$69+ Cheap flights from Irvine, CA to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from Irvine to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Irvine to Knoxville McGhee Tyson are usually found in August or July, booked 73 days in advance, depart on a Saturday or Tuesday and return on a Wednesday
Cheap flight deals from Irvine to Knoxville
Keep the following information in mind while searching for Irvine to Knoxville flight deals. Data was last updated November 6, 2025.
Most accurate provider | Mytrip 3 stars |
|---|---|
Most trusted provider | Mytrip 3 stars |
Round-trip from | $134 (Priceline) |
One-way from | $69 (Priceline) |
Popular in | January |
Cheapest in | August |
Average price | $479 |
Find flight deals from Irvine to Knoxville
Cheapest flights from Irvine to KnoxvilleExplore the most affordable flight options available from Irvine to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.
Explore the most affordable flight options available from Irvine to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.
This Priceline deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Booking.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Trip.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Frontier deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cheapflights Fare Finder
Use the filters below to find and compare flights from Irvine to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Mon 12/29
9:20 pm-3:51 pm
2 stops15h 31m
Knoxville McGhee Tyson
Mon 1/5
8:00 am-8:31 pm
1 stop15h 31m
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Tue 1/13
8:25 am-6:52 pm
1 stop7h 27m
Knoxville McGhee Tyson
Sun 1/18
7:30 am-2:46 pm
1 stop10h 16m
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Sat 1/10
10:48 am-9:02 pm
1 stop7h 14m
Knoxville McGhee Tyson
Sat 1/17
9:30 am-3:29 pm
1 stop8h 59m
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Sat 1/10
11:25 pm-10:57 am
1 stop8h 32m
Knoxville McGhee Tyson
Tue 1/20
11:10 am-3:31 pm
1 stop7h 21m
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Tue 12/2
12:25 am-10:13 am
1 stop6h 48m
Knoxville McGhee Tyson
Tue 12/9
7:05 am-11:23 am
1 stop7h 18m
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Tue 1/13
12:38 am-11:31 am
1 stop7h 53m
Knoxville McGhee Tyson
Sun 1/18
2:57 pm-8:34 pm
1 stop8h 37m
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Tue 2/3
7:55 pm-9:44 pm
2 stops22h 49m
Knoxville McGhee Tyson
Tue 2/10
2:17 pm-9:02 am
2 stops21h 45m
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Wed 11/12
8:25 am-8:06 pm
1 stop8h 41m
Knoxville McGhee Tyson
Sat 11/22
12:49 pm-8:37 pm
1 stop10h 48m
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Tue 12/9
12:25 am-10:13 am
1 stop6h 48m
Knoxville McGhee Tyson
Thu 12/11
7:00 am-11:52 am
1 stop7h 52m
Los AngelesKnoxville
LAX - TYS
LAXTYS
Los Angeles
Thu 12/4
12:25 am-10:13 am
1 stop6h 48m
Knoxville McGhee Tyson
Sun 12/7
7:25 pm-12:59 am
1 stop8h 34m
Best time to book a flight from Irvine to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Irvine with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from Irvine to Knoxville
How far ahead should I book a flight from Irvine to Knoxville?
Use this chart to determine the optimal time to book a round-trip flight from Irvine to Knoxville. Price data was last updated on October 31, 2025.
To ensure you get the cheapest price possible for a flight from Irvine to Knoxville, you should look to book at least 73 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Irvine to Knoxville?
Currently, January is the cheapest month in which you can book a flight from Irvine to Knoxville (average of $42). Flying from Irvine to Knoxville in June is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from IR9 to TYS?
Find hourly flight availability from Irvine to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.
One of the essential ways to save on airfare from Irvine to Knoxville is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 5% on airfare.
What is the cheapest day to fly from Irvine to Knoxville?
Use this chart to determine the cheapest time to fly round-trip from Irvine to Knoxville. Price data was last updated on December 16, 2024.
Travelers seeking maximum savings on their Irvine to Knoxville flight should consider departing on Saturday afternoons when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated November 6, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Irvine to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
Crew
Entertainment
Food
Comfort
Overall
Reviews
Michael,Sep 2023
SMF - ATL
Boarding
Crew
Entertainment
Food
Comfort
Overall
Reviews
Michael,Sep 2023
SMF - ATL
Boarding
Crew
Entertainment
Food
Comfort
Overall
Reviews
Michael,Sep 2023
SMF - ATL
Boarding
Crew
Entertainment
Food
Comfort
Overall
Reviews
Michael,Sep 2023
SMF - ATL
Boarding
Crew
Entertainment
Food
Comfort
Overall
Reviews
Michael,Sep 2023
SMF - ATL
Related info for your journey
Find useful and relevant information for your journey from Irvine to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Irvine to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from Irvine to Knoxville
Discover the top 4 airlines that operate flights from Irvine to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$158 | Average$360 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$239 | Average$526 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$269 | Average$453 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$276 | Average$417 | FlexibilityNo cancel fee | On-timeN/A |