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Knoxville

$131+ Cheap flights from Mississippi to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/8. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — TYS
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Mississippi to Knoxville

Cheapest flights from Mississippi to Knoxville
Explore the most affordable flight options available from Mississippi to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:13 pmMEM - TYS
1 stop19h 39mMultiple Airlines
Wed 12/3112:01 pmTYS - MEM
2 stops28h 07mMultiple Airlines
Deal found 12/17$329
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:07 amBTR - TYS
1 stop3h 24mDelta
Sun 1/46:59 pmTYS - BTR
1 stop3h 54mDelta
Deal found 12/16$369
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:40 pmMEM - TYS
1 stop19h 21mAllegiant Air
Fri 1/96:00 amTYS - MEM
1 stop9h 50mAllegiant Air
Deal found 12/17$372
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:05 amMEM - TYS
1 stop6h 16mAmerican Airlines
Sun 1/45:00 amTYS - MEM
1 stop4h 47mAmerican Airlines
Deal found 12/15$377
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:40 pmMEM - TYS
1 stop19h 21mAllegiant Air
Mon 1/126:00 amTYS - MEM
1 stop9h 50mAllegiant Air
Deal found 12/17$378
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:40 pmMEM - TYS
1 stop19h 21mAllegiant Air
Sun 1/118:30 amTYS - MEM
1 stop12h 15mAllegiant Air
Deal found 12/17$386
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:40 pmMEM - TYS
1 stop19h 21mAllegiant Air
Sat 1/105:59 pmTYS - MEM
1 stop16h 51mAllegiant Air
Deal found 12/17$387
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:40 pmMEM - TYS
1 stop19h 21mAllegiant Air
Thu 1/88:30 amTYS - MEM
1 stop12h 15mAllegiant Air
Deal found 12/17$398
This Kiwi.com deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/188:40 pmMEM - TYS
1 stop19h 21mAllegiant Air
Wed 12/245:31 pmTYS - MEM
1 stop26h 36mAllegiant Air
Deal found 12/18$413
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:40 pmMEM - TYS
1 stop19h 21mMultiple Airlines
Tue 1/67:22 pmTYS - MEM
2 stops25h 00mMultiple Airlines
Deal found 12/17$427
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2512:01 pmJAN - TYS
1 stop6h 49mUnited Airlines
Tue 12/307:00 amTYS - JAN
1 stop5h 26mUnited Airlines
Deal found 12/16$432
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:08 pmMEM - TYS
1 stop19h 44mMultiple Airlines
Mon 1/511:22 amTYS - MEM
2 stops33h 00mMultiple Airlines
Deal found 12/17$433

Find flight deals from Mississippi to Knoxville

Keep the following information in mind while searching for Mississippi to Knoxville flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$224
(Kiwi.com)

One-way from

$131
(Kiwi.com)

Popular in

November

Cheapest in

July

Average price

$546
Provider with most accurate pricing for Jackson-Evers Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Knoxville McGhee Tyson flights.
Search Deals
From Mississippi to Knoxville McGhee Tyson
Search Deals
One-way flight from Mississippi to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 29% potential increase in price ($182 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($30 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Mississippi to Knoxville that are best for you.

Fly from

Mississippi

Fly to

Knoxville

Route

Depart

Return

Price

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Fri 1/9

3:40 pm-10:28 pm

1 stop5h 48m

Knoxville McGhee Tyson

Mon 1/12

6:00 am-2:50 pm

1 stop9h 50m

$221

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Fri 1/30

3:40 pm-10:28 pm

1 stop5h 48m

Knoxville McGhee Tyson

Fri 2/6

12:55 pm-10:49 am

1 stop22h 54m

$241

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Wed 1/7

8:17 pm-1:10 pm

1 stop15h 53m

Knoxville McGhee Tyson

Sun 1/11

8:30 am-7:45 pm

1 stop12h 15m

$242

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 1/22

11:44 am-12:05 pm

2 stops23h 21m

Knoxville McGhee Tyson

Sun 1/25

8:30 am-7:45 pm

1 stop12h 15m

$246

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Wed 1/7

1:57 pm-7:50 pm

1 stop4h 53m

Knoxville McGhee Tyson

Sat 1/10

6:59 am-1:22 pm

1 stop7h 23m

$249

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Wed 2/4

6:05 am-11:08 am

1 stop4h 03m

Knoxville McGhee Tyson

Sat 2/7

11:58 am-3:09 pm

1 stop4h 11m

$249

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 1/22

8:35 pm-3:19 pm

1 stop17h 44m

Knoxville McGhee Tyson

Sun 1/25

8:30 am-7:45 pm

1 stop12h 15m

$249

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Sat 2/14

4:29 pm-10:00 pm

1 stop4h 31m

Knoxville McGhee Tyson

Thu 2/19

4:30 pm-10:36 pm

1 stop7h 06m

$269

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Tue 2/17

10:34 am-3:15 pm

1 stop3h 41m

Knoxville McGhee Tyson

Sat 2/21

12:00 pm-3:54 pm

1 stop4h 54m

$269

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Wed 2/11

6:18 am-11:08 am

1 stop3h 50m

Knoxville McGhee Tyson

Tue 2/17

5:30 am-9:52 am

1 stop5h 22m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 44 results
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Best time to book a flight from Mississippi to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Knoxville

What is the cheapest month to book a flight from Mississippi to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $149). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS to TYS?

Find hourly flight availability from Mississippi to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 42% on flights from Mississippi to Knoxville by exploring options for tickets in the afternoon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mississippi?

    For a flight from Mississippi to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Mississippi to Knoxville?

    Airlines like Allegiant Air, United Airlines, and Delta fly from Mississippi to Knoxville in about 4h 03m. The time it takes to get you to your destination can typically vary by up to 1h 45m. The distance from Mississippi to Knoxville is about 474 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Mississippi to Knoxville?

    When deciding which route to take from Mississippi to Knoxville consider Memphis - Knoxville McGhee Tyson, Baton Rouge Ryan - Knoxville McGhee Tyson or Gulfport Biloxi Regional - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from Mississippi to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mississippi to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Knoxville.

  • Can I find deals for business class flights from Mississippi to Knoxville?

    Yes. Cheapflights offers flight deals from Mississippi to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $149). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mississippi to Knoxville

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Top 2 airlines flying from Mississippi to Knoxville

Discover the top 2 airlines that operate flights from Mississippi to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$164Average$392FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$405FlexibilityNo cancel feeOn-time71%

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