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$120+ Cheap flights from Santa Ana to Knoxville (SNA - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — TYS
oct. 11 — oct. 181
sáb. 10/11
sáb. 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson are usually found in August or January, booked 26 days in advance, depart on a Saturday or Wednesday and return on a Saturday

Cheap flight deals from Santa Ana to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 11, 2025.

Round-trip from

$242
(Kiwi.com)

One-way from

$120
(Kiwi.com)

Popular in

May

Cheapest in

August

Average price

$393
From Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
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One-way flight from Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 8% potential increase in price ($39 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Santa Ana to Knoxville

Cheapest flights from Santa Ana to Knoxville
Explore the most affordable flight options available from Santa Ana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 11, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/257:16 pmSNA - TYS
1 stop24h 14mMultiple Airlines
lun. 9/298:30 amTYS - SNA
1 stop16h 35mMultiple Airlines
Deal found 9/10$242
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/110:30 amSNA - TYS
1 stop7h 03mUnited Airlines
mar. 11/45:52 pmTYS - SNA
1 stop7h 21mUnited Airlines
Deal found 9/10$243
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/12:20 pmSNA - TYS
1 stop21h 13mMultiple Airlines
mar. 11/43:56 pmTYS - SNA
2 stops32h 03mMultiple Airlines
Deal found 9/11$265
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/112:44 pmSNA - TYS
1 stop8h 39mAmerican Airlines
mar. 11/412:46 pmTYS - SNA
2 stops10h 17mAmerican Airlines
Deal found 9/11$271
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/21:00 pmSNA - TYS
1 stop21h 23mMultiple Airlines
dom. 10/55:44 pmTYS - SNA
2 stops28h 30mMultiple Airlines
Deal found 9/10$288
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/3111:10 amSNA - TYS
2 stops8h 45mUnited Airlines
mar. 11/44:58 pmTYS - SNA
1 stop8h 21mUnited Airlines
Deal found 9/10$296
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/36:45 amSNA - TYS
2 stops24h 33mMultiple Airlines
vie. 10/108:17 pmTYS - SNA
1 stop20h 18mMultiple Airlines
Deal found 9/11$311
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/246:45 amSNA - TYS
1 stop7h 33mUnited Airlines
mar. 10/281:52 pmTYS - SNA
1 stop7h 55mUnited Airlines
Deal found 9/10$320

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Ana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
Use the filters below to find and compare flights from Santa Ana to Knoxville that are best for you.

Fly from

Santa Ana

Fly to

Knoxville

Route

Depart

Return

Price

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

sáb. 11/1

10:30 am-8:33 pm

1 stop7h 03m

Knoxville McGhee Tyson

mar. 11/4

5:52 pm-10:13 pm

1 stop7h 21m

$243

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

sáb. 11/1

12:44 pm-12:23 am

1 stop8h 39m

Knoxville McGhee Tyson

mar. 11/4

12:46 pm-8:03 pm

2 stops10h 17m

$271

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

vie. 10/31

11:10 am-10:55 pm

2 stops8h 45m

Knoxville McGhee Tyson

mar. 11/4

4:58 pm-10:19 pm

1 stop8h 21m

$296

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

sáb. 10/18

2:51 pm-12:23 am

1 stop6h 32m

Knoxville McGhee Tyson

vie. 10/24

7:05 am-10:35 am

1 stop6h 30m

$320

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

mié. 2/18

12:52 pm-11:40 pm

1 stop7h 48m

Knoxville McGhee Tyson

sáb. 2/21

5:51 am-10:25 am

1 stop7h 34m

$333

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

lun. 10/20

2:35 pm-3:06 pm

2 stops21h 31m

Knoxville McGhee Tyson

vie. 10/24

6:00 am-8:13 pm

1 stop17h 13m

$343

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

mié. 11/5

1:27 pm-12:08 am

2 stops7h 41m

Knoxville McGhee Tyson

sáb. 11/8

6:30 am-3:20 pm

2 stops11h 50m

$366

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

mié. 11/5

11:48 am-9:13 pm

1 stop6h 25m

Knoxville McGhee Tyson

lun. 11/10

3:51 pm-10:28 pm

1 stop9h 37m

$368

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

sáb. 10/25

2:20 pm-1:33 pm

1 stop20h 13m

$120

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

sáb. 10/25

8:40 am-10:50 pm

2 stops11h 10m

$127

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 17 results
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Best time to book a flight from Santa Ana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Knoxville

How far ahead should I book a flight from Santa Ana to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Santa Ana to Knoxville. Price data was last updated on August 29, 2025.

The price you pay for your flight from Santa Ana to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 26 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santa Ana to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Santa Ana to Knoxville (average of $294). Flying from Santa Ana to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SNA to TYS?

Find hourly flight availability from Santa Ana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 11, 2025.

It’s optimal to fly from Santa Ana to Knoxville at noon. By choosing this option you can save up to 16% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated septiembre 11, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Santa Ana to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Ana to Knoxville?

    There are many flights that can get you from Santa Ana to Knoxville in 7h 03m. Fly via United Airlines or American Airlines to get the fastest option. Airlines will cover a distance of 1918 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Santa Ana to Knoxville round-trip?

    Cheapflights users have booked flights from Santa Ana to Knoxville round-trip from $192. Other airlines that can offer you cheap pricing are United Airlines, from $239, and American Airlines, from $277. Users have found that Delta is 54% cheaper than the other options available to this destination.

  • Can I find deals for flights from Santa Ana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Knoxville.

  • Can I find deals for business class flights from Santa Ana to Knoxville?

    Yes. Cheapflights offers flight deals from Santa Ana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Santa Ana to Knoxville (average of $294). Flying from Santa Ana to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Santa Ana to Knoxville

Discover the top 3 airlines that operate flights from Santa Ana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$192Average$363FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$239Average$495FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$277Average$435FlexibilityNo cancel feeOn-time71%

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