What are the cheapest airlines flying from San Antonio to Knoxville round-trip?

Our cheapest airline available from San Antonio to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $232 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $236 and $259 round-trip. You may be able to fly from San Antonio to Knoxville for 35% less than the average price by searching for these airlines.

What is the cheapest day to fly from San Antonio to Knoxville?

Travelers seeking maximum savings on their San Antonio to Knoxville flight should consider departing on Tuesday at noon when fares are most often at their lowest. Wednesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

What are the most popular airlines that fly from San Antonio to Knoxville?

The most popular airlines flying from San Antonio to Knoxville are American Airlines, Delta and United Airlines. Something to consider prior to booking your flight.

What is the cheapest day to fly round-trip from San Antonio to Knoxville?

Saturday flights are found to be more expensive to fly from San Antonio to Knoxville. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to Knoxville.

How far in advance should I book a flight from San Antonio to Knoxville?

Users have found that booking a flight from San Antonio to Knoxville at least 58 days early can save you up to 86% on average compared to booking a flight this week. If booking 58 days before your flight isn’t an option for you, users have found flights from San Antonio to Knoxville for as little as $353 when booking for a departure date within the next two weeks. You can also check prices now. Some users have found airline tickets as low as $390 for flights departing within the next 3 days.

What is the cheapest month to fly from San Antonio to Knoxville?

January can be a great time to fly to Knoxville from San Antonio with a flight ticket averaging about $360. Cheapflights users have found deals in the month of January for as cheap as $242. The most expensive prices can be found in the month of March.

Can I find deals for flights from San Antonio to Knoxville that include hotel bookings?

Yes. In addition to deals on San Antonio to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from San Antonio to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Antonio to Knoxville.

Can I find deals for business class flights from San Antonio to Knoxville?

Yes. Cheapflights offers flight deals from San Antonio to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$88+ Cheap Flights from San Antonio to Knoxville

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Cheapflights Tip: The best prices from San Antonio to Knoxville McGhee Tyson are usually found in January or August, booked 73 days in advance, depart on a Wednesday or Tuesday and return on a Friday

Cheap flight deals from San Antonio to Knoxville

Round-trip from	$215 (Kiwi.com)
One-way from	$88 (FlightHub)
Popular in	March
Cheapest in	January
Average price	$306

From San Antonio to Knoxville McGhee Tyson

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One-way flight from San Antonio to Knoxville McGhee Tyson

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Highest demand for flights based on searches. 6% potential increase in price ($26 potential increase over avg. RT price).

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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).

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Average for round-trip flights in August 2025

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Find flight deals from San Antonio to Knoxville

Cheapest flights from San Antonio to Knoxville
Explore the most affordable flight options available from San Antonio to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Fri 10/177:10 pmSAT - TYS

1 stop11h 40mMultiple Airlines

Mon 10/206:00 amTYS - SAT

1 stop13h 15mMultiple Airlines

Deal found 8/13

$215

Wed 10/16:49 pmSAT - TYS

1 stop4h 32mAmerican Airlines

Wed 10/86:43 pmTYS - SAT

1 stop4h 56mAmerican Airlines

Deal found 8/12

$217

Wed 10/158:00 amSAT - TYS

1 stop5h 43mDelta

Tue 11/115:30 amTYS - SAT

1 stop6h 51mDelta

Deal found 8/11

$237

Wed 9/105:00 amSAT - TYS

1 stop7h 13mAmerican Airlines

Wed 9/175:05 amTYS - SAT

1 stop6h 16mAmerican Airlines

Deal found 8/13

$238

Wed 10/158:00 amSAT - TYS

1 stop5h 43mDelta

Mon 11/107:15 pmTYS - SAT

1 stop6h 10mDelta

Deal found 8/11

$243

Sun 10/196:41 amSAT - TYS

1 stop7h 02mDelta

Sat 11/87:45 amTYS - SAT

1 stop7h 50mDelta

Deal found 8/11

$263

Sun 10/196:41 amSAT - TYS

1 stop7h 02mDelta

Mon 11/107:15 pmTYS - SAT

1 stop6h 10mDelta

Deal found 8/11

$269

Thu 10/165:00 pmSAT - TYS

1 stop15h 54mMultiple Airlines

Mon 10/206:00 amTYS - SAT

1 stop10h 55mMultiple Airlines

Deal found 8/12

$271

Thu 10/165:00 pmSAT - TYS

1 stop15h 54mMultiple Airlines

Sun 10/199:50 pmTYS - SAT

1 stop19h 05mMultiple Airlines

Deal found 8/12

$274

Best flights from San Antonio to Knoxville
Discover carefully curated flight deals from San Antonio to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2025.

Fri 10/177:10 pmSAT - TYS

1 stop11h 40mMultiple Airlines

Mon 10/206:00 amTYS - SAT

1 stop13h 15mMultiple Airlines

Deal found 8/13

$215

Sat 9/207:00 amSAT - TYS

1 stop5h 12mAmerican Airlines

Wed 9/245:05 amTYS - SAT

1 stop6h 16mAmerican Airlines

Deal found 8/13

$217

Fri 9/52:25 pmSAT - TYS

1 stop4h 28mUnited Airlines

Tue 9/307:00 amTYS - SAT

2 stops9h 25mUnited Airlines

Deal found 8/14

$238

Wed 10/88:00 amSAT - TYS

1 stop5h 43mDelta

Mon 10/138:10 pmTYS - SAT

1 stop5h 10mDelta

Deal found 8/13

$289

Wed 10/15:00 amSAT - TYS

1 stop7h 13mAmerican Airlines

Wed 10/86:00 amTYS - SAT

1 stop6h 46mAmerican Airlines

Deal found 8/13

$217

Sat 10/186:00 amSAT - TYS

1 stop4h 45mAmerican Airlines

Tue 10/216:00 amTYS - SAT

1 stop4h 19mAmerican Airlines

Deal found 8/13

$217

Fri 9/54:48 pmSAT - TYS

1 stop5h 15mAmerican Airlines

Tue 9/306:00 amTYS - SAT

1 stop4h 30mAmerican Airlines

Deal found 8/14

$233

Thu 10/165:00 pmSAT - TYS

1 stop15h 54mMultiple Airlines

Sun 10/199:50 pmTYS - SAT

1 stop19h 05mMultiple Airlines

Deal found 8/13

$287

Thu 9/185:29 amSAT - TYS

1 stop4h 13mDelta

Mon 9/226:08 pmTYS - SAT

1 stop5h 11mDelta

Deal found 8/13

$304

Wed 9/105:00 amSAT - TYS

1 stop7h 13mAmerican Airlines

Wed 9/175:05 amTYS - SAT

1 stop6h 16mAmerican Airlines

Deal found 8/13

$238

Thu 9/112:54 pmSAT - TYS

1 stop25h 40mMultiple Airlines

Thu 9/1812:08 pmTYS - SAT

1 stop7h 04mMultiple Airlines

Deal found 8/12

$294

Last-minute flights from San Antonio to Knoxville
Discover last-minute flight deals from San Antonio to Knoxville. Data last updated August 14, 2025 and is based on user searches.

Sat 8/166:40 amSAT - TYS

1 stop5h 32mDelta

Tue 8/195:45 amTYS - SAT

1 stop4h 55mDelta

Deal found 8/13

$289

Sat 8/165:10 pmSAT - TYS

1 stop6h 09mAmerican Airlines

Sun 8/175:30 amTYS - SAT

1 stop4h 47mAmerican Airlines

Deal found 8/13

$314

Tue 8/198:00 amSAT - TYS

1 stop4h 08mDelta

Thu 8/214:19 pmTYS - SAT

1 stop7h 09mDelta

Deal found 8/12

$668

Tue 8/197:15 amSAT - TYS

2 stops8h 45mUnited Airlines

Thu 8/2112:00 pmTYS - SAT

1 stop6h 42mUnited Airlines

Deal found 8/12

$673

Wed 9/37:10 amSAT - TYS

1 stop5h 28mUnited Airlines

Sun 9/79:30 amTYS - SAT

1 stop4h 52mUnited Airlines

Deal found 8/12

$319

Wed 9/105:00 amSAT - TYS

1 stop7h 13mAmerican Airlines

Wed 9/175:05 amTYS - SAT

1 stop6h 16mAmerican Airlines

Deal found 8/13

$238

Thu 9/112:54 pmSAT - TYS

1 stop25h 40mMultiple Airlines

Thu 9/1812:08 pmTYS - SAT

1 stop7h 04mMultiple Airlines

Deal found 8/12

$294

Thu 9/185:29 amSAT - TYS

1 stop4h 13mDelta

Mon 9/226:08 pmTYS - SAT

1 stop5h 11mDelta

Deal found 8/13

$304

Thu 9/187:17 pmSAT - TYS

2 stops21h 17mMultiple Airlines

Mon 9/228:30 amTYS - SAT

1 stop13h 22mMultiple Airlines

Deal found 8/14

$339

Sat 9/207:00 amSAT - TYS

1 stop5h 12mAmerican Airlines

Wed 9/245:05 amTYS - SAT

1 stop6h 16mAmerican Airlines

Deal found 8/13

$217

Sat 9/2011:45 amSAT - TYS

2 stops10h 00mUnited Airlines

Wed 9/249:30 amTYS - SAT

1 stop4h 52mUnited Airlines

Deal found 8/13

$313

One-way flights from San Antonio to Knoxville
Search for one-way flight options from San Antonio to Knoxville. Find affordable one-way fares based on user searches. Data last updated August 14, 2025.

Sat 9/133:22 pmSAT - TYS

1 stop23h 56mFrontier

Deal found 8/13

$88

Sat 9/138:37 pmSAT - TYS

3 stops43h 00mMultiple Airlines

Deal found 8/13

$217

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Antonio to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Fri 10/17

7:10 pm-7:50 am

1 stop11h 40m

Knoxville McGhee Tyson

Mon 10/20

6:00 am-6:15 pm

1 stop13h 15m

$215

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 9/20

7:00 am-1:12 pm

1 stop5h 12m

Knoxville McGhee Tyson

Wed 9/24

5:05 am-10:21 am

1 stop6h 16m

$217

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 10/1

5:00 am-1:13 pm

1 stop7h 13m

Knoxville McGhee Tyson

Wed 10/8

6:00 am-11:46 am

1 stop6h 46m

$217

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 10/18

6:00 am-11:45 am

1 stop4h 45m

Knoxville McGhee Tyson

Tue 10/21

6:00 am-9:19 am

1 stop4h 19m

$217

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Fri 9/5

4:48 pm-11:03 pm

1 stop5h 15m

Knoxville McGhee Tyson

Tue 9/30

6:00 am-9:30 am

1 stop4h 30m

$233

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Fri 9/5

2:25 pm-7:53 pm

1 stop4h 28m

Knoxville McGhee Tyson

Tue 9/30

7:00 am-3:25 pm

2 stops9h 25m

$238

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 9/10

5:00 am-1:13 pm

1 stop7h 13m

Knoxville McGhee Tyson

Wed 9/17

5:05 am-10:21 am

1 stop6h 16m

$238

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 10/16

5:00 pm-9:54 am

1 stop15h 54m

Knoxville McGhee Tyson

Sun 10/19

9:50 pm-3:55 pm

1 stop19h 05m

$287

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 10/8

8:00 am-2:43 pm

1 stop5h 43m

Knoxville McGhee Tyson

Mon 10/13

8:10 pm-12:20 am

1 stop5h 10m

$289

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 9/11

2:54 pm-5:34 pm

1 stop25h 40m

Knoxville McGhee Tyson

Thu 9/18

12:08 pm-6:12 pm

1 stop7h 04m

$294

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Showing 1-10 of 13 results

Best time to book a flight from San Antonio to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Antonio with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Antonio to Knoxville

How far ahead should I book a flight from San Antonio to Knoxville?

Booking 73 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Antonio to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Antonio to Knoxville?

Currently, January is the cheapest month in which you can book a flight from San Antonio to Knoxville (average of $294). Flying from San Antonio to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAT to TYS?

A simple way to save on the total cost of your ticket is to fly from San Antonio to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 26% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Knoxville

Read through reviews of airlines operating flights from San Antonio to Knoxville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,980 reviews

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,916 reviews

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from San Antonio to Knoxville round-trip?
Our cheapest airline available from San Antonio to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $232 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $236 and $259 round-trip. You may be able to fly from San Antonio to Knoxville for 35% less than the average price by searching for these airlines.
Can I find deals for flights from San Antonio to Knoxville that include hotel bookings?
Yes. In addition to deals on San Antonio to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from San Antonio to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Antonio to Knoxville.
Can I find deals for business class flights from San Antonio to Knoxville?
Yes. Cheapflights offers flight deals from San Antonio to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from San Antonio to Knoxville?
Currently, January is the cheapest month in which you can book a flight from San Antonio to Knoxville (average of $294). Flying from San Antonio to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Morristown

Cherokee

Corbin

Alcoa

Oak Ridge

Murphy

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Top 3 airlines flying from San Antonio to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$232	Average$364	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$236	Average$342	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$259	Average$408	FlexibilityNo cancel fee	On-time69%

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$88+ Cheap flights from San Antonio to Knoxville (SAT - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/13. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from San Antonio to Knoxville with Cheapflights

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Cheapflights Tip: The best prices from San Antonio to Knoxville McGhee Tyson are usually found in January or August, booked 73 days in advance, depart on a Wednesday or Tuesday and return on a Friday

Cheap flight deals from San Antonio to Knoxville

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from San Antonio to Knoxville

Cheapest flights from San Antonio to KnoxvilleExplore the most affordable flight options available from San Antonio to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Explore the most affordable flight options available from San Antonio to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Antonio to Knoxville that are best for you.

Best time to book a flight from San Antonio to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Antonio with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from San Antonio to Knoxville

How far ahead should I book a flight from San Antonio to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from San Antonio to Knoxville. Price data was last updated on August 8, 2025.

What is the cheapest month to book a flight from San Antonio to Knoxville?

What is the cheapest time of day to fly from SAT to TYS?

Find hourly flight availability from San Antonio to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

Reviews of airlines servicing Knoxville

Read through reviews of airlines operating flights from San Antonio to Knoxville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from San Antonio to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from San Antonio to Knoxville round-trip?

Can I find deals for flights from San Antonio to Knoxville that include hotel bookings?

How can I find direct flights from San Antonio to Knoxville?

Can I find deals for business class flights from San Antonio to Knoxville?

What is the cheapest month to book a flight from San Antonio to Knoxville?

Traveling to a place near Knoxville?

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Alternative routes for San Antonio to Knoxville

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Top 3 airlines flying from San Antonio to Knoxville

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Cheapest flights from San Antonio to Knoxville
Explore the most affordable flight options available from San Antonio to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.