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Knoxville

$117+ Cheap flights from Irvine, CA to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
LAX — TYS
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheapflights Tip: The best prices from Irvine to Knoxville McGhee Tyson are usually found in August or July, booked 73 days in advance, depart on a Saturday or Tuesday and return on a Wednesday

Cheap flight deals from Irvine to Knoxville

Keep the following information in mind while searching for Irvine to Knoxville flight deals. Data was last updated September 15, 2025.

Round-trip from

$289
(Kiwi.com)

One-way from

$117
(Kiwi.com)

Popular in

March

Cheapest in

August

Average price

$481
From Irvine to Knoxville McGhee Tyson
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One-way flight from Irvine to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 15% potential increase in price ($100 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Irvine to Knoxville

Cheapest flights from Irvine to Knoxville
Explore the most affordable flight options available from Irvine to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/209:20 amLAX - TYS
2 stops22h 13mMultiple Airlines
Fri 10/246:00 amTYS - LAX
1 stop9h 22mMultiple Airlines
Deal found 9/14$289
This Priceline deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/66:35 amLAX - TYS
1 stop10h 10mFrontier
Thu 10/98:17 pmTYS - LAX
1 stop7h 08mFrontier
Deal found 9/13$290
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/612:42 pmLAX - TYS
1 stop7h 16mMultiple Airlines
Mon 11/106:11 pmTYS - LAX
2 stops32h 04mMultiple Airlines
Deal found 9/13$291
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1311:15 amLAX - TYS
1 stop20h 18mMultiple Airlines
Fri 10/178:17 pmTYS - LAX
1 stop19h 02mMultiple Airlines
Deal found 9/14$292
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/52:13 pmLAX - TYS
1 stop20h 31mMultiple Airlines
Sat 11/810:54 amTYS - LAX
2 stops15h 21mMultiple Airlines
Deal found 9/13$294
This Frontier deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/286:35 amLAX - TYS
1 stop6h 43mFrontier
Mon 10/68:35 pmTYS - LAX
2 stops18h 48mFrontier
Deal found 9/14$296
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/51:18 pmLAX - TYS
1 stop6h 37mDelta
Sat 11/86:15 amTYS - LAX
1 stop6h 39mDelta
Deal found 9/14$299
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/269:36 amLAX - TYS
1 stop9h 54mMultiple Airlines
Sun 9/284:50 pmTYS - LAX
1 stop23h 43mMultiple Airlines
Deal found 9/15$300
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2310:11 pmLAX - TYS
1 stop13h 08mMultiple Airlines
Mon 10/2711:00 amTYS - LAX
2 stops25h 40mMultiple Airlines
Deal found 9/14$302
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/272:31 pmLAX - TYS
1 stop20h 12mMultiple Airlines
Mon 10/610:46 amTYS - LAX
2 stops37h 39mMultiple Airlines
Deal found 9/14$304
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/712:40 pmLAX - TYS
1 stop18h 24mMultiple Airlines
Sun 11/97:00 amTYS - LAX
1 stop20h 25mMultiple Airlines
Deal found 9/13$305

Cheapflights Fare Finder

 
Customize your flight search to find flights from Irvine to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Irvine to Knoxville that are best for you.

Fly from

Irvine

Fly to

Knoxville

Route

Depart

Return

Price

Los AngelesKnoxville

LAX - TYS

LAXTYS

Los Angeles

Wed 11/5

2:13 pm-1:44 pm

1 stop20h 31m

Knoxville McGhee Tyson

Sat 11/8

10:54 am-11:15 pm

2 stops15h 21m

$294

Los AngelesKnoxville

LAX - TYS

LAXTYS

Los Angeles

Tue 10/14

9:45 pm-9:00 am

1 stop8h 15m

Knoxville McGhee Tyson

Wed 10/22

5:16 pm-9:49 pm

1 stop7h 33m

$299

Los AngelesKnoxville

LAX - TYS

LAXTYS

Los Angeles

Wed 11/5

11:19 am-11:22 pm

1 stop9h 03m

Knoxville McGhee Tyson

Sat 11/8

6:15 am-9:54 am

1 stop6h 39m

$299

Los AngelesKnoxville

LAX - TYS

LAXTYS

Los Angeles

Sun 10/5

12:09 am-4:41 pm

2 stops13h 32m

Knoxville McGhee Tyson

Thu 10/9

9:50 pm-8:28 am

1 stop13h 38m

$300

Los AngelesKnoxville

LAX - TYS

LAXTYS

Los Angeles

Wed 10/22

1:15 pm-7:32 pm

1 stop27h 17m

Knoxville McGhee Tyson

Sun 10/26

5:34 pm-7:35 am

2 stops17h 01m

$302

Los AngelesKnoxville

LAX - TYS

LAXTYS

Los Angeles

Sat 9/27

2:31 pm-1:43 pm

1 stop20h 12m

Knoxville McGhee Tyson

Mon 10/6

10:46 am-9:25 pm

2 stops37h 39m

$304

Los AngelesKnoxville

LAX - TYS

LAXTYS

Los Angeles

Fri 10/17

2:04 pm-11:51 pm

1 stop6h 47m

Knoxville McGhee Tyson

Tue 10/21

10:22 am-4:42 pm

1 stop9h 20m

$320

Los AngelesKnoxville

LAX - TYS

LAXTYS

Los Angeles

Fri 10/3

11:10 am-10:18 am

1 stop20h 08m

Knoxville McGhee Tyson

Tue 10/7

11:23 am-1:20 pm

2 stops28h 57m

$334

Los AngelesKnoxville

LAX - TYS

LAXTYS

Los Angeles

Thu 11/6

6:44 am-6:22 pm

1 stop8h 38m

Knoxville McGhee Tyson

Sun 11/9

7:17 pm-12:25 am

1 stop8h 08m

$344

Los AngelesKnoxville

LAX - TYS

LAXTYS

Los Angeles

Wed 10/22

1:15 pm-7:32 pm

1 stop27h 17m

Knoxville McGhee Tyson

Sun 10/26

8:17 pm-7:35 am

1 stop14h 18m

$356

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Showing 1-10 of 20 results
1
2

Best time to book a flight from Irvine to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Irvine with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Irvine to Knoxville

How far ahead should I book a flight from Irvine to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Irvine to Knoxville. Price data was last updated on September 12, 2025.

To ensure you get the cheapest price possible for a flight from Irvine to Knoxville, you should look to book at least 73 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Irvine to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Irvine to Knoxville (average of $294). Flying from Irvine to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IR9 to TYS?

Find hourly flight availability from Irvine to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Irvine to Knoxville as you normally would.

What is the cheapest day to fly from Irvine to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Irvine to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Irvine to Knoxville flight should consider departing on Thursday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 15, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Irvine to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,956 reviews

Overall

8.0

Crew

8.5

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Delta
8.0
Very good
7,956 reviews
Delta
8.0
Very good
7,956 reviews

Overall

8.0

Crew

8.5

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
United Airlines
7.4
Good
8,931 reviews
Delta
8.0
Very good
7,956 reviews

Overall

8.0

Crew

8.5

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,956 reviews

Overall

8.0

Crew

8.5

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Frontier
5.8
Fair
3,173 reviews
Delta
8.0
Very good
7,956 reviews

Overall

8.0

Crew

8.5

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from Irvine to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Irvine?

    For a flight from Irvine to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city. McGhee Tyson is the only Knoxville airport and it handles 0 inbound flights from Irvine per day. 4 airlines have flights to Knoxville McGhee Tyson from Irvine on a regular basis.

  • How long is the flight from Irvine to Knoxville?

    Delta can get you from Irvine to Knoxville in just under 8h 15m. Your travel time can differ by up to . Airlines will cover a distance of 1944 mi.

  • Can I find deals for flights from Irvine to Knoxville that include hotel bookings?

    Yes. In addition to deals on Irvine to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Irvine to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Irvine to Knoxville.

  • Can I find deals for business class flights from Irvine to Knoxville?

    Yes. Cheapflights offers flight deals from Irvine to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Irvine to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Irvine to Knoxville (average of $294). Flying from Irvine to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 4 airlines flying from Irvine to Knoxville

Discover the top 4 airlines that operate flights from Irvine to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$155Average$329FlexibilityNo cancel feeOn-time62%
DeltaCheapest$192Average$402FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$239Average$516FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$277Average$445FlexibilityNo cancel feeOn-time71%

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