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$172+ Cheap flights from Santa Ana to Knoxville (SNA - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/26. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — TYS
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheapflights Tip: The best prices from Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson are usually found in August or January, booked 18 days in advance, depart on a Saturday or Wednesday and return on a Saturday

Cheap flight deals from Santa Ana to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$252
(Mytrip)

One-way from

$172
(Mytrip)

Popular in

June

Cheapest in

August

Average price

$548
From Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
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One-way flight from Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 10% potential increase in price ($52 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Santa Ana to Knoxville

Cheapest flights from Santa Ana to Knoxville
Explore the most affordable flight options available from Santa Ana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/113:31 pmSNA - TYS
1 stop27h 59mMultiple Airlines
Mon 9/158:30 amTYS - SNA
1 stop28h 31mMultiple Airlines
Deal found 6/10$228
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/811:51 amSNA - TYS
1 stop6h 40mAmerican Airlines
Tue 11/114:33 pmTYS - SNA
1 stop8h 39mAmerican Airlines
Deal found 6/11$289
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1312:03 pmSNA - TYS
1 stop8h 45mDelta
Sat 8/161:00 pmTYS - SNA
2 stops12h 23mDelta
Deal found 6/11$294
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/218:00 amSNA - TYS
2 stops12h 57mUnited Airlines
Thu 9/47:20 amTYS - SNA
1 stop6h 45mUnited Airlines
Deal found 6/11$384
This Alaska Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/47:00 amSNA - TYS
2 stops13h 51mAlaska Airlines
Mon 9/84:37 pmTYS - SNA
2 stops20h 12mAlaska Airlines
Deal found 6/10$414

Cheapflights Fare Finder

Customize your flight search to find flights from Santa Ana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Santa Ana to Knoxville that are best for you.

Fly from

Santa Ana

Fly to

Knoxville

Route

Depart

Return

Price

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 7/9

12:26 pm-8:04 pm

2 stops28h 38m

Knoxville McGhee Tyson

Mon 7/14

2:28 pm-11:26 am

1 stop23h 58m

$252

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 8/13

12:28 pm-12:19 am

1 stop8h 51m

Knoxville McGhee Tyson

Sat 8/16

3:04 pm-9:20 pm

1 stop9h 16m

$289

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 8/13

12:03 pm-11:48 pm

1 stop8h 45m

Knoxville McGhee Tyson

Sat 8/16

1:00 pm-10:23 pm

2 stops12h 23m

$294

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 8/21

8:00 am-11:57 pm

2 stops12h 57m

Knoxville McGhee Tyson

Mon 8/25

4:40 pm-10:12 pm

1 stop8h 32m

$384

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 9/4

7:00 am-11:51 pm

2 stops13h 51m

Knoxville McGhee Tyson

Mon 9/8

4:37 pm-9:49 am

2 stops20h 12m

$414

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 6/26

7:40 pm-1:38 pm

1 stop14h 58m

$172

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 6/30

2:40 pm-11:59 pm

1 stop6h 19m

$273

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 6/30

6:40 pm-10:27 am

2 stops12h 47m

$278

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 7/28

2:20 pm-11:59 pm

1 stop6h 39m

$280

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 6/25

7:14 pm-11:47 am

2 stops13h 33m

$545

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/12

Best time to book a flight from Santa Ana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Knoxville

How far ahead should I book a flight from Santa Ana to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Santa Ana to Knoxville. Price data was last updated on June 9, 2025.

The price you pay for your flight from Santa Ana to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 18 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santa Ana to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Santa Ana to Knoxville (average of $296). Flying from Santa Ana to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SNA to TYS?

Find hourly flight availability from Santa Ana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

It’s optimal to fly from Santa Ana to Knoxville at noon. By choosing this option you can save up to 16% on the cost of your flight, compared to a flight in the morning.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 12, 2025.
Read through reviews of airlines operating flights from Santa Ana to Knoxville, such as Alaska Airlines, Delta and United Airlines. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Overall

8.0

Food

7.1

Comfort

7.8

Entertainment

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Overall

8.0

Food

7.1

Comfort

7.8

Entertainment

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,946 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Overall

8.0

Food

7.1

Comfort

7.8

Entertainment

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,790 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Overall

8.0

Food

7.1

Comfort

7.8

Entertainment

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Overall

8.0

Food

7.1

Comfort

7.8

Entertainment

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Santa Ana to Knoxville round-trip?

    Cheapflights users have booked flights from Santa Ana to Knoxville round-trip from $289. Other airlines that can offer you cheap pricing are Delta, from $294, and United Airlines, from $384. Users have found that American Airlines is 33% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Santa Ana to Knoxville one-way?

    $273 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on United Airlines and Delta, with prices starting from $278 and $280, respectively.

  • Can I find deals for flights from Santa Ana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Knoxville.

  • Can I find deals for business class flights from Santa Ana to Knoxville?

    Yes. Cheapflights offers flight deals from Santa Ana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Santa Ana to Knoxville (average of $296). Flying from Santa Ana to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

Book flights to Santa Ana if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Top 3 airlines flying from Santa Ana to Knoxville

Discover the top 3 airlines that operate flights from Santa Ana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$228Average$457FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$264Average$424FlexibilityNo cancel feeOn-time71%
DeltaCheapest$276Average$397FlexibilityNo cancel feeOn-timeN/A

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