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$215+ Cheap flights from Fort Myers to Knoxville (RSW - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — TYS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Fort Myers SW Florida Intl to Knoxville McGhee Tyson are usually found in September or March, booked 51 days in advance, depart on a Wednesday or Saturday and return on a Wednesday

Cheap flight deals from Fort Myers to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Fort Myers (RSW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$177
(Delta)

Popular in

June

Cheapest in

September

Average price

$248
From Fort Myers SW Florida Intl to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 14% potential increase in price ($55 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Fort Myers to Knoxville

Cheapest flights from Fort Myers to Knoxville
Explore the most affordable flight options available from Fort Myers to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/177:32 pmRSW - TYS
1 stop4h 21mAmerican Airlines
Wed 10/225:00 amTYS - RSW
1 stop5h 18mAmerican Airlines
Deal found 9/9$224
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/225:38 amRSW - TYS
1 stop3h 22mDelta
Mon 10/278:10 pmTYS - RSW
1 stop4h 29mDelta
Deal found 9/10$225
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/225:20 pmRSW - TYS
1 stop5h 34mAmerican Airlines
Wed 11/265:51 pmTYS - RSW
1 stop6h 57mAmerican Airlines
Deal found 9/11$237
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/244:35 pmRSW - TYS
1 stop6h 15mUnited Airlines
Fri 10/318:26 amTYS - RSW
1 stop6h 15mUnited Airlines
Deal found 9/10$266
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/274:11 pmRSW - TYS
1 stop3h 59mDelta
Thu 10/307:11 amTYS - RSW
1 stop4h 39mDelta
Deal found 9/11$273
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/226:39 pmRSW - TYS
1 stop4h 28mAmerican Airlines
Sat 10/255:00 amTYS - RSW
1 stop4h 07mAmerican Airlines
Deal found 9/10$287
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/246:39 pmRSW - TYS
1 stop4h 28mAmerican Airlines
Mon 10/276:11 pmTYS - RSW
1 stop5h 22mAmerican Airlines
Deal found 9/8$299
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/95:38 amRSW - TYS
1 stop3h 22mDelta
Tue 10/145:44 amTYS - RSW
1 stop4h 24mDelta
Deal found 9/10$316
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/259:10 amRSW - TYS
1 stop7h 58mUnited Airlines
Sat 11/296:45 amTYS - RSW
1 stop6h 47mUnited Airlines
Deal found 9/10$329
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/242:26 pmRSW - TYS
1 stop6h 14mUnited Airlines
Sat 10/259:55 amTYS - RSW
1 stop6h 02mUnited Airlines
Deal found 9/10$336

Cheapflights Fare Finder

 
Customize your flight search to find flights from Fort Myers to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Fort Myers to Knoxville that are best for you.

Fly from

Fort Myers

Fly to

Knoxville

Route

Depart

Return

Price

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Wed 10/22

6:58 am-10:45 am

1 stop3h 47m

Knoxville McGhee Tyson

Sun 10/26

8:10 pm-12:39 am

1 stop4h 29m

$225

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 11/7

9:10 am-5:08 pm

1 stop7h 58m

Knoxville McGhee Tyson

Sun 11/9

8:26 am-2:44 pm

1 stop6h 18m

$273

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 10/24

6:39 pm-11:07 pm

1 stop4h 28m

Knoxville McGhee Tyson

Mon 10/27

6:11 pm-11:33 pm

1 stop5h 22m

$273

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Mon 10/27

4:11 pm-8:10 pm

1 stop3h 59m

Knoxville McGhee Tyson

Thu 10/30

7:11 am-11:50 am

1 stop4h 39m

$273

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 10/17

5:38 am-9:20 am

1 stop3h 42m

Knoxville McGhee Tyson

Fri 10/24

8:10 pm-12:39 am

1 stop4h 29m

$273

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Mon 11/10

4:12 pm-8:06 pm

1 stop3h 54m

Knoxville McGhee Tyson

Mon 11/17

3:51 pm-9:34 pm

1 stop5h 43m

$299

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 11/7

5:38 am-9:20 am

1 stop3h 42m

Knoxville McGhee Tyson

Sun 11/9

8:05 pm-12:37 am

1 stop4h 32m

$316

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Thu 10/9

5:38 am-9:00 am

1 stop3h 22m

Knoxville McGhee Tyson

Tue 10/14

5:44 am-10:08 am

1 stop4h 24m

$316

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 10/24

2:26 pm-8:40 pm

1 stop6h 14m

Knoxville McGhee Tyson

Sat 10/25

9:55 am-3:57 pm

1 stop6h 02m

$336

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 10/17

9:10 am-5:18 pm

1 stop8h 08m

Knoxville McGhee Tyson

Wed 10/22

8:50 am-11:14 pm

2 stops14h 24m

$341

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 12 results
1
2

Best time to book a flight from Fort Myers to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Fort Myers with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Knoxville

How far ahead should I book a flight from Fort Myers to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Fort Myers to Knoxville. Price data was last updated on August 29, 2025.

To ensure you get the cheapest price possible for a flight from Fort Myers to Knoxville, you should look to book at least 20 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Fort Myers to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Fort Myers to Knoxville (average of $294). Flying from Fort Myers to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from RSW to TYS?

Find hourly flight availability from Fort Myers to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from Fort Myers to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 40% versus a flight at noon.

What is the cheapest day to fly from Fort Myers to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Fort Myers to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Fort Myers to Knoxville flight should consider departing on Wednesday evenings when fares are most often at their lowest. Thursday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 11, 2025.
See what other customers who have flown with Delta and American Airlines from Fort Myers to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Fort Myers to Knoxville?

    There are many flights that can get you from Fort Myers to Knoxville in 3h 47m. Fly via Delta, United Airlines, or American Airlines to get the fastest option. Fort Myers and Knoxville are separated by a distance of 653 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Fort Myers to Knoxville round-trip?

    American Airlines, at $223, was found to be the cheapest airline from Fort Myers to Knoxville. An alternate airline flying to your destination would be Delta. American Airlines is priced at 33% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Fort Myers to Knoxville that include hotel bookings?

    Yes. In addition to deals on Fort Myers to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Fort Myers to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Knoxville.

  • Can I find deals for business class flights from Fort Myers to Knoxville?

    Yes. Cheapflights offers flight deals from Fort Myers to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Fort Myers to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Fort Myers to Knoxville (average of $294). Flying from Fort Myers to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Fort Myers to Knoxville

Discover the top 2 airlines that operate flights from Fort Myers to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$223Average$331FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$346FlexibilityNo cancel feeOn-timeN/A

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