h 57m

$530

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/7

Showing 1-10 of 11 results
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Best time to book a flight from North Carolina to La Crosse

Have a flexible travel schedule? Discover the best time to fly to La Crosse from North Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from North Carolina to La Crosse

What is the cheapest month to book a flight from North Carolina to La Crosse?

Currently, May is the cheapest month in which you can book a flight from North Carolina to La Crosse (average of $253). Flying from North Carolina to La Crosse in December is currently the most expensive (average of $534). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from North Carolina to La Crosse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to La Crosse from North Carolina?

    La Crosse (LSE) is the airport you will fly into if you book a flight from North Carolina to La Crosse. It is only a 5.4 mi journey from La Crosse (LSE) to La Crosse’s city center.

  • How long is the flight from North Carolina to La Crosse?

    There are many flights that can get you from North Carolina to La Crosse in 11h 17m. Fly via American Airlines to get the fastest option. North Carolina and La Crosse are separated by a distance of 677 mi.

  • What are the most popular routes from North Carolina to La Crosse?

    The most popular flight routes from North Carolina to La Crosse are Charlotte Douglas - La Crosse, Raleigh-Durham - La Crosse and Greensboro/H. Point - La Crosse.

  • Can I find deals for flights from North Carolina to La Crosse that include hotel bookings?

    Yes. In addition to deals on North Carolina to La Crosse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from North Carolina to La Crosse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from North Carolina to La Crosse.

  • Can I find deals for business class flights from North Carolina to La Crosse?

    Yes. Cheapflights offers flight deals from North Carolina to La Crosse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from North Carolina to La Crosse?

    Currently, May is the cheapest month in which you can book a flight from North Carolina to La Crosse (average of $253). Flying from North Carolina to La Crosse in December is currently the most expensive (average of $534). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Decorah
Winona

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Alternative routes for North Carolina to La Crosse

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from North Carolina to La Crosse

Discover the top airline that operate flights from North Carolina to La Crosse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$415Average$478FlexibilityNo cancel feeOn-time71%

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