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Knoxville

$44+ Cheap flights from Mississippi to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — TYS
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
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Cheap flight deals from Mississippi to Knoxville

Keep the following information in mind while searching for Mississippi to Knoxville flight deals. Data was last updated July 31, 2025.

Round-trip from

$80
(Booking.com)

Popular in

August

Cheapest in

January

Average price

$630
From Mississippi to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($92 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($32 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Mississippi to Knoxville

Cheapest flights from Mississippi to Knoxville
Explore the most affordable flight options available from Mississippi to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This Booking.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/22:30 pmMEM - TYS
Nonstop1h 19mAllegiant Air
Thu 11/61:16 pmTYS - MEM
Nonstop1h 24mAllegiant Air
Deal found 7/30$80
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/247:00 amMEM - TYS
1 stop15h 39mMultiple Airlines
Sun 10/265:34 pmTYS - MEM
Nonstop1h 24mMultiple Airlines
Deal found 7/29$143
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2311:30 amJAN - TYS
1 stop4h 33mDelta
Sat 9/278:35 amTYS - JAN
1 stop4h 03mDelta
Deal found 7/31$229
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/82:50 pmMEM - TYS
1 stop6h 55mUnited Airlines
Sat 9/1310:54 amTYS - MEM
1 stop4h 56mUnited Airlines
Deal found 7/30$229
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/156:00 amJAN - TYS
1 stop6h 03mAmerican Airlines
Tue 8/193:41 pmTYS - JAN
1 stop5h 38mAmerican Airlines
Deal found 7/31$239
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2710:20 amBTR - TYS
1 stop5h 59mDelta
Wed 9/38:35 amTYS - BTR
1 stop6h 02mDelta
Deal found 7/29$249
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/136:20 amGPT - TYS
1 stop5h 43mAmerican Airlines
Wed 8/2012:03 pmTYS - GPT
1 stop5h 14mAmerican Airlines
Deal found 7/31$254
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/34:31 pmBTR - TYS
1 stop6h 50mAmerican Airlines
Sat 9/68:23 amTYS - BTR
2 stops8h 38mAmerican Airlines
Deal found 7/30$254
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/229:57 amMEM - TYS
1 stop5h 58mAmerican Airlines
Wed 8/275:26 pmTYS - MEM
1 stop6h 34mAmerican Airlines
Deal found 7/29$257
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1210:13 amGPT - TYS
1 stop4h 21mDelta
Wed 8/136:14 pmTYS - GPT
1 stop4h 24mDelta
Deal found 7/30$304
This Trip.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/235:05 pmJAN - TYS
1 stop5h 39mUnited Airlines
Sat 9/277:15 amTYS - JAN
1 stop7h 14mUnited Airlines
Deal found 7/30$358
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/37:10 amBTR - TYS
1 stop7h 08mUnited Airlines
Sat 8/95:46 pmTYS - BTR
2 stops16h 13mUnited Airlines
Deal found 7/29$513

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Mississippi to Knoxville that are best for you.

Fly from

Mississippi

Fly to

Knoxville

Route

Depart

Return

Price

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Sun 11/2

2:30 pm-4:49 pm

Nonstop1h 19m

Knoxville McGhee Tyson

Thu 11/6

1:16 pm-1:40 pm

Nonstop1h 24m

$80

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Fri 10/24

7:00 am-11:39 pm

1 stop15h 39m

Knoxville McGhee Tyson

Sun 10/26

5:34 pm-5:58 pm

Nonstop1h 24m

$143

JacksonKnoxville

JAN - TYS

JANTYS

Jackson-Evers Intl

Tue 9/23

11:30 am-5:03 pm

1 stop4h 33m

Knoxville McGhee Tyson

Sat 9/27

8:35 am-11:38 am

1 stop4h 03m

$229

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Mon 9/8

2:50 pm-10:45 pm

1 stop6h 55m

Knoxville McGhee Tyson

Sat 9/13

10:54 am-2:50 pm

1 stop4h 56m

$229

JacksonKnoxville

JAN - TYS

JANTYS

Jackson-Evers Intl

Fri 8/15

6:00 am-1:03 pm

1 stop6h 03m

Knoxville McGhee Tyson

Tue 8/19

3:41 pm-8:19 pm

1 stop5h 38m

$239

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Wed 8/27

10:20 am-5:19 pm

1 stop5h 59m

Knoxville McGhee Tyson

Wed 9/3

8:35 am-1:37 pm

1 stop6h 02m

$249

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Wed 8/13

6:20 am-1:03 pm

1 stop5h 43m

Knoxville McGhee Tyson

Wed 8/20

12:03 pm-4:17 pm

1 stop5h 14m

$254

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Wed 9/3

4:31 pm-12:21 am

1 stop6h 50m

Knoxville McGhee Tyson

Sat 9/6

8:23 am-4:01 pm

2 stops8h 38m

$254

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Fri 8/22

9:57 am-4:55 pm

1 stop5h 58m

Knoxville McGhee Tyson

Wed 8/27

5:26 pm-11:00 pm

1 stop6h 34m

$257

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Tue 8/12

10:13 am-3:34 pm

1 stop4h 21m

Knoxville McGhee Tyson

Wed 8/13

6:14 pm-9:38 pm

1 stop4h 24m

$304

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Showing 1-10 of 23 results
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Best time to book a flight from Mississippi to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Knoxville

What is the cheapest month to book a flight from Mississippi to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $294). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS to TYS?

Find hourly flight availability from Mississippi to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to Knoxville as you normally would.

How much does it cost to fly round-trip from Mississippi to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 31, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Mississippi to Knoxville to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,900 reviews
Delta
8.0
Very good
7,981 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
702 reviews
Delta
8.0
Very good
7,981 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mississippi?

    For a flight from Mississippi to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from Mississippi to Knoxville one-way?

    $102 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on United Airlines and Delta, with prices starting from $135 and $197, respectively.

  • What are the most popular routes from Mississippi to Knoxville?

    When deciding which route to take from Mississippi to Knoxville consider Memphis - Knoxville McGhee Tyson, Gulfport Biloxi Regional - Knoxville McGhee Tyson or Baton Rouge Ryan - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from Mississippi to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mississippi to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Knoxville.

  • Can I find deals for business class flights from Mississippi to Knoxville?

    Yes. Cheapflights offers flight deals from Mississippi to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $294). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Mississippi to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Mississippi to Knoxville

Discover the top 2 airlines that operate flights from Mississippi to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$384FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$238Average$420FlexibilityNo cancel feeOn-time71%

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