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Knoxville

$109+ Cheap flights from San Antonio to Knoxville (SAT - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/11. Fares are subject to change and may not be available on all flights or dates of travel.
SAT — TYS
Jan 30 — Feb 61
Fri 1/30
Fri 2/6
1 adult, Economy
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Cheap flight deals from San Antonio to Knoxville

Cheapest flights from San Antonio to Knoxville
Explore the most affordable flight options available from San Antonio to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 31, 2025.

This United Airlines deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:15 amSAT - TYS
1 stop4h 56mUnited Airlines
Thu 1/19:05 amTYS - SAT
1 stop5h 12mUnited Airlines
Deal found 12/29$217
This American Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amSAT - TYS
1 stop4h 28mAmerican Airlines
Thu 1/15:23 amTYS - SAT
1 stop6h 33mAmerican Airlines
Deal found 12/30$273
This American Airlines deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3010:08 amSAT - TYS
1 stop6h 52mAmerican Airlines
Tue 1/65:36 pmTYS - SAT
1 stop7h 23mAmerican Airlines
Deal found 12/29$329
This American Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:00 pmSAT - TYS
1 stop4h 45mAmerican Airlines
Sat 1/35:23 amTYS - SAT
1 stop5h 15mAmerican Airlines
Deal found 12/30$378
This United Airlines deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:05 pmSAT - TYS
1 stop6h 37mUnited Airlines
Sat 1/311:58 amTYS - SAT
1 stop4h 55mUnited Airlines
Deal found 12/29$399
This American Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amSAT - TYS
1 stop4h 28mAmerican Airlines
Sat 1/35:23 amTYS - SAT
1 stop5h 15mAmerican Airlines
Deal found 12/30$414

Find flight deals from San Antonio to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from San Antonio (SAT) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 31, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$212
(United Airlines)

One-way from

$109
(American Airlines)

Popular in

March

Cheapest in

October

Average price

$378
Provider with most accurate pricing for San Antonio-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Antonio-Knoxville McGhee Tyson flights.
Search Deals
From San Antonio to Knoxville McGhee Tyson
Search Deals
One-way flight from San Antonio to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($48 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from San Antonio to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 31, 2025.
Use the filters below to find and compare flights from San Antonio to Knoxville that are best for you.

Fly from

San Antonio

Fly to

Knoxville

Route

Depart

Return

Price

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 1/17

2:05 pm-8:52 pm

1 stop5h 47m

Knoxville McGhee Tyson

Sun 1/18

6:59 am-10:47 am

1 stop4h 48m

$212

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Tue 2/24

2:10 pm-7:55 pm

1 stop4h 45m

Knoxville McGhee Tyson

Tue 3/3

7:05 am-10:47 am

1 stop4h 42m

$217

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 2/7

7:00 am-1:24 pm

1 stop5h 24m

Knoxville McGhee Tyson

Sat 2/14

9:10 am-1:18 pm

1 stop5h 08m

$217

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Tue 1/27

6:14 am-11:31 am

1 stop4h 17m

Knoxville McGhee Tyson

Thu 1/29

4:41 pm-9:52 pm

1 stop6h 11m

$226

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 1/28

4:40 pm-10:47 pm

1 stop5h 07m

Knoxville McGhee Tyson

Sun 2/1

6:00 am-9:52 am

1 stop4h 52m

$243

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 1/28

5:59 pm-11:44 pm

1 stop4h 45m

Knoxville McGhee Tyson

Sun 2/1

6:45 am-12:24 pm

1 stop6h 39m

$243

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 2/11

6:30 am-1:50 pm

1 stop6h 20m

Knoxville McGhee Tyson

Mon 2/16

6:41 pm-12:35 am

1 stop6h 54m

$262

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 1/10

6:17 pm-11:45 pm

1 stop4h 28m

Knoxville McGhee Tyson

Sat 1/24

11:58 am-3:21 pm

1 stop4h 23m

$267

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 2/12

6:00 am-3:32 pm

1 stop8h 32m

Knoxville McGhee Tyson

Sun 2/15

5:40 am-9:33 am

1 stop4h 53m

$269

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 2/11

9:30 am-5:42 pm

1 stop7h 12m

$109

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/29

Showing 1-10 of 17 results
1
2

Compare providers for flights from San Antonio to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Antonio to Knoxville in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Antonio-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on San Antonio-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from San Antonio-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Antonio-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Antonio-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Antonio to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Antonio with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Antonio to Knoxville

How far ahead should I book a flight from San Antonio to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from San Antonio to Knoxville. Price data was last updated on December 26, 2025.

Booking 73 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Antonio to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Antonio to Knoxville?

Currently, September is the cheapest month in which you can book a flight from San Antonio to Knoxville (average of $80). Flying from San Antonio to Knoxville in January is currently the most expensive (average of $127). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 31, 2025.
Read through reviews of airlines operating flights from San Antonio to Knoxville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,013 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,013 reviews
Delta
7.9
Good
8,013 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,124 reviews
Delta
7.9
Good
8,013 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,074 reviews
Delta
7.9
Good
8,013 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from San Antonio to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Antonio to Knoxville?

    Airlines like United Airlines fly from San Antonio to Knoxville in about 5h 47m. The time it takes to get you to your destination can typically vary by up to . The distance between San Antonio and Knoxville is about 945 mi.

  • What are the cheapest airlines flying from San Antonio to Knoxville round-trip?

    Our cheapest airline available from San Antonio to Knoxville is Delta. Our recent data shows that you can find tickets from as low as $144 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $216 and $259 round-trip. You may be able to fly from San Antonio to Knoxville for 58% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from San Antonio to Knoxville one-way?

    For one-way options, check prices for United Airlines. According to our data, you can fly for as low as $117. Users have also found prices from $124 and $128 on American Airlines and Delta, respectively.

  • Can I find deals for flights from San Antonio to Knoxville that include hotel bookings?

    Yes. In addition to deals on San Antonio to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Antonio to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Antonio to Knoxville.

  • Can I find deals for business class flights from San Antonio to Knoxville?

    Yes. Cheapflights offers flight deals from San Antonio to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Antonio to Knoxville?

    Currently, September is the cheapest month in which you can book a flight from San Antonio to Knoxville (average of $80). Flying from San Antonio to Knoxville in January is currently the most expensive (average of $127). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for San Antonio to Knoxville

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Top 3 airlines flying from San Antonio to Knoxville

Discover the top 3 airlines that operate flights from San Antonio to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$144Average$328FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$216Average$363FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$259Average$374FlexibilityNo cancel feeOn-time69%

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