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$127+ Cheap flights from Santa Ana to Knoxville (SNA - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/28. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — TYS
May 4 — May 111
Sun 5/4
Sun 5/11
1 adult, Economy
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Cheapflights Tip: The best prices from Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson are usually found in January or March, booked 18 days in advance, depart on a Saturday or Wednesday and return on a Saturday

Cheap flight deals from Santa Ana to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 29, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$288
(Delta)

One-way from

$127
(CheapOair)

Popular in

June

Cheapest in

January

Average price

$433
Provider with most accurate pricing for Santa Ana J. Wayne/Orange Cnty-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Santa Ana J. Wayne/Orange Cnty-Knoxville McGhee Tyson flights.
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From Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
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One-way flight from Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($118 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Santa Ana to Knoxville

Cheapest flights from Santa Ana to Knoxville
Explore the most affordable flight options available from Santa Ana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/49:46 amSNA - TYS
2 stops10h 58mDelta
Fri 7/255:57 pmTYS - SNA
1 stop7h 11mDelta
Deal found 4/27$288
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/47:30 amSNA - TYS
1 stop7h 30mAmerican Airlines
Fri 7/256:00 amTYS - SNA
1 stop6h 24mAmerican Airlines
Deal found 4/27$344
This Mytrip deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/126:45 amSNA - TYS
1 stop12h 14mMultiple Airlines
Fri 5/162:14 pmTYS - SNA
1 stop10h 03mMultiple Airlines
Deal found 4/27$352
This CheapOair deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1112:01 pmSNA - TYS
1 stop25h 28mFrontier
Sun 6/155:25 pmTYS - SNA
1 stop20h 51mFrontier
Deal found 4/27$362
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/48:40 amSNA - TYS
2 stops12h 04mUnited Airlines
Fri 9/125:45 amTYS - SNA
2 stops14h 41mUnited Airlines
Deal found 4/27$389
This Alaska Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/186:45 amSNA - TYS
2 stops12h 05mAlaska Airlines
Mon 6/238:05 amTYS - SNA
2 stops17h 25mAlaska Airlines
Deal found 4/26$904

Cheapflights Fare Finder

Customize your flight search to find flights from Santa Ana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
Use the filters below to find and compare flights from Santa Ana to Knoxville that are best for you.

Fly from

Santa Ana

Fly to

Knoxville

Route

Depart

Return

Price

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Fri 7/4

9:46 am-11:44 pm

2 stops10h 58m

Knoxville McGhee Tyson

Fri 7/25

5:57 pm-10:08 pm

1 stop7h 11m

$288

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Fri 7/4

7:30 am-6:00 pm

1 stop7h 30m

Knoxville McGhee Tyson

Fri 7/25

6:00 am-9:24 am

1 stop6h 24m

$344

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 5/12

6:45 am-9:59 pm

1 stop12h 14m

Knoxville McGhee Tyson

Fri 5/16

2:14 pm-9:17 pm

1 stop10h 03m

$352

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 6/11

12:01 pm-4:29 pm

1 stop25h 28m

Knoxville McGhee Tyson

Sun 6/15

5:25 pm-11:16 am

1 stop20h 51m

$362

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 9/4

8:40 am-11:44 pm

2 stops12h 04m

Knoxville McGhee Tyson

Fri 9/12

5:45 am-5:26 pm

2 stops14h 41m

$389

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 9/24

6:45 am-11:49 pm

2 stops14h 04m

Knoxville McGhee Tyson

Mon 9/29

6:08 am-5:09 pm

2 stops14h 01m

$544

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 5/28

12:01 pm-4:35 pm

1 stop25h 34m

$127

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 5/19

7:55 am-6:02 pm

1 stop7h 07m

$270

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sun 6/22

2:35 pm-11:59 pm

1 stop6h 24m

$300

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 6/11

5:53 pm-2:33 pm

3 stops17h 40m

$434

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Compare providers for flights from Santa Ana to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Knoxville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
CheapOairPrice Accuracy1 starTrust Score*3 stars
CheapfaremartPrice Accuracy-Trust Score*1 star
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santa Ana-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Ana-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Ana-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Ana-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Ana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Knoxville

How far ahead should I book a flight from Santa Ana to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Santa Ana to Knoxville. Price data was last updated on April 25, 2025.

The price you pay for your flight from Santa Ana to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 18 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santa Ana to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Santa Ana to Knoxville (average of $296). Flying from Santa Ana to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SNA to TYS?

Find hourly flight availability from Santa Ana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 29, 2025.

It’s optimal to fly from Santa Ana to Knoxville at noon. By choosing this option you can save up to 16% on the cost of your flight, compared to a flight in the morning.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 29, 2025.
Read through reviews of airlines operating flights from Santa Ana to Knoxville, such as Alaska Airlines, Delta and United Airlines. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Boarding

8.2

Food

7.1

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
9,949 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Boarding

8.2

Food

7.1

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,929 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Boarding

8.2

Food

7.1

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,696 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Boarding

8.2

Food

7.1

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Boarding

8.2

Food

7.1

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Frontier
6.0
Okay
3,285 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Boarding

8.2

Food

7.1

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Santa Ana to Knoxville round-trip?

    Cheapflights users have booked flights from Santa Ana to Knoxville round-trip from $288. Other airlines that can offer you cheap pricing are American Airlines, from $344, and Frontier, from $362. Users have found that Delta is 38% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Santa Ana to Knoxville one-way?

    $127 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $270 and $300, respectively.

  • Can I find deals for flights from Santa Ana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Knoxville.

  • Can I find deals for business class flights from Santa Ana to Knoxville?

    Yes. Cheapflights offers flight deals from Santa Ana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Santa Ana to Knoxville (average of $296). Flying from Santa Ana to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

Book flights to Santa Ana if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Top 3 airlines flying from Santa Ana to Knoxville

Discover the top 3 airlines that operate flights from Santa Ana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$228Average$511FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$261Average$435FlexibilityNo cancel feeOn-time71%
DeltaCheapest$276Average$398FlexibilityNo cancel feeOn-timeN/A

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