$101+ Cheap flights from Irvine, CA to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/23. Fares are subject to change and may not be available on all flights or dates of travel.
LAX — TYS
Jun 4 — Jun 111
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Irvine to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Irvine to Knoxville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Irvine to KnoxvilleExplore the most affordable flight options available from Irvine to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
Explore the most affordable flight options available from Irvine to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
This Orbitz deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:30 am
LAX
- TYS
1 stop10h 06m
Frontier
Wed 8/58:32 pm
TYS
- LAX
1 stop14h 58m
Frontier
Deal found 5/4![Frontier logo]()
$210
This Travelocity deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:30 am
LAX
- TYS
1 stop10h 06m
Frontier
Mon 8/108:32 pm
TYS
- LAX
1 stop15h 23m
Frontier
Deal found 5/2![Frontier logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/199:43 am
LAX
- TYS
1 stop6h 54m
Multiple Airlines
Mon 8/242:51 pm
TYS
- LAX
1 stop30h 36m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$228
This Frontier deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:30 am
LAX
- TYS
1 stop10h 06m
Frontier
Mon 7/138:32 pm
TYS
- LAX
1 stop6h 39m
Frontier
Deal found 5/4![Frontier logo]()
$230
This Frontier deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:30 am
LAX
- TYS
1 stop10h 06m
Frontier
Mon 7/278:32 pm
TYS
- LAX
1 stop6h 39m
Frontier
Deal found 5/4![Frontier logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:59 pm
LAX
- TYS
1 stop14h 00m
Multiple Airlines
Fri 5/298:19 pm
TYS
- LAX
1 stop15h 16m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:59 pm
LAX
- TYS
1 stop14h 00m
Multiple Airlines
Sun 5/317:00 am
TYS
- LAX
2 stops53h 03m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/91:53 pm
LAX
- TYS
1 stop6h 34m
Multiple Airlines
Wed 8/128:32 pm
TYS
- LAX
1 stop14h 58m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:15 pm
LAX
- TYS
1 stop22h 31m
Multiple Airlines
Mon 8/246:27 pm
TYS
- LAX
1 stop27h 00m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$282
Best flights from Irvine to KnoxvilleDiscover carefully curated flight deals from Irvine to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
Discover carefully curated flight deals from Irvine to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/511:30 pm
LAX
- TYS
1 stop7h 13m
United Airlines
Tue 8/115:57 pm
TYS
- LAX
1 stop7h 28m
United Airlines
Deal found 5/2![United Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:15 am
LAX
- TYS
1 stop7h 12m
Delta
Sat 6/136:45 am
TYS
- LAX
1 stop7h 25m
Delta
Deal found 5/3![Delta logo]()
$352
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:30 am
LAX
- TYS
1 stop9h 20m
Southwest
Wed 10/77:00 am
TYS
- LAX
2 stops9h 45m
Southwest
Deal found 5/2![Southwest logo]()
$394
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:55 am
LAX
- TYS
1 stop7h 25m
Southwest
Wed 7/812:45 pm
TYS
- LAX
2 stops9h 25m
Southwest
Deal found 5/4![Southwest logo]()
$423
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:50 pm
LAX
- TYS
1 stop8h 21m
Delta
Mon 9/147:20 pm
TYS
- LAX
1 stop6h 55m
Delta
Deal found 5/4![Delta logo]()
$457
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:00 am
LAX
- TYS
1 stop7h 20m
Southwest
Sat 10/171:30 pm
TYS
- LAX
1 stop8h 15m
Southwest
Deal found 5/3![Southwest logo]()
$448
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:50 pm
LAX
- TYS
1 stop8h 21m
Delta
Sun 10/46:45 am
TYS
- LAX
1 stop9h 18m
Delta
Deal found 5/3![Delta logo]()
$487
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:45 am
LAX
- TYS
2 stops10h 35m
Southwest
Thu 7/164:20 pm
TYS
- LAX
2 stops8h 50m
Southwest
Deal found 5/4![Southwest logo]()
$449
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:40 am
LAX
- TYS
2 stops9h 55m
Southwest
Sun 8/235:55 pm
TYS
- LAX
2 stops8h 20m
Southwest
Deal found 5/5![Southwest logo]()
$467
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:15 am
LAX
- TYS
1 stop7h 12m
Delta
Wed 5/208:35 am
TYS
- LAX
1 stop7h 44m
Delta
Deal found 4/30![Delta logo]()
$517
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:40 am
LAX
- TYS
2 stops9h 55m
Southwest
Mon 9/148:25 am
TYS
- LAX
1 stop11h 35m
Southwest
Deal found 5/1![Southwest logo]()
$468
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/38:40 am
LAX
- TYS
2 stops9h 10m
Southwest
Wed 6/105:40 pm
TYS
- LAX
2 stops8h 20m
Southwest
Deal found 5/3![Southwest logo]()
$477
Last-minute flights from Irvine to KnoxvilleDiscover last-minute flight deals from Irvine to Knoxville. Data last updated May 5, 2026 and is based on user searches.
Discover last-minute flight deals from Irvine to Knoxville. Data last updated May 5, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:59 pm
LAX
- TYS
1 stop14h 00m
Multiple Airlines
Fri 5/298:19 pm
TYS
- LAX
1 stop15h 16m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:59 pm
LAX
- TYS
1 stop14h 00m
Multiple Airlines
Sun 5/317:00 am
TYS
- LAX
2 stops53h 03m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:31 pm
LAX
- TYS
2 stops26h 26m
Multiple Airlines
Fri 6/58:32 pm
TYS
- LAX
1 stop30h 44m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/34:31 pm
LAX
- TYS
1 stop18h 21m
Multiple Airlines
Wed 6/108:32 pm
TYS
- LAX
1 stop15h 01m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$318
This Frontier deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:30 am
LAX
- TYS
1 stop10h 03m
Frontier
Wed 6/178:32 pm
TYS
- LAX
1 stop20h 32m
Frontier
Deal found 5/5![Frontier logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/162:00 pm
LAX
- TYS
2 stops26h 37m
Multiple Airlines
Mon 6/225:43 pm
TYS
- LAX
1 stop17h 03m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2012:14 pm
LAX
- TYS
2 stops29h 34m
Multiple Airlines
Wed 6/248:32 pm
TYS
- LAX
1 stop20h 32m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:30 am
LAX
- TYS
1 stop10h 07m
Multiple Airlines
Sun 6/287:00 am
TYS
- LAX
2 stops35h 07m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$323
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2510:12 pm
LAX
- TYS
2 stops15h 28m
Multiple Airlines
Thu 7/27:00 am
TYS
- LAX
1 stop28h 33m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3012:14 pm
LAX
- TYS
2 stops25h 14m
Multiple Airlines
Sat 7/46:00 am
TYS
- LAX
1 stop15h 02m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$315
One-way flights from Irvine to KnoxvilleSearch for one-way flight options from Irvine to Knoxville. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
Search for one-way flight options from Irvine to Knoxville. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:59 pm
LAX
- TYS
1 stop14h 00m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$101
This Priceline deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:30 am
LAX
- TYS
1 stop10h 07m
Frontier
Deal found 5/5![Frontier logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/2310:10 am
LAX
- TYS
2 stops30h 27m
Frontier
Deal found 5/2![Frontier logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/2511:21 pm
LAX
- TYS
1 stop13h 49m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$126
This Frontier deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:30 am
LAX
- TYS
1 stop10h 03m
Frontier
Deal found 5/1![Frontier logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/39:40 am
LAX
- TYS
1 stop25h 12m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$144
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/222:00 pm
LAX
- TYS
2 stops50h 37m
Frontier
Deal found 5/2![Frontier logo]()
$146
This Frontier deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:30 am
LAX
- TYS
1 stop9h 54m
Frontier
Deal found 5/1![Frontier logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/912:14 pm
LAX
- TYS
2 stops28h 23m
Frontier
Deal found 5/4![Frontier logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/48:27 pm
LAX
- TYS
2 stops17h 13m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$158
Find flight deals from Irvine to Knoxville
Keep the following information in mind while searching for Irvine to Knoxville flight deals. Data was last updated May 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $210 (Orbitz) |
One-way from | $101 (Kiwi.com) |
Popular in | June |
Cheapest in | February |
Average price | $475 |
Cheapflights Fare Finder
Customize your flight search to find flights from Irvine to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from Irvine to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Wed 8/5
11:30 pm-9:43 am
1 stop7h 13m
Knoxville McGhee Tyson
Tue 8/11
5:57 pm-10:25 pm
1 stop7h 28m
$339
Quickest round-trip
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Mon 6/1
7:15 am-5:27 pm
1 stop7h 12m
Knoxville McGhee Tyson
Sat 6/13
6:45 am-11:10 am
1 stop7h 25m
$352
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Wed 9/30
7:30 am-7:50 pm
1 stop9h 20m
Knoxville McGhee Tyson
Wed 10/7
7:00 am-1:45 pm
2 stops9h 45m
$394
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Wed 7/1
7:55 am-6:20 pm
1 stop7h 25m
Knoxville McGhee Tyson
Wed 7/8
12:45 pm-7:10 pm
2 stops9h 25m
$423
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Thu 10/15
5:00 am-3:20 pm
1 stop7h 20m
Knoxville McGhee Tyson
Sat 10/17
1:30 pm-6:45 pm
1 stop8h 15m
$448
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Wed 7/8
6:45 am-8:20 pm
2 stops10h 35m
Knoxville McGhee Tyson
Thu 7/16
4:20 pm-10:10 pm
2 stops8h 50m
$449
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Fri 9/11
9:50 pm-9:11 am
1 stop8h 21m
Knoxville McGhee Tyson
Mon 9/14
7:20 pm-11:15 pm
1 stop6h 55m
$457
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Fri 8/21
5:40 am-6:35 pm
2 stops9h 55m
Knoxville McGhee Tyson
Sun 8/23
5:55 pm-11:15 pm
2 stops8h 20m
$467
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Fri 9/11
5:40 am-6:35 pm
2 stops9h 55m
Knoxville McGhee Tyson
Mon 9/14
8:25 am-5:00 pm
1 stop11h 35m
$468
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Wed 6/3
8:40 am-8:50 pm
2 stops9h 10m
Knoxville McGhee Tyson
Wed 6/10
5:40 pm-11:00 pm
2 stops8h 20m
$477
Showing 1-10 of 24 resultsSorted by cheapest first
Best time to book a flight from Irvine to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Irvine with our price prediction graph.
LAX-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Irvine to Knoxville
IR9-TYS
LAX-TYS
How much does it cost to fly round-trip from Irvine to Knoxville?
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated May 5, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Irvine to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.8
Overall
7.9
Food
7.2
Crew
8.5
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Boarding
8.1
Entertainment
7.8
Overall
7.9
Food
7.2
Crew
8.5
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Boarding
8.1
Entertainment
7.8
Overall
7.9
Food
7.2
Crew
8.5
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Boarding
8.1
Entertainment
7.8
Overall
7.9
Food
7.2
Crew
8.5
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Boarding
8.1
Entertainment
7.8
Overall
7.9
Food
7.2
Crew
8.5
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Related info for your journey
Find useful and relevant information for your journey from Irvine to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Knoxville flight routes
Other flight options
Popular flights
Top destinations
Alternative routes for Irvine to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Irvine to Knoxville by cabin class
Find flights from Irvine to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 5, 2026.
Irvine and Knoxville flights
Browse other Irvine and Knoxville flight options. Last updated on May 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Irvine to Knoxville flights
Consider these flights traveling from Irvine to Knoxville.
Top 5 airlines flying from Irvine to Knoxville
Discover the top 5 airlines that operate flights from Irvine to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$142 | Average$296 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$174 | Average$418 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$288 | Average$496 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$288 | Average$464 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$486 | Average$643 | FlexibilityNo cancel fee | On-time63% |