$133+ Cheap flights from Irvine, CA to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/15. Fares are subject to change and may not be available on all flights or dates of travel.
LAX — TYS
Jul 17 — Jul 241
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Irvine to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Irvine to Knoxville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Irvine to KnoxvilleExplore the most affordable flight options available from Irvine to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 17, 2026.
Explore the most affordable flight options available from Irvine to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 17, 2026.
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:30 am
LAX
- TYS
1 stop9h 25m
Delta
Wed 7/226:36 pm
TYS
- LAX
1 stop8h 17m
Delta
Deal found 6/14![Delta logo]()
$355
This Frontier deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:30 am
LAX
- TYS
1 stop9h 54m
Frontier
Fri 7/248:19 pm
TYS
- LAX
1 stop6h 52m
Frontier
Deal found 6/14![Frontier logo]()
$356
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am
LAX
- TYS
1 stop6h 30m
Delta
Sat 9/57:15 am
TYS
- LAX
1 stop10h 19m
Delta
Deal found 6/13![Delta logo]()
$357
This CheapOair deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/98:49 pm
LAX
- TYS
1 stop19h 35m
Frontier
Mon 7/138:19 pm
TYS
- LAX
1 stop15h 36m
Frontier
Deal found 6/12![Frontier logo]()
$358
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:05 am
LAX
- TYS
1 stop6h 00m
Southwest
Tue 7/2112:45 pm
TYS
- LAX
2 stops9h 25m
Southwest
Deal found 6/15![Southwest logo]()
$360
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:27 pm
LAX
- TYS
1 stop16h 46m
Multiple Airlines
Sun 9/137:00 am
TYS
- LAX
2 stops14h 50m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:45 pm
LAX
- TYS
2 stops19h 25m
Multiple Airlines
Mon 8/108:19 pm
TYS
- LAX
1 stop15h 36m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:15 pm
LAX
- TYS
1 stop22h 31m
Multiple Airlines
Mon 8/314:48 pm
TYS
- LAX
1 stop19h 37m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$371
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/11:56 pm
LAX
- TYS
1 stop30h 00m
Multiple Airlines
Sat 8/86:00 pm
TYS
- LAX
2 stops18h 30m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$372
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:35 pm
LAX
- TYS
2 stops26h 44m
Multiple Airlines
Mon 7/1310:05 pm
TYS
- LAX
1 stop22h 52m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$373
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:30 am
LAX
- TYS
1 stop9h 54m
Multiple Airlines
Fri 7/106:30 am
TYS
- LAX
2 stops14h 27m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$374
Best flights from Irvine to KnoxvilleDiscover carefully curated flight deals from Irvine to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 17, 2026.
Discover carefully curated flight deals from Irvine to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 17, 2026.
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:00 am
LAX
- TYS
1 stop6h 58m
United Airlines
Thu 9/177:20 pm
TYS
- LAX
1 stop8h 39m
United Airlines
Deal found 6/16![United Airlines logo]()
$376
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/275:00 am
LAX
- TYS
1 stop14h 35m
Southwest
Wed 7/2912:45 pm
TYS
- LAX
2 stops9h 25m
Southwest
Deal found 6/16![Southwest logo]()
$417
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1211:59 pm
LAX
- TYS
1 stop6h 37m
Delta
Wed 7/226:36 pm
TYS
- LAX
1 stop8h 17m
Delta
Deal found 6/14![Delta logo]()
$487
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/169:35 pm
LAX
- TYS
2 stops12h 50m
Southwest
Sat 8/296:50 am
TYS
- LAX
2 stops8h 20m
Southwest
Deal found 6/16![Southwest logo]()
$441
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/411:30 pm
LAX
- TYS
1 stop7h 13m
United Airlines
Tue 8/114:50 pm
TYS
- LAX
1 stop7h 02m
United Airlines
Deal found 6/15![United Airlines logo]()
$455
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/108:15 am
LAX
- TYS
2 stops10h 00m
Southwest
Tue 7/1412:45 pm
TYS
- LAX
1 stop9h 30m
Southwest
Deal found 6/12![Southwest logo]()
$451
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2812:09 am
LAX
- TYS
1 stop6h 48m
United Airlines
Tue 9/12:21 pm
TYS
- LAX
1 stop6h 46m
United Airlines
Deal found 6/12![United Airlines logo]()
$476
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:30 am
LAX
- TYS
1 stop6h 49m
Delta
Sat 7/186:40 am
TYS
- LAX
1 stop7h 30m
Delta
Deal found 6/13![Delta logo]()
$528
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:40 pm
LAX
- TYS
2 stops13h 45m
Southwest
Mon 8/312:05 pm
TYS
- LAX
2 stops9h 45m
Southwest
Deal found 6/13![Southwest logo]()
$453
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1110:35 am
LAX
- TYS
2 stops20h 22m
United Airlines
Wed 8/126:02 pm
TYS
- LAX
1 stop7h 23m
United Airlines
Deal found 6/16![United Airlines logo]()
$512
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2310:00 am
LAX
- TYS
1 stop6h 10m
Southwest
Tue 7/2812:45 pm
TYS
- LAX
2 stops9h 25m
Southwest
Deal found 6/14![Southwest logo]()
$501
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/206:35 am
LAX
- TYS
2 stops11h 40m
Southwest
Fri 7/246:40 am
TYS
- LAX
2 stops9h 05m
Southwest
Deal found 6/13![Southwest logo]()
$533
Last-minute flights from Irvine to KnoxvilleDiscover last-minute flight deals from Irvine to Knoxville. Data last updated June 17, 2026 and is based on user searches.
Discover last-minute flight deals from Irvine to Knoxville. Data last updated June 17, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/252:59 pm
LAX
- TYS
1 stop25h 38m
Frontier
Wed 7/18:32 pm
TYS
- LAX
1 stop20h 32m
Frontier
Deal found 6/17![Frontier logo]()
$400
This CheapOair deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/252:59 pm
LAX
- TYS
1 stop25h 38m
Frontier
Fri 7/248:19 pm
TYS
- LAX
1 stop6h 52m
Frontier
Deal found 6/16![Frontier logo]()
$406
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:30 am
LAX
- TYS
1 stop9h 54m
Multiple Airlines
Fri 7/106:30 am
TYS
- LAX
2 stops14h 27m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:30 am
LAX
- TYS
1 stop9h 54m
Multiple Airlines
Sun 7/127:00 am
TYS
- LAX
1 stop28h 30m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$382
This CheapOair deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/98:49 pm
LAX
- TYS
1 stop19h 35m
Frontier
Mon 7/138:19 pm
TYS
- LAX
1 stop15h 36m
Frontier
Deal found 6/12![Frontier logo]()
$358
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:35 pm
LAX
- TYS
2 stops26h 44m
Multiple Airlines
Mon 7/1310:05 pm
TYS
- LAX
1 stop22h 52m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$373
This Frontier deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:30 am
LAX
- TYS
1 stop9h 54m
Frontier
Fri 7/248:19 pm
TYS
- LAX
1 stop6h 52m
Frontier
Deal found 6/14![Frontier logo]()
$356
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:30 am
LAX
- TYS
1 stop9h 25m
Delta
Wed 7/226:36 pm
TYS
- LAX
1 stop8h 17m
Delta
Deal found 6/14![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:05 am
LAX
- TYS
1 stop6h 00m
Southwest
Tue 7/2112:45 pm
TYS
- LAX
2 stops9h 25m
Southwest
Deal found 6/15![Southwest logo]()
$360
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:30 am
LAX
- TYS
1 stop9h 54m
Multiple Airlines
Mon 7/2012:53 pm
TYS
- LAX
2 stops34h 10m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$397
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:35 pm
LAX
- TYS
2 stops26h 44m
Multiple Airlines
Mon 8/310:05 pm
TYS
- LAX
1 stop22h 52m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$390
One-way flights from Irvine to KnoxvilleSearch for one-way flight options from Irvine to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 17, 2026.
Search for one-way flight options from Irvine to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 17, 2026.
This Frontier deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:30 am
LAX
- TYS
1 stop9h 54m
Frontier
Deal found 6/15![Frontier logo]()
$133
This Frontier deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:30 am
LAX
- TYS
1 stop9h 54m
Frontier
Deal found 6/16![Frontier logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/11:56 pm
LAX
- TYS
1 stop30h 00m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$157
This CheapOair deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/99:05 pm
LAX
- TYS
1 stop19h 19m
Frontier
Deal found 6/16![Frontier logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/99:05 pm
LAX
- TYS
2 stops23h 07m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$168
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1511:34 pm
LAX
- TYS
2 stops38h 08m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$174
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:00 am
LAX
- TYS
1 stop8h 34m
American Airlines
Deal found 6/17![American Airlines logo]()
$178
This Frontier deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/66:30 am
LAX
- TYS
1 stop9h 54m
Frontier
Deal found 6/13![Frontier logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:35 pm
LAX
- TYS
2 stops26h 44m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$184
This CheapOair deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:35 pm
LAX
- TYS
1 stop22h 49m
Frontier
Deal found 6/16![Frontier logo]()
$185
Find flight deals from Irvine to Knoxville
Keep the following information in mind while searching for Irvine to Knoxville flight deals. Data was last updated June 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $355 (Delta) |
One-way from | $133 (Frontier) |
Popular in | June |
Cheapest in | February |
Average price | $545 |
Cheapflights Fare Finder
Customize your flight search to find flights from Irvine to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 17, 2026.
Use the filters below to find and compare flights from Irvine to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Tue 9/15
7:00 am-4:58 pm
1 stop6h 58m
Knoxville McGhee Tyson
Thu 9/17
7:20 pm-12:59 am
1 stop8h 39m
$376
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Mon 7/27
5:00 am-10:35 pm
1 stop14h 35m
Knoxville McGhee Tyson
Wed 7/29
12:45 pm-7:10 pm
2 stops9h 25m
$417
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Sun 8/16
9:35 pm-1:25 pm
2 stops12h 50m
Knoxville McGhee Tyson
Sat 8/29
6:50 am-12:10 pm
2 stops8h 20m
$441
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Fri 7/10
8:15 am-9:15 pm
2 stops10h 00m
Knoxville McGhee Tyson
Tue 7/14
12:45 pm-7:15 pm
1 stop9h 30m
$451
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Thu 8/27
8:40 pm-1:25 pm
2 stops13h 45m
Knoxville McGhee Tyson
Mon 8/31
2:05 pm-8:50 pm
2 stops9h 45m
$453
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Tue 8/4
11:30 pm-9:43 am
1 stop7h 13m
Knoxville McGhee Tyson
Tue 8/11
4:50 pm-8:52 pm
1 stop7h 02m
$455
Quickest round-trip
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Fri 8/28
12:09 am-9:57 am
1 stop6h 48m
Knoxville McGhee Tyson
Tue 9/1
2:21 pm-6:07 pm
1 stop6h 46m
$476
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Sun 7/12
11:59 pm-9:36 am
1 stop6h 37m
Knoxville McGhee Tyson
Wed 7/22
6:36 pm-11:53 pm
1 stop8h 17m
$487
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Thu 7/23
10:00 am-7:10 pm
1 stop6h 10m
Knoxville McGhee Tyson
Tue 7/28
12:45 pm-7:10 pm
2 stops9h 25m
$501
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Tue 8/11
10:35 am-9:57 am
2 stops20h 22m
Knoxville McGhee Tyson
Wed 8/12
6:02 pm-10:25 pm
1 stop7h 23m
$512
Showing 1-10 of 23 resultsSorted by cheapest first
Best time to book a flight from Irvine to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Irvine with our price prediction graph.
LAX-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Irvine to Knoxville
IR9-TYS
LAX-TYS
How much does it cost to fly round-trip from Irvine to Knoxville?
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 17, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Irvine to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Irvine to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Knoxville flight routes
Other flight options
Popular flights
Top destinations
Alternative routes for Irvine to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Irvine to Knoxville by cabin class
Find flights from Irvine to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 17, 2026.
Irvine and Knoxville flights
Browse other Irvine and Knoxville flight options. Last updated on June 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Irvine to Knoxville flights
Consider these flights traveling from Irvine to Knoxville.
Top 5 airlines flying from Irvine to Knoxville
Discover the top 5 airlines that operate flights from Irvine to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$144 | Average$297 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$245 | Average$544 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$288 | Average$510 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$288 | Average$473 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$288 | Average$436 | FlexibilityNo cancel fee | On-timeN/A |