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$125+ Cheap flights from Fort Myers to Knoxville (RSW - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — TYS
Apr 9 — Apr 161
Thu 4/9
Thu 4/16
1 adult, Economy
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Cheap flight deals from Fort Myers to Knoxville

Cheapest flights from Fort Myers to Knoxville
Explore the most affordable flight options available from Fort Myers to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:41 pm
RSW
-
TYS
1 stop4h 14m
American Airlines
Mon 4/275:00 am
TYS
-
RSW
1 stop6h 29m
American Airlines
Deal found 3/9$271
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/94:40 pm
RSW
-
TYS
1 stop3h 40m
Southwest
Tue 6/168:10 am
TYS
-
RSW
2 stops13h 00m
Southwest
Deal found 3/8$280
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/177:41 pm
RSW
-
TYS
1 stop4h 14m
American Airlines
Mon 4/203:58 pm
TYS
-
RSW
1 stop4h 57m
American Airlines
Deal found 3/6$285
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/289:02 pm
RSW
-
TYS
2 stops35h 06m
Multiple Airlines
Sun 4/57:30 am
TYS
-
RSW
1 stop10h 49m
Multiple Airlines
Deal found 3/5$295
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:39 pm
RSW
-
TYS
1 stop4h 10m
American Airlines
Thu 7/305:00 am
TYS
-
RSW
1 stop4h 06m
American Airlines
Deal found 3/7$299
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:35 am
RSW
-
TYS
1 stop3h 59m
Delta
Wed 5/271:57 pm
TYS
-
RSW
1 stop6h 47m
Delta
Deal found 3/5$301
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/174:40 pm
RSW
-
TYS
1 stop3h 40m
Southwest
Sun 6/217:00 pm
TYS
-
RSW
1 stop3h 55m
Southwest
Deal found 3/6$308
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/303:43 pm
RSW
-
TYS
2 stops22h 27m
Multiple Airlines
Sun 4/57:30 am
TYS
-
RSW
1 stop10h 49m
Multiple Airlines
Deal found 3/5$315
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:06 pm
RSW
-
TYS
1 stop6h 39m
Delta
Wed 10/215:30 am
TYS
-
RSW
1 stop4h 29m
Delta
Deal found 3/5$322

Find flight deals from Fort Myers to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Fort Myers (RSW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$271
(American Airlines)

One-way from

$125
(American Airlines)

Popular in

January

Cheapest in

September
Provider with most accurate pricing for Fort Myers SW Florida Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Fort Myers SW Florida Intl-Knoxville McGhee Tyson flights.
Search Deals
From Fort Myers SW Florida Intl to Knoxville McGhee Tyson
Search Deals
One-way flight from Fort Myers SW Florida Intl to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($93 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($30 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Fort Myers to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Fort Myers to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Thu 5/21

10:15 am-8:20 pm

2 stops10h 05m

Knoxville McGhee Tyson

Tue 5/26

12:50 pm-9:35 pm

1 stop8h 45m

$399

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sun 3/29

5:30 am-9:16 am

1 stop3h 46m

Knoxville McGhee Tyson

Mon 4/6

5:10 pm-11:24 pm

1 stop6h 14m

$402

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Thu 5/28

11:50 am-8:20 pm

2 stops8h 30m

Knoxville McGhee Tyson

Sun 5/31

7:45 am-6:25 pm

2 stops10h 40m

$407

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Tue 3/24

5:25 am-11:50 am

1 stop6h 25m

Knoxville McGhee Tyson

Sat 3/28

6:35 am-3:05 pm

1 stop8h 30m

$408
Quickest round-trip

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 3/20

7:57 pm-11:57 pm

1 stop4h 00m

Knoxville McGhee Tyson

Tue 3/24

5:10 pm-9:37 pm

1 stop4h 27m

$428

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Tue 3/24

5:25 am-11:50 am

1 stop6h 25m

Knoxville McGhee Tyson

Fri 3/27

6:30 am-4:30 pm

2 stops10h 00m

$438

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 5/16

10:30 am-6:30 pm

1 stop8h 00m

Knoxville McGhee Tyson

Sun 5/17

6:40 am-1:40 pm

2 stops7h 00m

$439

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Wed 4/8

2:40 pm-8:50 pm

1 stop6h 10m

Knoxville McGhee Tyson

Sun 4/12

12:15 pm-9:40 pm

1 stop9h 25m

$439

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 3/21

10:25 am-9:05 pm

2 stops10h 40m

Knoxville McGhee Tyson

Wed 3/25

7:50 am-5:30 pm

2 stops9h 40m

$453

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 4/4

9:35 am-6:35 pm

2 stops9h 00m

Knoxville McGhee Tyson

Sat 4/11

7:45 am-4:15 pm

2 stops8h 30m

$457

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/5

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Compare providers for flights from Fort Myers to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to Knoxville in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Fort Myers-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Fort Myers-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Fort Myers-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Fort Myers-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Fort Myers to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Fort Myers with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Knoxville

What is the cheapest month to book a flight from Fort Myers to Knoxville?

Currently, May is the cheapest month in which you can book a flight from Fort Myers to Knoxville (average of $57). Flying from Fort Myers to Knoxville in February is currently the most expensive (average of $86). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 10, 2026.
See what other customers who have flown with Delta and American Airlines from Fort Myers to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,276 reviews

Crew

8.5

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,276 reviews
Delta
7.9
Good
8,276 reviews

Crew

8.5

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.1
Good
11,414 reviews
Delta
7.9
Good
8,276 reviews

Crew

8.5

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Fort Myers to Knoxville?

    There are many flights that can get you from Fort Myers to Knoxville in 3h 46m. Fly via Southwest or Delta to get the fastest option. Fort Myers and Knoxville are separated by a distance of 653 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Fort Myers to Knoxville round-trip?

    American Airlines, at $248, was found to be the cheapest airline from Fort Myers to Knoxville. An alternate airline flying to your destination would be Delta. American Airlines is priced at 40% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Fort Myers to Knoxville that include hotel bookings?

    Yes. In addition to deals on Fort Myers to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Fort Myers to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Knoxville.

  • Can I find deals for business class flights from Fort Myers to Knoxville?

    Yes. Cheapflights offers flight deals from Fort Myers to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Fort Myers to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from Fort Myers to Knoxville (average of $57). Flying from Fort Myers to Knoxville in February is currently the most expensive (average of $86). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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Top 2 airlines flying from Fort Myers to Knoxville

Discover the top 2 airlines that operate flights from Fort Myers to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$404FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$373FlexibilityNo cancel feeOn-timeN/A

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