HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$114+ Cheap flights from Mississippi to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/29. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — TYS
Mar 22 — Mar 291
Sun 3/22
Sun 3/29
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Mississippi to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Mississippi to Knoxville

Cheapest flights from Mississippi to Knoxville
Explore the most affordable flight options available from Mississippi to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/28:54 pm
MEM
-
TYS
1 stop25h 26m
Multiple Airlines
Mon 4/62:06 pm
TYS
-
MEM
1 stop21h 09m
Multiple Airlines
Deal found 2/18$235
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/28:54 pm
MEM
-
TYS
1 stop25h 26m
Allegiant Air
Thu 4/99:36 pm
TYS
-
MEM
1 stop10h 39m
Allegiant Air
Deal found 2/16$246
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:33 pm
MEM
-
TYS
1 stop24h 58m
Multiple Airlines
Mon 6/110:03 pm
TYS
-
MEM
1 stop13h 04m
Multiple Airlines
Deal found 2/16$252
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2811:14 am
MEM
-
TYS
1 stop8h 31m
Multiple Airlines
Mon 3/303:29 pm
TYS
-
MEM
1 stop19h 46m
Multiple Airlines
Deal found 2/19$253
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/28:54 pm
MEM
-
TYS
1 stop25h 26m
Allegiant Air
Sun 4/52:16 pm
TYS
-
MEM
1 stop6h 51m
Allegiant Air
Deal found 2/18$258
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/22:47 pm
MEM
-
TYS
1 stop23h 41m
Multiple Airlines
Sun 4/56:44 pm
TYS
-
MEM
1 stop14h 18m
Multiple Airlines
Deal found 2/18$259
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/97:05 pm
BTR
-
TYS
1 stop3h 52m
Delta
Tue 4/145:40 am
TYS
-
BTR
1 stop5h 06m
Delta
Deal found 2/18$269
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/273:12 pm
MEM
-
TYS
1 stop15h 58m
Allegiant Air
Sun 3/296:55 pm
TYS
-
MEM
1 stop19h 34m
Allegiant Air
Deal found 2/18$273
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/293:00 pm
MEM
-
TYS
1 stop16h 08m
Multiple Airlines
Mon 3/303:29 pm
TYS
-
MEM
1 stop19h 46m
Multiple Airlines
Deal found 2/16$278
This Southwest deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/171:10 pm
MEM
-
TYS
1 stop7h 00m
Southwest
Wed 3/186:35 am
TYS
-
MEM
1 stop3h 15m
Southwest
Deal found 2/16$279
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:03 am
MEM
-
TYS
1 stop7h 56m
Allegiant Air
Sat 2/281:52 pm
TYS
-
MEM
1 stop25h 09m
Allegiant Air
Deal found 2/19$281
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:00 am
BTR
-
TYS
1 stop7h 41m
American Airlines
Thu 11/265:10 am
TYS
-
BTR
1 stop5h 42m
American Airlines
Deal found 2/16$293

Find flight deals from Mississippi to Knoxville

Keep the following information in mind while searching for Mississippi to Knoxville flight deals. Data was last updated February 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$235
(Kiwi.com)

One-way from

$114
(Kiwi.com)

Popular in

November

Cheapest in

July

Average price

$693
Provider with most accurate pricing for Jackson-Evers Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Knoxville McGhee Tyson flights.
Search Deals
From Mississippi to Knoxville McGhee Tyson
Search Deals
One-way flight from Mississippi to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 28% potential increase in price ($172 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2026.
Use the filters below to find and compare flights from Mississippi to Knoxville that are best for you.

Fly from

Mississippi

Fly to

Knoxville

Route

Depart

Return

Price

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 4/2

8:54 pm-11:20 pm

1 stop25h 26m

Knoxville McGhee Tyson

Mon 4/6

2:06 pm-10:15 am

1 stop21h 09m

$235

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 4/2

8:54 pm-11:20 pm

1 stop25h 26m

Knoxville McGhee Tyson

Thu 4/9

9:36 pm-7:15 am

1 stop10h 39m

$246

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Sat 3/28

11:14 am-8:45 pm

1 stop8h 31m

Knoxville McGhee Tyson

Mon 3/30

3:29 pm-10:15 am

1 stop19h 46m

$253

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Sat 4/11

1:36 pm-8:20 pm

1 stop5h 44m

Knoxville McGhee Tyson

Mon 4/13

5:40 am-9:46 am

1 stop5h 06m

$269

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Tue 3/17

4:28 pm-11:20 pm

1 stop5h 52m

Knoxville McGhee Tyson

Tue 3/24

4:29 pm-10:39 pm

1 stop7h 10m

$269

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Thu 4/9

7:05 pm-11:57 pm

1 stop3h 52m

Knoxville McGhee Tyson

Wed 4/15

4:38 pm-9:56 pm

1 stop6h 18m

$269

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Fri 3/27

3:12 pm-8:10 am

1 stop15h 58m

Knoxville McGhee Tyson

Sun 3/29

6:55 pm-1:29 pm

1 stop19h 34m

$273

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Tue 3/17

1:10 pm-9:10 pm

1 stop7h 00m

Knoxville McGhee Tyson

Wed 3/18

6:35 am-8:50 am

1 stop3h 15m

$279

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Fri 2/27

5:09 pm-1:02 pm

1 stop18h 53m

Knoxville McGhee Tyson

Sun 3/1

7:00 am-2:01 pm

1 stop8h 01m

$282

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Mon 3/9

4:58 pm-10:10 am

1 stop16h 12m

Knoxville McGhee Tyson

Wed 3/11

1:41 pm-6:20 pm

2 stops29h 39m

$287

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/17

Showing 1-10 of 49 results
1
2
3
...
5

Best time to book a flight from Mississippi to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Knoxville

What is the cheapest month to book a flight from Mississippi to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $149). Flying from Mississippi to Knoxville in February is currently the most expensive (average of $325). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mississippi?

    For a flight from Mississippi to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Mississippi to Knoxville?

    Airlines like Allegiant Air, Delta, and American Airlines fly from Mississippi to Knoxville in about 5h 44m. The time it takes to get you to your destination can typically vary by up to 19h 42m. The distance from Mississippi to Knoxville is about 551 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Mississippi to Knoxville?

    When deciding which route to take from Mississippi to Knoxville consider Memphis - Knoxville McGhee Tyson, Baton Rouge Ryan - Knoxville McGhee Tyson or Jackson-Evers Intl - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from Mississippi to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mississippi to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Knoxville.

  • Can I find deals for business class flights from Mississippi to Knoxville?

    Yes. Cheapflights offers flight deals from Mississippi to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $149). Flying from Mississippi to Knoxville in February is currently the most expensive (average of $325). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mississippi to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Newark to Nashville flights
John F Kennedy Intl to Nashville flights
LaGuardia to Nashville flights
Philadelphia to Nashville flights
Boston to Nashville flights
Los Angeles to Nashville flights
Reagan-National to Nashville flights
O'Hare Intl to Nashville flights
Dallas/Fort Worth to Nashville flights
Minneapolis to Nashville flights
Dulles Intl to Nashville flights
Denver to Nashville flights
Baltimore to Nashville flights
Raleigh to Nashville flights
San Francisco to Nashville flights
Hobby to Nashville flights
Detroit to Nashville flights
LaGuardia to Knoxville flights
Seattle to Nashville flights
Sky Harbor Intl to Nashville flights
Ontario to Nashville flights
Charlotte to Nashville flights
Austin to Nashville flights
Orlando to Nashville flights
Denver to Knoxville flights
George Bush Intcntl to Nashville flights
Hartford to Nashville flights
Cleveland to Nashville flights
John F Kennedy Intl to Knoxville flights
Fort Lauderdale to Nashville flights
Midway to Nashville flights
Providence to Nashville flights
San Diego to Nashville flights
Santa Ana to Nashville flights
Portland to Nashville flights
O'Hare Intl to Knoxville flights
Atlanta to Memphis flights
Burbank to Nashville flights
Tampa to Nashville flights
Richmond to Nashville flights
Sacramento to Nashville flights
LaGuardia to Memphis flights
Kansas City to Nashville flights
Miami to Nashville flights
Love Field to Nashville flights
Dallas/Fort Worth to Memphis flights
John F Kennedy Intl to Memphis flights
Los Angeles to Memphis flights
Dulles Intl to Memphis flights
Dulles Intl to Knoxville flights

Top 2 airlines flying from Mississippi to Knoxville

Discover the top 2 airlines that operate flights from Mississippi to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$153Average$445FlexibilityNo cancel feeOn-time71%
DeltaCheapest$164Average$393FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2026 Cheapflights