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$150+ Cheap flights from Fort Myers to Knoxville (RSW - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — TYS
Nov 26 — Dec 31
Wed 11/26
Wed 12/3
1 adult, Economy
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Cheap flight deals from Fort Myers to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Fort Myers (RSW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 27, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$259
(Delta)

One-way from

$150
(Delta)

Popular in

October

Cheapest in

March

Average price

$456
Provider with most accurate pricing for Fort Myers SW Florida Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Fort Myers SW Florida Intl-Knoxville McGhee Tyson flights.
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From Fort Myers SW Florida Intl to Knoxville McGhee Tyson
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One-way flight from Fort Myers SW Florida Intl to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 6% potential increase in price ($23 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Fort Myers to Knoxville

Cheapest flights from Fort Myers to Knoxville
Explore the most affordable flight options available from Fort Myers to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.

This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/57:49 pmRSW - TYS
1 stop3h 39mDelta
Tue 12/92:37 pmTYS - RSW
1 stop4h 07mDelta
Deal found 10/25$279
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:38 pmRSW - TYS
1 stop5h 50mDelta
Mon 12/155:40 amTYS - RSW
1 stop4h 04mDelta
Deal found 10/26$319
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1910:27 amRSW - TYS
1 stop6h 17mAmerican Airlines
Mon 12/225:40 pmTYS - RSW
1 stop6h 48mAmerican Airlines
Deal found 10/27$344
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/85:20 pmRSW - TYS
1 stop6h 31mAmerican Airlines
Tue 11/1110:16 amTYS - RSW
1 stop7h 13mAmerican Airlines
Deal found 10/26$349
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/107:49 pmRSW - TYS
1 stop3h 52mDelta
Fri 11/148:07 pmTYS - RSW
1 stop4h 30mDelta
Deal found 10/26$397
This Mytrip deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:29 pmRSW - TYS
2 stops18h 26mMultiple Airlines
Mon 12/151:05 pmTYS - RSW
3 stops30h 18mMultiple Airlines
Deal found 10/26$399
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:40 pmRSW - TYS
1 stop4h 07mAmerican Airlines
Tue 12/305:40 pmTYS - RSW
1 stop6h 43mAmerican Airlines
Deal found 10/26$408
This Mytrip deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/123:23 pmRSW - TYS
3 stops31h 10mMultiple Airlines
Sat 11/1510:54 amTYS - RSW
3 stops22h 57mMultiple Airlines
Deal found 10/26$415
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:38 amRSW - TYS
1 stop3h 42mDelta
Tue 11/115:35 amTYS - RSW
1 stop4h 09mDelta
Deal found 10/26$416

Cheapflights Fare Finder

 
Customize your flight search to find flights from Fort Myers to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 27, 2025.
Use the filters below to find and compare flights from Fort Myers to Knoxville that are best for you.

Fly from

Fort Myers

Fly to

Knoxville

Route

Depart

Return

Price

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Wed 2/18

5:35 am-9:13 am

1 stop3h 38m

Knoxville McGhee Tyson

Sat 2/21

10:05 am-1:57 pm

1 stop3h 52m

$259

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 12/5

7:49 pm-11:28 pm

1 stop3h 39m

Knoxville McGhee Tyson

Tue 12/9

2:37 pm-6:44 pm

1 stop4h 07m

$279

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 12/19

10:27 am-4:44 pm

1 stop6h 17m

Knoxville McGhee Tyson

Mon 12/22

5:40 pm-12:28 am

1 stop6h 48m

$344

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Wed 11/12

6:55 am-10:45 am

1 stop3h 50m

Knoxville McGhee Tyson

Sat 11/15

8:45 am-3:03 pm

1 stop6h 18m

$349

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 3/6

7:49 pm-11:52 pm

1 stop4h 03m

Knoxville McGhee Tyson

Mon 3/9

12:40 pm-6:11 pm

1 stop5h 31m

$359

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 3/6

2:25 pm-9:15 pm

1 stop6h 50m

Knoxville McGhee Tyson

Mon 3/9

1:20 pm-11:20 pm

2 stops10h 00m

$372

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Mon 11/10

7:49 pm-11:41 pm

1 stop3h 52m

Knoxville McGhee Tyson

Fri 11/14

8:07 pm-12:37 am

1 stop4h 30m

$397

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 12/12

8:29 pm-2:55 pm

2 stops18h 26m

Knoxville McGhee Tyson

Mon 12/15

1:05 pm-7:23 pm

3 stops30h 18m

$399

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 2/21

4:24 pm-8:27 pm

1 stop4h 03m

$150

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 2/14

5:35 am-9:13 am

1 stop3h 38m

$150

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/26

Showing 1-10 of 20 results
1
2

Compare providers for flights from Fort Myers to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to Knoxville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Fort Myers-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Fort Myers-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Fort Myers-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Fort Myers-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Fort Myers to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Fort Myers with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Knoxville

What is the cheapest month to book a flight from Fort Myers to Knoxville?

Currently, February is the cheapest month in which you can book a flight from Fort Myers to Knoxville (average of $53). Flying from Fort Myers to Knoxville in October is currently the most expensive (average of $84). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from RSW to TYS?

Find hourly flight availability from Fort Myers to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 27, 2025.

When flying from Fort Myers to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 39% versus a flight at noon.

What is the cheapest day to fly from Fort Myers to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Fort Myers to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Fort Myers to Knoxville flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 27, 2025.
See what other customers who have flown with Delta and American Airlines from Fort Myers to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,996 reviews

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
7,996 reviews
Delta
7.9
Good
7,996 reviews

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,033 reviews
Delta
7.9
Good
7,996 reviews

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Fort Myers to Knoxville?

    There are many flights that can get you from Fort Myers to Knoxville in 3h 38m. Fly via Delta or American Airlines to get the fastest option. Fort Myers and Knoxville are separated by a distance of 653 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Fort Myers to Knoxville round-trip?

    American Airlines, at $228, was found to be the cheapest airline from Fort Myers to Knoxville. An alternate airline flying to your destination would be Delta. American Airlines is priced at 35% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Fort Myers to Knoxville that include hotel bookings?

    Yes. In addition to deals on Fort Myers to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Fort Myers to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Knoxville.

  • Can I find deals for business class flights from Fort Myers to Knoxville?

    Yes. Cheapflights offers flight deals from Fort Myers to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Fort Myers to Knoxville?

    Currently, February is the cheapest month in which you can book a flight from Fort Myers to Knoxville (average of $53). Flying from Fort Myers to Knoxville in October is currently the most expensive (average of $84). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Fort Myers to Knoxville

Discover the top 2 airlines that operate flights from Fort Myers to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$348FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$355FlexibilityNo cancel feeOn-timeN/A

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