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$85+ Cheap flights from Santa Ana, CA to Knoxville (SNA - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/5. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — TYS
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson are usually found in August or November, booked 51 days in advance, depart on a Saturday or Wednesday and return on a Saturday

Cheap flight deals from Santa Ana to Knoxville

Cheapest flights from Santa Ana to Knoxville
Explore the most affordable flight options available from Santa Ana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This Delta deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/138:00 amSNA - TYS
1 stop8h 03mDelta
Tue 12/166:00 pmTYS - SNA
1 stop7h 30mDelta
Deal found 12/9$429
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/171:35 pmSNA - TYS
1 stop20h 36mMultiple Airlines
Wed 12/316:07 pmTYS - SNA
2 stops43h 09mMultiple Airlines
Deal found 12/9$482
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:45 amSNA - TYS
2 stops34h 54mMultiple Airlines
Sun 1/42:01 pmTYS - SNA
1 stop21h 26mMultiple Airlines
Deal found 12/9$507
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:16 pmSNA - TYS
2 stops16h 35mMultiple Airlines
Thu 1/11:10 pmTYS - SNA
1 stop22h 17mMultiple Airlines
Deal found 12/10$511
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/131:19 pmSNA - TYS
1 stop6h 11mUnited Airlines
Tue 12/167:05 amTYS - SNA
1 stop7h 08mUnited Airlines
Deal found 12/10$519
This American Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/131:28 pmSNA - TYS
2 stops7h 31mAmerican Airlines
Tue 12/165:24 amTYS - SNA
1 stop9h 24mAmerican Airlines
Deal found 12/9$524
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1711:10 amSNA - TYS
2 stops9h 34mUnited Airlines
Wed 12/319:50 amTYS - SNA
2 stops10h 58mUnited Airlines
Deal found 12/9$529
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/173:01 pmSNA - TYS
1 stop5h 58mAmerican Airlines
Wed 12/315:23 amTYS - SNA
1 stop7h 35mAmerican Airlines
Deal found 12/11$536
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1811:11 amSNA - TYS
1 stop26h 51mMultiple Airlines
Sat 12/206:13 pmTYS - SNA
2 stops31h 14mMultiple Airlines
Deal found 12/9$538
This Mytrip deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:45 amSNA - TYS
1 stop7h 17mMultiple Airlines
Mon 12/298:00 amTYS - SNA
1 stop17h 11mMultiple Airlines
Deal found 12/9$545
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2911:09 amSNA - TYS
1 stop7h 20mAmerican Airlines
Thu 1/15:23 amTYS - SNA
1 stop7h 35mAmerican Airlines
Deal found 12/10$553

Find flight deals from Santa Ana to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(Kiwi.com)

One-way from

$85
(Trip.com)

Popular in

December

Cheapest in

August

Average price

$498
Provider with most accurate pricing for Santa Ana J. Wayne/Orange Cnty-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santa Ana J. Wayne/Orange Cnty-Knoxville McGhee Tyson flights.
Search Deals
From Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
Search Deals
One-way flight from Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
Search Deals
High demand for flights, 1% potential price rise
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Ana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Santa Ana to Knoxville that are best for you.

Fly from

Santa Ana

Fly to

Knoxville

Route

Depart

Return

Price

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 1/10

12:59 pm-11:45 pm

1 stop7h 46m

Knoxville McGhee Tyson

Wed 1/14

5:40 am-11:49 am

1 stop9h 09m

$289

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 2/18

6:45 am-3:40 pm

1 stop5h 55m

Knoxville McGhee Tyson

Sat 2/21

12:20 pm-7:03 pm

2 stops9h 43m

$294

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 1/10

11:05 am-11:44 pm

2 stops9h 39m

Knoxville McGhee Tyson

Wed 1/14

4:25 pm-9:18 pm

1 stop7h 53m

$294

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 1/7

11:11 am-3:28 pm

2 stops25h 17m

Knoxville McGhee Tyson

Sun 1/11

4:23 pm-11:22 am

1 stop21h 59m

$300

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 1/8

4:16 pm-4:50 pm

1 stop21h 34m

Knoxville McGhee Tyson

Tue 1/13

1:00 pm-3:42 pm

2 stops29h 42m

$309

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Fri 1/9

6:45 am-4:50 pm

1 stop7h 05m

Knoxville McGhee Tyson

Tue 1/13

1:00 pm-3:42 pm

2 stops29h 42m

$315

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 1/10

6:45 am-8:39 am

3 stops22h 54m

Knoxville McGhee Tyson

Wed 1/14

4:47 pm-12:25 pm

2 stops22h 38m

$319

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 1/8

4:37 pm-1:40 pm

2 stops18h 03m

Knoxville McGhee Tyson

Sun 1/11

4:23 pm-11:22 am

1 stop21h 59m

$334

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 2/5

11:53 am-3:30 pm

1 stop24h 37m

$85

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 2/5

1:20 pm-3:30 pm

2 stops23h 10m

$118

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/9

Showing 1-10 of 15 results
1
2

Compare providers for flights from Santa Ana to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Knoxville in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santa Ana, California-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santa Ana, California-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Ana, California-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Ana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Knoxville

How far ahead should I book a flight from Santa Ana, California to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Santa Ana to Knoxville. Price data was last updated on December 5, 2025.

Booking 51 days in advance of your planned departure date is, on average, the best time to get cheap flights from Santa Ana, California to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Santa Ana, California to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Santa Ana, California to Knoxville (average of $42). Flying from Santa Ana, California to Knoxville in June is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SNA to TYS?

Find hourly flight availability from Santa Ana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

It’s optimal to fly from Santa Ana, California to Knoxville at noon. By choosing this option you can save up to 15% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 12, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Santa Ana to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.1

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.1

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
United Airlines
7.4
Good
9,095 reviews
Delta
7.9
Good
8,007 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.1

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,007 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.1

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Ana, California to Knoxville?

    Airlines like Delta, American Airlines, and United Airlines fly from Santa Ana, California to Knoxville in about 5h 55m. The time it takes to get you to your destination can typically vary by up to 3h 44m. The distance from Santa Ana, California to Knoxville is about 1918 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Santa Ana, California to Knoxville round-trip?

    Delta, at $174, was found to be the cheapest airline from Santa Ana, California to Knoxville.Alternate airlines to your destination round-trip include United Airlines and American Airlines. Delta is priced at 58% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Santa Ana, California to Knoxville one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $69. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Santa Ana, California to Knoxville for a low price.

  • Can I find deals for flights from Santa Ana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Knoxville.

  • Can I find deals for business class flights from Santa Ana to Knoxville?

    Yes. Cheapflights offers flight deals from Santa Ana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana, California to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Santa Ana, California to Knoxville (average of $42). Flying from Santa Ana, California to Knoxville in June is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Santa Ana to Knoxville

Discover the top 3 airlines that operate flights from Santa Ana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$239Average$450FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$263Average$449FlexibilityNo cancel feeOn-time71%
DeltaCheapest$276Average$363FlexibilityNo cancel feeOn-timeN/A

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