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$49+ Cheap flights from Mississippi to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — TYS
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Mississippi to Knoxville

Keep the following information in mind while searching for Mississippi to Knoxville flight deals. Data was last updated September 15, 2025.

Round-trip from

$88
(Kiwi.com)

One-way from

$49
(Kiwi.com)

Popular in

February

Cheapest in

July

Average price

$398
From Mississippi to Knoxville McGhee Tyson
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One-way flight from Mississippi to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 13% potential increase in price ($65 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($30 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Mississippi to Knoxville

Cheapest flights from Mississippi to Knoxville
Explore the most affordable flight options available from Mississippi to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:58 pmMEM - TYS
Nonstop1h 19mAllegiant Air
Sun 10/55:44 pmTYS - MEM
Nonstop1h 24mAllegiant Air
Deal found 9/13$88
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/258:49 pmMEM - TYS
Nonstop1h 19mAllegiant Air
Sun 9/287:35 pmTYS - MEM
Nonstop1h 24mAllegiant Air
Deal found 9/13$89
This FlightHub deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:58 pmMEM - TYS
Nonstop1h 19mAllegiant Air
Thu 10/95:44 pmTYS - MEM
Nonstop1h 24mAllegiant Air
Deal found 9/15$90
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/126:58 pmMEM - TYS
Nonstop1h 19mAllegiant Air
Sun 10/195:34 pmTYS - MEM
Nonstop1h 24mAllegiant Air
Deal found 9/14$98
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/282:02 pmMEM - TYS
Nonstop1h 22mAllegiant Air
Mon 12/112:50 pmTYS - MEM
Nonstop1h 27mAllegiant Air
Deal found 9/14$102
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/188:49 pmMEM - TYS
Nonstop1h 19mAllegiant Air
Thu 9/257:35 pmTYS - MEM
Nonstop1h 24mAllegiant Air
Deal found 9/13$113
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/231:41 pmMEM - TYS
Nonstop1h 22mAllegiant Air
Mon 12/112:50 pmTYS - MEM
Nonstop1h 27mAllegiant Air
Deal found 9/14$114
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/188:49 pmMEM - TYS
Nonstop1h 19mAllegiant Air
Sun 9/217:35 pmTYS - MEM
Nonstop1h 24mAllegiant Air
Deal found 9/13$116
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/231:41 pmMEM - TYS
Nonstop1h 22mAllegiant Air
Fri 11/2812:45 pmTYS - MEM
Nonstop1h 27mAllegiant Air
Deal found 9/14$123
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/132:30 pmMEM - TYS
Nonstop1h 19mAllegiant Air
Sun 11/161:16 pmTYS - MEM
Nonstop1h 24mAllegiant Air
Deal found 9/14$131
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/162:30 pmMEM - TYS
Nonstop1h 19mAllegiant Air
Wed 11/196:04 pmTYS - MEM
1 stop26h 44mAllegiant Air
Deal found 9/14$150
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:32 pmGPT - TYS
1 stop4h 31mAmerican Airlines
Sun 9/288:36 pmTYS - GPT
1 stop4h 29mAmerican Airlines
Deal found 9/14$254

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Mississippi to Knoxville that are best for you.

Fly from

Mississippi

Fly to

Knoxville

Route

Depart

Return

Price

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 10/2

6:58 pm-9:17 pm

Nonstop1h 19m

Knoxville McGhee Tyson

Sun 10/5

5:44 pm-6:08 pm

Nonstop1h 24m

$88

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 9/25

8:49 pm-11:08 pm

Nonstop1h 19m

Knoxville McGhee Tyson

Sun 9/28

7:35 pm-7:59 pm

Nonstop1h 24m

$89

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Sun 11/23

1:41 pm-4:03 pm

Nonstop1h 22m

Knoxville McGhee Tyson

Fri 11/28

12:45 pm-1:12 pm

Nonstop1h 27m

$123

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Mon 12/1

2:07 pm-4:29 pm

Nonstop1h 22m

Knoxville McGhee Tyson

Thu 12/4

6:30 am-7:05 pm

1 stop13h 35m

$140

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Fri 10/31

8:09 pm-8:15 am

1 stop11h 06m

Knoxville McGhee Tyson

Sun 11/2

1:16 pm-1:40 pm

Nonstop1h 24m

$176

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Mon 11/24

4:19 pm-10:52 pm

1 stop5h 33m

Knoxville McGhee Tyson

Mon 12/1

12:50 pm-1:17 pm

Nonstop1h 27m

$210

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Fri 11/14

8:17 pm-8:16 am

1 stop10h 59m

Knoxville McGhee Tyson

Sun 11/16

1:16 pm-1:40 pm

Nonstop1h 24m

$211

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 10/23

6:48 pm-9:07 pm

Nonstop1h 19m

Knoxville McGhee Tyson

Mon 10/27

11:00 am-7:45 pm

2 stops33h 45m

$214

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 10/9

6:58 pm-9:17 pm

Nonstop1h 19m

Knoxville McGhee Tyson

Sun 10/12

5:44 pm-6:08 pm

Nonstop1h 24m

$229

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Wed 2/18

3:35 pm-9:43 pm

1 stop5h 08m

Knoxville McGhee Tyson

Sat 2/21

7:20 pm-10:52 pm

1 stop4h 32m

$247

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 42 results
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Best time to book a flight from Mississippi to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Knoxville

What is the cheapest month to book a flight from Mississippi to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $295). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS to TYS?

Find hourly flight availability from Mississippi to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to Knoxville as you normally would.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mississippi?

    For a flight from Mississippi to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Mississippi to Knoxville?

    Airlines like Allegiant Air and American Airlines fly from Mississippi to Knoxville in about 1h 19m. The time it takes to get you to your destination can typically vary by up to 3h 12m. The distance from Mississippi to Knoxville is about 341 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Mississippi to Knoxville?

    When deciding which route to take from Mississippi to Knoxville consider Gulfport Biloxi Regional - Knoxville McGhee Tyson, Memphis - Knoxville McGhee Tyson or Baton Rouge Ryan - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from Mississippi to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mississippi to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Knoxville.

  • Can I find deals for business class flights from Mississippi to Knoxville?

    Yes. Cheapflights offers flight deals from Mississippi to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $295). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Mississippi to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Mississippi to Knoxville

Discover the top 2 airlines that operate flights from Mississippi to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$228Average$392FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$416FlexibilityNo cancel feeOn-time71%

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