Knoxville

$139+ Cheap flights from Santa Ana to Knoxville (SNA - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/2. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — TYS
Apr 9 — Apr 161
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Cheap flight deals from Santa Ana to Knoxville

Cheapest flights from Santa Ana to Knoxville
Explore the most affordable flight options available from Santa Ana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This Frontier deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:10 pm
SNA
-
TYS
1 stop24h 23m
Frontier
Sun 5/104:28 pm
TYS
-
SNA
1 stop21h 18m
Frontier
Deal found 3/7$233
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:10 pm
SNA
-
TYS
2 stops31h 23m
Multiple Airlines
Sun 5/104:28 pm
TYS
-
SNA
1 stop21h 18m
Multiple Airlines
Deal found 3/7$297
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1512:15 pm
SNA
-
TYS
1 stop8h 26m
United Airlines
Sat 5/94:20 pm
TYS
-
SNA
1 stop7h 24m
United Airlines
Deal found 3/5$299
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:45 am
SNA
-
TYS
1 stop8h 19m
American Airlines
Tue 4/211:20 pm
TYS
-
SNA
1 stop8h 09m
American Airlines
Deal found 3/6$309
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:15 am
SNA
-
TYS
2 stops9h 20m
Southwest
Sat 5/93:55 pm
TYS
-
SNA
1 stop6h 20m
Southwest
Deal found 3/5$310
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/259:00 am
SNA
-
TYS
2 stops10h 34m
United Airlines
Wed 4/299:00 am
TYS
-
SNA
1 stop7h 36m
United Airlines
Deal found 3/6$314
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/251:11 pm
SNA
-
TYS
1 stop7h 43m
Delta
Wed 4/295:35 am
TYS
-
SNA
1 stop9h 26m
Delta
Deal found 3/5$354
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:53 pm
SNA
-
TYS
2 stops16h 43m
Multiple Airlines
Thu 4/98:00 am
TYS
-
SNA
1 stop29h 05m
Multiple Airlines
Deal found 3/5$360
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/22:53 pm
SNA
-
TYS
2 stops29h 27m
Multiple Airlines
Mon 4/61:33 pm
TYS
-
SNA
1 stop10h 40m
Multiple Airlines
Deal found 3/7$364
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/141:23 pm
SNA
-
TYS
1 stop7h 33m
American Airlines
Fri 4/173:58 pm
TYS
-
SNA
1 stop8h 16m
American Airlines
Deal found 3/8$373

Find flight deals from Santa Ana to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$233
(Frontier)

One-way from

$139
(Kiwi.com)

Popular in

March

Cheapest in

August

Average price

$569
Provider with most accurate pricing for Santa Ana J. Wayne/Orange Cnty-Knoxville McGhee Tyson flight deals.
Provider most trusted by Cheapflights users for Santa Ana J. Wayne/Orange Cnty-Knoxville McGhee Tyson flights.
From Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
One-way flight from Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
Highest demand for flights based on searches. 11% potential increase in price ($57 potential increase over avg. RT price).
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Average for round-trip flights in March 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Ana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Santa Ana to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 4/15

9:00 am-11:08 pm

2 stops11h 08m

Knoxville McGhee Tyson

Tue 4/21

5:53 pm-10:35 pm

1 stop7h 42m

$384

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 5/2

7:00 am-8:45 pm

2 stops10h 45m

Knoxville McGhee Tyson

Tue 5/5

5:55 pm-10:35 pm

1 stop7h 40m

$404
Quickest round-trip

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 5/2

6:45 am-4:54 pm

1 stop7h 09m

Knoxville McGhee Tyson

Thu 5/7

4:20 pm-8:44 pm

1 stop7h 24m

$421

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 5/20

6:45 am-7:40 pm

2 stops9h 55m

Knoxville McGhee Tyson

Sun 5/24

4:40 pm-9:55 pm

1 stop8h 15m

$428

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 5/27

7:45 am-6:07 pm

1 stop7h 22m

Knoxville McGhee Tyson

Sat 5/30

8:20 am-8:55 pm

2 stops15h 35m

$440

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 3/31

12:15 pm-11:41 pm

1 stop8h 26m

Knoxville McGhee Tyson

Wed 4/1

7:05 am-11:13 am

1 stop7h 08m

$463

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 4/4

7:45 pm-12:55 pm

2 stops14h 10m

Knoxville McGhee Tyson

Wed 4/8

2:55 pm-9:45 pm

2 stops9h 50m

$473
Cheapest one-way

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 4/28

10:50 am-10:34 pm

1 stop8h 44m

$155

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 4/27

9:20 pm-9:22 am

1 stop9h 02m

$159

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 5/23

8:00 am-7:31 pm

1 stop8h 31m

$200

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/6

Showing 1-10 of 14 resultsSorted by cheapest first
1
2

Compare providers for flights from Santa Ana to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Knoxville in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santa Ana-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Ana-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Ana-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Ana-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Ana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Knoxville

How far ahead should I book a flight from Santa Ana to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Santa Ana to Knoxville. Price data was last updated on March 6, 2026.

The price you pay for your flight from Santa Ana to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 51 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santa Ana to Knoxville?

Currently, September is the cheapest month in which you can book a flight from Santa Ana to Knoxville (average of $186). Flying from Santa Ana to Knoxville in March is currently the most expensive (average of $296). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 10, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Santa Ana to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Food

7.2

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Overall

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Food

7.2

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Overall

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Food

7.2

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Overall

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Food

7.2

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Overall

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How long is the flight from Santa Ana to Knoxville?

    There are many flights that can get you from Santa Ana to Knoxville in 11h 08m. Fly via United Airlines to get the fastest option. Airlines will cover a distance of 1918 mi.

  • What are the cheapest airlines flying from Santa Ana to Knoxville round-trip?

    Cheapflights users have booked flights from Santa Ana to Knoxville round-trip from $174. Other airlines that can offer you cheap pricing are American Airlines, from $283, and United Airlines, from $288. Users have found that Delta is 60% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Santa Ana to Knoxville one-way?

    $69 is the cheapest one-way deal found within the past few days, from United Airlines. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $138 and $159, respectively.

  • Can I find deals for flights from Santa Ana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Knoxville.

  • Can I find deals for business class flights from Santa Ana to Knoxville?

    Yes. Cheapflights offers flight deals from Santa Ana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana to Knoxville?

    Currently, September is the cheapest month in which you can book a flight from Santa Ana to Knoxville (average of $186). Flying from Santa Ana to Knoxville in March is currently the most expensive (average of $296). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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Alternative routes for Santa Ana to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Santa Ana to Knoxville

Discover the top 3 airlines that operate flights from Santa Ana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$174Average$363FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$283Average$462FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$288Average$448FlexibilityNo cancel feeOn-time69%

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