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$97+ Cheap flights from Santa Ana, CA to Knoxville (SNA - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/8. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — TYS
Nov 26 — Dec 31
Wed 11/26
Wed 12/3
1 adult, Economy
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Cheapflights Tip: The best prices from Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson are usually found in August or September, booked 26 days in advance, depart on a Saturday or Wednesday and return on a Saturday

Cheap flight deals from Santa Ana to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 27, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$272
(Kiwi.com)

One-way from

$97
(Booking.com)

Popular in

May

Cheapest in

August

Average price

$466
Provider with most accurate pricing for Santa Ana J. Wayne/Orange Cnty-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Santa Ana J. Wayne/Orange Cnty-Knoxville McGhee Tyson flights.
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From Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
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One-way flight from Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 7% potential increase in price ($33 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Santa Ana to Knoxville

Cheapest flights from Santa Ana to Knoxville
Explore the most affordable flight options available from Santa Ana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/255:46 pmSNA - TYS
1 stop25h 22mMultiple Airlines
Mon 12/84:52 pmTYS - SNA
1 stop22h 50mMultiple Airlines
Deal found 10/26$290
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/911:12 amSNA - TYS
1 stop8h 46mMultiple Airlines
Thu 11/137:17 pmTYS - SNA
1 stop18h 59mMultiple Airlines
Deal found 10/24$298
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/163:01 pmSNA - TYS
1 stop5h 58mAmerican Airlines
Mon 12/226:20 pmTYS - SNA
1 stop7h 20mAmerican Airlines
Deal found 10/27$381
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/118:15 amSNA - TYS
1 stop6h 49mUnited Airlines
Sat 11/154:50 pmTYS - SNA
1 stop7h 03mUnited Airlines
Deal found 10/26$409
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/117:00 pmSNA - TYS
2 stops11h 37mDelta
Sat 11/151:27 pmTYS - SNA
1 stop8h 09mDelta
Deal found 10/26$414
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/41:15 pmSNA - TYS
1 stop7h 03mDelta
Mon 12/83:57 pmTYS - SNA
1 stop9h 33mDelta
Deal found 10/27$437
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/188:55 amSNA - TYS
1 stop9h 22mAmerican Airlines
Sat 11/224:27 pmTYS - SNA
1 stop9h 23mAmerican Airlines
Deal found 10/27$442

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Ana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 27, 2025.
Use the filters below to find and compare flights from Santa Ana to Knoxville that are best for you.

Fly from

Santa Ana

Fly to

Knoxville

Route

Depart

Return

Price

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 2/18

3:12 pm-12:13 am

1 stop6h 01m

Knoxville McGhee Tyson

Sat 2/21

4:29 pm-8:24 pm

1 stop6h 55m

$289

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 11/25

5:46 pm-10:08 pm

1 stop25h 22m

Knoxville McGhee Tyson

Mon 12/8

4:52 pm-12:42 pm

1 stop22h 50m

$290

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 2/18

7:00 am-11:00 pm

2 stops13h 00m

Knoxville McGhee Tyson

Sat 2/21

10:05 am-8:44 pm

2 stops13h 39m

$324

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 1/22

12:12 pm-5:28 pm

2 stops26h 16m

Knoxville McGhee Tyson

Sun 1/25

10:00 am-1:56 pm

1 stop6h 56m

$340

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 1/22

9:00 am-9:02 pm

2 stops9h 02m

Knoxville McGhee Tyson

Sat 1/24

1:59 pm-6:41 pm

1 stop7h 42m

$368

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 11/8

2:20 pm-6:22 pm

1 stop25h 02m

$97

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sun 12/14

10:10 am-10:22 pm

1 stop9h 12m

$131

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 12/13

1:35 pm-3:57 pm

1 stop23h 22m

$132

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 12/13

8:19 pm-7:14 pm

3 stops43h 55m

$167

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 11/8

1:31 pm-4:49 pm

2 stops24h 18m

$189

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/25

Showing 1-10 of 14 results
1
2

Compare providers for flights from Santa Ana to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Knoxville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santa Ana, California-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santa Ana, California-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Ana, California-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Ana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Knoxville

How far ahead should I book a flight from Santa Ana, California to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Santa Ana to Knoxville. Price data was last updated on October 24, 2025.

Booking 26 days in advance of your planned departure date is, on average, the best time to get cheap flights from Santa Ana, California to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Santa Ana, California to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Santa Ana, California to Knoxville (average of $42). Flying from Santa Ana, California to Knoxville in June is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SNA to TYS?

Find hourly flight availability from Santa Ana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 27, 2025.

It’s optimal to fly from Santa Ana, California to Knoxville at noon. By choosing this option you can save up to 15% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 27, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Santa Ana to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,996 reviews

Food

7.3

Crew

8.5

Boarding

8.2

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Delta
7.9
Good
7,996 reviews
Delta
7.9
Good
7,996 reviews

Food

7.3

Crew

8.5

Boarding

8.2

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
United Airlines
7.4
Good
8,997 reviews
Delta
7.9
Good
7,996 reviews

Food

7.3

Crew

8.5

Boarding

8.2

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
American Airlines
7.2
Good
11,033 reviews
Delta
7.9
Good
7,996 reviews

Food

7.3

Crew

8.5

Boarding

8.2

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Ana, California to Knoxville?

    Airlines like American Airlines fly from Santa Ana, California to Knoxville in about 6h 01m. The time it takes to get you to your destination can typically vary by up to . The distance from Santa Ana, California to Knoxville is about 1918 mi.

  • What are the cheapest airlines flying from Santa Ana, California to Knoxville round-trip?

    United Airlines, at $239, was found to be the cheapest airline from Santa Ana, California to Knoxville.Alternate airlines to your destination round-trip include Delta and American Airlines. United Airlines is priced at 42% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Santa Ana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Knoxville.

  • Can I find deals for business class flights from Santa Ana to Knoxville?

    Yes. Cheapflights offers flight deals from Santa Ana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana, California to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Santa Ana, California to Knoxville (average of $42). Flying from Santa Ana, California to Knoxville in June is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Santa Ana to Knoxville

Discover the top 3 airlines that operate flights from Santa Ana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$239Average$495FlexibilityNo cancel feeOn-time69%
DeltaCheapest$276Average$363FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$277Average$440FlexibilityNo cancel feeOn-time71%

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