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$37+ Cheap flights from Mississippi to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — TYS
Dez 2 — Dez 91
Di 12/2
Di 12/9
1 adult, Economy
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Cheap flight deals from Mississippi to Knoxville

Keep the following information in mind while searching for Mississippi to Knoxville flight deals. Data was last updated November 2, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$80
(FlightHub)

One-way from

$37
(Kiwi.com)

Popular in

November

Cheapest in

July

Average price

$766
Provider with most accurate pricing for Jackson-Evers Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Knoxville McGhee Tyson flights.
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From Mississippi to Knoxville McGhee Tyson
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One-way flight from Mississippi to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 26% potential increase in price ($159 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($30 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Mississippi to Knoxville

Cheapest flights from Mississippi to Knoxville
Explore the most affordable flight options available from Mississippi to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2025.

This FlightHub deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 11/201:41 pmMEM - TYS
Nonstop1h 22mAllegiant Air
Fr 11/2812:45 pmTYS - MEM
Nonstop1h 27mAllegiant Air
Deal found 11/1$80
This FlightHub deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 11/282:02 pmMEM - TYS
Nonstop1h 22mAllegiant Air
Mo 12/112:50 pmTYS - MEM
Nonstop1h 27mAllegiant Air
Deal found 11/1$85
This FlightHub deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 11/201:41 pmMEM - TYS
Nonstop1h 22mAllegiant Air
So 11/2312:24 pmTYS - MEM
Nonstop1h 27mAllegiant Air
Deal found 11/1$87
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
So 11/162:30 pmMEM - TYS
Nonstop1h 19mAllegiant Air
Do 11/2012:24 pmTYS - MEM
Nonstop1h 27mAllegiant Air
Deal found 11/1$91
This FlightHub deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 11/132:30 pmMEM - TYS
Nonstop1h 19mAllegiant Air
So 11/161:16 pmTYS - MEM
Nonstop1h 24mAllegiant Air
Deal found 11/2$100
This FlightHub deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
So 11/92:30 pmMEM - TYS
Nonstop1h 19mAllegiant Air
So 11/161:16 pmTYS - MEM
Nonstop1h 24mAllegiant Air
Deal found 11/2$113
This FlightHub deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 11/62:30 pmMEM - TYS
Nonstop1h 19mAllegiant Air
So 11/91:16 pmTYS - MEM
Nonstop1h 24mAllegiant Air
Deal found 11/2$124
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 12/12:07 pmMEM - TYS
Nonstop1h 22mMultiple Airlines
Mo 12/85:34 pmTYS - MEM
1 stop26h 13mMultiple Airlines
Deal found 11/2$151
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 11/148:17 pmMEM - TYS
1 stop10h 59mAllegiant Air
So 11/161:16 pmTYS - MEM
Nonstop1h 24mAllegiant Air
Deal found 11/2$170
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 12/56:01 pmGPT - TYS
1 stop4h 27mDelta
So 12/75:40 amTYS - GPT
1 stop5h 10mDelta
Deal found 11/2$278
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 11/156:00 amBTR - TYS
1 stop5h 23mDelta
Mi 11/192:41 pmTYS - BTR
1 stop6h 16mDelta
Deal found 10/31$279
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 11/152:15 pmBTR - TYS
2 stops8h 36mAmerican Airlines
Mi 11/195:10 amTYS - BTR
1 stop5h 43mAmerican Airlines
Deal found 10/31$284

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
Use the filters below to find and compare flights from Mississippi to Knoxville that are best for you.

Fly from

Mississippi

Fly to

Knoxville

Route

Depart

Return

Price

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Mo 12/1

2:07 pm-4:29 pm

Nonstop1h 22m

Knoxville McGhee Tyson

Mo 12/8

5:34 pm-6:47 pm

1 stop26h 13m

$151

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Do 11/13

3:07 pm-4:29 pm

1 stop24h 22m

Knoxville McGhee Tyson

So 11/16

1:16 pm-1:40 pm

Nonstop1h 24m

$176

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Di 11/25

7:11 pm-12:16 pm

2 stops16h 05m

Knoxville McGhee Tyson

Fr 11/28

12:45 pm-1:12 pm

Nonstop1h 27m

$211

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Fr 11/28

2:02 pm-4:24 pm

Nonstop1h 22m

Knoxville McGhee Tyson

Mo 12/1

11:29 am-9:02 am

1 stop22h 33m

$217

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Do 11/13

7:11 pm-10:56 pm

3 stops26h 45m

Knoxville McGhee Tyson

So 11/16

1:16 pm-1:40 pm

Nonstop1h 24m

$245

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Mi 2/25

6:00 am-11:07 am

1 stop4h 07m

Knoxville McGhee Tyson

So 3/1

10:05 am-2:56 pm

1 stop5h 51m

$249

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Do 1/22

8:35 pm-3:19 pm

1 stop17h 44m

Knoxville McGhee Tyson

Do 1/29

1:39 pm-3:14 pm

2 stops50h 35m

$249

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Di 12/9

1:22 pm-12:03 pm

1 stop21h 41m

Knoxville McGhee Tyson

Fr 12/12

6:30 am-2:26 pm

1 stop8h 56m

$255

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Do 12/11

5:14 pm-8:33 am

1 stop14h 19m

Knoxville McGhee Tyson

So 12/14

5:23 pm-2:26 pm

2 stops22h 03m

$266

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Fr 11/21

9:22 pm-7:10 pm

2 stops20h 48m

Knoxville McGhee Tyson

So 11/23

12:24 pm-12:51 pm

Nonstop1h 27m

$271

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/1

Showing 1-10 of 58 results
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Best time to book a flight from Mississippi to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Knoxville

What is the cheapest month to book a flight from Mississippi to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $149). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS to TYS?

Find hourly flight availability from Mississippi to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 2, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 42% on flights from Mississippi to Knoxville by exploring options for tickets in the afternoon.

How much does it cost to fly round-trip from Mississippi to Knoxville?

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mississippi?

    For a flight from Mississippi to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Mississippi to Knoxville?

    Airlines like Allegiant Air, Delta, and American Airlines fly from Mississippi to Knoxville in about 4h 07m. The time it takes to get you to your destination can typically vary by up to 20h 15m. The distance from Mississippi to Knoxville is about 551 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Mississippi to Knoxville one-way?

    $37 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $199 and $199, respectively.

  • What are the most popular routes from Mississippi to Knoxville?

    When deciding which route to take from Mississippi to Knoxville consider Memphis - Knoxville McGhee Tyson, Baton Rouge Ryan - Knoxville McGhee Tyson or Jackson-Evers Intl - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from Mississippi to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mississippi to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Knoxville.

  • Can I find deals for business class flights from Mississippi to Knoxville?

    Yes. Cheapflights offers flight deals from Mississippi to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $149). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mississippi to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Mississippi to Knoxville

Discover the top 2 airlines that operate flights from Mississippi to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$164Average$394FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$405FlexibilityNo cancel feeOn-time71%

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